CN103316294B - Be used for the treatment of the pharmaceutical composition of acne - Google Patents
Be used for the treatment of the pharmaceutical composition of acne Download PDFInfo
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- CN103316294B CN103316294B CN201310230188.4A CN201310230188A CN103316294B CN 103316294 B CN103316294 B CN 103316294B CN 201310230188 A CN201310230188 A CN 201310230188A CN 103316294 B CN103316294 B CN 103316294B
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Abstract
The present invention relates to the pharmaceutical composition and application thereof that are used for the treatment of acne, be made up of following crude drug: Radix Glycyrrhizae 2-4 part, Radix Paeoniae Alba 2-4 part, Herba Salviae Chinensis 1.5-2 part, Radix Curcumae 1-1.5 part, Cortex Albiziae 1-1.5 part.The invention has the advantages that: provide a kind of new pharmaceutical compositions being used for the treatment of acne, have very remarkable and stable effect for Acne treatment; Flavour of a drug number is less, and is all conventional Chinese medicine, and preparation technology is also very simple, rapid-action, short treating period, and cost is extremely low, greatly reduces the burden of patient; Have no side effect, be suitable for extensive popularization.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically, is a kind of pharmaceutical composition being used for the treatment of acne.
Background technology
Anti-acne is the process using Medical Technology or method to eliminate comedo; Pox is being commonly called as of acne, is again " comedo ", " skin sore " or " acne ", is a kind of dermatosis because hair follicle and sebaceous gland are blocked, inflammation causes.During adolescence, the hormone meeting stimulating hair growth in body, promote smegma more heavy wool fat, therefore hair and sebaceous gland pile up many materials, make oils and fats and bacterial adhesion, cause the reaction of red swelling of the skin.Because this symptom is common in youth of both sexes, so just claim it to be " comedo ".In fact, teenager not necessarily all can long comedo, and comedo is also not necessarily only long with it teen-age.
Current Chinese and western medicine externally applied ointment to the treatment of acne for taking stopgap measures, and the deficiency of oral medicine integrative therapy to be relapse rate high, untoward reaction is many, medical expense is high, oral medicine Chinese traditional treatment acne has achieved certain effect, but existing medicine is laid particular stress on unilaterally mostly, universality is not strong, DeGrain, and flavour of a drug number is more, treatment cycle is long, there is no one so far and is generally suitable for, and fundamentally can cure the medicine of acne.
Summary of the invention
The object of the invention is, for deficiency of the prior art, to be provided for the pharmaceutical composition of Acne treatment.
Of the present invention again one object be provide another kind to be used for the treatment of the pharmaceutical composition of acne.
Another object of the present invention is provided for the application of the pharmaceutical composition of Acne treatment.
For achieving the above object, the technical scheme that the present invention takes is: the pharmaceutical composition being used for the treatment of acne, is made up of the crude drug of following weight portion: Radix Glycyrrhizae 2-4 part, Radix Paeoniae Alba 2-4 part, Herba Salviae Chinensis 1.5-2 part, Radix Curcumae 1-1.5 part, Cortex Albiziae 1-1.5 part.
Preferably be made up of the crude drug of following weight portion: 2 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 2 parts, Herba Salviae Chinensis 1.5 parts, Radix Curcumae 1 part, Cortex Albiziae 1.5 parts.
Preferably be made up of the crude drug of following weight portion: 3 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3 parts, Herba Salviae Chinensis 1.8 parts, Radix Curcumae 1.2 parts, Cortex Albiziae 1.2 parts.
Preferably be made up of the crude drug of following weight portion: 4 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 4 parts, Herba Salviae Chinensis 2 parts, Radix Curcumae 1.5 parts, Cortex Albiziae 1 part.
