CN106309237A - Hyaluronic acid private part care gel and preparation method thereof - Google Patents
Hyaluronic acid private part care gel and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses hyaluronic acid private part care gel, prepared from the following component by mass percent: 0.5-3.0% of hyaluronic acid, 8.0-15.0% of a plant extract, 0.1-0.2% of dipotassium glycyrrhizinate, 1.0-5.0% of a humectant, 0.1-0.5% of a filling agent, 0.05-0.5% of a preservative, 1.0-5.0% of a thickening agent, 0.1-1.0% of a pH regulator and the balance of deionized water, wherein the sum of the mass percents of all the components is equal to 100%, and the hyaluronic acid has anti-inflammatory and bacteriostatic activity. The hyaluronic acid private part care gel provided by the invention has the functions of safely inhibiting and killing bacteria, diminishing inflammation, detoxifying and resisting allergy, is capable of solving multiple problems of gynecological inflammation, and has the effects of alleviating vaginal relaxation and restoring the vaginal tight state. Furthermore, the invention also discloses a preparation method of the hyaluronic acid private part care gel; the preparation method has the advantages of being simple and convenient.
Description
Technical field
The present invention relates to feminine care products field, more particularly to a kind of hyaluronic acid private portion's nursing gel and preparation side
Method.
Background technology
The Women of childbearing age of 95% suffers from gynecological inflammation in various degree according to investigations, and women is often staying up late, catches a cold or going on business
Etc. situation time resistance decline, the noxious bacteria in private portion understands Fast-propagation, the symptom such as pruritus, abnormal flavour occurs.Women private portion at present
The sterilizing function of articles for use is mainly realized by interpolation chemical substance, uses chemical method to sterilize, but these chemistry kill
Microbial inoculum is bigger to the skin irritation in private portion, is easily destroyed the weakly acidic condition in private portion, makes the self-cleaning function in private portion weaken, and more
Bacteria breed is easily made to cause discomfort, so chemical bactericide is the safest for the nursing of private portion；Additionally these women private portions use
Product do not treat and prevent the effect in terms of gynecological inflammation problem, have much room for improvement in terms of mildness and combination property yet.
Summary of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, it is provided that one has the most antibacterial and kills
Bacterium, antiinflammatory, removing toxic substances, effect of antiallergic, can solve multiple gynecological inflammatory problems and improve slack vagina, recovers vagina and compacts shape
The hyaluronic acid private portion nursing gel of state, also provides for the preparation method of this hyaluronic acid private portion nursing gel.
For solve above-mentioned technical problem, the present invention by the following technical solutions:
A kind of hyaluronic acid private portion nursing gel, comprises the component of following mass percent,
Each constituent mass percentage ratio summation is 100%, and above-mentioned hyaluronic acid has antiinflammatory bacteriostatic activity, above-mentioned plant extract
Thing is camomile extract, Princepia utilis extract and Flos Chrysanthemi Indici extract arbitrary proportion compositions.
Above-mentioned wetting agent is any one or two or more mixture, preferably glycerine of alcohols, glycerol, hyaluronic acid.
Above-mentioned filler be sodium chloride or disodiumedetate any one.
Above-mentioned thickening agent be carbomer, hydroxyethyl cellulose, carbomer and the mixture of carboxymethyl cellulose arbitrary proportion,
Sodium alginate and the mixture of carboxymethyl cellulose arbitrary proportion, chitosan and the mixture of carboxymethyl cellulose arbitrary proportion,
At least one in the mixture of sodium polyacrylate and acrylic copolymer arbitrary proportion.
Above-mentioned PH regulator be lactic acid or citric acid or potassium hydroxide any one, PH regulator regulation pH value is 4.5-
5.5。
As a total inventive concept, the present invention also provides for the preparation side of a kind of above-mentioned hyaluronic acid private portion nursing gel
Method, comprises the following steps successively:
(1) hyaluronic acid, plant extract, glycyrrhizic acid dipotassium are sequentially added into deionized water, put in homogenizer, 20
At DEG C-60 DEG C, process 5min-30min with 500rmp-5000rmp rotating speed, be completely dissolved to three, mix homogeneously；
(2) the most successively wetting agent, filler and preservative are added in homogenizer, at 20 DEG C-60 DEG C, with
500rmp-5000rmp rotating speed processes 5min-20min so that it is be completely dissolved, mix homogeneously；
(3) again thickening agent is added in homogenizer, at 20 DEG C-60 DEG C, process with 500rmp-5000rmp rotating speed
30min-120min, makes thickening agent be completely dissolved, mix homogeneously；
(4) being eventually adding PH regulator, regulation pH value is 4.5-5.5, makes gel.
