CN103341078A - Chinese herba preparation for treating corticosteroid-dependent dermatitis and preparation method thereof - Google Patents
Chinese herba preparation for treating corticosteroid-dependent dermatitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an external Chinese medicine preparation for treating corticosteroid-dependent dermatitis and a preparation method thereof. The external Chinese medicine preparation for treating the corticosteroid-dependent dermatitis comprises a Chinese medicine composition and a pharmaceutically acceptable excipient, wherein the Chinese medicine composition comprises the following components in parts by weight: 15-25 parts of radix sophorae flavescentis, 15-20 parts of portulaca oleracea, 25-35 parts of raw coix seeds, 15-20 parts of belvedere fruits, 10-20 parts of golden cypress, 5-15 parts of Chinese violet, 10-20 parts of Chinese roses, 10-15 parts of ligusticum wallichii and 12-20 parts of ligusticum. The inventor wondrously finds that the medicine composition can be used for clearing away heat and toxic materials, promoting blood circulation, diminishing swelling, purging intense heat, detoxicating and promoting blood circulation to remove blood stasis, and can be effectively used for treating the corticosteroid-dependent dermatitis.
Description
Technical field
The present invention relates to the field of Chinese medicines, more specifically, the present invention relates to Chinese medicine for external application for the treatment of steroid-dependent dermatitis and preparation method thereof.
Background technology
Corticosteroid hormone such as prednisone, dexamethasone, Pevisone, fluocinonide etc. have tangible antiinflammatory, antiallergic and immunosuppressive action, thus be widely used in the treatment with immune diseases associated, and can bring about tangible results.But it has a lot of side effect again, and under the situation especially excessive at dosage, that service time is long, the people knows from experience the many bad reactions of appearance.Studies show that, the external of 17-hydroxy-11-dehydrocorticosterone preparation, to the infringement of skin more so.17-hydroxy-11-dehydrocorticosterone can Transdermal absorption, and at subcutaneous tissue, especially sebum film, horny layer and the skin appendages on the surface exists and store phenomenon.Hormone mainly is penetrating by hair follicle cortex gland, also can be penetrating by horny layer of epidermis.The glucocorticoid external can produce powerful, nonspecific antiinflammatory to local skin and do usefulness.To acute inflammation, collapsible blood vessel, alleviate hyperemia, reduce blood capillary permeability, reduce and ooze out, alleviate acutely inflamed red, swollen, hot, bitterly and function sexual disorders.To chronic inflammatory disease, can suppress granulation tissue hyperplasia, the adhesion and the spot that reduce inflammation and cause also have immunosuppressant and do usefulness, eliminate the inflammation due to the immunoreation.But long-term external hormone medicine and contain the cosmetics of hormone can cause symptom---" steroid-dependent dermatitis " such as atrophoderma, telangiectasis, pigmentation, dermatitis and infection, hirsutism, redness, desquamation, scratchy, dryings again.In recent years, steroid-dependent dermatitis is ascendant trend year by year because of morbidity, and obstinate refractory has become the focus that medical experts pay close attention to more again.At present the effective measures of the facial steroid-dependent dermatitis for the treatment of are to get rid of blood the inside hormone residues toxin, repair the damaged skin histiocyte at all.Tradition toxin expelling product is expelling intestinal toxin, and antihistaminic just plays temporary transient inhibitory action to allergy.Cause facial hormones dependence facial dermatitis patient to recur the painful situation that go fromes bad to worse repeatedly.
Yet, at present also there is not to be used for the treatment of the Chinese medicine preparation of steroid-dependent dermatitis, especially can be used for the treatment of the Traditional Chinese Medicine for external application preparation of steroid-dependent dermatitis.
Summary of the invention
The present invention one of is intended to solve the problems of the technologies described above at least to a certain extent or provides a kind of useful commerce to select at least.For this reason, one object of the present invention is to propose a kind of medicine that can effectively treat steroid-dependent dermatitis, and this medicine is mainly used in external application.
