CN103638335A - Traditional Chinese medicine for treating refractory acne and preparation method thereof - Google Patents
Traditional Chinese medicine for treating refractory acne and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of medical technology, and particularly relates to a traditional Chinese medicine for treating refractory acne and a preparation method thereof. The traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials: radix bupleuri, uncaria rhynchophylla, flos chrysanthemi, radix paeoniae alba, rhizoma cyperi, green tangerine peel, oyster, fossil fragments, rhizoma gastrodiae, cicada slough, mint, fructus forsythiae, cornu saigae tataricae, Chinese angelica, rhizoma ligustici chuanxiong, radix salviae miltiorrhizae, radix paeoniae rubra, cortex moutan, earthworm, leech, fingered citron, fructus gardeniae, radix scutellariae, cortex eucommiae, herba leonuri, herba taxilli, tuber fleeceflower stem, poria cocos, radix cyathulae and radix glycyrrhizae. The traditional Chinese medicine provided by the invention has the functions of soothing the liver and regulating qi and clearing heat and activating blood, and is applied to the severe and lingering refractory acne with symptoms of repeated attacking and lingering healing.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine for the treatment of intractable acne and preparation method thereof.
Background technology
Acne is again acne, is to be grown in people's face and a kind of inflammatory dermatosis of chest and back.Mostly this sick is to cause due to patient body internal hormone diacrisis if being, its skin lesion can show as pimple, pustule, scleroma and cyst, and patient mostly is in hebetic teenager.Generally, most patients with acne are after adolescence, and its state of an illness can be fully recovered voluntarily.But also some patients with acne is after adolescence, and its state of an illness is outbreak repeatedly still, clinically this disease is called to intractable acne.The cause of disease of intractable acne also imperfectly understands at present, this sick main and patient occur serious endocrine disturbance, repeated infection propionibacterium acnes, smegma vigorous, often eat food pungent, excitatory or be associated with the factors such as other inflammatory dermatosiss relevant.Intractable acne not only can affect patient's appearance, at it, leaves ugly cicatrix with it or on the face
The medicine of Acne treatment is numerous at present, but for intractable acne, also lacks good effect, is difficult for the medicine of recurrence after curing.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine for the treatment of intractable acne and preparation method thereof.
The present invention realizes by following technical scheme:
Treat a Chinese medicine for intractable acne, by the raw material of Chinese medicine medicine of following weight portion proportioning, made:
Radix Bupleuri 3-9 part, Ramulus Uncariae Cum Uncis 6-12 part, Flos Chrysanthemi 6-12 part, Radix Paeoniae Alba 9-15 part, Rhizoma Cyperi 9-15 part, Pericarpium Citri Reticulatae Viride 6-12 part, Concha Ostreae 9-15 part, Os Draconis 9-15 part, Rhizoma Gastrodiae 3-9 part, Periostracum Cicadae 9-15 part, Herba Menthae 9-15 part, Fructus Forsythiae 9-15 part, Cornu Saigae Tataricae 2-4 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Paeoniae Rubra 9-15 part, Cortex Moutan 9-15 part, Pheretima 3-9 part, Hirudo 2-4 part, Fructus Citri Sarcodactylis 3-9 part, Fructus Gardeniae 3-9 part, Radix Scutellariae 3-9 part, Cortex Eucommiae 6-12 part, Herba Leonuri 9-15 part, Herba Taxilli 6-12 part, Caulis Polygoni Multiflori 6-12 part, Poria 9-15 part, Radix Cyathulae 6-12 part, Radix Glycyrrhizae 6-12 part.
Preferably, the Chinese medicine of above-mentioned treatment intractable acne, by the raw material of Chinese medicine medicine of following weight portion proportioning, made:
Radix Bupleuri 5-7 part, Ramulus Uncariae Cum Uncis 8-10 part, Flos Chrysanthemi 8-10 part, Radix Paeoniae Alba 10-14 part, Rhizoma Cyperi 10-14 part, Pericarpium Citri Reticulatae Viride 8-10 part, Concha Ostreae 10-14 part, Os Draconis 10-14 part, Rhizoma Gastrodiae 5-7 part, Periostracum Cicadae 10-14 part, Herba Menthae 10-14 part, Fructus Forsythiae 10-14 part, Cornu Saigae Tataricae 2.5-3.5 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Chuanxiong 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Radix Paeoniae Rubra 10-14 part, Cortex Moutan 10-14 part, Pheretima 5-7 part, Hirudo 2.5-3.5 part, Fructus Citri Sarcodactylis 5-7 part, Fructus Gardeniae 5-7 part, Radix Scutellariae 5-7 part, Cortex Eucommiae 8-10 part, Herba Leonuri 10-14 part, Herba Taxilli 8-10 part, Caulis Polygoni Multiflori 8-10 part, Poria 10-14 part, Radix Cyathulae 8-10 part, Radix Glycyrrhizae 8-10 part.
