CN111529632A

CN111529632A - Traditional Chinese medicine formula for treating infantile epistaxis and preparation method thereof

Info

Publication number: CN111529632A
Application number: CN202010420499.7A
Authority: CN
Inventors: 蔡建华; 蔡镇宇; 蔡涵宇
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-18
Filing date: 2020-05-18
Publication date: 2020-08-14

Abstract

The invention relates to a traditional Chinese medicine formula for treating infantile epistaxis, which comprises the following raw materials in parts by weight: group A: 50-80 parts of bletilla striata, 50-75 parts of scutellaria baicalensis, 20-50 parts of gentian, 10-30 parts of raw liquorice, 70-100 parts of fried lotus node and 70-100 parts of fried sophora flower; group B: 80-100 parts of cogongrass rhizome, 50-65 parts of red peony root, 50-65 parts of moutan bark, 50-65 parts of gardenia jasminoides, 110-140 parts of hairyvein agrimony and 60-90 parts of herba nonanthi praeparata; group C: 20-50 parts of Senecio cannabifolius less, 50-80 parts of Japanese thistle herb, 50-80 parts of white mulberry root-bark, 40-70 parts of carbonized human hair, 50-65 parts of cacumen biotae, 20-35 parts of rheum officinale and 50-80 parts of radix ophiopogonis; group D: 50-65 parts of callicarpa bodinieri, 70-100 parts of clinopodium polycephalum, 50-65 parts of euphorbia hirta, 70-110 parts of charred schizonepeta, 50-65 parts of charred cattail pollen and 70-100 parts of charred madder. The formula has no adverse reaction and side effect, no dependence, safety and reliability, and no recurrence.

Description

Traditional Chinese medicine formula for treating infantile epistaxis and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for treating infantile epistaxis and a preparation method thereof.

Background

The infantile epistaxis refers to nasal bleeding caused by rupture of blood vessels in nasal cavity, nasal sinuses or nasopharynx, and is a common symptom, and mild cases are bloody nasal discharge or punctate blood drops. In severe cases, massive hemorrhage is not easy to control, and hemorrhagic shock can be caused. According to incomplete statistics, nearly 0.5-1% of children aged 2-10 years in China have symptoms of excessive nosebleed, so that parents of many children feel very vexation, most commonly used for quickly treating the nosebleed of the children at present is the chlorphenamine, and although the chlorphenamine takes effect quickly, the chlorphenamine takes temporary symptoms instead of permanent symptoms, and is easy to relapse.

According to our knowledge, no Chinese patent medicine specially used for treating the nosebleed of teenagers is found in the market of China, which is exactly regret. Therefore, the method for treating epistaxis by using the traditional Chinese medicine is very important.

Disclosure of Invention

One of the objects of the present invention is: provides a traditional Chinese medicine formula with good effect and difficult recurrence for treating the epistaxis of children.

In order to achieve the above purpose, the invention provides the following technical scheme:

a traditional Chinese medicine formula for treating infantile epistaxis comprises the following raw materials in parts by weight:

group A: 50-80 parts of bletilla striata, 50-75 parts of scutellaria baicalensis, 20-50 parts of gentian, 10-30 parts of raw liquorice, 70-100 parts of fried lotus node and 70-100 parts of fried sophora flower;

group B: 80-100 parts of cogongrass rhizome, 50-65 parts of red peony root, 50-65 parts of moutan bark, 50-65 parts of gardenia jasminoides, 110-140 parts of hairyvein agrimony and 60-90 parts of herba nonanthi praeparata;

group C: 20-50 parts of Senecio cannabifolius less, 50-80 parts of Japanese thistle herb, 50-80 parts of white mulberry root-bark, 40-70 parts of carbonized human hair, 50-65 parts of cacumen biotae, 20-35 parts of rheum officinale and 50-80 parts of radix ophiopogonis;

group D: 50-65 parts of callicarpa bodinieri, 70-100 parts of clinopodium polycephalum, 50-65 parts of euphorbia hirta, 70-110 parts of schizonepeta charcoal, 50-65 parts of cattail pollen charcoal and 70-100 parts of India madder root charcoal;

wherein, the weight ratio of the group A, the group B, the group C and the group D is 1: 1: 1: 1.

