CN104055925A - Traditional Chinese medicine composition for treating diabetic peripheral neuropathy - Google Patents
Traditional Chinese medicine composition for treating diabetic peripheral neuropathy Download PDFInfo
- Publication number
- CN104055925A CN104055925A CN201310084469.3A CN201310084469A CN104055925A CN 104055925 A CN104055925 A CN 104055925A CN 201310084469 A CN201310084469 A CN 201310084469A CN 104055925 A CN104055925 A CN 104055925A
- Authority
- CN
- China
- Prior art keywords
- radix
- chinese medicine
- medicine composition
- peripheral neuropathy
- diabetic peripheral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, which is prepared from radix astragali, medlar, radix paeoniae rubrathe, loranthus parasiticus, salvia, rehmanniae radix, lumbricus, achyranthes roots, corydalis tuber, and the like according to a certain weight ratio. According to the dosage form requirement for drugs to be prepared, the composition can be prepared into capsules, tablets, granules, powder, oral liquid and pills. The traditional Chinese medicine composition of the invention has the effects of invigorating spleen and nourishing kidney, invigorating blood circulation and relaxing vein, and has good effect on preventing and treating diabetic peripheral neuropathy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition for the treatment of diabetic peripheral neuropathy.
Background technology
Diabetes are a kind of common incretion metabolism diseases, along with socioeconomic development, the raising of people's living standard, the change of aged tendency of population and life style, the sickness rate of diabetes is ascendant trend year by year in the world, has become the 3rd disease that threatens human health and life after cardiovascular and tumor.Diabetic peripheral neuropathy is the multiple Peripheral nerve diseases of diabetes, is diabetes serious and the most common chronic complicating diseases and the one of the main reasons disabling.Prolongation along with diabetic duration, there is diabetic peripheral neuropathy in various degree in about 90% above patient, general type i diabetes patient can be worsened rapidly in morbidity Hou2-3Nian Nei function of nervous system, usually when making a definite diagnosis, just there is the nerve conduction velocity phenomenon that slows down in type ii diabetes patient, have at least 25% diabetics within 25 years, serious diabetic peripheral neuropathy can occur after making a definite diagnosis, in all non-traumatic low level amputations, diabetics accounts for 40-60%, and protracted inflammation is difficult, disability rate and case fatality rate are high, treatment difficulty.Its clinical characters is: onset concealment, make slow progress, and show as sensory disturbance.Clinical visible symmetry numb limbs and tense tendons, pain, sensation difference, burn feeling, hyperesthesia, is glove sample sensation, and the later stage can show as to be felt to go down, disappear, and diabetic foot occurs, and to diabetics, brings very large misery, has a strong impact on its quality of life.
The pathogenesis of diabetic peripheral neuropathy is illustrated not yet completely, and the symptom of diabetic peripheral neuropathy is usually difficult to process clinically, there is no the Therapeutic Method of specially good effect at present both at home and abroad.Western medical treatment diabetic peripheral neuropathy, except controlling blood glucose, adopts vitamin B group, vasodilation, analgesic and antioxidation more, supplements the symptomatic treatments such as neurotrophic factor, is difficult to reach satisfactory effect.Although the new drug of research is many, or because side effect affects its clinical use value, or because of the single unsatisfactory curative effect of site of action link, or need do further evaluation because of animals and human beings body difference on effect.How utilizing the process of the advantage intervention diabetes of Chinese medicine, delay and treat in time the appearance of diabetic peripheral neuropathy and other complication, is a Scientific And Technical Problems in the urgent need to address.Modern study shows, Chinese medicine is considered to prevent and treat generation and the development of its chronic complicating diseases to the therapeutical effect of type ii diabetes, but not faint (single) blood sugar lowering, the mechanism of action that is Chinese medicine is the integrality of improving patient, its integrated control effectiveness is multipath, too many levels, multifactorial, can promote beta Cell of islet excreting insulin, have again pancreas to act on outward.Therefore, the advantage of performance Chinese medicine in treatment of chronic diseases, the reliable diabetic peripheral neuropathy treatment by Chinese herbs of research clinical efficacy medicine has very important practical significance.
