CN105079798A - Pharmaceutical composition for treating syndrome of retention of lung phlegm-heat in infants and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating syndrome of retention of lung phlegm-heat in infants and preparation method of pharmaceutical composition Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating syndrome of retention of lung phlegm-heat in infants and a preparation method of the pharmaceutical composition, and belongs to the technical field of medicine, wherein the pharmaceutical composition is mainly prepared from the following Western and traditional Chinese medicinal ingredients: protease K, glycine, tannic acid, magnesium chloride, gamma-polyglutamic acid, sodium benzoate, menthol, taurine, eriophorum comosum nees, herb of Indian zehneria, millingtonia, fermented Chinese gall herb and tea leaves, puberulous glochidion root, dracontium foetidum, spongetree bark, juice of towel gourd, flaccid ulothrix algae, tomentose machilus leaf or root, liquorice root, rock cotoneaster leaf or root, diversifolious patrinia root, common fordia root or leaf, asarum geophilum hemsl., common cultivatea mushroom, schoenoplectus mucronatus and flower of chu-lan tree. The pharmaceutical composition for treating syndrome of retention of lung phlegm-heat in infants disclosed by the invention is rigorous prescription and reasonable in combination, and the pharmaceutical composition has functions of clearing away heat and dispersing lung, preventing phlegm from forming and stopping coughing, relieving sore throat and preventing asthma, promoting blood circulation and removing stasis, eliminating heat and relieving dysphoria; the pharmaceutical composition is concrete in curative effect, and in addition, the pharmaceutical composition is capable of enhancing pediatric immunity and accelerating rehabilitation; and the pharmaceutical composition is mild in efficacy, free from side effect and safe in use.
Description
Technical field
The present invention relates to medicine and pharmacology technical field, specifically relate to a kind of pharmaceutical composition and preparation method thereof for the treatment of children's's accumulation of phlegm-heat in the lung card.
Background technology
The common what children's of dyspnea and cough due to obstruction of lung-QI, the traditional Chinese medical science thinks that exopathogen stops up resistance what lung, and lung qi closing are not declared and caused, and its basic sign is characterized as and occurs heating, out of breath, cough, even flaring of nares, face is pale, the disease of lip cyanosis etc.The traditional Chinese medical science thinks that dyspnea and cough due to obstruction of lung-QI has because of the exterior tightened by pathogenic windcold, or the lung invaded by wind-warm, also to have to rise because of internal hyperactivity of cardiopyrexiat.
Wherein, what internal hyperactivity of cardiopyrexiat caused is called phlegm-heat closed lung, and be that exopathogen violates lung, strongly fragrant and heat-transformation, thermal burn lung Tianjin, refining liquid becomes expectorant, or has retained phlegm, feels wind heat again and occurs expectorant and accumulation of heat, is the general title of the clinical manifestation of stopping up resistance lung network.Cardinal symptom is: high fever is irritated, wheezing sound in the throat, yellowish thick sputum, and tachypnea is breathed heavily and suppressed, flaring of nares, or cyanotic lips, red tongue, yellow and greasy fur, slippery and rapid pulse, seriously can cause to breathe heavily to suppress seriously, dyspnea.Control suitable reducing heat and dispersing lung-QI, eliminating phlegm to relieve asthma.
But, for children's, have a delicate constitution, the medicine that side effect is too large should not be taken, therefore, consider Chinese medicine and western medicine to be carried out combination to treat children's's accumulation of phlegm-heat in the lung card.
Summary of the invention
First technical problem that the present invention solves is, provide a kind of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card, determined curative effect, is free from side effects, and solves the defect that prior art exists.
Second technical problem that the present invention solves is to provide a kind of preparation method for the treatment of the pharmaceutical composition of children's's accumulation of phlegm-heat in the lung card.
For solving above-mentioned first technical problem, the technical solution adopted in the present invention is:
A kind of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 0.2 ~ 3 part of E.C. 3.4.21.64, 0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine, 8 ~ 40 parts of rock shuttles (flower), 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower.
