CN104888056B - A kind of externally applied anti-inflammation, care composition product and preparation technology thereof - Google Patents
A kind of externally applied anti-inflammation, care composition product and preparation technology thereof Download PDFInfo
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- CN104888056B CN104888056B CN201510345606.3A CN201510345606A CN104888056B CN 104888056 B CN104888056 B CN 104888056B CN 201510345606 A CN201510345606 A CN 201510345606A CN 104888056 B CN104888056 B CN 104888056B
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Abstract
The invention provides a kind of can long acting antibiotic, adapt to symptom extensively, externally applied anti-inflammation care composition that good effect, short treating period, abnormal smells from the patient are light and preparation method thereof.The antiinflammatory of externally applied anti-inflammation, care composition, it is characterised in that be made up of the raw material of following weight portion: Cortex Phellodendri 10 20, Radix Angelicae Sinensis 5 15, Fructus Cnidii 5 15, the Fructus Kochiae 3 10, Radix Sophorae Flavescentis 3 10, Rhizoma Acori Graminei 5 15, white Flos Impatientis 5 15, prosperous art 7 20, Folium sophorae 5 15, Fructus Xanthii 3 10, Alumen 3 10, Flos Lonicerae 3 10, Rhizoma Smilacis Glabrae 5 15.This antiinflammatory, care composition use pure Chinese medicinal preparation, scientific compatibility, can be in the case of without Western medicine sterilizing and hormonal components, reach to sterilize the effect of the various inflammatory reactions such as red, secondary, scorching hot, pain of skin, be not easy simultaneously sensitization, be difficult to repeatedly, flavour of a drug are light, drug effect soon can life-time service and do not have side effects.
Description
Technical field
The present invention relates to topical composition field, specially externally applied anti-inflammation, care composition product and preparation technology thereof.
Background technology
In recent years, along with industrial expansion, the deterioration of environment and the abuse of medicine, various dermatosiss are that blowout formula rises
The sickness rate of gesture, particularly scytitis presents explosive growth.Dermatitis, refers to a kind of scytitis, represents skin pair
In chemicals, protein, antibacterial, fungus, the anaphylactic reaction of dry weather etc..These materials can come from outside
Such as articles for washing, it is also possible to the seafood that such as eats from inside, medicine etc..Also the etiology unknown of some dermatitis.Suffer from the people of dermatitis
In general itself being probably allergic constitution, this allergic constitution is genetic, they cutaneous manifestations be eczema,
Dermatitis and urticaria, then show as allergic rhinitis at nose, then shows as allergic asthma at trachea.
The kind of dermatitis and symptom are a lot, and the most common inflammatory reaction is all likely to occur, such as: the reddest: owing to inflammation is sick
In stove, hyperemia is caused, and the inflammation initial stage, locally HbO2 Oxyhemoglobin increased due to arterial hyperemia, therefore in cerise.Along with inflammation
The development of disease, slow blood flow, congestion and stagnation, local organization increases containing reduced hemoglobin, therefore in kermesinus.2. swollen:
Mainly due to exudate, particularly caused by inflammatory edema.During chronic inflammatory disease, the hypertrophy of tissue and cell also can cause local
Swelling.3. heat: heat is owing to arterial hyperemia and metabolism strengthen caused, interleukin I (IL-1) that leukocyte produces,
Tumor necrosis factor (TNF) and prostaglandin E (PGE) etc. all can cause heating.4. pain: local inflammation intralesional potassium from
Accumulation sub, hydrionic, especially inflammatory mediator such as prostaglandin, 5-hydroxy tryptamine, Kallidin I etc. stimulate the pain caused,
In inflammation foci, exudate causes swollen tissue, tension force to increase, and pressuring nerve tip also can cause pain；Inflammation organ enlargement,
Making being increased by layer tension rich in sensory nerve ending, teleneuron is caused pain by tractive.
