CN105641133A - Composition for prevention and treatment of children eczema and preparation method thereof - Google Patents
Composition for prevention and treatment of children eczema and preparation method thereof Download PDFInfo
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Abstract
A composition for prevention and treatment of children eczema comprises, by weight, 30-70 parts of lithospermum, 30-70 parts of coptis chinensis, 5-40 parts of radix gentianae, 5-20 parts of radix sophorae flavescentis, 5-20 parts of cortex dictamni, 30-70 parts of rhubarb, 5-30 parts of fructus gardeniae, 5-20 parts of Rhizoma et Radix Baphicacanthis Cusiae, 5-20 parts of borneol and proper amount of sesame oil and beeswax. The composition is prepared from the lithospermum as a monarch drug by cooperation with the borneol and many other traditional Chinese medicinal materials, specifically aims at children's delicate skin, has the effects of clearing away heat and toxic materials, removing dampness by dieresis and relieve itching, and is mild, non-irritating, hypoallergenic, non-drug-resistance, and readily accepted by children and parents.
Description
Technical field
The composition that the present invention relates to a kind of processing by plant and make, particularly relating to a kind of take Asian puccoon as the Chinese medicine ointment of monarch's medicine, for the control of eczema, especially Children's diaper dermatitis.
Background technology
Infantile eczema is commonly called as infantile eczema, is a kind of have the skin inflammation reaction obviously oozing out tendency by what multiple factor caused, falls ill in the baby in 1��June, and affected part itch is hard to bear so that baby's agitation, uneasiness of crying and screaming, bring many worries to infant and the head of a family. Infant eczema sickness rate has the trend of rising in recent years, and touching does not heal, recurrent exerbation. Eczema medication in existing market divides Chinese medicine and two kinds, Western medicine, Western medicine many employings oral antihistamines and external application hormones Ointment in Treatment, though effective in cure, but side effect is big, and untoward reaction is many, and stops medicine and easily recur, and is not suitable for baby and uses.
Chinese invention patent application 201010538080.8 discloses a kind of lotion treating eczema, looked for the kinds of traditional Chinese medicines material such as 20-30 part and kuh-seng 20-40 part made by rhizoma atractylodis 30-40 part, bletilla striata 30-40 part, Turkey-galls 30-40 part, rheum officinale 10-30 part, Rhizome of Grass leaf Sweelflag 20-40 part, golden cypress 10-30 part, Asian puccoon 10-30 part, Root-bark of Densefruit Pittany 20-40 part, horse tooth, the treatment of multiple eczema can be used for.
Chinese invention patent application 201410311388.7 discloses a kind of traditional Chinese medicinal ointment treating infantile eczema, by Asian puccoon 30-35 part, root of large-flowered skullcap 12-18 part, coptis 12-18 part, root of Dahurain angelica 20-25 part, Japanese Honeysuckle Stem 20-25 part, rheum officinale 12-16 part, cape jasmine 12-18 part, peppermint 12-16 part, golden cypress 12-18 part, gypsum 10-15 part, Poria cocos 10-15 part, bighead atractylodes rhizome 8-12 part, Fructus Aurantii 8-12 part, Fruit of Belveder 8-12 part, Japanese Honeysuckle 12-18 part, Leaf of Indigowoad 12-18 part, fructus amomi 16-18 part, Root of Chinese Pulsatilla 16-18 part and borneol 15-20 part etc. are made, the improvement rate of infantile eczema is reached more than 95%.
The medicine that Chinese invention patent application 201210300607.2 discloses a kind of infant's for the treatment of erythema, eczema and festers, by Chinese medicinal materialss such as Asian puccoon 10 grams, frankincense 6 grams, myrrh 6 grams, 8 grams, catechu, the root of Dahurain angelica 12 grams, giant knotweed 12 grams, the root of large-flowered skullcap 9 grams and rheum officinales 10 grams, add in boiled peanut oil (or sesame oil), after coke yellow, leave standstill, after temperature decrease to room temperature, more appropriate borneol is added wherein, and stir and evenly obtain afterwards. Infant's skin is without any side effects, successful.
