CN102648922B - Gamuzhuer medicinal latex preparation and preparation method thereof - Google Patents
Gamuzhuer medicinal latex preparation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Gamuzhuer medicinal latex preparation and a preparation method thereof. The Gamuzhuer medicinal latex preparation comprises the following components by weight percentage: 10-40% of Gamuzhuer, 0.1-8% of bioadhesive agent, 0.1-5% of non-ionic emulsifier, 1-30% of glycerol, 0-30% of grease and the balance of water. The bioadhesive material is bond with the Gamuzhuer, so thatmedicines are dispersed and adhered to a focus part so as to achieve a therapeutic aim; the Gamuzhuer latex preparation has a higher content, is more convenient to administer and is not added with any irritant solvent; the acting time is prolonged; during preparation, a proper amount of emulsifier is added, so that dissolution of musk and borneol can be promoted; compared with the conventional powdery preparation, the latex preparation takes effect more quickly; a proper amount of grease and a proper amount of emulsifier are added to achieve a good lubricating effect; the grain diameter of the medicinal powder is optimized, so that 99 percent of the powder is smaller than 100 um and thus the stability of the medicinal powder is improved; and the medicines have antibacterial and antisepticfunctions, so that a preservative is not required.
Description
Technical field
The present invention relates to a kind of loud, high-pitched sound wood Zhu Er emulsion agent and preparation method thereof.
Background technology
Traditional Mongolia patent drug loud, high-pitched sound wood Zhu Er belongs to Mongolian medicine's classic prescriptions, and each clinical line is used for many years in the Inner Mongol.Loud, high-pitched sound wood Zhu Er is made up of Borneolum Syntheticum, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, Mirabilitum crystallina, Moschus 7 flavor medicines, has functions such as granulation promoting, convergence, is used for aphtha of the mouth and tongue, ulcer, pharyngitis, skin ulceration, trauma infection contamination, diseases such as cervical erosion.Loud, high-pitched sound wood Zhu Er is compound preparation, wherein has 5 compositions to record into one one of 2005 editions Chinese Pharmacopoeia, is respectively Realgar, Cinnabaris, Concha Haliotidis, Borneolum Syntheticum and Moschus, mostly is reducing swelling and alleviating pain greatly, the dysmenorrhea of invigorating blood circulation, the refreshment of having one's ideas straightened out, detoxifcation parasite killing.Vermilion is recited as in Compendium of Material Medica and cures mainly that stupid painful abdominal mass does not close up, the wet bleb of yellow fluid, flame erysipelas etc.; The medicinal herbs most in use selected works record into Mirabilitum crystallina be resolving heat and reducing pathogenic fire, the repellent of having one's ideas straightened out.Above-mentioned seven flavor medicine form conventional dosage forms---external-use ulcer powder is the externally applied anti-inflammation good recipe,, cure the wound medicine Mirabilitum crystallina xeothermic based on clear Ba Da in the side is equipped with heat-clearing and toxic substances removing, reducing swelling and alleviating pain medicine Borneolum Syntheticum is auxilliary; Realgar is held back skin ulcer to end corruption, kills sticking detumescence, and Vermilion, Cinnabaris are cured the wound with heat clearing away, and Concha Haliotidis is cured the wound with dry yellow fluid, and Moschus is sticking to kill, pain relieving; Make for assistant altogether.Each medicine share, and has possessed granulation promoting and has cured the wound, and kills sticking anti-inflammatory effect, therefore so to various ulcer, inflammation all has specially good effect.
