CN105168676A - Female safety antimicrobial gel and preparation method thereof - Google Patents
Female safety antimicrobial gel and preparation method thereof Download PDFInfo
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- CN105168676A CN105168676A CN201510621099.1A CN201510621099A CN105168676A CN 105168676 A CN105168676 A CN 105168676A CN 201510621099 A CN201510621099 A CN 201510621099A CN 105168676 A CN105168676 A CN 105168676A
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Abstract
The invention discloses female safety antimicrobial gel. The female safety antimicrobial gel is prepared from materials A including, by weight, 0.1-1.5 parts of carbomer, 1-15 parts of polyethylene glycol and 68-96 parts of purified water, materials B including, by weight, 1-6 parts of tween 80, 0.05-1 part of aloe extract, 0.05-0.2 part of benzalkonium chloride, 0.05-2 parts of sodium hyaluronate and 0.1-1.5 parts of triethanolamine, and materials C including, by weight, 0.1-0.5 part of germall and 1-3.5 parts of octoxynol. The invention further discloses a preparation method of the female safety antimicrobial gel. The female safety antimicrobial gel can kill sperms, prevent pregnancy, conduct sterilization and disinfection and prevent reproductive tract infections, is small in vagina stimulation and has the two-way protection function.
Description
Technical field
The present invention relates to feminine care products, be specifically related to safe bacteriostatic gel of a kind of Ms and preparation method thereof.
Background technology
China is populous, and family planning is the fundamental state policy of China, develop safe, effective, easy to use, to human non-toxic's side effect, and have market popularization value and can mass-produced family planning product, have very important significance.At present conventional contraceptive device be rubber condom, oral contraceptive and external applied contraceptive three class be main.Condom at present uses more contraceptive device, but groups of people can occur allergy, break, the safety problem such as slippage in sexual intercourse.Oral contraceptive interference women estrogen excretory system, makes women not ovulate, thus reaches the object of contraception, but can cause the untoward reaction such as women's Nausea and vomiting.And existing external applied contraceptive is Western medicine, vagina and epithelium of cervix uteri may be caused to break, create chance to pathogenic microorganism invasion.
Therefore, need badly at present a kind of contraceptive effect safe and effective, prevention reproductive tract infection, to the safe bacteriostatic gel of the Ms that Vaginal irritation effects is little.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and/or defect, and the advantage will illustrated at least is below provided.
A further object of the invention is to provide the safe bacteriostatic gel of a kind of Ms, and it can anti-pregnancy by killing sperm, sterilizing, prevention reproductive tract infection, little to Vaginal irritation effects, has bidirectional protective effect.
A further object of the invention is to provide a kind of U-shaped extractor, and it can process simultaneously process respectively two kinds of Chinese crude drugs, and extract active substance in enclosed space, extraction efficiency is high, and intensive degree is high, to prepare the safe bacteriostatic gel of Ms.
In order to realize, according to these objects of the present invention and other advantage, providing the safe bacteriostatic gel of a kind of Ms, comprise the raw material of following weight portion:
A expects: carbomer 0.1 ~ 1.5 part, Polyethylene Glycol 1 ~ 15 part, pure water 68 ~ 96 parts;
B expects: Tween 80 1 ~ 6 part, Aloe extract 0.05 ~ 1 part, benzalkonium chloride 0.05 ~ 0.2 part, hyaluronate sodium 0.05 ~ 2 part, triethanolamine 0.1 ~ 1.5 part;
C expects: germall 0.1 ~ 0.5 part, Octoxinol 1 ~ 3.5 part.
Preferably, the safe bacteriostatic gel of described Ms, also comprise: D expects, it is: weight ratio be 18 ~ 20: 8 ~ 10: 3 ~ 5: 3 ~ 5: 3 ~ 5: 6 ~ 8: 6 ~ 8: 6 ~ 8: 4 Radix Sophorae Flavescentis, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, through extracting the Chinese medicine extract obtained, described Chinese medicine extract and described Octoxinol weight ratio are 1: 1.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 3 ~ 5min, stop after being warming up to 40 DEG C heating, insulated and stirred 1 ~ 1.5h, is warming up to 60 ~ 70 DEG C, insulated and stirred 20min, add Polyethylene Glycol, insulated and stirred 15min, be cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, 20min is stirred under vacuum condition, add triethanolamine, stir 5min, be cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under vacuum condition to the emulsifying pot in step 2,100 order monolayer filter-cloth filterings, to obtain final product.
