CN101468140A - Gel patch for treating cardiopalmus and method for preparing the same - Google Patents
Gel patch for treating cardiopalmus and method for preparing the same Download PDFInfo
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- CN101468140A CN101468140A CNA2007100604834A CN200710060483A CN101468140A CN 101468140 A CN101468140 A CN 101468140A CN A2007100604834 A CNA2007100604834 A CN A2007100604834A CN 200710060483 A CN200710060483 A CN 200710060483A CN 101468140 A CN101468140 A CN 101468140A
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Abstract
The present invention relates to a gel plaster for palpitation and its preparation mehtod thereof, composed of 5% -50% of extract of traditional Chinese medicine and 95% -50% of medicinal adjuvant. The traditional Chinese medicine plaster capable of treating palpitation is prepared by mixing the molecule gel, the hydrogel, active ingredients of medicine extracts with the plural gel factor. Different medicine extracts enter into the skin through different channels. The oil-soluble component in molecule gel has repulsion force to the water-soluble medicine and the water-soluble component in hydrogel has repulsion force to the oil-soluble medicine therefore the medicine absorption is promoted and the medicine efficacy is increased.
Description
Technical field
The present invention relates to the up-to-date molecular gel of Percutaneously administrable preparation technical field and combine with hydrogel and make profit ampholytic gels patch, the Chinese medicine extract that adopts the Chinese medicine prescription is basis profit ampholytic gels patch with the effect of treatment cardiopalmus and preparation method thereof of medicinal substrate preparation in addition.
Background technology
Transdermal drug delivery system or percutaneous absorption patch refer to stick the mode medication through skin, and medicine enters the systemic blood circulation by skin absorbs and reaches a class preparation of effective blood drug concentration, realization disease treatment or prevention.The characteristics of percutaneous absorption patch are, transdermal drug delivery system can avoid the first pass effect of liver and medicine in the gastrointestinal deactivation, the absorption of medicine is not subjected to the influence of gastrointestinal factors, reduce the individual variation of medication, keep constant effective blood drug concentration or physiological effect, the blood drug level peak valley phenomenon of avoiding oral administration to cause reduces toxicity.Reduce administration number of times, improve therapeutic efficacy, prolong action time, avoid multiple dose administration, make most patient be easy to accept, simultaneously easy to use, independently medication of patient also can be cancelled medication at any time.
So-called profit ampholytic gels is not the zwitterion that we say usually, because molecular gel generally all is as solvent by oil-based solvent, organic solvent or the mixture of the two, it is gel with oleophilic properties, and used aqueous solvent accounts for greatly in the hydrogel, it is the gel of possess hydrophilic property matter, the two is used, so be called the profit ampholytic gels.
Molecular gel is that the gel factor (some micromolecule organic compound) is passed through non-covalent interaction in non-aqueous media, spontaneously assembles, assembles orderly three-dimensional fiber network structure, makes the medium gelation.Molecular gel has reversible characteristics of heat, and processing technology is simple, and gelinite contains a large amount of organic solvents, be fit to the storage storehouse as lipophilic medicament, but molecular gel exists cohesiveness low, and viscosity is little, with the skin poor compliance, is not suitable for making shortcomings such as patch.Hydrogel water content height is fit to the storage storehouse as hydrophilic medicament, and is strong to the skin compliance, but is subjected to the influence of self property, and colloid poor plasticity, elasticity are little.In sum, be advantage in conjunction with these two kinds of gels, adopt the pluralgel factor that two kinds of gelinites are disperseed mixing, with the molecular gel is framework material, the patch substrate that hydrogel is made as sticky stuff, both high resilience forms have good compliance with skin, can peel off repeatedly, paste again, improve the drug loading of hydrophilic medicament and hydrophobic drug simultaneously again.Two kinds of gels twine staggered uniform distribution in substrate, by non-covalent bond form combinations such as Van der Waals forces, by fully contacting with skin, the both sexes medicine continues to see through skin through passage separately, enters blood circulation, the performance drug effect.
Cardiopalmus is conscious rapid heart beat and strong, and with the pareordia sense of discomfort.The category that belongs to motherland's medical science " palpitation with fear " and " severe palpitation ".The reason that causes cardiopalmus is a lot, visible substantially following a few class diseases:
1. cardiovascular disease is common in various types of heart diseases, as myocarditis, cardiomyopathy, pericarditis, arrhythmia and hypertension etc.