Summary of the invention
It is an object of the present invention to provide a kind of Chinese medicinal materials composition, for the prevention and therapy of eczema.
Another object of the present invention is to provide a kind of composition being made up of several kinds of Chinese medicinal materials, or taking it as activeconstituents, coordinates and add other auxiliary material, for the preparation of the preparation of prevention and therapy eczema.
It is yet a further object of the present invention to provide a kind of is the method that medicine portion produces preparation taking several kinds of Chinese medicinal materials, is convenient in the prevention and therapy of children's eczema and uses.
" prevention " alleged by the present invention refers to before the disease do not assert by clinical criteria, various for preventing means or the measure of disease generation or development, comprises the method for medical science, physics or chemistry, to stop and to reduce generation or the development of the various symptom of disease.
" treatment " alleged by the present invention refers to generation or the development in order to stop and reduce disease, make the development of disease course or increase the weight of to be suppressed, contain, alleviate, improve, slow down, stop, postponing or reverse, various indexs that are disease when described maintenance or medication, disorderly or pathologic state comprise and alleviate or reduces symptom or complication, or cure or elimination disease, disorder or situation.
" preparation " alleged by the present invention refers to the formulation being conducive to administration containing each kind of plant provided by the invention and extract thereof and reactive site, as: but be not limited only to, aqueous solution injection, powder injection, pill, powder, tablet, patch, suppository, emulsion, frost agent, gelifying agent, granule, capsule, aerosol, sprays, powder inhalation, sustained release dosage and control-released agent etc. These pharmaceutical excipients both can be conventional in various preparation use, as: but be not limited only to, wait penetration enhancer, damping fluid, correctives, vehicle, weighting agent, tackiness agent, disintegrating agent and lubricant etc.; Can also in order to adapt and choice for use with described material, as: emulsifying agent, solubilizing agent, fungistat, pain killer and oxidation inhibitor etc., this kind of auxiliary material can effectively improve the stability of compound contained by composition and the rate of release of solvability or change compound and uptake rate etc., thus improve the metabolism of the compounds of this invention in organism, and then strengthen administering effect. In addition, can also for realizing specific administration object or mode, as: sustained-release administration, controlled release drug administration and pulsatile administration etc., and the auxiliary material used, as: but be not limited only to, gelatin, albumin, chitosan, polyethers and polyester macromolecular material, as: but be not limited only to, polyoxyethylene glycol, urethane, polycarbonate and multipolymer thereof etc. The main performance of alleged " being conducive to administration " has: but be not limited only to improve result for the treatment of, raising bioavailability, reduce toxic side effect and improve patient's conformability etc.
" Asian puccoon " alleged by the present invention is Boraginaceae Lithospermum plant, nature and flavor bitter cold, thoughts of returning home envelope, Liver Channel. It is used as medicine and can be used for prevention measles, treatment anaphylactoid purpura, treatment thrombopenic purpura, treatment herpes simplex, controls burning hot and caused by it foaming and rot, controls ulcer and just close and treat the illnesss such as five subcutaneous ulcers heat are yellow, plays clearing heat and detoxicating with effect that is promoting blood circulation and cooling blood. Available its is monarch's medicine, consumption is 30 weight part��70 weight parts, especially 50 weight part��70 weight part, cure mainly the diseases such as burn, eczema, erysipelas, large carbuncle and macula, as: but it is not limited only to 50 weight parts, 52 weight parts, 55 weight parts, 58 weight parts, 60 weight parts, 62 weight parts, 65 weight parts, 68 weight parts and 70 weight parts.
The present invention alleged " coptis " is Ranunculaceae Coptis per nnial herb, bitter cold in nature, the thoughts of returning home, liver, stomach and large intestine channel, there is eliminating fire and detoxication and removing dampness and killing parasites effect, full for damp and hot ruffian, vomit acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, blood-head tell nosebleed, hot eyes, have a toothache, quench one's thirst and carbuncle swells the diseases such as furunculosis;Control the swollen furunculosis of carbuncle, the wet disease such as sore and empyrosis of eczema outward. Available its is ministerial drug, consumption is 30 weight part��70 weight parts, especially 30 weight part��50 weight part, as: but it is not limited only to 30 weight parts, 32 weight parts, 35 weight parts, 38 weight parts, 40 weight parts, 42 weight parts, 45 weight parts, 48 weight parts and 50 weight parts.
