CN104337862B - A Chinese medicinal composition for treating burn and scald, and its preparation method - Google Patents
A Chinese medicinal composition for treating burn and scald, and its preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to a pharmaceutical composition for treating burns and scalds and a preparation method of the pharmaceutical composition, belonging to the pharmaceutical chemical technology and relating to a pharmaceutical composition for treating burns and scalds and a preparation method of the pharmaceutical composition, which takes natural medicines as effective medicinal components. The invention relates to a pharmaceutical composition for treating burns and scalds and a preparation method of the medicine, and the medicine has the effects of detumescence, granulation promotion, dampness astringing, sore healing, granulation promotion, wound healing, antibiosis, inflammation diminishing, wound surface protection, infection prevention and wound rapid healing. The medicine composition for treating burns and scalds consists of common hydrangea rhizome and platycarya strobilacea; the preparation method comprises the following steps: taking the two medicinal materials of the common spiraea herb and the platycarya strobilacea as raw materials, mixing the two medicinal materials of the common spiraea herb and the platycarya strobilacea, adding water for extraction, filtering an extracting solution, concentrating a filtrate into an extract, and cooling to room temperature to obtain the medicine for treating the burn and the scald. The medicine has simple use method, does not treat the wound surface of a patient, can be applied immediately to relieve pain in a short time, and relieves or eliminates the pain.
Description
Technical Field
The invention belongs to the pharmaceutical chemical technology, and relates to a pharmaceutical composition for treating burns and scalds by taking natural medicines as effective medicinal components and a preparation method of the medicine.
Background
Burn and scald are caused by skin and muscle injury caused by external factors such as high temperature, radiation, strong light and the like, once the skin is damaged, the disease is rapidly attacked, if the skin cannot be treated in time, the mild people have erythema and water bubbles with different sizes, and the severe people have symptoms such as rot and suppuration.
The existing medicines for treating burns or scalds and the method thereof are mainly divided into the following categories: one kind is western medicine-based therapeutic medicine and therapeutic measures; one is a treatment route mainly based on traditional Chinese medicines; furthermore, the Chinese and western medicines are combined. The western medicine for treating burn is to treat the necrotic muscle tissue of the wound after cleaning and disinfecting the burn surface, then to wrap the wound, and the wound is mainly treated by internal medicines without any medicines. This approach appears scientific, does not actually slow down the pain of the patient very quickly, and is extremely expensive. One is the traditional Chinese medicine treatment route in China, namely on the basis of the theory of traditional Chinese medicine, the Chinese medicine has own knowledge and treatment measures for treating burn, and comprises folk compositions and the like. The formula of the invention is obtained by comprehensive development and research of folk proved formulas, and no external burn and scald medicine compatible with the same traditional Chinese medicinal materials is available at present through patent retrieval.
Disclosure of Invention
The invention aims to solve the technical problem of providing a pharmaceutical composition for treating burns and scalds, which has the effects of diminishing swelling, promoting tissue regeneration, astringing dampness, healing sore, promoting tissue regeneration, healing wound, resisting bacteria, diminishing inflammation, protecting wound surfaces, preventing infection and promoting wound healing.
The invention also provides a preparation method of the medicine for treating the burns and scalds, and the medicine prepared by the method has the effects of detumescence, tissue regeneration promotion, dampness astringing, sore healing, tissue regeneration promotion, wound healing, antibiosis, inflammation diminishing, wound surface protection, infection prevention and wound rapid healing.
The technical scheme for solving the technical problem is as follows:
the invention relates to a pharmaceutical composition for treating burns and scalds, which consists of common hydrangea rhizome and platycarya strobilacea, and is characterized in that the pharmaceutical composition comprises the following components in parts by weight: the weight ratio of the tamarisk is 1-3, and the weight ratio of the tamarind tree is 1-4.
The preparation method of the medicine for treating burns and scalds of the invention is as follows: taking the two medicinal materials of the common spiraea herb and the platycarya strobilacea as raw materials, mixing the two medicinal materials of the common spiraea herb and the platycarya strobilacea, adding water for extraction, filtering an extracting solution, concentrating a filtrate into an extract, and cooling to room temperature to obtain the medicine for treating the burn and the scald.
The preparation method of the invention is characterized in that the water is added for extraction for 1-3 times, wherein the weight of the added medicinal material is 6-18 times of that of the medicinal material.