preferably, the traditional Chinese medicine formula for treating infantile epistaxis comprises the following raw materials in parts by weight:

group A: 60-70 parts of bletilla striata, 60-70 parts of scutellaria baicalensis, 30-40 parts of gentian, 20-30 parts of raw liquorice, 80-90 parts of fried lotus rhizome node and 80-90 parts of fried sophora flower;

group B: 90-100 parts of cogongrass rhizome, 55-60 parts of red peony root, 60-65 parts of tree peony bark, 55-60 parts of gardenia jasminoides, 120 parts of hairyvein agrimony, 130 parts of red sage herb and 70-80 parts of common clubmoss herb;

group C: 30-40 parts of Senecio cannabifolius less, 60-70 parts of Japanese thistle herb, 60-70 parts of white mulberry root-bark, 50-60 parts of carbonized human hair, 55-60 parts of cacumen biotae, 25-30 parts of rhubarb and 60-70 parts of dwarf lilyturf tuber;

group D: 55-60 parts of callicarpa bodinieri, 80-90 parts of clinopodium polycephalum, 55-60 parts of euphorbia hirta, 80-100 parts of charred schizonepeta, 55-60 parts of charred cattail pollen and 80-90 parts of charred madder;

group A: 65 parts of bletilla striata, 65 parts of scutellaria baicalensis, 35 parts of gentian, 26 parts of raw liquorice, 85 parts of fried lotus rhizome node and 85 parts of fried sophora flower;

group B: 95 parts of cogongrass rhizome, 58 parts of radix paeoniae rubra, 62 parts of cortex moutan radicis, 58 parts of gardenia jasminoides, 125 parts of agrimony and 75 parts of herba nonanthi;

group C: 35 parts of Senecio cannabifolius less, 66 parts of Japanese thistle herb, 65 parts of white mulberry root-bark, 55 parts of carbonized human hair, 57 parts of cacumen biotae, 28 parts of rhubarb and 66 parts of dwarf lilyturf tuber;

group D: 58 parts of callicarpa bodinieri, 85 parts of clinopodium polycephalum, 57 parts of euphorbia hirta, 90 parts of schizonepeta charcoal, 57 parts of cattail pollen charcoal and 85 parts of India madder root charcoal;

the second purpose of the invention is: provides a preparation method of a traditional Chinese medicine formula for treating infantile epistaxis.

a preparation method of a traditional Chinese medicine formula for treating infantile epistaxis comprises the following specific steps:

(1) weighing the raw materials according to the weight parts, uniformly mixing, and putting into a health preserving pot or a marmite for later use;

(2) adding water, soaking, decocting, and filtering to obtain filtrate.

Preferably, the amount of water added in step (2) is 5-8 times the weight of the raw materials.

Preferably, the amount of water added in step (2) is 6 times the weight of the raw materials.

Preferably, the soaking time in the step (2) is 3-5 h.

Preferably, the soaking time in step (2) is 4 h.

Preferably, the decocting time in the step (2) is 1-2 h.

Preferably, the decocting time in step (2) is 1.5 h.

The main effects of the raw materials used in the traditional Chinese medicine formula are as follows:

bletilla striata has the effects of astringing to stop bleeding, relieving swelling and promoting tissue regeneration; can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin; pulmonary tuberculosis hemoptysis, ulcer hemorrhage.

Scutellaria baicalensis: has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic materials, stopping bleeding, and preventing miscarriage; it can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, yellow gallbladder due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, threatened abortion, hypertension, carbuncle, furuncle, and sore.

