CN115282196B

CN115282196B - Preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat and preparation method thereof

Info

Publication number: CN115282196B
Application number: CN202211014022.4A
Authority: CN
Inventors: 刘爱民
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-08-23
Filing date: 2022-08-23
Publication date: 2023-08-08
Anticipated expiration: 2042-08-23
Also published as: CN115282196A

Abstract

The invention discloses a preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis and heat and a preparation method thereof, belonging to the technical field of Chinese herbal medicines. In the prescription, aconite root, radix aconiti carmichaeli and asarum warmth yang strengthen healthy energy to dispel external cold and remove skin stasis heat, ephedra herb warms and dissipates skin stasis heat to dispel external heat, buffalo horn, gardenia, lithospermum, radix paeoniae rubra and caulis spatholobi clear skin stasis heat, and licorice root is used for detoxication and harmonizing the medicines. The whole recipe has both exterior and interior treating effects, cold and warm combining effects, and deficiency and excess coordinating effects, and can restore yin-yang balance of organism. The treatment method comprises the following steps: warm yang and relieve exterior syndrome, cool blood and clear heat. Treating main symptoms: the skin damage recurs or aggravates in autumn and winter after long time of illness, erythema is lighter or red, scales are thin, cold intolerance, cold hands and feet are cold, or eating is poor, and loose stool is thin. A pale and fat tongue with a thin and white coating and a deep and weak pulse. Is aimed at psoriasis caused by yang deficiency and external cold, skin heat stasis, namely deficiency-cold in body and skin heat stasis, and recurrent or aggravated skin damage after autumn and winter.

Description

Preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat and preparation method thereof

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and in particular relates to a preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis and heat and a preparation method thereof.

Background

Yang deficiency with exterior cold and skin stagnant heat generally refers to the condition that the body of a patient belongs to the constitution of deficiency cold, and blood heat or stagnant heat of the surface of the muscle is also clamped in the body of the patient, which belongs to the condition of coexistence of pathological conditions. When the external environment is in a cold state, the body hair orifices are blocked, the external cold causes the yang qi which is weakened by the external cold to be more damaged, and meanwhile, the blood heat or the stagnant heat of the muscle surface is difficult to dissipate, so that the psoriasis skin damage is caused.

There has been a disclosure of the use of immune cell preparations to treat psoriasis from a biological genomic perspective. The technology comprises the steps of collecting blood, separating mononuclear cells from the blood, and adding culture solution into the mononuclear cells to obtain a basic culture system; adding human serum and IFN-gamma into the basic culture system to obtain a primary culture system, culturing the primary culture system in an incubator for the first time, and then adding IL-2, CD3McAb and IL-1 to obtain a secondary culture system; and (3) performing secondary culture on the obtained secondary culture system in an incubator, supplementing a nutrient solution into the secondary culture system every 3 days, harvesting and separating cells after the secondary culture is finished, and washing the cells with sterile physiological saline to obtain the immune cell preparation for treating psoriasis. The biological genetic immunocyte preparation is suitable for the preparation based on the generation of diseases caused by the body immunity decline of patients.

The related art discloses a compound preparation for adjuvant therapy of psoriasis, comprising: 3.919-7.488 parts of an auxiliary psoriasis treatment composition, 1.0-1.5 parts of a suspension thickening agent, 7-10 parts of a humectant, 8-10 parts of an emollient, 0.5-2.5 parts of an antioxidant and water; the composition for the adjuvant treatment of psoriasis comprises: a composition for improving skin microcirculation comprises Notoginseng radix total saponin, radix Pseudostellariae extract and horse chestnut saponin; a composition for correcting skin keratinization comprising sulfonated shale oil and lentil seed extract; a skin barrier repair composition consisting of prinsepia utilis royle oil, panthenol and hydrolysed yeast protein; an anti-inflammatory and anti-irritant composition comprises centella asiatica extract, calendula extract and ammonium glycyrrhizate. The preparation belongs to an external preparation, aims at the skin surface layer, improves the microcirculation of the skin in a compound composition mode, scientifically combines active substances through multiple ways of softening cutin, correcting skin keratinization abnormality, strengthening capillaries, improving microcirculation, repairing skin barrier function, resisting inflammation and relieving itching, is assisted with moisturizing and nourishing components, and cooperatively and effectively assists in treating psoriasis. The preparation is used for treating diseases by starting from the external protective layer.