The concentration of the filtrate into the extract in the preparation method of the invention is to concentrate the filtrate into the extract with the relative density of 1.05-1.3.
The medicament for treating the burns and scalds is in the dosage form of gel, paste, spray or aerosol.
The preparation method of said gel preparation is that proper quantity of carbomer is taken to make it fully swell, then added into the extracts of two medicinal materials of tassella root and platycarya strobilacea, and stirred at the same time, and stirred to uniform, then proper quantity of triethanolamine is used to regulate pH value to 5.5-6.5; adding distilled water to obtain gel.
The invention has the beneficial effects that:
the medicine composition is a clinical proved prescription, and has the effects of diminishing swelling, promoting tissue regeneration, astringing dampness, healing sore, promoting tissue regeneration, healing wound, resisting bacteria, diminishing inflammation, protecting wound surfaces, preventing infection and promoting wound healing. The external medicine fully stimulates the regeneration capability of human cells to promote the muscle tissue to grow again quickly, thereby achieving the treatment effect of short-term recovery. The application method is simple, the surface of the wound of the patient is not treated, the medicine is applied immediately, the pain is relieved or eliminated in a short time. The external medicine has more direct effect, simple dressing change and less pain, is beneficial to observing the change of the wound surface, effectively retains moisture of a medicine film formed on the wound surface by the medicine, keeps the wound surface moist, does not leave scars after healing, has no hormone and has no toxic or side effect. Can be used for treating burn, scald, ultraviolet radiation injury, and electric injury due to toxic heat.
The selected medicinal raw materials have the following functions:
the lignum Aquilariae Resinatum (Platycarya Strobiliaceae) has effects of clearing away heat and toxic materials, promoting blood circulation, removing blood stasis, relieving swelling, promoting pus discharge, inducing resuscitation, and relieving pain.
Herba Damnacanthi (Hydrangea xanthoneura Diels) has effects of clearing away heat and toxic materials, promoting blood circulation, removing blood stasis, and treating innominate toxic swelling and malignant boil.
In order to illustrate the influence of the pharmaceutical composition for treating burns and scalds of the invention on deep third-degree scalds of rats, the applicant performs the following experiments:
1 experimental method:
rats were anesthetized with ether and depilated on the back with 8% sodium sulfide, approximately 36cm depilatory area2(6 cm × 6 cm), fixing the rat on a board with holes (5 cm × 5cm square holes) in a supine position to expose the unhaired skin in the holes of the board, placing the board on an electric heating constant-temperature (90 ℃) water bath kettle for 18 seconds to form a 3-degree-deep scald model with an area of about 10% of the total surface area, and injecting the abdominal cavity immediately after scald5ml of sterile physiological saline. The scald parts are washed by cold water for 10 seconds, grouped and administrated, and the patients are fed in a single cage and eat freely.
Rats were randomly divided into 5 groups: the vehicle was administered to the high dose group (4 g/kg), the medium dose group (2 g/kg), the low dose group (1/kg), the positive control group (Meibao, 5 g/kg), and the model control group. Each group had 8 animals, and were fed freely.
The medicine composition for treating burns and scalds is prepared by the following steps: the dosage of pharmacodynamic experiment applied to the injured part is designed as follows: the high dose was 4g/kg (0.8 g/200g,2 times/day), the medium dose was 2g/kg (0.4 g/200g,2 times/day), and the low dose was 1g/kg (0.2 g/200g,2 times/day).