Mongolian medicine loud, high-pitched sound wood Zhu Er merges the evident in efficacy of skin infection or trauma in treatment, to mucocutaneous ulcer, have and ooze out and rotten to the corn skin eczema and the total effective rate of viral dermatosis can reach more than 95%.In ulcerative colitis, also there is report to adopt loud, high-pitched sound wood Zhu Er treatment, total effective rate is 90.5%.Cervical erosion is commonly encountered diseases, the frequently-occurring disease of gynecological, belongs to the traditional Chinese medical science " leukorrheal diseases " category, and sickness rate accounts for about 60% of gynecological's outpatient service, with the substantial connection that has of cervical cancer.Loud, high-pitched sound wood Zhu Er treats the evident in efficacy of cervical erosion, more and more comes into one's own.(Chinese national folk medical magazine,, 4 volume supplementary issues: 17) select 25～50 years old in 1998 such as Bao Guilan, non-pregnancy, and do not accept other method therapist in 3 months, with loud, high-pitched sound wood Zhu Er treatment cervical erosion 40 examples, the next day, add medicine to, and 7～10 days is 1 course for the treatment of, and cure rate is 97.5%.He Xiaohong etc. (western medical science, 2006,18 (3): 186～187) choose be diagnosed as in the cervix uteri, patient's 100 examples that micro-wave therapeutic is carried out in the severe erosion, be divided into two groups at random, seminar gives microwave and adds loud, high-pitched sound wood Zhu Er treatment, matched group only gives micro-wave therapeutic.The result shows: seminar's 50 examples, cure 46 examples, and cure rate is 92%; Matched group 50 examples are cured 33 examples, and cure rate is 70%, two group and compares that difference has statistical significance.The cure rate height of microwave combined loud, high-pitched sound wood Zhu Er treatment cervical erosion, complication is few, and the meaning of popularization is arranged.
Loud, high-pitched sound wood Zhu Er is used for granulation promoting, convergence, cures mainly ulcer, pharyngitis, skin ulceration, trauma infection contamination, cervical erosion etc., and is evident in efficacy.But loud, high-pitched sound wood Zhu Er is in treatment, and its a plurality of components are mineral powders, sprays with powder during administration or is applied in the affected part, not only use inconvenience, and dosage is difficult to guarantee.Bibliographical information the exterior-applied gel of loud, high-pitched sound wood Zhu Er and the research of liniment, content of dispersion is about 8%, but all adopts the dissolve with ethanol Borneolum Syntheticum in preparation process, the ethanol consumption that has even reach 20%, the pain that can cause wound or ulcer spot more is not suitable for vagina administration.(Jia Haibo, preparation and the stability study of loud, high-pitched sound wood Zhu Er gel, Chinese national medicine magazine, 2003,9 (2): 41; Like the people, Jia Haibo, Jia Haiying, the zest of loud, high-pitched sound wood Zhu Er liniment is investigated Chinese national medicine magazine, 1999,5 (2): 41; Like the people, Jia Haibo, Jia Haiying, preparation and the quality control of loud, high-pitched sound wood Zhu Er liniment, Chinese national medicine magazine, 1999,5 (4): 41)
Also have research to be made into suppository and use to make things convenient for its gynecological, but owing to contain mineral and large usage quantity in the compound recipe, the molding difficulty of its suppository is big, is difficult to preparation.Chinese patent 200610112027.5 relates to a kind of mongolian medicine for the treatment of gynecological inflammation, adopts pharmaceutically active ingredient in the alcohol extraction in the preparation process, and remaining ethanol also has bigger zest; And used sodium lauryl sulphate to be emulsifying agent during preparation, the anion emulsifier zest is also bigger.
With reference to former application method and good curative effect thereof, Borneolum Syntheticum does not need to be dissolved in the ethanol equal solvent, but also onset of loud, high-pitched sound wood Zhu Er.Therefore, avoid using the adjuvant with potential stimulus to prepare novel loud, high-pitched sound wood Zhu Er, can be used for dermatosis outward, also can pour into special doser vagina administration.In addition, the composition of loud, high-pitched sound wood Zhu Er contains several mineral materials, and its density is bigger, and in common Emulsion or gel, oarse-grained powder causes medicine inhomogeneous sedimentation gradually, therefore, the particle diameter of drug powder is controlled, and will be beneficial to the stable of medicine.
Summary of the invention
First purpose of the present invention provides a kind of loud, high-pitched sound wood Zhu Er emulsion agent, to satisfy the needs of clinical practice.
Second purpose of the present invention is to provide the preparation method of described loud, high-pitched sound wood Zhu Er emulsion agent.