Preferably, the preparation method of the safe bacteriostatic gel of described Ms, also comprises:
Step 4, one U-shaped extractor is provided, it comprises the first hollow box body that side is cuboid, 3rd hollow box body of opposite side to be the second hollow box body of cuboid and bottom be arc column, the top of described first hollow box body and described second hollow box body is provided with can the first lid of On/Off, described first hollow box body is connected with nitrogen cylinder with the top of described second hollow box body, the bottom of described first hollow box body and described second hollow box body is provided with screen cloth and slide valve successively, the top of described 3rd hollow box body is provided with can the second lid of On/Off, described first hollow box body and described second hollow box body external rings are provided with the first electric heating tube, and the bottom of described 3rd hollow box body is provided with the second electric heating tube,
Step 5, get the Radix Sophorae Flavescentis that weight ratio is 18 ~ 20: 8 ~ 10: 3 ~ 5: 3 ~ 5: 3 ~ 5: 6 ~ 8: 6 ~ 8: 6 ~ 8: 4, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, by the Radix Sophorae Flavescentis of above-mentioned weight ratio, Rhizoma Sparganii, Fructus Hippophae, Rhizoma Polygonati, celery seed and Radix Asparagi are placed in described first hollow box body, and close the first lid being positioned at top, by the Herba Dendrobii of above-mentioned parts by weight, Herba Leonuri and Herba Ecliptae are placed in described second hollow box body, and close the first lid being positioned at top, ethanol is placed in described 3rd hollow box body, and close described second lid, open the slide valve be positioned at below screen cloth, make described first hollow box body, described second hollow box body is communicated with described 3rd hollow box body, but material does not wherein contact with each other, start described second electric heating tube, heating the third hollow box body described is to the whole evaporate to dryness of ethanol, nitrogen is passed in described U-shaped extractor, keep 1 ~ 2h, return back to atmospheric pressure,
Step 6, close the slide valve be positioned at below screen cloth, make described first hollow box body, described second hollow box body is not communicated with described 3rd hollow box body, deionized water is passed in described first hollow box body and described second hollow box body, liquid level is made to exceed the surface of the material of described first hollow box body and described second hollow box body inside, close the first lid being positioned at top, start described first electric heating tube, first hollow box body described in electrical heating and described second hollow box body, to the surface of liquid level lower than the material of described first hollow box body and described second hollow box body inside, open described slide valve, medicinal liquid after filtering is imported described 3rd hollow box body, repeat 2 ~ 3 times, the medicinal liquid that described 3rd hollow box body is collected is derived,
Step 7, medicinal liquid 100 order monolayer filter-cloth filterings step 6 obtained, after radiation sterilizing, be to mix at 1: 1 with the Octoxinol in step 3 according to mass ratio, stir 30min, obtain the safe bacteriostatic gel of described Ms under vacuum condition.
Preferably, the preparation method of the safe bacteriostatic gel of described Ms, the vacuum condition in step 2, step 3 and step 7 is-0.08 ~-0.06MPa.
Preferably, the preparation method of the safe bacteriostatic gel of described Ms, in step 5, the temperature of the third hollow box body described in electrical heating is 70 ~ 75 DEG C, in step 6, and the temperature of the first hollow box body described in electrical heating and described second hollow box body is 95 ~ 98 DEG C.
Preferably, the preparation method of the safe bacteriostatic gel of described Ms, in step 5, the pressure passing into nitrogen in described U-shaped extractor is 2 ~ 3MPa.
Preferably, the preparation method of the safe bacteriostatic gel of described Ms, the rotating speed of the stirring in step one, step 2, step 3 and step 7 is 900r/min.
Preferably, the preparation method of the safe bacteriostatic gel of described Ms, described screen cloth is provided with 1 × 1mm squared mesh.
