CN107261087A - A kind of external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil - Google Patents
A kind of external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
Moxibustion is pressed the invention provides a kind of external application of soft tissue of joint pain assistant massaging rehabilitation to dispel pain essential oil, it includes following component：Plant Extracts from Flowers of Impatiens balsamina L, old Rhizoma Zingiberis extract, Semen Sinapis Albae extract, fructus zanthoxyli extract, old moxa extract, hot pepper seed extract, menthol, borneol, organic solvent ethanol or edible oil.It has small consumption, markedly fast, a low allergy rate, and warm presses moxibustion assistant massaging and dispels pain effect persistently, and with using the bland feature in position to human body skin.Be particularly suitable for use in human body joint caused by " wind, cold, wet, wound ", the assistant massaging of soft tissue pain disease is dispelled pain rehabilitation.
Description
Technical field
Moxibustion is pressed with a kind of external application of assistant massaging rehabilitation in field of medicaments the present invention relates to people to dispel pain essential oil formulation, tool
It is that a kind of external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil for body.
Background technology
Swelling around whole skin muscular soft tissues, four limbs joint of trunk, pain, numbness, aching and tired, activity be ineffective etc., and disease is equal
Belong to the category of traditional Chinese medicine " numbness pain ".
Traditional medical theory thinks the cause of disease of " numbness pain "：First is that extraneous " wind, cold, wet " three perverse trend is independent or heterozygosis is attacked
Human skin space between skin and muscles, four limbs joint of trunk tissue, cause gas, blood, channels and collaterals running not smooth；Second is various inside and outside masterpiece employments
Body, beyond human tissue organ's ability to bear, cause local organization organ damage " wound " and human body gas, blood, the body fluid of cause leak outside in
Qi and blood channels and collaterals are influenceed normally to run between tissue.
Traditional medical theory thinks the stage of pathology three of " numbness pain "：
First stage be " wind, cold, wet, wound " individually or heterozygosis invasion and attack human body fur skin tissue cause QI-blood circulation it is not normal,
Channels and collaterals circulation is not smooth, this stage be characterized in because lesion is shallower, pain is lighter, it is often ignored, and cannot timely rehabilitation.
Second stage be " numbness pain " over time, the change in season, the alternating of cold and heat, " wind, cold, wet, wound " again
Secondary to harass, because now tissue damaged's deficiency of vial QI is difficult to resist, perverse trend will invade skin space between skin and muscles deep layer, cause symptom to add
Weight, qi and blood coagulates puckery, and channels and collaterals are obstructed, and pain is felt bad.
Phase III is obstructed if cannot can timely and effectively develop into blockage of channel, qi and blood if rehabilitation again.It will go out
The exacerbation of symptoms, pain such as histoorgan swelling, pain, numbness, aching and tired, ineffective, the cold and hot agnosia of activity of existing corresponding site
Unbearably.
Traditional medical theory thinks that the rehabilitation of " numbness pain " should be followed " preventing diseases instead for the treatment of diseases is not controlled and disorderly controlled not disorderly "
Principle, preferably with " cream, rub, pin, moxibustion " method it is outer early control, " numbness pain " was cured in the first two stage.《The Yellow Emperor's Canon of Internal Medicine》Record, it is yellow
Supreme Being asks：Numbness or bitterly or meciless or cold or hot or wet, how is its event.Qi uncle says：More than pain person's cold air of numbness, there is cold therefore pain
, it controls Yi Jiu Ruo.
At present, clinically the external preparation of rehabilitation soft tissue pain disease mainly has：
1st, traditional Chinese medicine oil base plaster is the most frequently used external use plaster, because it boils process " pellet " must be added to receive cream, " pellet " is ore deposit
Material medicinal material contains plurality of heavy metal, so traditional oil base plaster content of beary metal is exceeded, is washed in a pan by medical management organization in recent years
Eliminate, limitation is used.