The present invention's alleged " rough gentian " is gentianaceae plant, and nature and flavor bitter cold, returns liver, gallbladder channel. Heat-clearing and damp-drying drug, can purging the liver of pathogenic fire courage excess fire. External application cures mainly carbuncle swollen sore, eczema itch. Available its is ministerial drug, consumption is 5 weight part��40 weight parts, especially 20 weight part��40 weight part, as: but it is not limited only to 20 weight parts, 22 weight parts, 25 weight parts, 28 weight parts, 30 weight parts, 32 weight parts, 35 weight parts, 38 weight parts and 40 weight parts.
The plant that the present invention's alleged " kuh-seng " belongs to for pulse family kuh-seng, nature and flavor bitter cold, returns liver, kidney, large intestine and small intestine warp. Tool heat-clearing and damp-drying drug, the effect killing worm diuresis. External application cures mainly eczema, skin pruritus, mange leprosy, trichomonal vaginitis. Available its is ministerial drug, and consumption is 5 weight part��20 weight parts, as: but it is not limited only to 5 weight parts, 7 weight parts, 10 weight parts, 12 weight parts, 15 weight parts, 18 weight parts and 20 weight parts.
The present invention's alleged " Root-bark of Densefruit Pittany " is the root skin of Rutaceae per nnial herb shaggy-fruited dittany and Dictamnus angustifolius, and nature and flavor bitter cold, returns spleen and stomach warp, has heat-clearing and damp-drying drug and timid wind detoxicating functions. Cure mainly the diseases such as the rubella caused by the wet poison of wind-heat, eczema, mange, jaundice and damp and hot numbness. Available its is ministerial drug, and consumption is 5 weight part��20 weight parts, as: but it is not limited only to 5 weight parts, 7 weight parts, 10 weight parts, 12 weight parts, 15 weight parts, 18 weight parts and 20 weight parts.
The perennial plant that the present invention's alleged " rheum officinale " is polygonaceae Rheum, wherein water chestnut rheum officinale Chang Zuowei is medicinal, has another name called south rheum officinale, and nature and flavor bitter cold, returns stomach, large intestine and Liver Channel, has and attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, effect such as the stasis of blood and removing toxic substances of dispelling. Available its is adjutant, consumption is 30 weight part��70 weight parts, especially 30 weight part��50 weight part, as: but it is not limited only to 30 weight parts, 32 weight parts, 35 weight parts, 38 weight parts, 40 weight parts, 42 weight parts, 45 weight parts, 48 weight parts and 50 weight parts.
The present invention alleged " cape jasmine " is madder wort, nature and flavor bitter cold, the thoughts of returning home, liver, lung and stomach warp. There is purging intense heat relieving restlessness, clearing away heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, protect liver, profit courage, step-down, calmness, the effect such as hemostasis and detumescence. External application cures mainly fire, and sore does not rise, sore swells and ache, burn, pathogenic fire,toxin and furuncles and sprain and contusion pain etc. Available its is adjutant, consumption is 5 weight part��30 weight parts, especially 10 weight part��30 weight part, as: but it is not limited only to 10 weight parts, 12 weight parts, 15 weight parts, 18 weight parts, 20 weight parts, 22 weight parts, 25 weight parts, 28 weight parts and 30 weight parts.
The present invention's alleged " rhizoma et Radix Baphicacanthis Cusiae " is Acanthaceae per nnial herb, and nature and flavor are bitter, cold, the thoughts of returning home, liver and stomach warp, has clearing heat and detoxicating and cool blood and subsides a swelling effect. Cure mainly maculae caused by violent heat pathogen, the headache of high heat, major part pestilence, erysipelas, mumps, viral hepatitis, influenza, pneumonia, sore swell and the disease such as bleb. In its pan-fried soup, dose is generally 15 grams��30 grams, heavy dose of available to 60 grams��120 grams. Or appropriate, smash and apply or pan-fried soup is smoked washes external application. ?end vexed ? sacrifical grain in ancient times ? ? Mei Ke ? weight part��20 weight part that falls into oblivion, as: but it is not limited only to 5 weight parts, 7 weight parts, 10 weight parts, 12 weight parts, 15 weight parts, 18 weight parts and 20 weight parts.