Gentian: has the effects of clearing heat, eliminating dampness and purging liver and gallbladder fire; can be used for treating jaundice due to damp-heat pathogen, pudendal swelling, pudendal pruritus, eczema, pruritus, liver fire, conjunctival congestion, tinnitus, deafness, hypochondriac pain, bitter taste in mouth, middle-jiao strengthening, and convulsion.

Raw licorice root: benefiting qi and invigorating middle warmer; relieving spasm and pain; moistening lung to arrest cough; purging pathogenic fire and removing toxic substances; harmonizing the effects of the various drugs; mainly treats the symptoms of listlessness and poor appetite; emaciation and yellow face; palpitation and shortness of breath; abdominal pain and loose stool; limb spasm and pain; irritability; cough and asthma; swollen and sore throat; carbuncle sore and swelling pain; infantile carbuncle is caused.

Frying lotus rhizome nodes: has the effects of astringing to stop bleeding and removing blood stasis, and is mainly used for hematemesis, hemoptysis, epistaxis, hematuria and metrorrhagia and metrostaxis.

And (3) frying the sophora flower: has effects of clearing away heat and toxic materials, cooling blood, moistening lung, lowering blood pressure, and preventing apoplexy.

Cogongrass rhizome: has the effects of cooling blood, stopping bleeding, clearing heat and promoting urination; can be used for treating hematemesis due to blood heat, epistaxis, hematuria, fever polydipsia, cough due to lung heat, stomach heat emesis, jaundice due to damp-heat pathogen, edema oliguria, stranguria with astringency and pain due to heat.

Radix paeoniae rubra: has the effects of clearing heat, cooling blood, removing blood stasis and relieving pain; it can be used for treating amenorrhea due to stasis, hernia, abdominal mass, abdominal pain, hypochondriac pain, epistaxis, dysentery with bloody stool, hematochezia, conjunctival congestion, carbuncle, swelling, and traumatic injury.

Moutan bark: has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and relieving deficiency heat.

Yellow gardenia: has the effects of clearing heat, purging fire and cooling blood.

Agrimony: has effects in astringing, stopping bleeding, relieving inflammation, relieving dysentery, removing toxic materials, killing parasite, invigorating qi, and tonifying heart; can be used for treating hematemesis, hemoptysis, epistaxis, hematuria, functional metrorrhagia, dysentery, gastroenteritis, trichomonas vaginalis, fatigue, asthenia, and contusion of lumbago.

Nine-tower grass: has the effects of dispelling wind, clearing heat, removing toxic substance, relieving swelling, and stopping bleeding; can be used for treating common cold, sunstroke, hepatitis, dysentery, enteritis, and external hemorrhage.

Herba Senecionis Cannabifolii: has the effects of warming lung, descending qi, eliminating phlegm and relieving cough; it can be used for treating cough and asthma due to wind-cold evil, cough with purulent blood, pharyngitis, and dysuresia.

And (5) common cephalanoplos herb: has the effects of cooling blood, stopping bleeding, removing blood stasis and relieving swelling; it can be used for treating epistaxis, hematemesis, hematuria, hematochezia, metrorrhagia, metrostaxis, traumatic hemorrhage, carbuncle, swelling, and skin ulcer.

White mulberry root-bark: has the effects of purging the lung, relieving asthma, promoting diuresis and relieving swelling; it can be used for treating cough and asthma due to lung heat, oliguria, edema, and swelling of skin.

Carbonized human hair: has the effects of astringing to stop bleeding, removing blood stasis and promoting urination; it can be used for treating hematemesis, hemoptysis, epistaxis, stranguria with blood, hematuria, hematochezia, metrorrhagia, traumatic hemorrhage, and dysuria.

Cacumen biotae: has the effects of cooling blood, stopping bleeding, eliminating phlegm, relieving cough, growing hair and blackening hair; can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature gray hair.

Rhubarb: has effects in eliminating stagnation, clearing away heat and dampness, purging pathogenic fire, cooling blood, removing blood stasis, and removing toxic materials; it can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, intestinal carbuncle, abdominal pain, amenorrhea due to blood stasis, puerperal blood stasis, traumatic injury, dysentery due to damp-heat pathogen, jaundice, dark urine, stranguria, and edema.

