CN102727791B - Medicine for treating AIDS and preparation method thereof - Google Patents
Medicine for treating AIDS and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicine for treating AIDS, comprising the following herbal raw material extracts: 4-18 weight parts of Smilax glabra extract, 2-10 weight parts of honeysuckle extract, 2-10 weight parts of radix trichosanthis extract, 3-13 weight parts of prunella vulgaris extract, 2-10 weight parts of sophora flavescens extract, 3-13 weight parts of Paris polyphylla extract, 3-13 weight parts of herba epimedii extract, 2-8 weight parts of lithospermum extract, 2-8 weight parts of rhizoma imperatae extract, 2-8 weight parts of cortex lycii radicis extract, 2-8 weight parts of polyporus umbellatus extract, 2-8 weight parts of coix seed extract, 2-8 weight parts of pawpaw extract, 2-10 weight parts of rhizoma alismatis extract, 2-8 weight parts of semen plantaginis extract, 2-10 weight parts of Cortex dictamni extract, 1-5 weight parts of raw licorice, and 2-8 weight parts of Liquidambar formosana Hance extract. The invention further provides a preparation method of the medicine for treating AIDS. The medicine for treating AIDS can effective remove toxic dampness and heat, stop HIV replication and transmission in vivo, promote diuresis and resolve dampness, promote normal functioning of spleen and stomach, and increase immune cell CD4 of human body.
Description
Technical field
The invention belongs to technical field of medicine, be specifically related to a kind of Chinese medicine composition for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof.
Background technology
AIDS is that a kind of propagation is rapid, and case fatality rate is high, the infectious disease that global human is constituted a serious threat.According to World Health Organization (WHO) (WHO) report, end nearly hundred million people in the whole world in 2009 and infected HIV (human immunodeficiency virus), existing approximately 6,900 ten thousand people die from AIDS.Wherein, the new aids patient that infects in 2009 is 2,600,000 people approximately, and the number of dying from acquired immune deficiency syndrome (AIDS) approximately 1,800,000, wherein about 260,000 people of child.The acquired immune deficiency syndrome (AIDS) annual rate of growth of China is about 30%.
Think at present: the people of infected by HIV is the unique source of infection of primary disease.From context of detection, HIV the infected's various body fluid all are infectious, and its blood, seminal fluid, saliva, cervical secretions, cerebrospinal fluid, tear, milk and urine are all separable goes out HIV virus.But from EPDML evidence, observing, is mainly seminal fluid, cervical secretions and blood.
Acquired immune deficiency syndrome (AIDS) has long incubation period.From infected by HIV to clinical condition of illness, average out to 8-10 occurring.HIV the infected can be asymptomatic, and the general status such as body surface outward appearance are normal, but very strong infectiousness is arranged.
Acquired immune deficiency syndrome (AIDS) is in the distribution situation in the whole world: Africa is the area that HIV (human immunodeficiency virus) infection is the most serious, accounts for 2/3 of global HIV number of the infected.Asia is acquired immune deficiency syndrome (AIDS) area with fastest developing speed, and India's HIV (human immunodeficiency virus) infection number surpasses 4,000,000.Eastern Europe, Muscovite development are also very fast, and the number of this regional HIV infection in 2002 is up to more than 1,000,000.China in 2005 HIV the infected reaches 650,000 people, wherein AIDS patient 7.5 ten thousand people, spreading through sex intercourse accounts for 49.8%, shoot up propagates 48.6%, and mother-to-baby transmission reaches 1.6%.
Any record to acquired immune deficiency syndrome (AIDS) is never arranged on the Chinese medicine history.During explored medical treatment acquired immune deficiency syndrome (AIDS), at first according to the characteristics of incidence of acquired immune deficiency syndrome (AIDS), and pathology, symptom etc. are determined the ownership scope of wherein curing the desease and levying.Someone thinks that acquired immune deficiency syndrome (AIDS) is similar to pestilence, but the former is larger to the destructive power of body, and non-other virus can be compared.Due to acquired immune deficiency syndrome (AIDS) have morbidity extensively, be in a bad way, infectiousness is extremely strong, be easy to the characteristics such as popular, it should belong to the category of the traditional Chinese medical science " epidemic disease "; As the symptom according to acquired immune deficiency syndrome (AIDS) and clinical manifestation, it can belong to the feature of Epidemic Febrile Disease again.
The compositions of existing Treating Acquired Immune Deficiency Syndrome with Chinese Medicine, be mostly from herbal nature and Traditional Chinese medical theory, by analysis, selects Chinese prescription, often lacks sufficient clinical efficacy and experimentation evidence.Even some prescription has some clinical effectiveness, be mainly the observed result to the symptom and sign aspect, do not set up clear and definite immunomodulating index, cause the objectivity of curative effect judgement not strong.In addition, preparation technology is also often loaded down with trivial details, causes the cost costliness.
Summary of the invention
Technical problem to be solved by this invention is to overcome the defect of prior art, and a kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS) and preparation method thereof is provided.
