CN115414451A - A topical Chinese medicinal composition for treating acne, and its preparation method - Google Patents

Abstract

The invention belongs to the technical field of skin care products, and particularly relates to an external traditional Chinese medicine composition for treating acne and a preparation method thereof, wherein the external traditional Chinese medicine composition comprises the following components in parts by weight: 10-20 parts of honeysuckle, 5-10 parts of scutellaria baicalensis, 5-10 parts of mung bean coat, 5-15 parts of semen cuscutae, 5-15 parts of rhizoma kaempferiae, 5-15 parts of salvia miltiorrhiza, 1-6 parts of selfheal, 5-10 parts of sophora flavescens and 1-5 parts of raw liquorice. (1) Weighing all the traditional Chinese medicines according to the formula proportion, cleaning and removing impurities and non-medicinal parts; (2) Adding 10 times of water into the above traditional Chinese medicines, decocting for 1 hr for 2 times, filtering, mixing decoctions, concentrating, centrifuging at 5000 rpm/min for 15 min, collecting the supernatant, adding into matrix, stirring at 275 rpm/min for 1 hr to obtain traditional Chinese medicine liquid, adding the traditional Chinese medicines into facial mask cloth, sealing, and sterilizing. The traditional Chinese medicine provided by the invention has the advantages of total effective rate of 91.67%, cure rate of 80-95%, definite clinical curative effect on acne, quick response, high safety, few side effects and improvement on the life quality of patients.

Description

A topical Chinese medicinal composition for treating acne, and its preparation method

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to an external traditional Chinese medicine composition for treating acne and a preparation method thereof.

Background

Acne vulgaris (Acne vulgaris) is a chronic inflammatory skin disease of hair follicles and sebaceous glands, and is clinically mainly characterized by Acne, papule, pustule, nodule and cyst, pigmentation can be left after the rash subsides, and permanent scars can be formed in serious people. Acne occurs to varying degrees throughout almost all lives, and it is estimated that 23.1 million people worldwide suffer from this disease. In china, the prevalence rate of acne vulgaris is about 8.1%, and the prevalence rate of acne vulgaris tends to increase year by year, and in recent years, more and more patients with acne in adolescence tend to be younger. Acne often occurs on the face, has certain damage and compatibility, affects physical and mental health and life quality of patients, and brings negative effects on learning, working, life and the like.

The causes of acne are complex, and the pathogenesis of acne is not completely elucidated at present. The pathogenesis of acne is mainly the following four factors: sebum secretion is exuberant, keratosis of hair follicles and sebaceous gland ducts is abnormal, and microorganisms such as propionibacterium acnes are colonized and inflammatory reaction is caused. Acne also occurs in association with a number of factors including immunity, genetic predisposition, sex hormone levels and psychological stress. At present, western medicine treatment of acne mainly aims at four major disease factors, and adopts drug treatment of retinoids, antibiotics, hormones and the like and physical treatment of red and blue light, laser, photodynamic and the like to reduce sebum secretion, inhibit hyperkeratosis, inhibit or kill propionibacterium acnes and resist inflammation. However, western medicines have limited indications for treating acne, long application course and large side effects after long-term application or improper use: such as teratogenicity of retinoids, drug resistance of antibiotics, gastrointestinal reactions and nine major side effects of hormones, and the like, and are easy to relapse.

