CN103083472A - Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof - Google Patents
Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof Download PDFInfo
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- CN103083472A CN103083472A CN2013100289869A CN201310028986A CN103083472A CN 103083472 A CN103083472 A CN 103083472A CN 2013100289869 A CN2013100289869 A CN 2013100289869A CN 201310028986 A CN201310028986 A CN 201310028986A CN 103083472 A CN103083472 A CN 103083472A
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Abstract
The invention discloses a nano silver anti-inflammatory gel for treating gynecologic inflammation and a preparation method thereof. The gynecologic inflammation is a common frequently-occurring disease; and an ideal effect cannot be easily obtained from the traditional therapeutic drug. 1000g of gel is prepared from 100-200 PPM of nano silver powder, 2-3g of camellia oil, 2-3g of eucalyptus oil, 0.002-0.008g of sodium dodecyl sulfate, 10-20g of propolis, 4-6g of carbopol, 4-6g of triethanolamine and the balance of pure water. The nano silver anti-inflammatory gel has excellent curative effect on pathogenic microorganism infective inflammation diseases such as gynecologic inflammation, cervicitis, or mixed infection. The gel disclosed by the invention is directly administered through vagina; and the drug directly achieves the focus of infection, and is explicit in targeting property, concise and convenient. The nano silver anti-inflammatory gel has strong inhibiting or killing roles on various pathogens such as gram positive bacteria, gram negative bacteria, mould, trichomonad and the like by experimental and clinical validation. The nano silver anti-inflammatory gel has good curative effect on colpitis, cervicitis, annexitis and pelvic inflammation caused by lactobacillus, mycete, candida albicans, HPV (human papillomavirus) and the like.
Description
Technical field
The present invention relates to a kind of nanometer silver antiinflammatory gel and preparation method for the treatment of gynecological inflammation, belong to the medicine preparing technical field.
Background technology
By the gynecological inflammation that antibacterial, virus, fungus and infusorian cause, be common and frequently-occurring disease, usually cause that pain appears in female sex organs, vagina, the phenomenon such as itch, swell, fester, women and kinsfolk's thereof physical and mental health has been caused considerable influence.Although it is more to treat in the market product, because of aspect Shortcomings such as dosage form, using method, curative effects, is difficult to obtain ideal effect.At present, the product for the treatment of gynecological inflammation is mainly the antibiotic of broad-spectrum antiseptic, but the antibiotic life-time service, easily produce drug resistance, also can produce adverse side effect to human body, affect the health of human body, so the general treatment effect is bad, treatment cycle is long, and relapse rate is high.
Therefore, seek a kind of different general antibiotic, both had stronger antibacterial action, can not produce the product of drug resistance simultaneously, especially necessary.As everyone knows, argent has bactericidal action, but its bactericidal action is with relevant with the surface area that antibacterial contacts with it, pathogenic microorganism in gynecological inflammation is all the infection in the human body deep, and pharmaceutical compositions is difficult to arrive, so in prior art, although the bactericide containing silver that uses is more, effect has certain limitation, and curative effect is not very desirable.Hence one can see that, and the use of silvery agent in gynecological inflammation exists the obstacle of going beyond, and overcoming this obstacle is the technical problem to be solved in the present invention.
Summary of the invention
The object of the present invention is to provide a kind of nanometer silver antiinflammatory gel for the treatment of gynecological inflammation, especially a kind of argent antiinflammatory gel of 1-5 nanometer, overcome existing argent and can only reach the above technology of 30 nanometers, not good to the gynecological inflammation therapeutic effect, easily produce recurrence, the shortcoming that treatment cycle is long.
Another object of the present invention is to provide the preparation method of the nanometer silver antiinflammatory gel of above-mentioned treatment gynecological inflammation.
To achieve these goals, the present invention has taked such technical measures, and a kind of nanometer silver antiinflammatory gel for the treatment of gynecological inflammation when the weight of described nanometer silver antiinflammatory gel is 1000 gram, contains:
Nanometer silver powder 100PPM one 200PPM Camellia oil 2-3 gram Oleum Eucalypti 2-3 gram
Dodecyl sodium sulfate 0.002-0.008 gram propolis 10-20 gram carbomer 4-6 gram triethanolamine 4-6 gram surplus is pure water;
Described nanometer silver refers to the argent microgranule that particle diameter is the 1-5 nanometer, and making and selling businessman is Hunan optical valley nanosecond science and technology company limited, and the authentication code of operative norm is that (Hunan) defends No. (0006), the card word (2012) of disappearing;
Described Camellia oil refers to the oiliness composition that is extracted by Flos Camelliae Japonicae tree fruit, existing merchandise sales;
Described Oleum Eucalypti refers to the oiliness composition that is extracted by eucalyptus leaves, existing merchandise sales;
Described propolis refers to Apis and adopts next resinae and Wax from plant;
The pure water that meets national standard that described pure water refers to;
Described all the other raw materials are the kind that Chinese Pharmacopoeia records, and merchandise sales are all arranged.
