CN100396290C - External use anti-bacteria foaming agent for gynecology - Google Patents
External use anti-bacteria foaming agent for gynecology Download PDFInfo
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- CN100396290C CN100396290C CNB2006101382136A CN200610138213A CN100396290C CN 100396290 C CN100396290 C CN 100396290C CN B2006101382136 A CNB2006101382136 A CN B2006101382136A CN 200610138213 A CN200610138213 A CN 200610138213A CN 100396290 C CN100396290 C CN 100396290C
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- foaming agent
- external use
- gynecology
- bacteria
- nanometer silver
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Abstract
The invention discloses an external use of gynecology antibiotic foaming agent of silver nanoparticle for treatment of all sorts of vaginitis and cervicitis of women, said foaming agent comprising 50000ppmsilver nanoparticle solution 0.02-4%,sodium dodecylsulfate 0.5-1 0%,glycerine 1 5-25%,tween -80:0.1-5%,sapn -80:0.1-5%,polyvinyl pyrrolidon 2-6%,menthol 0.5-2% and the remainder being purified water to prepare into antibiotic solution ,and adding propellent to obtain said medication.
Description
Technical field
The present invention relates to a kind of non-antibiotic class anti-bacteria foaming agent, relate to the external use anti-bacteria foaming agent for gynecology of various types of vaginitiss of a kind of women of being used for and cervicitis treatment particularly.
Background technology
General in the market gynecological external use antimicrobial drug generally includes suppository and washing liquid etc., though these gynaecologic antibiotic medicines are antibiotic, the curative effect of antiinflammatory aspect has also obtained certainly, but these medicines or foreign body sensation, easy landing pollution clothes are arranged, perhaps action time short, weak curative effect, patient's medication poor compliance.
Summary of the invention
The objective of the invention is at the problems referred to above, the non-antibiotic class external use anti-bacteria foaming agent for gynecology of various types of vaginitiss of a kind of women of being widely used in and cervicitis treatment is provided, it is convenient not only to use, and got rid of general gynecological and foreign body sensation has been arranged with gynecological's articles for use such as suppository and washing liquids, easily landing pollution clothes or action time short, weak curative effect, deficiencies such as patient's medication poor compliance.
For achieving the above object, the technical solution used in the present invention is: a kind of external use anti-bacteria foaming agent for gynecology, make antiseptic solution by 50000ppm nanometer silver solution, sodium lauryl sulphate, glycerol, tween 80, Arlacel-80, polyvinylpyrrolidone, Mentholum and purified water, repress is gone into propellant and is made; The weight percentage ranges of antiseptic solution each component is a nanometer silver solution: 0.02～4%, sodium lauryl sulphate: 0.5～10%, glycerol: 15～25%, tween 80: 0.1～5%, Arlacel-80: 0.1～5%, polyvinylpyrrolidone: 2～6%, Mentholum: 0.5～2%, all the other are purified water; The additional proportion of described propellant is that per hundred parts of antiseptic solutions add 20～35 parts of propellant.
The preferred weight percentage ranges of antiseptic solution each component is: nanometer silver solution: 0.5～2%, sodium lauryl sulphate: 3～7%, glycerol: 18～22%, tween 80: 1.5～3%, Arlacel-80: 1.5～3%, polyvinylpyrrolidone: 3～4%, Mentholum: 1～1.5%, all the other are purified water.
Described propellant can be freon, tetrafluoroethane or dimethyl ether.
Nanometer silver is to utilize nanotechnology with silver-colored nanorize, the appearance of nanotechnology, make small size and the skin effect of silver under the nanometer state significantly strengthen, make its sterilizing ability produce qualitative leap, only the nanometer silver with minute quantity can produce powerful bactericidal action, also has the curative effect of anti-inflammatory property and promotion wound healing simultaneously.
Its antibacterial action mechanism is the skin effect absorption antibacterial by nanometer silver, nanometer silver with positive charge and antibacterial with negative charge react, thereby suppress the breathing of antibacterial, be cell membrane and the thorough deformation fracture of cell wall of antibacterial simultaneously, antibacterial loses breeding and survival ability, and " dissolving is dead " taken place.Nanometer silver itself has superpower degradation function, and when antibacterial is attracted to nanometer silver when surface, its biodegradable superparamagnetic function will be destroyed the enzyme system in the bacterial cell, influences the antibacterial normal metabolic, from but antibacterial death.After finishing sterilization process, nano-particle is difficult for forming in human body and accumulates outside having different body system to discharge to carry with killed bacterial, and is then safer in application.
The antibiotic characteristics of nanometer silver are: the first, and broad-spectrum antiseptic all has in interior multiple pathogen antibacterial, fungus, infusorian, mycoplasma and well to kill the back inhibitory action.The second, the non-antibiotic series bactericidal agent has equal killing power to fastbacteria.After testing, act on 12 hours, nanometer silver more than 99.9%, is 100% to gonococcal killing rate to the killing rate of staphylococcus aureus, escherichia coli, Candida albicans.