Influence of medicinal composition for treating burn and scald on healing area of deep third degree scald rat (n = 8)
Note: comparison with model group <0.05 ≦ 0.1
2, the influence of the medicinal composition for burns and scalds on the weight change of rats with deep third degree scalds: compared with the model group, the weight change of the rats with burns and scalds in the large dose group (4 g/kg) and the medium dose group (2 g/kg) of the pharmaceutical composition for burns and scalds is increased to different degrees, and the large dose group has obvious difference (p is less than 0.05) shown in the second table
Influence of the pharmaceutical composition for treating superficial second burn and scald on weight change of deep third degree scald rats (n = 8)
Note: comparison with model group <0.05 ≦ 0.1
3. Effects on pathological tissues: compared with the model group, the large dose group (4 g/kg) of the medicinal composition for the burns and scalds can obviously reduce the infiltration of the granulocytes (p is less than 0.05); the pathological scores (P <0.01 or P < 0.05) of the epidermal structure, collagen fiber and granulocyte infiltration can be obviously reduced by a large dose group (4 g/kg), a medium dose group (2 g/kg), a small dose group (1/kg) and a Meibao (5 g/kg) dose group of the medicinal composition for the burns and the scalds. And (4) prompting: the medicinal composition for treating the burns and the scalds has a certain repairing effect on the wound surfaces of rats with deep 3-degree scalds. See table three
Effect of pharmaceutical composition for treating skin burn and scald of exterior three on pathological histological score of skin scald of rat (n = 8)
Note: comparison with model control group < 0.05: < 0.01%
And (4) conclusion:
experimental research shows that: the large-dose group (4 g/kg), the medium-dose group (2 g/kg) and the small-dose group (1/kg) of the medicinal composition for the burns and scalds have an obvious effect of improving the wound healing rate of rats with deep 3-degree scalds, the large-dose group and the medium-dose group for the burns and scalds have an obvious effect of improving the weight reduction of the rats with the scalds, and the large-dose group (4 g/kg), the medium-dose group (2 g/kg) and the small-dose group (1/kg) of the medicinal composition for the burns and scalds can obviously reduce the epidermal structures of scald parts, collagen fibers and inflammatory cells and have a certain repairing effect on the wounds of the rats.
The applicant develops a pharmaceutical composition for treating burns and scalds, which is composed of (a first formula: composed of common spiraea herb, coriaria sinica and platycarya strobilacea), before the application of the invention, and the invention provides a new technical scheme for simplifying the formula and improving the curative effect on the basis of the pharmaceutical composition, the applicant performs comparative research on the pharmacodynamics of two medicines (a second formula: composed of common spiraea herb and platycarya strobilacea), and the research method and the effect are as follows:
1. the method comprises the following steps: placing the wood plate on an electric heating constant-temperature water bath kettle (90 ℃), fixing the rats on the wood plate with holes in a supine position, scalding for 15 seconds to form a deep 3-degree scald model, after scalding, grouping the rats, breeding the rats in a single cage, coating the medicine on the scald parts, and continuously administering the medicine twice a day for 28 days. Weighing and photographing on days 1, 7, 14, 21 and 28 after scald, analyzing and measuring scald area by using a medical image analysis system, determining the area healing rate of the medicament on the scald wound surface, and analyzing the influence of the medicament on the histopathology.
2. The effect is as follows: research results show that compared with a model group, the burn and scald ointment prepared by the medicine composition has the advantages that the wound healing rate is obviously increased after the burn and scald ointment is applied for 7 days; compared with the first formula (comprising radix Aconiti Kusnezoffii, herba Coriandri, and HUAXIANGSHU), the second formula (comprising radix Aconiti Kusnezoffii and HUAXIANGSHU) has obvious effect. The ointment has good protection effect on a rat deep 3-degree scald model, and can obviously promote wound healing.
Comparison of burn and scald area healing rates of the first and second compositions (n = 8)
Note that the comparison of formula one and formula two (▲ represents p < 0.05)
The table shows that: compared with the first formula, the second large-dose formula has significant difference, and the second small-dose formula has significant difference, which shows that the effect of the second large-dose group is better than that of the first large-dose group, and the effect of the second small-dose group is better than that of the first small-dose group.
The research result shows that the burn and scald ointment can obviously promote the healing of the scald wound of the rat, improve the pathological and histological changes of the wound and has good protection and repair effects on a rat deep 3-degree scald model.
The research results show that compared with the prior art, the invention has the advantages of easy implementation of the technology, obvious treatment effect and improved cure rate.
Detailed Description
Example 1
Pulverizing 4kg of radix hydrangeae strigosae and 1kg of platycarya strobilacea, mixing, adding 6 times of water for extracting for 3 times, combining filtrates, concentrating to obtain an extract with a relative density of 1.05, and cooling to room temperature for later use; taking a proper amount of carbomer to fully swell the carbomer; adding into the above fluid extract, stirring, adding appropriate amount of triethanolamine, and adjusting pH to 6.5; adding distilled water, stirring, packaging, and sterilizing to obtain gel preparation for treating burn and scald.
Example 2
Pulverizing and mixing 3kg of radix hydrangeae strigosae and 1kg of platycarya strobilacea, adding 18 times of water for 2 times, combining filtrates, concentrating to obtain an extract with a relative density of 1.25, and cooling to room temperature to obtain the medicine for treating burn and scald. The pharmaceutical composition is in the form of gel, paste, spray or aerosol.