The related art discloses a pharmaceutical composition for treating psoriasis, which is characterized by comprising the following active substances in parts by weight: 5-12 parts of matrine, 4-10 parts of glycyrrhizic acid, 8-15 parts of fraxinellone, 3-11 parts of cimicifuga rhizome glycoside, 8-20 parts of glabrous greenbrier rhizome total flavone, 7-18 parts of cicada slough extract, 2-8 parts of phellodendron bark aqueous extract, 5-15 parts of catalpol, 6-20 parts of honeysuckle flower alcohol extract, 2-8 parts of red paeony root total glycoside, 4-15 parts of forsythin and 4-10 parts of angelica polysaccharide. The composition is used for treating psoriasis, and has effects in dispelling pathogenic wind, removing dampness, clearing heat and toxic materials, promoting blood circulation, and dispelling blood stasis.

The related art discloses a medicament for treating psoriasis, which is prepared from the following traditional Chinese medicines in parts by weight: 10 g of Chinese angelica, 10 g of ligusticum chuanxiong, 12 g of white peony root, 15 g of radix rehmanniae, 10 g of radix sophorae flavescentis, 10 g of amur corktree bark, 12 g of fructus kochiae, 15 g of glabrous greenbrier rhizome, 12 g of fructus forsythiae, 12 g of honeysuckle, 10 g of divaricate saposhnikovia root, 15 g of cortex dictamni, 10 g of achyranthes root, 12 g of red sage root, 10 g of radix curcumae and 6 g of spina gleditsiae. The medicine is formulated into decoction. The four materials of the Chinese angelica, the ligusticum chuanxiong, the white paeony root and the dried rehmannia root in the prescription have the effects of enriching and moistening blood, activating blood and dissolving stasis, tonifying heart and nourishing liver and kidney; the kuh-seng, the glabrous greenbrier rhizome, the amur corktree bark and the belvedere fruit have the functions of clearing away heat and toxic materials, eliminating dampness, killing parasites and relieving itching; fructus forsythiae and flos Lonicerae have effects of dispelling pathogenic wind, heat and toxic materials; radix Saposhnikoviae and cortex Dictamni Radicis have effects of dispelling pathogenic wind, relieving itching, and eliminating wind toxin of liver and lung; the red sage root and the achyranthes have the effects of activating blood, dissolving stasis and benefiting liver; radix Curcumae has effects of activating qi-flowing, resolving stagnation and relieving stagnation; spina Gleditsiae has effects of dredging channels, relieving swelling and dispelling pathogenic wind. The medicines are matched and used for synergistic effect, and can enrich blood, promote blood circulation, moisten blood, promote tissue regeneration and remove blood stasis, clear away heat and toxic materials, dispel wind, remove dampness, regulate qi and remove stagnation, and promote menstruation and detumescence, namely the medicine is mainly used for treating psoriasis caused by blood dryness.

Disclosure of Invention

The invention aims to provide a preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis and heat and a preparation method thereof, which are used for solving the technical problems that in the prior art, a medicine product is mainly aiming at psoriasis caused by blood dryness, but the medicine product is not aiming at body deficiency and cold but is clamped with blood heat or stasis and heat of muscle surface.

The invention is realized by the following technical scheme:

a preparation for treating psoriasis caused by yang deficiency, external cold and skin stasis heat is mainly prepared from the following raw materials in parts by mass:

8-15 parts of raw ephedra herb, 7-13 parts of prepared aconite root, 4-8 parts of asarum, 24-45 parts of buffalo horn, 10-18 parts of gardenia, 16-30 parts of lithospermum, 12-24 parts of red paeony root, 24-45 parts of suberect spatholobus stem and 5-9 parts of raw liquorice.

The prescription solution of the prescription is as follows: in the formula, aconite root, radix aconiti carmichaeli and asarum warmth yang strengthen the body resistance to dispel external cold and remove skin stasis heat, ephedra herb warms and dissipates skin stasis heat to dispel external heat, buffalo horn, gardenia, lithospermum, radix paeoniae rubra and caulis spatholobi clear skin stasis heat, and raw licorice root detoxicates and reconciles the medicines. The whole recipe has both exterior and interior treating effects, cold and warm combining effects, and deficiency and excess coordinating effects, and can restore yin-yang balance of organism. The treatment method comprises the following steps: warm yang and relieve exterior syndrome, cool blood and clear heat.