In one aspect of the invention, the present invention proposes a kind of Chinese medicine preparation for the treatment of steroid-dependent dermatitis.According to embodiments of the invention, this Chinese medicine for external application comprises: Chinese medicine composition and pharmaceutically acceptable excipient, and wherein said Chinese medicine composition comprises the Radix Sophorae Flavescentis of 15～25 weight portions; The Herba Portulacae of 15～20 weight portions; The Semen Coicis of 25～35 weight portions; The Fructus Kochiae of 15～20 weight portions; The Cortex Phellodendri of 10～20 weight portions; The Herba Violae of 5～15 weight portions; The Flos Rosae Chinensis of 10～20 weight portions; The Rhizoma Ligustici of the Rhizoma Chuanxiong of 10～15 weight portions and 12～20 weight portions.The inventor is surprised to find this Chinese medicine for external application can heat-clearing and toxic substances removing, promoting blood circulation and detumescence, eliminating fire and detoxication and the logical stasis of blood of invigorating blood circulation, and can be used for the treatment of steroid-dependent dermatitis effectively.According to embodiments of the invention, this Chinese medicine composition comprises the Radix Sophorae Flavescentis of 20 weight portions; The Herba Portulacae of 15 weight portions; The Semen Coicis of 30 weight portions; The Fructus Kochiae of 15 weight portions; The Cortex Phellodendri of 15 weight portions; The Herba Violae of 10 weight portions; The Flos Rosae Chinensis of 15 weight portions; The Rhizoma Chuanxiong of 10 weight portions; And the Rhizoma Ligustici of 15 weight portions.Thus, aforementioned pharmaceutical compositions can be with the drug effect between the optimal compatibility relationship coordinating the actions of various ingredients in a prescription, thereby improves the effect for the treatment of steroid-dependent dermatitis more significantly.
In a second aspect of the present invention, the present invention proposes a kind of method for preparing the Chinese medicine preparation of above-mentioned treatment steroid-dependent dermatitis.According to embodiments of the invention, this Chinese medicine for external application obtains through the following steps: supply raw materials according to following ratio: the Herba Violae of the Fructus Kochiae of the Herba Portulacae of the Radix Sophorae Flavescentis of 15～25 weight portions, 15～20 weight portions, the Semen Coicis of 25～35 weight portions, 15～20 weight portions, the Cortex Phellodendri of 10～20 weight portions, 5～15 weight portions, the Flos Rosae Chinensis of 10～20 weight portions, the Rhizoma Chuanxiong of 10～15 weight portions and the Rhizoma Ligustici of 12～20 weight portions, in order to obtain raw mix; Resulting raw mix is added to the water, decocted 30-50 minute, in order to obtain the decocting for Chinese herbal medicine medicinal liquid; Described decocting for Chinese herbal medicine medicinal liquid is filtered, concentrates, in order to obtain concentrated solution; Described concentrated solution is mixed with pharmaceutically acceptable excipient, in order to obtain described Chinese medicine preparation.The inventor find this Chinese medicine for external application can heat-clearing and toxic substances removing, promoting blood circulation and detumescence, eliminating fire and detoxication and promoting blood circulation to remove blood stasis, can be used for the treatment of steroid-dependent dermatitis effectively, and resulting medicine, can be used as application compress and be used for the treatment of the medicine of steroid-dependent dermatitis, use simply, directly the outer face that spreads on gets final product.
According to embodiments of the invention, can supply raw materials according to following ratio: the Herba Violae of the Fructus Kochiae of the Herba Portulacae of the Radix Sophorae Flavescentis of 20 weight portions, 15 weight portions, the Semen Coicis of 30 weight portions, 15 weight portions, the Cortex Phellodendri of 15 weight portions, 10 weight portions, the Flos Rosae Chinensis of 15 weight portions, the Rhizoma Chuanxiong of 10 weight portions and the Rhizoma Ligustici of 15 weight portions.Thus, aforementioned pharmaceutical compositions can be with the drug effect between the optimal compatibility relationship coordinating the actions of various ingredients in a prescription, thereby improves the effect for the treatment of steroid-dependent dermatitis more significantly.
According to embodiments of the invention, based on the weight of Radix Sophorae Flavescentis, the use amount of water and the weight ratio of Radix Sophorae Flavescentis are 500:15～25.Thus, can so that the effective ingredient in the Chinese medicine of respectively distinguishing the flavor of that contains in the medicine can be more fully go out dissolved come out at decoction process, thereby further improve the therapeutic effect of resultant medicine.
