CN1369206A - Nano Silver sterilizing gel, its preparing method and use - Google Patents

Nano Silver sterilizing gel, its preparing method and use Download PDF

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CN1369206A
CN1369206A CN 01143404 CN01143404A CN1369206A CN 1369206 A CN1369206 A CN 1369206A CN 01143404 CN01143404 CN 01143404 CN 01143404 A CN01143404 A CN 01143404A CN 1369206 A CN1369206 A CN 1369206A
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silver
nano
nano silver
gel according
disinfectant gel
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CN 01143404
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程家宠
严季雄
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骏安科技投资有限公司
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Abstract

A disinfecting nano silver gel for treating bacterial vaginitis, prostatitis, burn, scald, wound, etc. contains pharmacologically receptable additive, carrier, and broad-spectrum antibacterial nano silver particles (0.1-0.4%) with 1-100 nm of granularity.

Description

钠米银消毒凝胶及其制备方法和应用 Nano silver sanitizing gels and preparation method and application

一、技术领域本发明是关于一种采用纳米银的抗菌药物,更特别的,是关于一种钠米银消毒凝胶及其制备方法和应用。 I. Technical Field The present invention relates to a nano silver antimicrobial agents employed, more particularly, a silver sodium sanitizing gels meters on its preparation method and application.

银早在远古时代就被应用来治疗刀伤、箭伤,古代三国名医华佗就用银刀为关公刮骨疗伤,《本草纲目》对银的杀菌治病功能已有记载。 As early as in ancient times silver was applied to treat wounds, Jianshang, three ancient doctors Hua Guan Gong to use silver knife is scraped the bone healing, "Compendium of Materia Medica" function silver sterilization treatment have been described. 《基础元素化学》对银这样描述:银作为杀菌药剂具有奇特功效,1%的硝酸银溶液是治疗眼结膜炎的常用药。 "Chemical base element" describes silver: silver as having a peculiar effect sterilization agent, a 1% silver nitrate solution is commonly used drugs in the treatment of conjunctivitis. 金属银具有强烈的杀菌作用,据测算1克银就可以杀灭50吨水里的细菌,而且对人畜无害。 Metallic silver has a strong bactericidal effect, It is estimated that one gram of silver will be 50 tons of water to kill the bacteria, but harmless to humans and animals. 用含银纱布覆盖溃烂伤口,可迅速消除感染,且不粘连皮肉,银丝可用于缝合伤口,银带可用于固定断骨,银片可用于填补脑壳上破洞,银是最早使用的“亲生物金属”。 With silver gauze ulceration wound, can quickly eliminate the infection without blocking flesh, silver can be used to suture a wound, for fixing fractured bone may with silver, a silver sheet can be used to fill the hole in the skull, "was first used argentaffin bio-metal. "

在临床使用方面,抗感染药占了总用药量的三分之一,但不理想,都认为“细菌越来越耐药,抗生素越来越失效”,原因就在于这些抗生素、磺胺类药等均是通过化学结构的改变来阻断或抑制细菌代谢生长,这环节不行,就换一个环节,称为第二代、第三代抗生素,大部分细菌被抑制死亡,但总有些细菌残存下来,它们的下一代就通过改变基因适应这些药物,即产生耐药性。 In terms of clinical use, anti-infective drugs accounted for a third of the total amount, but not ideal, think that "more and more bacteria resistant to antibiotics, more and more failures," The reason is that these antibiotics, sulfa drugs, etc. are blocked by changing the chemical structure or inhibit the growth of bacterial metabolism, which link does not work, you change a link, called the second generation, third generation antibiotics, most bacteria are inhibited die, but some bacteria survived, their generation will adapt to these drugs by changing the gene, i.e. resistance.

三、发明目的本发明的目的之一是提供一种钠米银消毒凝胶。 Third, the object of the invention One object of the present invention is to provide a silver nanometer disinfectant gel.

本发明的目的之二是提供一种治疗细菌性阴道炎的钠米银消毒凝胶。 Second object of the present invention is to provide a bacterial vaginosis silver nanometer disinfectant gel treatment.

本发明的目的之三是提供一种钠米银消毒凝胶的制备方法。 Another object of the present invention is to provide a method for producing a three nanometer disinfectant gel of silver.

本发明的这些以及其它目的将通过下列详细说明和描述来进一步体现和说明。 These and other objects of the present invention will be further illustrated by the following detailed embodied and illustration and description.