2nd, new bar cloth emplastrum is produced with modern crafts, although is solved the problems, such as heavy metals exceeding standard, but is still suffered from stickup
The defect of the toxic side effect of fine hair damage hair follicle is pulled out when local skin allergy rate is high and removes patch.
3rd, modern Western medicine external application relieves the pain gel, aqua, aerosol are because composition is single, and its drug effect under therapeutic dose
Composition is difficult to pass through skin barrier, and often therapeutic effect is not obvious.
4th, Chinese herb compound hot compress agent, is selected in promoting blood circulation and removing blood stasis, dispelling wind and eliminating dampness, softening hard masses cold dispelling with tcm theory prescription
Herbal medicine loads that cloth bag reclaimed water is boiled or cage steams after heating that hot compress pain is local, and the treatment works well, but exists using process is cumbersome, medicine
Material utilization rate is low, the defect of high cost.
Therefore, it is clinical soft tissue to research and develop new formulation for the soft tissue pain disease caused by " wind, cold, wet, wound " cause of disease
The vital task of pain rehabilitation field.
The content of the invention
Moxibustion is pressed it is an object of the invention to provide a kind of external application of soft tissue of joint pain assistant massaging rehabilitation to dispel pain essential oil,
With consumption is small, markedly fast, low allergy rate, warm presses moxibustion assistant massaging and dispels pain effect persistently, and uses position to human body skin
Bland feature.Be particularly suitable for use in human body joint caused by " wind, cold, wet, wound ", the assistant massaging of soft tissue pain disease
Pain of dispelling rehabilitation.
The present invention uses following technical scheme to achieve the above object：
A kind of external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and it includes following component：Plant phoenix
Celestial flower extract, old Rhizoma Zingiberis extract, Semen Sinapis Albae extract, fructus zanthoxyli extract, old moxa extract, hot pepper seed extract,
Menthol, borneol, organic solvent ethanol or edible oil.
The external application of described soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil comprising in each component, and its is each
The percentage range of component weight is：Extracts from Flowers of Impatiens balsamina L 2%, old Rhizoma Zingiberis extract 2%, Semen Sinapis Albae extract 2%, fructus zanthoxyli is carried
Take thing 2%, old moxa extract 2%, hot pepper seed extract 2%, menthol 0.5%, borneol 1%, its surplus be organic solvent ethanol or
Edible oil, above raw material is measured with raw medicinal herbs.
The external application of described soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its preparation method is：
1）It will be extracted 20 days with organic solvent ethanol or edible oil after the vegetable drug balsamine of recipe quantity, the pretreatment of old moxa,
Filter to get filtrate I standby；
2）Organic solvent ethanol after the old rhizoma zingiberis of the vegetable drug of recipe quantity, fructus zanthoxyli pretreatment or edible oil are extracted 20 days, mistake
Filter filtrate II is standby；
3）After the vegetable drug semen brassicae of recipe quantity, the pretreatment of hot pepper seed 20 will be extracted with organic solvent ethanol solution or edible oil
My god, filter to get filtrate III standby.
4）Stirred after I+filtrate of merging filtrate, II+filtrate III, be sequentially added into menthol, the ice of recipe quantity
Piece is stirred again makes its dissolving, stand 24 hours after filter to get filtrate IV.
5）Last precise filtrate IV, adds organic solvent ethanol or edible oil and is stirred to prescription total amount and produce
The external application of the soft tissue of joint pain assistant massaging rehabilitation of recipe quantity, which is pressed moxibustion and dispelled, aches essential oil stoste.
The external application of described soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its application method is each
0.3ML or so is applied directly to joint, soft tissue pain position.
Effect of each component raw material of the present invention is as follows：
Described vegetable drug balsamine is warm-natured, mildly bitter flavor, nontoxic.There is dispelling wind and eliminating dampness, temperature three-way meridian, lively atmosphere blood profit tendon and vessel dissipates
Effect that the stasis of blood relieves the pain.Cure mainly traumatic injury, rheumatic arthralgia, joint stuffiness.Modern pharmacological research it have suppression bactericidal, it is anti-
Scorching anti-allergic effects.