Pro-inflammatory cytokine (inflammatory agent) refers to that any factor that can cause tissue injury all can become inflammation
Reason.Common scytitis pro-inflammatory cytokine can be that antibacterial, virus, mycoplasma, fungus, spirillum and parasite etc. are raw
The physical agents such as the thing factor, high temperature, low temperature, radioactive substance and ultraviolet etc. and mechanical damage, xenobiotics is such as
Strong acid, highly basic and the chemokines such as Oleum Terebinthinae, mustard gas, allergy etc..
Common scytitis has neurodermatitis, contact dermatitis, and increasing steroid-dependent dermatitis in this year
Deng.Treatment scytitis, typically uses medicine for external use, the medicine for external use of Western medicine predominantly sterilization class and hormones: such as triamcinolone acetonide
Frost, halcinonidedcorten frost, fluocinonide frost etc..But, this kind of medicine typically contains hormone the most very much, although curative effect is fast, but easily
Recurrence, and skin is had side effect, easily form skin keratin, serious also can form steroid-dependent dermatitis.
In terms for the treatment of scytitis, Chinese medicine preparation is the most popular, and various lotions, unguentum the most usually from patient uses.In
The general symptomatic treatment of medicine lotion, is difficult to repeatedly.But, the poor effect that Chinese medicine anti-inflammation formulation is used alone, the course for the treatment of is long, sees
Effect is slow, and abnormal smells from the patient is big when face, it is difficult to use by day.
Accordingly, there exist the new corresponding symptom of research and development is extensive, good drug efficacy, short treating period, abnormal smells from the patient are light externally applied anti-inflammation, care formulations
Demand.
Summary of the invention
Based on the problems referred to above of the prior art, it is desirable to provide one can long acting antibiotic, adapt to symptom extensively, curative effect
Good, short treating period, abnormal smells from the patient are light externally applied anti-inflammation, care composition and preparation method thereof.At the first-line treatment skin that inventor is long-term
On the basis of disease, in conjunction with modern pharmacology theory and practice, filter out one group can effectively treat bacterial dermatitis, fungus dermatitis,
Neurodermatitis, contact dermatitis and steroid-dependent dermatitis and cause various scytitiss reaction.This antiinflammatory, nursing combination
Thing uses pure Chinese medicinal preparation, scientific compatibility, it is possible in the case of without Western medicine sterilizing and hormonal components, reaches skin of sterilizing
The effect of the various inflammatory reactions such as red, secondary, scorching hot, pain, be not easy simultaneously sensitization, be difficult to repeatedly, flavour of a drug are light, drug effect
Soon can life-time service and do not have side effects.
It is an object of the invention to be realized by the description below:
A kind of externally applied anti-inflammation, the compositions of nursing, it is characterised in that be made up of the raw material of following weight portion: Cortex Phellodendri 10-20,
Radix Angelicae Sinensis 5-15, Fructus Cnidii 5-15, Fructus Kochiae 3-10, Radix Sophorae Flavescentis 3-10, Rhizoma Acori Graminei 5-15, white Flos Impatientis 5-15, Rhizoma Atractylodis
7-20, Folium sophorae 5-15, Fructus Xanthii 3-10, Alumen 3-10, Flos Lonicerae 3-10, Rhizoma Smilacis Glabrae 5-15.
A kind of externally applied anti-inflammation, care composition as above, it is characterised in that be made up of the raw material of following weight portion: Cortex Phellodendri
10, Radix Angelicae Sinensis 5, Fructus Cnidii 5, the Fructus Kochiae 3, Radix Sophorae Flavescentis 3, Rhizoma Acori Graminei 5, white Flos Impatientis 5, Rhizoma Atractylodis 7, Folium sophorae 5, grey
The ears or side handles of a utensil 3, Alumen 3, Flos Lonicerae 3, Rhizoma Smilacis Glabrae 5.
Described antiinflammatory, care composition directly can use or obtain rework cost neck after its extract after extracting by pulverizing
Long pigment agent, oil preparation, tincture, gel or the spray seen in territory.
