CN109316444A - A kind of antibacterial chitose foaming agent and preparation method thereof - Google Patents
A kind of antibacterial chitose foaming agent and preparation method thereof Download PDFInfo
- Publication number
- CN109316444A CN109316444A CN201811330626.3A CN201811330626A CN109316444A CN 109316444 A CN109316444 A CN 109316444A CN 201811330626 A CN201811330626 A CN 201811330626A CN 109316444 A CN109316444 A CN 109316444A
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- China
- Prior art keywords
- antibacterial
- chitose
- foaming agent
- preparation
- chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a kind of antibacterial modified chitose foaming agents and preparation method thereof, belong to medical supplies technical field, for solve at present lack the environmental protection of pure chitosan class, efficient foam agent, production method is complicated the problems such as, provide a kind of antibacterial modified chitose foaming agent and preparation method thereof, including by chitosan stirring and dissolving in glacial acetic acid, it is subsequently added into polysorbate60 stirring and dissolving, obtain a kind of composite solution of chitosan-containing, it is eventually adding purified water, stirring and dissolving is uniform, obtains the antibacterial chitose foaming agent.Antibacterial chitose foaming agent of the invention reaches 99% or more to the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Candida albicans or Pseudomonas aeruginosa etc., show good bacteriostasis, it can be applied to treatment bacterial vaginitis, colpomycosis and mixed vaginitis etc., application is very extensive.
Description
Technical field
The invention belongs to medical drugs technical fields, and in particular to a kind of antibacterial chitose foaming agent further relates to described anti-
The preparation method of bacterium chitose foaming agent.
Background technique
Vaginitis is a kind of reproductive organs inflammation that women is common, and in married woman, more than half crowd suffers from different journeys
Vaginitis is clinically probably divided into more than ten kinds by the vaginitis of degree, specifically includes bacterial vaginitis, trichomonas vaginitis, thought
Pearl bacterium property vaginitis, senile vahinitis, infantile vaginitis, candidiasis vaginitis, viral HSV, HPv vagina
Inflammation, gonococcal vaginitis, desquamative inflammatory vaginitis, nonspecific vaginitis, Tuberculous vaginitis, Drug vaginitis, radioactivity
Vaginitis, ulcer of vagina are acute, anaphylaxis vaginitis, chronic vaginitis, burn worm property vaginitis and mixed vaginitis etc., than
Vaginitis more typical and more serious to women's health hazard ratio is mainly bacterial vaginitis, trichomonas vaginitis and thought
Pearl bacterium property vaginitis, be embodied in vulva convulsion itch, generate heat, is scorching hot, the symptoms such as leucorrhea increasing peculiar smell, discomfort, be that gynaecology is common
Disease, frequently-occurring disease seriously endanger WomanHealth, bring inconvenience to the work and life of patient.
Vaginitis external manifestation is mainly local disease, so inside subduing medicine based on controlling other than basic on its remedy measures
Supplemented by.In external therapy, many new methods have been developed in recent years and have developed many therapeutant dosage forms, such as washing lotion, vagina
Bolt, vaginal tablets, powder, paste, paste and capsule, film etc..Washing lotion is mainly external application, cannot for a long time and focal contact,
Therefore drug effect cannot be effectively played, daily health caring medication can only be used as；Paste, vaginal tablets and vaginal plug work in intravaginal
Slowly, it can not be come into full contact with lesion, drug dispersion is uneven, and when use will directly be operated with hand, and drug easy to pollute causes to intersect
Infection, in addition, returning patient brings foreign body sensation.
There is inconvenience in use in view of the above healing potion, that there are contacts area is small, assimilation effect is bad, easy
The shortcomings that the deficiencies of causing cross-infection is developed new dosage form-foaming agent, and foaming agent overcomes above-mentioned dosage form, can make
Drug is uniformly distributed in intravaginal, is come into full contact with, is absorbed rapidly, good effect with vagina mucosa wrinkle skirt.