The present invention is achieved in that a kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS), and it comprises the raw material of Chinese medicine extract components of following weight portion:
Rhizoma Smilacis Glabrae extract 4～18; Flos Lonicerae extract 2～10;
Radix Trichosanthis extract 2～10; Spica Prunellae extract 3～13;
Radix Sophorae Flavescentis extract 2～10; Rhizoma Paridis extract 3～13;
Herba Epimedii extract 3～13; Radix Arnebiae extract 2～8;
Rhizoma Imperatae extract 2～8; Cortex Lycii extract 2～8;
Polyporus extract 2～8; Semen Coicis extract 2～8;
Fructus Chaenomelis extract 2～8; Rhizoma Alismatis extract 2～10;
Semen Plantaginis extract 2～8; Cortex Dictamni extract 2～10;
Radix Glycyrrhizae extract 1～5; Fructus Lipuidambaris extract 2～8.
And, a kind of preparation method for the treatment of the medicine of acquired immune deficiency syndrome (AIDS), it comprises the steps:
Formula according to the medicine of above-mentioned treatment acquired immune deficiency syndrome (AIDS) takes each raw material of Chinese medicine extract components;
The PROCESS FOR TREATMENT that can accept on the method and formulation that described raw material of Chinese medicine extract can be understood according to Pharmacists, make any oral formulations type medicine, obtains the medicine of described treatment acquired immune deficiency syndrome (AIDS).
The medicine for the treatment of acquired immune deficiency syndrome (AIDS) of the present invention, as the evil principal agent of the damp and hot poison for the treatment of, as monarch, get the economic benefits and social benefits that its specimen is held concurrently and made by Rhizoma Smilacis Glabrae in side; Flos Lonicerae, Spica Prunellae, Radix Sophorae Flavescentis heat-clearing and toxic substances removing, loose carbuncle detumescence; Radix Trichosanthis, heat clearing away is gone dry, removing toxicity for eliminating carbuncles, peaceful lung cough-relieving; But the copying and breeding in vivo of Herba Epimedii, Radix Trichosanthis inhibiting HIV (HIV), and can improve body immunity.But Rhizoma Paridis, Radix Arnebiae (Radix Lithospermi) heat-clearing and toxic substances removing; Rhizoma Imperatae, Cortex Lycii cooling blood for hemostasis, be the good merchantable brand of reducing the asthenic fever.Nine medicines mutually 5 help the clear away the dampness and heat power of evil poison of Rhizoma Smilacis Glabrae for minister altogether.Polyporus promoting diuresis to eliminate damp pathogen in side; The heart of a lotus seed is with core spleen invigorating eliminating dampness by diuresis; But Fructus Chaenomelis is invigorating the spleen for eliminating dampness also, relaxing muscles and tendons and activating QI and blood in the collateral; The Rhizoma Alismatis diuretic, eliminating dampness by diuresis, pathogenic fire purging; The Semen Plantaginis eliminating dampness by diuresis is treating stranguria; Cortex Dictamni can heat clearing and damp drying, can go again wind antipruritic, is treatment eczema, the key medicine of skin ulcer.Above Six-element medicine is the medicine of eliminating dampness by diuresis heat clearing away for assistant, by promoting diuresis to eliminate damp pathogen, reaches the spleen invigorating stomach strengthening, improves the purpose of autoimmune function.Radix Glycyrrhizae has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, the effect of buffering blood flow; Fructus Liquidambaris has promoting blood circulation and detumescence, granulation promoting pain relieving, external hemostasis, has the effect that dispelling, collateral-activating, diuretic stimulate the menstrual flow.This Chinese medicine composition, can remove the damp and hot evil poison in the HIV sufferers lungs, effectively stops HIV to copy in vivo and propagate, promoting diuresis to clear away damp pathogen, while invigorating the spleen and stomach, the clinical effectiveness of the immunocyte CD4 of increase human body.Further, the preparation method of the Chinese medicine composition for the treatment of acquired immune deficiency syndrome (AIDS) is simple, and technological process is short, is easy to produce, and cost is low.
The accompanying drawing explanation
Fig. 1 is the flow chart of process for preparing medicine of the treatment acquired immune deficiency syndrome (AIDS) of the embodiment of the present invention.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
The embodiment of the present invention provides a kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS), and the medicine of this treatment acquired immune deficiency syndrome (AIDS) comprises the raw material of Chinese medicine extract components of following weight portion:
Rhizoma Smilacis Glabrae extract 4～18; Flos Lonicerae extract 2～10;
Radix Trichosanthis extract 2～10; Spica Prunellae extract 3～13;
Radix Sophorae Flavescentis extract 2～10; Rhizoma Paridis extract 3～13;
Herba Epimedii extract 3～13; Radix Arnebiae extract 2～8;
Rhizoma Imperatae extract 2～8; Cortex Lycii extract 2～8;
Polyporus extract 2～8; Semen Coicis extract 2～8;
Fructus Chaenomelis extract 2～8; Rhizoma Alismatis extract 2～10;
Semen Plantaginis extract 2～8; Cortex Dictamni extract 2～10;
Radix Glycyrrhizae extract 1～5; Fructus Lipuidambaris extract 2～8.
Wherein, the present invention treats the raw material of Chinese medicine extract of AIDS-treating medicine and can buy by commercially available, also can obtain by existing each raw material of Chinese medicine extracting method.
