CN111419932A

CN111419932A - Composition with dual functions of bacteriostasis and nursing for male private parts and preparation method thereof

Info

Publication number: CN111419932A
Application number: CN202010303894.7A
Authority: CN
Inventors: 郭凯
Original assignee: Chengdu Qianlutong Biotechnology Co ltd
Current assignee: Chengdu Qianlutong Biotechnology Co ltd
Priority date: 2020-04-21
Filing date: 2020-04-21
Publication date: 2020-07-17

Abstract

The invention discloses a composition with dual functions of bacteriostasis and nursing for male private parts and a preparation method thereof. The composition has the functions of bacteriostasis, relieving itching, fragrance, comfort and removing peculiar smell, is used for cleaning male private parts, daily nursing and nursing before and after sexual life, can treat scrotal dampness, scrotal eczema and neurodermatitis, improves the male premature ejaculation state, enhances the male sexual function and the like. The invention also discloses a preparation method of the composition, which is prepared by pretreating the traditional Chinese medicines respectively by solvent extraction and the like according to different characteristics of the traditional Chinese medicines and then preparing the traditional Chinese medicines in proportion.

Description

Composition with dual functions of bacteriostasis and nursing for male private parts and preparation method thereof

Technical Field

The invention relates to a composition with dual functions of bacteriostasis and nursing for male private parts and a preparation method thereof. The invention particularly relates to a preparation prepared from fructus cnidii, clove, pepper, cinnamon, cynomorium songaricum, nidus vespae, borneol, menthol and the like serving as main raw materials, and a preparation method of the composition.

Background

With the progress of modern society, the pressure faced by male friends is also increasing, so that many male friends suffer from various male genital diseases.

It is well known that the natural characteristics of the male genitals make them inevitably harbor a lot of dirt. The male perineum includes penis, external orifice of urethra, foreskin, scrotum, perianal area and groin, and this area is affected by stool and urine and is prone to contamination and pathogen infection.

Firstly, phimosis and foreskin growers often cause foreskin balanitis due to local dirty and dirty containing, mold (such as candida albicans), bacteria and virus (such as human papilloma virus and genital herpes virus) infection; meanwhile, bacterial infection, fungal infection and the like can also cause scrotum dampness, scrotum eczema and perianal eczema, and the skin of the scrotum and the perianal skin is dry, thick and persistent for a long time. Secondly, infection and inflammation of penis and foreskin of man repeatedly cause scar formation of foreskin, and urethral external orifice stenosis, urinary retention and penis cancer occur.

Common genital diseases of males include male sexual dysfunction (including impotence and premature ejaculation), scrotal dampness, eczema of scrotum, etc. The number of the ill people is large, and the market is huge.

The current therapeutic status of the above diseases:

no effective treatment medicine exists for the scrotum with damp.

Eczema of scrotum: generally, hormone medicines are used for external treatment, and long-term use of the hormone medicines causes telangiectasia and pigmentation.

Erectile dysfunction: the traditional Chinese medicine is a PDE5 inhibitor oral medicine generally, has side effects of cardiovascular and visual disorders and the like, is generally used temporarily, treats the symptoms and the root causes, and does not have an external preparation with definite curative effect at present.

Premature ejaculation: generally, psychological or behavioral therapy is adopted, the curative effect is not exact, and no external preparation with exact curative effect exists at present.

In summary, the common diseases of male genitals lack external products with definite curative effects, the market demand is very large, various female care solutions are filled in the market at present, but the external male care preparations are few, which is related to the daily concept of people, the female genitals are considered to be fragile and easy to breed various germs, and the private male genitals do not need special care due to special physiological structures, and the view is very wrong from the clinical point of view. If a male is not fine-fitting with daily personal hygiene or has dirty behavior, the chance of the individual contracting a disease is greatly increased. Once infected, the life and work of the partner and family are seriously affected. Therefore, the development of safe and effective external products for male care has good market prospect.

Disclosure of Invention

The invention aims to provide a composition with dual functions of nursing and bacteriostasis aiming at male privates and a preparation method thereof. It is characterized in that: has antibacterial, antipruritic, aromatic, refreshing, and odor removing effects, and also has antibacterial and nursing effects, and can improve male premature ejaculation state, enhance male sexual function, care male privacy, and safety without adverse side effect.

The invention provides a composition with dual functions of nursing and bacteriostasis aiming at male private parts, which is characterized by being prepared from the following raw material medicines in parts by weight: 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

The medicine composition of the invention can also contain chlorhexidine acetate, benzalkonium bromide, nano silver and other antibacterial agents.

The medicine composition of the invention can also contain one or more than one of the traditional Chinese medicines of asarum, sophora flavescens, phellodendron, fructus kochiae and the like.

The preparation of the invention can be prepared by various conventional methods in pharmaceutics, such as:

the preparation method of the male private part nursing/bacteriostatic composition comprises the following steps: extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, herba asari, radix Sophorae Flavescentis, cortex Phellodendri, and Kochiae fructus with water by conventional method, concentrating, or precipitating with ethanol, recovering ethanol, and adding Borneolum Syntheticum and Mentholum.