The present invention at least comprises following beneficial effect:
The first, benzalkonium chloride is wide-spectrum bactericide, and Octoxinol is spermicide, and Aloe has the effect of antiinflammatory, can also strengthen phagocytosis, removing toxic substances and cleaning function, and collocation use can spermicidal and all kinds of sexually transmitted disease (STD) cause of disease fast; The basis of above formula is added the Chinese medicine extract that multiple Chinese medicinal components is obtained, heat-clearing and toxic substances removing on the one hand, avoid and suppress Octoxinol to the side effect of human body, on the other hand, the generation of effective suppression privates antibacterial, safe spermicidal, avoids the stimulation to male genital organ and vagina, form moist, healthy local environment, antibacterial, antiviral, raising immunity of organisms; Preparation method of the present invention is simple and convenient, strictly sterilizes to each process cleaning by factory's cleaning and sterilizing technique;
The second, Radix Sophorae Flavescentis, Rhizoma Sparganii, Herba Leonuri, Radix Asparagi and celery seed have size degradation sperm, make the function of external sperm moment inactivation; Fructus Hippophae, Rhizoma Polygonati, Herba Dendrobii and Herba Ecliptae have heat clearing and damp drying, the function of skin, tranquilizing by nourishing the heart of releiving of invigorating blood circulation, each taste Chinese medicine monarch, and spermicidal sterilizes, and privates of releiving skin, avoids the diseases such as urinary tract infection;
3rd, the invention provides a kind of U-shaped extractor, pretreatment is carried out to Chinese medicine, by being separated into three independently casings, when opening slide valve, the material being positioned at the first hollow box body and the second hollow box body is positioned at above screen cloth, do not contact with the ethanol of the 3rd hollow box body, steam ethanol to all volatilizations, penetrate into medical material inside, sterilization is stripping active substance also, by applying high-pressure inert gas, promote the stripping of active substance, when closing slide valve, the material being positioned at the first hollow box body and the second hollow box body decocts, then slide valve is opened, export to the 3rd hollow box body, merge medicinal liquid repeatedly, obtain Chinese medicine extract,
Four, the present invention is according to physical factors such as Chinese medicine form, hardness, Chinese medicine is divided into two groups, throws in into the first hollow box body and the second hollow box body respectively, carry out successively steaming, suppress and decocting at seal cavity, active substance dissolution is maximized; Vacuumizing has froth breaking effect; Step 5, electricity heating degree 70 ~ 75 DEG C, reaches the boiling point of ethanol, makes whole evaporation, and to steam Chinese crude drug, in step 6, electrical heating temperature is 95 ~ 98 DEG C, and high temperature makes deionized water seethe with excitement, with decocting herb material; In step 5, pressure is 2 ~ 3MPa, promotes the stripping of active substance; Mesh size, prevents Chinese crude drug from entering the 3rd hollow box body.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Accompanying drawing explanation
Fig. 1 is the structural representation of U-shaped extractor of the present invention.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
< embodiment 1>
The safe bacteriostatic gel of a kind of Ms, comprises the raw material of following weight portion:
A expects: carbomer 0.1 part, Polyethylene Glycol 1 part, pure water 68 parts;
B expects: Tween 80 1 part, Aloe extract 0.05 part, benzalkonium chloride 0.05 part, hyaluronate sodium 0.05 part, triethanolamine 0.1 part;
C expects: germall 0.1 part, Octoxinol 1 part.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 3min, stop after being warming up to 40 DEG C heating, insulated and stirred 1h, is warming up to 60 DEG C, insulated and stirred 20min, adds Polyethylene Glycol, insulated and stirred 15min, rotating speed is 900r/min, is cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, under-0.08MPa, stir 20min, rotating speed is 900r/min, add triethanolamine, stir 5min, rotating speed is 900r/min, is cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under-0.08MPa to the emulsifying pot in step 2, rotating speed is 900r/min, and 100 order monolayer filter-cloth filterings, to obtain final product.
< embodiment 2>
The safe bacteriostatic gel of a kind of Ms, comprises the raw material of following weight portion:
A expects: carbomer 1.5 parts, Polyethylene Glycol 15 parts, pure water 96 parts;
B expects: Tween 80 6 parts, Aloe extract 1 part, benzalkonium chloride 0.2 part, hyaluronate sodium 2 parts, triethanolamine 1.5 parts;
C expects: germall 0.5 part, Octoxinol 3.5 parts.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 5min, stop after being warming up to 40 DEG C heating, insulated and stirred 1.5h, is warming up to 70 DEG C, insulated and stirred 20min, adds Polyethylene Glycol, insulated and stirred 15min, rotating speed is 900r/min, is cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, under-0.06MPa, stir 20min, rotating speed is 900r/min, add triethanolamine, stir 5min, rotating speed is 900r/min, is cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under-0.06MPa to the emulsifying pot in step 2, rotating speed is 900r/min, and 100 order monolayer filter-cloth filterings, to obtain final product.
