CN102018780B - Skin bacteriostatic agent and preparation method thereof - Google Patents
Skin bacteriostatic agent and preparation method thereof Download PDFInfo
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- CN102018780B CN102018780B CN2010105872624A CN201010587262A CN102018780B CN 102018780 B CN102018780 B CN 102018780B CN 2010105872624 A CN2010105872624 A CN 2010105872624A CN 201010587262 A CN201010587262 A CN 201010587262A CN 102018780 B CN102018780 B CN 102018780B
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Abstract
The invention discloses a skin bacteriostatic agent, and simultaneously discloses a preparation method of the skin bacteriostatic agent. Per L of the skin bacteriostatic agent is prepared from the following raw materials: 15-20g of moxa leaves, 1-3g of cordyceps sinensis, 3-6g of red flower, 3-6g of radix clematidis, 3-6g of broom cypress fruit, 5-10g of common cnidium fruit, 2-6g of radix sophorae flavescentis, 3-8g of angelica sinensis, 100ml of propylene glycol, 6-10g of 1-n-Dodecylazacycloneptan-2-ketone, 60g of salicylic acid, 30-50g of dyclonine, 1-5g of phenol, and the balance of 75% ethanol water solution. The skin bacteriostatic agent provided by the invention has obvious curative effect, can be used for treating various skin diseases, and has the advantages of wide use range, short treatment course, instant effect, and no toxic and side effect; and the disease can not relapse after being treated.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, be specifically related to a kind of skin bacteria inhibitor and preparation method thereof.
Background technology
Dermatosis is a kind of common disease.Skin infection and dermatosis all can cause dermatosis, and wherein the dermatosis that causes of skin infection is more common.Skin infection is caused by antibacterial or fungus that mainly for example therefore staphylococcus aureus, escherichia coli and Candida albicans etc. generally adopt sterilization, bacteriostatic Therapeutic Method in the dermopathic clinical treatment that skin infection causes.The external sterilizing bactericide that is used to treat the skin infection dermatoses at present is more, but these medicines exist curative effect not remarkable in varying degrees, and treatment is sick plants single or shortcoming such as the course of treatment is long, even also there is toxic and side effects in some medicine.
Summary of the invention
The object of the present invention is to provide a kind of skin bacteria inhibitor evident in efficacy, easy to use.
Simultaneously, the present invention also aims to provide a kind of method for preparing of skin bacteria inhibitor.
In order to realize above purpose; The technical scheme that the present invention adopted is: a kind of skin bacteria inhibitor; Every liter of skin bacteria inhibitor is formed by following feedstock production: Folium Artemisiae Argyi 15-20 gram, Cordyceps 1-3 gram, Flos Carthami 3-6 gram, Radix Clematidis 3-6 gram, Fructus Kochiae 3-6 gram, Fructus Cnidii 5-10 gram, Radix Sophorae Flavescentis 2-6 gram, Radix Angelicae Sinensis 3-8 gram, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 6-10 gram, salicylic acid 60 grams, dyclonine 30-50 gram, phenol 1-5 gram, all the other concentration that are weight percentage are 75% ethanol water.
Further; Every liter of said skin bacteria inhibitor is formed by following feedstock production: Folium Artemisiae Argyi 18 grams, Cordyceps 2 grams, Flos Carthami 3 grams, Radix Clematidis 5 grams, the Fructus Kochiae 6 grams, Fructus Cnidii 7 grams, Radix Sophorae Flavescentis 5 grams, Radix Angelicae Sinensis 6 grams, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 10 grams, salicylic acid 60 grams, dyclonine 35 grams, phenol 2 grams, all the other concentration that are weight percentage are 75% ethanol water.
A kind of method for preparing of skin bacteria inhibitor may further comprise the steps:
(1) takes by weighing 15-20 gram Folium Artemisiae Argyi, 1-3 gram Cordyceps, 3-6 gram Flos Carthami, 3-6 gram Radix Clematidis, the 3-6 gram Fructus Kochiae, 5-10 gram Fructus Cnidii, 2-6 gram Radix Sophorae Flavescentis, 3-8 and restrain Radix Angelicae Sinensis; Put into water afterwards and be heated to 80-100 ℃ and boil and carry 1-4 time, each 1-4 hour, merge extractive liquid; Filter, subsequent use;
(2) 100ml propylene glycol, 6-10 gram 1-positive dodecyl aza cyclohepta-2-ketone, 60 gram salicylic acid, 30-50 gram dyclonine and 1-5 gram phenol being put into weight percent concentration is that 75% ethanol water is stirred to dissolving fully, subsequent use;
(3) solution that step (2) is obtained joins in the extracting solution that step (1) obtains, and using weight percent concentration is that 75% ethanol water is settled to 1000ml, stir afterwards, and fill, check gets product.
