CN101380447A - Chitose foaming agent for treating gynecologic disease and preparation method thereof - Google Patents

Chitose foaming agent for treating gynecologic disease and preparation method thereof Download PDF

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Publication number
CN101380447A
CN101380447A CNA2008101991843A CN200810199184A CN101380447A CN 101380447 A CN101380447 A CN 101380447A CN A2008101991843 A CNA2008101991843 A CN A2008101991843A CN 200810199184 A CN200810199184 A CN 200810199184A CN 101380447 A CN101380447 A CN 101380447A
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chitosan
parts
emulsion
essence
chitose
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CNA2008101991843A
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Chinese (zh)
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周小萍
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Abstract

The invention relates to a chitosan bubble bath for curing gynecological diseases and a preparation method thereof. The bubble bath mainly comprises the following components: chitosan, manno-oligosaccharides, benzalkonium chloride, aloe, oil of zedoary turmeric, triclosan, NPE, coconut oil base CMEA, polyethyleneglycol 400, sodium dodecyl sulfate, ammonium lauryl sulfate, tween, trolamine, purified water, butane, etc. The chitosan bubble bath is a novel gynecological medicine which is non-toxic, safe and degraded. The invention has the advantages of pure antibiotic activity, wide antimicrobial spectrum and prominent bacteriostasis effect on gram-positive bacteria, Gram-negative bacteria and Candida albicans. The chitosan bubble bath has the characteristics of innocuity, biodegradability (can be degraded by multiple enzyme biology such as muramidase, pepsin, and the like, in a body; the degradation products are nontoxic and can be fully absorbed by organism), good biocompatibility, film formation, etc. The chitosan bubble bath has the special functions of strengthening immunity, moistening and promoting the growth of epidermis, accelerating tissue repair, etc.

