CN107149641A - A kind of composition for being used to treat burn and scald - Google Patents
A kind of composition for being used to treat burn and scald Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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Abstract
The invention discloses a kind of composition for being used to treat burn and scald.The active component of composition is made up of alkannin, burn and scald compound alcohol extract and burn and scald compound water extract, wherein, the burn and scald compound alcohol extract is the alcohol extracting thing of frankincense, indigo naturalis and Resina Draconis, and the burn and scald compound water extract is the water extract of the coptis, Rumex madaio, corydalis tuber, garden burnet and Golden Larch Bark.The percentage by weight that described alkannin accounts for composition is 0.01~0.3%；The percentage by weight that the burn and scald alcohol extract accounts for composition is 0.5~5%；The percentage by weight that the burn and scald compound water extract accounts for composition is 0.2~12%.The present invention combines modern production process based on traditional secret recipe, and the active ingredient to kinds of traditional Chinese medicines material carries out extraction processing.In the case of not any side effect, healing to the full extent eliminates and scar and reduces infection, has good therapeutic effect to burn and scald, it is to avoid the excitant of modern chemistry medicament and traditional Chinese medicine compound preparation in-convenience in use.
Description
Technical field
Carried the invention belongs to biological medicine and therapeutic make-up technique field, more particularly to one kind containing alkannin and Chinese medicine
Take thing be used for treat burn and scald composition and Some dosage forms preparation method.
Background technology
Burn and scald is a kind of common disease, and many patients are annoying for a long time.Burn and scald is the fire damage of skin, heat
Poison is suffers from, therefore, how to protect the surface of a wound, reduction to ooze out, prevents infection to be the subject matter for needing to solve.And treat burn and scald
Principle is exactly clearing heat and detoxicating, cooling and activating blood, clearing damp and promoting diuresis, supplementing qi and nourishing yin.
The types of drugs for the treatment of burn and scald is more at present, is basically divided into Chinese medicine and Western medicine, is risen by burnt degree
Bubble, skin break, fester after treatment passive not in time, bring great pain to patient, economic loss and worry caused to family
Fatigue, or even maimed and outward appearance can be caused to lose beautiful huge psychological pressure；In addition, the raw material of Western medicine is generally chemical substance, effect
It is single, and or stimulation can be produced to application on human skin, some long-term uses have dependence or have side effect.Traditional Chinese medicine controls burn outside
Aspect has rich experience, and the theoretical level for controlling burn outside traditional Chinese medicine in recent years is improved constantly, and clinical experience is enriched constantly, clinical excellent
Gesture is more and more obvious.
There is the utilization of many advantages, especially Chinese medicine compound prescription, clinical and experiment in terms of skin disease is treated in Chinese Drug Zicao
Research confirm Asian puccoon there is anti-inflammatory, it is antibacterial, antipruritic and the effects such as repair, be mainly used in burn, eczema and various skin diseases, especially
In the healing of its foot ulcer wound caused in treatment diabetes, effect is fine.It is subjected to many patients and skin
The favor of section doctor.The main pharmacodynamics composition of Asian puccoon is alkannin (shikonin), also known as 5,8- dihydroxy -2- [(1R) -1- hydroxyls
The amyl- 3- alkenyls of base -4- methyl] naphthalene-Isosorbide-5-Nitrae-diketone, it is distinctive a kind of fat-soluble Naphthaquinone Pigments class compound in Asian puccoon, but it is purple
Chemical composition containing referred to as pyrrolizidine alkaloids class in grass, abbreviation PAs, toxicity concentrates on liver, also known as liver poison
Pyrrolizidine alkaloid, is that clinical practice leaves hidden danger.
The coptis, garden burnet and Rumex madaio etc. are all the good medicine for the treatment of burn and scald in traditional Chinese medicine.According to《Chinese Pharmacopoeia》、《In
Medicine voluminous dictionary》And《Chinese book on Chinese herbal medicine》Record, the coptis has heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating, for skin sore, eczema
And the burning hot wound of soup, jamaicin in the coptis bactericidal and can play the effect such as gentle calmness, be that the protection surface of a wound prevents infection
Effective barrier, while the sedation that medicine is produced after the surface of a wound is absorbed by tissue can effectively mitigate patient suffering；Garden burnet contains
A large amount of tannins, have stronger convergence and pressor effect, it is possible to decrease the permeability of capillary, reduce inflammatory ooze out,
Mitigate tissue edema.Its cooling blood and hemostasis, the function of sore removing toxic substances, can play prevention and infection control, eliminate pain, promote the surface of a wound
The effects such as rapid healing；Rumex madaio can clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body is particularly suitable for for treating burn and scald, the property of Rumex madaio
Excessive secretion clearing that is cold and cool, rapidly can producing the heat toxin and body that scald position under the stimulation of heat toxin, skin is
It is able to heal and preventing from scar quickly.
