CN113750188B

CN113750188B - Application of traditional Chinese medicine composition in preparation of medicine for treating cold

Info

Publication number: CN113750188B
Application number: CN202010503792.XA
Authority: CN
Inventors: 刘小军; 赵辉平; 苗倩倩; 肖雨晨; 刘欢; 朱露; 赵静; 王珑
Original assignee: Xi'an Xinrun Pharmaceutical Co ltd
Current assignee: Xi'an Xinrun Pharmaceutical Co ltd
Priority date: 2020-06-05
Filing date: 2020-06-05
Publication date: 2022-06-10
Anticipated expiration: 2040-06-05
Also published as: CN113750188A

Abstract

The invention discloses application of a traditional Chinese medicine composition in preparing a medicine for treating cold, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines: the traditional Chinese medicine composition not only further enhances the effects of defervescence, cough treatment and antivirus on the basis of clearing away the lung-heat and relieving asthma of the original formula of ephedra, apricot kernel, gypsum, liquorice, polygonatum, bamboo leaves, reed rhizome, common andrographis herb, cyrtomium rhizome and blackberry lily, but also can effectively relieve acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis caused by cold. The traditional Chinese medicine composition has the advantages of simple and feasible preparation process, exact curative effect, quick response, no toxic or side effect and obvious treatment effect on viral cold and wind-heat type cold.

Description

Application of traditional Chinese medicine composition in preparation of medicine for treating cold

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating cold.

Background

The cold is a common disease and a frequently encountered disease in clinic, and 90 percent of the cold is caused by virus infection. In general, common cold due to wind-cold and wind-heat are common in clinic. Wind-heat type common cold is caused by the invasion of pathogenic wind-heat into the exterior and the disharmony of lung-qi. The symptoms are marked by fever, slight aversion to wind, distending pain in the head, sweating, red and swollen and painful throat, cough, sticky or yellow sputum, nasal obstruction, yellow nasal discharge, thirst with desire for drink, red tongue tip and edge, thin, white and yellowish fur. Wind-heat type common cold is mostly seen in summer and autumn, and the main treatment is to relieve exterior syndrome with pungent and cool natured drugs.

In clinical practice, a large number of western medicines are commonly used for treating cold, and various adverse reactions are easily caused when the western medicines are used for treating cold. Such as: ibuprofen, nimesulide and the like can cause drug-induced kidney damage; aspirin can cause adverse reactions such as rash, angioneurogenic edema and the like. Therefore, the research on the traditional Chinese medicine compound prescription which can improve or treat cold symptoms and has small adverse reaction becomes a hot spot in recent years in clinic. Aiming at wind-heat type common cold, the traditional Chinese medicine treatment aims at pungent and cool property, exterior syndrome penetrating, heat clearing and detoxifying. Pharmacological research in recent years proves that the traditional Chinese medicine can resist various viruses and bacteria.

According to the differentiation of traditional Chinese medicine, the viral cold is classified into wind-heat invading the wei, and is treated by dispelling wind and clearing heat, and the heat-toxin invasion is treated by clearing heat and removing toxicity. The heat-clearing and toxicity-removing methods are modified by taking Maxingshigan decoction as a basic prescription. However, since the viral cold is only treated by the ephedra, apricot and gypsum decoction, although the ephedra, apricot and gypsum decoction has the effects of cooling and ventilating, clearing away the lung-heat and relieving asthma, and is clinically used for treating cold, upper respiratory tract infection, acute bronchitis, pneumonia, bronchial asthma, measles complicated with pneumonia and other exterior syndromes, the ephedra, apricot and gypsum decoction is not completely satisfactory in curative effect when used alone for treating viral cold with heat evil obstructing lung and complicated acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis.