And (3) dwarf lilyturf root: has the effects of nourishing yin, moistening lung, benefiting stomach, promoting fluid production, clearing heart fire and relieving restlessness; can be used for treating dry cough due to lung dryness, lung carbuncle, cough due to yin deficiency, thirst due to body fluid consumption, diabetes, vexation, insomnia, throat pain, constipation due to intestinal dryness, hematemesis, and epistaxis.

Callicarpa bodinieri: has effects in dispelling blood stasis, stopping bleeding, relieving inflammation and pain, and inhibiting bacteria; it is used to treat hematemesis, hemoptysis, and hematochezia.

Blood flow breaking: has the effects of astringing and stopping bleeding; it can be used for treating metrorrhagia, metrostaxis, hematuria, epistaxis, gingival hemorrhage, and traumatic hemorrhage.

Flying poplar grass: has the effects of clearing away heat and toxic materials, promoting diuresis and relieving swelling; mainly treats pulmonary abscess; acute mastitis; dysentery; diarrhea; hot spraying; hematuria; eczema; tinea pedis; itch of the skin; furuncle swelling toxin; ulcerative gingivitis; and (5) lack of milk after delivery.

Charring the fineleaf schizonepeta herb: has the effects of astringing and stopping bleeding; it can be used for treating hematochezia, metrorrhagia, and puerperal blood dizziness.

Charring pollen Typhae: has the effects of promoting blood circulation, removing blood stasis and stopping bleeding; can be used for treating liver cancer due to accumulation of toxic heat and blood stasis, pancreatic cancer, biliary tract tumor, skin ecchymosis, gingival hemorrhage, dark urine, and greasy tongue coating.

Charring radix rubiae: has the effects of cooling blood, stopping bleeding, promoting blood circulation, removing blood stasis, dispelling pathogenic wind, dredging collaterals, clearing heat, removing jaundice, relieving cough and eliminating phlegm; can be used for treating hematemesis, epistaxis, hematuria, hematochezia, metrorrhagia, amenorrhea, rheumatalgia, traumatic injury, blood stasis, swelling and pain, jaundice, and chronic tracheitis.

The invention has the beneficial effects that:

the invention follows the prescription and medicament principle of the traditional Chinese medicine, carries out dialectical compatibility and prescription, selects bletilla striata, fried lotus rhizome node, fried sophora flower, hairyvein agrimony, charred schizonepeta, carbonized hair, clinopodium polycephalum and charred madder as monarch medicaments, and has the efficacy of astringing and stopping bleeding; the radix scutellariae, the gentian, the gardenia jasminoides ellis, the Cirsium japonicum, the cacumen biotae, the radix ophiopogonis, the rheum officinale, the callicarpa bodinieri, the cortex mori radicis and the cattail pollen charcoal are selected as ministerial drugs, so that the effect of guiding fire downward is achieved; cogongrass rhizome, garden euphorbia herb, red peony root, tree peony bark and herba nonanthi praeparata are selected as adjuvant drugs, so that the effects of removing stasis and cooling blood are achieved; licorice root and Senecio cannabifolius less are used as guiding drugs to harmonize the other drugs. The traditional Chinese medicine composition provided by the invention fundamentally cures the frequent epistaxis of children by combining the monarch, minister, assistant and guide medicines, has no adverse reaction, side effect, no dependence, safety, reliability and difficult recurrence.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