For realizing above-mentioned second object, the technical scheme that the present invention takes is: the pharmaceutical composition being used for the treatment of acne, is made up of the crude drug of following weight portion: 3 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3 parts, Herba Salviae Chinensis 1.8 parts, Radix Curcumae 1.2 parts, Cortex Albiziae 1.2 parts, Fructus Crataegi 1 part, Caulis Sinomenii 2 parts, Radix Angelicae Sinensis 1 part, Rhizoma Atractylodis 1 part, the Radix Angelicae Dahuricae 2 parts, 2 parts, Herba Ephedrae, Sargassum 1.5 parts, Radix Codonopsis 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part, 1.5 parts, the Radix Rehmanniae, Radix Notoginseng 2 parts, Rhizoma Fagopyri Dibotryis 3 parts.
For realizing above-mentioned 3rd object, the technical scheme that the present invention takes is: the application of described pharmaceutical composition in preparation anti-acne medicine.
The invention has the advantages that:
1, provide a kind of new pharmaceutical compositions being used for the treatment of acne, have very remarkable and stable effect for Acne treatment;
2, flavour of a drug number is less, and is all conventional Chinese medicine, and preparation technology is also very simple, rapid-action, short treating period, and cost is extremely low, greatly reduces the burden of patient;
3, have no side effect, be suitable for extensive popularization.
Detailed description of the invention
Below in conjunction with embodiment, detailed description of the invention provided by the invention is elaborated.
embodiment 1
2 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 2 parts, Herba Salviae Chinensis 1.5 parts, Radix Curcumae 1 part, Cortex Albiziae 1.5 parts.Conventional method decocts into decoction.
embodiment 2
3 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3 parts, Herba Salviae Chinensis 1.8 parts, Radix Curcumae 1.2 parts, Cortex Albiziae 1.2 parts.Conventional method decocts into decoction.
embodiment 3
4 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 4 parts, Herba Salviae Chinensis 2 parts, Radix Curcumae 1.5 parts, Cortex Albiziae 1 part.Conventional method decocts into decoction.
embodiment 4
2.5 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 2.5 parts, Herba Salviae Chinensis 1.6 parts, Radix Curcumae 1.3 parts, Cortex Albiziae 1.3 parts.Conventional method decocts into decoction.
embodiment 5
3.5 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3.5 parts, Herba Salviae Chinensis 1.9 parts, Radix Curcumae 1.3 parts, Cortex Albiziae 1.3 parts.Conventional method decocts into decoction.
embodiment 6 clinical experiment
1. case selection
Face acne vulgaris patient 60 example, has typical clinical manifestation, meets the diagnostic criteria of acne vulgaris, comedo, do not make any Drug therapy in one month, without merging other diseases.Be divided into two groups at random, two groups of state of an illness, ages etc., without significant difference, have comparability.
Test group: take the Chinese medicine decoction (containing crude drug amount 1.0g/mL) prepared according to embodiment 2, sooner or later respectively once, each 200mL 7 days is a course for the treatment of, takes 4 courses for the treatment of altogether.
Matched group: take the decocting for Chinese herbal medicine liquid (containing crude drug amount 1.0g/mL) prepared according to embodiment 2 method, does not wherein contain Herba Salviae Chinensis, i.e. 3 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3 parts, Radix Curcumae 1.2 parts, Cortex Albiziae 1.2 parts in raw material of Chinese medicine medicine.Sooner or later respectively once, each 200mL 7 days is a course for the treatment of, takes 4 courses for the treatment of altogether.
2. evaluation criterion
Effective: facial area acne heals, send out red papules, clinical symptom disappearance without new.
Effective: facial area acne heals substantially, send out red papules without new, clinical symptoms disappears substantially.
Invalid: without obviously changing before facial area acne and clinical symptoms and treatment, to still have a newly red papules.