According to diabetic peripheral neuropathy clinical characters and traditional Chinese medical science disease feature, diabetic peripheral neuropathy is attributable to that the traditional Chinese medical science " is quenched one's thirst " and " BI-syndrome involved the blood vessels " the two accompanied symptoms category.The five internal organs are all weak is the basic endogenous cause of ill of diabetes morbidity, slightly reason and meat is not hard and vim and vigour are the basis of the BI-syndrome involved the blood vessels development change of disease of quenching one's thirst all less.Diabetes, under the effect of some specific factors, just can form different complication.For example diabetes fails effectively to control, and consumption impairment of QI is cloudy, symptoms such as occurring polyorexia, polydipsia, polyuria, become thin, be weak.With the passing of time injure spleen kidney, form the gesture of asthenia of both the spleen and kidney.Spleen governing limbs muscle, transfers water paddy elite nutrition skin space between skin and muscles, insufficiency of the spleen failure of skin and muscle to be nourished, numbness of the skin, the sense of ant row; Kidney governing bones, the muscles and bones mistake of suffering from a deficiency of the kidney is supported, and pivot is rolled over sincere shank flaccidity contracture and unable to stand steadily on the ground.Quench one's thirst with the passing of time, the bright cloudy wound of heat, sluggishness or stagnation of blood circulation, sering impatency, stagnation of QI and blood may bring about pain, limbs pain can't bear.In a word, in the developing of primary disease, impairment of both QI and YIN, asthenia of both the spleen and kidney are this, sluggishness or stagnation of blood circulation, and the resistance of sering numbness is for mark, according to Traditional Chinese Medicine rule for the treatment of method for the treatment of, when with tonifying speen and tonifying kidney, the method for promoting blood circulation to remove obstruction in the collateral.
Summary of the invention
The object of this invention is to provide a kind of pathogenic characteristic for diabetic peripheral neuropathy, there is the Chinese medicine composition of tonifying speen and tonifying kidney, promoting blood circulation to remove obstruction in the collateral effect, be mainly used in treating type ii diabetes peripheral neuropathy.
Technical scheme of the present invention is achieved in that
A kind of Chinese medicine composition for the treatment of diabetic peripheral neuropathy, it is characterized in that this Chinese medicine composition is to be made by the raw material of following weight parts: Radix Astragali 25-35, Fructus Lycii 10-20, Radix Paeoniae Rubra 10-20, Herba Taxilli 15-25, Radix Salviae Miltiorrhizae 15-25, Radix Rehmanniae 5-15, Pheretima 5-15, Radix Achyranthis Bidentatae 5-15, Rhizoma Corydalis 5-15.
Preferably, this Chinese medicine composition is to be made by the raw material of following weight parts: Radix Astragali 28-32, Fructus Lycii 13-17, Radix Paeoniae Rubra 13-17, Herba Taxilli 18-22, Radix Salviae Miltiorrhizae 18-22, Radix Rehmanniae 8-12, Pheretima 8-12, Radix Achyranthis Bidentatae 8-12, Rhizoma Corydalis 8-12.
This Chinese medicine composition is to be made by the raw material of following weight parts: the Radix Astragali 30, Fructus Lycii 15, Radix Paeoniae Rubra 15, Herba Taxilli 20, Radix Salviae Miltiorrhizae 20, the Radix Rehmanniae 10, Pheretima 10, Radix Achyranthis Bidentatae 10, Rhizoma Corydalis 10.
A kind of Chinese medicine composition for the treatment of diabetic peripheral neuropathy, the preparation method of its medicine can be routinely extraction and preparation process, for example, the green booth < of model < pharmaceutics of Chinese drugs > > (Shanghai science tech publishing house, within 1997, December is the 1st edition) preparation technology that records, make the acceptable any conventional dosage form of galenic pharmacy, such as capsule, tablet, granule, powder, oral liquid, pill etc.