2. non-cardiovascular disease is common in diseases such as anemia, hypoglycemia, massive blood loss, hyperpyrexia, hyperthyroidism and hydrothorax, pneumothorax, pneumonia, pulmonary atelectasis, ascites, intestinal obstruction, intestinal tympanites etc.; Be also shown in the cardiopalmus that occurs behind the medicines such as epinephrine, isoproterenol, aminophylline, atropine in using.
3. neural factor autonomic nerve (vegetative nerve) dysfunction is the most common, neurasthenia, climacteric syndrome, terrified or be overexcited, all cardiopalmus can occur after the strenuous exercise.
Since cardiopalmus have morbidity anxious, change fast, can repeatedly fall ill disable, characteristics such as sudden death rate height, social labor power and patient's quality of life in serious harm, thereby it is that medical circle is concentrated the heat subject of paying close attention to and being devoted to research and solve always for a long time.More existing pharmaceutical preparatioies still can not be satisfied clinical and needs market fully, still await the personnel of research institution and do further exploration to develop even more ideal new Chinese medicine.
At present, the drug main that is used for the treatment of cardiopalmus will have that heart rate is flat, Folium Digitalis Purpureae, phenytoin Sodium, lignocaine, atlansil, dilantin etc., though all have certain curative effect, but in the clinical practice also corresponding also exist with otherwise comprehensively, problem such as curative effect is unstable and cure rate is low, some medicine also can produce some untoward reaction even toxic side effect to human body.
The objective of the invention is to problem at the above existence, by excavate motherland's Chinese medicine resource provide a kind of prescription science, preparation and easy to use, curative effect is high and human body is had no adverse reaction and the profit ampholytic gels patch that is used for the treatment of cardiopalmus of toxic and side effects.
Summary of the invention
The present invention is in conjunction with the advantage of up-to-date molecular gel and hydrogel, on a large amount of research bases, invented the more effective pure Chinese prescription preparation of a kind of treatment cardiopalmus, and be prepared as profit ampholytic gels patch, being convenient to the patient and carrying and use, is a kind of treatment cardiopalmus to be had Transdermal absorption profit ampholytic gels patch of positive effect and preparation method thereof.
Radix Salviae Miltiorrhizae has promoting blood flow to regulate menstruation among the we, the removing heat from blood eliminating carbuncle, and effect such as calm the nerves can QI invigorating and blood producing; Nourishing YIN and clearing away lung-heat is arranged Radix Ophiopogonis, reinforcing stomach reg fluid, the relieving restlessness effect clears away heart-fire; The Fructus Schisandrae Chinensis YIN nourishing of astringing the lung, the arresting sweating that promotes the production of body fluid, the effect of arresting seminal emission antidiarrheal, mind tranquilizing and the heart calming; The Radix Astragali has tonifying Qi and lifting yang, and benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, the effect of holder skin ulcer granulation promoting.All medicines are harmonious, and by invigorating heart and kidney, yin nourishing clears away heart-fire, blood-cooling and spirit-quieting, and invigorating the spleen and replenishing QI reaches the effect of treatment cardiopalmus.Be made into profit ampholytic gels patch, have evident in efficacy, steady slow the continuing of release.Used gel coherence is better, and the glue sample is flexible, and viscosity fastness is better, can peel off multiple subsides repeatedly; Water content is big, and is strong with the skin compliance, helps the Transdermal absorption of medicine; Preparation process is simple, convenient.
The technical solution used in the present invention is: a kind of Chinese medicine composition profit ampholytic gels patch for the treatment of cardiopalmus and preparation method thereof; it is made up of backing layer, adhesive-layer, protective layer, it is characterized in that the adhesive-layer in this patch mainly is made up of medicine, profit ampholytic gels and short penetrating agent.Said preparation is made up of following medicaments in part by weight extract, wherein, Radix Salviae Miltiorrhizae 5-25, Radix Ophiopogonis 5-25, Fructus Schisandrae Chinensis 2-20, Radix Astragali 20-60.The weight part ratio of adhesive-layer Chinese medicine effective ingredient and profit ampholytic gels (molecular gel: hydrogel is 1:1-10) is 1:1-15.Transdermal enhancer 3-8 weight portions, the weight percent content of the effective ingredient of Chinese medicine mixture is 5%-50% in the gel adhesive.Transdermal penetration agent, effective ingredient extract, molecular gel and hydrogel add with order respectively in proportion, and mix homogeneously is uniformly coated on the backing layer, the compound protective layer of going up, and after the extrusion modling, sterilization, stamping-out are made product.