Preferably, the medicine of this treatment acquired immune deficiency syndrome (AIDS) comprises the raw material of Chinese medicine extract components of following weight portion:
Rhizoma Smilacis Glabrae extract 10～12; Flos Lonicerae extract 5～7;
Radix Trichosanthis extract 5～7; Spica Prunellae extract 6～8;
Radix Sophorae Flavescentis extract 5～7; Rhizoma Paridis extract 6～8;
Herba Epimedii extract 6～8; Radix Arnebiae extract 3～5;
Rhizoma Imperatae extract 3～5; Cortex Lycii extract 3～5;
Polyporus extract 3～5; Semen Coicis extract 3～5;
Fructus Chaenomelis extract 3～5; Rhizoma Alismatis extract 5～7;
Semen Plantaginis extract 3～5; Cortex Dictamni extract 5～7;
Radix Glycyrrhizae extract 2～4; Fructus Lipuidambaris extract 3～5.
More preferably, the medicine of this treatment acquired immune deficiency syndrome (AIDS) comprises the raw material of Chinese medicine extract components of following weight portion:
Rhizoma Smilacis Glabrae extract 11.2; Flos Lonicerae extract 5.6;
Radix Trichosanthis extract 5.6; Spica Prunellae extract 7.5;
Radix Sophorae Flavescentis extract 5.6; Rhizoma Paridis extract 7.5;
Herba Epimedii extract 7.5; Radix Arnebiae extract 4.5;
Rhizoma Imperatae extract 4.5; Cortex Lycii extract 4.5;
Polyporus extract 4.5; Semen Coicis extract 4.5;
Fructus Chaenomelis extract 4.5; Rhizoma Alismatis extract 5.6;
Semen Plantaginis extract 4.5; Cortex Dictamni extract 5.6;
Radix Glycyrrhizae extract 2.5; Fructus Lipuidambaris extract 4.5.
the mankind are after aids infection poison (HIV), the symptom that exactly likes " upper sense " is often arranged, i.e. headache, heating, cough, nasal obstruction, laryngopharynx swelling and pain, whole-body muscle, arthralgia etc., through one section, infect period of expansion, enter the acquired immune deficiency syndrome (AIDS) period of disease, the symptom of organic opportunistic infections and sign occur, as long-term fever, do not move back, stomatitis appears, tonsillitis, thrush, inappetence, dysphagia, anorexia, progressive emaciation, lose weight, and the clinical manifestations such as multiple cutaneous inflammation are arranged, according to these Clinical symptoms, differential diagnosis in tcm should be controlled with " lung " and " spleen " the two dirty analytics of carrying out.Lung governing qi, department breathes; Lung controlling dispersing outward and inwards, regulating fluid apssage; The convergence of vessels in the lung (pulmonary circulation), close fur outward, and with large intestine phase the exterior and the interior.After the damp and hot evil poison of pulmonary infection (HIV), heating, headache, cough symptom, at first appear in impaired lung function, also occurs the diseases such as rhinocleisis, swelling and sore throat, whole body joint, myalgia simultaneously.Lung controlling dispersing outward and inwards, reach in fur outward, if lung endogenous dampness pathogenic heat poison is detained and does not go, scytitis mostly occurs.The lung and the large intestine being interior-exteriorly related, evil drug-pedlar's lung, impairment of purifying and descending function of the lung, can not normally input each internal organs of human body by materials such as water liquid, nutrition, can not effectively the refuse after body metabolism, body fluid etc. be turned to perspiration and urine excretes, cause Large intestine function disorder and chronic diarrhea occurs.
The spleen being the foundation of acquired constitution.Its effect: 1, main transporting.Spleen is source of generating QI and blood.Namely institute's ingesta is digested, absorb precise and tiny and water liquid wherein, then be transported to other important internal organs, tissue, after one's own heart, lung etc.2, blood under the overall leadership.Spleen can be controlled at blood in vascular and circulate.Spleen preferring dryness to dampness, have one's ideas straightened out in mouth, fills its flesh, and China is at lip.In case damp and hot evil poison (HIV) enters blood (vascular) afterwards, the imbalance of the transportation capabilities of spleen, conduct unable, function mistake department, precise and tinyization source can not absorb.The appearance human body is become thin and is carried out gonosome and heavily alleviates.Spleen preferring dryness to dampness, in case retention of water-damp within middle-JIAO, the body fluid metabolism just there will be obstacle, the symptom such as stomatitis, thrush, oral mucosa erosion as seen, or chronic diarrhea occur.In addition, spleen and stomach phase the exterior and the interior, splenic function mistake department, gastric qi is also deficient, and resistance has been received at the stomach mansion, causes dyspepsia, inappetence, dysphagia, or the symptom such as anorexia occurs, is inevitable outcome.
In view of above-mentioned analysis, " marking real deficiency in origin " is the basic place of this disease." mark is real " is attributed to lung, and " deficiency in origin " root is in spleen.On tcm clinical practice, " mark is real " shows as the clinical symptoms of various opportunistic infection; " deficiency in origin " shows as the human body immunodeficiency that the minimizing because of cd4 cell causes.
Therefore, select above-mentioned each raw material of Chinese medicine extract to remove the damp and hot evil poison in lungs, effectively to stop HIV to copy in vivo and to propagate; Promoting diuresis to clear away damp pathogen, invigorating the spleen and stomach, the immunocyte CD4 of increase human body.The meridian distribution of property and flavor of each raw material of Chinese medicine extract, composition pharmacology and effect application are as follows.
