CN107929346A - Treat Chinese medicine composition of eczema and preparation method thereof - Google Patents
Treat Chinese medicine composition of eczema and preparation method thereof Download PDFInfo
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- CN107929346A CN107929346A CN201810016961.XA CN201810016961A CN107929346A CN 107929346 A CN107929346 A CN 107929346A CN 201810016961 A CN201810016961 A CN 201810016961A CN 107929346 A CN107929346 A CN 107929346A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
Chinese medicine composition the invention discloses treatment eczema and preparation method thereof, belongs to the Chinese medicine therapy field of eczema.The present invention discloses a kind of Chinese medicine composition for treating eczema first, including：Myrrh and honeysuckle.The present invention further discloses a kind of method for preparing the Chinese medicine composition, comprise the following steps：After each component is mixed immersion, add water to be decocted, filter, collect filtrate, to obtain the final product.Clinical efficacy the result shows that, the present invention prepared by myrrh with honeysuckle compatibility traditional Chinese medicine composition for treating eczema the effect of it is definite, treat obvious effective rate reach more than 90%.Prove, there is obvious synergistic function between myrrh and honeysuckle.The compatibility of Chinese medicine composition of the present invention is reasonable, has no toxic side effect, and preparation method is simple.
Description
Technical field
The present invention relates to the Chinese medicine composition for the treatment of eczema, the preparation method of the Chinese medicine composition is further related to, belongs to wet
The Chinese medicine therapy field of rash.
Background technology
Eczema is a kind of common epidermis as caused by a variety of internal and external factors and the inflammatory dermatoses of high dermis, generally
Think there is certain relation with allergy.Its clinical manifestation has symmetry, exudative, pruritus dermatopathy, pleomorphism and answers
The features such as hair property.Eczema is a kind of skin disease easily recurred, and treatment needs recurrent medicine dedicated, such as contains health cleaning skin component
Medicine, eczema is also a kind of allergic inflammation dermatoses, with fash diversity is symmetrical, violent itch recurrent exerbation,
Easily evolve into chronic be characterized.Any age, any position, any season can be betided, but often recurs or aggravates in the winter time, is had
Exudation tendency, the chronic course of disease, easy recurrent exerbation.
It is divided into acute eczema, subacute eczema, chronic eczema
Acute eczema
Feel violent itch, skin lesion pleomorphism, erythema, papule, papulo-vesicle or blister are intensive in flakes, and easily exudation, edge is not
Clearly, small papule, papulo-vesicle are around dispersed in, often companion is rotten to the corn, scabs, and such as scabies secondary infection, may occur in which useless fellow or dense scab.Processing is appropriate then
Inflammation mitigates, and skin lesion can disappear after 2~3 weeks, but often recurrent exerbation can simultaneously switch to subacute or chronic eczema.
Subacute eczema
After acute eczema inflammation mitigates, still there is violent itch, skin lesion is based on papule, incrustation and the scales of skin that peel off, it is seen that Shao Liangqiu
Bleb is slight rotten to the corn.Deal with improperly, then acute attack or chronic eczema can be switched to.
Chronic eczema
Often switch to chronic eczema because acute, subacute eczema recurrent exerbation is not cured；Also unobvious can be started, because often scratching
Grab, rub or other stimulations, so that as chronic eczema when morbidity starts.It shows as illing skin infiltration plumpness, and surface is thick
Rough, in kermesinus or with pigmentation, skin lesion is mostly limitation patch, is common in brothers, shank, the fossa cubitalis, breast, vulva, anus
Door etc., clear-cut margin.The course of disease is chronic, is several months or several years, also can the acute attack because of stimulation.Some patients from the beginning of
Fash has been chronic eczema.Acute eczema is mainly shown as the difficult water seen of erythema, distribution or red papules in groups, naked eyes
Blister, warts can be played by having during scabies secondary infection, sepage is more when serious, expose ruddy moist rotten to the corn face.