Preferred, the Chinese medicine of above-mentioned treatment intractable acne, by the raw material of Chinese medicine medicine of following weight portion proportioning, made:
6 parts of Radix Bupleuri, 9 parts of Ramulus Uncariae Cum Uncis, 9 parts of Flos Chrysanthemis, 12 parts of the Radix Paeoniae Albas, 12 parts of Rhizoma Cyperis, 9 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Concha Ostreaes, 12 parts of Os Draconis, 6 parts, Rhizoma Gastrodiae, 12 parts of Periostracum Cicadaes, 12 parts of Herba Menthaes, 12 parts of Fructus Forsythiaes, 3 parts of Cornu Saigae Tataricae, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Paeoniae Rubra, 12 parts of Cortex Moutans, 6 parts of Pheretimas, 3 parts of Hirudos, 6 parts of Fructus Citri Sarcodactylis, 6 parts of Fructus Gardeniaes, 6 parts of Radix Scutellariaes, 9 parts of the Cortexs Eucommiae, 12 parts of Herba Leonuris, 9 parts of Herba Taxillis, 9 parts of Caulis Polygoni Multiflori, 12 parts, Poria, 9 parts of Radix Cyathulaes, 9 parts, Radix Glycyrrhizae.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount can corresponding adjustment forming, increases or reduces being no more than 100%, and drug effect is substantially constant.
The Chinese medicine of above-mentioned treatment intractable acne, the dosage form of this Chinese medicine is oral formulations.
The Chinese medicine of above-mentioned treatment intractable acne, the dosage form of this Chinese medicine is granule, tablet, capsule.
The Chinese medicinal preparation method of above-mentioned treatment intractable acne, comprises the steps:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, add for the first time the water that medical material weight 7-9 doubly measures, decoct 1-2 hour, add for the second time the water that medical material weight 5-7 doubly measures, decoct 0.5-1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
In the Chinese medicinal preparation method of above-mentioned treatment intractable acne, in described step (b), amount of water is 8 times of amounts of medical material weight for the first time, decocts 1.5 hours, and amount of water is 6 times of amounts of medical material weight for the second time, decocts 1 hour.
The Chinese medicinal preparation method of above-mentioned treatment intractable acne, detailed step is:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, the water that adds for the first time 8 times of amounts of medical material weight, decocts 1.5 hours, adds for the second time the water of 6 times of amounts of medical material weight, decoct 1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the medical material clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 10g, every gram contains crude drug in whole 2.4-3.0g, takes each 1 bag every day three times.
Chinese medicine of the present invention, has depressed liver-energy dispersing and QI regulating, the effect of heat clearing and blood circulation promoting, and for obstinate intractable acne, disease sees that acne shows effect repeatedly, does not unbrokenly heal.
Acne is shown effect repeatedly, does not unbrokenly heal, and generally, patient's liver detoxification function is poor, toxin metabolism is not turned round and is walked other excretion pathway, so occurred that acne shows effect repeatedly, and in this case, the symptoms such as a lot of patients are with headache feeling of fullness in the head, and one's ears rang and spots danced before one's eyes, little sleep disturbed by dreams.
In the Chinese medicine for the treatment of intractable acne of the present invention, Radix Bupleuri, Ramulus Uncariae Cum Uncis, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Rhizoma Gastrodiae, Concha Ostreae, Os Draconis depressed liver-energy dispersing and QI regulating, suppressing the hyperactive liver to relieve the wind syndrome; Flos Chrysanthemi, Periostracum Cicadae, Herba Menthae, Fructus Forsythiae, the loose heresy of Cornu Saigae Tataricae cleaning heat and expelling wind, enrich blood Activating blood system heat of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Cortex Moutan, Pheretima, Hirudo, Herba Leonuri, Fructus Gardeniae, Radix Scutellariae clearing heat in QI system, the Cortex Eucommiae, Herba Taxilli, Caulis Polygoni Multiflori, Poria, Radix Cyathulae liver and kidney tonifying, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines share, and are total to long memorial liver and qi, the effect of heat clearing and blood circulation promoting.Doctor trained in Western medicine thinks, this medicine can strengthen the function of detoxification of liver, promotes the metabolism of toxin, thereby the thorough healing of intractable acne is not recurred.