Compared with prior art, it is an advantage of the current invention that:
The hyaluronic acid that the hyaluronic acid private portion nursing gel of the present invention contains has antiinflammatory bacteriostatic activity, plant extract
With glycyrrhizic acid dipotassium, there is to hyaluronic acid synergism and having to improve slack vagina and recover effect of vagina tight, three
Person coordinate make the hyaluronic acid private portion nursing gel of the present invention women private portion is had safe sterilization, antibacterial, antiinflammatory, removing toxic substances,
Antiallergic, deodorization, can solve multiple gynecological inflammatory problems and improve slack vagina, recovers effect of vagina tight；Simultaneously
Control the pH value of hyaluronic acid private portion nursing gel so that women private portion maintains weakly acidic condition, after using one section of process, improve
Women private portion self-cleaning function, highlights prevention gynecological inflammation effect.
Women privates nursing product is there is with liquid form in the hyaluronic acid private portion nursing gel of the present invention relative on market
Product can not only clean private portion, and moist nursing private portion that can be permanent and easy to use.
The preparation method of the hyaluronic acid private portion nursing gel of the present invention is according to the characteristic of every kind of component and prepares gel
Essential condition, carry out in homogenizer, use suitable temperature, rotating speed and time to complete, preparation method is simple and convenient！
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
The hyaluronic acid private portion nursing gel of the present invention, comprises the component of following mass percent, hyaluronic acid 0.5-
3.0%, plant extract 8.0-15.0%, glycyrrhizic acid dipotassium 0.1-0.2%, wetting agent 1.0-5.0%, filler 0.1-
0.5%, preservative 0.05-0.5%, thickening agent 1.0%-5.0%, PH regulator 0.1-1.0%, deionized water surplus, each group
Point mass percent summation is 100%, and hyaluronic acid has antiinflammatory bacteriostatic activity, and plant extract is camomile extract, green grass or young crops
Bur extract and Flos Chrysanthemi Indici extract arbitrary proportion compositions, wetting agent be alcohols, glycerol, hyaluronic acid any one or
Two or more mixture, wetting agent preferably glycerine, filler be sodium chloride or disodiumedetate any one, thickening
Agent is carbomer, hydroxyethyl cellulose, carbomer and the mixture of carboxymethyl cellulose arbitrary proportion, sodium alginate and carboxymethyl
The mixture of cellulose arbitrary proportion, chitosan and the mixture of carboxymethyl cellulose arbitrary proportion, sodium polyacrylate and propylene
At least one in the mixture of acid copolymer arbitrary proportion, PH regulator be lactic acid or citric acid or potassium hydroxide any one
Kind, PH regulator regulation pH value is 4.5-5.5, and the hyaluronic acid private portion nursing gel of the present invention selects appropriate mass percentage ratio
The viscosity of deionized water regulation gel.
For the hyaluronic acid private portion nursing gel of the explanation present invention have the most antibacterial and sterilization of safety, antiinflammatory, removing toxic substances, antiallergic,
Deodorization, can solve multiple gynecological inflammatory problems and improve slack vagina, recovers effect of vagina tight, to its effective one-tenth
The effect dividing hyaluronic acid, plant extract and glycyrrhizic acid dipotassium is explained with experiment in conjunction with the embodiments.
Embodiment one: illustrate that the hyaluronic acid private portion nursing gel of the present invention has the antibacterial and biocidal efficacies of safety
The hyaluronic acid private portion nursing gel of the present embodiment comprises the component of following mass percent: hyaluronic acid 1.0%,
Plant extract 15%, glycyrrhizic acid dipotassium 0.1%, wetting agent glycerol 1.5%, filler sodium chloride 0.2%, thickening agent carbomer
1.5%, preservative 0.1%, PH regulator potassium hydroxide 0.1%, surplus is deionized water, all components mass percent summation
Being 100%, wherein hyaluronic acid has anti-inflammatory activity, and plant extract includes camomile extract 5.0%, Princepia utilis extract
8.0% and Flos Chrysanthemi Indici extract 2.0%, in the present embodiment, deionized water is 100ml, and other component is joined according to mass percent
Ratio.
