CN103316294B - Be used for the treatment of the pharmaceutical composition of acne - Google Patents

Abstract

The present invention relates to the pharmaceutical composition and application thereof that are used for the treatment of acne, be made up of following crude drug: Radix Glycyrrhizae 2-4 part, Radix Paeoniae Alba 2-4 part, Herba Salviae Chinensis 1.5-2 part, Radix Curcumae 1-1.5 part, Cortex Albiziae 1-1.5 part.The invention has the advantages that: provide a kind of new pharmaceutical compositions being used for the treatment of acne, have very remarkable and stable effect for Acne treatment; Flavour of a drug number is less, and is all conventional Chinese medicine, and preparation technology is also very simple, rapid-action, short treating period, and cost is extremely low, greatly reduces the burden of patient; Have no side effect, be suitable for extensive popularization.

Description

Pharmaceutical composition for treating acne

technical field

The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating acne.

Background technique

Acne removal is the process of using medical technology or methods to eliminate acne. Acne is a common name for acne, also known as "acne", "acne" or "acne", which is a skin disease caused by blockage and inflammation of hair follicles and sebaceous glands. . During puberty, the hormones in the body will stimulate hair growth and promote the sebaceous glands to secrete more oil, so the hair and sebaceous glands will accumulate a lot of substances, making the oil and bacteria adhere, causing skin redness and swelling. Because this symptom is common in young men and women, it is called "acne". In fact, not all teenagers will have acne, and acne does not necessarily only occur on teenagers.

At present, the external use of traditional Chinese medicine and western medicine plaster is a palliative treatment for acne, and the deficiency of internal medicine Chinese and Western medicine treatment is high recurrence rate, many adverse reactions, and high treatment costs. Internal medicine Chinese medicine treatment of acne has achieved certain results. Most of them lay particular stress on one side, the universality is not strong, the effect is not obvious, and the number of medicine flavors is many, and the treatment cycle is long, so far there is no medicine that is generally applicable and can fundamentally cure acne.

Contents of the invention

The object of the present invention is to provide a pharmaceutical composition for treating acne aiming at the deficiencies in the prior art.

Another object of the present invention is to provide another pharmaceutical composition for treating acne.

Another object of the present invention is to provide the application of the pharmaceutical composition for treating acne.

In order to achieve the above object, the technical solution adopted by the present invention is: a pharmaceutical composition for treating acne, made of the following crude drugs in parts by weight: 2-4 parts of Radix Glycyrrhizae, 2-4 parts of Radix Paeoniae Alba, 1.5-4 parts of Ishijian Chuan 2 parts, 1-1.5 parts of turmeric, 1-1.5 parts of acacia skin.

Preferably, it is prepared from the following raw materials by weight: 2 parts of licorice, 2 parts of white peony root, 1.5 parts of Ishimichuan, 1 part of curcuma, and 1.5 parts of bark of Albizia juniperus.

Preferably, it is prepared from the following raw materials in parts by weight: 3 parts of licorice, 3 parts of white peony root, 1.8 parts of Shi Jianchuan, 1.2 parts of turmeric, and 1.2 parts of bark of Albizia juniperus.

Preferably, it is prepared from the following raw materials in parts by weight: 4 parts of licorice, 4 parts of white peony, 2 parts of Ishimichuan, 1.5 parts of turmeric, and 1 part of bark of Albizia juniper.

In order to achieve the above-mentioned second purpose, the technical solution adopted by the present invention is: a pharmaceutical composition for treating acne, made of the following raw materials in parts by weight: 3 parts of Radix Glycyrrhizae, 3 parts of Radix Paeoniae Alba, 1.8 parts of Shi Jianchuan, 1.2 parts of turmeric, 1.2 parts of Albizia juniper, 1 part of hawthorn, 2 parts of Qingfengteng, 1 part of angelica, 1 part of herb, 2 parts of Angelica dahurica, 2 parts of ephedra, 1.5 parts of seaweed, 2 parts of Codonopsis, 1 part of Atractylodes macrocephala, and 1.5 parts of raw land 2 servings, 2 servings of Panax notoginseng, 3 servings of golden buckwheat.

In order to achieve the third objective above, the technical solution adopted by the present invention is: the application of the pharmaceutical composition in the preparation of acne-removing medicine.

The present invention has the advantage that:

1. A new pharmaceutical composition for treating acne is provided, which has a significant and stable effect on treating acne;

2. The number of medicinal flavors is small, and they are all commonly used traditional Chinese medicines. The preparation process is also very simple, the effect is fast, the course of treatment is short, and the cost is extremely low, which greatly reduces the burden on patients;

3. It has no toxic and side effects and is suitable for wide promotion.

Detailed ways

The specific implementation modes provided by the present invention will be described in detail below in conjunction with the examples.

Example 1

2 parts of licorice, 2 parts of white peony, 1.5 parts of Shi Jianchuan, 1 part of turmeric, and 1.5 parts of Albizia juniper. The conventional method is decocted into a decoction.