The invention has the advantages that:
(1) the invention provides the Chinese medicine that a kind of new treatment intractable acne goes down, met clinical needs.
(2) Chinese drug preparation that treatment intractable acne is gone down in the present invention becomes granule, has both kept decoction to absorb fast, effective feature rapidly, has overcome again decoction and has taken front interim decoction, is long placed in easily mouldly to lose rotten shortcoming, and can covers the bitterness of Chinese medicine.Chinese medicine granules Chinese crude drug of the present invention all extracts through refining, and volume-diminished is transported, carried, taking convenience.
(3) clinical test results shows, compare with matched group, the Chinese medicine for acne of the present invention, 3 the course for the treatment of obvious effective rate up to 60.29%, and Pifubing Xuedu Pill matched group cure rate only has 23.52%, both have significant difference (p < 0.01); 3 the course for the treatment of total effective rate up to 97.06%, and Pifubing Xuedu Pill matched group effective percentage only have 58.52% both there is significant difference (p < 0.01).And this product is difficult for recurrence after curing, and healing group is all followed up a case by regular visits to and within three months, had no recurrence.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Prescription: Radix Bupleuri 6g, Ramulus Uncariae Cum Uncis 9g, Flos Chrysanthemi 9g, Radix Paeoniae Alba 12g, Rhizoma Cyperi 12g, Pericarpium Citri Reticulatae Viride 9g, Concha Ostreae 12g, Os Draconis 12g, Rhizoma Gastrodiae 6g, Periostracum Cicadae 12g, Herba Menthae 12g, Fructus Forsythiae 12g, Cornu Saigae Tataricae 3g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Radix Salviae Miltiorrhizae 12g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Pheretima 6g, Hirudo 3g, Fructus Citri Sarcodactylis 6g, Fructus Gardeniae 6g, Radix Scutellariae 6g, Cortex Eucommiae 9g, Herba Leonuri 12g, Herba Taxilli 9g, Caulis Polygoni Multiflori 9g, Poria 12g, Radix Cyathulae 9g, Radix Glycyrrhizae 9g.Prepare altogether 100g, every packed 10g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, the water that adds for the first time 8 times of amounts of medical material weight, decocts 1.5 hours, adds for the second time the water of 6 times of amounts of medical material weight, decoct 1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the medical material clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
Usage and dosage: each 1 bag, every day 2 times.
Embodiment 2
Prescription: Radix Bupleuri 5g, Ramulus Uncariae Cum Uncis 10g, Flos Chrysanthemi 8g, Radix Paeoniae Alba 14g, Rhizoma Cyperi 10g, Pericarpium Citri Reticulatae Viride 10g, Concha Ostreae 10g, Os Draconis 14g, Rhizoma Gastrodiae 5g, Periostracum Cicadae 14g, Herba Menthae 10g, Fructus Forsythiae 14g, Cornu Saigae Tataricae 2.5g, Radix Angelicae Sinensis 14g, Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 14g, Radix Paeoniae Rubra 10g, Cortex Moutan 14g, Pheretima 5g, Hirudo 3.5g, Fructus Citri Sarcodactylis 5g, Fructus Gardeniae 7g, Radix Scutellariae 5g, Cortex Eucommiae 10g, Herba Leonuri 10g, Herba Taxilli 10g, Caulis Polygoni Multiflori 8g, Poria 14g, Radix Cyathulae 8g, Radix Glycyrrhizae 10g.Prepare altogether 100g, every packed 10g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, the water that adds for the first time 7 times of amounts of medical material weight, decocts 1 hour, adds for the second time the water of 5 times of amounts of medical material weight, decoct 0.5 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
Usage and dosage: each 1 bag, every day 2 times.
Embodiment 3
Prescription
Prescription: Radix Bupleuri 7g, Ramulus Uncariae Cum Uncis 8g, Flos Chrysanthemi 10g, Radix Paeoniae Alba 10g, Rhizoma Cyperi 14g, Pericarpium Citri Reticulatae Viride 8g, Concha Ostreae 14g, Os Draconis 10g, Rhizoma Gastrodiae 7g, Periostracum Cicadae 10g, Herba Menthae 14g, Fructus Forsythiae 10g, Cornu Saigae Tataricae 3.5g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 14g, Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Rubra 14g, Cortex Moutan 10g, Pheretima 7g, Hirudo 2.5g, Fructus Citri Sarcodactylis 7g, Fructus Gardeniae 5g, Radix Scutellariae 7g, Cortex Eucommiae 8g, Herba Leonuri 14g, Herba Taxilli 8g, Caulis Polygoni Multiflori 10g, Poria 10g, Radix Cyathulae 10g, Radix Glycyrrhizae 8g.