The Chinese patent literature of Application No. 201110249919.0 discloses a kind of liquid for curing scald and burn, ointment for treating burn and scald and its system
Preparation Method, its described liquid for curing scald and burn is to beat the medicinal materials such as giant knotweed, Asian puccoon, raw cape jasmine, phellodendron bark after powder with one or two of ethanol immersion
Month, filtered when using, add a small amount of Moschus.The liquid for curing scald and burn, which is prepared, needs the long period, and application method is not convenient enough, and
Ethanol has larger excitant to the skin of damage, and larger pain can be brought to patient.Its described ointment for treating burn and scald be by Asian puccoon,
The medicinal materials such as the root of Dahurain angelica, Radix Angelicae Sinensis, radix glycyrrhizae, rheum officinale, golden cypress beat powder, using sesame oil as matrix, and finished product need to be stored refrigerated, and being remained unchanged when using will
Add a small amount of Moschus.It is not convenient enough that the ointment for treating burn and scald application method remains unchanged.
The content of the invention
Goal of the invention：In order to safely and effectively treat burn and scald, the invention provides a kind of novel formula, evident in efficacy
Composition containing alkannin and Chinese medical extract.Present invention also offers the preparation method of Some dosage forms.
Technical scheme：A kind of composition for being used to treat burn and scald, active component is by alkannin, burn and scald compound alcohol extract
Constituted with burn and scald compound water extract, wherein, the burn and scald compound alcohol extract is the alcohol extracting of frankincense, indigo naturalis and Resina Draconis
Thing, the burn and scald compound water extract is the water extract of the coptis, Rumex madaio, corydalis tuber, garden burnet and Golden Larch Bark.
The coptis has a heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating, for skin sore, eczema and the burning hot wound of soup, in the coptis
Jamaicin can bactericidal and play gentle calmness etc. effect；Rumex madaio can clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body is particularly suitable for for controlling
Burn and scald is treated, its rheum emodin contained has antibacterial, anti-inflammatory, the effect of anti-inflammatory；Corydalis tuber also known as corydalis tuber, there is promoting blood circulation to remove blood stasis, reason
Effect of gas analgesic, proposes that alkaloid more than 10 is planted altogether in its plant tuber, and these alkaloids have certain anti-inflammatory and antibacterial
Effect；Garden burnet contains a large amount of tannins, and garden burnet contains a large amount of tannins, there is stronger convergence and pressor effect, it is possible to decrease
The permeability of capillary, reduces inflammatory and oozes out, mitigates tissue edema, its cooling blood and hemostasis, the function of sore removing toxic substances can be played pre-
Anti- and infection control, elimination pain, the effect such as healing rapidly of the promotion surface of a wound；Golden Larch Bark has the antipruritic effect of dispelling wind and eliminating dampness, desinsection,
Pseudo laric acid B is mainly contained, with the effect such as antimycotic, antitumor, antifertility, anti-angiogenesis.Above composition water can be with
Extract active ingredient.
Frankincense has functions that blood-activating and qi-promoting analgesic, detumescence and promoting granulation, its extract and the triterpenes components boswellic acids contained
Compound is respectively provided with anti-inflammatory activity to various acute and chronic inflammation model；Indigo naturalis has functions that heat-clearing, cool blood, removing toxic substances, mainly
Containing compositions such as indigo, indigo red, couroupitine As, wherein couroupitine A is to microsporum lanosum, trichophyton tonsurans, gypsum sample microspore
7 kinds of dermatophytes such as bacterium, purple tinea bacterium have stronger bacteriostasis；Resina Draconis has promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, sore life
Effect of flesh, containing flavone compound, Pterostilbene, resveratrol, 3-(2,4-Dimethoxy-phenyl)-1-(4-hydroxy-phenyl)-propan-1-one etc., to staphylococcus aureus, white grapes
Coccus, Staphylococcus citreus, Nai Shi coccuses, corynebacterium diphtheriae, shigella flexneri have certain inhibitory action.These three medicinal materials
Active ingredient can be taken out with alcohol extracting.
Above medicinal material has synergy in terms of burn and scald is treated.The antibacterial, anti-inflammatory of the energy such as the coptis, Rumex madaio, prevents wound
Place's infection；Garden burnet, frankincense etc. can reduce inflammation swelling and pain relieving, promote wound healing.Therefore respectively through alcohol extracting and water extraction after, simultaneously
Addition can preferably play therapeutic efficiency.
In the burn and scald compound alcohol extract, by weight percentage, raw material composition is：
10~12 parts of frankincense
15~20 parts of indigo naturalis
4~6 parts of Resina Draconis.
The preparation method of the burn and scald compound alcohol extract includes：
Extracted 2~4 times with the ethanol of 5~10 times of volume ratios after described frankincense, indigo naturalis, Resina Draconis are mixed, ethanol is pure
Spend for 80~100%, Extracting temperature is 70~90 DEG C, extraction time is 1~3 hour, extraction terminates rear merging filtrate, concentration is dry
It is dry to obtain the burn and scald compound alcohol extract.
