CN103638335B - A kind of Chinese medicine for the treatment of refractory acne and preparation method thereof - Google Patents
A kind of Chinese medicine for the treatment of refractory acne and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of refractory acne and preparation method thereof.This Chinese medicine is made up of following raw material of Chinese medicine medicine: Radix Bupleuri, Ramulus Uncariae Cum Uncis, Flos Chrysanthemi, the Radix Paeoniae Alba, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Concha Ostreae, Os Draconis, Rhizoma Gastrodiae, Periostracum Cicadae, Herba Menthae, Fructus Forsythiae, Cornu Saigae Tataricae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Cortex Moutan, Pheretima, Hirudo, Fructus Citri Sarcodactylis, Fructus Gardeniae, Radix Scutellariae, the Cortex Eucommiae, Herba Leonuri, Herba Taxilli, Caulis Polygoni Multiflori, Poria, Radix Cyathulae, Radix Glycyrrhizae.Chinese medicine of the present invention has depressed liver-energy dispersing and QI regulating, effect of heat clearing and blood circulation promoting, and for obstinate refractory acne, disease sees acne recurrent exerbation, does not unbrokenly heal.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of refractory acne and preparation method thereof.
Background technology
Acne is acne again, is that growth is at the face of people and a kind of inflammatory dermatosis of chest and back.Mostly this sick is to cause due to patient body internal hormone diacrisis if being, its skin lesion can show as pimple, pustule, scleroma and cyst, and patient mostly is and is in hebetic teenager.Generally, most patients with acne is after adolescence, and its state of an illness can be fully recovered voluntarily.But also some patients with acne is after adolescence, its state of an illness still recurrent exerbation, is called refractory acne by this disease clinically.The cause of disease of refractory acne also imperfectly understands at present, and this disease mainly occurs serious endocrine disturbance, repeated infection propionibacterium acnes, vigorous, the frequent edible food pungent, excitatory of smegma or be associated with the factors such as other inflammatory dermatosiss relevant with patient.Refractory acne not only can affect the appearance of patient, leaves ugly cicatrix with it or on the face at it
The medicine of current Acne treatment is numerous, but for refractory acne, also lacks good effect, the medicine not easily recurred after healing.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine for the treatment of refractory acne and preparation method thereof.
The present invention is realized by following technical scheme:
Treat a Chinese medicine for refractory acne, be made up of the raw material of Chinese medicine medicine of following weight:
Radix Bupleuri 3-9 part, Ramulus Uncariae Cum Uncis 6-12 part, Flos Chrysanthemi 6-12 part, Radix Paeoniae Alba 9-15 part, Rhizoma Cyperi 9-15 part, Pericarpium Citri Reticulatae Viride 6-12 part, Concha Ostreae 9-15 part, Os Draconis 9-15 part, Rhizoma Gastrodiae 3-9 part, Periostracum Cicadae 9-15 part, Herba Menthae 9-15 part, Fructus Forsythiae 9-15 part, Cornu Saigae Tataricae 2-4 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Paeoniae Rubra 9-15 part, Cortex Moutan 9-15 part, Pheretima 3-9 part, Hirudo 2-4 part, Fructus Citri Sarcodactylis 3-9 part, Fructus Gardeniae 3-9 part, Radix Scutellariae 3-9 part, Cortex Eucommiae 6-12 part, Herba Leonuri 9-15 part, Herba Taxilli 6-12 part, Caulis Polygoni Multiflori 6-12 part, Poria 9-15 part, Radix Cyathulae 6-12 part, Radix Glycyrrhizae 6-12 part.