3. efficacy result
See the following form 1.Efficacy result shows, and the pharmaceutical composition being used for the treatment of acne of the present invention has significant therapeutic effect to acne, not only rapid-action, and within the 1st week, effective percentage just reaches 83.3%, and cure rate is high, reaches the effective percentage of 100% after treating 4 weeks especially.Although other four Chinese medicines of matched group are identical with test group proportion of composing, but owing to not adding Herba Salviae Chinensis, curative effect is had a greatly reduced quality, treat effective percentage after 4 weeks and just reach 43.3%, Herba Salviae Chinensis there is no the report of Acne treatment clinically, but pharmaceutical composition curative effect display of the present invention, Herba Salviae Chinensis and other four Chinese medicines of the present invention share and show very strong synergism, make the present invention effectively can cure acne.Two groups all do not find untoward reaction.
Table 1 efficacy result
The therapeutic effect adopting the ratio of embodiment 1-5 respectively has also been added up respectively in test, in treatment after 4 weeks, effective percentage is respectively 91%, 100%, 92%, 85%, 80%, and result shows, the crude drug proportioning therapeutic effect of embodiment 3 is best, is secondly embodiment 1 and 2.
embodiment 7
inventor is in process of the test, also investigate another prescription that flavour of a drug number is more, that is: 3 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3 parts, Herba Salviae Chinensis 1.8 parts, Radix Curcumae 1.2 parts, Cortex Albiziae 1.2 parts, Fructus Crataegi 1 part, Caulis Sinomenii 2 parts, Radix Angelicae Sinensis 1 part, Rhizoma Atractylodis 1 part, the Radix Angelicae Dahuricae 2 parts, 2 parts, Herba Ephedrae, Sargassum 1.5 parts, Radix Codonopsis 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part, 1.5 parts, the Radix Rehmanniae, Radix Notoginseng 2 parts, Rhizoma Fagopyri Dibotryis 3 parts.Take Chinese medicine decoction (containing crude drug amount 1.0g/mL) prepared by conventional method, sooner or later respectively once, each 200mL 7 days is a course for the treatment of, takes 4 courses for the treatment of altogether.
Result of the test shows, this Chinese medicinal formulae also can reach the effective percentage of 100% after 4 weeks, and compare the prescription proportioning of embodiment 2, adopt the patient of the former prescription not only acne obtain healing, face scar also obviously subtracts light (70%), also has part whitening effect (60%), although it is more to show this prescription flavour of a drug number simultaneously, but not only there is good acne treatment effect, also have the effect of desalination cicatrix and whitening concurrently.
Claims (1)
1. be used for the treatment of the pharmaceutical composition of acne, it is characterized in that, be made up of the crude drug of following weight portion: 3 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 3 parts, Herba Salviae Chinensis 1.8 parts, Radix Curcumae 1.2 parts, Cortex Albiziae 1.2 parts, Fructus Crataegi 1 part, Caulis Sinomenii 2 parts, Radix Angelicae Sinensis 1 part, Rhizoma Atractylodis 1 part, the Radix Angelicae Dahuricae 2 parts, 2 parts, Herba Ephedrae, Sargassum 1.5 parts, Radix Codonopsis 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part, 1.5 parts, the Radix Rehmanniae, Radix Notoginseng 2 parts, Rhizoma Fagopyri Dibotryis 3 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310230188.4A CN103316294B (en) | 2013-06-09 | 2013-06-09 | Be used for the treatment of the pharmaceutical composition of acne |
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| CN201310230188.4A CN103316294B (en) | 2013-06-09 | 2013-06-09 | Be used for the treatment of the pharmaceutical composition of acne |
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| CN103316294B true CN103316294B (en) | 2015-08-19 |
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Inventor after: Yuan Longzhou Inventor before: Li Xiuqin Inventor before: Zhang Hui Inventor before: Ma Yan |
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Effective date of registration: 20150702 Address after: Qidong City, Jiangsu province 226200 Nantong lvsigang Tianfen electric tools trade city comprehensive building Applicant after: Qidong Tianfen Electric Tool Technology Innovation Center Address before: 111, room 8-6, building 2, middle Xingang Road, Taicang Port Development Zone, Suzhou, Jiangsu, Applicant before: Taicang Sirui Biotechnology Co., Ltd. |
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