According to embodiments of the invention, resulting raw mix is added to the water, decocted 30～50 minutes, and further comprise: at first the Radix Sophorae Flavescentis of 20 weight portions, the Herba Portulacae of 15 weight portions, the Semen Coicis of 30 weight portions, the Fructus Kochiae of 15 weight portions and the Cortex Phellodendri of 15 weight portions are mixed with water, be heated to water and boiled lasting 25-45 minute afterwards; And and then add the Herba Violae of 10 weight portions, the Flos Rosae Chinensis of 15 weight portions, the Rhizoma Chuanxiong of 10 weight portions and the Rhizoma Ligustici of 15 weight portions and add, continue heating 5-10 minute.Thus, the medicine that contains said ratio Chinese medicine can be with the drug effect between the optimal compatibility relationship coordinating the actions of various ingredients in a prescription, thereby improves the effect for the treatment of steroid-dependent dermatitis more significantly.
According to embodiments of the invention, adopt 60～80 purpose medicines sieve that the decocting for Chinese herbal medicine medicinal liquid that obtains is filtered.Thus, can be by filter removing the medicinal residues in the decocting for Chinese herbal medicine liquid that obtains, obtains other compositions in the decocting for Chinese herbal medicine liquid thereby reduce institute, thereby the effect of steroid-dependent dermatitis is treated in raising.
According to embodiments of the invention, the method that adopts reduced-pressure backflow is to concentrating through the decocting for Chinese herbal medicine liquid that filters, thereby decocting for Chinese herbal medicine liquid is concentrated into the concentration of suitable formulations, reduces the difficulty of follow-up preparation operation, can reach medicinal concentration requirement again simultaneously.The discovery that the inventor is surprised, to be concentrated into the concentration that every milliliter of medicinal liquid contains the 1g crude drug through the decocting for Chinese herbal medicine liquid that filters, namely can add easily and in follow-up formulation preparation process, mix with pharmaceutical excipient, can reach the concentration requirement of the pharmaceutical formulation for the treatment of steroid-dependent dermatitis again, thereby improve the effect for the treatment of steroid-dependent dermatitis.
According to embodiments of the invention, described Chinese medicine preparation is through gastrointestinal administration dosage form and non-through the gastrointestinal administration dosage form.Thus, can make suitable medicinal Chinese medicine preparation with various suitable forms with containing Chinese medicine composition of the present invention, thereby improve the effect for the treatment of steroid-dependent dermatitis.
According to embodiments of the invention, described Chinese medicine preparation is at least a form that is selected from capsule, pill, tablet, granule, liquid oral, oral pastes, suppository, externally used paste, external-use lotion, liniment, aerosol and spray.Thus, the Chinese medicine preparation that contains Chinese medicine composition of the present invention can be carried out administration in various suitable modes, thereby improve the effect for the treatment of steroid-dependent dermatitis.
According to a particular embodiment of the invention, this Chinese medicine preparation can further comprise minor amounts of auxiliary substances, for example wetting agent or emulsifying agent, antiseptic or buffer, and described auxiliary substance can strengthen pot-life or the effectiveness of pharmaceutical composition.Pass through embodiments of the invention, the mode of sending this pharmaceutical composition is unrestricted, can adopt known various delivery systems, as long as can use the middle preparation of the Chinese medicine composition that contains the embodiment of the invention effectively, improve the effect for the treatment of steroid-dependent dermatitis.
Term as used herein " pharmaceutically acceptable excipient " can comprise any pharmaceutically operable common excipient, for example includes but not limited to binding agent, filler, is coated with membrane polymer, plasticizer, fluidizer, disintegrating agent, lubricant etc.
Additional aspect of the present invention and advantage part in the following description provide, and part will become obviously from the following description, or recognize by practice of the present invention.
The specific embodiment
Below by specific embodiment, the present invention will be described.Need to prove that the following example only is schematically, and does not limit the present invention in any way.