The traditional Chinese medicine composition aims to provide a traditional Chinese medicine composition which can effectively treat viral cold and wind-heat type cold by taking the ephedra, apricot, gypsum and licorice decoction as a basic prescription, further enhances the treatment of defervescence and cough and the antiviral action on the basis of clearing away the lung-heat and relieving asthma of the original basic prescription, and can effectively relieve acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis caused by cold.

Disclosure of Invention

Based on the above, the invention provides the traditional Chinese medicine composition for treating wind-heat type common cold and the preparation method thereof, wherein the traditional Chinese medicine composition has good curative effect and small side effect. The composition has simple and feasible preparation process, definite curative effect and no toxic or side effect.

The invention aims to provide application of a traditional Chinese medicine composition in preparation of a medicine for treating cold.

The invention also aims to provide a preparation method of an active ingredient of the traditional Chinese medicine composition in the preparation of medicines for treating cold.

The invention also aims to provide a preparation method of granules of the traditional Chinese medicine composition in the preparation of medicines for treating cold.

The invention also aims to provide a preparation method of the ointment for preparing the medicine for treating the cold.

In order to achieve the above purpose, the invention provides an application of a traditional Chinese medicine composition in preparing a medicine for treating cold, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

50-100 parts of fructus forsythiae, 20-60 parts of folium isatidis, 20-60 parts of honeysuckle, 10-40 parts of scutellaria baicalensis, 10-40 parts of ephedra, 5-20 parts of almond, 10-40 parts of gypsum, 50-100 parts of liquorice, 10-40 parts of polygonatum odoratum, 10-40 parts of bamboo leaves, 10-40 parts of reed rhizome, 10-40 parts of common andrographis herb, 20-60 parts of cyrtomium fortunei and 10-40 parts of blackberrykiky rhizome.

The traditional Chinese medicine composition of the invention preferably comprises the following components in parts by weight:

50 parts of fructus forsythiae, 60 parts of folium isatidis, 20 parts of honeysuckle, 40 parts of scutellaria baicalensis, 10 parts of ephedra, 20 parts of almond, 10 parts of gypsum, 100 parts of liquorice, 10 parts of polygonatum odoratum, 40 parts of bamboo leaves, 10 parts of reed rhizome, 40 parts of common andrographis herb, 20 parts of cyrtomium rhizome and 40 parts of blackberrylily rhizome.

The traditional Chinese medicine composition provided by the invention also preferably comprises the following components in parts by weight:

100 parts of fructus forsythiae, 20 parts of folium isatidis, 60 parts of honeysuckle, 10 parts of scutellaria baicalensis, 40 parts of ephedra, 5 parts of almond, 40 parts of gypsum, 50 parts of liquorice, 40 parts of polygonatum odoratum, 10 parts of bamboo leaves, 40 parts of reed rhizome, 10 parts of common andrographis herb, 60 parts of cyrtomium rhizome and 10 parts of blackberrylily rhizome.

The traditional Chinese medicine composition of the invention also preferably comprises the following components in parts by weight:

60 parts of fructus forsythiae, 40 parts of folium isatidis, 40 parts of honeysuckle, 20 parts of scutellaria baicalensis, 20 parts of ephedra, 10 parts of almond, 20 parts of gypsum, 60 parts of liquorice, 20 parts of polygonatum odoratum, 20 parts of bamboo leaves, 10 parts of reed rhizome, 20 parts of common andrographis herb, 40 parts of cyrtomium rhizome and 20 parts of blackberrykiky rhizome.

50 parts of fructus forsythiae, 30 parts of folium isatidis, 20 parts of honeysuckle, 20 parts of scutellaria baicalensis, 30 parts of ephedra, 20 parts of almond, 30 parts of gypsum, 80 parts of liquorice, 30 parts of polygonatum odoratum, 30 parts of bamboo leaves, 20 parts of reed rhizome, 30 parts of common andrographis herb, 50 parts of cyrtomium rhizome and 40 parts of blackberrykiky rhizome.