Preferably, the preparation is mainly prepared from the following raw materials in parts by mass:

10 parts of raw ephedra herb, 9 parts of prepared aconite root, 5 parts of asarum herb, 30 parts of buffalo horn, 12 parts of gardenia, 20 parts of lithospermum, 15 parts of red paeony root, 30 parts of suberect spatholobus stem and 6 parts of raw liquorice.

Raw ephedra herb and Chinese medicine name. Is the grass stem of herba Ephedrae Ephedra sinica Stapf, herba Ephedrae Ephedra intermedia Schrenk et C.A.Mey or herba Equiseti hiemalis Ephedra equisetina Bge of Ephedraceae genus herba Ephedrae. Has effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, relieving asthma, inducing diuresis and relieving edema. It is used for treating common cold due to wind-cold, cough, asthma, and edema due to wind and water. Pungent and slightly bitter in taste and warm in nature; enter lung and bladder meridians. The main ingredient of the product is ephedrine, and contains a small amount of pseudoephedrine, volatile oil, flavonoid compounds, ephedra polysaccharide and the like.

Prepared aconite root, which refers to the processed product of aconite root, includes "salted aconite root", "Heishun tablet" and "Baifu tablet". Because of the relatively high toxicity of aconite, it is usually used after processing to achieve the aim of reducing toxicity and enhancing efficacy. The traditional medicine considers that the prepared aconite root has the characteristics of pungent, sweet and hot property, is toxic, returns to heart, kidney and spleen meridians, has the effects of restoring yang and rescuing the adverse reaction, tonifying fire and supporting yang, dispelling cold and relieving pain, and is used for treating the symptoms of yang exhaustion and collapse, limb cold pulse deficiency, heart yang deficiency, chest stuffiness and pain, deficiency cold vomiting and diarrhea, epigastralgia, deficiency of kidney-yang, impotence and cold womb, yin cold edema, yang deficiency exogenous pathogenic factor, cold dampness and pain. Returnal emission rescue: the prepared aconite root has the advantages of strong medicinal property Xin Dare, pure yang dryness and strong effect of tonifying primordial yang and dispelling yin cold, and can be used for treating primordial yang deficiency and skin cold pulse. Tonifying fire and supporting yang: prepared aconite root, radix Aconiti lateralis Preparata has the property of being pungent and warm in nature, and can strengthen heart yang to promote blood circulation, warm spleen yang to dispel cold, and lower kidney yang to benefit fire, and can reach the effect of removing exterior cold from fur. Can be used for treating deficiency of heart-yang, chest pain, emesis and diarrhea due to deficiency-cold, abdominal pain, kidney yang deficiency, sexual impotence, cold womb, edema due to yin-cold, and exogenous pathogenic factor due to yang deficiency. Dispelling cold and relieving pain: the prepared aconite root has the effects of warming and dredging channels and collaterals, expelling pathogenic wind-cold-dampness in channels and collaterals, and has stronger effects of dispelling cold and relieving pain, and is suitable for treating wind-cold-dampness arthralgia and general bone joint pain, especially for treating severe cold arthralgia.

Asarum herb and Chinese medicine name. Is root and rhizome of Asarum sieboldii Miq.var. The first two are known as "Liaochun". Has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, inducing resuscitation, warming lung, and resolving fluid retention. It is used for treating common cold due to wind-cold, headache, toothache, rheumatalgia, nasosinusitis, and cough due to lung cold. Pungent taste and warm nature; it enters lung, kidney and heart meridians. The volatile oil, water and alcohol extract of herba asari have antipyretic, antiinflammatory, tranquilizing, anticonvulsive and local anesthesia effects respectively; the volatile oil can excite and inhibit the central nervous system at a large dose, and has certain toxic and side effects. In vitro tests have inhibitory effect on production of Streptococcus hemolyticus, bacillus dysenteriae and aflatoxin. Hua Xixin alcoholic infusion can combat morphine-induced respiratory depression. The racemized desmethyl linderane has effects of strengthening heart, dilating blood vessel, relaxing smooth muscle, enhancing lipid metabolism, and increasing blood sugar. The safrole contained in the composition has strong toxicity, is a cancerogenic substance and is easy to destroy at high temperature.