The hyaluronic acid private portion nursing gel preparation method of the present embodiment is as follows: hyaluronic acid, Flos Matricariae chamomillae are extracted by (1)
Thing, Princepia utilis extract, Flos Chrysanthemi Indici extract, glycyrrhizic acid dipotassium is sequentially added in deionized water and puts into homogenizer, at 25 DEG C
Process 20min with 1000rmp rotating speed, be completely dissolved to three, mix homogeneously；(2) wetting agent glycerol, filling then it are sequentially added into
Agent sodium chloride, preservative, in homogenizer, process 5min with 1000rmp rotating speed so that it is be completely dissolved at 25 DEG C, and mixing is all
Even；(3) add thickening agent carbomer in homogenizer, at 40 DEG C, process 100min with 800rmp rotating speed, make thickening agent complete
CL, mix homogeneously；(4) being eventually adding PH regulator potassium hydroxide, regulation PH is 4.5-5.5, makes gel.
Bacteriostasis and sterilization experiment and vaginal mucosa stimulation test is done respectively with the hyaluronic acid private portion nursing gel of the present embodiment
To verify that it has safe antibacterial and biocidal efficacies.
Bacteriostasis and sterilization is tested
Take Clinical isolation escherichia coli, staphylococcus aureus, bacillus pyocyaneus, Candida albicans a little, connect respectively
Plant in broth bouillon, its Pseudomonas aeruginosa broth bouillon adds the calf serum of 20%, at 37 DEG C, cultivate 18h.
Take the escherichia coli nutrient broth culture that 18h cultivates, be made into bacteria suspension for testing；Take sterilizing test tubes 11, the 1st
Adding escherichia coli nutrient broth fluid medium 9ml, 2-10 and prop up addition 5ml, the 11st adds 10ml, takes the present embodiment saturating
The women private portion nursing gel 1ml of bright matter acid adds the 1st test tube, takes 5ml and adds the 2nd, be diluted to successively after mix homogeneously
10th, the 11st is not added with sample as comparison；Every test tube adds escherichia coli suspension 0.1ml, cultivates at a temperature of 37 DEG C
24h, takes out and observes bacterial growth situation.As test tube becomes cloudy, i.e. representing bacterial growth, sample is without bacteriostasis；As test tube is clear
Bright, represent that bacterial growth is suppressed.Staphylococcus aureus, bacillus pyocyaneus, Candida albicans are with above-mentioned laboratory observation antibacterial
Growing state.Experimental result is as shown in table 1, illustrates that the present invention women private portion nursing gel containing hyaluronic acid is to clinical isolates
Strain escherichia coli, staphylococcus aureus, bacillus pyocyaneus, Candida albicans all have stronger bacteriostasis.
Each test tube bacterial growth situation in table 1 experiment
| C (escherichia coli) | C (staphylococcus aureus) | C (bacillus pyocyaneus) | C (Candida albicans) | |
| 1 | + | + | + | + |
| 2 | + | + | + | + |
| 3 | + | + | + | + |
| 4 | + | - | + | + |
| 5 | - | - | - | - |
| 6 | - | - | - | - |
| 7 | - | - | - | - |
| 8 | - | - | - | - |
| 9 | - | - | - | - |
| 10 | - | - | - | - |
| 11 | - | - | - | - |
Note: " " represents that test tube becomes cloudy；"+", represents that test tube is limpid.
Above-mentioned each strain test tube 1-4 is propped up the meat soup transferred species broth agar plates with matched group test tube, observes 24h, without thin
The Cmin of bacteria growing is bacteriocidal concentration, is designated as C, and unit is mg/mL, and result is as shown in table 2, illustrates that the present invention's is transparent
Clinical isolation escherichia coli, staphylococcus aureus, bacillus pyocyaneus, Candida albicans are all had by matter acid private portion nursing gel
Stronger bactericidal action.
Table 2 embodiment one sterilization conditions
| C (escherichia coli) | C (staphylococcus aureus) | C (bacillus pyocyaneus) | C (Candida albicans) | |
| Test tube one | 1.50 | 3.05 | 1.50 | 1.50 |
| Test tube two | 2.30 | 4.60 | 2.30 | 2.30 |
| Test tube three | 1.05 | 2.1 | 1.05 | 1.05 |
| Test tube four | 0.52 | 0.52 | 1.03 | 1.03 |
| Matched group | — | — | — | — |
Note: " " indicates without bactericidal properties.