The function of each raw material is following with the effect brief account in the skin bacteria inhibitor provided by the invention:
Folium Artemisiae Argyi: hot, bitter, temperature.Return the liver,spleen,kidney warp.Folium Artemisiae Argyi has the effect of resisting pathogenic microbes; Oleum Folium Artemisiae Argyi wherein all has inhibitory action to streptococcus pneumoniae, golden yellow and Staphylococcus albus, Bacillus typhi etc., and the 4-terpinenol in the Oleum Folium Artemisiae Argyi can suppress the staphylococcus aureus of sensitivity and penicillin resistant bacterial strain.
Cordyceps: sweet, temperature.Return lung, kidney channel.Cordyceps has the anti-bacteria and anti-virus effect, and the Cordyceps decoct all has inhibitory action to funguses such as trichophyton mentagrophytes, acrothesium floccosum, Gypsum Fibrosum appearance microspore tinea bacterium, ulotrichy microspore's tinea bacterium.
Flos Carthami: suffering, temperature.GUIXIN, Liver Channel.Has promoting blood circulation to restore menstrual flow, the stasis-dispelling and pain-killing effect.
Radix Clematidis: hot, salty, little hardship, temperature, mild toxicity.Return bladder, Liver Channel.Radix Clematidis has anti-microbial effect, and the Radix Clematidis decoct has inhibitory action to staphylococcus aureus, shigella.Contained protoanemonin all has stronger inhibitory action to Grain-positive and negative bacteria and fungus in the Radix Clematidis.Radix Clematidis also has antiinflammation.
The Fructus Kochiae: hardship, cold.Return kidney, urinary bladder channel.Have clearing away heat-damp and promoting diuresis, the dispelling wind for relieving itching effect cures mainly dysuria, stranguria with turbid discharge, leukorrhagia, dysentery, rubella, eczema, scabies, skin pruritus, sore.The Fructus Kochiae has bacteriostasis, and rust microspore tinea bacterium, Gypsum Fibrosum appearance microspore tinea bacterium, several kinds of superficial mycosiss of being permitted blue achorion, trichophyton gypseum, acrothesium floccosum are had the obvious suppression effect.The clinical report Fructus Kochiae can effectively be treated urticaria.
Fructus Cnidii: hot, bitter, temperature.Return liver, kidney channel.Have warming the kidney to invigorate YANG, removing dampness and killing parasites, the dispelling wind for relieving itching effect cures mainly impotence in male, woman's infertility, arthralgia chiefly caused by damp pathogen lumbago, cold-damp leukorrhagia, scrotum pruritus due to damp pathogen, rheumatic arthralgia, eczema, scabies.Fructus Cnidii has anti-microbial effect, and the Fructus Cnidii aqueous extract has the broad-spectrum high efficacy bacteriostasis to escherichia coli, Penicllium chrysogenum etc.In addition, Fructus Cnidii is antipruritic in addition, anti-allergic effects.Clinically can be used for treating into human scabies and acute exudative dermatosis.
Radix Sophorae Flavescentis: hardship, cold.GUIXIN, lung, kidney, large intestine channel.Have heat clearing and damp drying, the wind dispelling insecticide function cures mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.
Radix Angelicae Sinensis: sweet, hot, temperature is returned liver, the heart, spleen channel, and enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Apply the face light speckle of can invigorating blood circulation with Radix Angelicae Sinensis, promote skin metabolism.Sun Simiao has been set forth the function of Radix Angelicae Sinensis defying age, speckle removing, beauty treatment skin and complexion improving in detail in supplement to Thousand Golden Prescriptions.
Propylene glycol: the penetration enhancer of solvent and skin absorbs.
1-positive dodecyl aza cyclohepta-2-ketone: Percutaneous absorption enhancer has advantage efficient, safety non-toxic.All there is tangible transdermal to help the effect of oozing to hydrophilic with the oleophylic medicine; Under Emulsion or colloidal state, all has the good effect of oozing that helps; It is particularly evident to various plants extracting solution, alkaloid effect, can improve the assimilation effect of skin to nutrient substance and active ingredient greatly.