Described drug molecule gel can be made as follows: 1%-30% gel factor is dissolved in the mixture of specific organic solvent or organic solvent.Medicine is dissolved in the organic solvent, adds a certain amount of gel factor then and mix, promptly get molecular gel.The gel factor that is adopted is divided into two classes, the first kind is simple tertiary amine and quaternary ammonium salt thereof such as lecithin, N, N, the two octadecane amine of N-three-octadecane amine, gallbladder steroid eicosane amine, methyl, dioctadecyl dimethyl ammonium chloride and cyclodextrin derivative class as: organic molecules such as beta-schardinger dextrin-, second class are derivative of fatty acid as 12-hydroxy octadecadienoic acid and associated salts thereof, glyceryl monostearate, glyceryl tristearate, tripalmitin etc.Organic solvent comprises alkanes, arene, dimethyl sulfoxide (DMSO), acetonitrile, 1-propanol, 1-amylalcohol, 1-capryl alcohol, propylene glycol, glycerol, silicone oil, 14/isopropyl palmitate etc.
Described medicine hydrogel can be made as follows:
The first kind, 2%-15% sodium polyacrylate, 1%-30%PVP and 1%-20%CMC-NA pressed powder mix homogeneously are scattered in 15%-60% propylene glycol, the glycerol solvent, and mix homogeneously adds 40%-80% deionized water mix homogeneously promptly.The 0%-15% additive, additive comprises: Kaolin, starch, micropowder silica gel, aluminum chloride, Alumen, sodium alginate etc.
Second class, 0.1%-10% carbomer, 1%-20% sodium polyacrylate, 15%-40% glycerol, 30%-80% propylene glycol, 3%-15% ethanol, 5%-20% additive, additive comprises: Kaolin, starch, micropowder silica gel, citric acid, citric acid, ethanol, aluminum chloride, triethanolamine, ethyl hydroxybenzoate, ammonium stearate, disodium EDTA (EDTA-2Na), sodium benzoate, parabens or the like.
The above-mentioned described first kind prescription gel factor can only cooperate with first kind gel, and the second gellike factor and the second gellike agent cooperate.Because the fundamental property of two gellikes is different, intersection is combined with change or the chemical reaction that framework may take place.
Penetrating agent of the present invention comprises dimethyl sulfoxide and analog: dimethyl sulfoxide (DMSO); Azone compounds: laurocapram Azone; Alcohol compound: ethanol, propylene glycol, glycerol; Volatile oil and or their mixture etc.Described backing layer is non-woven fabrics or polyester film, and protective layer is paper or polyester film through release treatment.
Chinese crude drug extraction process of the present invention is not limited to aqueous extraction-alcohol precipitation technology, also can be that water is put forward other extraction processes such as organic solvent extractionprocess, alcohol extraction organic solvent extractionprocess and supercritical fluid extraction; Coating processes such as the also available blade coating molding of the preparation technology of patch.Gel adhesive of the present invention can be made arbitrary shape.
Process conditions:
A. extract drugs technology
(a) get a certain amount of salviamiltiorrhizabung, use 50-100% alcohol reflux 2-5 time, use 6 times of water gagings respectively, decoct 60-150min, filter merging filtrate, the distilled water that adds doubling dose is placed 1-5h, makes precipitation fully, decompression, the collecting precipitation thing, drying, so triplicate, merge precipitate, standby.
(b) get a certain amount of Fructus Schisandrae Chinensis,, with 8 times of amount ethanol, extract 2h for the first time, measure ethanol with 6 times for the second time with 70% alcohol reflux 2 times, reflux, extract, 1.5h, filtration, merging filtrate, concentrating under reduced pressure is to certain volume extractum, and is standby.