Described antiinflammatory, care composition can use extracting mode common in this area to extract, preferably with water or ethanol
Extract.Preferably extract for a long time with relatively low temperature, such as, extract in the range of 55-90 DEG C, more excellent
It is selected under the temperature conditions of 60-80 DEG C and extracts, most preferably extract under conditions of 65-75 DEG C.Applicant is unexpected
Finding to extract at this temperature, the extract obtained can cause the chance of skin allergy to be substantially reduced.Can be according to medicine
The volume of thing and the instrument of use select suitable extractant addition, and such as 1-20 times, preferred extractant addition is
1-10 times, most preferably 3-5 times.Alcohol extraction can be carried out, it is also possible to individually carry out water extraction after raw material of Chinese medicine elder generation water extraction,
Or alcohol extraction.Described extract can be the extractum concentrated, it is also possible to be dried to powder.
Described antiinflammatory, care composition can be pigment agent, will the direct pulverizing of above-mentioned Chinese crude drug or be made in powder
Medicament extract, can use any means in this area to carry out pulverizing, carry out pulverizing, preferred pulverizing temperature the most at low temperatures
For keep raw material maintain below room temperature in the temperature of milling process, more preferably during pulverizing keep material temperature below 10 DEG C,
Most preferably maintain material temperature at 0-4 DEG C during pulverizing.Compositions after pulverizing can be mixed with cold boiled water or distilled water and wash
Agent, liniment, lotions, suspensoid.Can also directly sell with the form of lotion, liniment, lotions, suspensoid.Add
The water yield is at least to be moistened by whole powder, can mix according to the order of severity of symptom.
Described antiinflammatory, care composition can be oil preparationes, will mix homogeneously with the traditional Chinese medicinal material raw materials after pulverizing and make by vegetable oil,
Medicine can be immersed in vegetable oil and torture, then remove slag.Directly described antiinflammatory, care composition extract can also be added
In vegetable oil.Described vegetable oil can be any oil being derived from plant of skin-tolerant, such as Oleum sesami, Oleum Camelliae, recklessly
Oleum Sesami, Oleum lavandula angustifolia, Oleum menthae etc..The most edible vegetable oil, more preferably Oleum sesami and Oleum menthae, most preferably Herba Menthae
Oil.
Described antiinflammatory, care composition can be tinctures, i.e. directly enter highly concentrated by the compositions after above-mentioned composition or pulverizing
In degree ethanol, the concentration of preferred alcohol is more than 50% (volumetric concentration), more preferably 50%-70%.Described antiinflammatory,
Care composition can also is that unguentum, the extract of compositions after described pulverizing or described compositions will add suitable base
Matter mixing furnishing is uniform, fine and smooth, the dosage form of semi-solid state.Described antiinflammatory, the extract of care composition can also add
Suitable substrate makes Traditional Chinese medicine gel, and described gel can be aqueous gel or oil-base gel, and suitable gel-type vehicle is permissible
For water, glycerol, propylene glycol, cellulose derivative, alginate, gelatin, xanthan gum, starch, paraffin, polyethylene,
Fatty oil, colloidal silicon etc. are made.Described antiinflammatory, care composition can also make spray, and described spray is by described
The extract of antiinflammatory, care composition and/or described important composition jointly encapsulates with suitable propellant and makes.
The externally applied anti-inflammation of the present invention, care composition have the advantages that
(1) the invention provides a kind of antiinflammatory, care composition, it can reach good in the case of without western medicine composition
Good externally applied anti-inflammation effect；
(2) compositions of the present invention has Broadspectrum antiphlogistic effect, for various skins because of pro-inflammatory cytokine cause itch, swollen and red
It is respectively provided with good elimination and inhibition；
(3) antiinflammatory of the present invention, care composition flavour of a drug light, can use by day, it is possible to reduce administration time,
And the Working Life of patient is affected less by light flavour of a drug；
(4) antiinflammatory of the present invention, care composition can not only antiinflammatory, simultaneously can also nurse skin, be difficult to repeatedly, special
It not that the cure rate for steroid-dependent dermatitis is up to more than 95%.