Embodiment 1
Take by weighing the Radix Sophorae Flavescentis decoction pieces of 25 weight portions, the Herba Portulacae decoction pieces of 20 weight portions, the Semen Coicis decoction pieces of 35 weight portions, the Fructus Kochiae decoction pieces of 20 weight portions, the Cortex Phellodendri decoction pieces of 20 weight portions, the Herba Violae decoction pieces of 15 weight portions, the Flos Rosae Chinensis decoction pieces of 20 weight portions, the Rhizoma Chuanxiong decoction pieces of 15 weight portions and the Rhizoma Ligustici decoction pieces of 20 weight portions.Radix Sophorae Flavescentis decoction pieces to aforementioned 35 weight portions that take by weighing, the Herba Portulacae decoction pieces of 20 weight portions, the Semen Coicis decoction pieces of 25 weight portions, the clear water that adds 75 weight portions in the mixture of the Fructus Kochiae decoction pieces of 20 weight portions and the Cortex Phellodendri decoction pieces of 20 weight portions, and in soaking at room temperature half an hour, after being heated to boiling with intense fire then, transfer slow fire heating 35 minutes to, the Herba Violae decoction pieces that then adds 15 weight portions again, the Flos Rosae Chinensis decoction pieces of 20 weight portions, the Rhizoma Chuanxiong decoction pieces of 15 weight portions and the Rhizoma Ligustici decoction pieces of 20 weight portions transfer moderate heat heating 10 minutes to, the decoction liquor that obtains is filtered, concentrate, make Chinese medicine preparation A with mixed with excipients then.
Embodiment 2
Take by weighing the Radix Sophorae Flavescentis decoction pieces of 15 weight portions, the Herba Portulacae decoction pieces of 15 weight portions, the Semen Coicis decoction pieces of 25 weight portions, the Fructus Kochiae decoction pieces of 15 weight portions, the Cortex Phellodendri decoction pieces of 10 weight portions, the Herba Violae decoction pieces of 5 weight portions, the Flos Rosae Chinensis decoction pieces of 10 weight portions, the Rhizoma Chuanxiong decoction pieces of 10 weight portions and the Rhizoma Ligustici decoction pieces of 12 weight portions.Radix Sophorae Flavescentis decoction pieces to aforementioned 15 weight portions that take by weighing, the Herba Portulacae decoction pieces of 15 weight portions, the Semen Coicis decoction pieces of 25 weight portions, the clear water that adds 30 weight portions in the mixture of the Fructus Kochiae decoction pieces of 15 weight portions and the Cortex Phellodendri decoction pieces of 10 weight portions, and in soaking at room temperature half an hour, after being heated to boiling with intense fire then, transfer slow fire heating 25 minutes to, the Herba Violae decoction pieces that then adds 5 weight portions again, the Flos Rosae Chinensis decoction pieces of 10 weight portions, the Rhizoma Chuanxiong decoction pieces of 10 weight portions and the Rhizoma Ligustici decoction pieces of 12 weight portions transfer moderate heat heating 5 minutes to, the decoction liquor that obtains is filtered, concentrate, make Chinese medicine preparation B with mixed with excipients then.
Embodiment 3
Take by weighing the Radix Sophorae Flavescentis decoction pieces of 20 weight portions, the Herba Portulacae decoction pieces of 15 weight portions, the Semen Coicis decoction pieces of 30 weight portions, the Fructus Kochiae decoction pieces of 15 weight portions, the Cortex Phellodendri decoction pieces of 15 weight portions, the Herba Violae decoction pieces of 10 weight portions, the Flos Rosae Chinensis decoction pieces of 15 weight portions, the Rhizoma Chuanxiong decoction pieces of 10 weight portions and the Rhizoma Ligustici decoction pieces of 15 weight portions.Radix Sophorae Flavescentis decoction pieces to aforementioned 20 weight portions that take by weighing, the Herba Portulacae decoction pieces of 15 weight portions, the Semen Coicis decoction pieces of 30 weight portions, the clear water that adds 50 weight portions in the mixture of the Fructus Kochiae decoction pieces of 15 weight portions and the Cortex Phellodendri decoction pieces of 15 weight portions, and in soaking at room temperature half an hour, after being heated to boiling with intense fire then, transfer slow fire heating 40 minutes to, the Herba Violae decoction pieces that then adds 10 weight portions again, the Flos Rosae Chinensis decoction pieces of 15 weight portions, the Rhizoma Chuanxiong decoction pieces of 10 weight portions and the Rhizoma Ligustici decoction pieces of 15 weight portions transfer moderate heat heating 8 minutes to, the decoction liquor that obtains is filtered, concentrate, make Chinese medicine preparation B with mixed with excipients then.