Vaginal mucosa stimulation test
By the in " disinfection technology standard " (third edition) first fascicle " experimental technique specification " (Ministry of Public Health, 2012.4) the 3.5th
Test, choose healthy White Rabbit 6, be divided into experimental group 2, excipient group 2 and blank group 2.Experimental group: will
Experimental animal intravaginal inserted by the roundlet cotton sliver of the 2.0cm length scribbling the present embodiment test specimen；Excipient group: with onesize
Cotton sliver soak with sterile saline, insert animal intravaginal；Blank group: do not process.Removing cotton sliver after 4 hours, 24 hours
Rear execution animal, takes out topical vaginal tissue, observes with or without phenomenons such as hyperemia, edema.Experimental result is as shown in table 3, test group,
Excipient group, blank treated animal topical vaginal tissue all do not occur that erythema or edematous condition, irritant reaction integral mean value are
0.Sentence according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique specification " (Ministry of Public Health, 2012.4)
Fixed, the present invention is safe to healthy White Rabbit vaginal mucosa nonirritant, therefore combines above-mentioned bacteriostasis and sterilization description of test
Hyaluronic acid private portion of the present invention nursing gel has safe bacteriostasis and sterilization effect.
Table 3 sample vaginal mucosa stimulation test
| Symptom of erythema | Edematous condition | Irritant reaction integration | |
| Embodiment one | — | — | 0 |
| Excipient group | — | — | 0 |
| Blank group | — | — | 0 |
Note: " " indicates without erythema or edematous condition；" 0 " represents does not has vaginal irritation to react.
Embodiment two: illustrate that the hyaluronic acid private portion nursing gel of the present invention has antiinflammatory, removing toxic substances, antiallergic, deodorization solution
Multiple gynecological inflammatory problems and improve slack vagina, recovers effect of vagina tight
The hyaluronic acid private portion nursing gel of the present embodiment comprises the component of following mass percent: hyaluronic acid 1.0%,
Plant extract 10%, glycyrrhizic acid dipotassium 0.1%, wetting agent glycerol 1.5%, filler sodium chloride 0.2%, preservative 0.1%,
Thickening agent carbomer 1.5%, PH regulator potassium hydroxide 0.1%, surplus is deionized water, all components mass percent summation
Being 100%, wherein hyaluronic acid has antiinflammatory bacteriostatic activity, and plant extract includes that camomile extract 3.0%, Princepia utilis carry
Taking thing 6.0% and Flos Chrysanthemi Indici extract 1.0%, in the present embodiment, deionized water is 100ml, and other component is according to mass percent
Proportioning.
The hyaluronic acid private portion nursing gel preparation method of the present embodiment is as follows: hyaluronic acid, Flos Matricariae chamomillae are extracted by (1)
Thing, Princepia utilis extract, Flos Chrysanthemi Indici extract, glycyrrhizic acid dipotassium is sequentially added in deionized water and puts into homogenizer, at 25 DEG C
Process 20min with 1000rmp rotating speed, be completely dissolved to three, mix homogeneously；(2) wetting agent glycerol, filling then it are sequentially added into
Agent sodium chloride, preservative, in homogenizer, process 5min with 1000rmp rotating speed so that it is be completely dissolved at 25 DEG C, and mixing is all
Even；(3) add thickening agent carbomer in homogenizer, at 40 DEG C, process 100min with 800rmp rotating speed, make thickening agent complete
CL, mix homogeneously；(4) being eventually adding PH regulator potassium hydroxide, regulation PH is 4.5-5.5, makes gel.
With the hyaluronic acid private portion nursing gel of the present embodiment be respectively adopted human experimentation method validation its have antiinflammatory,
Removing toxic substances, antiallergic, deodorization, can solve multiple gynecological inflammatory problems and improve slack vagina, recovers effect of vagina tight,
Checking plant extract and the glycyrrhizic acid dipotassium synergism to hyaluronic acid simultaneously.
The all cases of this experiment are married middle age gynecological inflammation patient, and experimental group 1 uses the hyaluronic acid of the present embodiment
Private portion nursing gel (plant extract 10.0%+ glycyrrhizic acid dipotassium 0.1%+ hyaluronic acid 1.0%) is slept front with 1 time every night；Real
Test before group 2 employing plant extract 10.0%+ hyaluronic acid 1.0% women private portion nursing gel is slept every night with 1 time；Experimental group 3
With 1 time before using glycyrrhizic acid dipotassium 0.1%+ hyaluronic acid 1.0% women private portion nursing gel to sleep every night；Positive control uses
1.0% hyaluronic acid private portion nursing gel is slept front with 1 time every night；Negative control uses common woman private portion nursing gel to sleep every night
Front with 1 time；After comparison five groups is treated 7 days, symptom improves situation.