< embodiment 3>
The safe bacteriostatic gel of a kind of Ms, comprises the raw material of following weight portion:
A expects: carbomer 1 part, Polyethylene Glycol 8 parts, pure water 82 parts;
B expects: Tween 80 4 parts, Aloe extract 0.5 part, benzalkonium chloride 0.12 part, hyaluronate sodium 1 part, triethanolamine 0.8 part;
C expects: germall 0.3 part, Octoxinol 2.5 parts.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 4min, stop after being warming up to 40 DEG C heating, insulated and stirred 1h, is warming up to 65 DEG C, insulated and stirred 20min, adds Polyethylene Glycol, insulated and stirred 15min, rotating speed is 900r/min, is cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, under-0.07MPa, stir 20min, rotating speed is 900r/min, add triethanolamine, stir 5min, rotating speed is 900r/min, is cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under-0.07MPa to the emulsifying pot in step 2, rotating speed is 900r/min, and 100 order monolayer filter-cloth filterings, to obtain final product.
< embodiment 4>
The safe bacteriostatic gel of a kind of Ms, comprises the raw material of following weight portion:
A expects: carbomer 0.1 part, Polyethylene Glycol 1 part, pure water 68 parts;
B expects: Tween 80 1 part, Aloe extract 0.05 part, benzalkonium chloride 0.05 part, hyaluronate sodium 0.05 part, triethanolamine 0.1 part;
C expects: germall 0.1 part, Octoxinol 1 part;
D expects: its for weight ratio be 18: 8: 3: 3: 3: 6: 6: 6: 4 Radix Sophorae Flavescentis, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, through extracting the Chinese medicine extract obtained, described Chinese medicine extract and described Octoxinol weight ratio are 1: 1.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 3min, stop after being warming up to 40 DEG C heating, insulated and stirred 1h, is warming up to 60 DEG C, insulated and stirred 20min, adds Polyethylene Glycol, insulated and stirred 15min, rotating speed is 900r/min, is cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, under-0.08MPa, stir 20min, rotating speed is 900r/min, add triethanolamine, stir 5min, rotating speed is 900r/min, is cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under-0.08MPa to the emulsifying pot in step 2, rotating speed is 900r/min, and 100 order monolayer filter-cloth filterings, to obtain final product;
Step 4, one U-shaped extractor is provided, it comprises the first hollow box body 1 that side is cuboid, 3rd hollow box body 3 of opposite side to be the second hollow box body 2 of cuboid and bottom be arc column, the top of described first hollow box body 1 and described second hollow box body 2 is provided with can the first lid 4 of On/Off, described first hollow box body 1 is connected with nitrogen cylinder 5 with the top of described second hollow box body 2, the bottom of described first hollow box body 1 and described second hollow box body 2 is provided with screen cloth 6 and slide valve 7 successively, described screen cloth 6 is provided with 1 × 1mm squared mesh, the top of described 3rd hollow box body 3 is provided with can the second lid 8 of On/Off, described first hollow box body 1 and described second hollow box body 2 external rings are provided with the first electric heating tube 9, and the bottom of described 3rd hollow box body 3 is provided with the second electric heating tube 10,
Step 5, get the Radix Sophorae Flavescentis that weight ratio is 18: 8: 3: 3: 3: 6: 6: 6: 4, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, by the Radix Sophorae Flavescentis of above-mentioned weight ratio, Rhizoma Sparganii, Fructus Hippophae, Rhizoma Polygonati, celery seed and Radix Asparagi are placed in described first hollow box body 1, and close the first lid 4 being positioned at top, by the Herba Dendrobii of above-mentioned parts by weight, Herba Leonuri and Herba Ecliptae are placed in described second hollow box body 2, and close the first lid 4 being positioned at top, ethanol are placed in described 3rd hollow box body 3, and close described second lid 8, open the slide valve 7 be positioned at below screen cloth 6, make described first hollow box body 1, described second hollow box body 2 is communicated with described 3rd hollow box body 3, but material does not wherein contact with each other, start described second electric heating tube 10, the temperature of the third hollow box body described in electrical heating is 70 DEG C, heating the third hollow box body described is to the whole evaporate to dryness of ethanol, and in described U-shaped extractor, pass into nitrogen, pressure is 2MPa, keep 1h, return back to atmospheric pressure,
Step 6, close the slide valve 7 be positioned at below screen cloth 6, make described first hollow box body 1, described second hollow box body 2 is not communicated with described 3rd hollow box body 3, deionized water is passed in described first hollow box body 1 and described second hollow box body 2, liquid level is made to exceed the surface of the material of described first hollow box body 1 and described second hollow box body 2 inside, close the first lid 4 being positioned at top, start described first electric heating tube 9, the temperature of the first hollow box body 1 described in electrical heating and described second hollow box body 2 is 95 DEG C, to the surface of liquid level lower than the material of described first hollow box body 1 and described second hollow box body 2 inside, open described slide valve 7, medicinal liquid after filtering is imported described 3rd hollow box body 3, repeat 2 times, the medicinal liquid collected by described 3rd hollow box body 3 is derived,
Step 7, the medicinal liquid 100 order monolayer filter-cloth filterings that step 6 is obtained, after radiation sterilizing, be to mix at 1: 1 with the Octoxinol in step 3 according to mass ratio, under-0.08MPa, stir 30min, rotating speed is 900r/min, obtains the safe bacteriostatic gel of described Ms.
