CN106237030A - A kind of Chinese medicine composition treating infant eczema and preparation method thereof - Google Patents
A kind of Chinese medicine composition treating infant eczema and preparation method thereof Download PDFInfo
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- CN106237030A CN106237030A CN201610742992.4A CN201610742992A CN106237030A CN 106237030 A CN106237030 A CN 106237030A CN 201610742992 A CN201610742992 A CN 201610742992A CN 106237030 A CN106237030 A CN 106237030A
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a kind of Chinese medicine composition treating infant eczema, its raw material consists of: Radix Arnebiae (Radix Lithospermi) 10 20 parts, Aloe 10 20 parts, Cortex Dictamni 10 20 parts, Radix Sophorae Flavescentis 10 15 parts, Radix Ampelopsis 10 15 parts, conyza blinii 5 10 parts, Radix Ranunculi Ternati 5 10 parts, Herba Schizonepetae 5 10 parts, Caulis Fibraureae 5 10 parts, Herba Centellae 48 parts, Cacumen Platycladi 36 parts.In the Chinese medicine composition of the present invention, selected crude drug wide material sources, have no side effect, use safer；Each raw material reasonable recipe, compatibility science, jointly play the effect of removing damp-heat, removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching, anti-inflammation between medicine, there is obvious potentiation, give full play to the compatibility relationship that mutual reinforcement between makes mutually；The safety of Chinese medicine composition is high, and with strong points, clinical verification determined curative effect can overcome the shortcoming that Western medicine side effect is big.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating infant eczema and preparation method thereof.
Background technology
The infantile eczema traditional Chinese medical science claims infantile eczema, infantile eczema, infantile eczema, and head sees " all source of disease marquis opinion ": clinical manifestation is to send out baby head well
Face, millet in shape, it is dispersed in or intensive, hazel color is red, has scratched white scales；Or broken stream Jin Shui, contamination is feature in flakes.The former belongs to wind
Intenseness of heat, the latter lays particular stress on damp and hot Sheng.Its pathogenesis is that natural disposition is weak to, and bears a pretty, delicate skin, transporting and transforming function of the spleen and stomach mistake department, inside has tire fire damp and hot, is subject to outward
Rheumatism pathogenic heat is invaded, and accumulates resistance skin and causes.
Modern medicine thinks that the cause of disease of infantile eczema is mainly relevant with inherited genetic factors and environmental factors and allergy.Due to
Skin pruritus, infant often shows as crying and screaming, insomnia, Yi Xing, thus can not get fully having a rest, and the time is longer so that impact is raw
Long growth.Therefore should as early as possible infantile eczema be treated, to early recovery.At present, the most also without comparatively ideal treatment
Medicine, conventional processing mode for avoiding contact with stimulus object, antiinflammatory, convergence, antipruritic agent symptomatic treatment.In conventional medicine has
The histamine medicine of clothes and external corticosteroids ointment.Antihistamine drug can alleviate skin pruritus symptom, but can not alleviate office
Portion's dermal pathology infringement, shortens the course of disease.External hormone medicine has reasonable curative effect, can substantially alleviate the disease of local skin
Damage, but due to the easily recurrence of this disease, Reusability thinning of skin, pigmentation, facial telangiectasias the most easily occurs, even
The serious adverse reactions such as atrophoderma.Therefore, it is necessary to develop a kind of new medicine safely and effectively treating infant eczema
Preparation.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating infant eczema, this Chinese medicine composition has heat clearing away
Dehumidifying, removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching, effect of anti-inflammation, the treatment to infant eczema is evident in efficacy, and safety non-toxic pair is made
With.
It is a further object of the present invention to provide the preparation method of the Chinese medicine composition of this treatment infant eczema.
