CN1739638A - Medicine for treating dermatosis and its prepn - Google Patents
Medicine for treating dermatosis and its prepn Download PDFInfo
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- CN1739638A CN1739638A CNA2005100031922A CN200510003192A CN1739638A CN 1739638 A CN1739638 A CN 1739638A CN A2005100031922 A CNA2005100031922 A CN A2005100031922A CN 200510003192 A CN200510003192 A CN 200510003192A CN 1739638 A CN1739638 A CN 1739638A
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Abstract
The medicine for treating dermatosis is prepared with five kinds of Chinese medicinal materials, including paris rhizome, Chinese goldthread, skullcap root, rhubarb and gromwell, and the recipe may have other four kinds of Chinese medicinal materials in certain weight proportion. It may be medicine powder, decoction, ointment or paste. The medicine has the functions of clearing away heat and toxic material, promoting blood circulation to disperse blood clots, eliminating swelling and pain, etc. and may be used in treating acne, bedsore, boil, eczema, dermatitis, burns, scalds and other dermatosis. It has the advantages of high healing effect, fast acting, no irritation to skin, etc.
Description
[technical field]
The present invention relates to dermopathic medicine of a kind of treatment and preparation method thereof, belong to technical field of Chinese medicines.
[background technology]
Dermatosis be one of common disease, especially acne, eczema, decubital ulcer, dermatitis, herpes zoster, burn and scald clinical comparatively common, these sick kinds are in adopting clinically, western medical treatment all obtains curative effect preferably.For a long time, the medical personnel makes every effort to explore a kind of bacillary and medicine viral dermatosis of can treating. the medicine of disclosed treatment various skin disease in patent documentation, in CN1621074A application part, the dermopathic medicine of treatment is described as Hu Xiangren, can treat dermatitis, decubital ulcer, burn and scald, only limit to treat bacterial dermatosis, do not relate to the treatment of viral dermatosis, as herpes zoster, herpes simplex.Clinically and the patient still have demand to can effectively treating bacillary and medicine viral dermatosis.Up to now, also do not find the identical report of relevant pharmaceutical composition of the present invention.
[summary of the invention]
The object of the invention is to provide a kind of and can effectively treats bacillary and medicine viral dermatosis.
Another object of the present invention has provided the preparation method of this medicine.
Medicament selection Rhizoma Paridis of the present invention, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) make up, and wherein select for use Rhizoma Paridis to be because Rhizoma Paridis nature and flavor bitter cold has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cooling blood, expelling wind can be separated the carbuncle poison, can treat skin infection again, the ulcer sores heat in blood is caused the patient should be used.Selecting Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) for use, is because of Rhizoma Coptidis nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication, treat sore, modern pharmacological research confirms that Rhizoma Coptidis has antibiotic, antifungal, antivirus action has stronger inhibitory action to 7 kinds of gram negative bacterias and 5 kinds of gram positive bacterias.Radix Scutellariae, the nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication is treated carbuncle sore tumefacting virus.Modern pharmacological research confirms, that Radix Scutellariae has is antibiotic, antifungal, antiviral, antiinflammatory, antiallergic action.Radix Et Rhizoma Rhei, the nature and flavor bitter cold, clearing away heat-fire, promoting blood circulation and detoxication, eliminating blood stasis and inducing menstruation is treated the carbuncle furuncle, has clearing away heat-fire, and blood circulation promoting and blood stasis dispelling dual function, Radix Et Rhizoma Rhei are purgatives medicine (expelling the heat-evil), and the following clearly and usefulness of the product of compatibility clearing away heat-fire (Rhizoma Coptidis, Radix Scutellariae) is to strengthen the effect of heat clearing away.Radix Arnebiae (Radix Lithospermi), the nature and flavor bitter cold, removing heat from blood and promoting blood circulation, heat-clearing and toxic substances removing, rash is used for the heat in blood poison and contains, and macule is not saturating, the carbuncle skin infection.This four Chinese medicine heat-clearing and toxic substances removing, purging fire and cooling blood, promoting blood circulation to remove blood stasis helps the effect of Rhizoma Paridis altogether.