Cornu Bubali and Chinese medicinal herbs. Is cornu Bubali Bubalus bubalis Linnaeus of Bubali of Bubalidae, and is a substitute for cornu Rhinocerotis. Has effects of clearing heat, cooling blood, removing toxic substances, and arresting convulsion. Is mainly used for treating epidemic febrile disease, coma, delirium, convulsion, mania, blood heat, delusions and maculata, hematemesis, carbuncle, swelling and sore throat. Bitter taste and cold nature; it enters heart and liver meridians. The extract and water decoction have heart strengthening effect; the injection has the effects of reducing blood pressure, increasing platelet count, shortening clotting time, reducing capillary permeability, resisting inflammation, etc., and the decoction has the effects of relieving convulsion and fever, and has obvious protective effect on mice challenged by Escherichia coli and beta-streptococcus hemolyticus, and exciting effect on pituitary-adrenal cortex system. The product contains cholesterol, peptides, various amino acids, and various microelements.

Gardenia and traditional Chinese medicine name. Is dried mature fruit of Gardenia jasminoides Ellis Cardenia jasminoides Ellis of Gardenia of Rubiaceae. Has effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood, and removing toxic substances. Is mainly used for treating febrile vexation, damp-heat jaundice, blood stranguria, hematemesis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to fire toxin.

Radix Arnebiae, and its name. Is root of Arnebia euchroma (Royle) Johnst. Of Arnebia of Arnebiae of Arnebiaceae, arnebia A.guttata Bunge and Arnebia Lithospermum erythrorhizon Sieb.et Zucc. Has effects of clearing heat, cooling blood, promoting blood circulation, removing toxic substance and promoting eruption. Is mainly used for treating warm diseases with syndrome of excessive heat and toxin, macula, purple black, measles, pyocutaneous disease, eczema, and scald due to water and fire. Sweet and salty in taste, cold in nature; it enters heart and liver meridian. The product contains shikonin (shikonin), shikonin, acetylshikonin, deoxyshikonin, isobutyryl shikonin, dimethyl pentenoyl shikonin, beta-dimethyl propenoyl shikonin, etc. The decoction, shikonin, dimethyl pentenoyl shikonin, and dimethyl propenoyl shikonin have inhibiting effect on Staphylococcus aureus, escherichia coli, bacillus subtilis, etc.; shikonin has obvious inhibiting effect on escherichia coli, typhoid bacillus, bacillus dysenteriae, pseudomonas aeruginosa and staphylococcus aureus. The ether, water and ethanol extracts have certain anti-inflammatory effect. The sinkiang arnebia root decoction has obvious excitation effect on heart. Shikonin and petroleum ether extracted from radix Arnebiae of Sinkiang have anti-tumor effect. The product has effects in resisting fertility and relieving fever.

Red peony root, chinese medicine name. Is dry root of Paeonia lactiflora Paeonia lactiflora pall or Paeonia lactiflora P.veitchii Lynch. Has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis. Is mainly used for treating toxic heat with symptoms of macula, hematemesis, epistaxis, conjunctival congestion, swelling and pain, carbuncle, swelling and sore, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain and traumatic injury. Bitter taste and slightly cold nature; enter liver meridian. The product contains paeoniflorin, albiflorin, oxidized paeoniflorin, benzoylpaeoniflorin, peoniflorin, paeoniflorin, gallotannins, benzoic acid, volatile oil, fatty oil, resin, etc. The product has effects in dilating coronary artery and increasing coronary blood flow; the radix Paeoniae Rubra aqueous extract, radix Paeoniae Rubra glycoside, radix Paeoniae Rubra component and its derivatives have platelet aggregation inhibiting effect; the decoction can prolong in vitro thrombosis time and reduce dry weight of thrombus. The paeoniflorin has sedative, antiinflammatory and analgesic effects. Paeonia lactiflora fluid extract and paeoniflorin have anticonvulsive effect. Radix Paeoniae Rubra and paeoniflorin have spasmolytic effect; the red paeony root has obvious enhancement function on the synthesis of the liver cell DNA and has stronger inhibition function on various pathogenic microorganisms.

Caulis Spatholobi, the name of Chinese traditional medicine. Is dried rattan of Sparassis crispa Spatholobus suberectus Dunn belonging to genus Sparassis of family Leguminosae. Has effects of promoting blood circulation, replenishing blood, regulating menstruation, relieving rigidity of muscles, and activating collaterals. Is mainly used for treating irregular menstruation, dysmenorrhea, amenorrhea, rheumatalgia, numbness of hands and feet, paralysis of limbs and sallow complexion due to blood deficiency.