For achieving the above object, the present invention uses following technical proposals:
A kind of Chinese medicine composition treating infant eczema, its raw material consists of:
Radix Arnebiae (Radix Lithospermi) 10-20 part, Aloe 10-20 part, Cortex Dictamni 10-20 part, Radix Sophorae Flavescentis 10-15 part, Radix Ampelopsis 10-15 part, gold Radix Gentianae
Grass 5-10 part, Radix Ranunculi Ternati 5-10 part, Herba Schizonepetae 5-10 part, Caulis Fibraureae 5-10 part, Herba Centellae 4-8 part, Cacumen Platycladi 3-6 part.
Preferably, the Chinese medicine composition of described treatment infant eczema is made up of the raw material of following weight parts:
Radix Arnebiae (Radix Lithospermi) 12-18 part, Aloe 14-18 part, Cortex Dictamni 14-16 part, Radix Sophorae Flavescentis 12-14 part, Radix Ampelopsis 12-14 part, gold Radix Gentianae
Grass 6-8 part, Radix Ranunculi Ternati 6-8 part, Herba Schizonepetae 6-8 part, Caulis Fibraureae 6-8 part, Herba Centellae 6-8 part, Cacumen Platycladi 4-6 part.
It is further preferred that the Chinese medicine composition of described treatment infant eczema is made up of the raw material of following weight parts:
Radix Arnebiae (Radix Lithospermi) 18 parts, Aloe 16 parts, Cortex Dictamni 15 parts, Radix Sophorae Flavescentis 13 parts, Radix Ampelopsis 13 parts, conyza blinii 7 parts, Radix Ranunculi Ternati 7 parts,
Herba Schizonepetae 7 parts, Caulis Fibraureae 7 parts, Herba Centellae 7 parts, Cacumen Platycladi 5 parts.
The compatibility of Chinese medicine be particular about mutual reinforcement between, make mutually, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition is conversely, because exist not between different Chinese medicine
Same compatibility relationship, therefore when using the two above Chinese medicine of taste, it is necessary to be allowed a choice, give full play to what mutual reinforcement between medicine made mutually
Compatibility relationship, makes the clinical effectiveness of product be significantly improved.
On the other hand, Chinese medicine ingredients is complicated, existing water soluble ingredient in a kind of medical material, has again oil-soluble or alcohol-soluble to become
Divide, and some active component the most easily inactivates, therefore by selecting suitable extracting method and extraction process to Chinese medicine
Effective ingredient carries out extracting separation, can extract effective ingredient to greatest extent and ensure the activity of effective ingredient, thus protecting
The clinical effectiveness of card product.
The present invention, by kinds of traditional Chinese medicines is carried out compatibility, has jointly played removing damp-heat, removing pathogenic heat from blood and toxic substance from the body, has dispeled the wind between medicine
Antipruritic, the effect of anti-inflammation, has obvious potentiation, has given full play to the compatibility relationship that mutual reinforcement between makes mutually.In compositions
The pharmacology analysis of each component is as follows:
Radix Arnebiae (Radix Lithospermi): sweet, salty, cold.GUIXIN, Liver Channel.Clearing away heat and cooling blood, promoting blood circulation and detoxication, rash speckle removing.Contain for heat in blood poison, macule
Purple black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Aloe: bitter, cold.Return liver, stomach, large intestine channel.Relieving constipation by purgation, purging liver-fire, parasite killing treats infantile malnutrition.For constipation with heat retention, frightened
Epilepsy is twitched, infantile malnutrition, external treatment tinea skin ulcer.
Cortex Dictamni: bitter, cold.Return spleen, stomach, bladder warp.Heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping,
Eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
Radix Sophorae Flavescentis: bitter, cold.GUIXIN, liver, stomach, large intestine, bladder warp.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, yellow
Subcutaneous ulcer urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Radix Ampelopsis: bitter, is slightly cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation.For carbuncle carbuncle on the back, furuncle,
Scrofula, burn and scald.
Conyza blinii: bitter, cold.Return lung, Liver Channel.Removing heat-phlegm, relieving cough and asthma, detoxification and promoting urination, cooling blood for hemostasis.For lung-heat
Cough, abundant expectoration asthma, pharyngalgia, aphtha, jaundice due to damp-heat, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage.