Preferably, the Chinese medicine of above-mentioned treatment refractory acne, be made up of the raw material of Chinese medicine medicine of following weight:
Radix Bupleuri 5-7 part, Ramulus Uncariae Cum Uncis 8-10 part, Flos Chrysanthemi 8-10 part, Radix Paeoniae Alba 10-14 part, Rhizoma Cyperi 10-14 part, Pericarpium Citri Reticulatae Viride 8-10 part, Concha Ostreae 10-14 part, Os Draconis 10-14 part, Rhizoma Gastrodiae 5-7 part, Periostracum Cicadae 10-14 part, Herba Menthae 10-14 part, Fructus Forsythiae 10-14 part, Cornu Saigae Tataricae 2.5-3.5 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Chuanxiong 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Radix Paeoniae Rubra 10-14 part, Cortex Moutan 10-14 part, Pheretima 5-7 part, Hirudo 2.5-3.5 part, Fructus Citri Sarcodactylis 5-7 part, Fructus Gardeniae 5-7 part, Radix Scutellariae 5-7 part, Cortex Eucommiae 8-10 part, Herba Leonuri 10-14 part, Herba Taxilli 8-10 part, Caulis Polygoni Multiflori 8-10 part, Poria 10-14 part, Radix Cyathulae 8-10 part, Radix Glycyrrhizae 8-10 part.
Preferred, the Chinese medicine of above-mentioned treatment refractory acne, be made up of the raw material of Chinese medicine medicine of following weight:
Radix Bupleuri 6 parts, Ramulus Uncariae Cum Uncis 9 parts, Flos Chrysanthemi 9 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Cyperi 12 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Concha Ostreae 12 parts, Os Draconis 12 parts, 6 parts, Rhizoma Gastrodiae, Periostracum Cicadae 12 parts, Herba Menthae 12 parts, Fructus Forsythiae 12 parts, Cornu Saigae Tataricae 3 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Chuanxiong 12 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Paeoniae Rubra 12 parts, Cortex Moutan 12 parts, Pheretima 6 parts, Hirudo 3 parts, Fructus Citri Sarcodactylis 6 parts, Fructus Gardeniae 6 parts, Radix Scutellariae 6 parts, the Cortex Eucommiae 9 parts, Herba Leonuri 12 parts, Herba Taxilli 9 parts, Caulis Polygoni Multiflori 9 parts, 12 parts, Poria, Radix Cyathulae 9 parts, 9 parts, Radix Glycyrrhizae.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The Chinese medicine of above-mentioned treatment refractory acne, the dosage form of this Chinese medicine is oral formulations.
The Chinese medicine of above-mentioned treatment refractory acne, the dosage form of this Chinese medicine is granule, tablet, capsule.
The Chinese medicinal preparation method of above-mentioned treatment refractory acne, comprises the steps:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 7-9 times amount for the first time, decoct 1-2 hour, second time adds the water of medical material weight 5-7 times amount, decoct 0.5-1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule, to obtain final product.
In the Chinese medicinal preparation method of above-mentioned treatment refractory acne, in described step (b), amount of water is medical material weight 8 times amount for the first time, decocts 1.5 hours, and second time amount of water is medical material weight 6 times amount, decocts 1 hour.
The Chinese medicinal preparation method of above-mentioned treatment refractory acne, detailed step is:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 8 times amount for the first time, decoct 1.5 hours, second time adds the water of medical material weight 6 times amount, decoct 1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B medical material clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule, to obtain final product.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 10g, every gram, containing crude drug in whole 2.4-3.0g, takes three every day, each 1 bag.
Chinese medicine of the present invention, has depressed liver-energy dispersing and QI regulating, effect of heat clearing and blood circulation promoting, and for obstinate refractory acne, disease sees acne recurrent exerbation, does not unbrokenly heal.
Acne recurrent exerbation, does not unbrokenly heal, and generally, the liver detoxification function of patient is poor, toxin metabolism is not turned round and is walked other excretion pathway, so there is acne recurrent exerbation, in this case, a lot of patient with headache feeling of fullness in the head, the symptoms such as one's ears rang and spots danced before one's eyes, little sleep disturbed by dreams.