Prepare altogether 100g, every packed 10g.
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, add for the first time the water that medical material weight 7-9 doubly measures, decoct 1-2 hour, add for the second time the water that medical material weight 5-7 doubly measures, decoct 0.5-1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
Usage and dosage: each 1 bag, every day 2 times.
Embodiment 4
Prescription: Radix Bupleuri 3g, Ramulus Uncariae Cum Uncis 12, Flos Chrysanthemi 6g, Radix Paeoniae Alba 15g, Rhizoma Cyperi 9g, Pericarpium Citri Reticulatae Viride 12g, Concha Ostreae 9g, Os Draconis 15g, Rhizoma Gastrodiae 3g, Periostracum Cicadae 15g, Herba Menthae 9g, Fructus Forsythiae 15g, Cornu Saigae Tataricae 2g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 9g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 9g, Cortex Moutan 15g, Pheretima 3g, Hirudo 4g, Fructus Citri Sarcodactylis 3g, Fructus Gardeniae 9g, Radix Scutellariae 3g, Cortex Eucommiae 12g, Herba Leonuri 9g, Herba Taxilli 12g, Caulis Polygoni Multiflori 6g, Poria 15g, Radix Cyathulae 6g, Radix Glycyrrhizae 12g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, the water that adds for the first time 8 times of amounts of medical material weight, decocts 1.5 hours, adds for the second time the water of 6 times of amounts of medical material weight, decoct 1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the medical material clear paste of being prepared by step (b) and step (a) make, add magnesium stearate and starch, mixes, with 75% ethanol, make wetting agent and granulate, dry, granulate, incapsulate and make capsule, obtain 100 of common preparations.
Usage and dosage: each 10, every day 2 times.
Embodiment 5
Prescription: Radix Bupleuri 9g, Ramulus Uncariae Cum Uncis 6g, Flos Chrysanthemi 6g, Radix Paeoniae Alba 15g, Rhizoma Cyperi 9g, 12 parts of g of Pericarpium Citri Reticulatae Viride, Concha Ostreae 9g, Os Draconis 15g, Rhizoma Gastrodiae 3g, Periostracum Cicadae 15g, Herba Menthae 9g, Fructus Forsythiae 15g, Cornu Saigae Tataricae 2g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 9g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 9g, Cortex Moutan 15g, Pheretima 3g, Hirudo 4g, Fructus Citri Sarcodactylis 3g, Fructus Gardeniae 9g, Radix Scutellariae 3g, 12 parts of g of the Cortex Eucommiae, Herba Leonuri 9g, Herba Taxilli 12g, Caulis Polygoni Multiflori 6g, Poria 9g, Radix Cyathulae 12g, Radix Glycyrrhizae 6g.
Preparation method:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, the water that adds for the first time 8 times of amounts of medical material weight, decocts 1.5 hours, adds for the second time the water of 6 times of amounts of medical material weight, decoct 1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the medical material clear paste of being prepared by step (b) and step (a) make, add starch and magnesium stearate, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and tabletting, obtains.Prepare altogether 100.
Usage and dosage: each 10, every day 2 times.
The preparation of embodiments of the invention l has been carried out to clinical pharmacodynamics test, and result is as follows:
1.1 physical data
170 routine patients are my Out-patient Department patient, male 78 examples, female's 92 examples, 13 ~ 45 years old age, the course of disease 1 year ~ 11 years.Two groups of random minute treatment group and matched groups.Treatment group 136 examples wherein, matched group 34 examples.Diseased region: facial area is common, is also found in breast cervical region, and color is red, the visible pus point in part top, and acne quantity is 15-30 at most, at least 6-8.Minority case can be felt and itching and pain.
1.2 Therapeutic Method
Treatment group is taken the Chinese medicinal granule of the Acne treatment of the embodiment of the present invention 1 preparation, each 1 bag, every day 2 times, 7 days 1 courses for the treatment of.Observed result after 3 courses for the treatment of.