The old rhizoma zingiberis property pungent-warm of described vegetable drug, taste are peppery, nontoxic.There is warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink dissipates
Cold reason knot, the work(of dehumidifying ventilation.
Described vegetable drug semen brassicae is warm, pungent peppery, nontoxic.Have functions that dissipating bind dredging collateral relieves the pain.Cure mainly limbs fiber crops
Wood, painful swelling of joints, cloudy subcutaneous ulcer, the swollen pain of bruise.Applied to skin, there is warm sensation and rubefaction is heated up, or even cause water
Bubble.It is usually used in neuralgia treating, arthritis pain, pleurisy and bruise etc..
The old moxa pungent-warm of described vegetable drug, bitter are nontoxic.Rationale blood, by cold-dampness, warm channels and collaterals, promoting blood circulation and pain relieve.Outside
Eczema can be controlled by applying.
Described vegetable drug fructus zanthoxyli gas is fragrant and pungent peppery, there is middle benefit gas promoting the circulation of qi, by it is cold relieve the pain, desinsection the effects such as.It can do
Epidermis anesthetic.
Described vegetable drug hot pepper seed warming spleen and stomach for dispelling cold, lower gas help digestion；External application treating chilblain, rheumatalgia, psoas pain etc..
Described menthol, white crystal, molecular formula C10H20O, is the main component in peppermint and lavender essential oil.
Pharmaceutically it is used as excitants, acts on skin or mucous membrane, there is refrigerant itching-relieving action.
Described borneol, gas delicate fragrance is pungent, tepor, nontoxic.Borneol easily absorbs through mucous membrane, skin histology, is that one kind has
The skin penetration enhancer of effect.Extremities joint, skeleton pain can be treated.With antimicrobial antiphlogistic and analgesic activity.
Described organic solvent ethanol is colourless transparent liquid, has wine aroma.
Described edible oil for it is faint yellow to amber transparent liquid, have aroma.It is the important of safe without toxic side effect
Organic solvent.
The present invention is had the advantages that using above-mentioned technical proposal：
1st, the external application of soft tissue of joint pain assistant massaging rehabilitation of the present invention presses moxibustion and dispels pain essential oil from meeting the requirements
Food grade, pharmaceutical grade, natural vegetable Chinese herbal medicine material extraction thing compounding be made, it is safe and reliable without chemical synthetic material.
2nd, the external application of soft tissue of joint pain assistant massaging rehabilitation of the present invention is pressed moxibustion and dispelled and aches in essential oil prescription
Plant balsamine, old moxa modern pharmacological research prove that it has suppression bactericidal, anti-inflammatory anti-allergic effects, greatly reduce smearing and use
Allergic rate after medicine.
3rd, the external application of soft tissue of joint pain assistant massaging rehabilitation of the present invention, which is pressed moxibustion and dispelled, aches choosing in essential oil prescription
With warm-natured, heat, the pungent old rhizoma zingiberis of peppery plant, semen brassicae, fructus zanthoxyli, hot pepper seed extract are applied to skin surface, pass through thorn
Swash skin produce it is warm feel to cause rubefaction to heat up, the warm for playing similar moxa-moxibustion presses moxibustion physiotheraping effect, reaches and drives
The physiotherapy purpose that wind-cold damp pathogen is reversely excreted from the soft tissue position of lesion by pore.
4th, the external application of soft tissue of joint pain assistant massaging rehabilitation of the present invention, which is pressed moxibustion and dispelled, aches choosing in essential oil prescription
It is set to promote the effect of active ingredient Transdermal absorption to form synergistic effect with plant fructus zanthoxyli and menthol, borneol compatibility application,
The epidermis anesthetic effect of the compositions such as fructus zanthoxyli is played to greatest extent, is made its antimicrobial antiphlogistic analgesic effect formation rapid superposition, is reached
To the therapeutic effect relieved the pain rapidly.