Embodiment 4 toxicological tests
Laboratory animal is Kunming mouse, New Zealand white family members, and two kinds of animals provide by Beijing Uniliver zoopery center.
1. acute toxicity test: medicine gastric infusion, lumbar injection or externally occur poisoning in 7 days when smearing consumption and reaching 100g/kg or dead.
2. long-term skin toxicology test: animal is divided into 5 groups: Chinese medicine preparation A group, Chinese medicine preparation B group, Chinese medicine preparation C group, do not use blank group and the Pevisone positive controls of medicine, after exposing animal skin, the consumption of smearing of medicine A, medicine B, medicine C and positive drug is 10g/kg/day, and the blank group is smeared normal saline every day.Administration 21 days, 5 treated animals all do not occur poisoning or are dead.At the 22nd day with sacrifice of animal, the heart, liver, lung, stomach, adrenal gland, testis, ovary, uterus and skin (medicinal district, not medication district and intersection) are carried out pathological anatomy and biopsy tissues to be learned and checks, having compared the unusual histology of troops with the blank group of not using medicine changes, punctation appears in the skin of positive drug treated animal, individual animal is because phenomenons such as skin breakdown, infection appear in scratching, and because deterioration has appearred in the continuation medication.Thus, shown that the advantage of untoward reaction and histology infringement can not appear in Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C long-term prescription.
The experiment of embodiment 5 antiallergic
Mice is divided into 5 groups: Chinese medicine preparation A group, Chinese medicine preparation B group, Chinese medicine preparation C organize, do not use blank group and the Pevisone positive controls of medicine, medicine A, medicine B, medicine C and positive drug are irritated stomach to mice respectively with the dosage of 20g/kg, the blank group gives normal saline, give mice intradermal injection histamine simultaneously, observe medicine to the inhibitory action of the caused dermoreaction of histamine.By experimental result as can be known, compare with the blank group of not medication, Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C and positive drug are respectively 40.8%, 65.7%, 36.7% and 28.6% to the inhibitory action of the dermoreaction that histamine causes.
Mice is divided into 5 groups: Chinese medicine preparation A group, Chinese medicine preparation B group, Chinese medicine preparation C organize, do not use blank group and the Pevisone positive controls of medicine, Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C and positive drug are irritated stomach to mice respectively with the dosage of 20g/kg, the blank group gives normal saline, give mice intradermal injection specificity trichosanthin simultaneously, observe medicine to the anaphylactoid inhibitory action of antigenic type.By experimental result as can be known, compare with the blank group of not medication, Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C and positive drug are respectively 38.7%, 66.3%, 31.5 and 29.1% to the inhibitory action of the dermoreaction that the specificity trichosanthin causes.
Thus, two experiments have shown that specificity and the non-specific skin allergy of Chinese medicine preparation A, Chinese medicine preparation B, the local skin of Chinese medicine preparation C all have inhibitory action, and are better than the inhibitory action of positive control drug, are optimum with the drug effect of Chinese medicine preparation B.
The experiment of embodiment 6 antiinflammatories
Mice is divided into 5 groups: Chinese medicine preparation A group, Chinese medicine preparation B group, Chinese medicine preparation C organize, do not use blank group and the Pevisone positive controls of medicine, at first adopt dimethylbenzene to set up the mice ear model, then with the dosage of the 10g/kg ear that spreads upon mice swelling with medicine A, medicine B, medicine C and positive drug, the blank group is smeared normal saline, observes medicine causes swelling to inflammation inhibitory action.By experimental result as can be known, compare with the blank group of not medication, the inhibitory action highly significant of the ear swelling that Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C xylol cause is weighed and data analysis obtains Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C and positive drug the suppression ratio of mice ear is respectively 37.4%, 58.9%, 25.7% and 24.3% through punching.