Rhizoma Smilacis Glabrae extract: meridian distribution of property and flavor: sweet, light, flat; Return liver, stomach, spleen channel.Composition pharmacology: contain alkaloid, volatile oil, hexose, tannin, plant sterol and linoleic acid, oleic acid etc.The effect application: the strong muscle of bone strengthening, stopping leak are held back intestinal, easing joint movement, have the evil effect of the pyretic toxicity of drying.
Flos Lonicerae extract: meridian distribution of property and flavor: sweet, cold; Return lung, the heart, stomach warp.Composition pharmacology: contain chlorogenic acid, inositol, Saponin and pure cellulose.Effect application: for various febrile diseases, dispelling wind-heat, kind removing summer-heat blood poison also, have antibacterial, antiviral, antiinflammatory, analgesic, regulate immunization.
Radix Trichosanthis extract: meridian distribution of property and flavor: sweet, micro-hardship, be slightly cold; Attach to the lung and stomach meridians.Composition pharmacology: contain the compositions such as trichosanthin and enzyme inhibitor class.Effect application: for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, and sore swollen toxin has promoting the production of body fluid to quench thirst, clearing away heat-fire, evacuation of pus detumescence, suppresses virus copying and breeding in vivo, improves the body immunity effect.
Spica Prunellae extract: meridian distribution of property and flavor: bitter, acrid, cold; Return Liver Channel.Composition pharmacology: contain triterpene and glycoside thereof, sterol and glycoside thereof, flavonoid, coumarin, organic acid, volatile oil and saccharide etc.Effect application: the improving eyesight of relieving inflammation or internal heat, mass dissipating and swelling eliminating have liver heat removing, blood pressure lowering, blood sugar lowering, antibiotic, antiinflammatory, antiallergic and antivirus action.
Radix Sophorae Flavescentis extract: meridian distribution of property and flavor: bitter, cold; GUIXIN, liver, stomach, large intestine, urinary bladder channel.Composition pharmacology: contain multiple alkaloid and multiple flavone compound.The effect application: heat clearing and damp drying, parasite killing, diuresis have heat-clearing and toxic substances removing, loose carbuncle detumescence effect.
Rhizoma Paridis extract: meridian distribution of property and flavor: bitter, cool, mild toxicity; GUIXIN warp, Liver Channel, lung meridian, stomach warp, large intestine channel.Composition pharmacology: contain diosgenin-3-O-α-D-pyranglucoside etc. and alanine, the several amino acids such as agedoite.Effect application: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver have anticancer, the reducing swelling and alleviating pain of relieving internal heat, heat clearing away arresting convulsion, antitussive and antiasthmatic effect.
Herba Epimedii extract: meridian distribution of property and flavor: acrid, sweet, warm; Return liver, kidney channel.Composition pharmacology: contain flavone compound, lignanoid, alkaloid, volatilization wet goods.Effect application: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling have raising hypophysis---the effect of interrenal system function, and can enhancing antibody formation effect, suppress virus copying and breeding in vivo, and improve the body immunity effect.
Radix Arnebiae extract: meridian distribution of property and flavor: cold, sweet, salty; GUIXIN, Liver Channel.Composition pharmacology: contain pigment composition, fatty acid.The effect application: removing heat from blood, blood circulation promoting and blood stasis dispelling, detoxifcation rash have antipyretic and antidote functions.
Rhizoma Imperatae extract: meridian distribution of property and flavor: sweet, cold; Return lung, stomach, small intestine meridian.Composition pharmacology: contain volume sucrose, glucose, a small amount of fructose, xylose and citric acid, oxalic acid, malic acid etc.The effect application: moistening and cleaning throat profit lung, antipyretic-antalgic, removing pathogenic heat from blood and toxic substance from the body have cooling blood for hemostasis, antipyretic and antidote functions.
Cortex Lycii extract: meridian distribution of property and flavor: sweet, cold; Return lung, liver, kidney channel.Composition pharmacology: contain cinnamic acid and volume aldehydes matter, betanin.The effect application: blood-activating and qi-promoting, cooling blood for hemostasis have removing heat from blood except steaming, the effect of lung heat clearing pathogenic fire reducing.
Polyporus extract: meridian distribution of property and flavor: sweet, light, flat; Return kidney, urinary bladder channel.Composition pharmacology: contain Polyporus polysaccharide 1, ergosterol, Alpha-hydroxy 24 carbonic acid, saccharide, crude protein etc.The effect application: promoting diuresis to eliminate damp pathogen has the diuresis damp eliminating, strengthens immunization.
Semen Coicis extract: meridian distribution of property and flavor: sweet, light, cool; Return spleen, stomach, lung meridian.Composition pharmacology: contain aminoacid, Coixol, Coixenolide, triterpenoid, protein, fat, carbohydrate, vitamin B1.The effect application: inducing diuresis to remove edema, arthralgia relieving by relaxing muscles and tendons, eliminating impediment pain relieving have spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus effect.