5th, the external application of soft tissue of joint pain assistant massaging rehabilitation of the present invention presses moxibustion and dispels pain essential oil rationally,
Extraction process of effective component, manufacture craft are unique, purity is big, content is high, material are saved, while product consumption is small, markedly fast, effect
Really good, economic benefit is obvious.
6th, the external application of soft tissue of joint pain assistant massaging rehabilitation of the present invention, which is pressed moxibustion and dispelled, aches essential oil laboratory reality
Checking is bright, and its stability is good, and multiple skin irritatin toxicological experiment proves small to skin irritation, safe.It is particularly suitable for use in
Human body joint caused by " wind, cold, wet, wound ", the assistant massaging of soft tissue pain disease are dispelled pain rehabilitation.It can also be applied to simultaneously
The rehabilitation of non-diabrosis skin soft tissue bacterium infection and mosquito bite and insect bite disease.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
The external application of described soft tissue of joint pain assistant massaging rehabilitation press moxibustion dispel pain essential oil include each component in, its each component
Weight percentage ranges are：Extracts from Flowers of Impatiens balsamina L 2%, old Rhizoma Zingiberis extract 2%, Semen Sinapis Albae extract 2%, fructus zanthoxyli extract 2%,
Old moxa extract 2%, hot pepper seed extract 2%, menthol 0.5%, borneol 1%, its surplus is organic solvent ethanol, above raw material
Measured with raw medicinal herbs.
The external application of described soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its preparation method is：
1）Organic solvent alcohol steep will be used after the vegetable drug balsamine of recipe quantity, the pretreatment of old moxa 20 days, filtering to filter
Liquid I is standby；
2）Organic solvent alcohol steep will be used after the old rhizoma zingiberis of the vegetable drug of recipe quantity, fructus zanthoxyli pretreatment 20 days, filtering to filter
Liquid II is standby；
3）It will be extracted 20 days with organic solvent ethanol solution after the vegetable drug semen brassicae of recipe quantity, the pretreatment of hot pepper seed, filtering
Obtain filtrate III standby；
4）Stirred after I+filtrate of merging filtrate, II+filtrate III, be sequentially added into the menthol of recipe quantity, borneol again
Stirring dissolves it, and IV is filtered to get filtrate after standing 24 hours；
5）Precise filtrate IV, adds organic solvent ethanol to prescription total amount and stirs and produce soft group of the joint of recipe quantity
Knit pain assistant massaging rehabilitation external application press moxibustion dispel pain essential oil stoste.
The external application of described soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its application method is each
0.3ML or so directly smears skin soft tissue, arthralgia position.After smearing with 3-5 minutes effects of manual massage more
It is good.
Product obtained by extracting above example 1 is detected that specific testing result is as follows：
Microorganism pollution is detected in the sample of 1 embodiment 1：
The total number of bacterial colonies of the product, coliform, staphylococcus aureus, Pseudomonas aeruginosa, hemolytic streptococcus, fungi bacterium
Fall sum to meet《Disinfection technology standard》（Version in 2002）Regulation.Detailed data is as follows.
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches essential oil microorganism pollution testing result
| Testing index | Standard value | Measured value |
| Total number of bacterial colonies | ≤200 cfu/g | <20 cfu/g |
| Coliform | It must not detect | Do not detect |
| Staphylococcus aureus | It must not detect | Do not detect |
| Pseudomonas aeruginosa | It must not detect | Do not detect |
| Hemolytic streptococcus | It must not detect | Do not detect |
| Fungus colony sum | ≤100 cfu/g | <20 cfu/g |
The sample fungistatic effect of 2 embodiment 1 is determined as follows：
2.1 staphylococcus aureus bacteriostatic tests
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To staphylococcus aureus bacteriostatic test result
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to three experiment suppressions of staphylococcus aureus
Collarium diameter average value is 20.18mm, there is bacteriostasis.