Rat is divided into 5 groups: Chinese medicine preparation A group, Chinese medicine preparation B group, Chinese medicine preparation C organize, do not use blank group and the Pevisone positive controls of medicine, at first Freund's complete adjuvant is injected into rat foot subcutaneous tissue and sets up the toes inflammatory model, with the dosage of 10g/kg Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C and positive drug be coated in the rat foot then, blank group coating normal saline is observed medicine causes swelling to inflammation inhibitory action.By experimental result as can be known, compare with the blank group of not medication, the inhibitory action highly significant of the foot swelling that Chinese medicine preparation A, Chinese medicine preparation B, the Freund's complete adjuvant of Chinese medicine preparation C cause, through measure and data analysis obtain Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C and positive drug to week of the toes inflammation of rat directly and thickness significant inhibitory effect is arranged, suppression ratio is respectively 38.4%, 57.2%, 28.8% and 25.5%.
Thus, more than two result of experiment shown that Chinese medicine preparation A, Chinese medicine preparation B, Chinese medicine preparation C external can alleviate scytitis significantly, and effect is better than the positive drug group, is optimum with the drug effect of Chinese medicine preparation B.
Embodiment 7 clinical cases
Zhao XX, woman, nonallergic body constitution, not find that etiology is arranged, cause a disease because of, the skin pruritus is more than, in order to alleviate pruritus, external hormone cream fluocinonide is smeared voluntarily, after smearing, just takes effect very soon in a short time, the skin pruritus symptom occurs again after the drug withdrawal, 15 years repeatedly, after use Chinese medicine preparation B smeared 1 month, symptom was alleviated gradually, after the treatment of 3 courses for the treatment of, no longer recurrence.
Open XX, the man, pubarche, constantly grown small pox on the face, adopt the hormones externally-applied ointment to be coated with applying treatment, but also to no effect, through after a while, pore is thicker, erythema around the cheek is more and more, does not find the method for radical cure for many years, uses Chinese medicine preparation B to smear, face's situation has had change behind the one and a half months, face's erythema becomes not obvious, and skin has also recovered elasticity, and small pox has thoroughly disappeared.
Lee XX, woman, allergic constitution, spring or the face of changing according to the season, ancon decortication, long small pox, the appearance symptom applies PIYANPING voluntarily can be alleviated, and behind the life-time service PIYANPING has been produced dependence, after use Chinese medicine preparation B smears, the skin exquisiteness is recovered elasticity, the recurrence situation do not occur.
In the description of this description, concrete feature, structure, material or characteristics that the description of reference term " embodiment ", " some embodiment ", " example ", " concrete example " or " some examples " etc. means in conjunction with this embodiment or example description are contained at least one embodiment of the present invention or the example.In this manual, the schematic statement to above-mentioned term not necessarily refers to identical embodiment or example.And concrete feature, structure, material or the characteristics of description can be with the suitable manner combination in any one or more embodiment or example.
Although illustrated and described embodiments of the invention above, be understandable that, above-described embodiment is exemplary, can not be interpreted as limitation of the present invention, those of ordinary skill in the art can change above-described embodiment under the situation that does not break away from principle of the present invention and aim within the scope of the invention, modification, replacement and modification.
Claims (10)
1. a Chinese medicine preparation for the treatment of steroid-dependent dermatitis is characterized in that, comprising:
Chinese medicine composition, described Chinese medicine composition comprises:
The Radix Sophorae Flavescentis of 15～25 weight portions;
The Herba Portulacae of 15～20 weight portions;
The Semen Coicis of 25～35 weight portions;
The Fructus Kochiae of 15～20 weight portions;
The Cortex Phellodendri of 10～20 weight portions;
The Herba Violae of 5～15 weight portions;
The Flos Rosae Chinensis of 10～20 weight portions;
The Rhizoma Chuanxiong of 10～15 weight portions;
The Rhizoma Ligustici of 12～20 weight portions,
Pharmaceutically acceptable excipient.
2. Chinese medicine for external application according to claim 1 is characterized in that, described Chinese medicine composition comprises:
The Radix Sophorae Flavescentis of 20 weight portions;
The Herba Portulacae of 15 weight portions;
The Semen Coicis of 30 weight portions;
The Fructus Kochiae of 15 weight portions;
The Cortex Phellodendri of 15 weight portions;
The Herba Violae of 10 weight portions;
The Flos Rosae Chinensis of 15 weight portions;
The Rhizoma Chuanxiong of 10 weight portions; And
The Rhizoma Ligustici of 15 weight portions.