General treatment, 0.25% Procaine injection of intravenous administration add vitamin C；Also calcium gluconate can be used；It is local
The psoriasis of property can embrocate affected part with the medicine of itch-stopping bactericidal.
Oral antisensitizer is used for reduce inflammation reaction and pruritis, such as oral chlorpheniramine, Loratadine, chlorine thunder he
Fixed, Mizolastine etc..
Other drugs include hydroxychloroquine, indocin, aspirin, glycyrrhizin etc..External used medicine is mainly hormone replacement
Treatment uses, and common drug includes calcium tune nerve enzyme inhibitor such as Tacrolimus paste, nonsteroidal ointment etc..But treating
When, effect is bad, and recurrence rate is low, and puzzlement and pain are brought to patient.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of Chinese medicine composition for treating eczema, the Chinese medicine composition pair
The treatment total effective rate of eczema is high, curative for effect and without side-effects；
Another technical problem to be solved by this invention is to provide a kind of preparation method of the Chinese medicine composition.
In order to solve the above technical problems, the technical solution used in the present invention is：
The present invention discloses a kind of Chinese medicine composition for treating eczema, including following each component first：Myrrh and honeysuckle.
The parts by weight of each component are：20-50 parts of myrrh, 20-50 parts of honeysuckle.As the preferred technical solution of the present invention, each component
Parts by weight are：30 parts of myrrh, 30 parts of honeysuckle.
Myrrh is olive subject plant Chinese violet tree Commiphora myrrha Engl. or breathes out Chinese violet tree Commiphora
The dry resin of molmol Engl..It is divided into natural myrrh and gum opoponax.It is distributed in Somalia, Ethiopia and Arab
The ground such as peninsula south.With scattered stasis pain, the effect of detumescence and promoting granulation.It is usually used in chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea Amenorrhea, production
The treatment of the illnesss such as stasis blocking , Disorder lump in the abdomen is suffered from abdominal pain afterwards, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore.
Honeysuckle, also known as honeysuckle (scientific name：Lonicera japonica)." honeysuckle " one is come from《Compendium of Materia Medica》, by
Just opened in honeysuckle flowers as white, after switch to yellow, hence obtain one's name honeysuckle.Medicinal material honeysuckle is Caprifoliaceae woodbine honeysuckle
And congener dry flower or its effect is mainly clearing heat and detoxicating with the flower just opened, cure mainly warm disease heating, toxic-heat and blood stasis, ulcer
Serious case of furuncle etc..Modern study proves that honeysuckle contains the pharmacological components such as chlorogenic acid, cyanidenon glycosides, to hemolytic streptococcus,
The various pathogens such as Staphylococcus aureus and infection of the upper respiratory tract Causative virus etc. have stronger restraint, in addition can also strengthen and exempt from
Epidemic disease power, Robust speaker feature, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), suppression intestinal absorption cholesterol etc., its clinical application
Widely, can be used to treat respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. 40 with other medicines compatibility
Remaining kind of illness.
Honeysuckle is cold in nature, sweet in flavor, enters lung, the heart, stomach, has effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind, cures mainly swollen
Completely descend disease, warm disease heating, the disease such as heat toxin large carbuncle and tumour.It is for dizziness, thirst, sweating and boring, enteritis, bacterium
Dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer boils, erysipelas, the parotid gland
The illnesss such as inflammation, suppurative tonsillitis have certain curative effect.
Honeysuckle bine has certain therapeutic effect after stewing water to pruituses such as infant eczemas, to a variety of to sick diseases of livestock and poultry
Bacterium, virus have inhibitory action, if can add honeysuckle cane leaves (caulis lonicerae) powder or pot of doses during animal feeding
Water, warm disease heating, anemopyretic cold, laryngopharyngitis, pneumonia, dysentery, swollen ulcer, erysipelas, honeycomb group to preventing and treating animal
Knit the diseases such as inflammation play the role of it is fairly good.With Fructus Forsythiae, Radix Isatidis, which decocts honeysuckle soup, can treat parotitis；Honeysuckle tea can dispel
Heat improving eyesight；The cool soup of Fructus Forsythiae honeysuckle can treat fever caused by exogenous pathogens cough.Boiling is added to boil honeysuckle, chrysanthemum, campanulaceae and radix glycyrrhizae at the same time
10 minutes, Hou Liang, when beverage is drunk, sphagitis and tonsillitis can be treated.