2.2 Escherichia coli bacteriostatic tests
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To Escherichia coli bacteriostatic test result
Conclusion：
It is straight to the experiment antibacterial ring sizes of Escherichia coli three times that moxibustion pain essential oil of dispelling is pressed in the external application of soft tissue of joint pain assistant massaging rehabilitation
Footpath average value is 18.99mm, there is bacteriostasis.
2.3 Candida albicans bacteriostatic tests
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To Candida albicans bacteriostatic test result
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to three experiment antibacterial ring sizes of Candida albicans
Diameter average value is 16.54m, there is bacteriostasis.
The sample stability of 3 embodiment 1 is detected（2 years）.（The same batch of " 2.3 Candida albicans bacteriostatic test " will be done
Sample does detection experiment）
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches essential oil stability test result
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches after essential oil is preserved 90 days at 37 DEG C to Candida albicans
Three experiment inhibition zone diameter average values of bacterium are 13.23mm, have bacteriostasis, storage life can be set to 2 years.
The sample toxicity of 4 embodiment 1 --- multiple intact skin stimulation test detection：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to the multiple Skin Irritation Test of rabbit
Average every animal integral mean value daily is 0
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to the reaction of rabbit multiple Skin Irritation Test
Integral mean value is " 0 " foundations《Disinfection technology standard》（Version in 2002）Skin irritatin strength grading evaluation criterion judges：Joint is soft
The external application of tissue irritation disease assistant massaging rehabilitation press moxibustion dispel pain essential oil non-stimulated is belonged to the multiple Skin Irritation Test of rabbit.
Embodiment 2
The external application of described soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil formulation comprising in each component, and its is each
The percentage range of component weight is：Plant Extracts from Flowers of Impatiens balsamina L 2%（In terms of raw medicinal herbs）, old Rhizoma Zingiberis extract 2%（With raw medicinal herbs
Meter）, Semen Sinapis Albae extract 2%（In terms of raw medicinal herbs）, fructus zanthoxyli extract 2%（In terms of raw medicinal herbs）, old moxa extract 2g%（With
Raw medicinal herbs meter）, hot pepper seed extract 2g%（In terms of raw medicinal herbs）, menthol 0.5%, borneol 1%, its surplus is edible oil.
The external application of described soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its preparation method is：
1）It will be extracted 20 days, filtered to get filtrate I standby with edible oil after the vegetable drug balsamine of recipe quantity, the pretreatment of old moxa
With；
2）It will be extracted 20 days, filtered to get filtrate II standby with edible oil after the old rhizoma zingiberis of the vegetable drug of recipe quantity, fructus zanthoxyli pretreatment
With；
3）It will be extracted 20 days, filtered to get filtrate III standby with edible oil after the vegetable drug semen brassicae of recipe quantity, the pretreatment of hot pepper seed
With；
4）Stirred after I+filtrate of merging filtrate, II+filtrate III, be sequentially added into the menthol of recipe quantity, borneol again
Stirring dissolves it, and IV is filtered to get filtrate after standing 24 hours；
5）Precise filtrate IV, adds edible oil to prescription total amount and stirs and produce the soft tissue of joint pain of recipe quantity
The external application of disease assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches essential oil stoste.
The external application of described soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its application method is each
0.3ML or so directly smears skin soft tissue, arthralgia position.After smearing with 3-5 minutes effects of manual massage more
It is good.