3. a method for preparing the Chinese medicine preparation of the described treatment steroid-dependent dermatitis of claim 1 is characterized in that, may further comprise the steps:
Supply raw materials according to following ratio: the Herba Violae of the Fructus Kochiae of the Herba Portulacae of the Radix Sophorae Flavescentis of 15～25 weight portions, 15～20 weight portions, the Semen Coicis of 25～35 weight portions, 15～20 weight portions, the Cortex Phellodendri of 10～20 weight portions, 5～15 weight portions, the Flos Rosae Chinensis of 10～20 weight portions, the Rhizoma Chuanxiong of 10～15 weight portions and the Rhizoma Ligustici of 12～20 weight portions, in order to obtain raw mix;
Resulting raw mix is added to the water, decocted 30～50 minutes, in order to obtain the decocting for Chinese herbal medicine medicinal liquid;
Described decocting for Chinese herbal medicine medicinal liquid is filtered, concentrates, in order to obtain concentrated solution; And
Described concentrated solution is mixed with described pharmaceutically acceptable excipient, in order to obtain described Chinese medicine preparation.
4. method according to claim 3, it is characterized in that, supply raw materials according to following ratio: the Herba Violae of the Fructus Kochiae of the Herba Portulacae of the Radix Sophorae Flavescentis of 20 weight portions, 15 weight portions, the Semen Coicis of 30 weight portions, 15 weight portions, the Cortex Phellodendri of 15 weight portions, 10 weight portions, the Flos Rosae Chinensis of 15 weight portions, the Rhizoma Chuanxiong of 10 weight portions and the Rhizoma Ligustici of 15 weight portions.
5. according to claim 3 or 4 described methods, it is characterized in that based on the weight of described Radix Sophorae Flavescentis, the use amount of water and the weight ratio of Radix Sophorae Flavescentis are 500:15～25.
6. method according to claim 5 is characterized in that, resulting raw mix is added to the water, and decocts 30～50 minutes, and further comprises:
At first the Radix Sophorae Flavescentis of 20 weight portions, the Herba Portulacae of 15 weight portions, the Semen Coicis of 30 weight portions, the Fructus Kochiae of 15 weight portions and the Cortex Phellodendri of 15 weight portions are mixed with water, be heated to water and boiled lasting 25-45 minute afterwards; And
Then, add the Herba Violae of 10 weight portions, the Flos Rosae Chinensis of 15 weight portions, the Rhizoma Chuanxiong of 10 weight portions and the Rhizoma Ligustici of 15 weight portions again, continue heating 5-10 minute.
7. method according to claim 3 is characterized in that, adopts 60～80 purpose medicines sieve that the decocting for Chinese herbal medicine medicinal liquid that obtains is filtered.
8. method according to claim 3 is characterized in that, adopts the method for reduced-pressure backflow that the decocting for Chinese herbal medicine liquid through filtration is concentrated,
Wherein, will be concentrated into 1g crude drug/mL medicinal liquid through the decocting for Chinese herbal medicine liquid that filters.
9. method according to claim 3 is characterized in that, described Chinese medicine preparation is through gastrointestinal administration dosage form and non-through the gastrointestinal administration dosage form.
10. method according to claim 3, it is characterized in that described Chinese medicine preparation is at least a form that is selected from capsule, pill, tablet, granule, liquid oral, oral pastes, suppository, externally used paste, external-use lotion, liniment, aerosol and spray.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109771344A (en) * | 2018-12-21 | 2019-05-21 | 佛山市南海施乐华化妆品有限公司 | Hormone face remediation composition and preparation method thereof |
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| CN1814218A (en) * | 2005-12-11 | 2006-08-09 | 赵桂荣 | Hormone external-dressing agent for treating dermatitis |
| CN101274093A (en) * | 2008-05-06 | 2008-10-01 | 广冬云 | Chinese medicine for curing fungal dermatopathy |
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- 2013-06-24 CN CN2013102536502A patent/CN103341078A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814218A (en) * | 2005-12-11 | 2006-08-09 | 赵桂荣 | Hormone external-dressing agent for treating dermatitis |
| CN101274093A (en) * | 2008-05-06 | 2008-10-01 | 广冬云 | Chinese medicine for curing fungal dermatopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109771344A (en) * | 2018-12-21 | 2019-05-21 | 佛山市南海施乐华化妆品有限公司 | Hormone face remediation composition and preparation method thereof |
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Application publication date: 20131009 |