< embodiment 5>
The safe bacteriostatic gel of a kind of Ms, comprises the raw material of following weight portion:
A expects: carbomer 1.5 parts, Polyethylene Glycol 15 parts, pure water 96 parts;
B expects: Tween 80 6 parts, Aloe extract 1 part, benzalkonium chloride 0.2 part, hyaluronate sodium 2 parts, triethanolamine 1.5 parts;
C expects: germall 0.5 part, Octoxinol 3.5 parts;
D expects: its for weight ratio be 20: 10: 5: 5: 5: 8: 8: 8: 4 Radix Sophorae Flavescentis, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, through extracting the Chinese medicine extract obtained, described Chinese medicine extract and described Octoxinol weight ratio are 1: 1.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 5min, stop after being warming up to 40 DEG C heating, insulated and stirred 1.5h, is warming up to 70 DEG C, insulated and stirred 20min, adds Polyethylene Glycol, insulated and stirred 15min, rotating speed is 900r/min, is cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, under-0.06MPa, stir 20min, rotating speed is 900r/min, add triethanolamine, stir 5min, rotating speed is 900r/min, is cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under-0.06MPa to the emulsifying pot in step 2, rotating speed is 900r/min, and 100 order monolayer filter-cloth filterings, to obtain final product;
Step 4, one U-shaped extractor is provided, it comprises the first hollow box body 1 that side is cuboid, 3rd hollow box body 3 of opposite side to be the second hollow box body 2 of cuboid and bottom be arc column, the top of described first hollow box body 1 and described second hollow box body 2 is provided with can the first lid 4 of On/Off, described first hollow box body 1 is connected with nitrogen cylinder 5 with the top of described second hollow box body 2, the bottom of described first hollow box body 1 and described second hollow box body 2 is provided with screen cloth 6 and slide valve 7 successively, described screen cloth 6 is provided with 1 × 1mm squared mesh, the top of described 3rd hollow box body 3 is provided with can the second lid 8 of On/Off, described first hollow box body 1 and described second hollow box body 2 external rings are provided with the first electric heating tube 9, and the bottom of described 3rd hollow box body 3 is provided with the second electric heating tube 10,
Step 5, get the Radix Sophorae Flavescentis that weight ratio is 20: 10: 5: 5: 5: 8: 8: 8: 4, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, by the Radix Sophorae Flavescentis of above-mentioned weight ratio, Rhizoma Sparganii, Fructus Hippophae, Rhizoma Polygonati, celery seed and Radix Asparagi are placed in described first hollow box body 1, and close the first lid 4 being positioned at top, by the Herba Dendrobii of above-mentioned parts by weight, Herba Leonuri and Herba Ecliptae are placed in described second hollow box body 2, and close the first lid 4 being positioned at top, ethanol are placed in described 3rd hollow box body 3, and close described second lid 8, open the slide valve 7 be positioned at below screen cloth 6, make described first hollow box body 1, described second hollow box body 2 is communicated with described 3rd hollow box body 3, but material does not wherein contact with each other, start described second electric heating tube 10, the temperature of the third hollow box body described in electrical heating is 75 DEG C, heating the third hollow box body described is to the whole evaporate to dryness of ethanol, and in described U-shaped extractor, pass into nitrogen, pressure is 3MPa, keep 2h, return back to atmospheric pressure,
Step 6, close the slide valve 7 be positioned at below screen cloth 6, make described first hollow box body 1, described second hollow box body 2 is not communicated with described 3rd hollow box body 3, deionized water is passed in described first hollow box body 1 and described second hollow box body 2, liquid level is made to exceed the surface of the material of described first hollow box body 1 and described second hollow box body 2 inside, close the first lid 4 being positioned at top, start described first electric heating tube 9, the temperature of the first hollow box body 1 described in electrical heating and described second hollow box body 2 is 98 DEG C, to the surface of liquid level lower than the material of described first hollow box body 1 and described second hollow box body 2 inside, open described slide valve 7, medicinal liquid after filtering is imported described 3rd hollow box body 3, repeat 3 times, the medicinal liquid collected by described 3rd hollow box body 3 is derived,
Step 7, the medicinal liquid 100 order monolayer filter-cloth filterings that step 6 is obtained, after radiation sterilizing, be to mix at 1: 1 with the Octoxinol in step 3 according to mass ratio, under-0.06MPa, stir 30min, rotating speed is 900r/min, obtains the safe bacteriostatic gel of described Ms.