Radix Ranunculi Ternati: sweet, acrid, warm.Return liver, lung meridian.Dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling.For scrofula sucutaneous nodule, furuncle swelling toxin, Serpentis
Insect bite is hindered.
Herba Schizonepetae: pungent, tepor.Return lung, Liver Channel.Induce sweat scattered wind, rash, and disappear skin ulcer.For catching a cold, headache, measles, rubella, skin ulcer
Infections from the beginning of.
Caulis Fibraureae: bitter, cold.GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, pathogenic fire purging relieving constipation.For dominance of heat in the interior, constipation, dysentery, swelling throat
Bitterly, conjunctival congestion is red and swollen, carbuncle sore tumefacting virus.
Herba Centellae: bitter, acrid, cold.Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea,
Stranguria caused by urinary stone stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
Cacumen Platycladi: bitter, puckery, cold.Return lung, liver, spleen channel.Cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair.For spitting blood, nosebleed
Blood, spitting of blood, have blood in stool, metrostaxis, cough due to lung-heat, heat in blood alopecia, early whitening of beard and hair.
The present invention treatment infant eczema Chinese medicine composition in, each component through dialectical compatibility, phase in drug action
Assistant helps mutually, and Fang Zhong: Radix Arnebiae (Radix Lithospermi), Aloe and Cortex Dictamni can be the most collaborative, and gain is complementary, plays more preferable heat clearing and damp drying, only dispels the wind
Itch, the effect of anti-inflammation；Radix Sophorae Flavescentis, Radix Ampelopsis, conyza blinii and Caulis Fibraureae play the effect of cooling blood for hemostasis, removing toxic substances and promoting subsidence of swelling；Herba Schizonepetae, long-pending
Snow grass and Cacumen Platycladi can strengthen the effect of clearing away heat-fire, anti-inflammation；Each component synergism, plays heat-clearing and toxic substances removing, dehumidifying altogether
Antipruritic, anti-inflammation, effect of reparation skin barrier.
In the Chinese medicine composition of the treatment infant eczema of the present invention, each raw material components is an organic whole, lacks one
Can not.Inventor finds in R&D process, reduces any one of above-mentioned composition raw material components, or to have similar medicine
Property crude drug the raw material components of Chinese medicine composition of the present invention is replaced, then the action effect that Chinese medicine composition is overall is notable
Reduce；Being further added by other raw material components on the basis of the compositions of the present invention, the whole structure of compositions does not have substantially
Improvement, even have the situation that the whole structure of compositions reduces to occur.
Above-mentioned Chinese medicine composition is prepared by the following method and obtains, and step is as follows:
By Radix Arnebiae (Radix Lithospermi), Aloe, Cortex Dictamni, Radix Sophorae Flavescentis, Radix Ampelopsis, conyza blinii, Radix Ranunculi Ternati, Herba Schizonepetae, Caulis Fibraureae, Herba Centellae and Cacumen Platycladi
Mixing, boiling twice, filter and (add 8 times amount water for the first time, decoct 2 hours；Second time adds 6 times amount water, decocts 1.5 little
Time), merging filtrate, it is concentrated into the extractum that relative density is 1.1 (50 DEG C), to obtain final product.
Experiment proves that, use above-mentioned preparation method, the effective one-tenth in Chinese medicine composition can be extracted to greatest extent
Divide and ensure the activity of effective ingredient, thus ensure the clinical effectiveness of product.
The application in the pharmaceutical preparation of preparation treatment infant eczema of the above-mentioned Chinese medicine composition is also that the present invention protects
Scope.
Second aspect present invention, it is provided that the pharmaceutical preparation of a kind for the treatment of infant eczema, by above-mentioned Chinese medicine composition
It is prepared from pharmaceutically acceptable adjuvant.
Said medicine preparation can make various pharmaceutical dosage form, such as gel, spray, lotion, emulsifiable paste/cream, powder
Deng.