Described loud, high-pitched sound wood Zhu Er emulsion agent comprises following components in weight percentage:
Described loud, high-pitched sound wood Zhu Er is made up of Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, Borneolum Syntheticum and Moschus 7 flavor medicines, and the parts by weight of each component are:
35 parts of Mirabilitum crystallinas, 10 parts of Realgars, 5 parts in Cinnabaris, 5 parts of Vermilion, 5 parts of Concha Haliotidis, 25 parts of Borneolum Syntheticums, 0.5 part in Moschus;
Take by weighing each component, porphyrize, comminution by gas stream behind the 80 order primary dcreening operations, the particle diameter of 99% powder are less than the powder of 150 μ m, and the particle diameter of preferred 99% powder is less than 100 μ m;
Described bioadhesive polymer be for absorbing water and form the macromolecular material of gel, selects a kind of in the macromolecular material of gelatin substance, synthetic of natural extract or several for use;
The gelatin substance of described natural extract is selected from alginate, arabic gum, Lac, chitosan, tragakanta, pectin or agar etc.;
The macromolecular material of described synthetic is selected from carboxymethyl starch sodium, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate or Polyethylene Glycol etc.;
Described oils and fats is selected from synthetic ester oil such as decanoyl/octanoyl glycerides, vaseline, liquid paraffin, lanoline, dimethicone, hexadecanol, octadecanol, tristerin etc., or natural plant grease such as Oleum Glycines, Oleum Cocois, Oleum Camelliae or Semen arachidis hypogaeae wet goods, or animal oil such as fish oil etc. a kind of or several;
Described nonionic emulsifier is selected from a kind of in tween, span, poloxamer, polyoxyethylene aliphatic alcohol ether, the polyoxyethylene fatty acid ester or several;
Preferably, described loud, high-pitched sound wood Zhu Er emulsion agent comprises following components in weight percentage:
Preparation method of the present invention comprises the following step:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers consumption;
(2) with the bioadhesive polymer of recipe quantity with suitable quantity of water dissolving or swelling after, mix with the medicine of step (1), the consumption of water is 30～80% of total water amount;
(3) with oils and fats and the surplus emulsifier of recipe quantity, can be heated to 50～60 ℃ if needed and melt, add the water of prescription surplus, mix, stir, put the cold Emulsion that gets;
(4) Emulsion of step (3) is joined the product of step (2), mixing namely gets loud, high-pitched sound wood Zhu Er emulsion agent.
Or following steps:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers gross weight consumption;
(2) with the bioadhesive polymer of recipe quantity with behind the water dissolution or swelling of recipe quantity, add the emulsifying agent of surplus, mix with the medicine of step (1);
(3) mixture of step (1) is joined the product of step (2), mixing, namely.
Loud, high-pitched sound wood Zhu Er emulsion agent of the present invention, can be used for treating common gynecological diseases such as cervical erosion, using method is as follows: the vagina that loud, high-pitched sound of the present invention wood Zhu Er emulsion agent is sent into the patient who needs treatment by administrator gets final product, and dosage specifically can be according to patient's age etc., is determined by the doctor; Also can be used for skin diseases, loud, high-pitched sound wood Zhu Er emulsion agent of the present invention directly is applied in the affected part gets final product.
The present invention is combined bioadhesive material with loud, high-pitched sound wood Zhu Er, make the medicine dispersion and adhere to lesions position, reaches therapeutic purposes.And need further be pointed out that, be not that all bioadhesive polymers all are applicable to the present invention, polyacrylate such as carbomer, although its good adhesion is widely used, after loud, high-pitched sound wood Zhu Er contacted, carbomer lost viscosity.In the preparation, earlier with medicated powder and glycerol, emulsifier, not only play good peptizaiton, emulsifying agent also can promote the dissolving of Borneolum Syntheticum and Moschus, the quickening onset.
