CN104436048A - Use of traditional Chinese medicine preparation in preparation of medicine for treating qi stagnation and blood stasis type chloasma - Google Patents
Use of traditional Chinese medicine preparation in preparation of medicine for treating qi stagnation and blood stasis type chloasma Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and in particular relates to use of a traditional Chinese medicine preparation in preparation of a medicine for treating qi stagnation and blood stasis type chloasma. The traditional Chinese medicine preparation disclosed by the invention comprises the components including radix bupleuri, salvia miltiorrhiza, ligusticum wallichii, radix rehmanniae, caulis spatholobi, cape jasmine, curcuma aromatica, trigone, peach kernel, curcuma zedoary, fried fructus aurantii and liquorice. The traditional Chinese medicine preparation disclosed by the invention has the effects of soothing liver, regulating qi, promoting blood circulation and removing blood stasis, and is accurate in curative effect and safe and reliable for treating chloasma; and thus, the traditional Chinese medicine preparation disclosed by the invention can be used as the effective method for treating chloasma.
Description
Technical field
The invention belongs to medical art, be specifically related to the purposes of a kind of Chinese medicine preparation in preparation treatment qi stagnation and blood stasis type chloasma medicine.
Background technology
Along with social development, levels of substance improves constantly, the pursuit of people to U.S. is also strengthened gradually, especially women asks kindness to know obviously enhancing, and chloasma is as one of current damage capacitive disease, although skin lesion can not bring the discomfort such as patient pain, pruritus, it has a strong impact on instrument, often bring certain social pressure and mental pressure to patient, this is the problem that Medical circle and beauty treatment circle all pay special attention to.
Chloasma a kind of mainly occurs the filbert or calm dyskinetic dermatosis of brown pigment of limitation with facial area.Be mainly in the places such as forehead, two cheekbones, buccal, nose and mouth week, skin lesion is filbert to dark brown pigmentation spots, often symmetrical, without desquamation, clear border, smooth surface, local is without pain and pruritus, and after Exposure to Sunlight, pigment is deepened, and is generally mainly in female middle-aged and gravidic women.Its syndrome-classification comprises qi stagnation and blood stasis type: yellowish-brown patch appears in face, soreness of the waist and knees, or being irritable and getting angry easily, distending pain in the chest and hypochondrium.Dark tongue quality, white and thin fur, deep-thready pulse.Liver-kidney yin deficiency: macula lutea is brown black, companion's soreness of the waist and knees, indolent and listless unable, thin and weak body.Red tongue, tongue is few, deep-thready pulse.
Current doctor trained in Western medicine is not very good to the treatment of this disease, and side effect is larger.The treatment of the traditional Chinese medical science to this disease have accumulated rich experience, and curative effect is comparatively definite, and side effect is little, this is sick to allow increasing patient select traditional Chinese medical herbal treatment, therefore, strengthens the research and discovery of this interior syndrome doctor Chinese medicine aspect, improvement conditions of patients that can be more definite is better patient service.
Summary of the invention
The invention provides the purposes of a kind of Chinese medicine preparation in preparation treatment qi stagnation and blood stasis type chloasma medicine, this Chinese medicine preparation good effect, toxic and side effects is little, and it is obtained by following raw material: Radix Bupleuri, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Rehmanniae, Caulis Spatholobi, Fructus Gardeniae, Radix Curcumae, Rhizoma Sparganii, Semen Persicae, Rhizoma Curcumae, Fructus Aurantii (parched), Radix Glycyrrhizae.
Chinese medicine preparation of the present invention, described Radix Bupleuri, bitter, be slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Radix Salviae Miltiorrhizae, bitter, be slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Rhizoma Chuanxiong, pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Rehmanniae, another name Radix Rehmanniae is the tuber of scrophulariaceae rehmannia glutinosa plant.Sweet, cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Caulis Spatholobi, sweet, bitter, temperature.Return liver, kidney channel.Enrich blood and invigorate blood circulation, dredging collateral, relaxing muscles and tendons to promote blood circulation.For blood deficiency and yellow complexion, menoxenia, amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Fructus Gardeniae, bitter, cold.GUIXIN, lung, tri-jiao channel.Fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.Root: eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.For infectious hepatitis, traumatic injury, acute toothache.