Described pharmaceutically acceptable adjuvant is the customary adjuvant in pharmaceutical preparation, preferably glycerol, butanediol, Sargassum
One or more in sugar, glycine betaine, starch, sodium carboxymethyl cellulose.
Beneficial effects of the present invention:
(1) in the Chinese medicine composition of the present invention, selected crude drug wide material sources, have no side effect, use and more pacify
Entirely；Each raw material reasonable recipe, compatibility science, jointly play removing damp-heat, removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching, antibacterial between medicine
The effect of antiinflammatory, has obvious potentiation, has given full play to the compatibility relationship that mutual reinforcement between makes mutually；The safety of Chinese medicine composition
Height, with strong points, clinical verification determined curative effect, the shortcoming that Western medicine side effect is big can be overcome.
(2) Chinese medicine composition of the present invention can be prepared as acceptable gel, spray, lotion, breast clinically
Various dosage form such as cream/cream, powder etc..Not only maintain the intrinsic effective substance of said composition and clinical efficacy, Er Qiefang
Just use, carry.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, it should explanation, the description below be only for
The explanation present invention, is not defined its content.
Embodiment 1:
[formula]
Radix Arnebiae (Radix Lithospermi) 18 grams, Aloe 16 grams, Cortex Dictamni 15 grams, Radix Sophorae Flavescentis 13 grams, Radix Ampelopsis 13 grams, conyza blinii 7 grams, Radix Ranunculi Ternati 7 grams,
Herba Schizonepetae 7 grams, Caulis Fibraureae 7 grams, Herba Centellae 7 grams, Cacumen Platycladi 5 grams.
[preparation method]
By Radix Arnebiae (Radix Lithospermi), Aloe, Cortex Dictamni, Radix Sophorae Flavescentis, Radix Ampelopsis, conyza blinii, Radix Ranunculi Ternati, Herba Schizonepetae, Caulis Fibraureae, Herba Centellae and Cacumen Platycladi
Mixing, boiling twice, filter and (add 8 times amount water for the first time, decoct 2 hours；Second time adds 6 times amount water, decocts 1.5 little
Time), merging filtrate, it is concentrated into the extractum that relative density is 1.1 (50 DEG C), the Chinese medicine composition of infant eczema must be treated.
Then this Chinese medicine composition is made gel in conventional manner.
Embodiment 2:
[formula]
Radix Arnebiae (Radix Lithospermi) 10 grams, Aloe 20 grams, Cortex Dictamni 10 grams, Radix Sophorae Flavescentis 15 grams, Radix Ampelopsis 10 grams, conyza blinii 10 grams, Radix Ranunculi Ternati 5
Gram, Herba Schizonepetae 10 grams, Caulis Fibraureae 5 grams, Herba Centellae 8 grams, Cacumen Platycladi 3 grams.
The preparation method of Chinese medicine composition, with embodiment 1, is prepared as spray the most in conventional manner.
Embodiment 3:
[formula]
Radix Arnebiae (Radix Lithospermi) 20 grams, Aloe 10 grams, Cortex Dictamni 20 grams, Radix Sophorae Flavescentis 10 grams, Radix Ampelopsis 15 grams, conyza blinii 5 grams, Radix Ranunculi Ternati 10
Gram, Herba Schizonepetae 5 grams, Caulis Fibraureae 10 grams, Herba Centellae 4 grams, Cacumen Platycladi 6 grams.
The preparation method of Chinese medicine composition, with embodiment 1, is prepared as lotion the most in conventional manner.
Embodiment 4:
[formula]
Radix Arnebiae (Radix Lithospermi) 12 grams, Aloe 18 grams, Cortex Dictamni 14 grams, Radix Sophorae Flavescentis 14 grams, Radix Ampelopsis 12 grams, conyza blinii 8 grams, Radix Ranunculi Ternati 6 grams,
Herba Schizonepetae 8 grams, Caulis Fibraureae 6 grams, Herba Centellae 8 grams, Cacumen Platycladi 4 grams.