The preparation method of above-mentioned raw materials is:
(1) get nanometer silver and add together with carbomer, triethanolamine and pure water in ultrasonic disperser and to disperse 2-5 minute, utilize ultrasound wave that the nanometer silver powder is impacted and be uniformly dispersed, obtain slurry standby;
(2) add again all the other raw materials in slurry, be placed in agitator, stirring at normal temperature 30-50 minute, mix, form gel, packing and get final product.
The Antibacterial Mechanism of gel of the present invention:
1. nanometer silver by in the dehydrogenase of depending on for existence in thalline-the SH group converts a SAg to, makes the enzyme loss of activity, causes pathogenic bacteria dead, and its product is enzyme-2SAg and H2O, do not have the secondary paathogenic factor.
2. the glucan binding domian on nanometer silver and bacteria cell wall, blocking-up oxygen enters intracellular approach outside bacterial cell, make antibacterial carry out homergy and death.
3. the DNA base combination of nanometer silver and antibacterial, the structure of change DNA, nanometer silver has also destroyed the DNA replication dna enzyme simultaneously, and when stoping pathogenic bacteria to be copied, DNA is double-stranded separates, thus kill bacteria.
4. nanometer silver destroys cell membrane and the cell wall of antibacterial, causes reducing sugar a large amount of in the antibacterial born of the same parents, protein and potassium ion to be revealed, transmembrane potential and ATP approach exhaustion, thus the antibacterial homergy is dead by heavy damage.
take the gel of the present invention of above-mentioned measure, to the treatment gynecological inflammation, as vaginitis, the pathogenic microorganism infection such as cervicitis or mixed infection inflammation disease, all has excellent curative effect, gel of the present invention is by the direct administration of vagina, the medicine focus of going directly, targeting is clear and definite, succinct convenient, because the particle diameter of the nano silver particles of gel of the present invention is little, be only 1-5 nm, narrow distribution range, specific surface area is large, so that be in the electron number of surface layer and increase sharply, cause former coordination not enough, unsaturated bond exposes and increases, the surface of atom can be increased, so have extremely strong chemism, add that particle diameter is little, so good penetrability, can directly act on the affected part, directly enter effect in the pathogenic bacteria body, bactericidal property is good, has broad spectrum antibacterial.Carried out following bacteriostatic test with gel of the present invention: get respectively staphylococcus, bacillus pyocyaneus, Candida albicans is made into bacteria suspension, get respectively bacteria suspension 100ul and add 1ml gel of the present invention, mixing is coated in the PDA culture medium, cultivated 7 days for 24 ℃, result is that clump count is zero.Illustrate that gel of the present invention has stronger inhibition or killing action to multiple pathogens such as gram-positive bacterium, gram negative bacteria, mycete, infusorian.With gel of the present invention, rabbit is carried out the skin irritation toxicity test: the product through smearing 50O0 mg/kg body weight is to 3 Female rabbits, observe after 2 days, all rabbit all survive, skin do not have obvious abnormal response and body weight gain normal, avirulence of the present invention is described, without anaphylaxis, nonirritant.Therefore it is rapid-action that product of the present invention has, good effect has no side effect, and does not affect the characteristics of vagina normal flora and vagina acid-base degree, and bactericidal action is not affected by the PH value yet.Gel process for preparing of the present invention is simple, and product can be encased in gel medicine device, directly is used in patient part, and using method is simple, convenient, effectively.