Improve as one, described a kind of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 0.2 ~ 3 part of E.C. 3.4.21.64, 0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine, 8 ~ 40 parts of rock shuttles (flower), 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower, 3 ~ 10 parts of Herba Ainsliaeae Glabrae, 1 ~ 3 part of new Rhizoma et radix valerianae, 2 ~ 20 portions of Aeschna melanicteras.
Wherein, menthol is for oral administration can be used as carminative, pharmaceutically for headache and nose, swallows, laryngitis etc., directly to respiratory mucus cell generation effect, increase the secretion of respiratory mucus, the mucus of thickness is diluted, reduce secretions proportion, reduce the frothy sputum of respiratory tract, effective ventilation tract is increased, have obvious alleviation to the lung that closes that expectorant heat causes.Taurine has antipyretic and antiinflammatory action, can reduce body temperature, is improved cellular immunization phagocytic function, the generation of Promote immunity globulin, improves immunity.Rock shuttle (flower): [nature and flavor] are pungent, temperature.[function cures mainly] flower: antiasthmatic-antitussive.Control and breath with cough.Horse hail: [nature and flavor] sweet in the mouth; Bitter; [return through] cool in nature lung; Liver; Spleen channel [function cures mainly] heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds; To reduce phlegm diuresis.Main carbuncle furuncle swells; Sucutaneous nodule scrofula; Laryngopharynx swelling and pain; Mumps; Stranguria caused by urinary stone; Dysuria; Skin eczema; Conjunctival congestion jaundice; Hemorrhoid complicated by anal fistula; Proctoptosis; Traumatic hemorrhage; Venom.Cortex Millingtoniae Hortensis: [nature and flavor] " choosing of Simao, Yunnan Chinese herbal medicine ": cool in nature, bitter in the mouth.[function cures mainly] " choosing of Simao, Yunnan Chinese herbal medicine ": except wind is antipruritic, anthelmintic is detoxified, eliminating phlegm and stopping cough.Control urticaria, eczema and various skin allergy, ascarid, cough phlegm dyspnea.Mass Galla chinesis et camelliae Fermentata: [nature and flavor] acid; Puckery; Micro-sweet; Flat [return through] heart; Lung; Stomach is through [function cures mainly] moistening the lung and resolving phlegm; Hemostasis antidiarrheal; Antipyreticly to promote the production of body fluid.Main chronic cough due to asthenia of viscera; Pharyngalgia; Aphtha; Ulcerative gingivitis; Have blood in stool; Dysentery; Have loose bowels; Proctoptosis; Summer-heat is thirsty.Radix glochidionis puberi: [nature and flavor] bitter in the mouth; Cool in nature; Mild toxicity [function cures mainly] clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication." vegetation is side just ": " removing food stagnancy, removing toxic substances, loose infections core, controls toothache, lumbago for clearing away lung-heat, throat." " Guizhou folk medicine ": " tonify deficiency, controls impairment caused by overstrain, cough-relieving, regulating menstruation, dysentery relieving.Abies nephrolepis: [nature and flavor] acrid in the mouth; Bitter; [function cures mainly] cool in nature induces sweat cough-relieving; Resolving phlegm and relieving asthma.Main fever and headache; Cough and asthma caused by tracheitis.Cortex acaciae farnesianae: [nature and flavor] acid; Puckery; Flat [return through] Liver Channel [function cures mainly] convergence, hemostasis, cough-relieving.It Luo Shui: [nature and flavor] sweet in the mouth; Micro-hardship; Cold nature [function cures mainly] " detailed outline is picked up any lost article from the road ": control two unilateral tonsillitis, again can expectorant fire, and removing toxic substances, clear interior-heat of holding concurrently, controls lung abscess, consumptive lung disease.Flaccid ulothrix algae: [nature and flavor] are salty; Cold [function cures mainly] clearing away heat and promoting diuresis; Preventing phlegm from forming and stopping coughing.Main edema; Cough expectorant knot.Fine hair hardwood nanmu: [nature and flavor] are bitter; Pungent; Cool [function cures mainly] preventing phlegm from forming and stopping coughing; Reducing swelling and alleviating pain; Hemostasis.Main cough with copious phlegm; Carbuncle furuncle swells; Fracture; Burn and scald; Traumatic hemorrhage.Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis): [nature and flavor] are sour, puckery; Cool [return through] lung; Liver Channel [function cures mainly] clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing, hemostasis and pain-relieving.Main dysentery, has loose bowels, stomachache, and cough is spitted blood, dysmenorrhea, leucorrhea.Water stone Brassica campestris L: [nature and flavor] are light; Micro-pungent; Be slightly cold [function cures mainly] heat-clearing and toxic substances removing; Preventing phlegm from forming and stopping coughing; Expelling wind and removing dampness; Stasis-dispelling and pain-killing.Radix Fordiae Cauliflorae (root, leaf): [nature and flavor] " Guangxi Chinese medicinal herbal ": sweet in the mouth is micro-pungent, property is put down, nontoxic.[function cures mainly] " register planted by Guangxi medicine ": root, leaf: cough-relieving, reduce phlegm, lung moistening, controls skin infection.Bulk watt: [nature and flavor] are pungent; Temperature [return through] lung; The heart; Liver; Kidney channel [function cures mainly] expelling wind and cold; Lung qi dispersing cough-relieving; Alleviating pain and detumescence.Main anemofrigid cold; Headache; Nasal sinusitis; Phlegm retention cough with asthma; Anemofrigid-damp arthralgia; Venom.Tricholoma mongolicum Imai: [nature and flavor] are sweet; Pungent; Property flat [return through] lung; Spleen; Stomach is through [function cures mainly] spleen invigorating tonify deficiency; Lung qi dispersing cough-relieving; Rash.Main dizziness is weak; God is tired indigestion and loss of appetite; Dyspepsia; Cough and asthma; Measles is not for can going out; Dysphoria.Water hair flower: [nature and flavor] bitter in the mouth; Pungent; [function cures mainly] cool in nature clearing away heat and expelling pathogen in the exterior; Lung qi dispersing cough-relieving.Main cold, fever; Cough.Flos Aglaiae Odoratae flower: [nature and flavor] are pungent; Sweet; Flat [function cures mainly] promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Lung qi dispersing cough-relieving.Main chest and diaphragm is full vexed; Dysphagic from the beginning of; Cold cough.Herba Ainsliaeae Glabrae: [nature and flavor] are sweet, cold.[function cures mainly] nourishing YIN and clearing away lung-heat, controls pulmonary tuberculosis cough and spits blood.New Rhizoma et radix valerianae: [nature and flavor] acrid in the mouth; Cool in nature; Poisonous [function cures mainly] blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain; Lung qi dispersing cough-relieving.Aeschna melanictera: [nature and flavor] 1. " not Lu ": " be slightly cold." 2. " Japan hanako materia medica ": " is cool, nontoxic." [function cures mainly] the kidney invigorating and essence nourishing, removing toxic substances, cough-relieving.Cure mainly impotence and seminal emission, throat swells and ache, pertussis etc.
For solving above-mentioned second technical problem, the technical solution adopted in the present invention is:
Treat a preparation method for the pharmaceutical composition of children's's accumulation of phlegm-heat in the lung card, comprise the following steps:
Step one: take 8 ~ 40 parts of rock shuttles (flower) by weight, 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower, mixing, steel mill is smashed and is less than the granule of 3mm to diameter, adds the water of 6 ~ 10 times of volumes, carries out ultrasonic extraction, extraction power is 300 ~ 600W, Extracting temperature is 65 ~ 75 DEG C, and extraction time is 40 ~ 50min, extracts 1 ~ 3 time altogether, extracting solution 600 ~ 650 mesh filter screen filters, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.02 ~ 1.24, and spraying dry makes extract powder, is 1 ~ 5% by filter residue and drying to moisture, be crushed to 300 orders, obtain filtering residue powder, getting with extract powder weight ratio is 1: the filtering residue powder of (0.2 ~ 0.3) and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: the Chinese medicine extract of above-mentioned steps one gained is mixed with 0.2 ~ 3 part of E.C. 3.4.21.64,0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine; obtain effective ingredient, require to be prepared into pharmaceutically conventional oral formulations according to pharmacy conventional pharmaceutical method and adjuvant.