In the burn and scald compound water extract, by weight percentage, raw material composition is：
The preparation method of the burn and scald compound water extract includes：
After the described coptis, Rumex madaio, corydalis tuber, garden burnet and Golden Larch Bark are mixed with the water extractions 2 of 5~10 times of volume ratios~
4 times, Extracting temperature is 70~90 DEG C, and extraction time is 1~3 hour, and extraction terminates rear merging filtrate, and concentrate drying obtains described
Burn and scald compound water extract.
Preferably, in the extraction process of above-mentioned burn and scald compound alcohol extract and burn and scald compound water extract, the ethanol
Purity is 90%, and the temperature of alcohol extracting and water extraction is 85 DEG C, and the time extracted every time is 2 hours, is extracted respectively twice, you can fully
Extract active ingredient.
Composition of the present invention, in addition to the active ingredient (s, also containing being subjected to matrix and auxiliary material in pharmaceutically or cosmetically,
The products such as gel, emulsifiable paste, cream, suspension, emulsion are made.
Alternatively, the percentage by weight that described alkannin accounts for composition is 0.01~0.3%；The burn and scald alcohol extract
Account for composition percentage by weight be 0.5~5%, equivalent to frankincense 0.1~2%, indigo naturalis 0.2~3%, Resina Draconis 0.05~
1%；The burn and scald compound water extract account for composition percentage by weight be 0.2~12%, equivalent to the coptis 0.02~3%,
Rumex madaio 0.04~4.5%, corydalis tuber 0.03~3.5%, garden burnet 0.02~3.5%, Golden Larch Bark 0.02~3.5%.
Preferably, the percentage by weight that described alkannin accounts for composition is 0.02~0.1%；Described burn and scald compound
The percentage by weight that alcohol extract accounts for composition is 0.5~2%, and the percentage by weight that burn and scald compound water extract accounts for composition is
0.5~2%.
Alternatively, described matrix is the one or more in gelatum skeleton material, oil phase substrate and emulsifying agent；Described
Auxiliary material includes the one or more in solubilizer, NMF, pH adjusting agent, enhancer of cutaneous penetration and water；Described auxiliary material also includes
One or more in disinfectant, preservative, antioxidant and essence.
Alternatively, when formulation is gel, selected gelatum skeleton material is that carbomer series, cellulose derivative, shell are poly-
At least one of carbohydrate matrix；When formulation is cream, selected oil phase substrate is vegetable oil, higher aliphatic, beeswax, tristearin
At least one of acid；Selected emulsifying agent is at least one in the fatty acid ester, fatty alcohol, polyethenoxy ether class of polyalcohol
Kind.
Preferably, when formulation is gel, selected gelatum skeleton material is carbomer U10, carbomer U20, ethoxy fibre
Tie up at least one of element.
Alternatively, solubilizer is at least one of Families of poloxamers, TWEEN Series, and Families of poloxamers includes pool Lip river
Husky nurse 188, poloxamer188；NMF is glycerine, propane diols, 1,3 butylene glycol, sorbierite, pyrrolidone sodium carboxylate, transparent
At least one of matter acid, lactic acid and sodium lactate；Disinfectant is triclosan, parachlorometaxylenol, chlorhexidine acetate, poly- six Asia
At least one of methyl biguanides.
Alternatively, NMF accounts for the 5~20% of gross weight, and enhancer of cutaneous penetration accounts for the 0.3~5% of gross weight, and preservative is accounted for
The 0.05~0.5% of gross weight, antioxidant accounts for the 0.2~1% of gross weight, and essence accounts for 0.02~2%, the pH regulations of gross weight
Agent accounts for the 0.1~2% of gross weight, and disinfectant accounts for the 0.05~1% of gross weight；When formulation is gel, gelatum skeleton material is accounted for
The 0.25~2% of gross weight；When formulation is cream, emulsion, emulsifying agent accounts for the 0.5~10% of gross weight.
When formulation is cream, by weight percentage, the composition of composition is：Alkannin, 0.01~0.3%；Third
Glycol, 2~4%；Chlorhexidine acetate, 0.1~0.3%；M-68 emulsifying agents, 2~10%, peregal O-25,1~3%；18
Alcohol, 0.5~3%；PEG-60 rilanit specials, 5~10%；Isopropyl myristate, 2~10%；Oil-soluble VE, 0.1~
0.3%；Saualane, 2~6%；Olive oil, 2~10%；Burn and scald compound alcohol extract, 0.5~5%；Ethanol, 0.5~5%；It is sweet
Oxalic acid dipotassium, 0.1~0.5%；Hyaluronic acid, 0.1~0.3%；EDTA-2Na, 0.01~0.05%；Citric acid, 0.01~
0.05%；Burn and scald compound water extract, 0.2~12%；Surplus is water；Wherein, the mass concentration of hyaluronic acid is 1~2%；
When formulation is gel, by weight percentage, the composition of composition is：Alkannin, 0.01~0.3%；Third
Glycol, 2~4%；PLURONICS F87,2~6%；Triclosan, 0.1~0.3%；Glycerine, 10~30%；Carbomer U20,0.2
~0.8%；Xanthan gum, 0.1~0.5%；Burn and scald water extract, 0.2~12%；Burn and scald alcohol extract, 0.5~5%；Three ethanol
Amine, 2~10%；Surplus is water；Wherein, the mass concentration of triethanolamine is 8~10%.