Currently, people have carried out extensive research to foaming agent, such as CN101380447A discloses one kind for treating
Chitose foaming agent of gynecological disease and preparation method thereof, the chitose foaming agent are to prick chlorine by chitosan, mannan-oligosaccharides, benzene
Ammonium, aloe, oil of zedoary turmeric, triclosan, nonylphenol polyoxyethylene ether, coconut oil base alkanolamide, polyethylene glycol 400, dodecane
Base sodium sulphate, dodecyl ether sulfate ammonium, tween, triethanolamine, purified water and the third butane etc. be compound to be formulated；
CN102872160A discloses a kind of nano silver foam agent sterilized for hot burn, ulcer wound, the nano silver foam agent
Be by nano-silver colloid solution, chitosan, solubilizer, wetting agent, thickener, preservative, foaming agent, Fungicidal substance, refrigerant substance,
PH, which withers, to be saved made of agent and propellant；CN 102895256A discloses a kind of suitable for the dual contraceptive efficacy of women barrier spermicidal
Chitosan plural gel foaming agent and preparation method thereof, it be by chitosan gel rubber matrix and surfactant, ancillary drug,
Made of cosolvent, Acidifier, foaming agent, foam stabiliser, solvent and propellant.
There are following technological deficiencies for these technologies: one, they are all using including propane, butane or iso-butane, halogenated hydrocarbons etc.
Treib gasaerosole, two, addition drug dressing it is wide in variety, complex manufacturing process；Though the three, matrix based on chitosan, all
Other antimicrobial components, such as triclosan, nano silver, borneol, menthol ingredient are added.State Food and Drug Administration's mesh
It is preceding to have expressly provided, chlorofluorocarbon substance should be gradually eliminated as pharmaceutic adjuvant aerosol for external use, in addition, propellant can be to yin
There is certain irritation in road, therefore, researches and develops that a kind of to make simple, safe and environment-friendly vaginal foaming agent extremely urgent.
It is an object of the invention to overcome disadvantage existing in the prior art, solve to lack at present the environmental protection of pure chitosan class,
Efficient foam agent, the problems such as production method is complicated propose the preparation method of an antibacterial chitosan anti-bacteria foaming agent, the foam of acquisition
Agent has subtle foaming structure, and antibacterial wide spectrum effect is good, and lesion cell can be promoted to restore, and preparation and application method letter
It is single, treatment, nursing of various vaginitis of clinical gynaecology etc. can be advantageously used in.
Summary of the invention
The present invention is the problems such as solution lacks the environmental protection of pure chitosan class, efficient foam agent at present, production method is complicated, is provided
A kind of antibacterial chitose foaming agent and preparation method thereof.
The technical solution adopted by the invention is as follows:
A kind of antibacterial chitose foaming agent and preparation method thereof, includes the following steps:
A: by 0.8-1.0 parts by weight chitosan stirring and dissolving in glacial acetic acid；
B: it is subsequently added into 0.08-0.12 parts by weight polysorbate60 stirring and dissolving, obtains a kind of composite solution of chitosan-containing；
C: being added 40-100 parts by weight purified water, and stirring and dissolving is uniform, obtains the antibacterial chitose foaming agent.
Mixing speed described in step A is 250-300rpm, and the dissolution time is 5-10min.
The weight ratio of chitosan described in step A and glacial acetic acid is 6-7:1.
Mixing speed described in step B is 250-300rpm, and the dissolution time is 10-15min.
Mixing speed described in step C is 250-300rpm, and the dissolution time is 10-15min.
Antibacterial chitose foaming agent is to staphylococcus aureus, Escherichia coli, streptococcus, Candida albicans or Pseudomonas aeruginosa
Antibacterial ability reach 99% or more.
Beneficial effects of the present invention:
1, antibacterial chitose foaming agent main body of the invention uses natural products chitosan, improves the biology peace of foaming agent
Quan Xing, meanwhile, it avoids improving safety in utilization and environmental protection using stock solution.
2, antibacterial chitose foaming agent prepared by the present invention is by the anti-harmful microorganism effect of amino-containing chitosan, to thin
Bacterium, fungi all have obvious killing effect, to staphylococcus aureus, hemolytic chain bacterium, Pseudomonas aeruginosa, Candida albicans with
And the clinical bacterias such as Escherichia coli have 99% or more killing efficiency, and anti-microbial property is greatly improved.
Specific embodiment
Technical solution of the present invention is clearly and completely described by following embodiments, it is clear that described implementation
Example is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff every other embodiment obtained without making creative work, belongs to model of the invention
It encloses.