Improve as one, described a kind of preparation method for the treatment of the pharmaceutical composition of children's's accumulation of phlegm-heat in the lung card, comprises the following steps:
Step one: take 8 ~ 40 parts of rock shuttles (flower) by weight, 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower, 3 ~ 10 parts of Herba Ainsliaeae Glabrae, 1 ~ 3 part of new Rhizoma et radix valerianae, 2 ~ 20 portions of Aeschna melanicteras, mixing, steel mill is smashed and is less than the granule of 3mm to diameter, adds the water of 6 ~ 10 times of volumes, carries out ultrasonic extraction, extraction power is 300 ~ 600W, Extracting temperature is 65 ~ 75 DEG C, and extraction time is 40 ~ 50min, extracts 1 ~ 3 time altogether, extracting solution 600 ~ 650 mesh filter screen filters, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.02 ~ 1.24, and spraying dry makes extract powder, is 1 ~ 5% by filter residue and drying to moisture, be crushed to 300 orders, obtain filtering residue powder, getting with extract powder weight ratio is 1: the filtering residue powder of (0.2 ~ 0.3) and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: the Chinese medicine extract of above-mentioned steps one gained is mixed with 0.2 ~ 3 part of E.C. 3.4.21.64,0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine; obtain effective ingredient, require to be prepared into pharmaceutically conventional oral formulations according to pharmacy conventional pharmaceutical method and adjuvant.
Further, described oral formulations comprises granule, tablet, hard capsule, soft capsule, oral liquid, pellet or other dosage forms.
Further, described adjuvant comprises: 5 ~ 20% binding agents, 0.1 ~ 0.6% wetting agent, 10 ~ 40% disintegrating agents, 0.2 ~ 0.5% lubricant, 0.2 ~ 0.3% correctives, and this percentage ratio is the percentage ratio that adjuvant accounts for medicine gross weight.
Further, described binding agent is starch slurry, polyvinylpyrrolidone or hydroxypropyl emthylcellulose; Described wetting agent is purified water or medicinal alcohol; Described disintegrating agent is pregelatinized Starch, microcrystalline Cellulose or carboxymethyl starch sodium; Described lubricant is Pulvis Talci, magnesium stearate, silicon dioxide or stearic acid; Described correctives is sucrose, cyclamate or enoxolone.
The invention has the beneficial effects as follows: the pharmaceutical composition choosing side that the present invention treats children's's accumulation of phlegm-heat in the lung card is rigorous, compatibility is reasonable, there is reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing, sore-throat relieving are relievingd asthma, blood circulation promoting and blood stasis dispelling, expel the heat-evil except hot-tempered effect, and determined curative effect, can also improve immunity in children, fast track rehabilitation, and drug effect is gentle, is free from side effects, use safety.
Detailed description of the invention
Embodiment 1:
A kind of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 0.2 part of E.C. 3.4.21.64, 0.5 part of glycine, 0.05 part of tannic acid, 0.1 part of magnesium chloride, 1.2 parts of gamma-polyglutamic acid-s, 0.5 part of sodium benzoate, 0.3 part of menthol, 0.8 part of taurine, 8 parts of rock shuttles (flower), 10 parts of horse hails, 8 parts of Cortex Millingtoniae Hortensiss, 6 parts of Mass Galla chinesis et camelliae Fermentata, 1 part of Radix glochidionis puberi, 9 portions of abies nephrolepis, 7 parts of Cortex acaciae farnesianaes, 5 parts of sky Luo Shui, 5 parts of flaccid ulothrix algaes, 8 parts of fine hair hardwood nanmus, 4 portions of Radix Glycyrrhizaes, 6 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 parts of water stone Brassica campestris Ls, 4 parts of Radix Fordiae Caulifloraes, 3 parts of bulks watt, 2 portions of Tricholoma mongolicum Imais, 1 part of water hair flower, 1 part of Flos Aglaiae Odoratae flower, 3 parts of Herba Ainsliaeae Glabrae, 1 part of new Rhizoma et radix valerianae, 2 portions of Aeschna melanicteras.