Preferably, when formulation is cream, by weight percentage, the composition of composition is：Alkannin, 0.02%；
Propane diols, 4%；Chlorhexidine acetate, 0.3%；M-68 emulsifying agents, 10%, peregal O-25,2%；Octadecyl alcolol, 1%；PEG-60
Rilanit special, 10%；Isopropyl myristate, 9.5%；Oil-soluble VE, 0.2%；Saualane, 5%；Olive oil, 5%；Burn
Scald compound alcohol extract, 0.5~2%；Ethanol, 2%；Dipotassium glycyrrhizinate, 0.2%；Hyaluronic acid, 0.15%；EDTA-2Na,
0.025%；Citric acid, 0.025%；Burn and scald compound water extract, 0.5~2%；Surplus is water.
Preferably, when formulation is gel, by weight percentage, the composition of composition is：Alkannin, 0.02%；
Propane diols, 2%；PLURONICS F87,4%；Triclosan, 0.15%；Glycerine, 20%；Carbomer U20,0.6%；Xanthan gum,
0.25%；Burn and scald water extract, 0.5~2%；Burn and scald alcohol extract, 0.5~2%；Triethanolamine, 3%；Surplus is water.
Present invention also offers the preparation method of the composition Some dosage forms, including：
Cream：By weight, by M-68 emulsifying agents, peregal O-25, octadecyl alcolol, PEG-60 rilanit specials, Pork and beans
Cool isopropyl propionate, oil-soluble VE, saualane, olive oil mixing, are heated, fusing, stirring is equal in 75~80 DEG C or so water-baths
Even, the chlorhexidine acetate that the burn and scald compound alcohol extract and propane diols that addition is dissolved by heating with ethanol are dissolved by heating makes into oil phase A；
Dipotassium glycyrrhizinate, hyaluronic acid, EDTA-2Na, citric acid, burn and scald compound water extract are dissolved in purified water, on 75~85 DEG C of left sides
Heated in right water-bath, stir, make into aqueous phase B.A and B is pumped into homogeneous pot, 70~80 DEG C of constant temperature and homogeneous is kept,
After fully emulsified, stir and be progressively cooled to 40~45 DEG C, the alkannin of addition propane diols room temperature ultrasonic dissolution continues to stir
Mix, it is uniform after be cooled to room temperature, it is filling；
Gel：By weight, take carbomer U20 water-dispersible, be heated to 75~85 DEG C, be stirring evenly and then adding into pool Lip river
Husky nurse 188, triclosan, glycerine, xanthan gum, burn and scald compound water extract, burn and scald compound alcohol extract, continue stirring until dissolving equal
It is even, room temperature is cooled to, the alkannin of propane diols room temperature ultrasonic dissolution is added, is slowly stirred, adds triethanolamine, is filled after stirring evenly
Dress.
Composition of the present invention is used as the medicine or cosmetics of percutaneous effects, available for treatment burn, is scalded.
Compared with prior art, beneficial effects of the present invention include：
The active component that the present composition contains is derived from natural plants, extracts and is added to by rational technique
In matrix medicinal or used for cosmetic, the stabilised quality and traditional Chinese medicine for inheriting modern medicine preparation or cosmetic product are gently effective
Treatment skill, the medicine or cosmetics of a kind of convenient use, novel formula are provided on treatment burn and scald field.
The present invention combines modern production process based on traditional secret recipe, and the active ingredient to kinds of traditional Chinese medicines material is extracted
Processing.In the case of not any side effect, healing to the full extent eliminates scar and reduces infection, has to burn and scald good
Good therapeutic effect, it is to avoid the excitant of modern chemistry medicament and traditional Chinese medicine compound preparation in-convenience in use.
The present composition preparation process cycle is short, and application method is simple and convenient.
In summary, the present invention by that multinomial technology will carry out effective integration above, and realizing to extract in Chinese medicine has
Imitate composition and applied to inexpensive, few step, low-loss and the environmental protection production of modern medicine preparation or cosmetics, control curative effect
Really good, the market competitiveness is strong, has a extensive future.
Embodiment
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention, after the present invention has been read, various equivalences of the those skilled in the art to the present invention
The modification of form falls within the application appended claims limited range.