Private portion does not feel like oneself, relaxes, the symptom therapeutic evaluation such as pruritus, abnormal flavour:
Effective: symptom significantly improves or disappears, patient satisfaction；It is effective: symptom has improvement or alleviates, and patient still has discomfort,
Require continual cure；Invalid: symptom is without substantially alleviating, and patient is unsatisfied with.
Statistical method: use SPSS12.0 statistics software to carry out statistical procedures, compare between metering and enumeration data group
Relatively use t inspection and x2Inspection, with p < 0.05 for statistically significant difference.
Result is as follows:
As shown in table 4, the 8th day symptom improvement situation: effective 10 examples of experimental group 1, total effective rate 100%；Experimental group 2 is effective
1 example, effective 9 examples, total effective rate 100%, obvious effective rate compares P < 0.01 with experimental group 1；Effective 0 example of experimental group 3, effective 7 examples, nothing
Imitating 3 examples, total effective rate 70%, obvious effective rate compares P < 0.01 with experimental group 1；Effective 2 examples of positive control, effective 8 examples, total effective rate
100%, obvious effective rate compares p < 0.01 with experimental group 1.
The 8th day each group patients symptomatic of table 4 improves situation and compares
| Group | Sample number | Effective | Effectively | Invalid | Total effective rate (%) |
| Experimental group 1 | 10 | 10 | 0 | 0 | 100 |
| Experimental group 2 | 10 | 1 | 9 | 0 | 100 |
| Experimental group 3 | 10 | 0 | 7 | 3 | 70 |
| Positive control | 10 | 2 | 8 | 0 | 100 |
| Negative control | 10 | 0 | 0 | 10 | 0 |
Conclusion:
Experimental group 1 (plant extract 10.0%+ glycyrrhizic acid dipotassium 0.1%+ hyaluronic acid 1.0%) is substantially than experimental group 2
(plant extract 10.0%+ hyaluronic acid 1.0%), experimental group 3 (glycyrrhizic acid dipotassium 0.1%+ hyaluronic acid 1.0%), the positive
Comparison is effectively.Hyaluronic acid private portion nursing gel human experimentation of the present invention shows the hyaluronic acid private portion nursing of (1) present invention
Gel has antiinflammatory, removing toxic substances, antiallergic, deodorization solution multiple gynecological inflammatory problems and improves slack vagina, recovers vagina and compacts
Effect of state；(2) plant extract and glycyrrhizic acid dipotassium have the most collaborative work to the curative effect of hyaluronic acid treatment gynecological inflammation
With；(3) plant extract is notable to the synergism of hyaluronic acid relative to glycyrrhizic acid dipotassium.
Embodiment three: plant extract in the hyaluronic acid private portion nursing gel of the present invention, glycyrrhizic acid dipotassium and thoroughly are described
The proper ratio of bright matter acid
Above-mentioned experiment demonstrates hyaluronic acid, plant extract and the glycyrrhizic acid of hyaluronic acid private portion of the present invention nursing gel
Dipotassium compound prescription has sterilization, antibacterial, antiinflammatory, removing toxic substances, antiallergic, deodorization and improves slack vagina, recovers vagina and compacts shape
Effect of state, studies the appropriate proportioning of three kinds of components below.
Manufacture 8.0%, 10.0%, 15.0% plant extract, the glycyrrhizic acid dipotassium of 0.1%, 0.15%, 0.2% and
0.5%, the women private portion nursing gel of the hyaluronic acid compound prescription of 1.5%, 3.0%, quadrature factor table institute as shown in table 5
Show, suitably adjust wetting agent, filler, preservative, thickening agent, PH regulator and deionized water quality percentage ratio simultaneously.This reality
Testing all cases and be married middle age gynecological inflammation patient, 1-27 is with plant extract, glycyrrhizic acid dipotassium and hyaluronic acid in experiment
The women private portion nursing gel of variable concentrations sleep every night before with the orthogonal experiment carrying out Three factors-levels for 1 time；31 is negative right
With 1 treatment gynecological inflammation before sleeping every night according to using common private portion nursing gel, observe the situation after treatment；Positive control 28-
30 are respectively adopted before 0.5%, 1.5%, 3.0% hyaluronic acid stock solution gel is slept every night with 1 time, observe the situation after treatment；Often
Organizing 5 patients, comparison therapy is symptom improvement situation after 7 days.