The radix Glycyrrhrizae is dry root and rhizome of Glycyrrhiza uralensis Fisch.L.of Leguminosae, glycyrrhiza uralensis Fisch.L.or Glycyrrhiza glabra. Mainly produced in inner Mongolia, shaanxi, gansu and northeast China. The traditional medicine considers that liquorice has sweet and flat property, returns to heart, lung, spleen and stomach channels, has the effects of invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain and harmonizing various medicines, is used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough with excessive phlegm, epigastric and abdominal or limb contracture pain, carbuncle and sore toxin, and can also be used for relieving drug toxicity and intensity. The triterpenoid saponin glycyrrhizic acid is contained, potassium and calcium salts of the triterpenoid saponin glycyrrhizic acid are glycyrrhizin, are sweet components in liquorice, and generate 2 molecules of glucuronic acid and 1 molecule of 18 beta-glycyrrhetinic acid after hydrolysis. Comprises glycyrrhizin A3, B2, C2, D3, F3, G2, H2, J2 and K2. Flavonoid compounds separated from Glycyrrhrizae radix are more, and are effective components for resisting ulcer and relieving spasm, and comprise New Zealand semen Jing Gan, licoflavone, isoflavone, and glycyrrhizin. Separating tetrahydroquinoline compound from the extract; alkaloid such as 5,6,7, 8-tetrahydro-2, 4-dimethylquinoline, etc. Recently, monoisoflavone compound (II), licoisoflavone and licoisoflavone were newly isolated, and licocoumarone having antioxidant and antimicrobial properties and 5 licocoumarin derivatives inhibiting cell permeation of human immunodeficiency virus were isolated, which were named as licopyranocoumarin.

A preparation method of a preparation for treating psoriasis caused by yang deficiency, external cold and skin stasis heat comprises the following steps:

mixing raw ephedra, prepared aconite root, asarum, buffalo horn, gardenia, lithospermum, red paeony root, suberect spatholobus stem and raw liquorice according to the corresponding mass fractions as raw materials, and soaking;

decocting the above mixed materials until boiling, pouring out decoction, decocting again, repeatedly decocting, collecting each decoction, and mixing into a whole;

concentrating the decoction.

Preferably, the soaking is performed by adding 3-5 times of water.

Preferably, the soaking time is 30-50min.

Preferably, the time period from boiling to boiling is 1-1.5 h/time.

Preferably, the decoction temperature is 80-110 ℃.

Preferably, the re-decoction time is 40-60 min/time.

Preferably, the repeated decoction is repeated for 1-3 times.

Preferably, the concentration temperature is not lower than 60 ℃.

Compared with the prior art, the invention has at least the following technical effects:

the invention provides a preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat, which is prepared by mixing raw ephedra, prepared aconite root, asarum, buffalo horn, gardenia, lithospermum, red paeony root, suberect spatholobus stem and raw liquorice.

In the prescription, the aconite root and the asarum warms yang and strengthens the body resistance to dispel external cold and remove skin stasis and heat, the ephedra herb warms and dissipates skin stasis and heat to dispel external heat, the buffalo horn, the gardenia, the lithospermum, the red paeony root and the suberect spatholobus stem clear and remove skin stasis and heat, and the raw licorice root detoxifies and reconciles the medicines. The whole recipe has both exterior and interior treating effects, cold and warm combining effects, and deficiency and excess coordinating effects, and can restore yin-yang balance of organism.

The treatment method of the prescription comprises the following steps: warm yang and relieve exterior syndrome, cool blood and clear heat.

The main symptoms of the prescription are: the skin damage recurs or aggravates in autumn and winter after long time of illness, erythema is lighter or red, scales are thin, cold intolerance, cold hands and feet are cold, or eating is poor, and loose stool is thin. A pale and fat tongue with a thin and white coating and a deep and weak pulse.

The prescription is used for treating psoriasis caused by yang deficiency and external cold and skin heat stasis, namely deficiency-cold, skin heat stasis and skin heat accumulation, and recurrent or aggravated skin damage after autumn and winter.

Drawings

FIG. 1 is a schematic representation of a pre-treatment condition for patient 1;

FIG. 2 is a schematic representation of a condition in treatment of patient 1;

figure 3 is a schematic representation of a post-treatment condition for patient 1.