In the specific embodiment of the invention,
The preparation method of burn and scald compound alcohol extract is as follows：
6 parts of 12 parts of frankincense, 20 parts of indigo naturalis and Resina Draconis are weighed by weight, and 2 are extracted with the ethanol of 8 times of volume ratios after mixing
Secondary, purity of alcohol is 90%, and Extracting temperature is 85 DEG C, and the time is 2 hours, and extraction terminates rear merging filtrate, and concentrate drying is obtained
Burn and scald compound alcohol extract.
The preparation method of burn and scald compound water extract is as follows：
16 parts of the coptis, 20 parts of Rumex madaio, 20 parts of corydalis tuber, 20 parts of garden burnet, 20 parts of Golden Larch Bark are weighed by weight, are used after mixing
The purified water of 8 times of volume ratios is extracted 2 times, and Extracting temperature is 85 DEG C, and the time is 2 hours, and extraction terminates rear merging filtrate, and concentration is dry
It is dry to obtain burn and scald compound water extract.
Embodiment 1：A kind of composition and cream for burn and scald
Formula components (100g), by percentage to the quality, constitute and are：Alkannin, 0.02%；Propane diols, 4%；Acetic acid chlorine
Oneself determines, and 0.3%；M-68 emulsifying agents, 10%, peregal O-25,2%；Octadecyl alcolol, 1%；PEG-60 rilanit specials, 10%；Meat
Isopropyl myristate, 9.5%；Oil-soluble VE, 0.2%；Saualane, 5%；Olive oil, 5%；Burn and scald compound alcohol extract,
0.5%；Ethanol, 2%；Dipotassium glycyrrhizinate, 0.2%；Hyaluronic acid (1%, mass concentration), 0.15%；EDTA-2Na,
0.025%；Citric acid, 0.025%；Burn and scald compound water extract, 0.5%；Purified water adds to 100g.
Preparation method：M-68 emulsifying agents, peregal O-25, octadecyl alcolol, PEG-60 rilanit specials, myristic acid isopropyl
Ester, oil-soluble VE, saualane, olive oil mixing, are heated in 80 DEG C or so water-baths, and fusing stirs, and adds burn and scald
Compound alcohol extract (ethanol heating for dissolving) and chlorhexidine acetate (propane diols 2g heating for dissolving) make into oil phase A；By dipotassium glycyrrhizinate,
Hyaluronic acid, EDTA-2Na, citric acid, burn and scald compound water extract are dissolved in purified water, heat, stir in 80 DEG C or so water-baths
Mix uniform, make into aqueous phase B.A and B is pumped into homogeneous pot, 70~80 DEG C of constant temperature and homogeneous is kept, after fully emulsified, stirring
And be progressively cooled to 40 DEG C, add alkannin (propane diols 2g room temperatures ultrasonic dissolution), continue to stir, it is uniform after be cooled to room temperature,
It is filling, produce cream.
Embodiment 2：A kind of composition and cream for burn and scald
Formula components (100g), by percentage to the quality, constitute and are：Alkannin, 0.02%；Propane diols, 4%；Acetic acid chlorine
Oneself determines, and 0.3%；M-68 emulsifying agents, 10%, peregal O-25,2%；Octadecyl alcolol, 1%；PEG-60 rilanit specials, 10%；Meat
Isopropyl myristate, 9.5%；Oil-soluble VE, 0.2%；Saualane, 5%；Olive oil, 5%；Burn and scald compound alcohol extract, 1%；
Ethanol, 2%；Dipotassium glycyrrhizinate, 0.2%；Hyaluronic acid (1%, mass concentration), 0.15%；EDTA-2Na, 0.025%；Lemon
Acid, 0.025%；Burn and scald compound water extract, 1%；Purified water adds to 100g.
Preparation method：M-68 emulsifying agents, peregal O-25, octadecyl alcolol, PEG-60 rilanit specials, myristic acid isopropyl
Ester, oil-soluble VE, saualane, olive oil mixing, are heated in 80 DEG C or so water-baths, and fusing stirs, and adds burn and scald
Compound alcohol extract (ethanol heating for dissolving) and chlorhexidine acetate (propane diols 2g heating for dissolving) make into oil phase A；By dipotassium glycyrrhizinate,
Hyaluronic acid, EDTA-2Na, citric acid, burn and scald compound water extract are dissolved in purified water, heat, stir in 80 DEG C or so water-baths
Mix uniform, make into aqueous phase B.A and B is pumped into homogeneous pot, 70~80 DEG C of constant temperature and homogeneous is kept, after fully emulsified, stirring
And be progressively cooled to 40 DEG C, add alkannin (propane diols 2g room temperatures ultrasonic dissolution), continue to stir, it is uniform after be cooled to room temperature,
It is filling, produce cream.