The preparation method of Chinese medicine composition, with embodiment 1, is prepared as emulsifiable paste the most in conventional manner.
Embodiment 5:
[formula]
Radix Arnebiae (Radix Lithospermi) 18 grams, Aloe 14 grams, Cortex Dictamni 16 grams, Radix Sophorae Flavescentis 12 grams, Radix Ampelopsis 14 grams, conyza blinii 6 grams, Radix Ranunculi Ternati 8 grams,
Herba Schizonepetae 6 grams, Caulis Fibraureae 8 grams, Herba Centellae 6 grams, Cacumen Platycladi 6 grams.
The preparation method of Chinese medicine composition, with embodiment 1, is prepared as cream the most in conventional manner.
Prepared by the present invention has the superfine powder chewable tablet of beauty treatment weight reducing effect, and Analyses Methods for Sensory Evaluation Results is as follows:
Comparative example 1:
The present inventor in R&D process, the multi-flavor crude drug with the close property of medicine has been carried out compatibility relationship investigation and
The research of drug effect, even if it was found that the property of medicine between a few taste crude drug is similar, but the crude drug compatibility different from other makes
With rear, its effect significant difference.Such as: the Radix Arnebiae (Radix Lithospermi) in the pharmaceutical formulation of embodiment 1 is replaced with Herba Portulacae, Aloe is replaced
It is changed to Radix Tinosporae, Cortex Dictamni is replaced with Cortex Moutan, conyza blinii is replaced with Herba Sedi, Radix Ranunculi Ternati is replaced with Spica Prunellae, will
Caulis Fibraureae replaces with Radix Boehmeriae, and remaining is with embodiment 1；
Adopt and prepare with the following method:
By Herba Portulacae, Radix Tinosporae, Cortex Moutan, Radix Sophorae Flavescentis, Radix Ampelopsis, Herba Sedi, Spica Prunellae, Herba Schizonepetae, Radix Boehmeriae, Herba Centellae and Cacumen Platycladi
Leaf mixes, boiling twice, filters and (adds 8 times amount water for the first time, decoct 2 hours；Second time adds 6 times amount water, decocts 1.5 little
Time), merging filtrate, it is concentrated into the extractum that relative density is 1.1 (50 DEG C), to obtain final product.
The test of animal eczema shows, the therapeutic effect comparative example to be significantly better than of the Chinese medicine composition of the embodiment of the present invention 1
1.Illustrate that the compositions of the present invention meets the compatibility relationship of Chinese medicine, there is between each component collaborative facilitation, not have
The simple of the crude drug of the similar property of medicine is replaced or combination.
Comparative example 2:
In Chinese medicine composition, the dose of each crude drug is the mark efficacy of a drug, even if the medicine composition of prescription is identical, if but medicine
The consumption of thing is different, and its efficacy of a drug then has dividing of size, and compatibility relationship then has the change of monarch, thus its merit cures mainly the most each
The most different.The present inventor's content to each raw material in Chinese medicine composition in R&D process has carried out grinding of investigation and drug effect
Studying carefully, it was found that the difference of deal shared by inappropriate proportioning raw materials relation, especially monarch drug and ministerial drug, its effect is poor
The most notable.Such as: the consumption of Radix Arnebiae (Radix Lithospermi) in embodiment 1 is adjusted to 5 grams, the consumption of Aloe be adjusted to 25 grams, the consumption of Cortex Dictamni
Be adjusted to 5 grams, the consumption of Radix Sophorae Flavescentis be adjusted to 5 grams, the consumption of Radix Ampelopsis be adjusted to 20 grams, the consumption of other raw materials with embodiment 1, and
Prepare as described in Example 1.