External use anti-bacteria foaming agent for gynecology of the present invention has the physics broad-spectrum antiseptic, has no drug resistance, renders a service lasting, characteristics such as chance water sterilizing power is stronger, safety and environmental protection, it is ideal novel gynecological antibacterial anti-inflammation formulation, this product adopts the foam exquisiteness of its generation of foam soft, by full and retention effect, can disperse fast, make principal agent distribute and permeate in agents area with solution state, effect directly, help absorbing, it is more thorough to sterilize, and reaches more efficiently treatment.It is better that the sodium lauryl sulphate that the present invention adopts, tween 80 and span-80 are used into foam effect, glycerol then can play effect lubricated, that preserve moisture, polyvinylpyrrolidone can make medicine longer in the time that intravaginal keeps as adhesive, Mentholum then can overcome the vagina abnormal flavour, and propellant helps to expedite the emergence of the formation foam.External use anti-bacteria foaming agent for gynecology of the present invention can be treated effectively and be comprised bacterial vaginosis, colpitis mycotica, trichomonal vaginitis, vagina mixed infection; The gonococcus sexuality is dyed, mycoplasma (chlamydia) infects; Gynaecopathia such as chronic cervicitis and cervical erosion, in use having overcome has foreign body sensation, easily landing pollution clothes or action time short, weak curative effect, shortcomings such as patient's medication poor compliance.
Clinical test results:
1. vaginitis
The colpitic curative effect of table 1 treatment
2. cervicitis
The curative effect of table 2 treatment cervicitis
Clinical trial proves that said preparation has obvious curative effects to female vagina, cervicitis, does not find untoward reaction in the clinical course, and is easy to use.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment.
Embodiment 1:
With 50000ppm nanometer silver solution 1 gram, sodium lauryl sulphate 1 gram, glycerol 18 grams, tween 80: 1 gram, Arlacel-80: 1 gram, polyvinylpyrrolidone 3 grams, Mentholum: 1 gram, purified water 74 gram mixing and stirring are mixed with 100 gram antiseptic solutions, fill is pressed into Freon 20 and restrains into external use anti-bacteria foaming agent for gynecology of the present invention in hermetic container.
Embodiment 2:
With 50000ppm nanometer silver solution 0.02 gram, sodium lauryl sulphate 10 grams, glycerol 15 grams, tween 80: 5 grams, Arlacel-80: 0.1 gram, polyvinylpyrrolidone 6 grams, Mentholum: 0.5 gram, purified water 63.38 gram mixing and stirring are mixed with 100 gram antiseptic solutions, fill is pressed into freon 35 and restrains into external use anti-bacteria foaming agent for gynecology of the present invention in hermetic container.
Embodiment 3:
With 50000ppm nanometer silver solution 4 grams, sodium lauryl sulphate 0.5 gram, glycerol 25 grams, tween 80: 0.1 gram, Arlacel-80: 5 grams, polyvinylpyrrolidone 2 grams, Mentholum: 2 grams, purified water 63.4 gram mixing and stirring are mixed with 100 gram antiseptic solutions, fill is pressed into tetrafluoroethane 25 and restrains into external use anti-bacteria foaming agent for gynecology of the present invention in hermetic container.
Embodiment 4:
With 50000ppm nanometer silver solution 0.5 gram, sodium lauryl sulphate 7 grams, glycerol 18 grams, tween 80: 3 grams, Arlacel-80: 1.5 grams, polyvinylpyrrolidone 4 grams, Mentholum: 1 gram, purified water 65 gram mixing and stirring are mixed with 100 gram antiseptic solutions, fill is pressed into dimethyl ether 30 and restrains into external use anti-bacteria foaming agent for gynecology of the present invention in hermetic container.
Embodiment 5:
With 50000ppm nanometer silver solution 2 grams, sodium lauryl sulphate 3 grams, glycerol 22 grams, tween 80: 1.5 grams, Arlacel-80: 3 grams, polyvinylpyrrolidone 3 grams, Mentholum: 1.5 grams, purified water 65 gram mixing and stirring are mixed with 100 gram antiseptic solutions, fill is pressed into tetrafluoroethane 35 and restrains into external use anti-bacteria foaming agent for gynecology of the present invention in hermetic container.
Describe the present invention with way of example above, but the invention is not restricted to above-mentioned specific embodiment, all protection domains that all belongs to claim of the present invention based on any improvement that the present invention did or modification.