In the Chinese medicine for the treatment of refractory acne of the present invention, Radix Bupleuri, Ramulus Uncariae Cum Uncis, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Rhizoma Gastrodiae, Concha Ostreae, Os Draconis depressed liver-energy dispersing and QI regulating, suppressing the hyperactive liver to relieve the wind syndrome; Flos Chrysanthemi, Periostracum Cicadae, Herba Menthae, Fructus Forsythiae, the loose heresy of Cornu Saigae Tataricae cleaning heat and expelling wind, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Cortex Moutan, Pheretima, Hirudo, Herba Leonuri are enriched blood Activating blood system heat, Fructus Gardeniae, Radix Scutellariae clearing heat in QI system, the Cortex Eucommiae, Herba Taxilli, Caulis Polygoni Multiflori, Poria, Radix Cyathulae liver and kidney tonifying, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines share, altogether long memorial liver and qi, effect of heat clearing and blood circulation promoting.Doctor trained in Western medicine is thought, this medicine can strengthen the function of detoxification of liver, promotes the metabolism of toxin, thus refractory acne is thoroughly cured do not recur.
The invention has the advantages that:
(1) the invention provides the Chinese medicine that a kind for the treatment of refractory acne newly goes down, meet clinical needs.
(2) Chinese drug preparation that goes down for the treatment of refractory acne is become granule by the present invention, has both maintained decoction and has absorbed fast, effective feature rapidly, overcomes again before decoction is taken and to decoct temporarily, is long placed in easily mouldly to lose rotten shortcoming, and can cover the bitterness of Chinese medicine.Chinese medicine granules Chinese crude drug of the present invention all through refining extraction, volume-diminished, transporting, carrying, taking convenience.
(3) clinical test results shows, compared with matched group, the Chinese medicine for acne of the present invention, 3 the course for the treatment of obvious effective rate up to 60.29%, and Pifubing Xuedu Pill matched group cure rate only has 23.52%, both have significant difference (p < 0.01); 3 the course for the treatment of total effective rate up to 97.06%, and Pifubing Xuedu Pill matched group effective percentage only has both 58.52% and has significant difference (p < 0.01).And this product not easily recurs after curing, healing group is all followed up a case by regular visits to and is had no recurrence in three months.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Prescription: Radix Bupleuri 6g, Ramulus Uncariae Cum Uncis 9g, Flos Chrysanthemi 9g, Radix Paeoniae Alba 12g, Rhizoma Cyperi 12g, Pericarpium Citri Reticulatae Viride 9g, Concha Ostreae 12g, Os Draconis 12g, Rhizoma Gastrodiae 6g, Periostracum Cicadae 12g, Herba Menthae 12g, Fructus Forsythiae 12g, Cornu Saigae Tataricae 3g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Radix Salviae Miltiorrhizae 12g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Pheretima 6g, Hirudo 3g, Fructus Citri Sarcodactylis 6g, Fructus Gardeniae 6g, Radix Scutellariae 6g, Cortex Eucommiae 9g, Herba Leonuri 12g, Herba Taxilli 9g, Caulis Polygoni Multiflori 9g, Poria 12g, Radix Cyathulae 9g, Radix Glycyrrhizae 9g.Prepare 100g altogether, every packed 10g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 8 times amount for the first time, decoct 1.5 hours, second time adds the water of medical material weight 6 times amount, decoct 1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B medical material clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule, to obtain final product.
Usage and dosage: each 1 bag, every day 2 times.
Embodiment 2
Prescription: Radix Bupleuri 5g, Ramulus Uncariae Cum Uncis 10g, Flos Chrysanthemi 8g, Radix Paeoniae Alba 14g, Rhizoma Cyperi 10g, Pericarpium Citri Reticulatae Viride 10g, Concha Ostreae 10g, Os Draconis 14g, Rhizoma Gastrodiae 5g, Periostracum Cicadae 14g, Herba Menthae 10g, Fructus Forsythiae 14g, Cornu Saigae Tataricae 2.5g, Radix Angelicae Sinensis 14g, Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 14g, Radix Paeoniae Rubra 10g, Cortex Moutan 14g, Pheretima 5g, Hirudo 3.5g, Fructus Citri Sarcodactylis 5g, Fructus Gardeniae 7g, Radix Scutellariae 5g, Cortex Eucommiae 10g, Herba Leonuri 10g, Herba Taxilli 10g, Caulis Polygoni Multiflori 8g, Poria 14g, Radix Cyathulae 8g, Radix Glycyrrhizae 10g.Prepare 100g altogether, every packed 10g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 7 times amount for the first time, decoct 1 hour, second time adds the water of medical material weight 5 times amount, decoct 0.5 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule, to obtain final product.