Matched group: take Pifubing Xuedu Pill, each 20, every day 2 times, 7 days 1 courses for the treatment of.Observed result after 3 courses for the treatment of.
1.3 observation of curative effect
Therapeutic outcome criterion of therapeutical effect: according to < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > acne efficacy evaluation.Skin lesion is disappeared, and subjective symptoms disappears, and follows up a case by regular visits to and does not recur for curing for 3 months.Transfer well skin lesion to and disappear more than 30%, subjective symptoms obviously alleviates.Be not more all unchanged or less thaies 30% that disappears (it is invalid to comprise) of skin lesion and symptom.Therapeutic outcome sees attached list.
Table 1 liang group Comparison of therapeutic
| Group | Number of cases | Cure | Take a turn for the better | Do not heal | Obvious effective rate (%) | Total effective rate (%) |
| Treatment group | 136 | 82 | 50 | 4 | 60.29* | 97.06* |
| Matched group | 34 | 8 | 12 | 14 | 23.53 | 58.82 |
Note: two groups of comparisons, P<0.01, difference has statistical significance
Compare with matched group, the Chinese medicine for the treatment of intractable acne of the present invention, 3 the course for the treatment of obvious effective rate up to 60.29%, and Pifubing Xuedu Pill matched group cure rate only has 23.52%, both have significant difference (p < 0.01); 3 the course for the treatment of total effective rate up to 97.06%, and Pifubing Xuedu Pill matched group effective percentage only have 58.52% both there is significant difference (p < 0.01).
Claims (8)
1. treat a Chinese medicine for intractable acne, by the raw material of Chinese medicine medicine of following weight portion proportioning, made:
Radix Bupleuri 3-9 part, Ramulus Uncariae Cum Uncis 6-12 part, Flos Chrysanthemi 6-12 part, Radix Paeoniae Alba 9-15 part, Rhizoma Cyperi 9-15 part, Pericarpium Citri Reticulatae Viride 6-12 part, Concha Ostreae 9-15 part, Os Draconis 9-15 part, Rhizoma Gastrodiae 3-9 part, Periostracum Cicadae 9-15 part, Herba Menthae 9-15 part, Fructus Forsythiae 9-15 part, Cornu Saigae Tataricae 2-4 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Paeoniae Rubra 9-15 part, Cortex Moutan 9-15 part, Pheretima 3-9 part, Hirudo 2-4 part, Fructus Citri Sarcodactylis 3-9 part, Fructus Gardeniae 3-9 part, Radix Scutellariae 3-9 part, Cortex Eucommiae 6-12 part, Herba Leonuri 9-15 part, Herba Taxilli 6-12 part, Caulis Polygoni Multiflori 6-12 part, Poria 9-15 part, Radix Cyathulae 6-12 part, Radix Glycyrrhizae 6-12 part.
2. the Chinese medicine for the treatment of intractable acne according to claim 1, is characterized in that, by the raw material of Chinese medicine medicine of following weight portion proportioning, is made:
Radix Bupleuri 5-7 part, Ramulus Uncariae Cum Uncis 8-10 part, Flos Chrysanthemi 8-10 part, Radix Paeoniae Alba 10-14 part, Rhizoma Cyperi 10-14 part, Pericarpium Citri Reticulatae Viride 8-10 part, Concha Ostreae 10-14 part, Os Draconis 10-14 part, Rhizoma Gastrodiae 5-7 part, Periostracum Cicadae 10-14 part, Herba Menthae 10-14 part, Fructus Forsythiae 10-14 part, Cornu Saigae Tataricae 2.5-3.5 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Chuanxiong 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Radix Paeoniae Rubra 10-14 part, Cortex Moutan 10-14 part, Pheretima 5-7 part, Hirudo 2.5-3.5 part, Fructus Citri Sarcodactylis 5-7 part, Fructus Gardeniae 5-7 part, Radix Scutellariae 5-7 part, Cortex Eucommiae 8-10 part, Herba Leonuri 10-14 part, Herba Taxilli 8-10 part, Caulis Polygoni Multiflori 8-10 part, Poria 10-14 part, Radix Cyathulae 8-10 part, Radix Glycyrrhizae 8-10 part.