In order to reach better therapeutic, medicine of the present invention also with Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae combination, select Rhizoma Polygoni Cuspidati, the property mildly bitter flavor, be slightly cold, expelling wind and removing dampness, the dissipating blood stasis analgesic therapy is used for carbuncle sore tumefacting virus, burn and scald.Modern pharmacological research confirms that Rhizoma Polygoni Cuspidati has antibiotic, antiviral and antipyretic effect.Fructus Gardeniae, the nature and flavor bitter cold has heat-clearing and toxic substances removing, and the merit of purging fire and cooling blood is used for pathogenic fire,toxin and furuncles, and the pain of injury swells and ache.Cortex Phellodendri, the nature and flavor bitter cold, heat clearing and damp drying, pathogenic fire purging removes steams, and skin ulcer is treated in detoxifcation.Be used for sore swollen toxin, the eczema pruritus.Modern pharmacological research confirms that Cortex Phellodendri has antibiotic antiulcer action.Caulis Sargentodoxae, nature and flavor are bitter flat, and heat-clearing and toxic substances removing is arranged, and the merit of promoting blood circulation to remove blood stasis pain relieving is used for pathopyretic ulcer.Above four Chinese medicine helps the monarch and his subjects' product heat-clearing and toxic substances removing, purging fire and cooling blood, the merit of promoting blood circulation to remove blood stasis altogether.
The consumption of drug component of the present invention is to sum up through a large amount of clinical the groping of inventor, wherein comprises Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) 5 flavor medicines at least, and the crude drug effective dose has better curative effect in the following weight parts scope:
Rhizoma Paridis 10-30 part, Rhizoma Coptidis 8-16 part, Radix Scutellariae 8-16 part, Radix Et Rhizoma Rhei 8-16 part, Radix Arnebiae (Radix Lithospermi) 5-10 part.
Be preferably: 15 parts of Rhizoma Paridis, 10 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariaes, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Arnebiae (Radix Lithospermi)s.
For improving curative effect, can also add Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae 4 flavor medicines.
Medicine material survival dose of the present invention can also be: Rhizoma Paridis 10-30 part, Rhizoma Coptidis 8-16 part, Radix Scutellariae 8-16 part, Radix Et Rhizoma Rhei 8-16 part, Radix Arnebiae (Radix Lithospermi) 5-10 part, Rhizoma Polygoni Cuspidati 10-30 part, Fructus Gardeniae 8-16 part, Cortex Phellodendri 8-16 part, Caulis Sargentodoxae 8-16 part.
Be preferably: 15 parts of Rhizoma Paridis, 10 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariaes, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Polygoni Cuspidati, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Phellodendris, 10 parts of Caulis Sargentodoxaes.
Medicine of the present invention adopts the preparation method of Chinese medicine preparation to make any conventional external preparation, the unmixed unguentum, water preparation, oil preparation, paste, powder evenly made of for example these crude drug can being pulverized uses, but in order to make these crude drug bring into play its drug effect better, the preparation method of preferred active constituent of the present invention is as follows:
A) take by weighing each crude drug Rhizoma Paridis according to weight proportion, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) are standby;
B) above-mentioned Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) water are decocted 2 times, each 1.5 hours, merge decoction liquor twice, be condensed into thick paste after the filtration, dry under 45-50 ℃ of temperature, make dry extract I;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract II;
D) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
If also with Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae combination, its preparation method is:
A) it is standby to take by weighing each crude drug Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae according to the weight proportion of prescription;
B) above-mentioned Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae water are decocted 2 times, each 1.5 hours, merge decoction liquor twice, make dry extract III;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract IV;
D) merge dry extract III and IV, it is ground into powder, just make the active constituent of medicine of the present invention.
The active constituent of medicine of the present invention can add various adjuvants required when putting into the different exterior-applied formulation of preparation, be prepared into any exterior-applied formulation commonly used as vaseline, lanoline, Oleum Sesami, vegetable oil, liquid paraffin, aquae destillata, glycerol etc. with the Chinese medicine preparation of routine, as powder, water preparation, unguentum, paste, Emulsion.
Medicine of the present invention has heat-clearing and toxic substances removing, purging fire and cooling blood, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, and putrefaction-removing granulation-promoting, the function of antiphlogistic antibacterial, antiviral is used for the treatment of acne, decubital ulcer, furuncle, eczema, dermatitis, herpes zoster, simple property kitchen rash and burn and scald.
[specific embodiment]
Further specify the beneficial effect of medicine of the present invention below by clinical trial statistics and model case.