80 parts of fructus forsythiae, 20 parts of folium isatidis, 30 parts of honeysuckle, 30 parts of scutellaria baicalensis, 40 parts of ephedra, 20 parts of almond, 40 parts of gypsum, 100 parts of liquorice, 40 parts of polygonatum odoratum, 40 parts of bamboo leaves, 30 parts of rhizoma phragmitis, 40 parts of common andrographis herb, 30 parts of cyrtomium rhizome and 30 parts of blackberrykiky rhizome.

63 parts of fructus forsythiae, 42 parts of folium isatidis, 42 parts of honeysuckle, 21 parts of scutellaria baicalensis, 21 parts of ephedra, 10.5 parts of almond, 21 parts of gypsum, 63 parts of liquorice, 21 parts of polygonatum odoratum, 21 parts of bamboo leaves, 21 parts of rhizoma phragmitis, 21 parts of common andrographis herb, 42 parts of cyrtomium rhizome and 21 parts of blackberrykiky rhizome.

The traditional Chinese medicine composition is prepared from the following raw material medicines: fructus forsythiae, folium isatidis, honeysuckle, scutellaria baicalensis, ephedra, almond, gypsum, liquorice, polygonatum odoratum, bamboo leaves, rhizoma phragmitis, common andrographis herb, cyrtomium rhizome and blackberry lily, has the effects of pungent and cool catharsis, lung clearing and asthma relieving and antiviral effects, and can also relieve acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis caused by cold. Experimental verification shows that the traditional Chinese medicine composition has a remarkable curative effect on the cold. The traditional Chinese medicine composition can be replaced by traditional Chinese medicines with the same or similar functions.

The active ingredients of the traditional Chinese medicine composition are prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding clear water 6-12 times of the weight of the medicinal materials, decocting for 1-3 times, each for 0.5-3 hr;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.1-1.30, and measuring at 60-80 deg.C.

The thick paste obtained in the step (2) forms the active ingredient of the traditional Chinese medicine composition.

The Chinese medicinal composition is in the form of capsule, granule, unguent, powder, tablet, pill, or syrup.

In order to make the above dosage forms possible, it is necessary to add pharmaceutically acceptable auxiliary materials, such as: fillers, disintegrants, sweeteners, preservatives, bases, and the like.

The granules are prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 6-12 times of clear water, decocting for 1-3 times, each time for 1-3 hr;

(3) Mixing the soft extract of step (2) with adjuvants, wet granulating, oven drying at 50-95 deg.C, sieving with 10-24 mesh sieve, grading, and packaging.

The paste is prepared by the following steps:

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.20-1.25 at a temperature of 60-80 deg.C.

The preparation method of the other dosage forms of the granules and the paste of the invention comprises the following steps: weighing the raw materials according to the proportion, and preparing by adopting a conventional preparation method.

Detailed Description

The traditional Chinese medicine composition for treating cold provided by the invention has the following effects of the raw material medicines:

fructus forsythiae: bitter and slightly cold in taste. It enters lung, heart and small intestine meridians. Clear heat and remove toxicity, resolve swelling and dissipate nodulation. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, coma, macula, and stranguria with heat.

Folium isatidis: bitter and cold in flavor. It enters heart and stomach meridians. Clear heat and remove toxicity, cool blood and remove macula. Can be used for treating warm pathogen entering nutrient, hyperpyrexia, coma, speckle, eruption, jaundice, dysentery with heat, mumps, pharyngitis, erysipelas, and carbuncle.

Honeysuckle flower: sweet and cold in flavor. It enters lung, heart and stomach meridians. Clear heat and remove toxicity, cool and disperse wind-heat. Can be used for treating carbuncle, furuncle, sore throat, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever.