The preparation method of the pharmaceutical composition of this treatment children's accumulation of phlegm-heat in the lung card, comprises the following steps:
Step one: take 8 parts of Cortex Millingtoniae Hortensiss by weight, 6 parts of Mass Galla chinesis et camelliae Fermentata, 1 part of Radix glochidionis puberi, 9 portions of abies nephrolepis, 7 parts of Cortex acaciae farnesianaes, 5 parts of sky Luo Shui, 5 parts of flaccid ulothrix algaes, 8 parts of fine hair hardwood nanmus, 4 portions of Radix Glycyrrhizaes, 6 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 parts of water stone Brassica campestris Ls, 4 parts of Radix Fordiae Caulifloraes, 3 parts of bulks watt, 2 portions of Tricholoma mongolicum Imais, 1 part of water hair flower, 1 part of Flos Aglaiae Odoratae flower, 3 parts of Herba Ainsliaeae Glabrae, 1 part of new Rhizoma et radix valerianae, 2 portions of Aeschna melanicteras, mixing, steel mill is smashed to diameter and is less than the granule of 3mm, add the water of 6 times of volumes, carry out ultrasonic extraction, extraction power is 300W, Extracting temperature is 65 DEG C, extraction time is 40min, extract 1 time altogether, extracting solution 600 mesh filter screen filters, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.02, spraying dry makes extract powder, be 1% by filter residue and drying to moisture, be crushed to 300 orders, obtain filtering residue powder, get with extract powder weight ratio be 1: 0.2 filtering residue powder and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: by the Chinese medicine extract of above-mentioned steps one gained and 0.2 part of E.C. 3.4.21.64, 0.5 part of glycine, 0.05 part of tannic acid, 0.1 part of magnesium chloride, 1.2 parts of gamma-polyglutamic acid-s, 0.5 part of sodium benzoate, 0.3 part of menthol, 0.8 part of taurine mixing, obtain effective ingredient, require to be prepared into granule according to pharmacy conventional pharmaceutical method and adjuvant, tablet, hard capsule, soft capsule, oral liquid, pellet, described adjuvant comprises according to the percentage ratio accounting for medicine gross weight: 5% starch slurry, 0.1% purified water, 10% microcrystalline Cellulose, 0.2% Pulvis Talci, 0.2% sucrose.
Embodiment 2:
A kind of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 1.6 parts of E.C. 3.4.21.64s, 1.25 part glycine, 0.075 part of tannic acid, 0.3 part of magnesium chloride, 2.6 parts of gamma-polyglutamic acid-s, 1.75 part sodium benzoate, 0.75 part of menthol, 1.15 part taurine, 24 parts of rock shuttles (flower), 30 parts of horse hails, 24 parts of Cortex Millingtoniae Hortensiss, 18 parts of Mass Galla chinesis et camelliae Fermentata, 2 parts of Radix glochidionis puberis, 17 portions of abies nephrolepis, 13.6 part Cortex acaciae farnesianae, 22.5 parts of sky Luo Shui, 15 parts of flaccid ulothrix algaes, 21.5 parts of fine hair hardwood nanmus, 9.5 portions of Radix Glycyrrhizaes, 10.5 part Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis), 15.5 parts of water stone Brassica campestris Ls, 17 parts of Radix Fordiae Caulifloraes, 14 parts of bulks watt, 6 portions of Tricholoma mongolicum Imais, 10.5 parts of water hair flowers, 8 parts of Flos Aglaiae Odoratae flowers.