gel of the present invention is used for the treatment of gynecological inflammation, especially to lactobacillus, mycete, Candida albicans, the vaginitis that HPV etc. cause, cervicitis, adnexitis, pelvic inflammation has good curative effect, through clinical verification, press 3 g/timess with gel of the present invention, every day, the amount of 1 time was carried out vagina administration, in Beihai Maria hospital, Beihai core Ji hospital, North Sea Bo Hua hospital, rich and honour Lu Jianlong clinic, the North Sea and Ba Ma county people's hospital, the Ba Ma county hospitals of ethnic minority medicine have carried out clinical verification: the checking number: 100 people, the women, age 20-45 year, diagnose according to diagnostic criteria, vaginitis 55 examples wherein, endometritis 12 examples, cervicitis 19, adnexitis 14, above-mentioned case disease sees that vagina very itches, the uterine cavity edema, body fluid oozes out, heating, shiver.Press above-mentioned dosage and method administration 10 days, make a definite diagnosis from describing inspection by the patient, stench, the transference cure that generates heat, shivers, every clinical indices all takes a turn for the better, and transference cure is regarded as produce effects, and effective percentage is 100%.By above-mentioned clinical effectiveness as can be known, the treatment works well to gynecological inflammation for gel of the present invention.
In addition; gel of the present invention also can be used for the infection such as department of dermatologry, surgery are treated; can also be used for cosmetics; play antibacterial action; protection skin; such as: to common skin diseases such as acne vulgariss, the gel of the present invention of low concentration all has very strong inhibition or killing action to propionibacterium acnes, bran pityrosporion ovale, staphylococcus epidermidis.A small amount of nanometer silver reaches the effect of thorough radical cure because its tiny particle diameter can infiltrate human body skin to be killed on the obstinate antibacterial in skin depths.Nano silver gel is easy to use, and skin is not had zest.The human body skin contact test proves this gel to the human body skin nonirritant, and has high-efficiency antimicrobial, thus for department of dermatologry and surgery catch and the protection of skin has obvious effect.
The specific embodiment
Embodiment 1
The gel of the present embodiment preparation is 1000 grams;
Formula:
Nanometer silver powder 100PPM Camellia oil 2 gram Oleum Eucalypti 3 grams
Propolis 10 gram carbomer 4 gram triethanolamine 4 grams
Dodecyl sodium sulfate 0.002 gram pure water 76.9 grams;
Preparation method:
(1) above raw material mixing is added in ultrasonic disperser, open ultrasonic disperser and disperseed 2 minutes, obtain slurry, then slurry is placed in agitator, stirred 2 hours, make its mix homogeneously, form gel;
(2) then divide and install in gelatinous medicine feeding device, add outer package, obtain containing gel 1000 grams of nanometer silver concentration 100PPM, every in-built 3g product of gelatinous medicine feeding device.
Embodiment 2
The gel of the present embodiment preparation is 1000 grams;
Formula:
Nanometer silver powder 200PPM Camellia oil 3 gram Oleum Eucalypti 2 grams
Propolis 20 gram carbomer 6 gram triethanolamine 6 grams
Dodecyl sodium sulfate 0.008 gram pure water 962.8 grams
Preparation method:
(1) identical with embodiment 1, obtain containing gel 1000 grams of nanometer silver concentration 200PPM, every in-built 3g product of gelatinous medicine feeding device.
Embodiment 3
The present embodiment prepares gel 1000 grams;
Formula:
Nanometer silver powder 150PPM carbomer 4.4g triethanolamine 4.4g
Propolis 15g Camellia oil 2.5 gram Oleum Eucalypti 2.5g
Dodecyl sodium sulfate 0.005g
Pure water 971.2g
(1) identical with embodiment 1, just mixing time is 1 hour, obtains containing gel 1000 grams of nanometer silver concentration 150PPM, every in-built 3g product of gelatinous medicine feeding device.
Claims (2)
1. nanometer silver antiinflammatory gel for the treatment of gynecological inflammation is characterized in that containing when the weight of described gel is 1000 gram:
Nanometer silver powder 100PPM one 200PPM Camellia oil 2-3 gram Oleum Eucalypti 2-3 gram
Dodecyl sodium sulfate 0.002-0.008 gram propolis 10-20 gram carbomer 4-6 gram
Triethanolamine 4-6 gram surplus is pure water;
Described nanometer silver refers to the argent microgranule that particle diameter is the 1-5 nanometer, and making and selling businessman is Hunan optical valley nanosecond science and technology company limited, and the authentication code of operative norm is that (Hunan) defends No. (0006), the card word (2012) of disappearing;
Described Camellia oil refers to the oiliness composition that is extracted by Flos Camelliae Japonicae tree fruit, existing merchandise sales;
Described Oleum Eucalypti refers to the oiliness composition that is extracted by eucalyptus leaves, existing merchandise sales;
Described propolis refers to Apis and adopts next resinae and Wax from plant.