Example 1

group A: 50 parts of bletilla striata, 50 parts of scutellaria baicalensis, 20 parts of gentian, 10 parts of raw liquorice, 70 parts of fried lotus rhizome node and 70 parts of fried sophora flower;

group B: 80 parts of cogongrass rhizome, 50 parts of radix paeoniae rubra, 50 parts of cortex moutan radicis, 50 parts of gardenia jasminoides, 110 parts of hairyvein agrimony and 60 parts of herba nonanthi;

group C: 20 parts of Senecio cannabifolius less, 50 parts of Japanese thistle herb, 50 parts of white mulberry root-bark, 40 parts of carbonized human hair, 50 parts of cacumen biotae, 20 parts of rhubarb and 50 parts of dwarf lilyturf tuber;

group D: 50 parts of callicarpa bodinieri, 70 parts of clinopodium polycephalum, 50 parts of euphorbia hirta, 70 parts of schizonepeta charcoal, 50 parts of cattail pollen charcoal and 70 parts of madder charcoal;

the preparation method of the traditional Chinese medicine formula for treating infantile epistaxis comprises the following specific steps:

(2) adding 5 times of water by weight, soaking for 3h, decocting for 1h, and filtering to obtain filtrate.

Example 2

group A: 80 parts of bletilla striata, 75 parts of scutellaria baicalensis, 50 parts of gentian, 30 parts of raw liquorice, 100 parts of fried lotus rhizome nodes and 100 parts of fried sophora japonica;

group B: 100 parts of cogongrass rhizome, 65 parts of radix paeoniae rubra, 65 parts of cortex moutan, 65 parts of gardenia jasminoides, 140 parts of hairyvein agrimony and 90 parts of herba nonanthi;

group C: 50 parts of Senecio cannabifolius less, 80 parts of Japanese thistle herb, 80 parts of white mulberry root-bark, 70 parts of carbonized human hair, 65 parts of cacumen biotae, 35 parts of rhubarb and 80 parts of dwarf lilyturf tuber;

group D: 65 parts of callicarpa bodinieri, 100 parts of clinopodium polycephalum, 65 parts of euphorbia hirta, 110 parts of schizonepeta charcoal, 65 parts of cattail pollen charcoal and 100 parts of India madder root charcoal;

(2) adding 6 times of water by weight, soaking for 4h, decocting for 1.5h, and filtering to obtain filtrate.

Example 3

group A: 60 parts of bletilla striata, 60 parts of scutellaria baicalensis, 30 parts of gentian, 20 parts of raw liquorice, 80 parts of fried lotus rhizome node and 80 parts of fried sophora flower;

group B: 90 parts of cogongrass rhizome, 55 parts of radix paeoniae rubra, 60 parts of cortex moutan, 55 parts of gardenia jasminoides, 120 parts of hairyvein agrimony and 70 parts of herba nonanthi;

group C: 30 parts of Senecio cannabifolius less, 60 parts of Japanese thistle herb, 60 parts of white mulberry root-bark, 50 parts of carbonized human hair, 55 parts of cacumen biotae, 25 parts of rhubarb and 60 parts of dwarf lilyturf tuber;

group D: 55 parts of callicarpa bodinieri, 80 parts of clinopodium polycephalum, 55 parts of euphorbia hirta, 80 parts of carbonized schizonepeta, 55 parts of carbonized cattail pollen and 80 parts of carbonized madder;

(2) adding 8 times of water by weight, soaking for 5h, decocting for 2h, and filtering to obtain filtrate.

Example 4

group A: 70 parts of bletilla striata, 70 parts of scutellaria baicalensis, 40 parts of gentian, 30 parts of raw liquorice, 90 parts of fried lotus rhizome nodes and 90 parts of fried sophora japonica;

group B: 100 parts of cogongrass rhizome, 60 parts of radix paeoniae rubra, 65 parts of cortex moutan, 60 parts of gardenia jasminoides, 130 parts of hairyvein agrimony and 80 parts of herba nonanthi;

group C: 40 parts of Senecio cannabifolius less, 70 parts of Japanese thistle herb, 70 parts of white mulberry root-bark, 60 parts of carbonized human hair, 60 parts of cacumen biotae, 30 parts of rhubarb and 70 parts of dwarf lilyturf tuber;

group D: 60 parts of callicarpa bodinieri, 90 parts of clinopodium polycephalum, 60 parts of euphorbia hirta, 100 parts of schizonepeta charcoal, 60 parts of cattail pollen charcoal and 90 parts of India madder root charcoal;

(2) adding 7 times of water by weight, soaking for 5h, decocting for 2h, and filtering to obtain filtrate.