The present invention's alleged " borneol " be by composite family Herba Blumeae Balsamiferae stem leaf or canella borneol camphor tree branches and leaves through steam distillation and recrystallization and obtain, also title borneol or 2-thatch alcohol (CAS:507-70-0). Taste is pungent, bitter, micro-cold; The thoughts of returning home, liver, lung channel; Delicate fragrance a surname is loose, has inducing resuscitation of having one's ideas straightened out, and the loose poison of heat-clearing, effect of improving acuity of vision and removing nebula, cures mainly pyreticosis unconsciousness due to high fever, and apoplexy coma due to blocking of the respiratory system shies epilepsy, and summer-heat and damp hoodwinks key clearly, and larynx numbness is deaf, and aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid, conjunctival congestion with pain and swelling of the eye, pterygium. Available its for making medicine, consumption is 5 weight part��20 weight parts, as: but be not limited only to 5 weight parts, 7 weight parts, 10 weight parts, 12 weight parts, 15 weight parts, 18 weight parts and 20 weight parts.
Children are the body of blood-head, and skin is tender and lovely, infect foul gas, invade stain skin and then send out as diaper rash, therefore are main medicine with Asian puccoon heat-clearing, cool blood and removing toxic substances. Again because children liver is often had a surplus, nice sweet food and fragrant dry thing in addition, stagnated heat originated endogenously, hot poison accumulates steaming skin, feels again the heresy of rheumatism, damp and hot Jusheng, rich knot skin and become eczema, therefore select kuh-seng, the coptis, rough gentian and Root-bark of Densefruit Pittany heat-clearing and damp-drying drug, removing toxic substances of dispeling the wind be ministerial drug altogether. Intimately flourishing, heat heap soil or fertilizer over and around the roots muscle is then sent out as furuncle, is necessary purging intense heat of detoxifying, therefore selects cape jasmine, rheum officinale and rhizoma et Radix Baphicacanthis Cusiae to let out its fire poison, and borneol also has swelling and pain relieving and preservative activity, is adjutant altogether. Full side share, and bitter cold is directly rolled over, and fire-evil is gone and heat poison solution, then all disease self-healing.
A kind of composition provided by the invention, is Chinese medicinal materials composition, by weight, comprises
Asian puccoon 30��70, the coptis 30��70, rough gentian 5��40, kuh-seng 5��20, Root-bark of Densefruit Pittany 5��20, rheum officinale 30��70, cape jasmine 5��30, rhizoma et Radix Baphicacanthis Cusiae 5��20 and borneol 5��20.
Another kind of composition provided by the invention, is Chinese medicinal materials composition, by weight, comprises
Asian puccoon 60, rheum officinale 40, the coptis 40, rough gentian 30, kuh-seng 15, cape jasmine 20, rhizoma et Radix Baphicacanthis Cusiae 10, Root-bark of Densefruit Pittany 10 and borneol 10.
Another kind of composition provided by the invention, is Chinese medicinal materials composition, by weight, comprises
Monarch's medicine: Asian puccoon 30��70; With
Ministerial drug: the coptis 30��70, rough gentian 5��40, kuh-seng 5��20, Root-bark of Densefruit Pittany 5��20; With
Adjutant: rheum officinale 30��70, cape jasmine 5��30, rhizoma et Radix Baphicacanthis Cusiae 5��20; And
Make medicine: borneol 5��20.
Various composition provided by the invention, bitter cold is directly rolled over, and makes that fire-evil is gone and heat poison is separated, then all disease self-healing, is suitable for treating the eczema caused by children's (comprising baby, child and children's etc.) blood poison, heat poison, wet poison.
Composition provided by the invention, makes various preparation by the common concocting method of Chinese materia medica, as: but it is not limited only to decoction, powder, paste and patch etc.