FIG. 4 is a schematic diagram of a pre-treatment condition for patient 2;

figure 5 is a schematic representation of a post-treatment condition for patient 2.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to the following examples, which are to be construed as merely illustrative and not limitative of the scope of the invention, but are not intended to limit the scope of the invention to the specific conditions set forth in the examples, either as conventional or manufacturer-suggested, nor are reagents or apparatus employed to identify manufacturers as conventional products available for commercial purchase.

Example 1:

according to the corresponding mass fractions, 800 g of raw ephedra, 700 g of prepared aconite, 400 g of asarum, 2400 g of buffalo horn, 1000 g of gardenia, 1600 g of lithospermum, 1200 g of red paeony root, 2400 g of suberect spatholobus stem and 500 g of raw liquorice are mixed as raw materials, and are soaked in 33000 g of water for 50min;

decocting the above mixed materials at 110deg.C for 1 hr, pouring out decoction, decocting again for 60min, repeating the decoction for 2 times, collecting each decoction, and mixing;

concentrating the decoction at 60deg.C or higher.

Example 2:

according to the corresponding mass fractions, 800 g of raw ephedra, 700 g of prepared aconite, 400 g of asarum, 2400 g of buffalo horn, 1000 g of gardenia, 1600 g of lithospermum, 1200 g of red paeony root, 2400 g of suberect spatholobus stem and 500 g of raw liquorice are mixed as raw materials and soaked in 55000 g of water for 30min;

decocting the above mixed materials at 80deg.C for 1.5 hr, pouring out decoction, decocting again for 40min, repeating the decoction for 1 time, collecting each decoction, and mixing;

concentrating the decoction at 60deg.C or higher.

Example 3:

1500 g of raw ephedra, 1300 g of prepared aconite, 800 g of asarum, 4500 g of buffalo horn, 1800 g of gardenia, 3000 g of lithospermum, 2400 g of red paeony root, 4500 g of suberect spatholobus stem and 900 g of raw liquorice according to the corresponding mass fractions are mixed as raw materials, and are soaked in 62100 g of water for 30min;

decocting the above mixed materials at 110deg.C for 1 hr, pouring out decoction, decocting for 40min again, repeating the decoction for 2 times, collecting each decoction, and mixing;

concentrating the decoction at 60deg.C or higher.

Example 4:

1500 g of raw ephedra, 1300 g of prepared aconite, 800 g of asarum, 4500 g of buffalo horn, 1800 g of gardenia, 3000 g of lithospermum, 2400 g of red paeony root, 4500 g of suberect spatholobus stem and 900 g of raw liquorice according to the corresponding mass fractions are mixed as raw materials, and are soaked in 103500 g of water for 50min;

decocting the above mixed materials at 110deg.C for 1.5 hr, pouring out decoction, decocting again for 60min, repeating the decoction for 2 times, collecting each decoction, and mixing;

concentrating the decoction at 60deg.C or higher.

Example 5:

1000 g of raw ephedra, 900 g of prepared aconite, 500 g of asarum, 3000 g of buffalo horn, 1200 g of gardenia, 2000 g of lithospermum, 1500 g of red paeony root, 3000 g of suberect spatholobus stem and 600 g of raw liquorice are mixed according to the corresponding mass fractions to be used as raw materials, and water is added for 30550 g to soak for 30min;

decocting the above mixed materials at 80deg.C for 1.5 hr, pouring out decoction, decocting again for 60min, repeating the decoction for 3 times, collecting each decoction, and mixing;

concentrating the decoction at 60deg.C or higher.

Example 6:

1000 g of raw ephedra, 900 g of prepared aconite, 500 g of asarum, 3000 g of buffalo horn, 1200 g of gardenia, 2000 g of lithospermum, 1500 g of red paeony root, 3000 g of suberect spatholobus stem and 600 g of raw liquorice are mixed according to the corresponding mass fractions to serve as raw materials, and are soaked in 50950 g of water for 50min;

decocting the above mixed materials at 80deg.C for 1 hr, pouring out decoction, decocting again for 40min, repeating the decoction for 3 times, collecting each decoction, and mixing;

concentrating the decoction at 60deg.C or higher.

The administration mode of the prescription is as follows: 2 times daily.