四、发明内容 Fourth, the Summary of the Invention

本发明的钠米银消毒凝胶,除含有药学上可接受的附加剂外,还含有广谱抗菌纳米银颗粒,该纳米银颗粒的粒径为1~100纳米,纳米银粒子载在载体上,纳米银颗粒占消毒凝胶重量的0.1~0.4%。 Nano silver disinfectant gel according to the present invention, in addition to containing pharmaceutically acceptable additives, but also contains broad-spectrum antimicrobial silver nanoparticles, the silver nanoparticles of a particle size of 1 to 100 nanometers, nano silver particles on a carrier nanosilver particles comprise 0.1 to 0.4% by weight of disinfectant gel.

进一步的,本发明的钠米银消毒凝胶,除含有药学上可接受的附加剂外,还含有广谱抗菌纳米银颗粒,该纳米银颗粒的粒径为1~100纳米,纳米银粒子载在灯芯草载体上,纳米银颗粒占消毒凝胶重量的1~3%。 Further, the silver nanometer disinfectant gel according to the present invention, in addition to containing pharmaceutically acceptable additives, but also contains broad-spectrum antimicrobial silver nanoparticles, the silver nanoparticles of a particle size of 1 to 100 nanometers, nano silver particles contained rush on the support, the silver nano-particles comprise 1 to 3% by weight of disinfectant gel.

在本发明的钠米银消毒凝胶中,所述的载体可以是植物载体或无机矿物质载体,该种载体具有极大的表面积和数量极多的微孔,所述的药学上可接受的附加剂包括单体载体、表面活性剂、分散剂和透皮促进剂之一或它们的混合物,可以是二者或三者或四者的混合物。 In the silver nanometer disinfectant gel according to the present invention, the carrier may be a plant or an inorganic mineral carrier support, this type of support has extremely large surface area and a great number of micropores, the pharmaceutically acceptable additional agents include monomeric carrier, surfactant, dispersant and one penetration enhancer or a mixture thereof, or a mixture of both may be three or four persons.

本发明的钠米银消毒凝胶,所述的药剂配方为(以1000克凝胶重量计):纳米银颗粒 1~4克, 聚羧乙胺 5~12克,三乙醇胺 8~15毫升, 余量蒸馏水。 Nano silver disinfectant gel according to the present invention, the pharmaceutical formulation is (1000g weight gel): Nano silver particles 1 to 4 grams, polycarboxylic 5 to 12 grams triethylamine, triethanolamine, 8 to 15 mL, margin distilled water.

较好的是,本发明的钠米银消毒凝胶,所述的药剂配方为(以1000克凝胶重量计):纳米银颗粒 1~3克, 聚羧乙胺 6~10克,三乙醇胺 10~15毫升, 余量蒸馏水。 Preferably, the silver nanometer disinfectant gel according to the present invention, the pharmaceutical formulation is (1000g weight gel): Nano silver particles 1 to 3 grams, polycarboxylic 6 to 10 grams triethylamine, triethanolamine 10 to 15 ml, the balance of distilled water.

最好的是,本发明的钠米银消毒凝胶,所述的药剂配方为(以1000克凝胶重量计):纳米银颗粒 1~2克, 聚羧乙胺 7~8克,三乙醇胺 10~12毫升, 余量蒸馏水。 Most preferably, the silver nanometer disinfectant gel according to the present invention, the pharmaceutical formulation is (1000g weight gel): Nano silver particles 1 to 2 grams, polycarboxylic 7 to 8 grams triethylamine, triethanolamine 10 to 12 ml of distilled water balance.

在本发明的钠米银消毒凝胶中,所述的聚羧乙胺(卡波姆)可以用淀粉类衍生物(羧甲基淀粉钠、羟乙基淀粉、预胶化淀粉)、纤维素衍生物(甲基纤维素、羟丙基甲基纤维素、羟丙基纤维素、羟乙基纤维素)、聚乙烯吡咯烷酮、海藻酸黄原胶等合成或天然聚合物之一或混合物代替。 In the silver nanometer disinfectant gel according to the present invention, the polycarboxylate ethylamine (carbomers) may starch derivatives (sodium carboxymethyl starch, hydroxyethyl starch, pregelatinized starch), cellulose one synthetic derivatives (methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose), polyvinyl pyrrolidone, alginic acid, xanthan gum and the like or natural polymers or mixtures instead.