The Chinese medicine composition that the present invention is prepared by myrrh and honeysuckle compatibility, has effects that clearing heat and detoxicating, scattered blood stagnation resolvation,
The medicament that can be used in treating the Chinese medicine composition is lotion, tincture, finish, emulsion, ointment, emplastrum or gel
Agent.
The present invention further discloses a kind of preparation method of the Chinese medicine composition, comprise the following steps：(1) by each group
Divide mixing, soak；(2) decocted, filtered, collect filtrate, to obtain the final product.
Wherein, the time of step (1) described immersion is 10-60nin；The time of step (2) described decoction is 20-50min,
The number of the decoction is 1-5 times.Preferably, the time of step (1) described immersion is 30nin；Step (2) described decoction when
Between be 30min, the number of the decoction is 3 times；Obtained filtrate mixing will be decocted every time, to obtain the final product.The present invention is to used in immersion
The amount of water is not particularly limited, and does not have medicinal material to be advisable with water.It is of the invention that the amount of water is preferably myrrh and gold and silver used in decoction every time
3 times of 2-10 times of flower gross mass, most preferably myrrh and honeysuckle gross mass.
The comparative result of clinical efficacy shows that the Chinese medicine composition that the present invention is prepared by myrrh and honeysuckle compatibility is to acute
Eczema has exact therapeutic effect, treats the obvious effective rate of acute eczema up to 90%, and total effective rate is up to 100%；Its obvious effective rate and total
The efficient Chinese medicine composition apparently higher than other bulk pharmaceutical chemicals compatibilities preparation such as myrrh and kuh-seng or Cortex Phellodendri, has been respectively increased 20
It is more than percentage point.Result above proves there is obvious synergistic function between myrrh and honeysuckle.In addition, in the present invention
Drug composition has no toxic side effect, take Chinese medicine composition of the present invention eczema patients do not occur over the course for the treatment of it is bad anti-
Should.
Clinical diagnosis applies the Chinese medicine composition of the invention prepared by myrrh and honeysuckle compatibility for the patient of acute eczema,
For the obvious effective rate for the treatment of 14 days up to 90%, total effective rate is curative for effect up to 100%.
The invention also discloses purposes of the Chinese medicine composition in the medicine for preparing treatment eczema.Wherein, it is described
Eczema includes：Acute eczema, subacute eczema and chronic eczema；Preferably acute eczema.
Suitable auxiliary material or carrier are added on the basis of Chinese medicine composition of the present invention can be prepared into different dosage forms
Treatment eczema medicine.The formulation of the medicine includes but not limited to：Lotion, tincture, finish, emulsion, ointment, emplastrum
Or gelling agent.
Bulk pharmaceutical chemicals myrrh, honeysuckle used in the present invention can be commercially available in pharmacy.
The usage and dosage of Chinese medicine composition of the present invention：The present invention dosage depend on specific formulation, patient age,
The factors such as health status.As guidance, usage and dosage：It is dose to take myrrh 30g, honeysuckle 30g, is applied with decocting liquid；Often
Day coating 3 times, 7 days as a course for the treatment of.For obstinate eczema, the dosage of myrrh and honeysuckle can add to 50g in every dose of medicine.
Technical solution of the present invention compared with prior art, has the advantages that：
The compatibility of Chinese medicine composition of the present invention is reasonable, has obvious synergistic work between bulk pharmaceutical chemicals myrrh and honeysuckle
With, can significantly improve treatment eczema obvious effective rate and total effective rate.The preparation process of Chinese medicine composition of the present invention is simple, nontoxic
The effect of side effect, treatment eczema, is definite, has a good application prospect.