Acne is the dominant disease species of traditional Chinese medicine. The traditional Chinese medicine has definite curative effect and high safety in treating acne, can improve general symptoms, improve life quality and reduce recurrence, so more and more acne patients select traditional Chinese medicine treatment. The traditional Chinese medicine for treating the acne vulgaris has unique characteristics, and mainly comprises an internal treatment method based on syndrome differentiation and treatment and a traditional Chinese medicine characteristic treatment method. Supplementary and alternative medicine such as traditional Chinese medicine, natural therapy, homeopathy and the like is increasingly popular with people of all countries all over the world. With the report standard of traditional Chinese medicine treatment (hCONSORT) promulgated abroad, a unified research report specification is provided for the traditional Chinese medicine research, and the development of the traditional Chinese medicine towards standardization and internationalization is promoted. In recent years, the traditional Chinese medicine for treating acne becomes a research hotspot, and the research and development of a more effective, safer and simpler treatment method is a consistent target and pursuit of all people researching acne. The traditional Chinese medicine is one of the characteristic therapies of the traditional Chinese medicine, takes the basic theory of the traditional Chinese medicine as guidance, applies different traditional Chinese medicines aiming at different diseases, and treats the facial diseases by directly contacting the facial skin with the traditional Chinese medicines. The effective components of the Chinese medicine can be absorbed through the skin, so that the potency of the Chinese medicine can directly enter skin and hair muscles and striae. The traditional Chinese medicine can increase the water content of the skin to help the medicine to be better absorbed, provide enough nutrient substances for the skin, improve local skin microcirculation and achieve the effects of dredging channels and collaterals, ventilating and activating blood, promoting blood circulation to remove blood stasis, and preventing senility and retaining youthfulness.

At present, a plurality of medicines for acne (pox) are available, but western medicines are limited in adaptation disease, long in application course, and large in side effect after long-term application or improper use: such as teratogenesis of retinoids, drug resistance of antibiotics, gastrointestinal reaction, and nine major side effects of hormones, and the like, and relapse is easy.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides an external traditional Chinese medicine composition for treating acne and a preparation method thereof.

In order to achieve the purpose, the technical scheme of the invention is as follows:

a traditional Chinese medicine composition for external use for treating acne comprises the following components in parts by weight: 10-20 parts of honeysuckle, 5-10 parts of scutellaria baicalensis, 5-10 parts of mung bean coat, 5-15 parts of semen cuscutae, 5-15 parts of rhizoma kaempferiae, 5-15 parts of salvia miltiorrhiza, 1-6 parts of selfheal, 5-10 parts of sophora flavescens and 1-5 parts of raw liquorice.

The invention also provides a preparation method of the external traditional Chinese medicine composition for treating acne, which comprises the following steps:

(1) Weighing the following components in proportion: flos Lonicerae, scutellariae radix, testa Phaseoli Radiati, semen Cuscutae, rhizoma Kaempferiae, saviae Miltiorrhizae radix, prunellae Spica, radix Sophorae Flavescentis, and Glycyrrhrizae radix; cleaning all the Chinese medicinal materials, and removing impurities and non-medicinal parts;

(2) Adding 10 times of water into the above traditional Chinese medicines, decocting for 1 hr for 2 times, filtering, mixing decoctions, concentrating, centrifuging at 5000 rpm/min for 15 min, collecting the supernatant, adding into matrix, stirring at 275 rpm/min for 1 hr to obtain traditional Chinese medicine liquid, adding the traditional Chinese medicines into facial mask cloth, sealing, and sterilizing.

Further, the base includes water, glycerin, methicone, PLGP/176 copolymer, cetostearyl alcohol, polysilsesquioxane, ethanol, panthenol, 1, 2-hexanediol, cetostearyl olive oleate, sorbitan olive oleate, hydroxyethyl cellulose, carbomer, glyceryl stearate/PEG-100 stearate, batyl alcohol, potassium hydroxide, acrylic/C10-30 alkanol acrylate crosspolymer, carnosine, irish rush oil, caprylyl hydroxamic acid, p-hydroxyacetophenone, melaleuca alternifolia oil, tocopherol (vitamin E).

The Chinese medicinal raw materials have the following medicinal properties and effects:

(1) Honeysuckle flower: sweet taste, cold nature, no toxicity, entering lung, heart and stomach meridians, and has the actions of clearing away heat and toxic material, dispelling wind and heat. It can be used for treating wind-heat type common cold, epidemic febrile disease, fever, toxic heat, dysentery, carbuncle, furuncle, erysipelas, and sore throat. In the records of raw herb property backup, honeysuckle can cure carbuncle, deep-rooted carbuncle, furuncle, dysentery, malnutritional ulcer and skin and blood heat without peel. Ben Cao gang mu (compendium of materia Medica) means that it can cure all damp, swelling, carbuncle, cellulitis, scabies and sores of waxberry. Dispel heat and remove toxicity ". Zhang Jingyue in Jingyue quan Shu (Jingyue complete book) mentions that honeysuckle flower is good at resolving toxin, so it is the essential herb for treating carbuncle-abscess, swelling toxin, sore and tinea, waxberry and rheumatism. It can disperse for those with no toxicity and disperse for those with toxicity. The book of Ben Jing Jie Yuan (the origin of the meridian) mentions that honeysuckle flower is a holy drug for removing toxicity, removing pus, tonifying diarrhea and ulceration. The honeysuckle is well recognized as a magical product for disinfection, has strong effect of disinfection, does not consume qi and blood, and can supplement qi and yin of people. It can be used in all stages of sores and ulcers: can relieve pain at the beginning; for pus-breaking, pus-removing; the closing-in can be started. Honeysuckle flower is sweet and cold in nature and fragrant in smell, can clear heat and remove toxicity, clear exterior and relieve heat and toxicity of blood system internally, and can also relieve swelling and dissipate stagnation, so that the honeysuckle flower is the key medicine for treating positive sores and ulcers and is known as a holy medicine for the patients with sores. The honeysuckle and dandelion, wild chrysanthemum flower, forsythia, chinese violet, cortex moutan, red peony root and liquorice can detoxify and cure sore, and the combination of the honeysuckle, dandelion, wild chrysanthemum flower, forsythia, chinese violet, cortex moutan, red peony root and liquorice can clear toxin and cure carbuncle. In the medical mind, it is mentioned that the honeysuckle decoction (four honeysuckle flowers and two, three liquorice roots and two liquorice roots are decocted in water for oral administration) can treat all internal and external carbuncle swellings.

(2) Scutellaria baicalensis: is bitter and cold in nature, enters large intestine, lung, spleen, gallbladder and small intestine channels, and has the effects of eliminating dampness, clearing heat, stopping bleeding, purging pathogenic fire, removing toxic substances, and preventing miscarriage. Can be used for treating dysentery, damp-warm syndrome, chest distress, emesis, summer-heat dampness, jaundice, cough due to lung heat, carbuncle, suppurative sore, hyperpyrexia, polydipsia, hematemesis, heat-damp distention, and threatened abortion. Recorded in the inspired medical science "Huang Qin is a herb for treating damp-heat in lung, swelling and red eyes due to heat, and blood stasis. Releasing the pathogenic fire from the lung and ascending the adverse flow of qi to the diaphragm, tonifying the cold-water deficiency of the bladder, and nourishing the origin of the transformation. Rihuazi Bencao said that it can lower qi and move heat, furuncle and discharge pus. For mammary abscess, manifested as dorsal swelling. The said "Benjing" (the book of treatises) carries the root of large-flowered skullcap to treat various types of fever jaundice, stranguria with bowel movement, diuresis, retention of the blood, malignant boil, deep-rooted carbuncle, erosion of fire and ulcer. Huang Qin excels in clearing damp-heat from middle energizer and treating abscess, swelling, sores and ulcers due to exuberant fire-toxin, and is often combined with jin Yin Hua, lian Qiao, huang Lian, huang Bai and Zhi Zi to reinforce the actions of clearing heat, removing toxicity, removing dampness and relieving swelling. Modern pharmacological researches find that the scutellaria has multiple effects of resisting bacteria, inflammation, tumors, fibrosis and fatigue, enhancing immunity, protecting heart and cerebral vessels, protecting nerve function, preventing and treating diabetes and the like. The scutellaria has a broad-spectrum antibacterial effect, has a stronger antibacterial effect than metronidazole, can obviously inhibit acne pathogenic bacteria such as propionibacterium acnes, has the effects of resisting inflammation, reducing sebaceous gland secretion, regulating immunity and the like, can act on each link of acne morbidity, and is commonly used for treating acne.