Radix Curcumae, pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Rhizoma Sparganii, acrid in the mouth is puckery, cool; Liver; Spleen channel.Removing blood stasis circulation of qi promoting; Removing food stagnancy pain relieving.Primary symptom abdominal mass mass in the abdomen; The stagnant amenorrhea of the stasis of blood; Dysmenorrhea; Food stagnation distending pain; Fall the year pain of injury.
Semen Persicae, sweet, bitter, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, dysmenorrhea ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache, dryness of the intestine constipation.
Rhizoma Curcumae, pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Fructus Aurantii (parched), bitter, sour, be slightly cold.Return liver, spleen, large intestine channel.Regulating the flow of QI to ease the stomach, transforming phlegm and dispersing accumulations.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, heavy after dysentery, hemorrhoidal hamorrhage haemorrhoids, proctoptosis, the prolapse of the uterus, rubella pruritus.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention is pure Chinese medicinal preparation, to human body particularly to liver avirulence.Chinese medicine preparation of the present invention follows strengthening vital QI to eliminate pathogenic factors, the Therapeutic Principle for the treatment of both the principal and secondary aspects of a disease, and all medicines share, altogether effect of long memorial liver and qi, blood circulation promoting and blood stasis dispelling.The technical scheme adopted for solving its technical problem is the purposes of a kind of Chinese medicine preparation in preparation treatment qi stagnation and blood stasis type chloasma medicine, and described Chinese medicine preparation is made up of the medicine material of following weight: Radix Bupleuri 7-21 part, Radix Salviae Miltiorrhizae 9-21 part, Rhizoma Chuanxiong 4-16 part, Radix Rehmanniae 9-21 part, Caulis Spatholobi 9-21 part, Fructus Gardeniae 2-13 part, Radix Curcumae 9-21 part, Rhizoma Sparganii 2-10 part, Semen Persicae 4-16 part, Rhizoma Curcumae 2-10 part, Fructus Aurantii (parched) 2-10 part, Radix Glycyrrhizae 2-13 part.
The preferred technical solution of the present invention is, described Chinese medicine preparation of the present invention is obtained by the raw material of following weight portion: Radix Bupleuri 14 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Chuanxiong 10 parts, 15 parts, the Radix Rehmanniae, Caulis Spatholobi 15 parts, Fructus Gardeniae 8 parts, Radix Curcumae 15 parts, Rhizoma Sparganii 6 parts, 10 parts, Semen Persicae, Rhizoma Curcumae 6 parts, Fructus Aurantii (parched) 6 parts, 8 parts, Radix Glycyrrhizae.
Present invention also offers the preparation method of described Chinese medicine preparation, specific as follows: the dry medicine raw material getting ingredients in prescription, removing impurity, cleans, drying, uses cold water soak 30min, boils 10min, filtering medicinal residues extracting juice, medicinal residues repeat above-mentioned technique once, for subsequent use after mixing twice filtrate cooling.Those skilled in the art can add adjuvant conventional formulation technique on this basis can obtain various dosage forms conventional clinically.In order to facilitate patient to use Chinese medicine preparation of the present invention better, Chinese medicine preparation of the present invention conveniently technique can be prepared into oral formulations conventional clinically, as decoction, water preparation, mixture, tablet, capsule, granule or powder etc.It is further preferred that Chinese medicine preparation of the present invention conveniently preparation technology be prepared into decoction.In prepared decoction, every milliliter of medicinal liquid containing crude drug amount 0.1g, 1 dose/day, when being used for the treatment of chloasma, each decoction being taken warmly 1 time after meal sooner or later, each 150mL.