Salicylic acid: be the extremely wide disinfection preservative of a kind of purposes, and can dissolve the formation thing between cutin, horny layer is produced come off, gather blocked up horny layer, enhance metabolism so can remove.Salicylic safe to use, little to the zest of skin.
Dyclonine: can block the conduction of various neural impulses or stimulation, suppress the sense of touch and the pain sensation, skin is had pain relieving, antipruritic and bactericidal action; Be a kind of pruritus that eases pain efficiently, and great bactericidal antiphlogistic effect is arranged, have rapid-action; Persistent period is of a specified duration, safe and reliable non-stimulated characteristics.Can be used for scalding, scratch, insect bite wound, hemorrhoid, ulcer, pray the pain relieving of skin ulcer, itching skin disease etc. or antipruritic.
Phenol: be corrosive, the weak solution of phenol can directly be used as the surgery disinfectant.
Weight percent concentration is that 75% ethanol water uses as solvent in skin bacteria inhibitor provided by the invention.
In skin bacteria inhibitor provided by the invention, all medicines share, to having significant antibacterial, sterilization and repair by antibacterial such as staphylococcus aureus, escherichia coli, Candida albicans or fungus-caused skin infection.Skin bacteria inhibitor of the present invention is applicable to psoriasis, neurodermatitis, eczema, seborrheic dermatitis, urticaria, solar dermatitis, prurigo, allergic dermatitis, tinea manus and pedis, discoid lupus erythematosus (DLE), systemic lupus erythematosus (sle) skin class treatment of diseases such as (SLE).Skin bacteria inhibitor of the present invention has advantage evident in efficacy, can be used for the various skin treatment of diseases, and the scope of application is wide, short treating period, and instant effect is cured the back and is difficult for recurrence, and has no side effect.
The specific embodiment
Embodiment 1
Skin bacteria inhibitor; Every liter of skin bacteria inhibitor is formed by following feedstock production: Folium Artemisiae Argyi 15 grams, Cordyceps 3 grams, Flos Carthami 6 grams, Radix Clematidis 3 grams, the Fructus Kochiae 5 grams, Fructus Cnidii 10 grams, Radix Sophorae Flavescentis 2 grams, Radix Angelicae Sinensis 3 grams, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 6 grams, salicylic acid 60 grams, dyclonine 30 grams, phenol 5 grams, all the other concentration that are weight percentage are 75% ethanol water.
The method for preparing of above-mentioned skin bacteria inhibitor may further comprise the steps:
(1) take by weighing 15 gram Folium Artemisiae Argyis, 3 gram Cordyceps, 6 gram Flos Carthamis, 3 gram Radix Clematidis, the 5 gram Fructus Kochiae, 10 gram Fructus Cnidiis, 2 gram Radix Sophorae Flavescentiss, 3 gram Radix Angelicae Sinensis, put into water afterwards and be heated to 80 ℃ and boil and carry once totally 4 hours, with the extracting liquid filtering that obtains, subsequent use afterwards;
(2) 100ml propylene glycol, 6 gram 1-positive dodecyl aza cyclohepta-2-ketone, 60 gram salicylic acid, 30 gram dyclonines and 5 gram phenol being put into weight percent concentration is that 75% ethanol water is stirred to dissolving fully, subsequent use;
(3) solution that step (2) is obtained joins in the extracting solution that step (1) obtains, and using weight percent concentration is that 75% ethanol water is settled to 1000ml, stirs afterwards, gets product, and is brown yellow transparent liquid, has Chinese medicine mixing abnormal smells from the patient.
Embodiment 2
Skin bacteria inhibitor; Every liter of skin bacteria inhibitor is formed by following feedstock production: Folium Artemisiae Argyi 18 grams, Cordyceps 2 grams, Flos Carthami 3 grams, Radix Clematidis 5 grams, the Fructus Kochiae 6 grams, Fructus Cnidii 7 grams, Radix Sophorae Flavescentis 5 grams, Radix Angelicae Sinensis 6 grams, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 10 grams, salicylic acid 60 grams, dyclonine 35 grams, phenol 2 grams, all the other concentration that are weight percentage are 75% ethanol water.