Scutellaria baicalensis: bitter and cold in flavor. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Herba ephedrae: pungent, slightly bitter and warm in flavor. It enters lung and bladder meridians. Induce sweating and dispel cold, ventilate lung and relieve dyspnea, induce diuresis to alleviate edema. Can be used for treating common cold due to wind-cold, chest distress, cough, and edema; bronchial asthma. Honey Chinese ephedra can moisten lung and relieve cough. It is often indicated for exterior syndrome, asthma and cough.

Almond: bitter taste, warm and toxic. Enter lung and large intestine meridians. Dispel phlegm and relieve cough, relieve dyspnea, moisten intestines. It is indicated for cough due to exogenous pathogenic factor, dyspnea, throat impediment, constipation due to intestinal dryness.

Gypsum: sweet, pungent and cold in flavor. It enters lung and stomach meridians. Clear heat and purge fire, relieve restlessness and quench thirst. Can be used for treating fever due to exogenous pathogens, hyperpyrexia, polydipsia, cough and asthma due to lung heat, excessive stomach fire, headache, and toothache.

Licorice root: sweet and mild in taste. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Bamboo leaf: sweet and bland in flavor and cold in nature. Enter heart, lung, gallbladder and stomach meridians. Clear heat and relieve restlessness, promote the production of body fluid and induce diuresis. It is indicated for fever with polydipsia, infantile convulsions and epilepsy, cough, reversed flow, hematemesis, flushed face, short urine, aphtha, tongue sore.

Fragrant solomonseal rhizome: sweet in flavor and slightly cold in nature. It enters lung and stomach meridians. To nourish yin, moisten dryness, promote the production of body fluid and quench thirst. Can be used for treating yin injury of lung and stomach, cough due to dryness-heat, dry throat, thirst, and diabetes due to internal heat.

Reed rhizome: sweet and cold in flavor. It enters lung and stomach meridians. Clear heat and promote fluid production, relieve restlessness, stop vomiting and induce diuresis. It can be used for treating febrile polydipsia, stomach heat emesis, cough due to lung heat, lung abscess with purulence, and pyretic stranguria with astringency and pain.

Andrographis paniculata: bitter and cold in flavor. It enters heart, lung, large intestine and bladder meridians. Clear heat and remove toxicity, cool blood and relieve swelling. Can be used for treating common cold, fever, sore throat, aphtha, cough, diarrhea, dysentery, stranguria, carbuncle, suppurative sore, and snake bite.

Rhizoma Osmundae: bitter taste and cool. Enter liver and stomach meridians. To kill ascaris, tapeworm and pinworm, clear heat, remove toxicity, cool blood and stop bleeding. It is used to treat wind-heat type common cold. Warm heat macula, hematemesis, epistaxis, intestinal wind, hematochezia, bloody dysentery, metrorrhagia, leukorrhagia, pyocutaneous disease, hematuria, menorrhagia, knife wound hemorrhage, ascarid, parasitosis, artificial abortion, and postpartum hemorrhage.

Shooting: bitter and cold in flavor. It enters lung meridian. Clear heat and remove toxicity, dissolve phlegm and relieve sore throat. Can be used for treating stagnation of heat-toxin and phlegm-fire, sore throat, excessive phlegm and saliva, cough and asthma.