Embodiment 3：A kind of composition and cream for burn and scald
Formula components (100g), by percentage to the quality, constitute and are：Alkannin, 0.02%；Propane diols, 4%；Acetic acid chlorine
Oneself determines, and 0.3%；M-68 emulsifying agents, 10%, peregal O-25,2%；Octadecyl alcolol, 1%；PEG-60 rilanit specials, 10%；Meat
Isopropyl myristate, 9.5%；Oil-soluble VE, 0.2%；Saualane, 5%；Olive oil, 5%；Burn and scald compound alcohol extract, 2%；
Ethanol, 2%；Dipotassium glycyrrhizinate, 0.2%；Hyaluronic acid (1%, mass concentration), 0.15%；EDTA-2Na, 0.025%；Lemon
Acid, 0.025%；Burn and scald compound water extract, 2%；Purified water adds to 100g.
Preparation method：M-68 emulsifying agents, peregal O-25, octadecyl alcolol, PEG-60 rilanit specials, myristic acid isopropyl
Ester, oil-soluble VE, saualane, olive oil mixing, are heated in 80 DEG C or so water-baths, and fusing stirs, and adds burn and scald
Compound alcohol extract (ethanol heating for dissolving) and chlorhexidine acetate (propane diols 2g heating for dissolving) make into oil phase A；By dipotassium glycyrrhizinate,
Hyaluronic acid, EDTA-2Na, citric acid, burn and scald compound water extract are dissolved in purified water, heat, stir in 80 DEG C or so water-baths
Mix uniform, make into aqueous phase B.A and B is pumped into homogeneous pot, 70~80 DEG C of constant temperature and homogeneous is kept, after fully emulsified, stirring
And be progressively cooled to 40 DEG C, add alkannin (propane diols 2g room temperatures ultrasonic dissolution), continue to stir, it is uniform after be cooled to room temperature,
It is filling, produce cream.
Embodiment 4：A kind of composition and gel for burn and scald
Formula components (100 grams), by percentage to the quality, constitute and are：Alkannin, 0.02%；Propane diols, 2%；Moor Lip river husky
Nurse 188,4%；Triclosan, 0.15%；Glycerine, 20%；Carbomer U20,0.6%；Xanthan gum, 0.25%；Burn and scald compound water
Extract, 0.5%；Burn and scald compound alcohol extract, 0.5%；Triethanolamine (10%, mass concentration), 3%；Purified water, is added to
100g。
Preparation method：Carbomer U20 is scattered with appropriate purified water, is heated to 80 DEG C or so, is stirring evenly and then adding into pool Lip river
Husky nurse 188, triclosan, glycerine, xanthan gum, burn and scald water extract, burn and scald alcohol extract, continue stirring until and are uniformly dissolved.Cooling
To room temperature, alkannin (propane diols room temperature ultrasonic dissolution) is added, is slowly stirred, adds triethanolamine.Stir evenly rear filling produce
Gel.
Embodiment 5：A kind of composition and gel for burn and scald
Formula components (100 grams), by percentage to the quality, constitute and are：Alkannin, 0.02%；Propane diols, 2%；Moor Lip river husky
Nurse 188,4%；Triclosan, 0.15%；Glycerine, 20%；Carbomer U20,0.6%；Xanthan gum, 0.25%；Burn and scald compound water
Extract, 1%；Burn and scald compound alcohol extract, 1%；Triethanolamine (10%, mass concentration), 3%；Purified water, adds to 100g.
Preparation method：Carbomer U20 is scattered with appropriate purified water, is heated to 80 DEG C or so, is stirring evenly and then adding into pool Lip river
Husky nurse 188, triclosan, glycerine, xanthan gum, burn and scald water extract, burn and scald alcohol extract, continue stirring until and are uniformly dissolved.Cooling
To room temperature, alkannin (propane diols room temperature ultrasonic dissolution) is added, is slowly stirred, adds triethanolamine.Stir evenly rear filling produce
Gel.
Embodiment 6：A kind of composition and gel for burn and scald
Formula components (100 grams), by percentage to the quality, constitute and are：Alkannin, 0.02%；Propane diols, 2%；Moor Lip river husky
Nurse 188,4%；Triclosan, 0.15%；Glycerine, 20%；Carbomer U20,0.6%；Xanthan gum, 0.25%；Burn and scald compound water
Extract, 2%；Burn and scald compound alcohol extract, 2%；Triethanolamine (10%, mass concentration), 3%；Purified water, adds to 100g.
Preparation method：Carbomer U20 is scattered with appropriate purified water, is heated to 80 DEG C or so, is stirring evenly and then adding into pool Lip river
Husky nurse 188, triclosan, glycerine, xanthan gum, burn and scald water extract, burn and scald alcohol extract, continue stirring until and are uniformly dissolved.Cooling
To room temperature, alkannin (propane diols room temperature ultrasonic dissolution) is added, is slowly stirred, adds triethanolamine.Stir evenly rear filling produce
Gel.