本发明的钠米银消毒凝胶的制备方法,是按配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1~2小时,搅拌下冷却至凝固,分装即可。 Nano silver gel preparation method for disinfecting the present invention is based on the ratio of the amount of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic stir at room temperature and then distilled water was added and stirring was continued for 1 to 2 hours, and cooled under stirring to solidified, dispensing can.

在本发明中,如有必要,还可以增加一些常规的处理方法,当然也可以按实际情况,包括依凭本专业的常规知识省略一个或多个步骤,便能制出合格的产品。 In the present invention, if necessary, can also increase the number of conventional processing methods, of course, may be the actual situation, including relied upon the professional knowledge of conventional omit one or more steps, can qualified products produced.

同理,在本发明中,也可以按照实际需要和提高疗效的目的,增加一些添加剂或主剂,这也在本发明之中。 Similarly, in the present invention, the object can follow the actual needs and to improve the efficacy, increase the number of primary or additive agents, which is also present in the invention.

本发明的钠米银消毒凝胶可以通过阴道给药,治疗细菌性阴道炎,通过直肠给药治疗男性前列腺炎症,通过与其它添加剂或赋形剂结合,制成治疗型面霜、面膜、洗面液、沫浴液等,也可以用于烧烫伤、外伤、手术切口创面感染及溃疡的预防与消毒,促使创面愈合。 Nano silver disinfectant gel according to the present invention can be administered by the vaginal, treatment of bacterial vaginosis, by treatment of male prostatitis rectal administration, by combination with other additives or excipients, made the treatment of type cream, facial mask, liquid face wash , foam baths and the like, may also be used for burns, trauma, surgical incision wound infection and ulcer prevention and disinfection, to promote wound healing.

本发明的抗菌机理是利用经典理论《医用微生物学》中“Ag使菌体变性或沉淀”的原理,由Ag+与菌体蛋白酶的-SH基结合,使以此为必要基的酶丧失活性而无法生存,从而实现杀灭病菌、修复病变组织、促进伤口愈合,具有治疗和预防细菌、真菌的作用。 Antibacterial mechanism of the present invention is the use of the classical theory of "Medical Microbiology" in the "make cell degeneration or precipitation of Ag" principle, Ag + binding by the bacterial protease -SH group, the enzyme group as a necessary loss of activity We can not survive, in order to achieve kill bacteria, to repair diseased tissue, promote wound healing, has the effect of treatment and prevention of bacterial, fungal.

其杀菌机理为: Bactericidal mechanism is: 在本发明中,可以采用广州安信生物科技发展有限公司生产抗菌颗粒,该产品及其制造方法已获得中国专利,专利号为:94118576.1,名称为:长效广谱抗菌颗粒及其制品的制作方法,该专利在此列入以供参考,此微粉上载有的银质粒子,经扫描隧道电子显微镜检测其粒径为1~100纳米。 In the present invention, can be used in Guangzhou An Xinsheng Biological Technology Development Co., antibacterial particles, the product and its manufacturing method has obtained China patent, patent number: 94118576.1, entitled: Method of long-acting broad-spectrum antimicrobial particles and their products , which is hereby included by reference, and some contained on this silver powder particles, by electron scanning tunneling microscope having a particle size of 1 to 100 nanometers.

本发明的产品可以通过阴道或直肠以及直接涂敷在受伤或感染部位给药,也可以涂敷在介质包括织物上给药,在本发明中采用的纳米银的粒径为1~100纳米,并且银质粒子的粒径减小,使处于表面层的原子数迅速增加,导致原配位不足,不饱和键外露增多,原子的表面能增高,所以具有极强的化学活性,加上粒径为纳米级,所以这些纳米银具有很好的透渗能力,同时纳米银的优异的杀菌功能,因此本发明的钠米银消毒凝胶能治疗阴道炎和其他炎症。 The product of the present invention can be applied directly to the vagina or rectum, and the administration site of injury or infection, the administration can also be applied to media comprising the fabric, nanosilver particle size employed in the present invention is from 1 to 100 nanometers, silver particles and the particle size is reduced, the number of atoms in the surface layer is rapidly increased, resulting in shortage in wife, exposed unsaturation increases, the surface energy of atoms is increased, so it is extremely chemically active, with a particle size of nanoscale, these nano-silver having good permeability through capability while excellent bactericidal nanosilver, silver and therefore nanometer disinfectant gel according to the present invention is capable of other inflammatory and treatment of vaginitis.