The method for preparing of above-mentioned skin bacteria inhibitor may further comprise the steps:
(1) takes by weighing 18 gram Folium Artemisiae Argyis, 2 gram Cordyceps, 3 gram Flos Carthamis, 5 gram Radix Clematidis, the 6 gram Fructus Kochiae, 7 gram Fructus Cnidiis, 5 gram Radix Sophorae Flavescentiss, 6 gram Radix Angelicae Sinensis; Put into water afterwards and be heated to 100 ℃ and boil and carry 3 times, each 2 hours, afterwards the extracting solution that obtains is merged; Filter, subsequent use;
(2) 100ml propylene glycol, 10 gram 1-positive dodecyl aza cyclohepta-2-ketone, 60 gram salicylic acid, 35 gram dyclonines and 2 gram phenol being put into weight percent concentration is that 75% ethanol water is stirred to dissolving fully, subsequent use;
(3) solution that step (2) is obtained joins in the extracting solution that step (1) obtains, and using weight percent concentration is that 75% ethanol water is settled to 1000ml, stirs afterwards, gets product, and is brown yellow transparent liquid, has Chinese medicine mixing abnormal smells from the patient.
Embodiment 3
Skin bacteria inhibitor; Every liter of skin bacteria inhibitor is formed by following feedstock production: Folium Artemisiae Argyi 20 grams, Cordyceps 1 gram, Flos Carthami 5 grams, Radix Clematidis 6 grams, the Fructus Kochiae 3 grams, Fructus Cnidii 5 grams, Radix Sophorae Flavescentis 6 grams, Radix Angelicae Sinensis 8 grams, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 8 grams, salicylic acid 60 grams, dyclonine 50 grams, phenol 1 gram, all the other concentration that are weight percentage are 75% ethanol water.
The method for preparing of above-mentioned skin bacteria inhibitor may further comprise the steps:
(1) takes by weighing 20 gram Folium Artemisiae Argyis, 1 gram Cordyceps, 5 gram Flos Carthamis, 6 gram Radix Clematidis, the 3 gram Fructus Kochiae, 5 gram Fructus Cnidiis, 6 gram Radix Sophorae Flavescentiss, 8 gram Radix Angelicae Sinensis; Put into water afterwards and be heated to 80 ℃ and boil and carry 4 times, each 1 hour, afterwards the extracting solution that obtains is merged; Filter, subsequent use;
(2) 100ml propylene glycol, 8 gram 1-positive dodecyl aza cyclohepta-2-ketone, 60 gram salicylic acid, 50 gram dyclonines and 1 gram phenol being put into weight percent concentration is that 75% ethanol water is stirred to dissolving fully, subsequent use;
(3) solution that step (2) is obtained joins in the extracting solution that step (1) obtains, and using weight percent concentration is that 75% ethanol water is settled to 1000ml, stirs afterwards, gets product, and is brown yellow transparent liquid, has Chinese medicine mixing abnormal smells from the patient.
The skin bacteria inhibitor finished product that embodiment 1～embodiment 3 is made has carried out physical and chemical testing, the pH value that records between 2.5～3.5, content of beary metal: in Pb≤1mg/kg, in As≤1mg/kg.
Adopt 2002 version " disinfection technology standard " prescriptive procedure the skin bacteria inhibitor finished product that embodiment 1～embodiment 3 makes has been carried out BA and safety testing respectively.
1, antibacterial index: to three tests of staphylococcus aureus inhibition zone diameter meansigma methods is 28.00mm; To three tests of escherichia coli inhibition zone diameter meansigma methods is 35.00mm; To three tests of Candida albicans inhibition zone diameter meansigma methods is 8.00mm.
2, safety indexes: to chmice acute per os median lethal dose(LD 50) LD
50＞5000mg/kg, true border is nontoxic.Stock solution belongs to nonirritant to rabbit skin irritant test result.
The method for using of skin bacteria inhibitor of the present invention: external is sprayed at the affected part, every day 1-2 time in right amount.
Model case
Week certain, the woman found that arm, ancon had some psoriasis punctatas to occur in 2004; Because be busy with one's work, Mrs Zhou fails to pay attention to, during to the end of the year in 2005; Psoriasis has been diffused into positions such as two arms, ancon, back; After be diagnosed as psoriasis through local hospital, effect is bad after the hospitalize of several families, has brought very big misery and mental pressure for Mrs Zhou.Bring into use skin bacteria inhibitor of the present invention treatment psoriasis in March, 2006, the 7 days Mries' Later Zhou Dynasty, one of the Five Dynasties psoriasis area has reduced 70%, after again through 7 days treatment, psoriasis disappears, psoriasis does not have recurrence so far.