Usage and dosage: each 1 bag, every day 2 times.
Embodiment 3
Prescription
Prescription: Radix Bupleuri 7g, Ramulus Uncariae Cum Uncis 8g, Flos Chrysanthemi 10g, Radix Paeoniae Alba 10g, Rhizoma Cyperi 14g, Pericarpium Citri Reticulatae Viride 8g, Concha Ostreae 14g, Os Draconis 10g, Rhizoma Gastrodiae 7g, Periostracum Cicadae 10g, Herba Menthae 14g, Fructus Forsythiae 10g, Cornu Saigae Tataricae 3.5g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 14g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Rubra 14g, Cortex Moutan 10g, Pheretima 7g, Hirudo 2.5g, Fructus Citri Sarcodactylis 7g, Fructus Gardeniae 5g, Radix Scutellariae 7g, Cortex Eucommiae 8g, Herba Leonuri 14g, Herba Taxilli 8g, Caulis Polygoni Multiflori 10g, Poria 10g, Radix Cyathulae 10g, Radix Glycyrrhizae 8g.
Prepare 100g altogether, every packed 10g.
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 7-9 times amount for the first time, decoct 1-2 hour, second time adds the water of medical material weight 5-7 times amount, decoct 0.5-1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule, to obtain final product.
Usage and dosage: each 1 bag, every day 2 times.
Embodiment 4
Prescription: Radix Bupleuri 3g, Ramulus Uncariae Cum Uncis 12, Flos Chrysanthemi 6g, Radix Paeoniae Alba 15g, Rhizoma Cyperi 9g, Pericarpium Citri Reticulatae Viride 12g, Concha Ostreae 9g, Os Draconis 15g, Rhizoma Gastrodiae 3g, Periostracum Cicadae 15g, Herba Menthae 9g, Fructus Forsythiae 15g, Cornu Saigae Tataricae 2g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 9g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 9g, Cortex Moutan 15g, Pheretima 3g, Hirudo 4g, Fructus Citri Sarcodactylis 3g, Fructus Gardeniae 9g, Radix Scutellariae 3g, Cortex Eucommiae 12g, Herba Leonuri 9g, Herba Taxilli 12g, Caulis Polygoni Multiflori 6g, Poria 15g, Radix Cyathulae 6g, Radix Glycyrrhizae 12g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 8 times amount for the first time, decoct 1.5 hours, second time adds the water of medical material weight 6 times amount, decoct 1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B medical material clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add magnesium stearate and starch, mixing, make wetting agent with 75% ethanol to granulate, dry, granulate, incapsulate and make capsule, obtain common preparation 100.
Usage and dosage: each 10, every day 2 times.
Embodiment 5
Prescription: Radix Bupleuri 9g, Ramulus Uncariae Cum Uncis 6g, Flos Chrysanthemi 6g, Radix Paeoniae Alba 15g, Rhizoma Cyperi 9g, Pericarpium Citri Reticulatae Viride 12 parts of g, Concha Ostreae 9g, Os Draconis 15g, Rhizoma Gastrodiae 3g, Periostracum Cicadae 15g, Herba Menthae 9g, Fructus Forsythiae 15g, Cornu Saigae Tataricae 2g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 9g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 9g, Cortex Moutan 15g, Pheretima 3g, Hirudo 4g, Fructus Citri Sarcodactylis 3g, Fructus Gardeniae 9g, Radix Scutellariae 3g, the Cortex Eucommiae 12 parts of g, Herba Leonuri 9g, Herba Taxilli 12g, Caulis Polygoni Multiflori 6g, Poria 9g, Radix Cyathulae 12g, Radix Glycyrrhizae 6g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 8 times amount for the first time, decoct 1.5 hours, second time adds the water of medical material weight 6 times amount, decoct 1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
B medical material clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add starch and magnesium stearate, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, tabletting, to obtain final product.Prepare 100 altogether.