Compared with prior art, loud, high-pitched sound wood Zhu Er emulsion agent content of dispersion of the present invention is higher, and administration is more convenient, and does not add any zest solvent, prolongs action time; Avoid the heating to medicated powder during preparation, avoided Borneolum Syntheticum in preparation process, to volatilize owing to being heated, guaranteed medicament contg; And in preparation, add an amount of emulsifying agent, can promote the dissolving of Moschus and Borneolum Syntheticum, compare traditional powder type, can accelerate onset time; And add an amount of oils and fats and emulsifying agent, can play good lubrication; Particle diameter to drug powder is optimized, and makes 99% powder less than 100 μ m, improves stability; Medicine itself has antibiotic anti-corrosion function, need not add antiseptic.
The specific embodiment
Embodiment 1
According to the mongolian medicine pharmacopeia, take by weighing Mirabilitum crystallina, Realgar, Concha Haliotidis, Cinnabaris, Vermilion, Moschus, Borneolum Syntheticum in proportion, porphyrize is crossed 80 order primary dcreening operations, and comminution by gas stream obtains required micronization principal agent.
Described loud, high-pitched sound wood Zhu Er is made up of Mirabilitum crystallina, Realgar, Cinnabaris, Vermilion, Concha Haliotidis, Borneolum Syntheticum and Moschus 7 flavor medicines, and the parts by weight of each component are:
35 parts of Mirabilitum crystallinas, 10 parts of Realgars, 5 parts in Cinnabaris, 5 parts of Vermilion, 5 parts of Concha Haliotidis, 25 parts of Borneolum Syntheticums, 0.5 part in Moschus;
Adopt laser diffractometry to measure powder diameter, concrete particle size distribution sees the following form.
| Sample | X 10(μm) | X 50(μm) | X 99(μm) |
| Sample 1 | 1.44 | 8.34 | 99.67 |
| Sample 2 | 1.10 | 3.95 | 59.52 |
| Sample 3 | 1.78 | 13.51 | 146.81 |
Embodiment 2
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 97.5g of embodiment 1 and 150g glycerol, 10g Tween 80 mix homogeneously;
(2) get bioadhesive polymer sodium alginate 2.5g water 64g swelling, add step (1) loud, high-pitched sound wood Zhu Er, mixing;
(3) get octadecanol 30g, white vaseline 20g, glyceryl monostearate 20g, liquid paraffin 30g, lanoline 20g, dimethicone 30g, be mixed and heated to 60 ℃; Add 5g sorbester p17,5g Tween 80 and 16g water, stir, put the cold Emulsion that gets;
(4) with mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, packing, namely.
Embodiment 3
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 200g of embodiment 1 and 100g glycerol, 10g Tween 80 mix homogeneously;
(2) get bioadhesive polymer sodium carboxymethyl cellulose 0.25g water 25g swelling, add step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) get white vaseline 30g, glyceryl monostearate 20g, liquid paraffin 30g, dimethicone 20g, be mixed and heated to 50 ℃; Add 4.75g Tween 80 and 60g water, stir, put the cold Emulsion that gets;
(4) with mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, packing, namely.
Embodiment 4
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 50g of embodiment 1 and 125g glycerol, 8g polyoxyethylene castor oil mix homogeneously;
(2) get bioadhesive polymer hydroxypropyl methylcellulose 15g water 150g swelling, add step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) get white vaseline 10g, glyceryl monostearate 15g, liquid paraffin 10g, lanoline 15g, be mixed and heated to 50 ℃; Add 7g polyoxyethylene castor oil and 95g water, stir, put the cold Emulsion that gets;
(4) with mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, packing, namely.
Embodiment 5
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 100g of embodiment 1 and 25g glycerol, 4g polyoxyethylene castor oil mix homogeneously;
(2) get bioadhesive polymer methylcellulose 40g water 250g swelling, add step (1) loud, high-pitched sound wood Zhu Er, mixing;
(3) get soybean oil 5g, add 1g polyoxyethylene castor oil and 75g water, stir, put the cold Emulsion that gets;
(4) with mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, packing, namely.
Embodiment 6
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 150g of embodiment 1 and 70g glycerol, 0.5g poloxamer mix homogeneously;
(2) get bioadhesive polymer chitosan 30g water 249.5g swelling, add step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) with mixture and step (2) the mixture mix homogeneously of step (1), gross weight is 500g, packing, namely.