(c) get a certain amount of Chinese medicine astragalus, with 50-100% alcohol reflux three times, the alcohol extraction 60min that doubly measures with 3-8 respectively, merging filtrate reclaims solvent, is concentrated into the extractum state, and is standby.
(d) get a certain amount of Chinese medicine Radix Ophiopogonis, pulverize, add the ethanol of the 50%-100% that 3-10 doubly measures, reflux, extract, three times, the time is 45-150min, filter, filtrate, decompression and solvent recovery is concentrated into 30-300ml, and is standby.
B. the preparation technology of patch:
(a) preparing process of profit ampholytic gels:
The first kind: get a certain amount of sodium polyacrylate, PVP and CMC-NA pressed powder and add in the agitator, heat 20-90 ℃, be scattered in propylene glycol, the glycerol solvent, mix homogeneously, after adding molecular gel required organic solvent and drug extract mixing behind the adding deionized water mix homogeneously, after slowly mixing after the adding mixed gel factor, progressively lower the temperature, form the profit ampholytic gels until room temperature.
Second class: get in a certain amount of carbomer, sodium polyacrylate, glycerol, propylene glycol, ethanol, the additive adding agitator, heat 20-90 ℃, behind the mix homogeneously, add required organic solvent and the drug extract mixing of molecular gel, after slowly mixing after the adding mixed gel factor, progressively lower the temperature until room temperature, form the profit ampholytic gels.
(b) preparation technology of paster
The drug matrices that is mixed is evenly coated on the backing layer non-woven fabrics, will covers on the medicine glue-line through the polyester protecting film that release treatment is crossed, enter the roller bearing extrusion modling, THICKNESS CONTROL is below 5mm.Stamping-out, screening, quality inspection, packing are carried out by specification in the sterilization back.
(c) profit ampholytic gels patch application characteristic:
Respectively to hydrogel adhesive, oil-base gel agent, molecular gel agent, four kinds of gels of ampholytic gels patch from mouldability, first viscous force, peeling force, tough elastic force, seven performance indications of compliance of skin irritation, preparation stability, patient are investigated.Every definition standard is as follows.
Mouldability: four kinds of gels of equal in quality are coated on the non-woven fabrics uniformly the overall appearance of observing colloid, loosely organized degree.
First viscous force: the assay method according to the first viscous force of patch in (2005) second appendix XJ patches of Chinese Pharmacopoeia adhesive force algoscopy is measured comparison to four kinds of gels that are coated on the non-woven fabrics.
Peeling force: the assay method according to peel strength in (2005) second appendix XJ patches of Chinese Pharmacopoeia adhesive force algoscopy is measured comparison to four kinds of gels that are coated on the non-woven fabrics.
Tough elasticity: coating on the non-woven fabrics circular glass sheet of placing identical size on four kinds of gel-type vehicles, a 20g counterweight is put by sheet central authorities, after the pressure relief, observes gel shape recovery situation and compares.
Skin irritation: observe animal intact skin single and repeatedly contact gel the local excitation reaction that is produced.(300g ± 20g), male and female half and half are divided into 8 groups, 5-6 every group to choose healthy albino guinea-pig.24h is with Cavia porcellus spinal column both sides unhairing before administration, check whether skin of unhairing has wound, apply ointment or plaster in the left and right sides of every Cavia porcellus the respectively gel of same dose is observed single-dose and is removed the situation that erythema and edema appear in skin in 1h, 24h behind the gel, 48h, the 72h.Repeatedly apply ointment or plaster more than the week, observe again a week after stopping, the redness of observed and recorded skin every day and edema situation and smear the position whether pigmentation, situation such as hemorrhage are arranged.Stability: placed at ambient temperature 1 month, the character of observing each gel changes situation.
Patient's compliance: select some normal adults, stick four kinds of gels respectively, compare from situations such as the sensation of skin, degree easy to use.
Four kinds of various performance comparison results of gel
Annotate: +++for well; ++ in; + for poor
The specific embodiment
Below example by the specific embodiment, foregoing of the present invention is described in further detail, embodiment only is indicative, means that never it limits the scope of the invention by any way.But do not breaking away under the above-mentioned technological thought situation of the present invention, the various replacements of making according to ordinary skill knowledge and habitual means or the modification of change include within the scope of the invention.