Fructus Chaenomelis extract: meridian distribution of property and flavor: sweet, put down, be slightly cold; Return liver, spleen channel.Composition pharmacology: contain oleanolic acid, Fructus Chaenomelis phenol, Saponin, malic acid, tartaric acid, citric acid, vitamin C, flavonoid etc.Effect application: relieve summer heat quench one's thirst, nourishing the lung to arrest cough, have invigorating the spleen for eliminating dampness, relaxing muscles and tendons and activating QI and blood in the collateral effect.
Rhizoma Alismatis extract: meridian distribution of property and flavor: sweet, light, cold; Return kidney, urinary bladder channel.Composition pharmacology: contain volatile oil, alkaloid, asparagine, plant sterol, phytosterolin, multiple fatty acid (Palmic acid, stearic acid, oleic acid, linoleic acid), Alisol A, alisol B etc.The effect application: eliminating fire and detoxication, removing damp-heat have diuretic, eliminating dampness by diuresis, pathogenic fire purging heat clearing away effect.
Semen Plantaginis extract: meridian distribution of property and flavor: sweet, cold; Return kidney, bladder, liver, lung meridian.Composition pharmacology: contain volume mucus, plantenolic acid, plantagoside, plantenolic acid, succinic acid, adenine, choline, catalpol, protein and various fatty acids etc.The effect application: eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat-phlegm have clearing away heat and promoting diuresis, relieving stranguria by diuresis effect.
Cortex Dictamni extract: meridian distribution of property and flavor: bitter, salty, cold; Return spleen, stomach warp.Composition pharmacology: contain dictamine, dictamnolactone, sitosterol, obacunonic acid, trigonelline, choline, Ash skin ketone etc.The effect application: heat clearing and damp drying, detoxifcation have heat-clearing and toxic substances removing, dispelling wind for relieving itching effect.
Radix Glycyrrhizae extract: meridian distribution of property and flavor: sweet, flat; Return lung, spleen, stomach warp.Composition pharmacology: contain Radix Glycyrrhizae and lick element, liquiritin, hormonelike composition.The effect application: invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription have the effect of buffering blood flow.
Fructus Lipuidambaris extract: meridian distribution of property and flavor: hardship, flat; Return liver, kidney channel.Composition pharmacology: contain the nor-oleanonic acid of 28-, styracin, left-handed cinnamic acid borneol acetate, epoxy styracin, different epoxy styracin, trans-Caryophyllene oxide, Betulonic acid, 24-ethyl gallbladder steroid-5-enol.The effect application: promoting blood circulation and detumescence, granulation promoting pain relieving, external hemostasis have dispelling, collateral-activating, the diuretic effect of stimulating the menstrual flow.
Above-mentioned all medicines coordinate, and remove the damp and hot evil poison of lungs---cut its mark, Gu promoting diuresis to clear away damp pathogen causes the strong fortune of taste---its.In side, Rhizoma Smilacis Glabrae, as the evil principal agent of the damp and hot poison for the treatment of, as monarch, is got the economic benefits and social benefits that its specimen is held concurrently and made.Flos Lonicerae, Spica Prunellae, Radix Sophorae Flavescentis, Radix Trichosanthis, Herba Epimedii, Radix Trichosanthis, Rhizoma Paridis, Radix Arnebiae (Radix Lithospermi), Rhizoma Imperatae, Cortex Lycii 5 be minister mutually, help altogether the clear away the dampness and heat power of heresy poison of Rhizoma Smilacis Glabrae.Polyporus, the heart of a lotus seed are the medicine of eliminating dampness by diuresis heat clearing away with core, Fructus Chaenomelis, Rhizoma Alismatis, Semen Plantaginis, Cortex Dictamni, by promoting diuresis to eliminate damp pathogen, reach the spleen invigorating stomach strengthening, improve the purpose of autoimmune function.It can make hard capsule, to facilitate the patient, takes.
Refer to Fig. 1, show a kind of preparation method for the treatment of the medicine of acquired immune deficiency syndrome (AIDS) of the embodiment of the present invention, it comprises the steps:
S01: the formula according to the medicine of above-mentioned treatment acquired immune deficiency syndrome (AIDS) takes each raw material of Chinese medicine extract components;
S02: the PROCESS FOR TREATMENT that can accept on the method and formulation that described raw material of Chinese medicine extract can be understood according to Pharmacists, make any oral formulations type medicine, obtain the medicine of described treatment acquired immune deficiency syndrome (AIDS).
Particularly, above-mentioned steps S01, in the medicine for the treatment of acquired immune deficiency syndrome (AIDS), the preferred content of each raw material of Chinese medicine extract components as described above, in order to save length, does not repeat them here.
In above-mentioned steps S02, preferably, be hard capsule preparation.The said preparation process is simply effective.The technique of described hard capsule preparation is: described raw material of Chinese medicine extract components mixed, and radiation sterilizing, drying, obtain the Chinese medicine composition composition granule; Described Chinese medicine composition composition granule is incapsulated, obtain the medicine of described treatment acquired immune deficiency syndrome (AIDS).Described raw material of Chinese medicine extract components needs pulverizing, sieve powder before mixing, with the uniformity of eliminating the caking material and guaranteeing following process.The environment of radiation sterilizing is: 60Co radiation sterilization, irradiation dose≤6KGY.The concentration that adds its weight 5% after radiation sterilizing is 70% ethanol; with the trough-type mixture machine mix homogeneously, make soft material; use granulation machine that soft material is crossed to 10～16 mesh sieves and must make granule; the described soft material made from the trough-type mixture machine mix homogeneously can the group of holding with hands and is not sticky, with the light finger pressure energy, splits for suitable.And to select oven drying, baking temperature be 50～60 ℃, and be 2～3h drying time.Granulate after dry, obtain the Chinese medicine composition composition granule; Under aseptic condition, described Chinese medicine composition composition granule is incapsulated, obtain the medicine of described treatment acquired immune deficiency syndrome (AIDS).In above-mentioned capsule, can also add pharmaceutically acceptable adjuvant, as starch etc.