(3) Coating the mung bean: has sweet and cold nature and taste, and has effects of clearing away toxic materials and heat, and removing summer-heat. The traditional Chinese medicine composition is clinically used for treating diseases such as summer heat, polydipsia, mouth and tongue sores, carbuncle, swollen welling-abscess, rubella and erysipelas, food poisoning and drug poisoning and the like. In addition, mung bean can relieve the toxicity of Fu Zi and croton. The mung bean coating is sweet and cold in nature and has the effects of clearing away heat and toxic materials, relieving swelling, removing stasis and eliminating nebula. The book gang mu carries mung bean, the surgery of treating carbuncle-abscess and deep-rooted carbuncle has the effect of the heart-protecting powder with the inner support, and the Danxi Zhu Shi has the theory of playing. Green bean has the effects of clearing away heat and toxic materials, removing stone, arsenic and wood, and should be ground into powder with raw bark and taken with water. According to Yun in Yi Jian Zhi, some people take Fu Zi wine mostly, have swollen head like a bucket, have cracked lips and blood flow, and need to mix mung beans and black beans quickly, chew and decoct for drinking, and the action is also eliminated. Rihuazi materia Medica says that the traditional Chinese medicine can tonify qi, remove heat toxin and wind and thicken intestines and stomach; it can be used as pillow for improving eyesight and treating headache due to wind evil. In the book Ben Cao Hui Yan, it is said that the herbs can clear summer-heat, calm and vexe heat, moisten dryness-heat and remove toxic heat. Mung beans recorded in KAI BAO Ben Cao (Kai Bao materia Medica) are mainly used for treating erysipelas, dysphoria, rubella, hot gas rushing to dolphin and raw grinding and juicing. It is also decocted to relieve swelling and expel qi, and press heat and remove toxicity. The herb Zhenzhen is called as "good at removing toxicity", so it is not indicated for all abscess and swelling. It is said to be "clearing fire and clearing phlegm, treating carbuncle, swelling, pox and rot" from the meeting about doctor-mirror.

(4) And (3) semen cuscutae: the medicine has pungent and sweet taste and mild property, enters kidney, liver and spleen channels, and has the effects of tonifying liver and kidney, securing essence and reducing urination, preventing miscarriage, nourishing liver and improving eyesight and stopping diarrhea after being orally taken; it can be used externally for eliminating wind and acne, whitening skin, removing speckle, and caring skin. Clinically, it is commonly used for lumbago due to kidney deficiency, impotence, spermatorrhea, dribbling urination, enuresis, frequent micturition, diabetes, blurred vision, tinnitus, infertility due to cold womb, fetal movement due to kidney deficiency, and diarrhea due to spleen and kidney deficiency. The Shennong Bencao Jing mentions that dodder seed can' mainly make up for injury, tonify deficiency, tonify qi, strengthen body, remove blackish facial patch with juice, improve eyesight after long-term administration, lighten body and prolong life. The book Jing is called' continue injury, tonify deficiency, supplement qi, strengthen human body, and nourish, all of them have the meaning of dredging all vessels, warming and activating yang. The gum patch has effects of moistening skin. The Chinese pharmacology integration is called ' removing the face for a long time ' 198070707for pleasure in color '. In the formula of Fang Feng Fang from Ji backup Fang of elbow, cuscuta chinensis is pounded and squeezed to obtain juice for treating acne. For tinea and sore on eyebrow, it is indicated in the formula Wei Yao from shan Ju Si Yao. The Tu Si Zi Wan (Tu Si Zi is combined with Long Gu and Rong Lu) from Ji Sheng Fang can be used for treating premature senility of face and premature graying of beard and hair.