The preparation method of the pharmaceutical composition of this treatment children's accumulation of phlegm-heat in the lung card, comprises the following steps:
Step one: take 24 parts of rock shuttles (flower) by weight, 30 parts of horse hails, 24 parts of Cortex Millingtoniae Hortensiss, 18 parts of Mass Galla chinesis et camelliae Fermentata, 2 parts of Radix glochidionis puberis, 17 portions of abies nephrolepis, 13.6 part Cortex acaciae farnesianae, 22.5 parts of sky Luo Shui, 15 parts of flaccid ulothrix algaes, 21.5 parts of fine hair hardwood nanmus, 9.5 portions of Radix Glycyrrhizaes, 10.5 part Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis), 15.5 parts of water stone Brassica campestris Ls, 17 parts of Radix Fordiae Caulifloraes, 14 parts of bulks watt, 6 portions of Tricholoma mongolicum Imais, 10.5 parts of water hair flowers, 8 parts of Flos Aglaiae Odoratae flowers, mixing, steel mill is smashed to diameter and is less than the granule of 3mm, add the water of 8 times of volumes, carry out ultrasonic extraction, extraction power is 450W, Extracting temperature is 70 DEG C, extraction time is 45min, extract 2 times altogether, extracting solution 625 mesh filter screen filters, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.13, spraying dry makes extract powder, be 3% by filter residue and drying to moisture, be crushed to 300 orders, obtain filtering residue powder, get with extract powder weight ratio be 1: 0.25 filtering residue powder and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: by the Chinese medicine extract of above-mentioned steps one gained and 1.6 parts of E.C. 3.4.21.64s, 1.25 part glycine, 0.075 part of tannic acid, 0.3 part of magnesium chloride, 2.6 parts of gamma-polyglutamic acid-s, 1.75 part sodium benzoate, 0.75 part of menthol, 1.15 parts of taurine mixing, obtain effective ingredient, require to be prepared into granule according to pharmacy conventional pharmaceutical method and adjuvant, tablet, hard capsule, soft capsule, oral liquid, pellet, described adjuvant comprises according to the percentage ratio accounting for medicine gross weight: 12.5% polyvinylpyrrolidone, 0.35% purified water, 25% pregelatinized Starch, 0.35% magnesium stearate, 0.25% cyclamate.
Embodiment 3:
A kind of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 3 parts of E.C. 3.4.21.64s, 2 parts of glycine, 0.1 part of tannic acid, 0.5 part of magnesium chloride, 4 parts of gamma-polyglutamic acid-s, 3 parts of sodium benzoate, 1.2 parts of menthols, 1.5 parts of taurines, 40 parts of rock shuttles (flower), 50 parts of horse hails, 40 parts of Cortex Millingtoniae Hortensiss, 30 parts of Mass Galla chinesis et camelliae Fermentata, 3 parts of Radix glochidionis puberis, 25 portions of abies nephrolepis, 20 parts of Cortex acaciae farnesianaes, 40 parts of sky Luo Shui, 25 parts of flaccid ulothrix algaes, 35 parts of fine hair hardwood nanmus, 15 portions of Radix Glycyrrhizaes, 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 25 parts of water stone Brassica campestris Ls, 30 parts of Radix Fordiae Caulifloraes, 25 parts of bulks watt, 10 portions of Tricholoma mongolicum Imais, 20 parts of water hair flowers, 15 parts of Flos Aglaiae Odoratae flowers, 10 parts of Herba Ainsliaeae Glabrae, 3 parts of new Rhizoma et radix valerianaes, 20 portions of Aeschna melanicteras.