Example 3
Pulverizing and mixing 4kg of radix hydrangeae strigosae and 3kg of platycarya strobilacea, adding 12 times of water for extracting for 1 time, combining filtrates, concentrating to obtain an extract with a relative density of 1.4, and cooling to room temperature to obtain the medicine for treating burn and scald. The pharmaceutical composition is in the form of gel, paste, spray or aerosol.
Example 4
Pulverizing 1kg of radix Aconiti Kusnezoffii and 1kg of lignum Aquilariae Resinatum, mixing, extracting with 8 times of water for 1 time, mixing filtrates, concentrating to obtain extract with relative density of 1.0, and cooling to room temperature to obtain the medicine for treating burn and scald. The pharmaceutical composition is in the form of gel, paste, spray or aerosol.
The medicinal composition for treating the burns and the scalds has obvious tendency of promoting wound healing after the burns and the scalds, and has obvious inhibiting effect on deep third-degree and deep second-degree burns and scalds. Can obviously reduce the surface skin structure, collagen fiber and inflammatory cell of the burn and scald part, has certain repairing function on the wound surface, and has obvious analgesic effect. The use method comprises the following steps: the composition is applied topically, twice a day, and applied to affected parts.
Claims (6)
1. A pharmaceutical composition for treating burns and scalds, which consists of hydrangea macrophylla and platycarya strobilacea, and is characterized in that: the composition comprises the following components in parts by weight: 1-3 parts of white spiraea herb suspension and 1-4 parts of platycarya strobilacea.
2. The pharmaceutical composition for treating burns and scalds according to claim 1, which is characterized in that: the preparation method of the pharmaceutical composition takes two medicinal materials of common hydrangea rhizome and platycarya strobilacea as raw materials, and comprises the following steps by weight: 1-3 parts of common spiraea herb and 1-4 parts of platycarya strobilacea, and the medicine for treating the burn and the scald is prepared by mixing the two medicinal materials of the common spiraea herb and the platycarya strobilacea, adding water for extraction, filtering the extracting solution, concentrating the filtrate into extract and cooling the extract to room temperature.
3. The pharmaceutical composition for treating burns and scalds according to claim 2, which is characterized in that: the method for extracting by adding water is to extract the medicinal materials for 1 to 3 times by adding water which is 6 to 18 times of the weight of the medicinal materials.
4. The pharmaceutical composition for treating burns and scalds according to claim 2, which is characterized in that: the concentration of the filtrate into the extract is to concentrate the filtrate into the extract with the relative density of 1.05-1.3.
5. The pharmaceutical composition for treating burns and scalds according to claim 2, which is characterized in that: the prepared medicinal preparation is gel, paste, spray or aerosol.
6. The pharmaceutical composition for treating burns and scalds according to claim 5, which is characterized in that: the preparation method of the gel comprises the steps of taking a proper amount of carbomer, fully swelling the carbomer, adding the carbomer into the extractum of the two medicinal materials of the common hydrangea root and the platycarya strobilacea, stirring while adding the mixture until the mixture is uniform, and then adjusting the pH value to be 5.5-6.5 by using a proper amount of triethanolamine; adding distilled water to obtain gel.
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Non-Patent Citations (2)
| Title |
|---|
| 化香属药学研究概况;杨文慧等;《安徽农业科学》;20111231;第39卷(第31期);第19084-19085,19092页 * |
| 化香树果糖浆的制备与临床应用;张小勇等;《中国医院药学杂志》;19991231;第19卷(第7期);第437-438页 * |
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Effective date of registration: 20230322 Address after: 725000 No. 6 Pioneering East Road, Ankang High-tech Industrial Development Zone, Shaanxi Province Patentee after: Ankang Innovation Institute of Chinese Pharmaceutical Research Co.,Ltd. Address before: No. 2, Chuangye East Road, Ankang Hi-tech Industrial Development Zone, Ankang City, Shaanxi Province, 725000 Patentee before: ANKANG PHARMACEUTICAL INSTITUTE OF PEKING University |
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Denomination of invention: A combination of drugs for treating burns and scalds and a method for preparing the drugs Granted publication date: 20200324 Pledgee: Industrial Bank Limited by Share Ltd. Xi'an branch Pledgor: Ankang Innovation Institute of Chinese Pharmaceutical Research Co.,Ltd. Registration number: Y2024980031494 |