Example 2

3 parts of licorice, 3 parts of white peony, 1.8 parts of Shi Jianchuan, 1.2 parts of turmeric, and 1.2 parts of Albizia bark. The conventional method is decocted into a decoction.

Example 3

4 parts of licorice, 4 parts of white peony, 2 parts of Shi Jianchuan, 1.5 parts of turmeric, and 1 part of Albizia bark. The conventional method is decocted into a decoction.

Example 4

2.5 parts of licorice, 2.5 parts of white peony, 1.6 parts of Shi Jianchuan, 1.3 parts of turmeric, and 1.3 parts of Albizia bark. The conventional method is decocted into a decoction.

Example 5

3.5 parts of licorice, 3.5 parts of white peony, 1.9 parts of Shi Jianchuan, 1.3 parts of turmeric, and 1.3 parts of Albizia juniper. The conventional method is decocted into a decoction.

Embodiment 6 clinical experiment

1. Case selection

60 patients with facial acne vulgaris had typical clinical manifestations, met the diagnostic criteria of acne vulgaris and acne, did not take any drug treatment within one month, and were not associated with other diseases. Randomly divided into two groups, two groups of disease, age, no significant difference, comparable.

Test group: take the traditional Chinese medicine decoction prepared according to Example 2 (containing crude drug content 1.0g/mL), once in the morning and in the evening, 200mL each time, 7 days as a course of treatment, a total of 4 courses of treatment.

Control group: taking the decoction of traditional Chinese medicine prepared according to the method of Example 2 (containing 1.0 g/mL of crude drug), wherein the raw material of Chinese medicine does not contain Shi Jianchuan, that is, 3 parts of licorice, 3 parts of white peony root, and 1.2 parts of curcuma , 1.2 parts of acacia skin. Once in the morning and evening, 200mL each time, 7 days as a course of treatment, a total of 4 courses of treatment.

2. Evaluation criteria

Significantly effective: facial acne healed, no new red papules, and clinical symptoms disappeared.

Effective: facial acne basically healed, no new red papules, and clinical symptoms basically disappeared.

Ineffective: Facial acne and clinical symptoms have not changed significantly before treatment, and there are still new red papules.

3. Efficacy results

See Table 1 below. The curative effect results show that the pharmaceutical composition for treating acne of the present invention has a significant therapeutic effect on acne. Not only does it take effect quickly, but the effective rate reaches 83.3% in the first week, and the cure rate is high. After 4 weeks of treatment, it reaches 83.3%. 100% effective. Although the other four medicines in the control group had the same composition ratio as the test group, the curative effect was greatly reduced because Shi Jianchuan was not added, and the effective rate reached 43.3% after 4 weeks of treatment. There is no clinical report of Shi Jianchuan in treating acne. However, the curative effect of the pharmaceutical composition of the present invention shows that the combination of Shi Jianchuan and other four herbs of the present invention shows a strong synergistic effect, so that the present invention can effectively cure acne. No adverse reactions were found in the two groups.

Table 1 Efficacy results

In the test, the therapeutic effects of the proportions of Examples 1-5 were also counted respectively. After 4 weeks of treatment, the effective rates were respectively 91%, 100%, 92%, 85%, and 80%. The results showed that Example 3 The raw material drug ratio therapeutic effect is the best, followed by embodiment 1 and 2.

Example 7

   In the course of the experiment, the inventor also investigated another group of prescriptions with more medicinal flavors, namely: 3 parts of licorice, 3 parts of white peony, 1.8 parts of Shi Jianchuan, 1.2 parts of turmeric, 1.2 parts of Albizia juniper, and 1 part of hawthorn , Qingfengteng 2 parts, Angelica 1 part, Atractylodes 1 part, Angelica dahurica 2 parts, Ephedra 2 parts, Seaweed 1.5 parts, Codonopsis 2 parts, Atractylodes macrocephala 1 part, Rehmannia 1.5 parts, Panax notoginseng 2 parts, Golden Buckwheat 3 parts. Take traditional Chinese medicine decoction (containing 1.0g/mL of crude drug) prepared by conventional methods, once in the morning and evening, 200mL each time, 7 days as a course of treatment, a total of 4 courses of treatment.

The test results show that this Chinese medicine formula can also achieve 100% effective rate after 4 weeks, and compared with the formula ratio of Example 2, patients who use the former formula not only have their acne cured, but also significantly reduce facial scars ( 70%), and also has some whitening effect (60%), which shows that although this prescription has more medicinal flavors, it not only has a good acne treatment effect, but also has the effect of lightening scars and whitening.

Claims (1)

1. The pharmaceutical composition for treating acne is characterized in that it is made of the following crude drugs in parts by weight: 3 parts of Radix Glycyrrhizae, 3 parts of Radix Paeoniae Alba, 1.8 parts of Shi Jianchuan, 1.2 parts of Curcuma, 1.2 parts of Albizia Julibrissin, Hawthorn 1, Qingfengteng 2, Angelica 1, Atractylodes 1, Angelica 2, Ephedra 2, Seaweed 1.5, Codonopsis 2, Atractylodes 1, Rehmannia 1.5, Panax notoginseng 2, Golden buckwheat 3 share.