2. Xue, the man, 23 years old, the cook of hotel, Beijing suffered from tinea corporis 5 years, often perspired.Just begun to find the macule of several Semen Glycines sizes, increased to first lid size later on gradually, clear-cut margin at chest; After be fused into irregular large stretch of shape each other, and have new macule to occur on every side, involve positions such as neck, oxter, abdominal part, upper arm, back at last; The surface is with the pityrosporum appearance squama of very easily peeling off on a small quantity; Lycoperdon polymorphum Vitt, brown alternately occur, shape such as piebaldism, and idol has slight scratchiness.Winter, erythra reduced, but can recur again summer.Once seen in a lot of dermatosis hospitals, but can not thoroughly dig up the roots always.Bring into use skin bacteria inhibitor of the present invention in July, 2009, through curing after the treatment of 3 time-of-weeks and not recurrence so far.
Claims (3)
1. the compositions of the skin bacteria inhibitor of an external; It is characterized in that: formed by following feedstock production: Folium Artemisiae Argyi 15-20 gram, Cordyceps 1-3 gram, Flos Carthami 3-6 gram, Radix Clematidis 3-6 gram, Fructus Kochiae 3-6 gram, Fructus Cnidii 5-10 gram, Radix Sophorae Flavescentis 2-6 gram, Radix Angelicae Sinensis 3-8 gram, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 6-10 gram, salicylic acid 60 grams, dyclonine 30-50 gram, phenol 1-5 gram, all the other concentration that are weight percentage are 75% ethanol water.
2. the compositions of the skin bacteria inhibitor of external according to claim 1; It is characterized in that: formed by following feedstock production: Folium Artemisiae Argyi 18 grams, Cordyceps 2 grams, Flos Carthami 3 grams, Radix Clematidis 5 grams, the Fructus Kochiae 6 grams, Fructus Cnidii 7 grams, Radix Sophorae Flavescentis 5 grams, Radix Angelicae Sinensis 6 grams, propylene glycol 100ml, 1-positive dodecyl aza cyclohepta-2-ketone 10 grams, salicylic acid 60 grams, dyclonine 35 grams, phenol 2 grams, all the other concentration that are weight percentage are 75% ethanol water.
3. the preparation of compositions method of the skin bacteria inhibitor of an external is characterized in that: may further comprise the steps:
(1) takes by weighing 15-20 gram Folium Artemisiae Argyi, 1-3 gram Cordyceps, 3-6 gram Flos Carthami, 3-6 gram Radix Clematidis, the 3-6 gram Fructus Kochiae, 5-10 gram Fructus Cnidii, 2-6 gram Radix Sophorae Flavescentis, 3-8 and restrain Radix Angelicae Sinensis; Put into water afterwards and be heated to 80-100 ℃ and boil and carry 1-4 time, each 1-4 hour, merge extractive liquid; Filter, subsequent use;
(2) 100ml propylene glycol, 6-10 gram 1-positive dodecyl aza cyclohepta-2-ketone, 60 gram salicylic acid, 30-50 gram dyclonine and 1-5 gram phenol being put into weight percent concentration is that 75% ethanol water is stirred to dissolving fully, subsequent use;
(3) solution that step (2) is obtained joins in the extracting solution that step (1) obtains, and using weight percent concentration is that 75% ethanol water is settled to 1000ml, stirs afterwards, gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105872624A CN102018780B (en) | 2010-12-14 | 2010-12-14 | Skin bacteriostatic agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105872624A CN102018780B (en) | 2010-12-14 | 2010-12-14 | Skin bacteriostatic agent and preparation method thereof |
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| CN102018780A CN102018780A (en) | 2011-04-20 |
| CN102018780B true CN102018780B (en) | 2012-01-25 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103341106B (en) * | 2013-07-29 | 2016-01-20 | 北京百睿宏嘉生物科技有限公司 | A kind of Cordyceps antimicrobial inflammation-relieving gel and preparation method thereof |
| CN105079507A (en) * | 2015-08-28 | 2015-11-25 | 吉林大学 | Plant antibiotics compound ointment and preparation method thereof |
| CN109999172A (en) * | 2019-05-15 | 2019-07-12 | 任海东 | A kind of Chinese medicine composition and preparation method thereof for treating ringworm of the body |
| CN110201085A (en) * | 2019-07-12 | 2019-09-06 | 张秀云 | A kind of antibacterial powder of skin repair |
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2010
- 2010-12-14 CN CN2010105872624A patent/CN102018780B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 宋兆友.常用皮肤病中药外用制剂介绍.《皮肤病与性病》.2006,第28卷(第1期), * |
| 许冰等.抗真菌中草药研究概况.《云南医药》.1984,第5卷(第1期), * |
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