The preparation method of the pharmaceutical composition of this treatment children's accumulation of phlegm-heat in the lung card, comprises the following steps:
Step one: take 40 parts of rock shuttles (flower) by weight, 50 parts of horse hails, 40 parts of Cortex Millingtoniae Hortensiss, 30 parts of Mass Galla chinesis et camelliae Fermentata, 3 parts of Radix glochidionis puberis, 25 portions of abies nephrolepis, 20 parts of Cortex acaciae farnesianaes, 40 parts of sky Luo Shui, 25 parts of flaccid ulothrix algaes, 35 parts of fine hair hardwood nanmus, 15 portions of Radix Glycyrrhizaes, 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 25 parts of water stone Brassica campestris Ls, 30 parts of Radix Fordiae Caulifloraes, 25 parts of bulks watt, 10 portions of Tricholoma mongolicum Imais, 20 parts of water hair flowers, 15 parts of Flos Aglaiae Odoratae flowers, 10 parts of Herba Ainsliaeae Glabrae, 3 parts of new Rhizoma et radix valerianaes, 20 portions of Aeschna melanicteras, mixing, steel mill is smashed and is less than the granule of 3mm to diameter, adds the water of 10 times of volumes, carries out ultrasonic extraction, extraction power is 600W, Extracting temperature is 75 DEG C, and extraction time is 50min, extracts 3 times altogether, extracting solution 650 mesh filter screen filters, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.24, and spraying dry makes extract powder, is 5% by filter residue and drying to moisture, be crushed to 300 orders, obtain filtering residue powder, get with extract powder weight ratio be 1: 0.3 filtering residue powder and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: by the Chinese medicine extract of above-mentioned steps one gained and 3 parts of E.C. 3.4.21.64s, 2 parts of glycine, 0.1 part of tannic acid, 0.5 part of magnesium chloride, 4 parts of gamma-polyglutamic acid-s, 3 parts of sodium benzoate, 1.2 parts of menthols, 1.5 parts of taurine mixing, obtain effective ingredient, require to be prepared into granule according to pharmacy conventional pharmaceutical method and adjuvant, tablet, hard capsule, soft capsule, oral liquid, pellet, described adjuvant comprises according to the percentage ratio accounting for medicine gross weight: 5% hydroxypropyl emthylcellulose, 0.6% medicinal alcohol, 40% carboxymethyl starch sodium, 0.5% stearic acid, 0.3% enoxolone.
The pharmaceutical composition that the present invention treats children's's accumulation of phlegm-heat in the lung card has reducing heat and dispersing lung-QI, and preventing phlegm from forming and stopping coughing, sore-throat relieving are relievingd asthma, blood circulation promoting and blood stasis dispelling, expel the heat-evil except hot-tempered effect, determined curative effect, immunity in children can also be improved, fast track rehabilitation, and drug effect is gentle, be free from side effects, use safety.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. treat the pharmaceutical composition of children's's accumulation of phlegm-heat in the lung card for one kind, it is characterized in that, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 0.2 ~ 3 part of E.C. 3.4.21.64, 0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine, 8 ~ 40 parts of rock shuttles, 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower.
2. as claimed in claim 1 a kind of treat children's's accumulation of phlegm-heat in the lung card pharmaceutical composition, it is characterized in that, mainly formulated by the Chinese medicine and western medicine composition of following weight portion: 0.2 ~ 3 part of E.C. 3.4.21.64, 0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine, 8 ~ 40 parts of rock shuttles (flower), 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower, 3 ~ 10 parts of Herba Ainsliaeae Glabrae, 1 ~ 3 part of new Rhizoma et radix valerianae, 2 ~ 20 portions of Aeschna melanicteras.
3. a kind of preparation method of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card as claimed in claim 1, is characterized in that, comprise the following steps:
Step one: take 8 ~ 40 parts of rock shuttles by weight, 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower, mixing, steel mill is smashed and is less than the granule of 3mm to diameter, adds the water of 6 ~ 10 times of volumes, carries out ultrasonic extraction, extraction power is 300 ~ 600W, Extracting temperature is 65 ~ 75 DEG C, and extraction time is 40 ~ 50min, extracts 1 ~ 3 time, extracting liquid filtering, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.02 ~ 1.24, and spraying dry makes extract powder, by filter residue and drying, pulverize, obtain filtering residue powder, getting with extract powder weight ratio is 1: the filtering residue powder of (0.2 ~ 0.3) and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: the Chinese medicine extract of above-mentioned steps one gained is mixed with 0.2 ~ 3 part of E.C. 3.4.21.64,0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine; obtain effective ingredient, require to be prepared into pharmaceutically conventional oral formulations according to pharmacy conventional pharmaceutical method and adjuvant.