Embodiment 7
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 115g of embodiment 1 and 5g glycerol, 15g polyoxyethylene castor oil mix homogeneously;
(2) get bioadhesive polymer hydroxypropyl methylcellulose 5g water 150g swelling, add step (1) loud, high-pitched sound wood Zhu Er, mixing;
(3) get white vaseline 50g, glyceryl monostearate 15g, liquid paraffin 60g is mixed and heated to 50 ℃; Add 10g polyoxyethylene castor oil and 75g water, stir, put the cold Emulsion that gets;
(4) with mixture and step (3) the Emulsion mix homogeneously of step (2), gross weight is 500g, packing, namely.
Embodiment 8
(1) takes by weighing the loud, high-pitched sound wood Zhu Er 125g of embodiment 1 and 130g glycerol, 2.5g Tween 80 mix homogeneously;
(2) get bioadhesive polymer polyvinylpyrrolidone 20g water 220g swelling, add 2.5g Tween 80 and step (1) loud, high-pitched sound wood Zhu Er mixing;
(3) with mixture and step (2) the mixture mix homogeneously of step (1), gross weight is 500g, packing, namely.
Embodiment 9
For estimating the adhesiveness of loud, high-pitched sound wood Zhu Er emulsion agent, adopt agar culture medium simulation physiology mucosa to investigate.Take by weighing agar 0.75g, add 50ml water and stir, be heated to boiling after, be inverted dry culture dish, treat its cooling namely.Press embodiment 2,3,4,6 prescription preparation loud, high-pitched sound wood Zhu Er emulsion agents, and configuration and embodiment 2 prescriptions are identical but do not contain the preparation of bioadhesive polymer, be applied on the agar culture medium, agar culture medium vertically is hung on the disintegration tester hook, place the pH6.8 phosphate buffer in the disintegrate cup, liquid level was not advisable to have the culture medium peak, and the disintegrate temperature is 37 ℃.Start disintegration tester, the time that the record medicine all drops, the results are shown in following table, the adding significant prolongation of bioadhesive polymer medicine adhere to the time.
Embodiment 10
48 of SD rats, the male and female dual-purpose, body weight 200 ± 20g is divided into 4 groups at random.Shaves hair in center, the back of every rat before the experiment, loses hair or feathers with depilatory cream shaving the territory, hair-fields, second day the fresh bacterium liquid of the golden yellow Fructus Vitis viniferae ball of no hair-fields subcutaneous injection 0.2ml (about 500,000,000 antibacterials/ml)/, losing hair or feathers sordid animal need not.Inject and to see after three days that dense lump appears in subcutaneous rat.Each organizes the listed medicine of rat according to the form below and agent is applied in around the lump, every day secondary, totally 10 days.(maximum gauge, cm), and whether record festers to measure the lump size after 10 days.The results are shown in following table.
| Group | Lump size (cm) | Percentage rate does not fester | Begin the detumescence time |
| Matched group | 1.365±0.3 | 33.8％ | - |
| The Mupirocin Ointment group | 0.935±0.188 | 70.0％ | 5 |
| Embodiment 2 | 0.905±0.284 | 75.0％ | 3 |
| Embodiment 6 | 0.925±0.212 | 70.6％ | 3 |
| Loud, high-pitched sound wood Zhu Er powder | 1.012±0.314 | 60.2％ | 5 |
Embodiment 11
Press embodiment 3 configuration samples, in addition, the processing of medicine heating disinfection after 30 minutes, is carried out bacteriostatic test with 3 kinds of standard bacterium, adopt the double dilution method of agar, quantitatively inoculate every some inoculation 10 with multiple spot inoculation instrument
5CFU cultivated 22 hours at 37 ℃, observed and the record result.Result of the test is minimum inhibitory concentration (MIC) with the least concentration of medicine bacteria growing inhibiting, the results are shown in following table, and sample has good bacteriostatic activity, and the MIC of heat treated sample obviously increases, and has destroyed the composition in the prescription, makes antibacterial activity reduce.