The test of animal eczema shows, the therapeutic effect comparative example to be significantly better than of the Chinese medicine composition of the embodiment of the present invention 1
2.Illustrate that the adjustment institute that in the compositions of the present invention, the consumption of each crude drug is not conventional is getable, the Chinese drug-treated group of the present invention
Fang Zhong, the consumption proportion of each raw medicinal material determines according to various Considerations such as its character of medicinal material, monarch compatibilities, right
Overall drug effect in Chinese medicine composition plays very important effect.
Safety testing:
1. Skin Irritation Test:
Taking healthy rabbits 16, before being administered, family's rabbit back spinal column diamond wool is cut off by 24h.It is randomly divided into two groups, often organizes 8
Only.The fur that one treated animal goes during test hair-fields weares and teares with sterilization sand paper, and is divided into little " well " shape to oozing of blood with sterilization syringe needle
As damaged skin group, another group is intact skin group.It is coated with the gel about 1.5g prepared by the embodiment of the present invention 1 in left side,
Right side is coated with excipient about 1.5g and compares.Cover antistaling film, immobilization with adhesive tape after administration, keep medicine and contact skin 6h, so
After wash away left drug with warm water.It is administered every day 2 times, continuous 2 weeks.Intact skin group is in kind administered.Last removes medicine
After thing, 1,24,48 and 72h observe and record and smear position with or without erythema and edema and recovery situation, by " Chinese medicine, natural drug office
Portion's zest and hemolytic investigative technique guideline " evaluate the pharmaceutical composition successive administration of the present invention to complete and damaged skin
The stimulus intensity of skin, the recovery situation of irritant reaction and time, and compare with matched group.
2. skin allergy test:
Take healthy guinea pig 20, male and female half and half, be randomly divided into 4 groups by body weight, often group 5, before experiment on the left of each animal of 24h
Lose hair or feathers about 2.5cm × 3cm at back.It is administered treated animal and is coated with the gel prepared by the embodiment of the present invention 1, every Mus 1g respectively；Empty
White matched group is coated with excipient, every Mus 1g；Positive drug control group is coated with l%2,4-dinitrochlorobenzene, every Mus 0.4ml, then
All coated with edible antistaling film, with immobilization with adhesive tape, continue 4h.Within 7th day and the 14th day, respectively organize respectively with same method repeat administration 1
Secondary.27th day by unhairing about 2.5cm × 3cm in back on the right side of each Cavia porcellus, after 24h, the 1st, 2, unhairing district is coated with respectively on the right side of 3 treated animals
With ice pungent ointment 1g, excipient 1g and 0.1%2,4-dinitrochlorobenzene 0.2ml.Wash away medicine with warm water after 6h, at once observe,
Then in 24,48,72h again observe skin allergy situation, observe animal with or without the general such as asthma, astasia simultaneously
Anaphylaxis.Evaluate each by " technological guidance's principle that Chinese medicine, natural drug immunotoxicity (anaphylaxis, photoallergy) are studied "
Treated animal skin allergy score value and the sensitization intensity of eczema sport gel, and (sensitization rate was for occurring to calculate sensitization incidence rate
The animal ratio of quick reaction).
Irritation test and sensitivity test result show: the Chinese medicine composition of the present invention is non-stimulated to animal skin
Property, experimental animal, without red and swollen, edema or allergic phenomena, illustrates that the compositions of the present invention uses safety, has no side effect.
Clinical application effect
1. physical data:
Demonstrate infant eczema patient 40 example altogether, be randomly divided into treatment group and matched group, often organize 20 examples, above trouble
The age of person, sex, the course of disease etc. are without significant difference.
2. diagnostic criteria:
Two indexs of indispensability that diagnostic criteria meets in U.S.'s Dermatology meeting atopic dermatitis diagnostic criteria are the most diagnosable.I.e.
(1) pruritus；(2) possessing typical performance and age characteristics, baby face, neck and limbs bend that side is acute, subacute, chronic eczema.
3. Therapeutic Method:
Treatment group: use the gel of the embodiment of the present invention 1 preparation, be applied to affected part, three times a day, each 1-2 gram.