The traditional Chinese medicine differentiation of viral influenza is that wind-heat invading the wei is suitable for dispelling wind and clearing heat, and heat toxin invasion is suitable for heat-clearing and detoxifying method, and the heat-clearing and detoxifying method is modified by taking Maxingshigan decoction as a basic prescription. The traditional Chinese medicine composition is prepared from fructus forsythiae, folium isatidis, honeysuckle, scutellaria baicalensis, polygonatum odoratum, bamboo leaves, rhizoma phragmitis, common andrographis herb, cyrtomium rhizome and blackberry lily and is matched with Maxingshigan decoction, wherein fructus forsythiae is a monarch drug in the formula and has the effects of clearing away heat and toxic materials, relieving swelling and dissipating stagnation; the folium isatidis, the common andrographis herb and the blackberry lily are ministerial medicines, and the effects of clearing heat and removing toxicity, cooling blood, reducing swelling, dissolving phlegm, relieving sore throat, assisting monarch medicines in clearing heat and removing toxicity, reducing swelling and resolving masses can be effectively enhanced and relieved; honeysuckle, bamboo leaves, polygonatum, reed rhizome, scutellaria, common andrographis herb, cyrtomium rhizome, ephedra, almond and gypsum are used as adjuvant drugs in the prescription, the prescription has the functions of clearing heat, eliminating dampness, detoxifying, relieving cough, nourishing yin, promoting the secretion of saliva or body fluid, cooling and dispelling wind heat, the assistant monarch drug has the functions of clearing heat and detoxifying, the ministerial drug has the functions of relieving symptoms such as cold discomfort and the like, and detoxifying and resisting viruses; the licorice root, radix Glycyrrhizae Praeparata, acts as a guiding drug to coordinate the effects of the other drugs in the recipe. The compatibility of various medicines has the efficacies of clearing away pestilence and toxic material, and dispersing lung heat.

The decoction of ephedra, apricot, stone and licorice in the formula is used as a basic formula, has the efficacies of pungent and cool nature, dispersing and purging, clearing lung-heat and relieving asthma, and is mainly used for treating the symptoms of exogenous wind pathogen, pathogenic heat obstructing the lung. Clinically, the traditional Chinese medicine is usually used for treating cold, upper respiratory tract infection, acute bronchitis, pneumonia, bronchial asthma, measles complicated with pneumonia and other exterior syndromes, but for viral cold with heat obstructing lung and complicated acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis, the curative effect of the traditional Chinese medicine is not completely satisfactory. The invention provides a traditional Chinese medicine composition which takes the ephedra, apricot, gypsum and licorice decoction as a basic prescription, can effectively treat viral cold and wind-heat type cold, not only further enhances the treatment of defervescence and cough and antiviral action on the basis of clearing away the lung-heat and relieving asthma of the original basic prescription, but also can effectively relieve acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis caused by cold.

The invention takes the ephedra, apricot kernel, gypsum and licorice decoction as a basic prescription, and is matched with fructus forsythiae, folium isatidis, common andrographis herb and blackberry lily, which are bitter and cold, clear away heat and toxic material, cool blood, dissolve phlegm and relieve sore throat, thus being capable of effectively enhancing and relieving the symptoms of throat discomfort caused by cold;

the honeysuckle, the bamboo leaves, the polygonatum, the reed rhizome, the sweet and cold natured medicaments are added to the decoction, so that the decoction is capable of clearing away heat and toxic materials, nourishing yin, promoting the production of body fluid and cooling and dispelling wind heat, wherein the bamboo leaves and the polygonatum can enhance the immunity of a human body and can relieve the defect that the indigowoad leaf, the honeysuckle, the scutellaria and the blackberry lily are easy to damage yang qi, so that the coldness-relieving medicament is adjusted to be a clearing and tonifying formula, and is more beneficial to the recovery of physical functions after diseases;

the traditional Chinese medicine composition is matched with scutellaria baicalensis, common andrographis herb and cyrtomium rhizome, and has the effects of clearing heat, drying dampness, diminishing inflammation, detoxifying and resisting viruses, so that the antiviral effect is increased on the basis of clearing away the lung-heat and relieving asthma of the original formula, and meanwhile, the traditional Chinese medicine composition can relieve acute and chronic tonsillitis, acute and chronic pharyngolaryngitis and acute and chronic bronchitis caused by cold, and further enhances the treatment effect of the formula.

The Chinese herbal medicines are used together to play the effects of clearing pestilence, detoxifying and dispersing lung heat.

The following examples illustrate the preparation of the Chinese medicinal composition of the present invention, but are not intended to limit the scope of the invention in any way.