Embodiment 7：Pharmaceutical composition fungistatic effect experiment of the present invention
Detection method：Bacterium to be measured and quantitative sample are coated with culture medium, using the culture medium of uncoated sample as right
According to.According to the number difference of surveyed bacterium after cultivating 48 hours, bacteriostasis rate is obtained.Concrete outcome such as following table：
The pharmaceutical composition fungistatic effect experiment of the present invention of table 1
| Group | To Escherichia coli bacteriostasis rate | To staphylococcus aureus bacteriostasis rate |
| Embodiment 1 | 73% | 76% |
| Embodiment 2 | 95% | 93% |
| Embodiment 3 | 100% | 100% |
| Embodiment 4 | 83% | 81% |
| Embodiment 5 | 96% | 95% |
| Embodiment 6 | 100% | 100% |
Embodiment 8：Medicine composite for curing Superficial bums of the present invention and deep II degree of burned patient clinical test
Case selection：Nanjing in January, 2017 is included altogether in May, 2017 burned patient 163.Man 87, female 76
Example, 4~71 years old age, average age 35 years old；It is divided into according to burn and scald reason：Boiling water burn 85, fire wound 78；According to burning
Scald degree is divided into：Superficial bums 74, deep II degree of burn and scald 89.
Treatment method：Superficial bums patient 74, is divided into 7 groups；Deep II degree of burn and scald 89, is divided into 7 groups.Treatment group 1
~3 are treated using the cream of the embodiment of the present invention 1~3 respectively；Treatment group 4~6 uses the gel of the embodiment of the present invention 4~6 respectively
Agent is treated, and sets regular western medicine ointment (boric acid zinc oxide borneol ointment) treatment to treat as a control group.Each administration group patient
Dosage is determined according to burn and scald area, by can whole flap coverages be defined.3 times a day, equal 1 course for the treatment of on the 7th, is used in conjunction 3
The course for the treatment of.Total effective rate is calculated with recovery from illness, effective and effective percentage.The surface of a wound recovers normal skin and is considered as recovery from illness, and the surface of a wound is noninductive
Dye be considered as it is effective, wound exudate swelling mitigate is considered as effectively.
The effective area %+0.3* effective areas % of cure rate %=recovery from illness area %+0.6*.
Efficacy evaluation is carried out after 3 courses for the treatment of of treatment.1 is the results are shown in Table, from pharmaceutical composition different pharmaceutical formulation pair of the present invention
From the point of view of the treatment of burned patient, each pharmaceutical composition different dosage forms effect in terms of cure rate is notable.
The present composition preparation for treating Superficial bums of table 2 and deep II degree of burned patient clinical test
Note：With control group ratio：*P<0.05, * * P<0.01.
Claims (10)
1. a kind of composition for being used to treat burn and scald, it is characterised in that active component is by alkannin, burn and scald compound alcohol extract
Constituted with burn and scald compound water extract, wherein, the burn and scald compound alcohol extract is the alcohol extracting of frankincense, indigo naturalis and Resina Draconis
Thing, the burn and scald compound water extract is the water extract of the coptis, Rumex madaio, corydalis tuber, garden burnet and Golden Larch Bark.
2. the composition according to claim 1 for being used to treat burn and scald, it is characterised in that the burn and scald compound alcohol extracting
In thing, by weight percentage, raw material composition is：
10~12 parts of frankincense
15~20 parts of indigo naturalis
4~6 parts of Resina Draconis；
In the burn and scald compound water extract, by weight percentage, raw material composition is：
3. the composition according to claim 1 for being used to treat burn and scald, it is characterised in that the burn and scald compound alcohol extracting
The preparation method of thing includes：After described frankincense, indigo naturalis, Resina Draconis are mixed 2~4 are extracted with the ethanol of 5~10 times of volume ratios
Secondary, purity of alcohol is 80~100%, and Extracting temperature is 70~90 DEG C, and extraction time is 1~3 hour, and extraction merges filter after terminating
Liquid, concentrate drying obtains the burn and scald compound alcohol extract.
The preparation method of the burn and scald compound water extract includes：By the described coptis, Rumex madaio, corydalis tuber, garden burnet and Golden Larch Bark
Extracted 2~4 times with the water of 5~10 times of volume ratios after mixing, Extracting temperature is 70~90 DEG C, and extraction time is 1~3 hour, is carried
Merging filtrate after end is taken, is concentrated and dried and obtains described burn and scald compound water extract.
4. the composition according to claim 1 for being used to treat burn and scald, it is characterised in that also containing pharmaceutically or cosmetically
In be subjected to matrix and auxiliary material.
5. the composition according to claim 4 for being used to treat burn and scald, it is characterised in that formulation is gel, emulsifiable paste, cream
Frost, suspension or emulsion.
6. the composition according to claim 1 for being used to treat burn and scald, it is characterised in that described alkannin accounts for combination
The percentage by weight of thing is 0.01~0.3%；The percentage by weight that the burn and scald alcohol extract accounts for composition is 0.5~5%；Institute
It is 0.2~12% to state burn and scald compound water extract and account for the percentage by weight of composition.