Usage and dosage: each 10, every day 2 times.
Carried out clinical pharrnacokinetics test to the preparation of embodiments of the invention l, result is as follows:
1.1 physical data
170 routine patients are my Out-patient Department patient, man 78 example, female 92 example, 13 ~ 45 years old age, the course of disease 1 year ~ 11 years.Random point treatment group and matched group two groups.Wherein treatment group 136 example, matched group 34 example.Diseased region: facial area is common, is also found in breast cervical region, and color is red, the visible pus point of atop part, and acne count is 15-30 at most, at least 6-8.Minority case can be felt and itching and pain.
1.2 Therapeutic Method
Treatment group takes the Chinese medicinal granule of Acne treatment prepared by the embodiment of the present invention 1, each 1 bag, every day 2 times, 7 days 1 courses for the treatment of.Observed result after 3 courses for the treatment of.
Matched group: take Pifubing Xuedu Pill, each 20, every day 2 times, 7 days 1 courses for the treatment of.Observed result after 3 courses for the treatment of.
1.3 observation of curative effect
Therapeutic outcome criterion of therapeutical effect: according to " Chinese medical disease Standardization of diagnosis and curative effect " acne efficacy evaluation.Skin lesion is disappeared, and subjective symptoms disappears, and follows up a case by regular visits to and within 3 months, does not recur for curing.Transfer well skin lesion to and disappear more than 30%, subjective symptoms obviously alleviates.More for skin lesion and symptom is all unchanged or disappear less than 30% (it is invalid to comprise).Therapeutic outcome sees attached list.
Table 1 liang group Comparison of therapeutic
| Group | Number of cases | Cure | Take a turn for the better | Do not heal | Obvious effective rate (%) | Total effective rate (%) |
| Treatment group | 136 | 82 | 50 | 4 | 60.29* | 97.06* |
| Matched group | 34 | 8 | 12 | 14 | 23.53 | 58.82 |
Note: two groups are compared, and P<0.01, difference has statistical significance
Compared with matched group, the Chinese medicine for the treatment of refractory acne of the present invention, 3 the course for the treatment of obvious effective rate up to 60.29%, and Pifubing Xuedu Pill matched group cure rate only has 23.52%, and both have significant difference (p < 0.01); 3 the course for the treatment of total effective rate up to 97.06%, and Pifubing Xuedu Pill matched group effective percentage only has both 58.52% and has significant difference (p < 0.01).
Claims (6)
1. treat a Chinese medicine for refractory acne, be made up of the raw material of Chinese medicine medicine of following weight:
Radix Bupleuri 3-9 part, Ramulus Uncariae Cum Uncis 6-12 part, Flos Chrysanthemi 6-12 part, Radix Paeoniae Alba 9-15 part, Rhizoma Cyperi 9-15 part, Pericarpium Citri Reticulatae Viride 6-12 part, Concha Ostreae 9-15 part, Os Draconis 9-15 part, Rhizoma Gastrodiae 3-9 part, Periostracum Cicadae 9-15 part, Herba Menthae 9-15 part, Fructus Forsythiae 9-15 part, Cornu Saigae Tataricae 2-4 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Paeoniae Rubra 9-15 part, Cortex Moutan 9-15 part, Pheretima 3-9 part, Hirudo 2-4 part, Fructus Citri Sarcodactylis 3-9 part, Fructus Gardeniae 3-9 part, Radix Scutellariae 3-9 part, Cortex Eucommiae 6-12 part, Herba Leonuri 9-15 part, Herba Taxilli 6-12 part, Caulis Polygoni Multiflori 6-12 part, Poria 9-15 part, Radix Cyathulae 6-12 part, Radix Glycyrrhizae 6-12 part.