< embodiment 6>
The safe bacteriostatic gel of a kind of Ms, comprises the raw material of following weight portion:
A expects: carbomer 1 part, Polyethylene Glycol 8 parts, pure water 82 parts;
B expects: Tween 80 4 parts, Aloe extract 0.5 part, benzalkonium chloride 0.12 part, hyaluronate sodium 1 part, triethanolamine 0.8 part;
C expects: germall 0.3 part, Octoxinol 2.5 parts;
D expects: its for weight ratio be 19: 9: 4: 4: 4: 7: 7: 7: 4 Radix Sophorae Flavescentis, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, through extracting the Chinese medicine extract obtained, described Chinese medicine extract and described Octoxinol weight ratio are 1: 1.
A preparation method for the safe bacteriostatic gel of Ms, comprises the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 4min, stop after being warming up to 40 DEG C heating, insulated and stirred 1h, is warming up to 65 DEG C, insulated and stirred 20min, adds Polyethylene Glycol, insulated and stirred 15min, rotating speed is 900r/min, is cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, under-0.07MPa, stir 20min, rotating speed is 900r/min, add triethanolamine, stir 5min, rotating speed is 900r/min, is cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under-0.07MPa to the emulsifying pot in step 2, rotating speed is 900r/min, and 100 order monolayer filter-cloth filterings, to obtain final product;
Step 4, one U-shaped extractor is provided, it comprises the first hollow box body 1 that side is cuboid, 3rd hollow box body 3 of opposite side to be the second hollow box body 2 of cuboid and bottom be arc column, the top of described first hollow box body 1 and described second hollow box body 2 is provided with can the first lid 4 of On/Off, described first hollow box body 1 is connected with nitrogen cylinder 5 with the top of described second hollow box body 2, the bottom of described first hollow box body 1 and described second hollow box body 2 is provided with screen cloth 6 and slide valve 7 successively, described screen cloth 6 is provided with 1 × 1mm squared mesh, the top of described 3rd hollow box body 3 is provided with can the second lid 8 of On/Off, described first hollow box body 1 and described second hollow box body 2 external rings are provided with the first electric heating tube 9, and the bottom of described 3rd hollow box body 3 is provided with the second electric heating tube 10,
Step 5, get the Radix Sophorae Flavescentis that weight ratio is 19: 9: 4: 4: 4: 7: 7: 7: 4, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, by the Radix Sophorae Flavescentis of above-mentioned weight ratio, Rhizoma Sparganii, Fructus Hippophae, Rhizoma Polygonati, celery seed and Radix Asparagi are placed in described first hollow box body 1, and close the first lid 4 being positioned at top, by the Herba Dendrobii of above-mentioned parts by weight, Herba Leonuri and Herba Ecliptae are placed in described second hollow box body 2, and close the first lid 4 being positioned at top, ethanol are placed in described 3rd hollow box body 3, and close described second lid 8, open the slide valve 7 be positioned at below screen cloth 6, make described first hollow box body 1, described second hollow box body 2 is communicated with described 3rd hollow box body 3, but material does not wherein contact with each other, start described second electric heating tube 10, the temperature of the third hollow box body described in electrical heating is 72 DEG C, heating the third hollow box body described is to the whole evaporate to dryness of ethanol, and in described U-shaped extractor, pass into nitrogen, pressure is 2.5MPa, keep 1.5h, return back to atmospheric pressure,
Step 6, close the slide valve 7 be positioned at below screen cloth 6, make described first hollow box body 1, described second hollow box body 2 is not communicated with described 3rd hollow box body 3, deionized water is passed in described first hollow box body 1 and described second hollow box body 2, liquid level is made to exceed the surface of the material of described first hollow box body 1 and described second hollow box body 2 inside, close the first lid 4 being positioned at top, start described first electric heating tube 9, the temperature of the first hollow box body 1 described in electrical heating and described second hollow box body 2 is 97 DEG C, to the surface of liquid level lower than the material of described first hollow box body 1 and described second hollow box body 2 inside, open described slide valve 7, medicinal liquid after filtering is imported described 3rd hollow box body 3, repeat 3 times, the medicinal liquid collected by described 3rd hollow box body 3 is derived,
Step 7, the medicinal liquid 100 order monolayer filter-cloth filterings that step 6 is obtained, after radiation sterilizing, be to mix at 1: 1 with the Octoxinol in step 3 according to mass ratio, under-0.07MPa, stir 30min, rotating speed is 900r/min, obtains the safe bacteriostatic gel of described Ms.