Embodiment 1:
Transdermal enhancer laurocapram Azone 3.5kg
Molecular gel 2.5% lecithin,
97.5% Semen Myristicae isopropyl ester 100kg
Hydrogel 8% sodium polyacrylate, 2% polyvinylpyrrolidone
2% sodium carboxymethyl cellulose, 20% propylene glycol
20% glycerol, 48% deionized water 400kg
Effective ingredient extract 75kg
Take by weighing 32kg sodium polyacrylate, 8kg polyvinylpyrrolidone and 8kg sodium carboxymethyl cellulose pressed powder mix homogeneously, be scattered in 80kg propylene glycol, the 80kg glycerol solvent, mix homogeneously in agitator adds the 192L deionized water, mix homogeneously, get 97.5kg Semen Myristicae isopropyl ester and place agitator, add 75Kg effective ingredient mixture, contain Radix Salviae Miltiorrhizae 15kg in the mixture, Fructus Schisandrae Chinensis 15kg, Radix Astragali 15kg, Radix Ophiopogonis 15kg.Add the 3.5Kg laurocapram, 60 ℃ of heated and stirred add 2.5Kg lecithin to mixings fully, after slowly stirring with 100 rev/mins, cooling, temperature reduce to stop to stir after the room temperature leave standstill 5h gel.The drug gel substrate that is mixed is evenly sprayed cloth on the backing layer non-woven fabrics, will cover on the medicine glue-line through the polyester protecting film that release treatment is crossed, enter the roller bearing extrusion modling, THICKNESS CONTROL is below 5mm.Stamping-out is carried out by specification in the sterilization back, makes patch, and coefficient of losses 15% is pressed Chinese Pharmacopoeia patch standard through quality inspection qualification rate 85%.The certified products packing.
Embodiment 2:
Transdermal enhancer oleic acid 3.5kg
Molecular gel 5% glyceryl monostearate
95% cyclohexane extraction 150kg
Hydrogel 0.5% carbomer, 5% sodium polyacrylate
28.5% propylene glycol, 60% glycerol,
4% ethanol, 1.4% Kaolin,
0.2% citric acid, 0.4% triethanolamine 500kg
Effective ingredient extract 100kg
Take by weighing the 25kg sodium polyacrylate, 2.5kg carbomer pressed powder mix homogeneously, be scattered in the 142.5kg propylene glycol, in the 300kg glycerol solvent, mix homogeneously in agitator, add 20Kg ethanol, 7Kg Kaolin, the 1Kg citric acid, the 2Kg triethanolamine, mix homogeneously, get the 142.5kg cyclohexane extraction and place agitator, add 100Kg effective ingredient mixture, containing the Radix Salviae Miltiorrhizae extract weight portion in the mixture is 20kg, Fructus Schisandrae Chinensis 20kg, Radix Astragali 35kg, Radix Ophiopogonis 20kg, add 3.5Kg oleic acid, 60 ℃ of heated and stirred add the 7.5Kg glyceryl monostearate, after slowly stirring with 100 rev/mins to complete mixing, cooling, temperature reduce to stop after the room temperature stirring leave standstill 5h gel.The drug matrices that is mixed is evenly sprayed cloth on the backing layer non-woven fabrics, will cover on the medicine glue-line through the polyester protecting film that release treatment is crossed, enter the roller bearing extrusion modling, THICKNESS CONTROL is below 5mm.Stamping-out is carried out by specification in the sterilization back, makes patch, and coefficient of losses 5% is pressed Chinese Pharmacopoeia patch standard through quality inspection qualification rate 95%.The certified products packing.
Claims (7)
1. treat gel adhesive of cardiopalmus and preparation method thereof for one kind; it is characterized in that: it is made up of backing layer, adhesive-layer, protective layer; adhesive-layer is by Radix Salviae Miltiorrhizae 5; Radix Ophiopogonis, Fructus Schisandrae Chinensis, extract and molecular gel, hydrogel, the transdermal enhancer of the Radix Astragali four flavor Effective Components of Chinese Herb are mixed and made into; the weight portion proportioning is: effective ingredient extract 10-200 part; 3-8 parts of transdermal enhancers, 100-300 parts of molecular gels, 200-1000 parts of hydrogels.