本发明的钠米银消毒凝胶经过香港大学微生物研究所、中国科学院微生物研究所、中国医学科学院皮肤病、性病研究所(全国性病预防中心),中国预防医学科学院微生物研究所、中国国家北京新药安全评估中心和北京大学物理化学研究所的检测证明,具有长效、高效、广谱杀菌、无毒、无刺激、物过敏、无耐药性,且剂量小,功效高,是理想的天然杀菌材料。 Nano silver gel of the present invention after sterilization Institute of Microbiology, Chinese Academy of Sciences Institute of Microbiology, Chinese Academy of Medical Sciences skin and venereal diseases Institute (National Center for Prevention of STD) Hong Kong University, Chinese Academy of Preventive Medicine Institute of Microbiology, China National Beijing New Drug and detecting proof security assessment Center, Peking University Institute of physical Chemistry, have long-lasting, efficient, broad-spectrum bactericidal, non-toxic, non-irritating, allergy, no drug resistance and dose, high efficacy, is an ideal natural sterilization material.

表1钠米银消毒凝胶对普通耐药致病生物的抑菌、杀菌检测 Table 1 Nano silver antimicrobial sanitizing gels ordinary resistant pathogenic organisms, detecting sterilization

试验结果显示,对以上致病微生物均有强抑性作用,对大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌有杀灭作用,浓度为50ug/ml时,作用30分钟对大肠杆菌的杀灭率达到85.55%,作用24小时对大肠杆菌的杀菌率可达到100%。 The test results showed that, of the above microorganisms are pathogenic role Jiang Yi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa killing effect at a concentration of 50ug / ml, 30 minutes killing effect against Escherichia coli off rate of 85.55%, for 24 hours against E. sterilization rate can reach 100%.

表2钠米银消毒凝胶对性传播疾病病原微生物的抑菌、杀菌检测 Table 2 Nano silver antimicrobial sanitizing gels of the sexually transmitted disease pathogens, detection sterilization

试验结果显示,本发明的纳米凝胶对引起性传播的淋球菌、沙眼依原体均有杀灭作用,当浓度为10ug/ml(相当于十万分之一克)作用1分钟杀灭淋球菌;浓度为2.03ug/ml,作用1分钟即杀灭沙眼依原体。 The results show that the present invention nanogel Neisseria gonorrhoeae cause sexually transmitted C. trachomatis are killing effect, when the concentration of 10ug / ml (equal to ten millionth of a gram) in 1 minute at killing leaching lactis; concentration of 2.03ug / ml, i.e., in 1 minute at killing C. trachomatis.

本品可抑制和杀灭各类细菌,如金黄色葡萄球菌、大肠杆菌、淋球菌、白色念株菌、绿脓杆菌、化脓性链球菌、枯草芽孢杆菌、肺炎杆菌、厌氧菌等致病菌,他可杀灭沙眼依原体。 It can inhibit and kill all kinds of bacteria, such as Staphylococcus aureus, Escherichia coli, Neisseria gonorrhoeae, albicans, Pseudomonas aeruginosa, Streptococcus pyogenes, Bacillus subtilis, Klebsiella pneumoniae, anaerobic bacteria and other pathogenic bacteria, he can kill C. trachomatis. 安全性试验表面本品无毒性,无过敏性,对皮肤、粘膜无刺激性,无致畸作用,起效快、疗效好,无毒副作用。 This surface safety test product is non-toxic, non-allergenic, skin, mucous membrane irritation, no teratogenic effects, fast onset of action, efficacy, toxic side effects.

本品遇水可加速纳米银的释放,故遇水杀菌力更强。 The product water can accelerate the release of nanosilver, the sterilization water it stronger.

在本发明中,所使用时辅剂或添加剂均可以从市场购得,进一步的,也可以采用本行业中常规使用的相类以产品。 In the present invention, when used as adjuvants or additives are commercially available from the market, further, may also be employed similar conventionally used in the industry product.

以下通过具体实施例来进一步说明本发明,但实施例仅用于说明并不能限制本发明范围,在本发明中若非特指所有的份、量均为以总重量为基础的重单位。 The following further illustrated by way of specific embodiments of the invention, but merely to illustrate embodiments and not limit the scope of the present invention, especially in the present invention, if not all parts, amounts are in units of weight based on the total weight.