Matched group: using baby's MEIBAO WEIFU GAO of feeling well to treat, by specification uses or follows the doctor's advice.
Using 3 days continuously, every day observes using effect.
4. curative effect judging standard:
Cure: pruritis disappears, and Secondary cases skin lesion disappears completely.
Effective: pruritis substantially alleviates, Secondary cases skin lesion disappears more than 60%.
Invalid: pruritis is without alleviating or increasing the weight of, and Secondary cases skin lesion disappears less than 60%.
5. therapeutic outcome:
Table 1 therapeutic outcome
| Case | Case load | Cure | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 20 | 12 | 7 | 1 | 95 |
| Matched group | 20 | 10 | 6 | 4 | 80 |
As can be seen from Table 1, the Chinese medicine composition (treatment group) of the treatment infant eczema of the present invention is wet for infant
The clinical therapeutic efficacy of rash is notable.And compared with matched group, the pharmaceutical composition of the present invention is rapid-action, at once stops after using
Itching, in 4-24 hour, symptom i.e. disappears (matched group symptom after using 48 hours just disappears).
Claims (8)
1. the Chinese medicine composition treating infant eczema, it is characterised in that its raw material consists of:
Radix Arnebiae (Radix Lithospermi) 10-20 part, Aloe 10-20 part, Cortex Dictamni 10-20 part, Radix Sophorae Flavescentis 10-15 part, Radix Ampelopsis 10-15 part, conyza blinii 5-
10 parts, Radix Ranunculi Ternati 5-10 part, Herba Schizonepetae 5-10 part, Caulis Fibraureae 5-10 part, Herba Centellae 4-8 part, Cacumen Platycladi 3-6 part.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that its raw material consists of:
Radix Arnebiae (Radix Lithospermi) 12-18 part, Aloe 14-18 part, Cortex Dictamni 14-16 part, Radix Sophorae Flavescentis 12-14 part, Radix Ampelopsis 12-14 part, conyza blinii 6-8
Part, Radix Ranunculi Ternati 6-8 part, Herba Schizonepetae 6-8 part, Caulis Fibraureae 6-8 part, Herba Centellae 6-8 part, Cacumen Platycladi 4-6 part.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that its raw material consists of:
Radix Arnebiae (Radix Lithospermi) 18 parts, Aloe 16 parts, Cortex Dictamni 15 parts, Radix Sophorae Flavescentis 13 parts, Radix Ampelopsis 13 parts, conyza blinii 7 parts, Radix Ranunculi Ternati 7 parts, Herba Schizonepetae
7 parts, Caulis Fibraureae 7 parts, Herba Centellae 7 parts, Cacumen Platycladi 5 parts.
4. the preparation method of the Chinese medicine composition described in any one of claims 1 to 3, it is characterised in that step is as follows:
Radix Arnebiae (Radix Lithospermi), Aloe, Cortex Dictamni, Radix Sophorae Flavescentis, Radix Ampelopsis, conyza blinii, Radix Ranunculi Ternati, Herba Schizonepetae, Caulis Fibraureae, Herba Centellae and Cacumen Platycladi are mixed
Close, boiling, filter, merging filtrate, be concentrated into the extractum that relative density is 1.1 (50 DEG C of surveys), to obtain final product.
5. the use in the pharmaceutical preparation of preparation treatment infant eczema of the Chinese medicine composition described in any one of claims 1 to 3
On the way.
6. treat a pharmaceutical preparation for infant eczema, by the Chinese medicine composition described in any one of claims 1 to 3 and pharmacy
Upper acceptable adjuvant is prepared from.
7. pharmaceutical preparation as claimed in claim 6, it is characterised in that described pharmaceutically acceptable adjuvant is selected from glycerol, fourth
One or more in glycol, trehalose, glycine betaine, starch, sodium carboxymethyl cellulose.
8. pharmaceutical preparation as claimed in claim 6, it is characterised in that the dosage form of described pharmaceutical preparation be gel, spray,
Lotion, emulsifiable paste/cream, powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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