Example 1:

prescription 1:

50 parts of fructus forsythiae, 60 parts of folium isatidis, 20 parts of honeysuckle, 40 parts of scutellaria baicalensis, 10 parts of ephedra, 20 parts of almond, 10 parts of gypsum, 100 parts of liquorice, 10 parts of polygonatum odoratum, 40 parts of bamboo leaves, 10 parts of reed rhizome, 40 parts of common andrographis herb, 20 parts of cyrtomium rhizome and 40 parts of blackberrykiky rhizome.

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 6 times of clear water, and decocting for 1 time and 3 hr;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.1, and measuring at 60 deg.C;

Example 2:

prescription 2:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 12 times of clear water, decocting for 3 times, 1 hr for the first time, 2 hr for the second time, and 2.5 hr for the third time;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.30, and measuring temperature at 80 deg.C;

Example 3:

prescription 3:

The granules of the traditional Chinese medicine composition are prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding clear water 8 times of the weight of the medicinal materials, decocting for 2 times, 1 hr for the first time, and 1.5 hr for the second time;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.25, and measuring temperature at 70 deg.C;

(3) mixing the soft extract of step (2) with adjuvants, wet granulating, oven drying at 75 deg.C, sieving with a screen, grading, and packaging.

Example 4:

prescription 4: 50 parts of fructus forsythiae, 30 parts of folium isatidis, 20 parts of honeysuckle, 20 parts of scutellaria baicalensis, 30 parts of ephedra, 20 parts of almond, 30 parts of gypsum, 80 parts of liquorice, 30 parts of polygonatum odoratum, 30 parts of bamboo leaves, 20 parts of reed rhizome, 30 parts of common andrographis herb, 50 parts of cyrtomium rhizome and 40 parts of blackberrykiky rhizome.

The ointment of the traditional Chinese medicine composition is prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 10 times of clear water, decocting for 3 times, each for 1 hr;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.25, and measuring temperature at 75 deg.C.

Example 5:

prescription 5:

The granules of the medicine are prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 6 times of clear water, decocting for 1 time, each for 3 hr;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.1, and measuring temperature at 65 deg.C.

(3) Mixing the soft extract obtained in step (2) with adjuvants, wet granulating, oven drying at 95 deg.C, sieving with a screen, grading, and packaging.

Example 6:

prescription 6:

The granules of the medicine are prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 10 times of clear water, decocting for 2 times, each time for 2 hr;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.2, and measuring temperature at 60 deg.C.

(3) Mixing the soft extract of step (2) with adjuvants, wet granulating, oven drying at 50 deg.C, sieving with a screen, grading, and packaging.

In order to show the application of the traditional Chinese medicine composition, the traditional Chinese medicine composition paste and the traditional Chinese medicine composition granules in the medicine for treating cold, the invention carries out animal pharmacodynamics verification experiments. In the experiment, the cold medicine prepared in the traditional Chinese medicine composition of the invention in the examples 3, 4 and 5 is applied, and the pharmacodynamic action and the treatment effect of the medicine are as follows. Through pharmacodynamic experiments, experimental data and results of treatment effects on the rabbits with fever caused by endotoxin are shown in tables 1 to 3, and it can be proved that the cold medicines prepared in technical examples 3, 4 and 5 of the invention have significant treatment effects on fever and cough caused by wind-heat cold.

The pharmacodynamic study below shows that the cold medicine prepared in the invention 3, 4 and 5 has the curative effect of treating wind-heat type cold.

1. The specific experiment is as follows:

(1) the specific embodiment of the invention provides an antipyretic effect experiment and related data results for the endotoxin fever rabbits.

40 New Zealand rabbits are bred in pure form, and male rabbits are bred in 65-75% of rooms for 1 week for experiments.

And randomly dividing the test sample into 4 groups, testing the normal body temperature for 3 times before the test, and testing the normal body temperature for 1 time at intervals of 15min, wherein the body temperature fluctuation of the test sample does not exceed 0.2 ℃ for the test.