Claims (3)
1. nanometer silver external use anti-bacteria foaming agent for gynecology, it is characterized in that: make antiseptic solution by 50000ppm nanometer silver solution, sodium lauryl sulphate, glycerol, tween 80, Arlacel-80, polyvinylpyrrolidone, Mentholum and purified water, repress is gone into propellant and is made; The weight percentage ranges of antiseptic solution each component is a nanometer silver solution: 0.02～4%, sodium lauryl sulphate: 0.5～10%, glycerol: 15～25%, tween 80: 0.1～5%, Arlacel-80: 0.1～5%, polyvinylpyrrolidone: 2～6%, Mentholum: 0.5～2%, all the other are purified water; The additional proportion of described propellant is that per hundred parts of antiseptic solutions add 20～35 parts of propellant.
2. external use anti-bacteria foaming agent for gynecology according to claim 1, it is characterized in that: the weight percentage ranges of antiseptic solution each component is a nanometer silver solution: 0.5～2%, sodium lauryl sulphate: 3～7%, glycerol: 18～22%, tween 80: 1.5～3%, Arlacel-80: 1.5～3%, polyvinylpyrrolidone: 3～4%, Mentholum: 1～1.5%, all the other are purified water.
3. gynecological external use antimicrobial drug according to claim 1 and 2 is characterized in that: described propellant is freon, tetrafluoroethane or dimethyl ether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101382136A CN100396290C (en) | 2006-11-03 | 2006-11-03 | External use anti-bacteria foaming agent for gynecology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101382136A CN100396290C (en) | 2006-11-03 | 2006-11-03 | External use anti-bacteria foaming agent for gynecology |
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| Publication Number | Publication Date |
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| CN1943593A CN1943593A (en) | 2007-04-11 |
| CN100396290C true CN100396290C (en) | 2008-06-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006101382136A Expired - Fee Related CN100396290C (en) | 2006-11-03 | 2006-11-03 | External use anti-bacteria foaming agent for gynecology |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107515131A (en) * | 2017-07-28 | 2017-12-26 | 唐旭春 | A kind of preparation method of anti-degradation biological material evidence high efficiency extraction cotton swab |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872159A (en) * | 2012-09-29 | 2013-01-16 | 广东同德药业有限公司 | Nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation, and preparation method thereof |
| CN102872160A (en) * | 2012-10-26 | 2013-01-16 | 广东同德药业有限公司 | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds |
| CN109793714A (en) * | 2018-10-08 | 2019-05-24 | 谢兵 | A kind of gynecological external use foaming agent and preparation method |
| CN111514102A (en) * | 2020-04-30 | 2020-08-11 | 广州市尤特新材料有限公司 | Nano-silver disinfectant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1238947A (en) * | 1998-06-15 | 1999-12-22 | 贵州宏宇药业有限公司 | Foaming medicine for treating gynopathy and preparing process thereof |
| CN1328819A (en) * | 2001-04-20 | 2002-01-02 | 朱红军 | Nanometer silver antimicrobial inflammation-relieving film for curing gynecopathy and its production process |
| CN1369206A (en) * | 2001-12-26 | 2002-09-18 | 骏安科技投资有限公司 | Nano Silver sterilizing gel, its preparing method and use |
| CN1369269A (en) * | 2001-12-26 | 2002-09-18 | 骏安科技投资有限公司 | Nano silver antibacterial film for women its preparing method and use |
| CN1672689A (en) * | 2004-03-26 | 2005-09-28 | 深圳市爱杰特医药科技有限公司 | Nano silver antiseptic gel for treating women's genital tract infection and its prepn and application |
| CN1810256A (en) * | 2005-01-25 | 2006-08-02 | 山东京卫制药有限公司 | Policresulen foam aerosol and its prepn process |
-
2006
- 2006-11-03 CN CNB2006101382136A patent/CN100396290C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1238947A (en) * | 1998-06-15 | 1999-12-22 | 贵州宏宇药业有限公司 | Foaming medicine for treating gynopathy and preparing process thereof |
| CN1328819A (en) * | 2001-04-20 | 2002-01-02 | 朱红军 | Nanometer silver antimicrobial inflammation-relieving film for curing gynecopathy and its production process |
| CN1369206A (en) * | 2001-12-26 | 2002-09-18 | 骏安科技投资有限公司 | Nano Silver sterilizing gel, its preparing method and use |
| CN1369269A (en) * | 2001-12-26 | 2002-09-18 | 骏安科技投资有限公司 | Nano silver antibacterial film for women its preparing method and use |
| CN1672689A (en) * | 2004-03-26 | 2005-09-28 | 深圳市爱杰特医药科技有限公司 | Nano silver antiseptic gel for treating women's genital tract infection and its prepn and application |
| CN1810256A (en) * | 2005-01-25 | 2006-08-02 | 山东京卫制药有限公司 | Policresulen foam aerosol and its prepn process |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107515131A (en) * | 2017-07-28 | 2017-12-26 | 唐旭春 | A kind of preparation method of anti-degradation biological material evidence high efficiency extraction cotton swab |
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| CN1943593A (en) | 2007-04-11 |
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Granted publication date: 20080625 Termination date: 20101103 |