Table 5 orthogonal experiment factor table
Private portion does not feel like oneself, relaxes, the symptom the standard of curative effect evaluation such as pruritus, abnormal flavour ibid.
Statistical method: use SPSS12.0 statistics software to carry out statistical procedures, compare between metering and enumeration data group
Relatively use t inspection and x2Inspection, with p < 0.05 for statistically significant difference.
Table 6 is respectively organized patients symptomatic on the 8th day and is improved situation
Conclusion:
Using experiment through human body, experimental result is as shown in table 6, uses the plant extract of 8.0%, 10.0%, 15.0%
Private with the women of the glycyrrhizic acid dipotassium of 0.1%, 0.15%, 0.2% and the hyaluronic acid compound prescription of 0.5%, 1.5%, 3.0%
Portion's nursing gel all has therapeutic effect to female gynecological inflammation and slack vagina, but does not limit to this scope.
Embodiment four: disclose hyaluronic acid private portion's nursing gel and the preparation method of several compound prescription, the present invention is described
Hyaluronic acid private portion nursing gel preparation method is simple.
Compound prescription one:
The component of the hyaluronic acid private portion nursing gel compound prescription one of the present invention is: hyaluronic acid 1.5%, plant extract
Thing 12.0%, glycyrrhizic acid dipotassium 0.1%, wetting agent glycerol 1.5%, filler disodiumedetate 0.2%, preservative
0.1%, thickening agent 1.1%, PH regulator potassium hydroxide 0.1%, surplus is deionized water, all components mass percent summation
Being 100%, wherein hyaluronic acid has antiinflammatory bacteriostatic activity, and plant extract includes that camomile extract 3.0%, Princepia utilis carry
Take thing 8.0% and Flos Chrysanthemi Indici extract 1.0%；Thickening agent includes that carbomer 0.4%, sodium polyacrylate 0.4% and acrylic acid are poly-
The mixture of compound 0.2% and hydroxyethyl cellulose 0.1%, in this compound prescription, deionized water is 100ml, other component according to
Mass percent proportioning.
The preparation method of the hyaluronic acid private portion nursing gel compound prescription one of the present invention, comprises the following steps: (1) will be thoroughly
Bright matter acid, camomile extract, Princepia utilis extract, Flos Chrysanthemi Indici extract, glycyrrhizic acid dipotassium are sequentially added in deionized water also
Put into homogenizer, at 40 DEG C, process 25min with 2000rmp rotating speed, be completely dissolved to three, mix homogeneously；(2) the most successively
Add in glycerol, sodium chloride, preservative to homogenizer, process 10min with 2000rmp rotating speed at 40 DEG C so that it is be completely dissolved, mixed
Close uniformly；(3) adding sodium polyacrylate and acrylate copolymer, hydroxyethyl cellulose, in carbomer to homogenizer, at 40 DEG C
Under with 500rmp rotating speed process 120min, make thickening agent be completely dissolved, mix homogeneously；(4) PH regulator hydroxide it is eventually adding
Potassium, regulation PH is 4.5-5.5, makes gel.
Compound prescription two:
The component of the hyaluronic acid private portion nursing gel compound prescription two of the present invention is: hyaluronic acid 2.0%, plant extract
Thing 13%, glycyrrhizic acid dipotassium 0.2%, wetting agent glycerol 1.5%, filler sodium chloride 0.2%, preservative 0.1%, thickening agent is
Carbomer 1.5% and the mixture of carboxymethyl cellulose 0.3%, PH regulator potassium hydroxide 0.1%, surplus is deionized water,
All components mass percent summation is 100%, and wherein hyaluronic acid has antiinflammatory bacteriostatic activity, and plant extract includes that ocean is sweet
Chrysanthemum extract 2.0%, Princepia utilis extract 10.0% and Flos Chrysanthemi Indici extract 1.0%, in this compound prescription, deionized water is
100ml, other component is according to mass percent proportioning.