Description

A kind of chitose foaming agent that is used for the treatment of gynaecopathia and preparation method thereof
Technical field
The present invention relates to a kind of chitose foaming agent that is used for the treatment of gynaecopathia and preparation method thereof, relate to a kind of Nantural non-toxic, safety, efficient biodegradable novel chitosan foam that is used for the treatment of gynaecopathia and preparation method thereof specifically
Background technology
At present, gynecological's reproductive tract infection diseases such as female vagina cervicitis and cervical erosion have become the principal disease of harm modern female health.Face the problems that the healthy reproduction field need solve, people are with the control of the reproductive tract infection important component part as healthy reproduction, reproductive tract infection is not only to self causing the injury of body and mind two aspects, also can jeopardize other people, bring disaster to the offspring, causing serious society and financial burden, is that one of human health is threatened greatly.Spread unchecked immoderate use along with antibiotic, some originally to the extremely strong antibiotic of antibacterial lethality because the generation of bacterial drug resistance, cause their therapeutic dose constantly to increase, therefore treatment cycle constantly prolongs, seek a kind of non-antibiotic class, having the natural bactericidal agent product that broad-spectrum antiseptic has no drug resistance is the task of top priority.
Studies show that both at home and abroad chitosan is the biodegradable chemical compound of a kind of Nantural non-toxic, and excellent biological compatibility is arranged between the body.Has the hypoglycemic function of tangible reducing blood pressure and blood fat; Have the wound infection of preventing, promote the function of granulation growth and skin regeneration; Has the microcirculatory function of the gastrointestinal tract of adjusting.Because above-mentioned multiple biological activity is described as human the 6th vital principle.At present, chitosan has become the focus of research in the application of field of medicaments.The application chitosan is reported with anti-biotic material is existing as the women of main component: Chinese invention patent (application number is 200510022292) discloses a kind of vagina nursing for treating compositions, include chitosan or its cationic derivant that weight percent content is 0.1%-99%, can be used for treating gynecological inflammation; Chinese invention patent (application number is 200510035046) discloses a kind of Chitosangynaecologicsuppository suppository, comprises major ingredient chitosan and adjuvant polyoxyethylene monostearate, and gynaecopathias such as vaginitis, cervical erosion are had better curative effect; Chinese invention patent (application number is 03112762) discloses a kind of bio-sponge body that is used for the treatment of gynaecopathia, is raw material with the former chitin hydrophilic of chitosan gum polysaccharide, and this product is suitable for gynaecopathias such as treatment cervicitis, vaginitis.
Summary of the invention
The object of the present invention is to provide a kind of Nantural non-toxic, safe, efficient, biodegradable novel chitosan foam that is used for the treatment of gynaecopathia and preparation method thereof.
Technical scheme of the present invention is:
The safe and efficient biodegradable novel chitosan foam of Nantural non-toxic of the present invention is made by weight proportion by following raw material:
Chitosan 1-10 part, manna oligosaccharide 1-10 part, benzalkonium chloride 0.1-1 part, aloe 1-10 part, Oleum Curcumae 1-10 part, triclosan 0.1-2 part, NPE 1-10 part, Cortex cocois radicis oil base alkanolamide 1-10 part, PEG400 5-10 part, sodium lauryl sulphate 1-10 part, dodecyl alcohol ether ammonium sulfate 1-10 part, tween 1-10 part, triethanolamine 0.5-10 part, purified water 50-90 part, third butane 5-20 part
Chitose foaming agent of the present invention is prepared by following method:
With chitosan 1-10 part, manna oligosaccharide 1-10 part, benzalkonium chloride 0.1-1 part, aloe 1-10 part, Oleum Curcumae 1-10 part, triclosan 0.1-2 part, NPE 1-10 part, Cortex cocois radicis oil base alkanolamide 1-10 part places the container that fills suitable quantity of water, constantly grinds, stirs, and gets the A emulsion; With PEG400 5-10 part, sodium lauryl sulphate 1-10 part, dodecyl alcohol ether ammonium sulfate 1-10 part, tween 1-10 part, triethanolamine 0.5-10 part places the container that fills suitable quantity of water, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, with the filtrate quantitative filling, seal, recharge adding third butane 5-20 part, check weight, detect and leak, add a cover, packing promptly
Above-mentioned essence is Oleum Camelliae essence or Fructus Citri Limoniae essence or rose essence or Herba Menthae essence; Above-mentioned foam is external spraying agent or aerosol
The novel chitosan foam spraying agent of treatment gynaecopathia of the present invention or the preparation method of aerosol are known in those skilled in the art, can carry out according to the preparation method of common spray or aerosol
The present invention has the following advantages:
1. this anti-bacteria foaming agent has the natural antibacterial activity, and has a broad antifungal spectrum all has tangible fungistatic effect to gram positive bacteria gram negative bacteria and Candida albicans.
2. this anti-bacteria foaming agent has poisonless biological degradable (can by plurality of enzymes biodegradations such as lysozyme pepsin in the body, catabolite is nontoxic can be absorbed fully by organism) and has characteristics such as good biocompatibility and film property
3. this anti-bacteria foaming agent also has enhancing immunity, preserves moisture, promotes specific functions such as epithelial growth acceleration of tissue repair
The specific embodiment
Below set forth the present invention by instantiation, it should be understood that these embodiment only be used for the explanation, do not limit the scope of the invention
Embodiment 1
With 2 parts of chitosans, 2 parts of manna oligosaccharide, 0.2 part of benzalkonium chloride, 2 parts of aloes, 2 parts of Oleum Curcumae, 0.5 part of triclosan, 2 parts of NPEs, Cortex cocois radicis oil base alkanolamide places the container that fills suitable quantity of water for 2 parts, constantly grinds to stir, and gets the A emulsion; With 5 parts of PEG400s, 2 parts of sodium lauryl sulphates, 2 parts of dodecyl alcohol ether ammonium sulfates, 2 parts of tweens, triethanolamine places the container that fills suitable quantity of water for 0.5 part, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, with the filtrate quantitative filling, seal, recharge 5 parts of adding third butane, check weight, detect and leak, add a cover, packing promptly
Embodiment 2
With 4 parts of chitosans, 4 parts of manna oligosaccharide, 0.5 part of benzalkonium chloride, 4 parts of aloes, 4 parts of Oleum Curcumae, 0.5 part of triclosan, 4 parts of NPEs, Cortex cocois radicis oil base alkanolamide places the container that fills suitable quantity of water for 4 parts, constantly grinds to stir, and gets the A emulsion; With 7 parts of PEG400s, 4 parts of sodium lauryl sulphates, 4 parts of dodecyl alcohol ether ammonium sulfates, 4 parts of tweens, triethanolamine places the container that fills suitable quantity of water for 2 parts, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, with the filtrate quantitative filling, seal, recharge 10 parts of adding third butane, check weight, detect and leak, add a cover, packing promptly
Embodiment 3
With 6 parts of chitosans, 6 parts of manna oligosaccharide, 0.6 part of benzalkonium chloride, 6 parts of aloes, 6 parts of Oleum Curcumae, 1 part of triclosan, 6 parts of NPEs, Cortex cocois radicis oil base alkanolamide places the container that fills suitable quantity of water for 6 parts, constantly grinds to stir, and gets the A emulsion; With 6 parts of PEG400s, 6 parts of sodium lauryl sulphates, 6 parts of dodecyl alcohol ether ammonium sulfates, 6 parts of tweens, triethanolamine places the container that fills suitable quantity of water for 6 parts, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, with the filtrate quantitative filling, seal, recharge 10 parts of adding third butane, check weight, detect and leak, add a cover, packing promptly
Embodiment 4
With 8 parts of chitosans, 8 parts of manna oligosaccharide, 1 part of benzalkonium chloride, 8 parts of aloes, 8 parts of Oleum Curcumae, 1.2 parts of triclosan, 8 parts of NPEs, Cortex cocois radicis oil base alkanolamide places the container that fills suitable quantity of water for 8 parts, constantly grinds to stir, and gets the A emulsion; With 8 parts of PEG400s, 8 parts of sodium lauryl sulphates, 8 parts of dodecyl alcohol ether ammonium sulfates, 8 parts of tweens, triethanolamine places the container that fills suitable quantity of water for 8 parts, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, with the filtrate quantitative filling, seal, recharge 15 parts of adding third butane, check weight, detect and leak, add a cover, packing promptly
Embodiment 5
With 10 parts of chitosans, 10 parts of manna oligosaccharide, 1 part of benzalkonium chloride, 10 parts of aloes, 10 parts of Oleum Curcumae, 2 parts of triclosan, 10 parts of NPEs, Cortex cocois radicis oil base alkanolamide places the container that fills suitable quantity of water for 10 parts, constantly grinds, stirs, and gets the A emulsion; With 10 parts of PEG400s, 10 parts of sodium lauryl sulphates, 10 parts of dodecyl alcohol ether ammonium sulfates, 10 parts of tweens, triethanolamine places the container that fills suitable quantity of water for 10 parts, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, the filtrate quantitative filling is sealed, add 20 parts of third butane again, check weight, detect and leak, add a cover, packing promptly