The medicine for the treatment of acquired immune deficiency syndrome (AIDS) of the present invention is through routine clinical trials up to a hundred, and main aids patient take states such as China, African South Africa, Britain, Zimbabwe is as object.Most patient is the symptoms such as heating, headache, pharyngalgia, cough, nasal obstruction, laryngopharynx swelling and pain, whole-body muscle arthralgia, weak, general malaise when medical, and the symptom lasting for years, and what have even reaches more than ten years.Most of clients have pulmonary infection, symptoms of pneumonia occurs, and tired, unable, weight loss, many HIV sufferers be concurrent tumor, tuberculosis and dementia simultaneously.During test, to HIV (human immunodeficiency virus) HIV positive patient, by every day, take for three times, three months is a course for the treatment of, and medication one, to after two months, has the chemical examination of half patient blood to turn negative.To HIV sufferers, every day three times, three months is a course for the treatment of, and depending on conditions of patients, each patient at least two is to four courses for the treatment of, to frank aids patient, and after one week of medication, 70% patient, its heating can be eliminated, and oral ulcer is clearly better.After two weeks of medication, 80% patient's appetite improves, its pulmonary infection, headache, cough, and laryngopharynx swelling and pain, oral cavity are smelly, esophagitis, chronic diarrhea, scytitis etc., all take a favorable turn.After taking medicine one month, symptom is obviously improved.Patient's appetite is improved, tired alleviating, and muscle power is obviously recovered, and body weight also increases to some extent.Street virus is infected or the infection by Treponema pallidum person, and one month is a course for the treatment of, generally takes medicine one to two months, and the state of an illness can be controlled.After taking medicine three to six months, the cd4 cell in the patient body more than 85% has increase, and every milliliter of blood cd4 cell on average increases by 50 to 250, and immunity of organisms also improves thereupon, and patient's muscle power strengthens, and body weight increases, and overall health of patients is obviously improved.Test shows, the Drug therapy acquired immune deficiency syndrome (AIDS) effect for the treatment of acquired immune deficiency syndrome (AIDS) of the present invention is remarkable.
The medicine for the treatment of acquired immune deficiency syndrome (AIDS) provided by the invention, the damp and hot evil poison in lungs, loose carbuncle detumescence, heat clearing away be can effectively remove and dry, removing toxicity for eliminating carbuncles, peaceful lung cough-relieving gone, effectively stop HIV to copy in vivo and propagate, promoting diuresis to clear away damp pathogen, invigorating the spleen and stomach, relaxing muscles and tendons and activating QI and blood in the collateral, eliminating dampness by diuresis is treating stranguria, heat clearing and damp drying, can go again wind antipruritic, increase the immunocyte CD4 of human body.Further, the medicine for the treatment of acquired immune deficiency syndrome (AIDS) of the present invention is pure natural medical herbs, has no side effect, and without hepatic and renal function injure, without any untoward reaction, has significant antiviral effect.
Below embodiment by concrete formula and preparation method medicine of above-mentioned treatment acquired immune deficiency syndrome (AIDS) and preparation method thereof is described.
Embodiment 1:
By Rhizoma Smilacis Glabrae, Flos Lonicerae, Radix Trichosanthis, Spica Prunellae, Radix Sophorae Flavescentis, Rhizoma Paridis, Herba Epimedii, Radix Arnebiae (Radix Lithospermi), Rhizoma Imperatae, Cortex Lycii, Polyporus, Semen Coicis, Fructus Chaenomelis, Rhizoma Alismatis, Semen Plantaginis, Cortex Dictamni, Radix Glycyrrhizae, Fructus Liquidambaris raw material of Chinese medicine according to traditional extraction process respectively through pulverizing, extract, filter, concentrated, spray drying, sieving obtains the extract of raw material of Chinese medicine;
take Rhizoma Smilacis Glabrae extract 11.2 grams, Flos Lonicerae extract 5.6 grams, Radix Trichosanthis extract 5.6 grams, Spica Prunellae extract 7.5 grams, Radix Sophorae Flavescentis extract 5.6 grams, Rhizoma Paridis extract 7.5 grams, Herba Epimedii extract 7.5 grams, Radix Arnebiae extract 4.5 grams, Rhizoma Imperatae extract 4.5 grams, Cortex Lycii extract 4.5 grams, polyporus extract 4.5 grams, Semen Coicis extract 4.5 grams, Fructus Chaenomelis extract 4.5 grams, Rhizoma Alismatis extract 5.6 grams, Semen Plantaginis extract 4.5 grams, Cortex Dictamni extract 5.6 grams, Radix Glycyrrhizae extract 2.5 grams, and Fructus Lipuidambaris extract 4.5 grams, after it is mixed according to traditional preparation technology through radiation sterilizing, dry and make the Chinese medicine composition composition granule, and this Chinese medicine composition composition granule is incapsulated, make 250, every approximately 400 milligrams, obtain the medicine of this treatment acquired immune deficiency syndrome (AIDS).