Embodiment
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.It should be understood that the embodiment is only exemplary, any restrictions are not formed to the scope of the present invention.This area
Technical staff should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and
Form is modified or replaced, but these modifications or substitutions each fall within protection scope of the present invention.
The preparation of 1 gel preparation of embodiment
Each component (g) is weighed according to following ratio：Myrrh 30, honeysuckle 40；
Preparation method comprises the following steps：
(1) myrrh and honeysuckle are mixed, adds 3 times of amount water immersion 10nin；
(2) decoct 3 times, each 30min, merge decocting liquid, be concentrated into 1g medicinal materials/ml；
(3) matrix is prepared：5-15 parts of Acritamer 940s are soaked in 500-1500 parts of distilled water, add 5-15 parts of glycerine,
After grinding uniformly, 5-10 parts of propane diols are added, uniformly placement a period of time to matrix profit is again stirring for and rises completely；
(4) pH value is adjusted：Decocting liquid obtained by step (2) is added, then adds pH adjusting agent triethanolamine, is stirred evenly, controls pH
It is worth for 5-7；
(5) finished product：5-15 parts of ethylparabens are finally added in the mixed solution obtained by step (4), mixes, fully stir
Mix, sterilize, obtain clear gel, finished product is made in encapsulation.
Usage and dosage：Smearing 3 times daily, in the morning, afternoon and evening respectively once.
The preparation of 2 lotion of embodiment
Each component (g) is weighed according to following ratio：Myrrh 30, honeysuckle 30；
Preparation method comprises the following steps：
(1) myrrh and honeysuckle are mixed, adds 3 times of amount water immersion 20nin；
(2) decoct 2 times, each 40min, merge decocting liquid, be concentrated into 100ml；
Usage and dosage：Apply 3 times, each 30min per daily gauze, in the morning, afternoon and evening it is each once.
The preparation of 3 emulsion of embodiment
Each component (g) is weighed according to following ratio：Myrrh 30, honeysuckle 40；
(1) myrrh and honeysuckle are mixed, adds 3 times of amount water immersion 20nin；
(2) decoct 2 times, each 30min, merge decocting liquid, be concentrated into 200ml；
(3) albolene 100g, octadecyl alcolol 100g, Tween-80 45g, Arlacel-40 27g, glycerine 50g, liquid stone are weighed
Wax 60g, lactic acid 2.8g, distill appropriate amount of water, 1000g are made.
Usage and dosage：Coating 3 times daily, in the morning, afternoon and evening respectively once.
The effect observation of 1 traditional Chinese medicine composition for treating eczema of test example
Patient 420 is selected from Dermatology Outpatient Department, all patients meet the diagnostic criteria of acute eczema and meet main
The characteristics of skin lesion symmetry.Wherein male is 70, and women is 60, age reckling 15 years old, the maximum 65 years old, average age
For (38.02 ± 16.37) year.The most short person of the course of disease is 1 week, and the course of disease most elder is 3 years, and average course of disease is a for (3.25 ± 12.18)
Month.
Chinese medicine composition 1：Myrrh 30, honeysuckle 30；
Chinese medicine composition 2：Myrrh 30, windproof 30；
Chinese medicine composition 3：Myrrh 30, Cortex Phellodendri 30；
Chinese medicine composition 4：Myrrh 30, frutus cnidii 30；
Chinese medicine composition 5：Myrrh 30, kuh-seng 30；
Chinese medicine composition 6：Myrrh 30, the coptis 30；
Chinese medicine composition 7：Myrrh 30, purslane 30；
Chinese medicine composition 8：Myrrh 30, the fruit of summer cypress 30；
Chinese medicine composition 9：Myrrh 30, Asian puccoon 30；
Chinese medicine composition 10：Myrrh 30, curcuma zedoary 30；
Chinese medicine composition 11：Myrrh 30, radix scutellariae 30；
Chinese medicine composition 12：Myrrh 30, Rhizoma Atractylodis Macrocephalae 30；
Chinese medicine composition 13：Myrrh 30, oriental wormwood 30；
The preparation method of each Chinese medicine composition is with embodiment 2, usage and dosage：Each Chinese medicine composition is applied, daily coating
Three times, in the morning, afternoon and evening it is each once；To treat 7d as 1 course for the treatment of, curative effect is counted after 2 courses for the treatment of.Control group, smears deionization
Water, the same test group of usage.