In the above preparation process, if necessary, chlorhexidine acetate, benzalkonium bromide, and nanometer silver antibacterial agent can be added; adding appropriate amount of pharmaceutically-acceptable adjuvants such as cocamidopropyl betaine, glycerol, carbomer, allantoin, triethanolamine, alkaline water, stearic acid, and ethylparaben, and making into desired dosage forms such as lotion, gel, cream, etc.

And (3) bacteriostatic test of the product: the product has strong inhibiting effect on Candida albicans, Escherichia coli and Staphylococcus aureus.

Product irritation test: the test result of the complete skin irritation test for rabbits for many times shows that the skin irritation test for rabbits is nonirritating.

The application range is as follows: the product can be used for cleaning male private parts, daily care and care before and after sexual life. Can be used for treating scrotum dampness; eczema of scrotum; itch of the skin; neurodermatitis; improving premature ejaculation state and improving male sexual function.

Therapeutic effect summary

Disease species	Number of examples	Show effect	Is effective	Invalidation	Total effective rate
						Eczema of scrotum	35	10	18	7	80%
Moist scrotum	40	15	20	5	87.5%
						Premature ejaculation	36	10	18	8	77.78%
Impotence	40	10	20	10	75%
						Neurodermatitis	25	5	12	8	68%

Detailed Description

The present invention will be further described with reference to the following examples.

The invention comprises the following components in parts by weight:

(1) 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

The medicine composition of the invention can also contain one or more than one of traditional Chinese medicines such as lightyellow sophora root, amur corktree bark, belvedere fruit, manchurian wildginger and the like, and the mixture ratio is as follows:

(2) 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of asarum, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

(3) 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of radix sophorae flavescentis, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

(4) 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of phellodendron, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

(5) 1-40 parts of fructus cnidii, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of belvedere fruit, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

(6) 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of asarum, 0.5-30 parts of radix sophorae flavescentis, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

1. The preparation method of the medicine takes 1 to 40 parts of common cnidium fruit, 0.5 to 40 parts of clove, 0.5 to 30 parts of pepper, 0.5 to 30 parts of cinnamon, 0.5 to 30 parts of honeycomb, 0.1 to 30 parts of cynomorium songaricum, 0.01 to 0.5 part of borneol and 0.01 to 0.5 part of menthol as examples, and the following methods can be referred:

(1) extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, and nidus Vespae with water by conventional method, concentrating to obtain extract, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding cocamidopropyl betaine, glycerol, etc., and making into lotion.

(2) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, and nidus Vespae with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol and carbomer, and making into gel.

(3) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, and nidus Vespae with water, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol, stearic acid, and ethylparaben, and making into cream.

2. The preparation method of the medicine takes 1 to 40 parts of common cnidium fruit, 0.5 to 40 parts of clove, 0.5 to 30 parts of pepper, 0.5 to 30 parts of cinnamon, 0.5 to 30 parts of honeycomb, 0.1 to 30 parts of cynomorium songaricum, 0.5 to 30 parts of asarum, 0.01 to 0.5 part of borneol and 0.01 to 0.5 part of menthol as examples, and can refer to the following methods:

(1) extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and herba asari with water by conventional method, concentrating to obtain extract, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding cocamidopropyl betaine, glycerol, etc., and making into lotion.

(2) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and herba asari with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol and carbomer, and making into gel.

(3) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and herba asari with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol, stearic acid, and ethylparaben, and making into cream.

3. The preparation method of the medicine takes 1 to 40 parts of common cnidium fruit, 0.5 to 40 parts of clove, 0.5 to 30 parts of pepper, 0.5 to 30 parts of cinnamon, 0.5 to 30 parts of honeycomb, 0.1 to 30 parts of cynomorium songaricum, 0.5 to 30 parts of lightyellow sophora root, 0.01 to 0.5 part of borneol and 0.01 to 0.5 part of menthol as examples, and can refer to the following methods:

(1) extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and radix Sophorae Flavescentis with water by conventional method, concentrating to obtain extract, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding cocamidopropyl betaine, glycerol, etc., and making into lotion.

(2) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and radix Sophorae Flavescentis with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol and carbomer, and making into gel.

(3) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and radix Sophorae Flavescentis with water, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol, stearic acid, and ethylparaben, and making into cream.

4. The preparation method of the medicine takes 1 to 40 parts of common cnidium fruit, 0.5 to 40 parts of clove, 0.5 to 30 parts of pepper, 0.5 to 30 parts of cinnamon, 0.5 to 30 parts of honeycomb, 0.1 to 30 parts of cynomorium songaricum, 0.5 to 30 parts of amur corktree bark, 0.01 to 0.5 part of borneol and 0.01 to 0.5 part of menthol as examples, and can refer to the following methods:

(1) extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and cortex Phellodendri with water by conventional method, concentrating to obtain extract, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding cocamidopropyl betaine, glycerol, etc., and making into lotion.

(2) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and cortex Phellodendri with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol and carbomer, and making into gel.

(3) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and cortex Phellodendri with water, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol, stearic acid, and ethylparaben, and making into cream.