Treat a Chinese medicine composition for diabetic peripheral neuropathy, on material combination, with the method for tonifying speen and tonifying kidney, promoting blood circulation to remove obstruction in the collateral, applied Radix Astragali tonifying Qi and lifting yang and only disappeared, the gas that Li Ying defends is promoted blood circulation and is monarch drug.For primary disease, quench one's thirst with the passing of time, the bright cloudy wound of heat, the state of affairs of sering numbness resistance, is aided with Fructus Lycii principal drug assistance the kidney invigorating and essence nourishing, and nourishing kidney only disappears; Radix Rehmanniae phencyclidine is only quenched one's thirst, and middle arthralgia due to stagnation of blood cures the wound again; Radix Salviae Miltiorrhizae is invigorated blood circulation and is exempted from numbness, and regulating menstruation is along arteries and veins, and three is ministerial drug altogether.Radix Paeoniae Rubra promoting blood circulation to restore menstrual flow, Pheretima dredging collateral is exempted from numbness; Rhizoma Corydalis promoting blood circulation and stopping pain helps monarch-minister drug promoting blood circulation to restore menstrual flow altogether, exempts from the numbness of promoting blood circulation, and is adjuvant drug.Radix Achyranthis Bidentatae helps monarch-minister drug eliminating blood stasis and inducing menstruation, exempts from the numbness of promoting blood circulation, and draws again all medicines descending, and through sick institute makes medicine as tying-in.All medicines share, concurrence tonifying speen and tonifying kidney, promoting blood circulation to remove obstruction in the collateral, the merit of stasis-dispelling and pain-killing.Make temper rehabilitation, skin must be supported numbness of the skin, the sense of ant row and be disappeared; Kidney essense is abundant, and muscles and bones must be supported and be enjoyed excellent health, and row is vertical freely; Unobstructed vessel, the BI-syndrome involved the blood vessels all pains that must heal all disappear.In theory and practice, all confirm feasible, card medicine be harmonious, can obviously improve diabetic peripheral neuropathy.
The feature of Chinese medicine composition of the present invention is that to select natural plant be raw material, and prescription meets Traditional Chinese medical theory, and pure drug matching is nontoxic to human body.Experimentation and clinical observation show, the extremity sensory disturbance numbness of diabetes, pain etc. are had to good therapeutic effect.And cost of material is cheap, technique preparation is simple, is suitable for industrialization promotion.The capsule making by the present invention, tablet, granule, powder, oral liquid, pill etc. had both kept some characteristics of decoction, have again carry, taking convenience, stable in properties, the advantage such as not perishable, patient is easy to accept.
The specific embodiment
Embodiment 1: a kind of Chinese medicine composition for the treatment of diabetic peripheral neuropathy, is characterized in that this Chinese medicine composition is to be made by the raw material of following weight parts: the Radix Astragali 30, Fructus Lycii 15, Radix Paeoniae Rubra 15, Herba Taxilli 20, Radix Salviae Miltiorrhizae 20, the Radix Rehmanniae 10, Pheretima 10, Radix Achyranthis Bidentatae 10, Rhizoma Corydalis 10.The preparation method of medicine is: above-mentioned raw material of Chinese medicine is fed intake by proportional quantity, add 8 times of water, boil and carry twice, each 1.5 hours, medicinal liquid is concentrated into relative density approximately 1.10, adds ethanol to concentration and is 50%, standing, filter, reclaim ethanol, be concentrated into relative density approximately 1.28, vacuum drying, pulverize, make preparation.
Above-mentioned Chinese medicine composition can also be routinely extraction and preparation process, make the acceptable any conventional dosage form of galenic pharmacy, such as capsule, tablet, granule, powder, oral liquid, pill etc.