< antibacterial experiment in vitro >
Get Clinical isolation staphylococcus aureus, Candida albicans and B-mode micrococcus scarlatinae, be incubated at respectively in culture medium, the safe bacteriostatic gel that Example 1 ~ 6 obtains makes experimental example, get certain gynaecologic washing lotion commercially available to do ratio, adopt test tube method to measure minimum inhibitory concentration, experimental result is as follows:
As seen from the above table, embodiment 1 ~ 6 pair of staphylococcus aureus, Candida albicans and B-mode micrococcus scarlatinae all have stronger bacteriostasis, and wherein the minimum inhibitory concentration of embodiment 4 ~ 6 is minimum, illustrate that in-vitro antibacterial effect is best.
< animal contraception experiment >
Get male rabbit 20 and the female rabbit ten of fertility, every doe copulation first 24 hours intramuscular injection estradiol benzoate 0.1mg that oestrus promote the sexual maturity, the Ms that Example 6 obtains is safe, and bacteriostatic gel makes experimental example, during experiment, gel is pushed doe vagina, after 10min, by 1: 2, doe and male rabbit are carried out copulation, copulation dissected doe after 30 days, all without stillborn fetus, unpregnancy doe is 10, and contraceptive prevalence rate reaches 100%.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend described.
Claims (9)
1. the safe bacteriostatic gel of Ms, is characterized in that, comprises the raw material of following weight portion:
A expects: carbomer 0.1 ~ 1.5 part, Polyethylene Glycol 1 ~ 15 part, pure water 68 ~ 96 parts;
B expects: Tween 80 1 ~ 6 part, Aloe extract 0.05 ~ 1 part, benzalkonium chloride 0.05 ~ 0.2 part, hyaluronate sodium 0.05 ~ 2 part, triethanolamine 0.1 ~ 1.5 part;
C expects: germall 0.1 ~ 0.5 part, Octoxinol 1 ~ 3.5 part.
2. the safe bacteriostatic gel of Ms as claimed in claim 1, it is characterized in that, also comprise: D expects, it is: weight ratio be 18 ~ 20: 8 ~ 10: 3 ~ 5: 3 ~ 5: 3 ~ 5: 6 ~ 8: 6 ~ 8: 6 ~ 8: 4 Radix Sophorae Flavescentis, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, through extracting the Chinese medicine extract obtained, described Chinese medicine extract and described Octoxinol weight ratio are 1: 1.
3. a preparation method for the safe bacteriostatic gel of Ms as claimed in claim 1, is characterized in that, comprise the following steps:
Step one, A is expected in the pure water of 2/3 amount add emulsifying pot, slowly add carbomer, stir 3 ~ 5min, stop after being warming up to 40 DEG C heating, insulated and stirred 1 ~ 1.5h, is warming up to 60 ~ 70 DEG C, insulated and stirred 20min, add Polyethylene Glycol, insulated and stirred 15min, be cooled to 55 DEG C;
Step 2, in advance with A material in pure water by B expect in hyaluronate sodium just swelling, emulsifying pot in step one adds Tween 80, insulated and stirred 10min, add Aloe extract, benzalkonium chloride and swelling good hyaluronate sodium in advance, 20min is stirred under vacuum condition, add triethanolamine, stir 5min, be cooled to 45 DEG C;
Step 3, dissolve the germall in C material with remaining pure water in A material in advance, add the germall that dissolved and Octoxinol stirs 30min under vacuum condition to the emulsifying pot in step 2,100 order monolayer filter-cloth filterings, to obtain final product.