Drug invention people of the present invention since nineteen ninety-eight, is used for the treatment of acne, decubital ulcer, eczema, dermatitis, furuncle, herpes zoster, herpes simplex from making " golden holy skin infection heal cream ", and sick and wounded 272 examples of burn and scald, and treatment situation statistics is as follows:
Various case statistical tables
| The sick kind | Case load | Consumption | Treatment time | Effective percentage | Cure rate | Remarks |
| Acne | 32 | 3 times/day | 7-20 days | 100％ | 96％ | No cicatrix |
| Decubital ulcer | 35 | 4 times. day | 10-15 days | 100％ | 94％ | |
| Furuncle | 30 | 1-2 time/day | 3-7 days | 100％ | 97％ | |
| Eczema | 45 | 3-4 time/day | 3-7 days | 100％ | 96％ | |
| Dermatitis | 42 | 3-4 time/day | 5-10 days | 100％ | 100％ | |
| Herpes zoster | 28 | 3-4 time/day | 7-20 days | 100％ | 96％ | |
| Herpes simplex | 25 | 3-4 time/day | 5-10 days | 100％ | 100％ | |
| Burn and scald | 35 | 3-4 time/day | 3-20 days | 100％ | 97％ | No cicatrix |
Model case:
Liu Chaoxian, the man 80 years old, lives in Guiyang Luo Wandabaocun.Be unable to leave the bed after suffering from cerebral hemorrhage, decubital ulcer appears in buttocks after half a year, and skin ulcer face 1.5 * 1.5cm 3 places use this medicine after 10 days, recovery from illness.
Ju Jianying, the woman, 35 years old, live in the Guiyang telephone number: 13985550153, face, forehead skin is uneven, red itching, pore is coarse, is diagnosed as acne, uses this medicine after 20 days, and skin is not smooth, and is red, do not itch, and skin pore obviously dwindles, not recurrence in 7 years.
Sun Mengdie, the woman, 46 years old, the popular company limited quality inspection of the Guizhou rubber worker of section suffered from herpes zoster in 2000, spread all over shirtfront and back, and pain is prepared hospitalization unbearably.After using this medicine, recovery from illness on the 20th is not in hospital.
Zhou Jiaping, woman, 43 years old, cloud hotel worker is stood in Kweiyang, and the junior two in the first month of the lunar year, 2002 is overflowed thick gravy by pressure cooker entire face is scalded, and is facial red and swollen, blister is abound with, and binocular can not be opened, and mouth can not open, being diagnosed as the II level scalds, use golden holy skin infection to heal behind the cream 1 hour, binocular can be opened, and can speak, after 10 days, it is as excellent as before that entire face is recovered.
Feng Linghan, the woman, 1 years old half, live No. 10 two unit, all sorts of flowers hill path, Guiyang, sat cross-legged in meditation accidentally on quartzy stove winter in 1999, buttocks and pudendum burn are diagnosed as II level burn, use this medicine after, pain alleviates immediately, 10 days and heal no cicatrix.
Use during the medicine of the present invention diet suffering, peppery, fish, seafood, bean product; Cloudy disease person forbidding.
[embodiment]
Come further to set forth preparation method of the present invention by the following examples;
Embodiment 1: the water preparation preparation of medicine of the present invention
A) take by weighing Rhizoma Paridis 15g, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, each 10g of Caulis Sargentodoxae, Radix Arnebiae (Radix Lithospermi) 5g decocts with water 2 times, and each 1.5 hours, merge decocting liquid twice, be condensed into thick paste after the filtration, dry under 45-50 ℃, make dry extract I;
B) will decoct the back medicinal residues and carry out reflux, extract, 2 times with ethanol, each 2 hours, merge extracted twice liquid, filter, reclaim ethanol and be condensed into thick paste, dry under 45-50 ℃, make dry extract II;
C) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
D) the pharmaceutically active component with said extracted adds aquae destillata by 1: 200 weight ratio, adds 10% glycerol again, makes water preparation.
Embodiment 2: the unguentum preparation of medicine of the present invention
A) take by weighing Rhizoma Paridis 15g, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, each 10g of Caulis Sargentodoxae, Radix Arnebiae (Radix Lithospermi) 5g decocts with water 2 times, and each 1.5 hours, be condensed into thick paste after the filtration, dry under 45-50 ℃, make dry extract I;
B) will decoct the back medicinal residues and carry out reflux, extract, 2 times with ethanol, each 2 hours, merge extracted twice liquid, filter, reclaim ethanol and be condensed into thick paste, dry under 45-50 ℃, make dry extract II;
C) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
D) the pharmaceutically active component of said extracted is added vaseline 200g, lanoline 20g, behind the mix homogeneously, make unguentum, be inventor's homemade " golden holy skin infection heal cream ".
Embodiment 3: the paste preparation of medicine of the present invention
A) take by weighing Rhizoma Paridis 15g, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, each 10g of Caulis Sargentodoxae, Radix Arnebiae (Radix Lithospermi) 5g decocts with water 2 times, and each 1.5 hours, merge decocting liquid twice, be condensed into thick paste after the filtration, dry under 45-50 ℃, make dry extract I;
B) will decoct the back medicinal residues and carry out reflux, extract, 2 times with ethanol, each 2 hours, merge extracted twice liquid, filter, reclaim ethanol and be condensed into thick paste, dry under 45-50 ℃, make dry extract II;
C) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
D) the pharmaceutically active component with said extracted adds vaseline 200g, glycerol 20g, Pulvis Talci 50g, makes paste behind the mix homogeneously.