7. the composition according to claim 4 for being used to treat burn and scald, it is characterised in that described matrix is gel bone
One or more in frame material, oil phase substrate and emulsifying agent；Described auxiliary material is solubilizer, NMF, pH adjusting agent, skin
One or more in penetrating agent and deionized water；Described auxiliary material also includes in disinfectant, preservative, antioxidant and essence
One or more.
8. the composition according to claim 7 for being used to treat burn and scald, it is characterised in that when formulation is gel, institute
It is at least one of carbomer series, cellulose derivative, chitosan class matrix to select gelatum skeleton material；When formulation is cream
When, selected oil phase substrate is at least one of vegetable oil, higher aliphatic, beeswax, stearic acid；Selected emulsifying agent is polyalcohol
Fatty acid ester, fatty alcohol, at least one in polyethenoxy ether class.
9. the composition according to claim 4 for being used to treat burn and scald, it is characterised in that
When formulation is cream, by weight percentage, the composition of composition is：Alkannin, 0.01~0.3%；Propane diols,
2~4%；Chlorhexidine acetate, 0.1~0.3%；M-68 emulsifying agents, 2~10%, peregal O-25,1~3%；Octadecyl alcolol, 0.5
~3%；PEG-60 rilanit specials, 5~10%；Isopropyl myristate, 2~10%；Oil-soluble VE, 0.1~0.3%；Angle
Shark alkane, 2~6%；Olive oil, 2~10%；Burn and scald compound alcohol extract, 0.5~5%；Ethanol, 0.5~5%；Glycyrrhizic acid two
Potassium, 0.1~0.5%；Hyaluronic acid, 0.1~0.3%；EDTA-2Na, 0.01~0.05%；Citric acid, 0.01~0.05%；
Burn and scald compound water extract, 0.2~12%；Surplus is water；Wherein, the mass concentration of hyaluronic acid is 1~2%；
When formulation is gel, by weight percentage, the composition of composition is：Alkannin, 0.01~0.3%；Propane diols,
2~4%；PLURONICS F87,2~6%；Triclosan, 0.1~0.3%；Glycerine, 10~30%；Carbomer U20,0.2~
0.8%；Xanthan gum, 0.1~0.5%；Burn and scald water extract, 0.2~12%；Burn and scald alcohol extract, 0.5~5%；Three ethanol
Amine, 2~10%；Surplus is water；Wherein, the mass concentration of triethanolamine is 8~10%.
10. the composition according to claim 9 for being used to treat burn and scald, it is characterised in that the preparation method of cream
Including：By weight, by M-68 emulsifying agents, peregal O-25, octadecyl alcolol, PEG-60 rilanit specials, isopropyl myristate,
Oil-soluble VE, saualane, olive oil mixing, in 75~80 DEG C of heating, fusing stirs, addition is dissolved by heating with ethanol
The chlorhexidine acetate that burn and scald compound alcohol extract and propane diols are dissolved by heating makes into oil phase A；By dipotassium glycyrrhizinate, hyaluronic acid,
EDTA-2Na, citric acid, burn and scald compound water extract are dissolved in water, in 75~85 DEG C of heating, stir, make into aqueous phase B；By oil
Phase A and aqueous phase B are in 70~80 DEG C of constant temperature and homogeneous, after fully emulsified, stir and are progressively cooled to 40~45 DEG C, addition the third two
The alkannin of alcohol room temperature ultrasonic dissolution, continues to stir, it is uniform after be cooled to room temperature, it is filling；
The preparation method of gel includes：By weight, take carbomer U20 water-dispersible, be heated to 75~85 DEG C, stir
PLURONICS F87, triclosan, glycerine, xanthan gum, burn and scald compound water extract, burn and scald compound alcohol extract are added afterwards, are persistently stirred
Mix to being uniformly dissolved, be cooled to room temperature, add the alkannin of propane diols room temperature ultrasonic dissolution, stirring adds triethanolamine, stirred
It is even rear filling.
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|---|---|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108159203A (en) * | 2017-12-23 | 2018-06-15 | 董晓 | A kind of preparation method for the spray that scald is promoted to repair |
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| CN1092670A (en) * | 1993-03-27 | 1994-09-28 | 新疆维吾尔自治区药物研究所 | Burn ointment |
| CN104116925A (en) * | 2014-08-12 | 2014-10-29 | 杨闽 | Novel burn oil for treating burns and scalds |
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| CN1092670A (en) * | 1993-03-27 | 1994-09-28 | 新疆维吾尔自治区药物研究所 | Burn ointment |
| CN104116925A (en) * | 2014-08-12 | 2014-10-29 | 杨闽 | Novel burn oil for treating burns and scalds |
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| CN108159203A (en) * | 2017-12-23 | 2018-06-15 | 董晓 | A kind of preparation method for the spray that scald is promoted to repair |
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