Detailed description of the invention
Below by embodiment, the present invention is specifically described, but following embodiment is not interpreted as limitation of the present invention.
Embodiment 1
A kind of antiinflammatory, care composition, it is made up of following raw material: Cortex Phellodendri 20kg, Radix Angelicae Sinensis 15kg, Fructus Cnidii 15kg,
Fructus Kochiae 10kg, Radix Sophorae Flavescentis 10kg, Rhizoma Acori Graminei 15kg, white Flos Impatientis 15kg, Rhizoma Atractylodis 20kg, Folium sophorae 15kg,
Fructus Xanthii 10kg, Alumen 10kg, Flos Lonicerae 10kg, Rhizoma Smilacis Glabrae 15kg.
Embodiment 2
A kind of antiinflammatory, care composition, it is made up of following raw material: Cortex Phellodendri 15kg, Radix Angelicae Sinensis 8kg, Fructus Cnidii 8kg, ground
Skin 12kg, Radix Sophorae Flavescentis 6kg, Rhizoma Acori Graminei 9kg, white Flos Impatientis 9kg, Rhizoma Atractylodis 9kg, Folium sophorae 12kg, Fructus Xanthii
6kg, Alumen 6kg, Flos Lonicerae 8kg, Rhizoma Smilacis Glabrae 10kg.
Embodiment 3
A kind of antiinflammatory, care composition, it is made up of following raw material: Cortex Phellodendri 10kg, Radix Angelicae Sinensis 5kg, Fructus Cnidii 5kg, ground
Skin 3kg, Radix Sophorae Flavescentis 3kg, Rhizoma Acori Graminei 5kg, white Flos Impatientis 5kg, Rhizoma Atractylodis 7kg, Folium sophorae 5kg, Fructus Xanthii 3kg,
Alumen 3kg, Flos Lonicerae 3kg, Rhizoma Smilacis Glabrae 5kg.
Embodiment 4
The antiinflammatory of embodiment 3, care composition pulverizing at 10 DEG C is crossed 150 mesh sieves, takes compositions 100g after pulverizing subsequently,
It is separately added into 1000ml water, makes lotion.
Embodiment 5
The antiinflammatory of embodiment 3, care composition pulverizing at 10 DEG C is crossed 100 mesh sieves, is subsequently added raw material weight 5 times
Water soaking 48 hours, extracts 60 minutes at 70 DEG C, extracts 3 times, united extraction liquid, and being concentrated into crude drug content is 1.2g
Extractum.
Embodiment 6
The distilled water that the extractum that embodiment 5 prepares adds 30 times is made lotion.
Embodiment 7
The extractum that embodiment 5 prepares is added the water of 20 times, makes spray.
Embodiment 8
The prepared extractum 10g of Example 5, propylene glycol 10g, xanthan gum 2g, sodium alginate 1.5g, distilled water 100g system
Become gel.
The external sterilizing product of the embodiment of the present invention 4,6,8 is carried out respectively the antipruritic and test antiinflammatory with the explanation present invention of subsiding a swelling
Effect, result of the test is as follows:
The most antipruritic test
Take rat 40 (male and female dual-purpose), be randomly divided into 4 groups, often each 5 of male and female of group, to each group of rat left back instep shaving,
Once, comparison is coated with normal saline to coating.Next day, possess at shaving so that coarse sandpaper scratch is left back, area 1cm2, local application 1
Secondary.10min after coating, drips every 0.05ml of 0.01% histamine phosphate to wound surface, hereafter, every 3min according to 0.01
%, 0.02%, 0.03% ... progressive concentration, until occurring that histamine phosphate's total amount that rat is given when later licking wound surface is
Itch-threshold, record the itch-threshold value of relatively more each group, be designated as the itch-threshold value of this group with the meansigma methods of 10 rats.Result is such as
Shown in following table:
* representing P 0.05, * Δ represents P 0.01
Analysis of variance shows, the antiinflammatory of embodiment 4,6,8, care composition product all can significantly improve itch-threshold, especially
Be embodiment 6 and embodiment 8 use extracted after the lotion for preparing as raw material of extractum and gel, antipruritic effect reaches pole
Significant difference.