5. The preparation method of the medicine takes 1 to 40 parts of common cnidium fruit, 0.5 to 40 parts of clove, 0.5 to 30 parts of pepper, 0.5 to 30 parts of cinnamon, 0.5 to 30 parts of honeycomb, 0.1 to 30 parts of cynomorium songaricum, 0.5 to 30 parts of belvedere fruit, 0.01 to 0.5 part of borneol and 0.01 to 0.5 part of menthol as examples, and can refer to the following methods:

(1) extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and Kochiae fructus with water by conventional method, concentrating to obtain extract, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding cocamidopropyl betaine, glycerol, etc., and making into lotion.

(2) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and Kochiae fructus with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol and carbomer, and making into gel.

(3) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, and Kochiae fructus with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol, stearic acid, and ethylparaben, and making into cream.

6. The preparation method of the medicine takes 1 to 40 parts of common cnidium fruit, 0.5 to 40 parts of clove, 0.5 to 30 parts of pepper, 0.5 to 30 parts of cinnamon, 0.5 to 30 parts of honeycomb, 0.1 to 30 parts of cynomorium songaricum, 0.5 to 30 parts of asarum, 0.5 to 30 parts of radix sophorae flavescentis, 0.01 to 0.5 part of borneol and 0.01 to 0.5 part of menthol as examples, and the following methods can be referred to:

(1) extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, herba asari, and radix Sophorae Flavescentis with water by conventional method, concentrating to obtain extract, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding cocamidopropyl betaine, glycerol, etc., and making into lotion.

(2) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, herba asari, and radix Sophorae Flavescentis with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol and carbomer, and making into gel.

(3) Extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, cortex Cinnamomi, herba Cynomorii, nidus Vespae, herba asari, and radix Sophorae Flavescentis with water by conventional method, concentrating to obtain extract, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding chlorhexidine acetate or benzalkonium bromide or nanometer silver antibacterial agent, adding glycerol, stearic acid, and ethylparaben, and making into cream.

Claims

1. A composition with dual functions of bacteriostasis and nursing for male private parts is characterized by being prepared from the following raw material medicines in parts by weight: 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

2. A composition with dual functions of bacteriostasis and nursing for male private parts is characterized by being prepared from the following raw material medicines in parts by weight: 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of asarum, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

3. A composition with dual functions of bacteriostasis and nursing for male private parts is characterized by being prepared from the following raw material medicines in parts by weight: 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of radix sophorae flavescentis, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

4. A composition with dual functions of bacteriostasis and nursing for male private parts is characterized by being prepared from the following raw material medicines in parts by weight: 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of phellodendron, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

5. A composition with dual functions of bacteriostasis and nursing for male private parts is characterized by being prepared from the following raw material medicines in parts by weight: 1-40 parts of common cnidium fruit, 0.5-40 parts of clove, 0.5-30 parts of pepper, 0.5-30 parts of cinnamon, 0.5-30 parts of honeycomb, 0.1-30 parts of cynomorium songaricum, 0.5-30 parts of asarum, 0.5-30 parts of radix sophorae flavescentis, 0.01-0.5 part of borneol and 0.01-0.5 part of menthol.

6. Composition for combating and caring for male sexual intercourse according to claims 1 to 5, characterized in that said composition is in the form of a lotion or gel or cream.

7. A method for preparing the composition with the dual functions of bacteriostasis and nursing for male private parts as claimed in claim 1, which is characterized in that: extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, nidus Vespae, cortex Cinnamomi, and herba Cynomorii with water by conventional method, concentrating, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding antibacterial agent and medicinal adjuvants, and making into lotion, gel or cream.

8. A method for preparing the composition with the dual functions of bacteriostasis and nursing for the male private parts as claimed in claim 2, which is characterized in that: extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, nidus Vespae, cortex Cinnamomi, herba Cynomorii, and herba asari with water by conventional method, concentrating, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding antibacterial agent and medicinal adjuvants, and making into lotion, gel or cream.

9. A method for preparing the composition with the dual functions of bacteriostasis and nursing care for male private parts as claimed in claim 3, which is characterized in that: extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, nidus Vespae, cortex Cinnamomi, herba Cynomorii, and radix Sophorae Flavescentis with water by conventional method, concentrating, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding antibacterial agent and medicinal adjuvants, and making into lotion, gel or cream.

10. A method for preparing the composition with the dual functions of bacteriostasis and nursing care for male private parts as claimed in claim 4, which is characterized in that: extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, nidus Vespae, cortex Cinnamomi, herba Cynomorii, and cortex Phellodendri with water by conventional method, concentrating, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding antibacterial agent and medicinal adjuvants, and making into lotion, gel or cream.

11. A method for preparing the composition with the dual functions of bacteriostasis and nursing care for male private parts as claimed in claim 5, which is characterized in that: extracting fructus Cnidii, flos Caryophylli, fructus Zanthoxyli, nidus Vespae, cortex Cinnamomi, herba Cynomorii, radix Sophorae Flavescentis, and herba asari with water by conventional method, concentrating, precipitating with ethanol, recovering ethanol, adding Borneolum Syntheticum and Mentholum, adding antibacterial agent and medicinal adjuvants, and making into lotion, gel or cream.