The preparation method of the hyaluronic acid private portion nursing gel embodiment three of the present invention, comprises the following steps: (1) is by transparent
Matter acid, camomile extract, Princepia utilis extract, Flos Chrysanthemi Indici extract, glycyrrhizic acid dipotassium are sequentially added in deionized water and put
Enter homogenizer, at 50 DEG C, process 30min with 3000rmp rotating speed, be completely dissolved to three, mix homogeneously；(2) add the most successively
Enter in glycerol, sodium chloride, preservative to homogenizer, process 15min with 3000rmp rotating speed at 50 DEG C, make solution be completely dissolved, mixed
Close uniformly；(3) add poly-carboxymethyl cellulose, in carbomer to homogenizer, at 40 DEG C, process 100min with 800rmp rotating speed,
Thickening agent is made to be completely dissolved, mix homogeneously；(4) being eventually adding PH regulator potassium hydroxide, regulation PH is 4.5-5.5, makes solidifying
Glue.
Compound prescription three:
The component of the hyaluronic acid private portion nursing gel compound prescription three of the present invention is: hyaluronic acid 1.0%, plant extract
Thing 8.0%, glycyrrhizic acid dipotassium 0.1%, wetting agent glycerol 1.5%, filler sodium chloride 0.2%, preservative 0.1%, thickening agent
For sodium alginate 4.0% and carboxymethyl cellulose 0.3% mixture, PH regulator potassium hydroxide 0.1%, surplus is deionization
Water, all components mass percent summation is 100%, and wherein hyaluronic acid has antiinflammatory bacteriostatic activity, and plant extract includes
Camomile extract 1.0%, Princepia utilis extract 6.0% and Flos Chrysanthemi Indici extract 1.0%, in this compound prescription, deionized water is
100ml, other component is according to mass percent proportioning.
The preparation method of the hyaluronic acid private portion nursing gel embodiment three of the present invention, comprises the following steps: (1) is by transparent
Matter acid, camomile extract, Princepia utilis extract, Flos Chrysanthemi Indici extract, glycyrrhizic acid dipotassium are sequentially added in deionized water and put
Enter homogenizer, at 60 DEG C, process 30min with 5000rmp rotating speed, be completely dissolved to three, mix homogeneously；(2) add the most successively
Enter in glycerol, sodium chloride, preservative to homogenizer, process 20min with 5000rmp rotating speed at 60 DEG C, make solution be completely dissolved, mixed
Close uniformly；(3) add sodium alginate and carboxymethyl cellulose in homogenizer, process with 1000rmp rotating speed at 30 DEG C
120minn, makes thickening agent be completely dissolved, mix homogeneously；(4) being eventually adding potassium hydroxide, regulation PH is 4.5-5.5, makes solidifying
Glue.
The hyaluronic acid private portion nursing gel of the present invention is can be seen that from three above-mentioned compound prescriptions and preparation method
Each component of formula is sequentially placed in homogenizer by preparation method according to corresponding steps, select suitable temperature, rotating speed and time
Between can complete, simple and convenient！
Above-mentioned simply presently preferred embodiments of the present invention, not makees any pro forma restriction to the present invention.Although the present invention
Disclosed above with preferred embodiment, but it is not limited to the present invention.Any those of ordinary skill in the art, are not taking off
In the case of technical solution of the present invention scope, technical solution of the present invention is made perhaps by the technology contents that all may utilize the disclosure above
The most possible variation and modification, or it is revised as the Equivalent embodiments of equivalent variations.Therefore, every without departing from technical solution of the present invention
Content, according to the technology of the present invention essence to any simple modification made for any of the above embodiments, equivalent variations and modification, all should fall
In the range of technical solution of the present invention is protected.
Claims (8)
1. a hyaluronic acid private portion nursing gel, it is characterised in that: comprise the component of following mass percent,
Each constituent mass percentage ratio summation is 100%, and described hyaluronic acid has antiinflammatory bacteriostatic activity, and described plant extract is
The arbitrary proportion compositions of camomile extract, Princepia utilis extract and Flos Chrysanthemi Indici extract.
Hyaluronic acid private portion the most according to claim 1 nursing gel, it is characterised in that: described wetting agent is alcohols, sweet
Oil, any one or two or more mixture of hyaluronic acid.
Hyaluronic acid private portion the most according to claim 2 nursing gel, it is characterised in that: described wetting agent is glycerol.
Hyaluronic acid private portion the most according to claim 1 nursing gel, it is characterised in that: described filler be sodium chloride or
Disodiumedetate any one.