The present invention also asks to protect above-mentioned Chinese medicine preparation in the purposes of preparation treatment chloasma particularly in preparation treatment qi stagnation and blood stasis type chloasma medicine.After by the safety evaluatio of Chinese medicine preparation of the present invention, clinical case is selected to observe in 110 known treated routine qi stagnation and blood stasis type patient with chloasma, the treatment total effective rate for the treatment of group is 97.27%, the treatment total effective rate for the treatment of group is apparently higher than matched group, P<0.05, has statistical significance.Result shows, Chinese medicine preparation of the present invention has extremely significant curative effect to treatment qi stagnation and blood stasis type patient with chloasma.Treatment group follows up a case by regular visits to 1 year, and no case was recurrence, treatments period has no adverse reaction.Reach the object of depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling after thus Chinese medicine preparation prescription of the present invention being described, serve the remarkable result that treatment chloasma particularly treats qi stagnation and blood stasis type chloasma.
Chinese medicine preparation preparation technology of the present invention medicine simple to operation, former is easy to get, with low cost, follow the prescriptions principle of the traditional Chinese medical science, untoward reaction and side effect significantly reduce, safety coefficient is high, through clinical practice checking, its determined curative effect, mild in medicine property and, there is not toxic and side effects and serious adverse reaction, chloasma particularly qi stagnation and blood stasis type chloasma can be treated preferably.Chinese medicine preparation of the present invention is used to treat chloasma determined curative effect, safe and reliable, can be used as the effective ways for the treatment of chloasma.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
embodiment 1, prescription 1
The each raw material of the present invention is taken: Radix Bupleuri 14 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Chuanxiong 10 parts, 15 parts, the Radix Rehmanniae, Caulis Spatholobi 15 parts, Fructus Gardeniae 8 parts, Radix Curcumae 15 parts, Rhizoma Sparganii 6 parts, 10 parts, Semen Persicae, Rhizoma Curcumae 6 parts, Fructus Aurantii (parched) 6 parts, 8 parts, Radix Glycyrrhizae by following weight portion.
embodiment 2, prescription 2
The each raw material of the present invention is taken: Radix Bupleuri 8 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Chuanxiong 5 parts, 10 parts, the Radix Rehmanniae, Caulis Spatholobi 10 parts, Fructus Gardeniae 3 parts, Radix Curcumae 10 parts, Rhizoma Sparganii 3 parts, 5 parts, Semen Persicae, Rhizoma Curcumae 3 parts, Fructus Aurantii (parched) 3 parts, 3 parts, Radix Glycyrrhizae by following weight portion.
embodiment 3, prescription 3
The each raw material of the present invention is taken: Radix Bupleuri 20 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 15 parts, 20 parts, the Radix Rehmanniae, Caulis Spatholobi 20 parts, Fructus Gardeniae 12 parts, Radix Curcumae 20 parts, Rhizoma Sparganii 9 parts, 15 parts, Semen Persicae, Rhizoma Curcumae 9 parts, Fructus Aurantii (parched) 9 parts, 12 parts, Radix Glycyrrhizae by following weight portion.
embodiment 4, prescription 4
The each raw material of the present invention is taken: Radix Bupleuri 20 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Chuanxiong 15 parts, 10 parts, the Radix Rehmanniae, Caulis Spatholobi 20 parts, Fructus Gardeniae 3 parts, Radix Curcumae 20 parts, Rhizoma Sparganii 3 parts, 15 parts, Semen Persicae, Rhizoma Curcumae 3 parts, Fructus Aurantii (parched) 9 parts, 3 parts, Radix Glycyrrhizae by following weight portion.
embodiment 5, prescription 5
The each raw material of the present invention is taken: Radix Bupleuri 8 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 5 parts, 20 parts, the Radix Rehmanniae, Caulis Spatholobi 10 parts, Fructus Gardeniae 12 parts, Radix Curcumae 10 parts, Rhizoma Sparganii 9 parts, 5 parts, Semen Persicae, Rhizoma Curcumae 9 parts, Fructus Aurantii (parched) 3 parts, 12 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology: the dry medicine raw material getting ingredients in prescription, removing impurity, cleans, drying, uses cold water soak 30min, boils 10min, filtering medicinal residues extracting juice, medicinal residues repeat above-mentioned technique once, mix twice filtrate, namely decoction is obtained after cooling, every milliliter of medicinal liquid contains crude drug amount 0.1g, 1 dose/day, when being used for the treatment of chloasma, sooner or later each decoction being taken warmly 1 time after meal, each 150mL.Those skilled in the art can also add adjuvant conventional formulation technique on this basis can obtain the conventional oral formulations such as mixture, tablet, capsule, granule or powder.
the clinical data of embodiment 6 Chinese medicine preparation treatment of the present invention chloasma
One, case-data: the 220 routine women's qi stagnation and blood stasis type patients meeting Screening Diagnosis standard choosing hospital's Dermatology and outpatient service, as object of study, meet with symptom: yellowish-brown patch appears in face, soreness of the waist and knees, or being irritable and getting angry easily, distending pain in the chest and hypochondrium.Dark tongue quality, white and thin fur, deep-thready pulse.Be divided into treatment group and matched group at random.