Embodiment 1:
The implementation steps of the embodiment are as follows:
0.8 parts by weight chitosan stirring and dissolving is in glacial acetic acid, mixing speed 280rpm, and dissolution time is 1 0min,
It is subsequently added into 0.1 parts by weight polysorbate60 stirring and dissolving, mixing speed 280rpm, dissolution time 10min are obtained after dissolution
70 parts by weight purified waters are added in a kind of composite solution of chitosan-containing, and stirring and dissolving is uniform, mixing speed 280rpm, dissolution
Time is 10min, obtains chitose foaming agent.
The antibacterial detection method of national standard described according to this specification, which tests and analyzes, to be determined, antibacterial shell manufactured in the present embodiment
Glycan foaming agent reaches 99.2% to the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Pseudomonas aeruginosa.
Embodiment 2:
The implementation steps of the embodiment are as follows:
By 0.9 parts by weight chitosan stirring and dissolving in glacial acetic acid, mixing speed 280rpm, dissolution time is
10min is subsequently added into 0.1 parts by weight polysorbate60 stirring and dissolving, mixing speed 280rpm, dissolution time 10min, after dissolution
A kind of composite solution of chitosan-containing is obtained, 70 parts by weight purified waters are added, stirring and dissolving is uniform, mixing speed 280rpm,
Dissolution time is 10min, obtains chitose foaming agent.
The antibacterial detection method of national standard described according to this specification, which tests and analyzes, to be determined, antibacterial manufactured in the present embodiment changes
Property chitose foaming agent reaches the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Pseudomonas aeruginosa
99.5%.
Embodiment 3:
The implementation steps of the embodiment are as follows:
By 1.0 parts by weight chitosan stirring and dissolvings in glacial acetic acid, mixing speed 280rpm, dissolution time is
10min is subsequently added into 0.1 parts by weight polysorbate60 stirring and dissolving, mixing speed 280rpm, dissolution time 10min, dissolution
A kind of composite solution of chitosan-containing is obtained afterwards, 70 parts by weight purified waters is added, stirring and dissolving is uniform, and mixing speed is
280rpm, dissolution time 10min, obtains chitose foaming agent.
The antibacterial detection method of national standard described according to this specification, which tests and analyzes, to be determined, antibacterial manufactured in the present embodiment changes
Property chitose foaming agent reaches the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Pseudomonas aeruginosa
99.3%.
Embodiment 4:
The implementation steps of the embodiment are as follows:
By 0.9 parts by weight chitosan stirring and dissolving in glacial acetic acid, mixing speed 280rpm, dissolution time is
10min is subsequently added into 0.1 parts by weight polysorbate60 stirring and dissolving, mixing speed 280rpm, dissolution time 10min, dissolution
A kind of composite solution of chitosan-containing is obtained afterwards, 70 parts by weight purified waters is added, stirring and dissolving is uniform, and mixing speed is
280rpm, dissolution time 10min, obtains chitose foaming agent.
The antibacterial detection method of national standard described according to this specification, which tests and analyzes, to be determined, antibacterial manufactured in the present embodiment changes
Property chitose foaming agent reaches the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Pseudomonas aeruginosa
99.1%.
Embodiment 5:
The implementation steps of the embodiment are as follows:
By 0.9 parts by weight chitosan stirring and dissolving in glacial acetic acid, mixing speed 280rpm, dissolution time is
10min is subsequently added into 0.1 parts by weight polysorbate60 stirring and dissolving, mixing speed 280rpm, dissolution time 10min, dissolution
A kind of composite solution of chitosan-containing is obtained afterwards, 70 parts by weight purified waters is added, stirring and dissolving is uniform, and mixing speed is
280rpm, dissolution time 10min, obtains chitose foaming agent.
The antibacterial detection method of national standard described according to this specification, which tests and analyzes, to be determined, antibacterial manufactured in the present embodiment changes
Property chitose foaming agent reaches the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Pseudomonas aeruginosa
99.2%.