(5) And (3) rhizoma kaempferiae: pungent flavor and warm nature, entering stomach meridian, has the actions of moving qi, warming middle energizer, promoting digestion and alleviating pain. It is clinically used to treat fullness and distention of chest and diaphragm, cold pain in the abdomen, indigestion, toothache, swelling and pain from injuries and bone sticking. The Kaempferia galanga recorded in Pinghui Jing Yao can avoid foul smell; is applied to teeth as powder, and has the effects of dispelling pathogenic wind, relieving pain, and dispersing halitosis. The Lingnan Kangyao records that it can be used for treating injuries from falling, as well as swelling and choking on bones. For abdominal cold pain, it is combined with herbs of clove, dang Gui and gan Cao for clinical syndrome Zhong shan Kang; for bone sticking, radix Paeoniae Rubra and radix Clematidis are often combined; for toothache, it is ground into powder with musk, trilobine, nardostachys root, pricklyash peel and salt, and applied to teeth daily. Zhang Tianbo plus or minus Qufeng Ruan san (Kaempferia galangal, turmeric, mung bean, tuckahoe and stiff silkworm) is used for treating 110 cases of damp toxin and blood stasis type acne, and researches show that the total effective rate is 84.5 percent, the curative effect is exact and is obviously superior to that of a control group. Modern researches find that the kaempferia galanga has the following main pharmacological actions: anti-inflammatory, antiallergic, antioxidant, antibacterial, anti-infection, tranquilizing, anti-tumor, protecting tissue injury, and regulating blood sugar and blood lipid.

(6) Red sage root: bitter in nature and taste, slightly cold in nature, entering pericardium, heart and liver channels, non-toxic, having the functions of soothing nerves, relieving restlessness, cooling blood, removing carbuncle, dredging channels, activating blood circulation, removing blood stasis and relieving pain, and is commonly used for sore and ulcer gall, chest stuffiness and pain, irregular menstruation, amenorrhea and dysmenorrheal, abdominal mass and abdominal pain, abdominal mass and hypochondriac pain, heat stuffiness and pain, angina and vexation and insomnia. The book Ben Cao Qu Zhen records that all the symptoms such as arthralgia due to wind-cold, metrorrhagia, abdominal mass, conjunctival congestion, hernia pain, sore and scabies are always removed by stasis, so that the disease is not removed. In the book of the book, it is mentioned that the root of red-rooted salvia governs heart and abdomen pathogenic qi, and borborygmus may cause the accumulation of cold and heat; can relieve symptoms, remove obstruction in the abdomen, relieve restlessness and relieve fullness, and replenish qi. The compendium of materia medica is called as the formula of activating blood, dredging heart and enveloping, treating hernia pain. In Rihuazi Bencao, it is mentioned that Danshen can "discharge pus, stop pain, promote tissue regeneration and grow flesh"; breaking old blood, and replenishing new blood; malignant sore, scabies, goiter, wart, erysipelas; headache, red eyes, warm, mania and stuffiness due to heat. For acute urticaria and scabies on skin, it is washed externally with Danshen decoction (four red sage roots and two red sage roots, four sophora roots and three cnidium fruit) from Shenghui Fang. Danshen root can cool blood and resolve carbuncle, activate blood and resolve stasis, and remove heat-toxin, stasis can be removed, internal and external pathogenic qi can be removed, so it is good in treating sores, carbuncles, swollen and toxic effects due to heat-toxin stasis, and it is often combined with heat-clearing herbs such as jin Yin Hua, yin Qiao, pu Gong Ying, xia Ku Cao, huang Qin and Ku Shen in clinical syndrome.

(7) Selfheal: it is pungent, bitter and cold in nature, enters liver and gallbladder meridians, and has the effects of relieving swelling, dispersing pathogen accumulation, purging pathogenic fire, clearing away heat, and improving eyesight. The traditional Chinese medicine composition is clinically used for treating diseases such as conjunctival congestion, swelling and pain, bulbar nociception, headache, dizziness, scrofula, goiter, mammary abscess, mammary gland hyperplasia, breast cancer, tuberculous lymphadenitis, hypertension and the like. Recorded in the de-mix herbal medicine, "Xia Ku Cao is slightly pungent and bitter and has cold qi. Enters the qi system of foot jueyin meridian. Relieve the heat accumulated in yin and promote blood circulation. In this Jing, it is said that "cold and heat, scrofula, fistula, head sore, broken symptoms, goiter and qi stagnation, and foot swelling and damp arthralgia" are mainly observed. It is said that it can remove phlegm and eliminate pus, treat scrofula, clear the upper and nourish the lower, remove eye membrane and alleviate pain in Sheng Cao medical Property Bian (raw herb medicinal Property treatise).