Claims (4)

1. chitose foaming agent that is used for the treatment of gynaecopathia is characterized in that the ratio of each component is:
Chitosan 1-10 part, manna oligosaccharide 1-10 part, benzalkonium chloride 0.1-1 part, aloe 1-10 part, Oleum Curcumae 1-10 part, triclosan 0.1-2 part, NPE 1-10 part, Cortex cocois radicis oil base alkanolamide 1-10 part, PEG400 5-10 part, sodium lauryl sulphate 1-10 part, dodecyl alcohol ether ammonium sulfate 1-10 part, tween 1-10 part, triethanolamine 0.5-10 part, purified water 50-90 part, third butane 5-20 part
2. a kind of chitose foaming agent that is used for the treatment of gynaecopathia as claimed in claim 1 is characterized in that this foam is external spraying agent or aerosol
3. a kind of chitose foaming agent that is used for the treatment of gynaecopathia as claimed in claim 1 is characterized in that it is prepared by following method:
With chitosan 1-10 part, manna oligosaccharide 1-10 part, benzalkonium chloride 0.1-1 part, aloe 1-10 part, Oleum Curcumae 1-10 part, triclosan 0.1-2 part, NPE 1-10 part, Cortex cocois radicis oil base alkanolamide 1-10 part places the container that fills suitable quantity of water, and it is even constantly to grind stirring x, gets the A emulsion; With PEG400 5-10 part, sodium lauryl sulphate 1-10 part, dodecyl alcohol ether ammonium sulfate 1-10 part, tween 1-10 part, triethanolamine 0.5-10 part places the container that fills suitable quantity of water, stir the B emulsion; A emulsion and B emulsion are mixed, add remaining purified water again, stir, add the essence of recipe quantity, filter, with the filtrate quantitative filling, seal, recharge adding third butane 5-20 part, check weight, detect and leak, add a cover, packing promptly
4. a kind of chitose foaming agent that is used for the treatment of gynaecopathia as claimed in claim 3 is characterized in that described essence is Oleum Camelliae essence or Fructus Citri Limoniae essence or rose essence or Herba Menthae essence
CNA2008101991843A 2008-10-16 2008-10-16 Chitose foaming agent for treating gynecologic disease and preparation method thereof Pending CN101380447A (en)