4. the preparation method of the safe bacteriostatic gel of Ms as claimed in claim 3, is characterized in that, also comprise:
Step 4, one U-shaped extractor is provided, it comprises the first hollow box body that side is cuboid, 3rd hollow box body of opposite side to be the second hollow box body of cuboid and bottom be arc column, the top of described first hollow box body and described second hollow box body is provided with can the first lid of On/Off, described first hollow box body is connected with nitrogen cylinder with the top of described second hollow box body, the bottom of described first hollow box body and described second hollow box body is provided with screen cloth and slide valve successively, the top of described 3rd hollow box body is provided with can the second lid of On/Off, described first hollow box body and described second hollow box body external rings are provided with the first electric heating tube, and the bottom of described 3rd hollow box body is provided with the second electric heating tube,
Step 5, get the Radix Sophorae Flavescentis that weight ratio is 18 ~ 20: 8 ~ 10: 3 ~ 5: 3 ~ 5: 3 ~ 5: 6 ~ 8: 6 ~ 8: 6 ~ 8: 4, Fructus Hippophae, Rhizoma Sparganii, Herba Leonuri, Rhizoma Polygonati, Radix Asparagi, Herba Dendrobii, celery seed and Herba Ecliptae, by the Radix Sophorae Flavescentis of above-mentioned weight ratio, Rhizoma Sparganii, Fructus Hippophae, Rhizoma Polygonati, celery seed and Radix Asparagi are placed in described first hollow box body, and close the first lid being positioned at top, by the Herba Dendrobii of above-mentioned parts by weight, Herba Leonuri and Herba Ecliptae are placed in described second hollow box body, and close the first lid being positioned at top, ethanol is placed in described 3rd hollow box body, and close described second lid, open the slide valve be positioned at below screen cloth, make described first hollow box body, described second hollow box body is communicated with described 3rd hollow box body, but material does not wherein contact with each other, start described second electric heating tube, heating the third hollow box body described is to the whole evaporate to dryness of ethanol, nitrogen is passed in described U-shaped extractor, keep 1 ~ 2h, return back to atmospheric pressure,
Step 6, close the slide valve be positioned at below screen cloth, make described first hollow box body, described second hollow box body is not communicated with described 3rd hollow box body, deionized water is passed in described first hollow box body and described second hollow box body, liquid level is made to exceed the surface of the material of described first hollow box body and described second hollow box body inside, close the first lid being positioned at top, start described first electric heating tube, first hollow box body described in electrical heating and described second hollow box body, to the surface of liquid level lower than the material of described first hollow box body and described second hollow box body inside, open described slide valve, medicinal liquid after filtering is imported described 3rd hollow box body, repeat 2 ~ 3 times, the medicinal liquid that described 3rd hollow box body is collected is derived,
Step 7, medicinal liquid 100 order monolayer filter-cloth filterings step 6 obtained, after radiation sterilizing, be to mix at 1: 1 with the Octoxinol in step 3 according to mass ratio, stir 30min, obtain the safe bacteriostatic gel of described Ms under vacuum condition.
5. the preparation method of the safe bacteriostatic gel of Ms as claimed in claim 4, it is characterized in that, the vacuum condition in step 2, step 3 and step 7 is-0.08 ~-0.06MPa.
6. the preparation method of the safe bacteriostatic gel of Ms as claimed in claim 5, it is characterized in that, in step 5, the temperature of the third hollow box body described in electrical heating is 70 ~ 75 DEG C, in step 6, the temperature of the first hollow box body described in electrical heating and described second hollow box body is 95 ~ 98 DEG C.
7. the preparation method of the safe bacteriostatic gel of Ms as claimed in claim 6, it is characterized in that, in step 5, the pressure passing into nitrogen in described U-shaped extractor is 2 ~ 3MPa.
8. the preparation method of the safe bacteriostatic gel of Ms as claimed in claim 7, it is characterized in that, the rotating speed of the stirring in step one, step 2, step 3 and step 7 is 900r/min.
9. the preparation method of the safe bacteriostatic gel of Ms as claimed in claim 8, it is characterized in that, described screen cloth is provided with 1 × 1mm squared mesh.
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