2. the Chinese medicine for the treatment of refractory acne according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight:
Radix Bupleuri 5-7 part, Ramulus Uncariae Cum Uncis 8-10 part, Flos Chrysanthemi 8-10 part, Radix Paeoniae Alba 10-14 part, Rhizoma Cyperi 10-14 part, Pericarpium Citri Reticulatae Viride 8-10 part, Concha Ostreae 10-14 part, Os Draconis 10-14 part, Rhizoma Gastrodiae 5-7 part, Periostracum Cicadae 10-14 part, Herba Menthae 10-14 part, Fructus Forsythiae 10-14 part, Cornu Saigae Tataricae 2.5-3.5 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Chuanxiong 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Radix Paeoniae Rubra 10-14 part, Cortex Moutan 10-14 part, Pheretima 5-7 part, Hirudo 2.5-3.5 part, Fructus Citri Sarcodactylis 5-7 part, Fructus Gardeniae 5-7 part, Radix Scutellariae 5-7 part, Cortex Eucommiae 8-10 part, Herba Leonuri 10-14 part, Herba Taxilli 8-10 part, Caulis Polygoni Multiflori 8-10 part, Poria 10-14 part, Radix Cyathulae 8-10 part, Radix Glycyrrhizae 8-10 part.
3. the Chinese medicine for the treatment of refractory acne according to claim 2, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight:
Radix Bupleuri 6 parts, Ramulus Uncariae Cum Uncis 9 parts, Flos Chrysanthemi 9 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Cyperi 12 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Concha Ostreae 12 parts, Os Draconis 12 parts, 6 parts, Rhizoma Gastrodiae, Periostracum Cicadae 12 parts, Herba Menthae 12 parts, Fructus Forsythiae 12 parts, Cornu Saigae Tataricae 3 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Chuanxiong 12 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Paeoniae Rubra 12 parts, Cortex Moutan 12 parts, Pheretima 6 parts, Hirudo 3 parts, Fructus Citri Sarcodactylis 6 parts, Fructus Gardeniae 6 parts, Radix Scutellariae 6 parts, the Cortex Eucommiae 9 parts, Herba Leonuri 12 parts, Herba Taxilli 9 parts, Caulis Polygoni Multiflori 9 parts, 12 parts, Poria, Radix Cyathulae 9 parts, 9 parts, Radix Glycyrrhizae.
4. the Chinese medicine of the treatment refractory acne according to claim 1 or 2 or 3, is characterized in that, the dosage form of this Chinese medicine is oral formulations.
5. the Chinese medicinal preparation method of claim 1 or the treatment refractory acne described in 2 or 3, comprises the steps:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is for subsequent use;
B () all the other medical materials add soak by water 2 times, add the water of medical material weight 7-9 times amount for the first time, decoct 1-2 hour, second time adds the water of medical material weight 5-7 times amount, decoct 0.5-1 hour, merge the fried liquid of twice, filter, filtrate reduce pressure at 60 DEG C dense to relative density be the clear paste of 1.09 ~ 1.14, adding ethanol makes alcohol content be 75%, leave standstill 12 hours, filter, filtrate reduce pressure at 60 DEG C dense to relative density be 1.24 ~ 1.28 medical material clear paste;
C clear paste that step (b) is prepared by () and the obtained Pheretima of step (a), Hirudo, Cornu Saigae Tataricae fine powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule, to obtain final product.
6. the Chinese medicinal preparation method for the treatment of refractory acne according to claim 5, is characterized in that, in described step (b), amount of water is medical material weight 8 times amount for the first time, decocts 1.5 hours, and second time amount of water is medical material weight 6 times amount, decocts 1 hour.
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| CN107485700A (en) * | 2016-08-31 | 2017-12-19 | 单晓春 | Qing Gan Capsule and its preparation method and application |
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| CN101032593A (en) * | 2007-04-16 | 2007-09-12 | 北京艺信堂医药研究所 | Acne-treating Chinese medicine preparation |
| CN101513479A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicinal capsule with efficacies in regulating menstruation and removing spots, and preparation method thereof |
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