While there has been shown and described that our bright embodiment for the ordinary skill in the art can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of antibacterial chitose foaming agent and preparation method thereof, characterized by the following steps:
A: by 0.8-1.0 parts by weight chitosan stirring and dissolving in glacial acetic acid；
B: it is subsequently added into 0.08-0.12 parts by weight polysorbate60 stirring and dissolving, obtains the composite solution of chitosan-containing；
C: 40-100 parts by weight purified water is added, stirring and dissolving is uniform, obtains antibacterial chitose foaming agent.
2. a kind of antibacterial chitose foaming agent according to claim 1 and preparation method thereof, it is characterised in that: in step A,
Mixing speed is 250-300rpm, dissolution time 5-10min.
3. a kind of antibacterial chitose foaming agent according to claim 1 and preparation method thereof, it is characterised in that: chitosan and
The weight ratio of glacial acetic acid is 6-7:1.
4. a kind of antibacterial chitose foaming agent according to claim 1 and preparation method thereof, it is characterised in that: in step B,
Mixing speed is 250-300rpm, dissolution time 10-15min.
5. a kind of antibacterial chitose foaming agent according to claim 1 and preparation method thereof, it is characterised in that: in step C,
Mixing speed is 250-300rpm, dissolution time 10-15min.
6. a kind of antibacterial chitose foaming agent according to claim 1 and preparation method thereof, it is characterised in that: antibacterial shell is poly-
Sugarwhips agent reaches the antibacterial ability of staphylococcus aureus, Escherichia coli, streptococcus, Candida albicans or Pseudomonas aeruginosa
99% or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811330626.3A CN109316444A (en) | 2018-11-09 | 2018-11-09 | A kind of antibacterial chitose foaming agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811330626.3A CN109316444A (en) | 2018-11-09 | 2018-11-09 | A kind of antibacterial chitose foaming agent and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN109316444A true CN109316444A (en) | 2019-02-12 |
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| CN201811330626.3A Pending CN109316444A (en) | 2018-11-09 | 2018-11-09 | A kind of antibacterial chitose foaming agent and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004041118A2 (en) * | 2002-10-31 | 2004-05-21 | Umd, Inc. | Therapeutic compositions for drug delivery to and through covering epithelia |
| CN101380447A (en) * | 2008-10-16 | 2009-03-11 | 周小萍 | Chitose foaming agent for treating gynecologic disease and preparation method thereof |
| CN102895256A (en) * | 2012-09-29 | 2013-01-30 | 广东同德药业有限公司 | Chitosan plural gel foaming agent suitable for female sperm shielding and killing dual-contraception effect and preparation method thereof |
| CN104042791A (en) * | 2014-07-07 | 2014-09-17 | 江苏瑞京科技发展有限公司 | Antibacterial modified chitosan foaming agent and preparation method thereof |
| CN106727319A (en) * | 2017-01-09 | 2017-05-31 | 广州润虹医药科技有限公司 | A kind of gynaecology's foaming agent and preparation method thereof |
| CN108158995A (en) * | 2017-12-29 | 2018-06-15 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof |
-
2018
- 2018-11-09 CN CN201811330626.3A patent/CN109316444A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004041118A2 (en) * | 2002-10-31 | 2004-05-21 | Umd, Inc. | Therapeutic compositions for drug delivery to and through covering epithelia |
| CN101380447A (en) * | 2008-10-16 | 2009-03-11 | 周小萍 | Chitose foaming agent for treating gynecologic disease and preparation method thereof |
| CN102895256A (en) * | 2012-09-29 | 2013-01-30 | 广东同德药业有限公司 | Chitosan plural gel foaming agent suitable for female sperm shielding and killing dual-contraception effect and preparation method thereof |
| CN104042791A (en) * | 2014-07-07 | 2014-09-17 | 江苏瑞京科技发展有限公司 | Antibacterial modified chitosan foaming agent and preparation method thereof |
| CN106727319A (en) * | 2017-01-09 | 2017-05-31 | 广州润虹医药科技有限公司 | A kind of gynaecology's foaming agent and preparation method thereof |
| CN108158995A (en) * | 2017-12-29 | 2018-06-15 | 广州润虹医药科技股份有限公司 | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 唐春红等: "《天然防腐剂与抗氧化剂》", 31 May 2010, 中国轻工业出版社 * |
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Application publication date: 20190212 |