For ease of using, prioritizing selection ointment of the present invention, comprises above-mentioned various composition, and sesame oil and beeswax are made as auxiliary material. Its preparation method is as follows:
Except Asian puccoon, the 7 taste medicinal materials such as rheum officinale, the coptis, rough gentian, kuh-seng, cape jasmine, rhizoma et Radix Baphicacanthis Cusiae and Root-bark of Densefruit Pittany, suitably drink in broken section, separately get appropriate sesame oil (as: 880g), to withered with putting frying in pot, remove slag, obtain preliminary working thing; Entering pot after Asian puccoon use water is wetting, frying, to red-purple, removes slag, filters, blended with preliminary working thing, and adds appropriate beeswax (as: 120g), adds borneol powder after thawing, stirs evenly, is down to room temperature and get final product.Before using, lotion is filling, it is stored in shady and cool ventilation place.
Produce sesame oil used and beeswax total amount is 900 grams��1200 grams, sesame oil: beeswax mass ratio is 700��900: 100��400.
The useful effect that technical solution of the present invention realizes:
Various composition provided by the invention, is monarch's medicine taking Asian puccoon, coordinates other several kinds of Chinese medicinal materials and become, having bitter cold directly rolls over, and makes effect that fire-evil is gone and heat poison is separated.
Various composition provided by the invention, specially for the skin that children are tender and lovely, clearing heat and detoxicating, profit is wet antipruritic, gentle non-stimulated, not easily irritated, has no drug resistance, is easy to be accepted by infant and the head of a family.
Various composition provided by the invention; natural plant material is adopted to treat children's eczema as medicine portion evident in efficacy; not containing stimulation component; being conducive to the skin protecting infant tender and lovely, safety is gentle, has no side effect; clear curative effect; easy to use, the prices of raw and semifnished materials are cheap, are suitable for large-scale promotion clinically.
Embodiment
The technical scheme of the present invention is below described in detail. The embodiment of the present invention is only in order to illustrate the technical scheme of the present invention and unrestricted, although with reference to better embodiment to invention has been detailed explanation, it will be understood by those within the art that, the technical scheme of invention can be modified or equivalent replacement, and not departing from the spirit and scope of technical solution of the present invention, it all should be encompassed in the right of the present invention.
Embodiment 1
Except Asian puccoon, put into Rhizoma Coptidis 30��70, rough gentian 5��40, kuh-seng 5��20, Root-bark of Densefruit Pittany 5��20, rheum officinale 30��70, cape jasmine 5��30, rhizoma et Radix Baphicacanthis Cusiae 5��20 by weight, suitably drink in broken section, separately get sesame oil frying to withered, remove slag, obtain preliminary working thing; Entering pot after Asian puccoon use water is wetting, frying, to red-purple, removes slag, filters, blended with preliminary working thing, and adds beeswax, adds borneol powder 5��20 weight part after thawing, stirs evenly, is down to room temperature, filling, is stored in shady and cool ventilation place for subsequent use.
Embodiment 2
The obtained Chinese medicine composition ointment (being named: the clean ointment of youngster's rash) of the present embodiment 1 carries out clinical pre-experiment, and embodiment is as follows:
(1) clinical data
1. case source: all research case histories source is affiliated hospital of Shandong Traditional Chinese Medicine University the 2nd paediatrics outpatient service infant.
2. case selection standard: (1) is based on infant's lactation; (2) position of eczema is mainly with the women's head-ornaments position such as around volume portion eyebrow, two cheeks, scalp, auricle, and shoulder, the back of the body, four limbs are main; (3) the lighter's pachylosis is rubescent, and severe one has the skins such as erythema, papule and bubble to damage, and accompanies swollen pain, sepage and erosion, local itch and tenderness; (4) companion cry and scream, have the fidgets, the symptom such as not good enough of sleeping, severe patient occurs together the constitutional symptoms such as heat.
3. include standard in: (1) makes a definite diagnosis as infantile eczema; (2) infants within two years old; (3) skin plays erythema, papule, bubble, and even erosion is oozed out, and with itch.
4. exclusion standard: (1) more than 2 years old patient; (2) not by regulation medication or add and use other medicine; (3) get rid of and in 1 week, accept glucocorticosteroid and antihistamine drug treatment person; (4) breakage has erosion, oozes out and suppuration person; (5) immunization person during treatment.