For illustrating the therapeutical effect of Chinese medicine composition of the present invention to diabetic peripheral neuropathy, with the granule making by above-described embodiment 1 method " imperial stilbene quench one's thirst TONGMAI KELI ", carried out following pharmacodynamics test and preliminary clinical therapeutic efficacy observes to prove its curative effect, but it can not form any restriction to scope of the present invention.
Results of pharmacodynamic test:
1, the impact on the STZ diabetes rat mechanical stimulus threshold of pain and the electricity irritation threshold of pain: imperial stilbene is quenched one's thirst, and each dosage group of TONGMAI KELI reduces for the STZ diabetes rat mechanical stimulus threshold of pain and the rising of electricity irritation pain threshold, and tool improves significantly.
2, the impact on STZ diabetic sciatic nerve conduction velocity: imperial stilbene each dosage group of TONGMAI KELI of quenching one's thirst can suppress slowing down of STZ diabetic sciatic nerve conduction velocity, and function of peripheral nerves is improved significantly.
3, STZ diabetic mice heat, cold stimulation response time, chemical stimulation pain reactions change and heavy burden are climbed the impact of net time: imperial stilbene each dosage group of TONGMAI KELI of quenching one's thirst can obviously be improved STZ diabetic mice model heat, cold stimulation are reacted bitterly, obviously strengthen muscular strength and the endurance of STZ mice, make to climb net time lengthening, but chemical stimulation is bitterly reacted and had no significant effect.
Clinical therapeutic efficacy:
Criterion of therapeutical effect: carry out curative effect judgement according to < < disease of tcm Standardization of diagnosis and curative effect > >.Effective: subjective symptoms disappears; Effective: subjective symptoms is obviously improved, numbness or pain dimensions reduce, degree lowers; Invalid: symptom is without improvement, numbness or pain dimensions reduce and degree without improvement.
Therapeutic Method: controlling on the basis of blood glucose, giving the imperial stilbene TONGMAI KELI of quenching one's thirst, every day 3 times, each 1 bag (10g), 1 month was 1 course for the treatment of.
Therapeutic effect: by diabetic neuropathy patient 34 examples of Drug therapy asthenia of both the spleen and kidney of the present invention, venation block, treat 1 course for the treatment of (4 weeks), effective 7 examples (20.58%) wherein, effective 21 examples (61.76%), invalid 6 examples (17.64%), total effective rate 82.35%.After treatment, the Follow-up results in 1～February shows, its stable curative effect.
Claims (4)
1. a Chinese medicine composition for the treatment of diabetic peripheral neuropathy, it is characterized in that this Chinese medicine composition is to be made by the raw material of following weight parts: Radix Astragali 25-35, Fructus Lycii 10-20, Radix Paeoniae Rubra 10-20, Herba Taxilli 15-25, Radix Salviae Miltiorrhizae 15-25, Radix Rehmanniae 5-15, Pheretima 5-15, Radix Achyranthis Bidentatae 5-15, Rhizoma Corydalis 5-15.
2. application as claimed in claim 1, is characterized in that this Chinese medicine composition is to be made by the raw material of following weight parts: Radix Astragali 28-32, Fructus Lycii 13-17, Radix Paeoniae Rubra 13-17, Herba Taxilli 18-22, Radix Salviae Miltiorrhizae 18-22, Radix Rehmanniae 8-12, Pheretima 8-12, Radix Achyranthis Bidentatae 8-12, Rhizoma Corydalis 8-12.
3. application as claimed in claim 1, is characterized in that this Chinese medicine composition is to be made by the raw material of following weight parts: the Radix Astragali 30, Fructus Lycii 15, Radix Paeoniae Rubra 15, Herba Taxilli 20, Radix Salviae Miltiorrhizae 20, the Radix Rehmanniae 10, Pheretima 10, Radix Achyranthis Bidentatae 10, Rhizoma Corydalis 10.