③ the contrast group rabbit is drenched with distilled water of 10 ml/kg; experimental groups 1, 2 and 3 were administered with 4g/kg of the cold drug prepared in examples 3, 4 and 5, respectively, and after administration, each rabbit was administered with 250ng/kg (2500U/kg) of endotoxin injected into the ear vein, and the anal temperature was measured 1 time every 1 hour, and White Blood Cells (WBC) were counted by sampling blood from the ear vein every 2 hours, and the mean value and the standard deviation (″ X ± SD) were calculated and analyzed, and the results are shown in tables 1 and 2. P <0.05 compared to control group at each time point.

Table 1 shows the effect of cold drugs prepared in examples 3, 4, 5 on the body temperature of rabbits due to endotoxin ("× ± SD, n ═ 10), according to the data in table 1: after the control group of rabbits are injected with the vaccine for 0.5h, the body temperature begins to rise, reaches a peak after 3h, and then gradually falls. Compared with a control group, the cold medicines in the experimental groups 1, 2 and 3 can obviously reduce the temperature rise of the rabbits caused by endotoxin injection (P is less than 0.05); the temperature reduction effect of the experimental groups 1, 2 and 3 at 0.5 hour after the endotoxin injection is gradually presented, the body temperature of the rabbits of the experimental groups 1 and 2 at 2 hours after the endotoxin injection is obviously reduced, the difference is obvious (P is less than 0.05) compared with that of a control group, and the effect is continued until the test is finished at 6 hours after the endotoxin injection; the cooling effect of experimental group 3 at 3 hours after injection was significant (P <0.05), which effect continued until the end of the test at 6 hours after injection. The drugs in the experimental groups 1, 2 and 3 can obviously reduce the temperature rise of the rabbits caused by endotoxin, and the temperature reduction sequence is that the experimental group 1 > the experimental group 3 > the experimental group 2.

Table 1 example Effect of Cold drugs on Rabbit body temperature caused by endotoxin

n＝10)

Table 2 example Effect of Cold drugs on endotoxin-induced peripheral blood WBC in febrile rabbits (

n＝10)

P <0.05 compared to control at each time point.

Table 2 shows the effect of cold drugs prepared in examples 3, 4 and 5 on the endotoxin-induced peripheral blood WBC of febrile rabbits (″ X ± SD, n ═ 10) peripheral white blood cells of control rabbits decreased first and then increased, peripheral blood WBC decreased significantly 2h after endotoxin injection, increased sharply at 4h, peaked at 6-8h, and decreased slightly at 10 h. Compared with the control group, the WBC in peripheral blood of experimental groups 1, 2 and 3 is also in a significantly reduced state 2h after endotoxin injection, and the body temperature begins to recover 4h after endotoxin injection and is slightly lower than that of the control group; the experimental groups 1, 2, 3 peaked in WBC in peripheral blood 6h after endotoxin injection, but remained lower than the control group, and then began to gradually decrease until 10h was significantly different from the control group (P < 0.05).

(2) Results of experiments and related data on the effects of embodiments of the invention on cough and asthma in animals.

The weight of a Kunming mouse is 18-20 g.

Dividing into 4 groups randomly, and irrigating 10ml/kg of normal saline into a control group; the experimental groups 1, 2 and 3 are respectively and correspondingly given 4g/kg of the cold drug prepared in the embodiment 1-3, after each group of mice are subjected to gastric lavage for 1 hour, the animals receive ammonia water aerosol stimulation to induce cough at different time, the spraying pressure is 200kps, half effective amount is sequentially obtained through a sequential method, whether the cough occurs or not is observed and recorded, and statistical analysis is carried out by using T test.

Table 3 the effect of cold-treating drugs on the cough caused by ammonia in the example (

n＝12)

Group of	Cough-inducing time (second)
		Control group	15.65±0.23
Experiment 1 group	24.67±1.46*
		Experiment 2 groups	25.13±0.23*
Experiment 3 groups	26.16±0.96*

P <0.05 compared to control.