Embodiment 2:
take commercially available Rhizoma Smilacis Glabrae extract 16 grams, Flos Lonicerae extract 10 grams, Radix Trichosanthis extract 10 grams, Spica Prunellae extract 12 grams, Radix Sophorae Flavescentis extract 10 grams, Rhizoma Paridis extract 12 grams, Herba Epimedii extract 12 grams, Radix Arnebiae extract 8 grams, Rhizoma Imperatae extract 8 grams, Cortex Lycii extract 8 grams, polyporus extract 8 grams, Semen Coicis extract 8 grams, Fructus Chaenomelis extract 8 grams, Rhizoma Alismatis extract 8 grams, Semen Plantaginis extract 8 grams, Cortex Dictamni extract 8 grams, Radix Glycyrrhizae extract 4 grams, and Fructus Lipuidambaris extract 8 grams, after it is mixed according to traditional preparation technology through radiation sterilizing, dry and make the Chinese medicine composition composition granule, and this Chinese medicine composition composition granule is incapsulated, obtain the medicine of this treatment acquired immune deficiency syndrome (AIDS).
Embodiment 3:
take commercially available Rhizoma Smilacis Glabrae extract 4 grams, Flos Lonicerae extract 2 grams, Radix Trichosanthis extract 2 grams, Spica Prunellae extract 3 grams, Radix Sophorae Flavescentis extract 2 grams, Rhizoma Paridis extract 3 grams, Herba Epimedii extract 3 grams, Radix Arnebiae extract 2 grams, Rhizoma Imperatae extract 8 grams, Cortex Lycii extract 2 grams, polyporus extract 2 grams, Semen Coicis extract 8 grams, Fructus Chaenomelis extract 2 grams, Rhizoma Alismatis extract 10 grams, Semen Plantaginis extract 8 grams, Cortex Dictamni extract 8 grams, Radix Glycyrrhizae extract 1 gram, and Fructus Lipuidambaris extract 2 grams, after it is mixed according to traditional preparation technology through radiation sterilizing, dry and make the Chinese medicine composition composition granule, and this Chinese medicine composition composition granule is incapsulated, obtain the medicine of this treatment acquired immune deficiency syndrome (AIDS).
Embodiment 4:
take commercially available Rhizoma Smilacis Glabrae extract 10 grams, Flos Lonicerae extract 7 grams, Radix Trichosanthis extract 7 grams, Spica Prunellae extract 8 grams, Radix Sophorae Flavescentis extract 7 grams, Rhizoma Paridis extract 8 grams, Herba Epimedii extract 8 grams, Radix Arnebiae extract 5 grams, Rhizoma Imperatae extract 3 grams, Cortex Lycii extract 5 grams, polyporus extract 5 grams, Semen Coicis extract 3 grams, Fructus Chaenomelis extract 5 grams, Rhizoma Alismatis extract 7 grams, Semen Plantaginis extract 3 grams, Cortex Dictamni extract 7 grams, Radix Glycyrrhizae extract 4 grams, and Fructus Lipuidambaris extract 5 grams, after it is mixed according to traditional preparation technology through radiation sterilizing, dry and make the Chinese medicine composition composition granule, and this Chinese medicine composition composition granule is incapsulated, obtain the medicine of this treatment acquired immune deficiency syndrome (AIDS).
The medicine of the treatment acquired immune deficiency syndrome (AIDS) that above-described embodiment 1 is made carries out clinical practice.
Case 1:
Certain man, 37 years old, Chinese people from Anhui.The patient is symptom at that time: long-term fever, headache, pharyngalgia, weak, whole body are obviously become thin.Oral cavity has ulcer, skin many places that infection, agnogenio is arranged.Conditions of patients continues 3 years, and appetite is very poor, long-term diarrhea.Conventional anti-infective therapy is invalid, and heating is not moved back.The CD4 that has a blood test is 280.
Clinical diagnosis is: the acquired immune deficiency syndrome (AIDS) stage of attack
Differential diagnosis in tcm: at first the patient has heating, headache, cough symptom, also occurs the diseases such as swelling and sore throat, oral cavity, skin ulcer simultaneously.Lung controlling dispersing outward and inwards, reach in fur outward, if in lung, there is damp and hot evil poison to invade, is detained and do not go, and skin easily is inflamed and damages.The lung and the large intestine being interior-exteriorly related, evil drug-pedlar's lung, impairment of purifying and descending function of the lung, large intestine can not normally be inputted each internal organs of human body by materials such as water liquid, nutrition, can not effectively the refuse after body metabolism, body fluid etc. be turned to perspiration and urine excretes, cause Large intestine function disorder and chronic diarrhea occurs.
The scheme for the treatment of is: the patient takes 1 Chinese medicine every day of embodiment three times, and each four, three months is a course for the treatment of, takes two courses for the treatment of.