2. according to described a kind of gel adhesive for the treatment of cardiopalmus of claim 1 and preparation method thereof, it is characterized in that: described molecular gel is formed and percentage by weight is: the gel factor 1%-30%, solvent or their mixture 50%-90%.The gel factor comprises the tertiary amine of ad hoc structure and quaternary amines organic compound thereof such as lecithin, N, N, N-three-octadecane amine, gallbladder steroid eicosane amine, the two octadecane amine of methyl, dioctadecyl dimethyl ammonium chloride; Organic molecules such as cyclodextrin derivative class such as beta-schardinger dextrin-; Derivative of fatty acid such as 12-hydroxy octadecadienoic acid and associated salts thereof, glyceryl monostearate, glyceryl tristearate, tripalmitin etc.Solvent comprises alkanes, arene, dimethyl sulfoxide (DMSO), acetonitrile, 2-ethoxy ethanol, 1-propanol, 1-amylalcohol, 1-capryl alcohol, 1,2-propylene glycol, glycerol, silicone oil, 14/isopropyl palmitate etc.
3. according to described a kind of gel adhesive for the treatment of cardiopalmus of claim 1 and preparation method thereof, it is characterized in that: the composition of described hydrogel and percentage by weight are water-soluble base, water-insoluble substrate or their mixture 5%-30%, solvent 50%-90%, additive 1%-10%.Water-soluble base and non-aqueous substrate comprise polypropylene acid, sodium polyacrylate, carbomer resin, polyvinylpyrrolidone, sodium carboxymethyl cellulose, methylcellulose, polyvinyl alcohol and/or their mixture of various models; Additive comprises Kaolin, starch, micropowder silica gel, aluminum chloride, Alumen, sodium alginate etc.; Solvent comprises deionized water, propylene glycol, glycerol, ethanol and/or their mixture.
4. according to described a kind of gel adhesive for the treatment of cardiopalmus of claim 1 and preparation method thereof, it is characterized in that: described penetrating agent comprises dimethyl sulfoxide and analog, azone class, alcohol compound, volatile oil and/or their mixture.
5. according to described a kind of gel adhesive for the treatment of cardiopalmus of claim 1 and preparation method thereof, it is characterized in that: described backing layer is non-woven fabrics or polyester film, and protective layer is paper or polyester film through release treatment.
6. according to described a kind of gel adhesive for the treatment of cardiopalmus of claim 1 and preparation method thereof, it is characterized in that: described preparation process comprises:
Getting the required organic solvent of the required mixture of a certain amount of preparation hydrogel, solvent, deionized water and preparation molecular gel adds in the agitator, heat 20-90 ℃, after mixing, add the abundant mixing of effective ingredient extract, after slowly mixing after the adding mixed gel factor, progressively lower the temperature until room temperature, form gel.
7. according to described a kind of gel adhesive for the treatment of cardiopalmus of claim 1 and preparation method thereof, it is characterized in that: preparation technology is spreading formation process, extrusion modling or spray mo(u)lding technology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100604834A CN101468140A (en) | 2007-12-28 | 2007-12-28 | Gel patch for treating cardiopalmus and method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100604834A CN101468140A (en) | 2007-12-28 | 2007-12-28 | Gel patch for treating cardiopalmus and method for preparing the same |
Publications (1)
| Publication Number | Publication Date |
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| CN101468140A true CN101468140A (en) | 2009-07-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100604834A Pending CN101468140A (en) | 2007-12-28 | 2007-12-28 | Gel patch for treating cardiopalmus and method for preparing the same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526220A (en) * | 2012-01-10 | 2012-07-04 | 上海市中医医院 | Chinese medicinal patch for treating premature systole and preparation method and application of Chinese medicinal patch |
| CN113081954A (en) * | 2021-05-25 | 2021-07-09 | 南昌大学第二附属医院 | Gel drug-loaded patch drug delivery system |
-
2007
- 2007-12-28 CN CNA2007100604834A patent/CN101468140A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526220A (en) * | 2012-01-10 | 2012-07-04 | 上海市中医医院 | Chinese medicinal patch for treating premature systole and preparation method and application of Chinese medicinal patch |
| CN113081954A (en) * | 2021-05-25 | 2021-07-09 | 南昌大学第二附属医院 | Gel drug-loaded patch drug delivery system |
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Open date: 20090701 |