5. reject standard: to being selected into this clinical study, belong to the one of following situation, as rejecting case: (1) does not meet the standard of including in, or the person that meets exclusion standard; (2) non-users of medicine; (3) without any keeper.
6. come off (exiting) standard: to being selected into this clinical study, belongs to the one of following situation, as the case that comes off: (1) experimenter's compliance is poor, can not medication according to quantity on time; (2) medicine that other influences tolerance judges is used; (3) experimenter is unwilling to proceed clinical trial, proposes, to physician, the person of exiting.
(2) medicine and methods for the treatment of is studied
1. study medicine:
Test drug: the ointment formulation of the Chinese medicine composition of the present embodiment 1, pack by Yangzijiang Pharmaceutical Group, Shanghai Haini Pharmaceutical Co., Ltd and provide, specification 10g/ box, test medication meets clinical study quality standard (draft) (see " GCP ", State Food and Drug Administration makes No. 3).
2. methods for the treatment of: getting this ointment coating affected part with cotton swab, every day 2��3 times 7 days is a course for the treatment of.
(3) project is observed
1. the relevant performance of infantile eczema: the symptoms such as treatment front and back different times skin erythema, papule, bleb, tenderness;
2. trial period untoward reaction.
(4) some observing time
Observed with the medical same day, medical 3rd day, medical 7th day respectively.
(5) efficacy and safety judgement criteria
1. the standard of curative effect evaluation:
Recovery from illness: skin damages and disappears, and without crying and screaming, sleeps good; Total mark is 0 point;
Effective: skin damages and disappears > 90%, without crying and screaming agitation, sleep obviously improves; Total mark reduces > 50%;
Take a turn for the better: skin damages and do not disappear or increase increase, and agitation of crying and screaming, poor sleep do not improve; Total mark reduces < 30%.
2. safety evaluation standard:
With or without adverse events occurs between trial period.
(6) adverse events record, quality control and ethics requirement
Strictly being undertaken by GCP and relevant laws and regulations, detail is shown in research approach.
(7) data management and analysis
1. investigator must ensure that data are true, complete, accurate;
2. research record all items all need to fill in, must not null term, leakage item; Do any corrigendum can only rule, sidenote change after data, give reasons, and sign by investigator and date, must not obliterating, cover source recording;
3. test case completes observation and the data such as research record is handed in latter 3 days research responsible official's examination & verification, will study case friendship project responsible official in 10 days.
(8) statistical study
Completing by statistician, content comprises: 1. add up the selected quantity of experimenter, come off and reject case situation; 2. statistical study describes with all numbers, standard deviation, percentage; 3. safety analysis.
The obtained Chinese medicine composition ointment of the present embodiment 1 carries out clinical pre-experiment, and experimental result is as follows:
(1) totally 31 example infants include clinical trial in, and wherein 1 example comes off, and complete case 30 example, man 15 example, female 15 example.
(2) observation of curative effect:
1. rapid-action, about 1 day visible curative effect such as erythema, papule, poor sleep, itch can take effect half a day, within about 1.5 days, gets final product complete incidence graph, in table 1 and table 2.
Table 1 youngster examines each symptom onset time [�� S] of clean Ointment in Treatment infantile eczema
Table 2 youngster examines clean Ointment in Treatment infantile eczema itch onset and extinction time [�� S]
2. youngster examines clean Ointment in Treatment 3 days, and all observation cases is all effective in cure, and obvious effective rate 86.7%, always has efficiency 100%, in table 3.
Table 3 youngster examines clean Ointment in Treatment infantile eczema the 3rd day clinical efficacy [example (%)]
3. youngster examined clean Ointment in Treatment after 7 days, cure rate big 80%, and more person's clinical symptom is not obviously alleviated, in table 4.
Table 4 youngster examines clean treatment infantile eczema the 7th day clinical efficacy [example (%)]
(3) safety analysis:
Through clinical observation in 7 days, do not find untoward reaction.