2. a kind of preparation method for the treatment of the nanometer silver antiinflammatory gel of gynecological inflammation according to claim 1 is characterized in that the concrete steps of described method are:
(1) get nanometer silver and add together with carbomer, triethanolamine and water in ultrasonic disperser and to disperse 2-5 minute, utilize ultrasound wave that the nanometer silver powder is impacted and be uniformly dispersed, obtain slurry standby;
(2) add all the other raw materials in slurry again, be placed in agitator, stirring at normal temperature mixed by 50 minutes in 30 minutes, formed gel, packing and get final product.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103908473A (en) * | 2014-03-28 | 2014-07-09 | 湖南省轻工投资有限公司 | Nano-sliver anti-cancer composition for treating and preventing female carcinoma of uterine cervix as well as preparation method and application thereof |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN104491838A (en) * | 2014-12-19 | 2015-04-08 | 海南森瑞谱生命科学药业股份有限公司 | Anti-HPV (human papillomavirus) gel dressing and preparation method thereof |
| CN105434466A (en) * | 2015-12-07 | 2016-03-30 | 刘传新 | Cervical disease prevention and treatment suppository and preparation method thereof |
| WO2016127724A1 (en) * | 2015-02-10 | 2016-08-18 | 长沙迪谷纳米生物科技有限公司 | Pharmaceutical nano silver paste and preparation method therefor |
| CN107714733A (en) * | 2017-11-28 | 2018-02-23 | 吉安市御美丽健康产业股份有限公司 | A kind of preparation method of antibacterial peptide gynaecologic washing lotion |
| CN110625130A (en) * | 2019-10-11 | 2019-12-31 | 深圳埃米迦医药生物科技有限公司 | Eimeria silver, external gel of Eimeria silver, preparation method and application |
| CN111388414A (en) * | 2020-03-06 | 2020-07-10 | 深圳埃米迦医药生物科技有限公司 | Application of silver amethoxide antiviral solution in preparation of medicine for resisting HPV (human papillomavirus) |
| CN113274487A (en) * | 2021-04-30 | 2021-08-20 | 杭州易启麦生物科技有限责任公司 | A natural herbal topical preparation with effects of resisting HPV virus, treating gynecological inflammation and promoting health, and its preparation method |
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| CN103908473A (en) * | 2014-03-28 | 2014-07-09 | 湖南省轻工投资有限公司 | Nano-sliver anti-cancer composition for treating and preventing female carcinoma of uterine cervix as well as preparation method and application thereof |
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| CN103908473B (en) * | 2014-03-28 | 2016-08-17 | 长沙迪谷纳米生物科技有限公司 | Treat and prevent the application of the nanometer silver anti-cancer composition of uterus neck cancer |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN104491838A (en) * | 2014-12-19 | 2015-04-08 | 海南森瑞谱生命科学药业股份有限公司 | Anti-HPV (human papillomavirus) gel dressing and preparation method thereof |
| CN104491838B (en) * | 2014-12-19 | 2017-04-19 | 海南森瑞谱生命科学药业股份有限公司 | Anti-HPV (human papillomavirus) gel dressing and preparation method thereof |
| WO2016127724A1 (en) * | 2015-02-10 | 2016-08-18 | 长沙迪谷纳米生物科技有限公司 | Pharmaceutical nano silver paste and preparation method therefor |
| CN105434466A (en) * | 2015-12-07 | 2016-03-30 | 刘传新 | Cervical disease prevention and treatment suppository and preparation method thereof |
| CN107714733A (en) * | 2017-11-28 | 2018-02-23 | 吉安市御美丽健康产业股份有限公司 | A kind of preparation method of antibacterial peptide gynaecologic washing lotion |
| CN110625130A (en) * | 2019-10-11 | 2019-12-31 | 深圳埃米迦医药生物科技有限公司 | Eimeria silver, external gel of Eimeria silver, preparation method and application |
| CN110625130B (en) * | 2019-10-11 | 2022-03-18 | 深圳埃米迦医药生物科技有限公司 | Eimeria silver, external gel of Eimeria silver, preparation method and application |
| CN111388414A (en) * | 2020-03-06 | 2020-07-10 | 深圳埃米迦医药生物科技有限公司 | Application of silver amethoxide antiviral solution in preparation of medicine for resisting HPV (human papillomavirus) |
| CN113274487A (en) * | 2021-04-30 | 2021-08-20 | 杭州易启麦生物科技有限责任公司 | A natural herbal topical preparation with effects of resisting HPV virus, treating gynecological inflammation and promoting health, and its preparation method |
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Application publication date: 20130508 |