2. detumescence test
Male mice 40, is randomly divided into 4 groups, is applied to two sides before and after its left ear with 100% dimethylbenzene, every Mus 0.02ml,
Testing the tcm product of position embodiment 4,6,8 according still further to above-mentioned metering and usage after 30 minutes, compareing as normal saline.
By mouse lethal after 4h, cut two ears along auricle baseline, lay in left and right ear same area respectively with the card punch of diameter 6mm
Circle auricle, weighs with analytical balance.Every left auricle of Mus deducts auris dextra sheet and is swelling, and is calculating swelling according to the following formula
Suppression ratio:
Inhibitory rate of intumesce=(A-B) × 100%/A
In formula, A represents the swelling of matched group, and B represents embodiment 4, the swelling of 6,8, result as in the table below:
| Sample number into spectrum | Swelling | Inhibitory rate of intumesce |
| Comparison | 7.15±1.25 | - |
| Embodiment 4 | 4.81±1.07* | 32.72% |
| Embodiment 6 | 4.34±1.16*Δ | 39.30% |
| Embodiment 8 | 4.26±1.23*Δ | 40.42% |
* representing P 0.05, * Δ represents P 0.01
Analysis of variance shows, the antiinflammatory of embodiment 4,6,8, care composition product all can significantly inhibit swelling, particularly
Embodiment 8 use extracted after extractum as raw material prepare gel.
Claims (2)
1. an externally applied anti-inflammation, care composition, it is characterised in that be made up of the raw material of following weight portion: Cortex Phellodendri 10-20, Radix Angelicae Sinensis 5-15, Fructus Cnidii 5-15, Fructus Kochiae 3-10, Radix Sophorae Flavescentis 3-10, Rhizoma Acori Graminei 5-15, white Flos Impatientis 5-15, Rhizoma Atractylodis 7-20, Folium sophorae 5-15, Fructus Xanthii 3-10, Alumen 3-10, Flos Lonicerae 3-10, Rhizoma Smilacis Glabrae 5-15；Its preparation method is condensed into extractum after including extracting upper described raw material of Chinese medicine under conditions of 65-75 DEG C for solvent with water or ethanol.
2. an externally applied anti-inflammation as claimed in claim 1, care composition, it is characterised in that be made up of the raw material of following weight portion: Cortex Phellodendri 10, Radix Angelicae Sinensis 5, Fructus Cnidii 5, the Fructus Kochiae 3, Radix Sophorae Flavescentis 3, Rhizoma Acori Graminei 5, white Flos Impatientis 5, Rhizoma Atractylodis 7, Folium sophorae 5, Fructus Xanthii 3, Alumen 3, Flos Lonicerae 3, Rhizoma Smilacis Glabrae 5.
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| CN105749074A (en) * | 2016-04-26 | 2016-07-13 | 沙挺 | Lotion for treating allergic dermatitis and preparing method of lotion |
| CN106177078A (en) * | 2016-08-10 | 2016-12-07 | 张家港市协和医疗器械有限公司 | A kind of anti-inflammatory ointment |
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| CN1261132C (en) * | 2004-12-09 | 2006-06-28 | 罗玉成 | Traditional Chinese medicine preparation for treating children dermatosis and its preparation method |
| CN102813900B (en) * | 2012-08-21 | 2013-11-13 | 蒋鲁生 | External medicine for treating foot corns |
| CN103239659A (en) * | 2013-05-04 | 2013-08-14 | 朱秋梅 | Medicine for treating gynecologic inflammation and preparation method thereof |
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