4. the application as described in any one in claim 1-3, the pharmaceutical preparation that it is characterized in that this Chinese medicine composition is capsule, tablet, granule, powder, oral liquid or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310084469.3A CN104055925A (en) | 2013-03-18 | 2013-03-18 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310084469.3A CN104055925A (en) | 2013-03-18 | 2013-03-18 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104055925A true CN104055925A (en) | 2014-09-24 |
Family
ID=51544044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310084469.3A Pending CN104055925A (en) | 2013-03-18 | 2013-03-18 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104055925A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728871A (en) * | 2016-12-29 | 2017-05-31 | 安徽中医药大学 | A kind of Chinese medicine preparation for treating diabete peripheral herve pathology |
| CN113082115A (en) * | 2021-04-16 | 2021-07-09 | 辽宁中医药大学 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof |
-
2013
- 2013-03-18 CN CN201310084469.3A patent/CN104055925A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728871A (en) * | 2016-12-29 | 2017-05-31 | 安徽中医药大学 | A kind of Chinese medicine preparation for treating diabete peripheral herve pathology |
| CN113082115A (en) * | 2021-04-16 | 2021-07-09 | 辽宁中医药大学 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101032580B (en) | Medicine for treating rheumatic diseases | |
| KR20240102982A (en) | Traditional Chinese herbal medicine for the treatment of hives, eczema, allergies/kinetic reactive constitution | |
| CN102631579B (en) | Oral Chinese herbal preparation for treating post-traumatic brain syndrome | |
| CN101744970B (en) | Medicine used for type 2 diabetes and preparation method thereof | |
| CN101474361B (en) | Chinese medicine for treating cerebropathy | |
| CN102526677A (en) | Chinese medicine foot-massage composition for treating common cold due to wind-cold | |
| CN101711853B (en) | Traditional Chinese medicine composition for treating symptoms of bradycardia and preparation method thereof | |
| CN103479969B (en) | A kind of medicine for the treatment of manic-depressive psychosis and preparation method thereof | |
| CN117599125A (en) | A Chinese medicinal composition for supplementing calcium and strengthening bones for treating osteoporosis, and its preparation method and application | |
| CN104055925A (en) | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy | |
| CN103495108B (en) | Medicine for treating chronic hypotension and preparation method for medicine | |
| CN103041156B (en) | Drug for treating elderly intractable insomnia and preparation method of drug | |
| CN102552841B (en) | Traditional Chinese medicine for treating apoplexy sequelae | |
| CN110339323A (en) | A kind of Chinese medicine composition and its preparation method and application for treating bradycardia | |
| CN106110218B (en) | A kind of anti-cancer pain pain relieving plaster and preparation method thereof | |
| CN1824075B (en) | Medicinal composition for treating hemicrania and its application | |
| CN105641133A (en) | Composition for prevention and treatment of children eczema and preparation method thereof | |
| CN101983712A (en) | Novel medicament for treating coronary heart disease | |
| CN103349709B (en) | Traditional Chinese medicine preparation capable of tonifying qi and yin and nourishing liver and kidney | |
| CN102406924B (en) | Medicine composition for treating cerebrovascular and cardiovascular diseases as well as preparation method and application thereof | |
| CN111773292B (en) | Traditional Chinese medicine composition for treating herpes zoster as well as preparation method and application thereof | |
| CN102335304B (en) | Chinese medicine composition for dispelling wind, removing dampness, invigorating blood circulation, and relieving pain and preparation method thereof | |
| CN100406035C (en) | Chinese medicine preparation for treating protrasion of lumbar intervertebral disc | |
| CN105832885A (en) | Traditional Chinese medicine composition for treating insomnia | |
| CN1246358A (en) | Medical capsule for treating cerebroma and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DD01 | Delivery of document by public notice |
Addressee: Guangzhou You Haofu Pharmaceutical Technology Co., Ltd Document name: Notification of Passing Preliminary Examination of the Application for Invention |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Guangzhou You Haofu Pharmaceutical Technology Co., Ltd Document name: Notification of before Expiration of Request of Examination as to Substance |
|
| DD01 | Delivery of document by public notice |
Addressee: Guangzhou You Haofu Pharmaceutical Technology Co., Ltd Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140924 |