3. the Chinese medicine for the treatment of intractable acne according to claim 3, is characterized in that, by the raw material of Chinese medicine medicine of following weight portion proportioning, is made:
6 parts of Radix Bupleuri, 9 parts of Ramulus Uncariae Cum Uncis, 9 parts of Flos Chrysanthemis, 12 parts of the Radix Paeoniae Albas, 12 parts of Rhizoma Cyperis, 9 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Concha Ostreaes, 12 parts of Os Draconis, 6 parts, Rhizoma Gastrodiae, 12 parts of Periostracum Cicadaes, 12 parts of Herba Menthaes, 12 parts of Fructus Forsythiaes, 3 parts of Cornu Saigae Tataricae, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Radix Paeoniae Rubra, 12 parts of Cortex Moutans, 6 parts of Pheretimas, 3 parts of Hirudos, 6 parts of Fructus Citri Sarcodactylis, 6 parts of Fructus Gardeniaes, 6 parts of Radix Scutellariaes, 9 parts of the Cortexs Eucommiae, 12 parts of Herba Leonuris, 9 parts of Herba Taxillis, 9 parts of Caulis Polygoni Multiflori, 12 parts, Poria, 9 parts of Radix Cyathulaes, 9 parts, Radix Glycyrrhizae.
4. according to the Chinese medicine of the treatment intractable acne described in claim 1 or 2 or 3, it is characterized in that, the dosage form of this Chinese medicine is oral formulations.
5. the Chinese medicine for the treatment of intractable acne according to claim 4, is characterized in that, the dosage form of this Chinese medicine is granule, tablet, capsule.
6. the Chinese medicinal preparation method of the treatment intractable acne described in claim 1 or 2 or 3, comprises the steps:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, add for the first time the water that medical material weight 7-9 doubly measures, decoct 1-2 hour, add for the second time the water that medical material weight 5-7 doubly measures, decoct 0.5-1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
7. the Chinese medicinal preparation method for the treatment of intractable acne according to claim 6, is characterized in that, in described step (b), amount of water is 8 times of amounts of medical material weight for the first time, decocts 1.5 hours, and amount of water is 6 times of amounts of medical material weight for the second time, decocts 1 hour.
8. the Chinese medicinal preparation method for the treatment of intractable acne according to claim 6, detailed step is:
(a) by Pheretima, Hirudo, that Cornu Saigae Tataricae powder is broken into fine powder is standby;
(b) all the other medical materials add that decocting boils 2 times, the water that adds for the first time 8 times of amounts of medical material weight, decocts 1.5 hours, adds for the second time the water of 6 times of amounts of medical material weight, decoct 1 hour, merge the fried liquid of twice, filter, the filtrate dense clear paste that is 1.09～1.14 to relative density that reduces pressure at 60 ℃, add ethanol make containing alcohol amount be 75%, standing 12 hours, filter the filtrate dense medical material clear paste that is 1.24～1.28 to relative density that reduces pressure at 60 ℃;
(b) Pheretima, Hirudo, Cornu Saigae Tataricae fine powder that the medical material clear paste of being prepared by step (b) and step (a) make, add sucrose, mixes, and makes wetting agent granulate with 75% ethanol, dry, granulate, and granulation agent, obtains.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105616837A (en) * | 2016-01-28 | 2016-06-01 | 蒋丽红 | Traditional Chinese medicine for treating acne and preparation method thereof |
| CN107485700A (en) * | 2016-08-31 | 2017-12-19 | 单晓春 | Qing Gan Capsule and its preparation method and application |
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| CN110742953A (en) * | 2019-10-28 | 2020-02-04 | 高妮娜 | A pharmaceutical composition for treating acne and preparation method thereof |
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|---|---|---|---|---|
| CN101028490A (en) * | 2007-04-16 | 2007-09-05 | 北京艺信堂医药研究所 | Chinese medicine for treating acne |
| CN101032593A (en) * | 2007-04-16 | 2007-09-12 | 北京艺信堂医药研究所 | Acne-treating Chinese medicine preparation |
| CN101513479A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicinal capsule with efficacies in regulating menstruation and removing spots, and preparation method thereof |
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| CN101028490A (en) * | 2007-04-16 | 2007-09-05 | 北京艺信堂医药研究所 | Chinese medicine for treating acne |
| CN101032593A (en) * | 2007-04-16 | 2007-09-12 | 北京艺信堂医药研究所 | Acne-treating Chinese medicine preparation |
| CN101513479A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicinal capsule with efficacies in regulating menstruation and removing spots, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105616837A (en) * | 2016-01-28 | 2016-06-01 | 蒋丽红 | Traditional Chinese medicine for treating acne and preparation method thereof |
| CN107485700A (en) * | 2016-08-31 | 2017-12-19 | 单晓春 | Qing Gan Capsule and its preparation method and application |
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