Treatment group 110 example, age 23-48 year, the mean age (28.3 ± 4.1) year; The course of disease 8 months-9 years, average course of disease (3.7 ± 2.7) year.Matched group 110 example, year 21-46 year, the mean age (29.1 ± 4.4) year; The course of disease 10 months-9 years, average course of disease (3.5 ± 2.8) year.Two groups of patient's physical data no significant differences, P>0.05, has comparability.
Two, diagnostic criteria:
1, diagnosis basis:
1) facial skin lesion is black speck, puts down in skin, and color is as dust and dirt, and light brown or light black, without pain of itching.
2) facial areas such as volume, eyebrow, cheek, bridge of the nose, lip are often occurred in.
3) be more common in woman, onset has chronic process.
4) tissue pathology checking shows hyperpigmentation in epidermis, also has more pigment in corium addicted to melanocyte.Minority lymphocytic infiltration can be had at blood vessel and perifollicolar.
2, case selection:
1) age is between 20-55 year;
2) without Diseases such as serious endocrine;
3) to medicine without allergies person;
4) without gestation or women breast-feeding their children.
3, to reject and the standard that comes off
1) experimenter's compliance is poor, does not treat by doctor's advice;
2) data is incomplete, affects the treatment or safety judgement person;
3) because of untoward reaction discontinue medication person;
4) there is anaphylaxis, serious adverse events and special physiological change palpus stopped treatment person in therapeutic process;
5) can not the tolerate treatment person of dropping by the wayside in research process;
6) treatments period, takes other treatment medicine, likely the Study of Interference result person;
7) other clinical trial persons are participated in.
Three, usage and dosage:
Treatment group: get Radix Bupleuri 14g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 10g, Radix Rehmanniae 15g, Caulis Spatholobi 15g, Fructus Gardeniae 8g, Radix Curcumae 15g, Rhizoma Sparganii 6g, Semen Persicae 10g, Rhizoma Curcumae 6g, Fructus Aurantii (parched) 6g, Radix Glycyrrhizae 8g, use cold water soak 30min, boil 10min, filtering medicinal residues extracting juice, medicinal residues repeat above-mentioned technique once, mix twice filtrate, after cooling, extracting juice 300ml(every milliliter of medicinal liquid is containing crude drug amount 0.1g), 1 dose/day, early, each decoction being taken warmly 1 time after supper, each 150ml.
Matched group: PAIDU YANGYAN JIAONANG (the accurate word Z53020685 of traditional Chinese medicines) 0.8g, every day 2 times, oral.
Two groups was all a course for the treatment of with 4 weeks, judged curative effect after treating 1 course for the treatment of.Period in a medicine polyphagia fruit, vegetable, drink plain boiled water more, and fasting or few edible oil explode, pungent irritating food.
Four, criterion of therapeutical effect:
The chloasma criterion of therapeutical effect of revision in 2003 is organized with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease.
Cure: naked eyes disappear depending on mottle area and are greater than 90%, and color disappears substantially.
Effective: meat is greater than 60% with disappearing depending on mottle area, and color is obviously thin out.
Take a turn for the better: naked eyes disappear depending on mottle area, and to be greater than 30%. colors thin out.
Invalid: naked eyes disappear depending on mottle area and are less than 30%, color change is not obvious.
Total effective rate=(cure+effective+effectively)/total number of cases × 100%
Five, therapeutic effect:
The treatment total effective rate for the treatment of group is 97.27%, and matched group is 74.45%, visible, and the treatment total effective rate for the treatment of group is apparently higher than matched group, and P<0.05, has statistical significance, and two groups all do not occur serious untoward reaction.Concrete outcome, in table 1, shows to use Chinese medicine preparation of the present invention to treat chloasma determined curative effect, safe and reliable, can be used as the effective ways for the treatment of chloasma.