Clinical cases:

patient 1: men, 55 years of age, pre-treatment condition: first diagnosis in 2020, 12 months and 19 days. Complaints: systemic generalized scaly erythema, repeated for 17 years. The current medical history: the patient has no obvious cause of scaly red patch on scalp before 17 years, rapidly spreads the whole body, is treated in Zhengzhou certain trimethyl hospital, orally takes compound glycyrrhizin, abamectin A and tripterygium glycosides, externally uses calcipotriol and compound clobetasol propionate ointment, and has continuous illness state and repeated attack. The symptoms are as follows: hairline, head top part pale red stain, silvery white scale, hair in bundle shape, chest and abdomen, waist and back, and double upper limb stretching side generalized scale erythema, partially fused into pieces, shank large piece erythema, dry desquamation, and pruritus. The skin injury is serious in winter and light in summer, aversion to cold, cold hands and feet, dry mouth, wen Yin, anorexia, general sleep and the like. Tonsil grade I swelling and congestion. A pale tongue with white, thick and greasy coating and a weak pulse. Diagnosis: western diagnosis: psoriasis. Syndrome type: yang deficiency and exterior cold, blood heat and dampness. The treatment method comprises the following steps: warm yang, dispel cold, cool blood and remove dampness. The product prepared in example 6 was used 2 times/day. 2021-01-03 two diagnosis: after taking the medicine, aversion to cold is relieved, skin damage is relieved, pulse is still clear, tongue is dark, tongue coating is white and thick, and it is suggested that the damp-removing and collaterals-dredging are aggravated in addition to warming yang. 2021-02-17 three diagnosis: the skin lesions are obviously thinned after the medicine, the color is light, part of the skin lesions are resolved, the tongue is pale, the coating Bao Nilve is yellow, and the pulse is weak to the right. 2021-04-03 four diagnostic methods: the skin lesions basically subside, but a little pimple is formed, the stool is still loose, the tongue is pale red, the coating is thick and greasy, the pulse is slightly wiry, the skin lesions subside, and the weather is warm, so that the dispersing force is preferably lightened. 2021-05-04 five diagnosis: the skin lesions resolved, only the small spots on the lower leg, pale tongue with white coating and proper pulse.

Patient 1 is shown in figure 1 as being in a pre-treatment condition; as shown in figure 2, the condition is in the treatment of patient 1; patient 1 is shown in figure 3 as a post-treatment condition.

Patient 2: women, 28 years old, 2022, month 17 days of initial diagnosis. Complaints: the head, waist, back and vulva are scaly erythema with itching for 6 years. Disease conditions: the disease course of the patient is as long as 6 years, and the curative effect is poor at many places. Skin loss is light red and dry, aversion to cold, cold hands and feet are not warm, cold sweat is easy to occur in both hands, chilblain is often caused, tongue is pale, and the chronic value is in winter, and the skin loss is the symptoms of yang deficiency, external cold, blood deficiency and dryness-heat; fat tongue with white and greasy coating suggests spleen deficiency and dampness accumulation. The disease is a disease with long course, complex pathogenesis, and complicated cold and heat. The pathogenesis of patients is that the body yang is weak, the wei yang is insufficient, the external cold is easy to cause the yang deficiency to be more serious, and cold stagnation leads to the depression and the closure of striae, and the blood heat stasis and heat stasis of the muscle surface are difficult to reach outside, so the skin damage is caused. The traditional Chinese medicine differentiation is that yang deficiency and external cold and blood heat and dampness accumulation syndrome are treated by mainly warming and dispersing, and by assisting with clearing heat and cooling blood and nourishing blood, the pathogenic factors have a way out, and the skin damage is naturally resolved. The current medical history: patients have no obvious cause of the above symptoms before 6 years, and once diagnosed as psoriasis in a plurality of hospitals, the curative effect is poor after treatment (in detail). The symptoms are as follows: the patient's scalp has large erythema and desquamation, the waist and back parts are scattered with a little erythema, and the face is little pimple and acne. Patients are averse to cold, hands and feet are not warm in winter, cold sweat is easy to occur in both hands, chilblain is often caused, sleep is easy, and menstruation is normal. A pale and fat tongue with white and greasy coating and a thready and weak pulse. Diagnosis: western diagnosis: psoriasis. Diagnosis of traditional Chinese medicine: white porrigo. Syndrome type: yang deficiency and exterior cold, and blood heat and dampness. The treatment method comprises the following steps: warming yang, dispelling cold, clearing heat, cooling blood and removing dampness. The product prepared in example 6 was used 2 times/day. 2022-03-02 two diagnosis: after the medicine is applied, the scalp, trunk and vulva skin lesions basically subside, and the scalp, trunk and vulva are thin, the face is yellow and dark, the hypodynamia, the sweats are easy, the tongue is pale and fat, the coating is white and greasy, and the pulse is thin and weak.