Claims (7)
1 one kinds of dermopathic medicines of treatment is characterized in that this medicine comprises Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) 5 flavor medicines at least, and each crude drug effective dose is in the following weight parts scope:
Rhizoma Paridis 10-30 part, Rhizoma Coptidis 8-16 part, Radix Scutellariae 8-16 part, Radix Et Rhizoma Rhei 8-16 part, Radix Arnebiae (Radix Lithospermi) 5-10 part.
2 medicines according to claim 1 is characterized in that the weight portion of above-mentioned raw materials medicine is:
15 parts of Rhizoma Paridis, 10 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariaes, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Arnebiae (Radix Lithospermi)s.
3 preparation methoies according to claim 1 or 2 medicines is characterized in that this method comprises the following steps:
A) take by weighing each crude drug Rhizoma Paridis according to weight proportion, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) are standby;
B) above-mentioned Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi) water are decocted 2 times, each 1.5 hours, merge decoction liquor twice, be condensed into thick paste after the filtration, dry under 45-50 ℃ of temperature, make dry extract I;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract II;
D) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention.
4 medicines according to claim 1, it is characterized in that can also adding in the above-mentioned raw materials medicine Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae 4 flavor medicines, each raw material medicines in portions by weight is: Rhizoma Paridis 10-30 part, Rhizoma Coptidis 8-16 part, Radix Scutellariae 8-16 part, Radix Et Rhizoma Rhei 8-16 part, Radix Arnebiae (Radix Lithospermi) 5-10 part, Rhizoma Polygoni Cuspidati 10-30 part, Fructus Gardeniae 8-16 part, Cortex Phellodendri 8-16 part, Caulis Sargentodoxae 8-16 part.
5 medicines according to claim 1 is characterized in that each raw material medicines in portions by weight is: 15 parts of Rhizoma Paridis, 10 parts of Rhizoma Coptidis, 10 parts of Radix Scutellariaes, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Polygoni Cuspidati, 10 parts of Fructus Gardeniaes, 10 parts of Cortex Phellodendris, 10 parts of Caulis Sargentodoxaes.
6 preparation methoies according to claim 4 or 5 medicines is characterized in that this method comprises the following steps:
A) it is standby to take by weighing each crude drug Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae according to the weight proportion of prescription;
B) above-mentioned Rhizoma Paridis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi), Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae water are decocted 2 times, each 1.5 hours, merge decoction liquor twice, make dry extract III;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract IV;
D) merge dry extract III and IV, it is ground into powder, just make the active constituent of medicine of the present invention.
The preparation method of 7 medicines according to claim 1 is characterized in that this medicine can be made into externally-applied powder, water preparation, unguentum, paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100031922A CN100360160C (en) | 2005-08-31 | 2005-08-31 | Medicine for treating dermatosis and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100031922A CN100360160C (en) | 2005-08-31 | 2005-08-31 | Medicine for treating dermatosis and its prepn |
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| Publication Number | Publication Date |
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| CN1739638A true CN1739638A (en) | 2006-03-01 |
| CN100360160C CN100360160C (en) | 2008-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100031922A Expired - Fee Related CN100360160C (en) | 2005-08-31 | 2005-08-31 | Medicine for treating dermatosis and its prepn |
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| CN101584773B (en) * | 2009-06-10 | 2011-05-11 | 张学贵 | Chinese herbal medicament for treating skin diseases |
| CN101732462B (en) * | 2009-11-11 | 2012-01-11 | 宋爱民 | Chinese medicinal preparation for treating herpes zoster |
| CN102028793A (en) * | 2010-11-19 | 2011-04-27 | 黄文扬 | Traditional Chinese medicinal composition for treating burns and scalding |
| CN102028793B (en) * | 2010-11-19 | 2012-01-04 | 黄文扬 | Traditional Chinese medicinal composition for treating burns and scalding |
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| CN104940369A (en) * | 2015-07-03 | 2015-09-30 | 赵德欣 | External use traditional Chinese medicine composition for treating herpes zoster and preparation method thereof |
| CN105902710A (en) * | 2016-05-11 | 2016-08-31 | 林朝辉 | Traditional Chinese medicine for treating herpes zoster |
| CN110051738A (en) * | 2019-04-30 | 2019-07-26 | 叶柳兴 | It is a kind of specially to control burn and scald specific prescription |
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| CN100360160C (en) | 2008-01-09 |
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