(8) Flavescent sophora root: the medicine has bitter and cold property, enters liver, heart, large intestine, stomach and bladder channels, can eliminate dampness and heat, kill parasites, relieve itching and induce diuresis. The traditional Chinese medicine composition is clinically used for treating skin itch, damp-heat diarrhea, hemafecia, dysuresia, eczema, jaundice, leucorrhea with reddish discharge, vulva swelling and pruritus vulvae, mange tinea and eczema, trichomonas vaginitis and other diseases. The book Ben Cao Zheng Yi (materia Medica) carries that the actions of Ku Shen, which is bitter and cold, bringing down the fever and purging the descending, and washing out damp-fire are similar to those of Qin, lian and Dan Geng, but Ku Shen, which is bitter and even bitter, can kill the insects caused by damp-heat. The treatise on the treatise of the drug property is that the medicament can treat heat-toxin wind, skin and muscle fantod and sore, scabby eyebrow and alopecia, mainly remove the hot and somnolence, cold and pain in the abdomen and middle nausea, and remove body distress and accumulation of heart and abdomen.

(9) Raw licorice root: has sweet and mild property, enters spleen, lung, heart and stomach meridians, can eliminate phlegm and relieve cough, tonify spleen and qi, detoxify and clear heat, relieve spasm and pain and harmonize the medicaments. Can be used for treating spleen deficiency, listlessness, limb spasm, pain, excessive phlegm, cough, palpitation, short breath, abdominal pain, skin ulcer, carbuncle, and swelling, and relieving drug toxicity. Raw gan Cao is sweet in flavor and slightly cold in nature, good at clearing heat and removing toxicity, and can be used for treating heat-toxicity sores and ulcers, drug poisoning, food poisoning, sore throat and peptic ulcer. The book of Lai (the book of Lai) carries Licorice root, radix Glycyrrhizae Praeparata, which is effective in strengthening the muscles and bones, strengthening the five viscera and six house, strengthening the muscles and tendons, strengthening the body resistance, and relieving swelling and toxicity of incised wound. The theory of drug properties means that it can' give priority to cold pain in the abdomen, treat fright epilepsy, remove abdominal distension. It is used in addition. Recorded in Yao Huayi (materia medica records that liquorice, raw, cool and purging fire, mainly dispel exterior pathogen, eliminate carbuncle and swelling, relieve sore throat, relieve various drug toxicity, remove accumulated heat in stomach and remove pain in ureter, and also has sweet and cool effects of removing heat.

Has the beneficial effects that: the traditional Chinese medicine provided by the invention has the total effective rate of 91.67%, the cure rate of 80-95%, and the clinical effect of treating acne is definite, the effect is quick, the safety is high, the side effect is less, and the life quality of patients is improved.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are merely illustrative of the present invention and do not limit the scope of the present invention in any way.

Example 1

A traditional Chinese medicine composition for external use for treating acne comprises the following components in parts by weight: 15 parts of honeysuckle, 8 parts of scutellaria baicalensis, 8 parts of mung bean coat, 10 parts of semen cuscutae, 10 parts of rhizoma kaempferiae, 10 parts of salvia miltiorrhiza, 6 parts of selfheal, 10 parts of sophora flavescens and 5 parts of raw liquorice.

The preparation method of the external traditional Chinese medicine composition for treating acne comprises the following steps:

(1) Weighing the following components in proportion: honeysuckle, scutellaria baicalensis, mung bean coat, semen cuscutae, rhizoma kaempferiae, salvia miltiorrhiza, selfheal, sophora flavescens and raw liquorice; cleaning all Chinese medicinal materials, and removing impurities and non-medicinal parts;

(2) Adding 10 times of water into the above traditional Chinese medicines, decocting for 1 hr each time for 2 times, filtering, mixing decoctions, concentrating, centrifuging at 5000 rpm for 15 min, collecting the supernatant, adding into matrix, stirring at 275 rpm for 1h to obtain traditional Chinese medicine liquid, adding the traditional Chinese medicines into facial mask cloth, sealing, and sterilizing.