Patient 2 is shown in figure 4 as a pre-treatment condition; patient 2 is shown in figure 5 for a post-treatment condition.

Patient 3: the patient was male, 65 years old, with a 5 year history of psoriasis. The complaint of this visit is that the scalp and hip appear red spot scales with itching for 5 years. Before 5 years, the skin of the patient is covered by the shaoyang on both sides of the head, the back and the hip are provided with scaly red spots, the itching is obvious, and the effect is poor when the skin is treated in a hospital. The existing skin has numerous rashes, itching, anorexia, dry mouth and 1 time of daily defecation, which are loose stools. Plain, urgent and irritable. A red tongue tip, a thin and yellow coating and a wiry and rapid pulse. According to the differentiation of the syndrome system, the syndrome differentiation is the syndrome of blood heat, and the pathogenesis is the stagnation of liver-channel heat into blood. Considering the old patients with deficiency of yang-qi and weakness of spleen and stomach, care should be taken to protect the spleen and stomach. The patients have a history of 5 years, and the patients take the stagnation of qi and blood stasis due to yin impairment caused by heat. The product prepared in example 6 was used 2 times/day. After 2 weeks, the scalp and back skin lesions basically subside, and the stool condition is improved. The skin damage is basically completely resolved after the medicine is continuously taken for 2 weeks, the curative effect is consolidated after the medicine is continuously taken for 2 weeks, and no recurrence is caused after the follow-up for 2 years.

The example is the elderly patient, the skin damage and four diagnoses all find obvious heat pattern, and the combination of viscera and channels considers the stagnated heat of liver channel and spleen deficiency, and the recipe is satisfied by adding and subtracting the treatment to the Danzhi Xiaoyao san. However, the old patients had loose stool and sugar, which suggests the insufficiency of spleen-yang, and the dry mouth suggests the insufficiency of yin-fluid. The main contradiction of blood heat is grasped, the secondary contradiction of spleen deficiency and yin injury is treated, the physique characteristics of the elderly are emphasized, and the prescription is used for medicine preparation, so that the curative effect is natural and reliable.

Patient 4: female patient, 64 years old. The whole body is treated by the treatment of the scaling erythema accompanied with itching for 3 years, so that the itching caused by the scaling erythema with different sizes and the systemic distribution is diagnosed. The pain in the back is frequent, the tongue is pale and dark, the tongue is ecchymosis, the coating is thin and white, and the pulse is deep and weak. According to the differentiation of the syndrome system, the syndrome differentiation is the syndrome of blood dryness, the etiology and pathogenesis are the deficiency of qi and blood, and the stasis heat is retained. Considering elderly patients, they are tonifying qi and replenishing blood. The product prepared in example 6 was used 2 times/day. The skin lesions substantially resolved for 2 months.

Finally, it should be noted that: the foregoing description is only of the preferred embodiments of the invention and is not intended to limit the scope of the invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The preparation for treating psoriasis caused by yang deficiency, external cold and skin stasis heat is characterized by being prepared from the following raw materials in parts by weight:

2. The preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight:

3. A method for preparing the preparation for treating psoriasis caused by yang deficiency, external cold and skin stasis heat according to claim 1 or 2, comprising the following steps:

mixing and soaking raw ephedra, prepared aconite, asarum, buffalo horn, gardenia, lithospermum, red paeony root, suberect spatholobus stem and raw liquorice according to the corresponding parts by weight;

concentrating the decoction.

4. The method for preparing the preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 3, wherein the soaking is carried out by adding 3-5 times of water.

5. The method for preparing the preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 4, wherein the soaking time is 30-50min.

6. The method for preparing the preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 3, wherein the decoction time period after boiling is 1-1.5h.

7. The method for preparing the preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 6, wherein the decoction temperature is 80-110 ℃.

8. The method for preparing the preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 3, wherein the re-decoction time period is 40-60min.

9. The method for preparing a preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 3, wherein the repeated decoction is repeated for 1-3 times.

10. The method for preparing a preparation for treating psoriasis caused by yang deficiency and external cold and skin stasis heat according to claim 3, wherein the concentration temperature is not lower than 60 ℃.