A、取灯芯草茎髓干料100克,粉碎至毫米级,备用;B、称取5~20克硝酸银溶于500毫升水中和50~100毫升浓氨水中,溶解后稀释至1000毫升,摇匀,再向此溶液中加含3~10克维C的溶液(体积50毫升),立即投入A步骤得到的颗粒,在通风条件下进行浸泡、挤压、然后再浸泡、挤压,随后进行热处理、浸泡、挤压,最后再进行烘干即得要求的广谱抗菌颗粒。 A, rush pith take 100 g dry material, pulverized to a millimeter, standby; B, weigh 5 to 20 g of silver nitrate dissolved in 500 to 100 ml of water and 50 ml of concentrated aqueous ammonia and diluted to 1000 ml dissolved, shake, the solution was again establish conditions under which C 3 ~ 10 (volume 50 ml), and immediately put the particles obtained in step a, in an air soaking, pressing, and then soak, add containing extrusion solution, followed by heat treatment, soaking, squeezing, and finally then dried to obtain broad-spectrum antimicrobial particles required.

例2:按以下比例称取下列原料纳米银颗粒1克,聚羧乙胺6克,三乙醇胺9毫升,蒸馏水9984克。 Example 2: Weigh the following percentages of the following raw materials taking silver nanoparticles 1 g, 6 g triethylamine carbopol, triethanolamine 9 ml, 9984 g of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.5小时,搅拌下冷却至凝固,分装即司。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added and stirring was continued for 1.5 hours with stirring under cooling to solidification, i.e., dispensing Division.

例3:按以下比例称取下列原料:纳米银颗粒3.5克,聚羧乙胺12克,三乙醇胺15毫升, Example 3: The following percentages referred to takes the following materials: 3.5 g of silver nanoparticles polycarboxylate 12 g triethylamine, 15 ml of triethanolamine,

蒸馏水9969.5克。 9969.5 g of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.9小时,搅拌下冷却至凝固,分装即可。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic stir at room temperature and then distilled water was added stirring was continued for 1.9 hours, with stirring under cooling to solidification, can be dispensed.

例4按以下比例称取下列原料:纳米银颗粒2.5克,聚羧乙胺10克,三乙醇胺12毫升,蒸馏水9975.5克。 Example 4 takes the following proportions referred to in the following materials: 2.5 g of silver nanoparticles polycarboxylate 10 g triethylamine, 12 ml of triethanolamine, 9975.5 grams of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.8小时,搅拌下冷却至凝固,分装即可。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added stirring was continued for 1.8 hours, with stirring under cooling to solidification, can be dispensed.

例5按以下比例称取下列原料:纳米银颗粒1.5克,羟乙基淀粉9克,三乙醇胺12毫升,蒸馏水9977.5克。 EXAMPLE 5 The following raw materials were weighed according to the following ratio: 1.5 grams of silver nanoparticles, hydroxyethyl starch 9 g, 12 milliliters of triethanolamine, 9977.5 grams of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.5小时,搅拌下冷却至凝固,分装即可。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added and stirring was continued for 1.5 hours with stirring under cooling to solidification, can be dispensed.

例6按以下比例称取下列原料:纳米银颗粒1.5克,聚羧乙胺8克,三乙醇胺12毫升,蒸馏水9978.5克。 Example 6 Weigh the following percentages of the following ingredients: 1.5 g of silver nanoparticles, carboxyvinyl 8 g triethylamine, 12 ml of triethanolamine, 9978.5 grams of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.5小时,搅拌下冷却至凝固,分装即可。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added and stirring was continued for 1.5 hours with stirring under cooling to solidification, can be dispensed.

例7按以下比例称取下列原料:纳米银颗粒1.7克,聚乙烯吡咯烷酮10克,三乙醇胺12毫升,蒸馏水9976.3克。 Example 7 takes the following proportions referred to in the following materials: silver nanoparticles 1.7 g, 10 g polyvinylpyrrolidone, 12 milliliters of triethanolamine, 9976.3 grams of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.5小时,搅拌下冷却至凝固,分装即可。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added and stirring was continued for 1.5 hours with stirring under cooling to solidification, can be dispensed.

例8纳米银颗粒 1.6克, 聚乙烯吡咯烷酮 5克,甲基纤维素 4克, 三乙醇胺 12毫升,蒸馏水9977.4克。 Silver nanoparticles Example 8 1.6 g, 5 g polyvinylpyrrolidone, methyl cellulose, 4 g, 12 milliliters of triethanolamine, 9977.4 grams of distilled water.