4. a kind of preparation method of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card as claimed in claim 2, is characterized in that, comprise the following steps:
Step one: take 8 ~ 40 parts of rock shuttles by weight, 10 ~ 50 parts of horse hails, 8 ~ 40 parts of Cortex Millingtoniae Hortensiss, 6 ~ 30 parts of Mass Galla chinesis et camelliae Fermentata, 1 ~ 3 part of Radix glochidionis puberi, 9 ~ 25 portions of abies nephrolepis, 7 ~ 20 parts of Cortex acaciae farnesianaes, 5 ~ 40 parts of sky Luo Shui, 5 ~ 25 parts of flaccid ulothrix algaes, 8 ~ 35 parts of fine hair hardwood nanmus, 4 ~ 15 portions of Radix Glycyrrhizaes, 6 ~ 15 parts of Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis)s, 6 ~ 25 parts of water stone Brassica campestris Ls, 4 ~ 30 parts of Radix Fordiae Caulifloraes, 3 ~ 25 parts of bulks watt, 2 ~ 10 portions of Tricholoma mongolicum Imais, 1 ~ 20 part of water hair flower, 1 ~ 15 part of Flos Aglaiae Odoratae flower, 3 ~ 10 parts of Herba Ainsliaeae Glabrae, 1 ~ 3 part of new Rhizoma et radix valerianae, 2 ~ 20 portions of Aeschna melanicteras, mixing, steel mill is smashed and is less than the granule of 3mm to diameter, adds the water of 6 ~ 10 times of volumes, carries out ultrasonic extraction, extraction power is 300 ~ 600W, Extracting temperature is 65 ~ 75 DEG C, and extraction time is 40 ~ 50min, extracts 1 ~ 3 time, extracting liquid filtering, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.02 ~ 1.24, and spraying dry makes extract powder, by filter residue and drying, pulverize, obtain filtering residue powder, getting with extract powder weight ratio is 1: the filtering residue powder of (0.2 ~ 0.3) and extract powder merge, mixing, obtain Chinese medicine extract, stand-by,
Step 2: the Chinese medicine extract of above-mentioned steps one gained is mixed with 0.2 ~ 3 part of E.C. 3.4.21.64,0.5 ~ 2 part of glycine, 0.05 ~ 0.1 part of tannic acid, 0.1 ~ 0.5 part of magnesium chloride, 1.2 ~ 4 parts of gamma-polyglutamic acid-s, 0.5 ~ 3 part of sodium benzoate, 0.3 ~ 1.2 part of menthol, 0.8 ~ 1.5 part of taurine; obtain effective ingredient, require to be prepared into pharmaceutically conventional oral formulations according to pharmacy conventional pharmaceutical method and adjuvant.
5. a kind of preparation method for the treatment of the pharmaceutical composition of children's's accumulation of phlegm-heat in the lung card as described in claim 3 to 4, it is characterized in that, described oral formulations comprises granule, tablet, hard capsule, soft capsule, oral liquid, pellet or other dosage forms.
6. a kind of preparation method of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card as claimed in claim 5, it is characterized in that, described adjuvant comprises: 5 ~ 20% binding agents, 0.1 ~ 0.6% wetting agent, 10 ~ 40% disintegrating agents, 0.2 ~ 0.5% lubricant, 0.2 ~ 0.3% correctives.
7. a kind of preparation method of pharmaceutical composition for the treatment of children's's accumulation of phlegm-heat in the lung card as claimed in claim 6, it is characterized in that, described binding agent is starch slurry, polyvinylpyrrolidone or hydroxypropyl emthylcellulose; Described wetting agent is purified water or medicinal alcohol; Described disintegrating agent is pregelatinized Starch, microcrystalline Cellulose or carboxymethyl starch sodium; Described lubricant is Pulvis Talci, magnesium stearate, silicon dioxide or stearic acid; Described correctives is sucrose, cyclamate or enoxolone.
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