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Application Number Priority Date Filing Date Title
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012107390A1 (en) 2011-02-10 2012-08-16 Unilever Nv Antimicrobial composition
CN102872159A (en) * 2012-09-29 2013-01-16 广东同德药业有限公司 Nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation, and preparation method thereof
CN104042791A (en) * 2014-07-07 2014-09-17 江苏瑞京科技发展有限公司 Antibacterial modified chitosan foaming agent and preparation method thereof
CN104474547A (en) * 2015-01-07 2015-04-01 蓝佳堂生物医药(福建)有限公司 Vaginal infection prevention immune globulin compound preservative
CN104740141A (en) * 2015-04-16 2015-07-01 广东泰宝医疗科技股份有限公司 Antibacterialp spray and preparation method thereof
CN105168676A (en) * 2015-09-25 2015-12-23 湖北穆兰同大科技有限公司 Female safety antimicrobial gel and preparation method thereof
CN106727319A (en) * 2017-01-09 2017-05-31 广州润虹医药科技有限公司 A kind of gynaecology's foaming agent and preparation method thereof
CN107224816A (en) * 2017-06-21 2017-10-03 河池市森机械有限责任公司 Dedusting foam concentrate
CN109316444A (en) * 2018-11-09 2019-02-12 南京道大药业有限公司 A kind of antibacterial chitose foaming agent and preparation method thereof

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103347386A (en) * 2011-02-10 2013-10-09 荷兰联合利华有限公司 Antimicrobial composition
WO2012107390A1 (en) 2011-02-10 2012-08-16 Unilever Nv Antimicrobial composition
CN103347386B (en) * 2011-02-10 2016-08-10 荷兰联合利华有限公司 Antimicrobial compositions
EA025996B1 (en) * 2011-02-10 2017-02-28 Юнилевер Нв Antimicrobial composition
CN102872159A (en) * 2012-09-29 2013-01-16 广东同德药业有限公司 Nano-silver chitosan gel foam preparation for treating vaginal bacterial inflammation, and preparation method thereof
CN104042791B (en) * 2014-07-07 2017-06-27 江苏瑞京科技发展有限公司 A kind of antibacterial modified chitose foaming agent and preparation method thereof
CN104042791A (en) * 2014-07-07 2014-09-17 江苏瑞京科技发展有限公司 Antibacterial modified chitosan foaming agent and preparation method thereof
CN104474547A (en) * 2015-01-07 2015-04-01 蓝佳堂生物医药(福建)有限公司 Vaginal infection prevention immune globulin compound preservative
CN104740141A (en) * 2015-04-16 2015-07-01 广东泰宝医疗科技股份有限公司 Antibacterialp spray and preparation method thereof
CN105168676A (en) * 2015-09-25 2015-12-23 湖北穆兰同大科技有限公司 Female safety antimicrobial gel and preparation method thereof
CN105168676B (en) * 2015-09-25 2019-12-03 湖北穆兰同大科技有限公司 Safe bacteriostatic gel of Ms and preparation method thereof
CN106727319A (en) * 2017-01-09 2017-05-31 广州润虹医药科技有限公司 A kind of gynaecology's foaming agent and preparation method thereof
CN107224816A (en) * 2017-06-21 2017-10-03 河池市森机械有限责任公司 Dedusting foam concentrate
CN109316444A (en) * 2018-11-09 2019-02-12 南京道大药业有限公司 A kind of antibacterial chitose foaming agent and preparation method thereof

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Open date: 20090311