按以下方法制备:按上述配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1.5小时,搅拌下冷却至凝固,分装即可。 It was prepared as follows: the above-described blend ratio of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added and stirring was continued for 1.5 hours with stirring under cooling to solidification, can be dispensed.

Claims (10)

1.一种钠米银消毒凝胶,其特征在于除含有药学上可接受的附加剂外,还含有广谱抗菌纳米银颗粒,该纳米银颗粒的粒径为1~100纳米,纳米银粒子载在载体上,纳米银颗粒占消毒凝胶重量的0.1~0.4%。 A Nano silver sanitizing gels, characterized in that in addition to containing pharmaceutically acceptable additives, but also contains broad-spectrum antimicrobial silver nanoparticles, the silver nanoparticles of a particle size of 1 to 100 nm, silver nanoparticles on a carrier, nano-silver particles comprise 0.1 to 0.4% by weight of disinfectant gel.
2.如权利要求1所述的钠米银消毒凝胶,其特征在于除含有药学上可接受的附加剂外,还含有广谱抗菌纳米银颗粒,该纳米银颗粒的粒径为1~100纳米,纳米银粒子载在灯芯草载体上,纳米银颗粒占消毒凝胶重量的1~3%。 2. Nano silver disinfectant gel according to claim 1, characterized in that in addition to containing pharmaceutically acceptable additives, but also contains broad-spectrum antimicrobial silver nanoparticles, the silver nanoparticles of a particle size of 1 to 100 nano nano silver particles supported on the carrier rush nanosilver particles comprise 1 to 3% by weight of disinfectant gel.
3.如权利要求1所述的钠米银消毒凝胶,其特征在于所述的载体可以是植物载体或无机矿物质载体,该种载体具有极大的表面积和数量极多的微孔。 Nano silver disinfectant gel according to claim 1, characterized in that said carrier support may be a plant or an inorganic mineral carrier, the carrier having this type of extremely large surface area and a great number of micropores.
4.如权利要求1所述的钠米银消毒凝胶,其特征在于所述的药学上可接受的附加剂包括单体载体、表面活性剂、分散剂和透皮促进剂。 4. Nano silver disinfectant gel according to claim 1, wherein the pharmaceutically acceptable additives include monomeric carrier, a surfactant, a dispersing agent and penetration enhancer.
5.如权利要求1~4所述的钠米银消毒凝胶,其特征在于所述的药剂配方为(以1000克凝胶重量计):纳米银颗粒 1~4克, 聚羧乙胺 5~12克,三乙醇胺 8~15毫升, 余量蒸馏水。 5 polycarboxylates ethanamine silver nanoparticles having 1 to 4 grams: Nano silver as claimed disinfectant gel according to claim 1 to 4, wherein said pharmaceutical formulation is (weight to 1000 g gel) to 12 grams, 8 to 15 milliliters of triethanolamine, the balance of distilled water.
6.如权利要求5所述的钠米银消毒凝胶,其特征在于所述的药剂配方为(以1000克凝胶重量计):纳米银颗粒 1~3克, 聚羧乙胺 6~10克,三乙醇胺 10~15毫升, 余量蒸馏水。 6. Nano silver disinfectant gel according to claim 5, wherein said pharmaceutical formulation is (1000g weight gel): Nano silver particles 1 to 3 grams, polycarboxylic ethylamine 6-10 g, 10 to 15 ml of triethanolamine, the balance of distilled water.
7.如权利要求5所述的钠米银消毒凝胶,其特征在于所述的药剂配方为(以1000克凝胶重量计):纳米银颗粒 1~2克, 聚羧乙胺 7~8克,三乙醇胺 10~12毫升, 余量蒸馏水。 7. Nano silver disinfectant gel according to claim 5, wherein said pharmaceutical formulation is (1000g weight gel): Nano silver particles 1 to 2 grams, polycarboxylic ethylamine 7-8 g, 10 to 12 milliliters of triethanolamine, the balance of distilled water.
8.如权利要求5所述的钠米银消毒凝胶,其特征在于所述的聚羧乙胺可以用淀粉类衍生物、纤维素衍生物、聚乙烯吡咯烷酮、海藻酸黄原胶之一或混合物代替。 8. Nano silver disinfectant gel according to claim 5, wherein said polycarboxylic amine starch derivatives can be used, one of cellulose derivatives, polyvinylpyrrolidone, alginic acid or xanthan gum It was used instead.
9.如权利要求5~7所述的钠米银消毒凝胶的制备方法,其特征在于按配比量将纳米银颗粒、聚羧乙胺和三乙醇胺在室温下搅拌均匀,然后再加入蒸馏水继续搅拌1~2小时,搅拌下冷却至凝固,分装即可。 9. The method of preparing the silver Nano 5 to disinfectant gel according to claim 7, characterized in that the ratio by amount of silver nanoparticles, triethylamine, and triethanolamine polycarboxylic was stirred at room temperature uniformity, and then distilled water was added to continue stirred for 1 to 2 hours, with stirring under cooling to solidification, can be dispensed.
10.如权利要求1~3所述的钠米银消毒凝胶的应用,其特征在于可以通过阴道给药,治疗细菌性阴道炎。 10. Application of Nano silver disinfectant gel according to claim 1 to 3, characterized in that it can be administered through the vaginal, treatment of bacterial vaginosis.
CN 01143404 2001-12-26 2001-12-26 Nano Silver sterilizing gel, its preparing method and use CN1369206A (en)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005120173A3 (en) * 2004-05-12 2006-04-27 Kishore Madhukar Paknikar Anti-microbial activity of biologically stabilized silver nano particles
WO2007017901A2 (en) * 2005-06-08 2007-02-15 Khandelwal Sanjeev Silver nanoparticle dispersion formulation
CN100396290C (en) 2006-11-03 2008-06-25 段炬红 External use anti-bacteria foaming agent for gynecology
CN100425375C (en) 2006-04-03 2008-10-15 庄 平;严国兴 Nano-class silver colloidal solution and preparation method thereof
CN100457084C (en) 2006-08-04 2009-02-04 武汉正午阳光医药生物科技有限公司 Nanometer silver type external use antibiotic gel for female external use and its preparation method
CN102310200A (en) * 2011-08-24 2012-01-11 明基材料有限公司 Nano silver particle forming method
US8192764B2 (en) 2006-01-13 2012-06-05 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
US8399027B2 (en) 2005-04-14 2013-03-19 3M Innovative Properties Company Silver coatings and methods of manufacture
CN103083472A (en) * 2013-01-25 2013-05-08 北海光谷纳米科技研发中心 Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof
CN103493849A (en) * 2013-08-27 2014-01-08 利辛县永强精炼油脂厂 Rose essential oil disinfection gel
CN106074364A (en) * 2016-07-20 2016-11-09 国家纳米科学中心 Antibacterial gel containing nano gold