Clinical trials applying the present invention:

a random and control test method is adopted, 72 patients suffering from acne vulgaris damp toxin with blood stasis are included, and the patients are randomly divided into a test group and a control group, wherein the test group (48 patients) is provided with the external mask of the example 1, the control group (24 patients) is provided with the external placebo mask, and the treatment course is four weeks. The number of acne lesions before and after treatment, the severity of acne, the acne patient specific quality of life score and the changes in skin physiological indices (red zone, brown zone, porphyrin, pores, percutaneous water loss, pH, oil and hydration) were observed.

The final effective cases were 71 cases, 48 cases in the test group and 23 cases in the control group.

The treatment method comprises the following steps: the cleaning facial cleanser can thoroughly clean skin, and can be applied to affected part by wetting for 20 min every day for one week, 2-3 times for the second week, and a treatment course is two weeks.

Criteria for judgment

The nimodipine method has the following calculation formula: therapeutic index = [ (. Total number of skin lesions before treatment-total number of skin lesions after treatment)/total number of skin lesions before treatment ] X100%

And (3) healing: the therapeutic index is more than or equal to 95 percent, or the symptoms disappear, and only a little pigmentation is left;

the effect is shown: 95 percent, the therapeutic index is more than or equal to 70 percent, and the symptoms are obviously relieved;

the method has the following advantages: the treatment index is more than or equal to 50 percent at 70 percent, and the symptoms are improved;

and (4) invalidation: therapeutic index < 50%, or clinical symptom exacerbation.

Total effective rate = (number of cure cases + number of significant cases + number of effective cases)/total number of cases x 100%.

As a result:

1. after one week of treatment, the total effective rate of the test group is 75.00% (36 cases), which is higher than that of the control group by 21.73% (5 cases), and the difference has statistical significance (P < 0.05); after four weeks of treatment, the total effective rate of the test group was 91.67% (44 cases), which is higher than that of the control group by 30.43% (7 cases), and the difference was statistically significant (P < 0.05).

2. After four weeks of treatment, the difference between the acne grades in the test group and the control group is statistically significant (P < 0.05); after the treatment of the test group, the number of patients with acne of grade III and IV is obviously reduced, and the number of patients with acne of grade I and II is obviously increased.

3. After four weeks of treatment, the test group had lower red zone and transdermal water loss than the control group, and the differences were statistically significant (P < 0.05); the test group had a higher hydration and PH than the control group, and the difference was statistically significant (P < 0.05).

Claims (2)

1. The external traditional Chinese medicine composition for treating acne is characterized by comprising the following components in parts by weight: 10-20 parts of honeysuckle, 5-10 parts of scutellaria baicalensis, 5-10 parts of mung bean coat, 5-15 parts of semen cuscutae, 5-15 parts of rhizoma kaempferiae, 5-15 parts of salvia miltiorrhiza, 1-6 parts of selfheal, 5-10 parts of sophora flavescens and 1-5 parts of raw liquorice.

2. The method for preparing a topical Chinese medicinal composition for treating acne as claimed in claim 1, wherein the steps are as follows:

(1) Weighing the following components in proportion: flos Lonicerae, scutellariae radix, testa Phaseoli Radiati, semen Cuscutae, rhizoma Kaempferiae, saviae Miltiorrhizae radix, prunellae Spica, radix Sophorae Flavescentis, and Glycyrrhrizae radix; cleaning all the Chinese medicinal materials, and removing impurities and non-medicinal parts;

(2) Adding 10 times of water into the above traditional Chinese medicines, decocting for 1 hr for 2 times, filtering, mixing decoctions, concentrating, centrifuging at 5000 rpm/min for 15 min, collecting the supernatant, adding into matrix, stirring at 275 rpm/min for 1 hr to obtain traditional Chinese medicine liquid, adding the traditional Chinese medicines into facial mask cloth, sealing, and sterilizing.