Hyaluronic acid private portion the most according to claim 1 nursing gel, it is characterised in that: described thickening agent be carbomer,
Hydroxyethyl cellulose, carbomer and the mixture of carboxymethyl cellulose arbitrary proportion, sodium alginate and carboxymethyl cellulose are any
The mixture of ratio, chitosan and the mixture of carboxymethyl cellulose arbitrary proportion, sodium polyacrylate and acrylic copolymer are appointed
At least one in the mixture of meaning ratio.
Hyaluronic acid private portion the most according to claim 1 nursing gel, it is characterised in that: described PH regulator be lactic acid or
Citric acid or potassium hydroxide any one.
Hyaluronic acid private portion the most according to claim 1 nursing gel, it is characterised in that: described PH regulator regulation pH value
For 4.5-5.5.
8. a preparation method for the hyaluronic acid private portion nursing gel described in claim 1, comprises the following steps that successively:
(1) hyaluronic acid, plant extract, glycyrrhizic acid dipotassium are sequentially added into deionized water, put in homogenizer, 20 DEG C-
At 60 DEG C, process 5min-30min with 500rmp-5000rmp rotating speed, be completely dissolved to three, mix homogeneously；
(2) the most successively wetting agent, filler and preservative are added in homogenizer, at 20 DEG C-60 DEG C, with 500rmp-
5000rmp rotating speed processes 5min-20min so that it is be completely dissolved, mix homogeneously；
(3) again thickening agent is added in homogenizer, at 20 DEG C-60 DEG C, process 30min-with 500rmp-5000rmp rotating speed
120min, makes thickening agent be completely dissolved, mix homogeneously；
(4) it is eventually adding PH regulator, regulates PH4.5-5.5, make gel.
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| CN201610850093.6A CN106309237A (en) | 2016-09-26 | 2016-09-26 | Hyaluronic acid private part care gel and preparation method thereof |
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| CN201610850093.6A CN106309237A (en) | 2016-09-26 | 2016-09-26 | Hyaluronic acid private part care gel and preparation method thereof |
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| CN107308104A (en) * | 2017-06-30 | 2017-11-03 | 江苏耐雀生物工程技术有限公司 | A kind of preparation method of gynecological gel |
| CN107789277A (en) * | 2017-10-27 | 2018-03-13 | 杭州惠博士生物科技有限公司 | A kind of hyaluronic acid lip composition and preparation method with multi-efficiency |
| CN108066278A (en) * | 2017-12-21 | 2018-05-25 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's gel containing chitosan oligosaccharide and preparation method thereof |
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| CN107308104A (en) * | 2017-06-30 | 2017-11-03 | 江苏耐雀生物工程技术有限公司 | A kind of preparation method of gynecological gel |
| CN107789277A (en) * | 2017-10-27 | 2018-03-13 | 杭州惠博士生物科技有限公司 | A kind of hyaluronic acid lip composition and preparation method with multi-efficiency |
| CN108066278A (en) * | 2017-12-21 | 2018-05-25 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's gel containing chitosan oligosaccharide and preparation method thereof |
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| CN108096169A (en) * | 2017-12-27 | 2018-06-01 | 广州昕生医学材料有限公司 | A kind of secret repairs gel |
| CN108096327A (en) * | 2017-12-29 | 2018-06-01 | 广州润虹医药科技股份有限公司 | A kind of Gynaecological suppository containing chitosan oligosaccharide and preparation method thereof |
| CN108144045A (en) * | 2017-12-29 | 2018-06-12 | 广州绿人生物科技有限公司 | A kind of biological agent for women and its application |
| CN108236715A (en) * | 2018-02-05 | 2018-07-03 | 苏伟鹏 | Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing |
| CN108478467A (en) * | 2018-03-05 | 2018-09-04 | 贵州泛特尔细胞生物技术有限公司 | A kind of toner and preparation method thereof |
| CN109381365A (en) * | 2018-12-29 | 2019-02-26 | 上海家化联合股份有限公司 | Thickener blend composition containing dipotassium glycyrrhizinate |
| CN110124017A (en) * | 2019-05-21 | 2019-08-16 | 张静 | A kind of bacteriostatic gel |
| CN112190541A (en) * | 2020-09-27 | 2021-01-08 | 安婕妤化妆品科技股份有限公司 | Privacy care gel product |
| CN112220737A (en) * | 2020-11-24 | 2021-01-15 | 广州市拓瑞科技有限公司 | Female private nursing gel and preparation method thereof |
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Application publication date: 20170111 |