The comparitive study of table 1. treatment group and matched group
| Group | Cure | Effective | Effectively | Invalid | Total effective (rate) |
| Treatment group | 48 | 36 | 23 | 3 | 107（97.27%） |
| Matched group | 18 | 22 | 42 | 28 | 82（74.45%） |
Claims (6)
1. the purposes of Chinese medicine preparation in preparation treatment qi stagnation and blood stasis type chloasma medicine, it is characterized in that, described Chinese medicine preparation is obtained by following raw material:
Radix Bupleuri, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Rehmanniae, Caulis Spatholobi, Fructus Gardeniae, Radix Curcumae, Rhizoma Sparganii, Semen Persicae, Rhizoma Curcumae, Fructus Aurantii (parched), Radix Glycyrrhizae.
2. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is obtained by the raw material of following weight portion:
Radix Bupleuri 7-21 part, Radix Salviae Miltiorrhizae 9-21 part, Rhizoma Chuanxiong 4-16 part, Radix Rehmanniae 9-21 part, Caulis Spatholobi 9-21 part, Fructus Gardeniae 2-13 part, Radix Curcumae 9-21 part, Rhizoma Sparganii 2-10 part, Semen Persicae 4-16 part, Rhizoma Curcumae 2-10 part, Fructus Aurantii (parched) 2-10 part, Radix Glycyrrhizae 2-13 part.
3. purposes as claimed in claim 2, it is characterized in that, described Chinese medicine preparation is obtained by the raw material of following weight portion:
Radix Bupleuri 14 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Chuanxiong 10 parts, 15 parts, the Radix Rehmanniae, Caulis Spatholobi 15 parts, Fructus Gardeniae 8 parts, Radix Curcumae 15 parts, Rhizoma Sparganii 6 parts, 10 parts, Semen Persicae, Rhizoma Curcumae 6 parts, Fructus Aurantii (parched) 6 parts, 8 parts, Radix Glycyrrhizae.
4. the purposes as described in as arbitrary in claim 1-3, it is characterized in that, described Chinese medicine preparation is oral formulations.
5. purposes as claimed in claim 3, it is characterized in that, described oral formulations is decoction, tablet, capsule, granule or powder.
6. purposes as claimed in claim 5, it is characterized in that, described oral formulations is decoction.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213668A (en) * | 2015-10-31 | 2016-01-06 | 孙太辉 | A kind of medicine for the treatment of chloasma faciei and preparation method thereof |
| CN105596733A (en) * | 2016-03-16 | 2016-05-25 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine preparation in preparation of medicine for treating chloasma caused by qi-stagnation and blood stasis |
| CN105641426A (en) * | 2016-03-16 | 2016-06-08 | 烟台市蓝洋之草医药生物科技有限公司 | Chinese herbal preparation for treating qi and blood stagnation type chloasma |
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| CN101269205A (en) * | 2008-05-08 | 2008-09-24 | 北京天科仁祥医药科技有限公司 | Medicament combination for recuperating qi-blood, dissolving stasis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101269205A (en) * | 2008-05-08 | 2008-09-24 | 北京天科仁祥医药科技有限公司 | Medicament combination for recuperating qi-blood, dissolving stasis and preparation method thereof |
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| 叶建洪: "《家庭医疗保健丛书（第一辑）•皮肤病》", 31 May 2003 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213668A (en) * | 2015-10-31 | 2016-01-06 | 孙太辉 | A kind of medicine for the treatment of chloasma faciei and preparation method thereof |
| CN105596733A (en) * | 2016-03-16 | 2016-05-25 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine preparation in preparation of medicine for treating chloasma caused by qi-stagnation and blood stasis |
| CN105641426A (en) * | 2016-03-16 | 2016-06-08 | 烟台市蓝洋之草医药生物科技有限公司 | Chinese herbal preparation for treating qi and blood stagnation type chloasma |
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Application publication date: 20150325 |