Example 5

And (3) clinical observation statistics:

1. observing an object:

the treated group and the control group have 100 cases respectively, and the age is between 2 and 10 years.

2. Method of treatment

Treatment groups: the medicine is taken three times a day after waiting for warm, 100mL is taken once, one treatment course is one week, and two to four weeks are used continuously.

Control group: hemostasis with chlorphenamine is adopted for bleeding.

3. Using recurrence time as therapeutic effect criterion

And (3) curing: the disease does not relapse within 1 year after hemostasis.

The method has the following advantages: the disease does not relapse within the second half year of hemostasis but relapses within 6-12 months.

And (4) invalidation: recurrence within half a year of hemostasis.

4. Results

The results are shown in table 1 below:

TABLE 1 therapeutic effect comparison table

Item	Cure of disease	Is effective	Invalidation
				Treatment group	83 people	11 persons	6 persons
Control group	58 persons	17 persons	25 persons

As can be seen from table 1: in 100 cases of the treatment group taking the medicine, 83 patients are cured, 11 patients are effective, and 6 patients are ineffective, the cure rate is 83%, and the total effective rate is 94%; in the control group, 58 patients are cured, 17 patients are effective, and 25 patients are not effective, the cure rate is 58%, and the total effective rate is 75%.

From the above data it can be seen that: when the method is adopted to treat the nasal bleeding with unknown reasons, the recurrence condition is obviously better than the haemostasis.

Examples of typical cases are:

case 1

The Chinese medicinal formula disclosed by the invention has the advantages that the patient can be cured after two treatment courses of treatment, the clinical symptoms completely disappear, and the disease does not relapse after one follow-up visit.

Case 2

Zhangxxx, female, 4 years old, school of kindergarten reading, 2016 for 5 months, in the school of activities outside class, collision with other children on duty, and fall down to cause epistaxis, the amount of bleeding is above 100ml, the infant is delivered to our place urgently, the traditional Chinese medicine is taken to be decocted and drenched, the epistaxis stops after one hour, and parents take three doses of traditional Chinese medicine advice to feed the infant at irregular time, so as to consolidate the treatment. After half a year follow-up, no recurrence occurs.

Case 3

Liao xxx, male, 6 years old, preschool scholars in kindergarten, from 3 years old, epistaxis in irregular time in day and night, parents of the students spend much on epistaxis treatment, and the epistaxis can not be cured radically by hospitalization and folk treatment.

Claims

1. A traditional Chinese medicine formula for treating infantile epistaxis is characterized in that: the feed comprises the following raw materials in parts by weight:

2. the traditional Chinese medicine formula for treating epistaxis in children according to claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight:

3. the traditional Chinese medicine formula for treating epistaxis in children according to claim 2, which is characterized in that: the feed comprises the following raw materials in parts by weight:

4. a method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to any one of claims 1 to 3, which is characterized by comprising the following steps: the method comprises the following specific steps:

(2) adding water, soaking, decocting, and filtering to obtain filtrate.

5. The method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to claim 4, which is characterized in that: the water adding amount in the step (2) is 5-8 times of the weight of the raw materials.

6. The method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to claim 5, which is characterized in that: the water adding amount in the step (2) is 6 times of the weight of the raw materials.

7. The method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to claim 4, which is characterized in that: the soaking time in the step (2) is 3-5 h.

8. The method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to claim 7, which is characterized in that: the soaking time in the step (2) is 4 hours.

9. The method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to claim 4, which is characterized in that: the decoction time in the step (2) is 1-2 h.

10. The method for preparing a traditional Chinese medicine formula for treating epistaxis in children according to claim 9, which is characterized in that: the decoction time in the step (2) is 1.5 h.