Antibacterial activity in vitro is MIC (mg/ml) relatively
| Strain name | The heat treated sample | Untreated samples |
| Golden yellow staphylococcus | 12.5 | 2 |
| Escherichia coli | 3.2 | 2 |
| Bacillus pyocyaneus | 200 | 4 |
Embodiment 12
Loud, high-pitched sound wood Zhu Er emulsion agent is carried out physical stability investigate, blank according to embodiment 2 configurations, and be respectively the loud, high-pitched sound wood Zhu Er powder preparation sample of 59.52,99.67,146.81 and 186.81 μ m with 99% particle diameter; Get an amount of loud, high-pitched sound wood Zhu Er emulsion agent in the centrifuge tube of 1.5ml, with 3000r/m centrifugal 10 minutes, observe in the centrifuge tube particles settling or layering whether occur, the results are shown in following table.
| X 99(μm) | Blank | 59.52 | 99.67 | 146.81 | 186.81 |
| Layering | Do not have | Do not have | Do not have | Do not have | Do not have |
| Particles settling | Do not have | Do not have | Do not have | Seldom | More |
Embodiment 13
Loud, high-pitched sound wood Zhu Er emulsion agent is carried out content of bornyl alcohol to be investigated, prepare each 3 parts in sample respectively according to embodiment 4,8, with the prescription of identical embodiment 4 method of preparing emulsion configuration 3 parts in sample (being labeled as 4 ') routinely, use ethyl acetate extraction respectively, the gas chromatography determination content of bornyl alcohol in addition.Chromatographic condition: be immobile phase with Polyethylene Glycol (PEG)-20M, coating concentration is 10%; Column temperature: 135 ℃; Fid detector; Carrier gas is nitrogen.As interior mark, ethyl acetate is solvent, carries out determination of recovery rates with internal standard method, the results are shown in following table with methyl salicylate.
| Group | Borneolum Syntheticum response rate % |
| Embodiment 4 | 99.32±0.88 |
| Embodiment 6 | 99.75±0.48 |
| 4’ | 90.27±0.81 |
Claims (2)
1. loud, high-pitched sound wood Zhu Er medicine emulsion agent is characterized in that, comprises following components in weight percentage:
Described bioadhesive polymer is selected from alginate, arabic gum, Lac, chitosan, tragakanta, pectin or agar, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate or Polyethylene Glycol;
Described oils and fats is selected from decanoyl/octanoyl glycerides, vaseline, liquid paraffin, lanoline, dimethicone, hexadecanol, octadecanol, tristerin, Oleum Glycines, Oleum Cocois, Oleum Camelliae, Oleum Arachidis hypogaeae semen or fish oil.
Described nonionic emulsifier is selected from a kind of in tween, span, poloxamer, polyoxyethylene aliphatic alcohol ether, the polyoxyethylene fatty acid ester or several;
The preparation method of described loud, high-pitched sound wood Zhu Er medicine emulsion agent comprises the following step:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers consumption;
(2) with the bioadhesive polymer of recipe quantity with suitable quantity of water dissolving or swelling after, mix with the medicine of step (1), the consumption of water is 30～80% of total water amount;
(3) with oils and fats and the surplus emulsifier of recipe quantity, can be heated to 50～60 ℃ if needed and melt, add the water of prescription surplus, mix, stir, obtain Emulsion;
(4) Emulsion of step (3) is joined the product of step (2), mixing namely gets loud, high-pitched sound wood Zhu Er emulsion agent; Or comprise the steps:
(1) with the principal agent micronization of recipe quantity, adds the glycerol moistening, and add an amount of emulsifying agent; Emulsifying dosage is 50～100% of total emulsifiers gross weight consumption;
(2) with the bioadhesive polymer of recipe quantity with behind the water dissolution or swelling of recipe quantity, add the emulsifying agent of surplus, mix with the medicine of step (1);
(3) mixture of step (1) is joined the product of step (2), mixing namely gets described loud, high-pitched sound wood Zhu Er emulsion agent.
2. loud, high-pitched sound wood Zhu Er medicine emulsion agent according to claim 1 is characterized in that, described loud, high-pitched sound wood Zhu Er medicine emulsion agent comprises following components in weight percentage:
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