Table 3 shows the effect of the cold drug in the examples on the cough of the ammonia water-induced cough mice ("X ± SD, n ═ 12), and the results show that the cough induction time of the control mice was 15.64 seconds. Compared with the control group, the experimental groups 1, 2 and 3 can obviously prolong the time of the ammonia water spray stimulation to induce cough to 24.67 seconds, 25.13 seconds and 26.16 seconds (P is less than 0.05). The cold-treating drugs in examples 1, 2 and 3 can obviously inhibit the effect of ammonia water on inducing the cough of mice.

The experiments show that the traditional Chinese medicine composition for treating cold can effectively reduce symptoms of fever, cough and the like of animals, and no obvious adverse phenomenon is observed in the experimental period, so that the traditional Chinese medicine composition for treating cold can quickly and effectively relieve symptoms of fever and cough of cold, and further cure cold.

The above description is only a preferred embodiment of the present invention, and for those skilled in the art, the present invention should not be limited by the description of the present invention, which should be interpreted as a limitation.

Claims

1. The application of a traditional Chinese medicine composition in preparing a medicine for treating cold is characterized in that the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

2. The application of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

3. The application of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

100 parts of fructus forsythiae, 20 parts of folium isatidis, 60 parts of honeysuckle, 10 parts of scutellaria baicalensis, 40 parts of ephedra, 5 parts of almond, 40 parts of gypsum, 50 parts of liquorice, 40 parts of polygonatum odoratum, 10 parts of bamboo leaves, 40 parts of reed rhizome, 10 parts of common andrographis herb, 60 parts of cyrtomium rhizome and 10 parts of blackberrykiky rhizome.

4. The application of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

5. The application of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

6. The application of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

80 parts of fructus forsythiae, 20 parts of folium isatidis, 30 parts of honeysuckle, 30 parts of scutellaria baicalensis, 40 parts of ephedra, 20 parts of almond, 40 parts of gypsum, 100 parts of liquorice, 40 parts of polygonatum odoratum, 40 parts of bamboo leaves, 30 parts of reed rhizome, 40 parts of common andrographis herb, 30 parts of cyrtomium rhizome and 30 parts of blackberrylily rhizome.

7. The application of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:

8. The use according to any one of claims 1 to 7, characterized in that the active ingredients of the traditional Chinese medicine composition are prepared by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 6-12 times of clear water, decocting for 1-3 times, each time for 0.5-3 hr to obtain extractive solution;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.1-1.30, and measuring at 60-80 deg.C;

9. Use according to any one of claims 1 to 7, characterized in that: the Chinese medicinal composition is in the form of capsule, granule, unguent, powder, tablet, pill, or syrup.

10. Use according to claim 9, characterized in that said granules are made by the following steps:

(1) weighing fructus forsythiae, folium Isatidis, flos Lonicerae, Scutellariae radix, herba Ephedrae, semen Armeniacae amarum, Gypsum Fibrosum, Glycyrrhrizae radix, rhizoma Polygonati Odorati, folium Bambusae, rhizoma Phragmitis, herba Andrographitis, rhizoma Osmundae and rhizoma Belamcandae according to weight ratio, placing in an extraction pot, adding 6-12 times of clear water, decocting for 1-3 times, each time for 1-3 hr to obtain extractive solution;

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.1-1.30 at 60-80 deg.C;

(3) mixing the soft extract of step (2) with adjuvants, wet granulating, oven drying at 50-95 deg.C, sieving with a screen, grading, and packaging.

11. Use according to claim 9, characterized in that said paste is made by the following steps:

(2) filtering the above extractive solutions, mixing filtrates, concentrating to obtain soft extract with relative density of 1.20-1.25, and measuring at 60-80 deg.C.