The clinical upper harm mainly of eczema is that skin damages and very itches unbearably, and recurrent exerbation seriously affects children's's physical and mental health. The Chinese medicine ointment (youngster examines clean ointment) that the present embodiment provides has feature rapid-action, evident in efficacy in treatment eczema, the itch of serious puzzlement infant got final product complete incidence graph at about 1 day half, and most case can be improved obviously by general manifestation within one week. Except evident in efficacy, this prescription prescription is entirely Chinese medicine, has characteristic, and none example untoward reaction occurs or increases the weight of situation in experimentation, potential use value can be affirmed, but owing to experimental observation case is less, the time is shorter in pre-experimentation, the validity of medicine, security require further study test and confirm. For the pathological characteristic of infantile eczema recurrent exerbation, the indexs of correlation such as infant recurrence rate should be observed further.
The composition that the present embodiment provides is pure Chinese medicinal preparation, not containing hormone, treatment infantile eczema, furuncle is had obvious clinical effectiveness, and treatment cycle is short, curative ratio height, and without toxic side effect, smell without exception, is easy to be accepted by the patient head of a family. In Clinical observation all observation cases is all effective in cure, do not find untoward reaction. The present invention has clear superiority compared with the paste of traditional treatment eczema.
Claims (13)
1. a composition, is ointment formulation, is characterised in that, by weight, comprises
Asian puccoon 30��70, the coptis 30��70, rough gentian 5��40, kuh-seng 5��20, Root-bark of Densefruit Pittany 5��20, rheum officinale 30��70, cape jasmine 5��30, rhizoma et Radix Baphicacanthis Cusiae 5��20, borneol 5��20, and appropriate sesame oil and appropriate beeswax.
2. a composition, is ointment formulation, is characterised in that, by weight, comprises
Monarch's medicine: Asian puccoon 30��70; With
Ministerial drug: the coptis 30��70, rough gentian 5��40, kuh-seng 5��20, Root-bark of Densefruit Pittany 5��20; With
Adjutant: rheum officinale 30��70, cape jasmine 5��30, rhizoma et Radix Baphicacanthis Cusiae 5��20; With
Make medicine: borneol 5��20, and appropriate sesame oil and appropriate beeswax.
3. composition according to claim 1 and 2, it is characterised in that described Asian puccoon is 60 weight parts.
4. composition according to claim 1 and 2, it is characterised in that described rheum officinale is 40 weight parts.
5. composition according to claim 1 and 2, it is characterised in that the described coptis is 40 weight parts.
6. composition according to claim 1 and 2, it is characterised in that described rough gentian is 30 weight parts.
7. composition according to claim 1 and 2, it is characterised in that described kuh-seng is 15 weight parts.
8. composition according to claim 1 and 2, it is characterised in that described cape jasmine is 20 weight parts.
9. composition according to claim 1 and 2, it is characterised in that described rhizoma et Radix Baphicacanthis Cusiae is 10 weight parts.
10. composition according to claim 1 and 2, it is characterised in that described Root-bark of Densefruit Pittany is 10 weight parts.
11. compositions according to claim 1 and 2, it is characterised in that described borneol is 10 weight parts.
The application of 12. compositions according to claim 1 and 2 in the medicine preparing prevention and therapy children's eczema.
13. compositions according to claim 1 and 2, it is characterised in that described ointment formulation is produced as follows:
Except described Asian puccoon, described rheum officinale, the described coptis, described rough gentian, described kuh-seng, described cape jasmine, described rhizoma et Radix Baphicacanthis Cusiae and described Root-bark of Densefruit Pittany are amounted to 7 taste medicinal materials, suitably drinks in broken section, separately get appropriate sesame oil, to withered with putting frying in pot, remove slag, obtain preliminary working thing;
Entering pot after described Asian puccoon use water is wetting, frying, to red-purple, removes slag, filters, blended with described preliminary working thing, and adds appropriate beeswax, adds borneol powder after thawing, stirs evenly, is down to room temperature and get final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106237030A (en) * | 2016-08-25 | 2016-12-21 | 济南市儿童医院 | A kind of Chinese medicine composition treating infant eczema and preparation method thereof |
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Application publication date: 20160608 |