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005120173A3 (en) * 2004-05-12 2006-04-27 Kishore Madhukar Paknikar Anti-microbial activity of biologically stabilized silver nano particles
US8399027B2 (en) 2005-04-14 2013-03-19 3M Innovative Properties Company Silver coatings and methods of manufacture
WO2007017901A2 (en) * 2005-06-08 2007-02-15 Khandelwal Sanjeev Silver nanoparticle dispersion formulation
WO2007017901A3 (en) * 2005-06-08 2007-06-14 Khandelwal Sanjeev Silver nanoparticle dispersion formulation
US9289450B2 (en) 2006-01-13 2016-03-22 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
US8192764B2 (en) 2006-01-13 2012-06-05 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
CN100425375C (en) 2006-04-03 2008-10-15 庄 平;严国兴 Nano-class silver colloidal solution and preparation method thereof
CN100457084C (en) 2006-08-04 2009-02-04 武汉正午阳光医药生物科技有限公司 Nanometer silver type external use antibiotic gel for female external use and its preparation method
CN100396290C (en) 2006-11-03 2008-06-25 段炬红 External use anti-bacteria foaming agent for gynecology
CN102310200B (en) 2011-08-24 2014-09-03 明基材料有限公司 Nano silver particle forming method
CN102310200A (en) * 2011-08-24 2012-01-11 明基材料有限公司 Nano silver particle forming method
CN103083472A (en) * 2013-01-25 2013-05-08 北海光谷纳米科技研发中心 Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof
CN103493849A (en) * 2013-08-27 2014-01-08 利辛县永强精炼油脂厂 Rose essential oil disinfection gel
CN106074364A (en) * 2016-07-20 2016-11-09 国家纳米科学中心 Antibacterial gel containing nano gold

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