Efficacy assessment standard：
It is effective：The malaise symptoms disappear or mostly disappear such as original disease；
Effectively：The malaise symptoms such as original disease mitigate or partial disappearance；
It is invalid：Even original disease malaise symptoms do not mitigate, aggravate.
The comparative result of clinical efficacy is shown in Table 1.
Total effective rate/%=obvious effective rates+effective percentage.
The effect of the different traditional Chinese medicine composition for treating eczemas of table 1
The result shows that Chinese medicine composition 1 is notable to the therapeutic effect of acute eczema, the patient of Chinese medicine composition 1 is taken, is shown
Imitate 27 people, obvious effective rate 90%；Effective 3 people, effective percentage are 10%, and total effective rate is up to 100%；Its obvious effective rate and total effective rate are bright
The aobvious Chinese medicine composition higher than other bulk pharmaceutical chemicals compatibilities preparation such as myrrh and Cortex Phellodendri, is respectively increased nearly more than 14 percentage points.With
Above the results show that having obvious synergistic function between myrrh and honeysuckle.Moreover, coating Chinese medicine composition 1 of the present invention
Eczema patients do not occur serious adverse reaction in the treatment.
Claims (10)
1. a kind of Chinese medicine composition for treating eczema, it is characterised in that including following each component：Myrrh and honeysuckle.
2. Chinese medicine composition described in accordance with the claim 1, it is characterised in that the parts by weight of each component are：20-50 parts of myrrh,
20-50 parts of honeysuckle.
3. Chinese medicine composition described in accordance with the claim 1, it is characterised in that the parts by weight of each component are：30 parts of myrrh, gold and silver
Spend 30 parts.
4. Chinese medicine composition described in accordance with the claim 1, it is characterised in that the eczema includes：It is acute eczema, subacute wet
Rash and chronic eczema；Preferably acute eczema.
5. the preparation method of Chinese medicine composition described in a kind of Claims 1-4 any one, it is characterised in that including following step
Suddenly：(1) each component is mixed, soaked；(2) plus water is decocted, and is filtered, and collects filtrate, to obtain the final product.
6. according to the preparation method described in claim 5, it is characterised in that：The time of step (1) described immersion is 10-60nin；
The time of step (2) described decoction is 20-50min, and the number of the decoction is 1-5 times；Preferably, water used in decocting every time
Measure as 2-10 times of each component gross mass.
7. according to the preparation method described in claim 5, it is characterised in that：The time of step (1) described immersion is 30nin；Step
Suddenly the time of (2) described decoction is 30min, and the number of the decoction is 3 times；Preferably, the amount of water is each used in decocting every time
3 times of component gross mass.
8. purposes of the Chinese medicine composition in the medicine for preparing treatment eczema described in Claims 1-4 any one.
9. according to the purposes described in claim 8, it is characterised in that the eczema includes：Acute eczema, subacute eczema and slow
Property eczema；Preferably acute eczema.
10. according to the purposes described in claim 8, it is characterised in that the formulation of the medicine includes：Lotion, tincture, finish,
Emulsion, ointment, emplastrum or gelling agent.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110624044A (en) * | 2019-08-30 | 2019-12-31 | 安徽唐人药业有限公司 | Gel disinfectant for treating eczema and preparation method thereof |
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|---|---|---|---|---|
| CN101167847A (en) * | 2007-11-13 | 2008-04-30 | 杨春常 | Traditional Chinese medicinal white spirit preparation for effectively treating skin disease |
| CN103893517A (en) * | 2014-04-12 | 2014-07-02 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicinal mixture for treating dermatitis and eczema |
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Application publication date: 20180420 |