Therapeutic effect: take above-mentioned medicament after one week, patient's heating, headache, pharyngalgia are eliminated, and after one month, oral ulcer is clearly better, and after three months, patient's muscle power is clearly better, and body weight increases by two kilograms, and appetite also increases.Cd4 cell in body obviously increases, and every milliliter of blood cd4 cell is increased to 450.Immunity of organisms also improves thereupon, and patient's muscle power strengthens, and overall health of patients is obviously improved.
Case 2:
Certain man, 45 years old, African South African.
The patient is symptom at that time: 37.5～38.8 ℃ of prolonged low grade fevers, cough, uncomfortable in chest, abundant expectoration, have serious oral ulcer, companion's whole skin many places erosion, swelling and sore throat, invalid to antibiotic commonly used.The whole body pain of joint muscle, appetite is poor, obviously becomes thin, only 35 kilograms.Patients serum's HIV (human immunodeficiency virus) is strong positive.Several 170/milliliter of cd4 cell.
Clinical diagnosis: acquired immune deficiency syndrome (AIDS) clinical onset late period
The scheme for the treatment of is: the patient takes above-mentioned medicament every day three times, and each four, three months is a course for the treatment of, takes two courses for the treatment of.
Therapeutic effect: take embodiment 1 Chinese medicine after fortnight body temperature normal, the cough stop.Patient's appetite also starts to increase, and mental status takes a turn for the better; After three months, patient's oral ulcer is clearly better, and the infringement of skin many places recovers normal.Cd4 cell in body has increase, and every milliliter of blood cd4 cell increases to 450/milliliter, after six months, check CD4 is increased to 560/milliliter, and immunity of organisms also improves thereupon, and patient's muscle power strengthens, face also starts ruddy, and body weight increases by five kilograms, and overall health of patients is obviously improved.
Case 3:
Certain female, 51 years old, Chinese people from Fuyang.The patient is symptom at that time: low grade fever, becomes thin, and weak 1 year.Have a medical check-up: the blood chemical examination HIV positive, once was diagnosed as the acquired immune deficiency syndrome (AIDS) clinical onset phase by CD4280/milliliter in locality.The patient accepted two weeks of HAART chemotherapy, and because gastrointestinal reaction is violent, vomiting is frequent, the premature termination chemotherapy of having to.
The scheme for the treatment of is: the patient takes 1 Chinese medicine every day of embodiment three times, and each four, three months is a course for the treatment of, takes two courses for the treatment of.
Therapeutic effect: take above-mentioned medicament after two courses for the treatment of, patient's heating, weak elimination, appetite increases, and spirit is got better.Body weight increases by three kilograms.Blood chemical examination CD4 increases to 365/milliliter.At whole period in a medicine, have no adverse reaction.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. a medicine for the treatment of acquired immune deficiency syndrome (AIDS), is characterized in that, the raw material of Chinese medicine extract components of following weight portion, consists of:
Described raw material of Chinese medicine extract be by raw material of Chinese medicine according to traditional extraction process respectively through pulverizing, extract, filter, concentrated, spray drying, the acquisition of sieving.
2. the medicine for the treatment of acquired immune deficiency syndrome (AIDS) as claimed in claim 1, is characterized in that, the raw material of Chinese medicine extract components of following weight portion, consists of:
3. the medicine for the treatment of acquired immune deficiency syndrome (AIDS) as claimed in claim 1, is characterized in that, the raw material of Chinese medicine extract components of following weight portion, consists of:
4. the medicine of described treatment acquired immune deficiency syndrome (AIDS) as arbitrary as claim 1～3, is characterized in that, the medicine of described treatment acquired immune deficiency syndrome (AIDS) is hard capsule.
5. preparation method for the treatment of the medicine of acquired immune deficiency syndrome (AIDS), it comprises the steps:
Formula by the medicine of the arbitrary described treatment acquired immune deficiency syndrome (AIDS) of claim 1～3 takes each raw material of Chinese medicine extract components; The extracting method of described raw material of Chinese medicine extract be by raw material of Chinese medicine according to traditional extraction process respectively through pulverizing, extract, filter, concentrated, spray drying, sieve;
The PROCESS FOR TREATMENT that can accept on the method and formulation that described raw material of Chinese medicine extract can be understood according to Pharmacists, make any oral formulations type medicine, obtains the medicine of described treatment acquired immune deficiency syndrome (AIDS).
6. the preparation method of the medicine for the treatment of acquired immune deficiency syndrome (AIDS) as claimed in claim 5, is characterized in that, described oral formulations type medicine is hard capsule, and the preparation technology of described hard capsule is:
Will described raw material of Chinese medicine extract components pulverizing, mix after the sieve powder, and radiation sterilizing, granulation, drying, granulate, obtain the Chinese medicine composition composition granule;
Described Chinese medicine composition composition granule is incapsulated.
7. the preparation method of the medicine for the treatment of acquired immune deficiency syndrome (AIDS) as claimed in claim 6, is characterized in that, the environment of described radiation sterilizing is: the 60Co radiation sterilization, irradiation dose is less than or equal to 6KGY.
8. the preparation method of the medicine for the treatment of acquired immune deficiency syndrome (AIDS) as claimed in claim 6, is characterized in that, the temperature of described drying is 50～60 ℃, and the time is 2～3h.
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