Product obtained by extracting above example 2 is detected that specific testing result is as follows：
Microorganism pollution is detected in the sample of 1 embodiment 2：
The total number of bacterial colonies of the product, coliform, staphylococcus aureus, Pseudomonas aeruginosa, hemolytic streptococcus, fungi bacterium
Fall sum to meet《Disinfection technology standard》（Version in 2002）Regulation.Detailed data is as follows：
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches essential oil microorganism pollution testing result
| Testing index | Standard value | Measured value |
| Total number of bacterial colonies | ≤200 cfu/g | <20 cfu/g |
| Coliform | It must not detect | Do not detect |
| Staphylococcus aureus | It must not detect | Do not detect |
| Pseudomonas aeruginosa | It must not detect | Do not detect |
| Hemolytic streptococcus | It must not detect | Do not detect |
| Fungus colony sum | ≤100 cfu/g | <20 cfu/g |
The sample fungistatic effect of 2 embodiment 2 is determined as follows：
2.1 staphylococcus aureus bacteriostatic tests
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To staphylococcus aureus bacteriostatic test result
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to three experiment suppressions of staphylococcus aureus
Collarium diameter average value is 16.16mm, there is bacteriostasis.
2.2 Escherichia coli bacteriostatic tests
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To Escherichia coli bacteriostatic test result
Conclusion：
It is straight to the experiment antibacterial ring sizes of Escherichia coli three times that moxibustion pain essential oil of dispelling is pressed in the external application of soft tissue of joint pain assistant massaging rehabilitation
Footpath average value is 10.09mm, there is bacteriostasis.
2.3 Candida albicans bacteriostatic tests
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To Candida albicans bacteriostatic test result
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to three experiment antibacterial ring sizes of Candida albicans
Diameter average value is 7.86mm, there is bacteriostasis.
The Samples EXAMPLE sample stability of 3 embodiment 2 is detected：（The same of " 2.3 Candida albicans bacteriostatic test " will be done
Batch sample does detection experiment）
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches essential oil stability test result
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches after essential oil is preserved 90 days at 37 DEG C to Candida albicans
Three experiment inhibition zone diameter average values of bacterium are 7.28mm, have bacteriostasis, storage life can be set to 2 years.
The sample toxicity of 4 embodiment 2 --- multiple intact skin stimulation test detection：
The external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil
To the multiple intact skin irritant test of rabbit
Average every animal integral mean value daily is 0
Conclusion：
The external application of soft tissue of joint pain assistant massaging rehabilitation presses moxibustion and dispels pain essential oil to the reaction of rabbit multiple Skin Irritation Test
Integral mean value is " 0 " foundations《Disinfection technology standard》（Version in 2002）Skin irritatin strength grading evaluation criterion judges：Joint is soft
The external application of tissue irritation disease assistant massaging rehabilitation press moxibustion dispel pain essential oil non-stimulated is belonged to the multiple Skin Irritation Test of rabbit.
Claims (3)
1. a kind of external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, it is characterised in that：It is included down
Row component：Plant Extracts from Flowers of Impatiens balsamina L, old Rhizoma Zingiberis extract, Semen Sinapis Albae extract, fructus zanthoxyli extract, old moxa extract,
Hot pepper seed extract, menthol, borneol, organic solvent ethanol or edible oil.
2. a kind of external application of soft tissue of joint pain assistant massaging rehabilitation according to claim 1 is pressed moxibustion and dispelled pain essential oil,
It is characterized in that：It is comprising percentage range of each component weight：Extracts from Flowers of Impatiens balsamina L 2%, old Rhizoma Zingiberis extract 2%, sinapsis alba
Seed extract 2%, fructus zanthoxyli extract 2%, old moxa extract 2%, hot pepper seed extract 2%, menthol 0.5%, borneol 1%, its
Surplus is organic solvent ethanol or edible oil, and above raw material is measured with raw medicinal herbs.
3. a kind of external application of soft tissue of joint pain assistant massaging rehabilitation according to claim 2 is pressed moxibustion and dispelled pain essential oil,
It is characterized in that：
The described external application for soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil, and its preparation method is：
1）It will be extracted 20 days with organic solvent ethanol or edible oil after the vegetable drug balsamine of recipe quantity, the pretreatment of old moxa,
Filter to get filtrate I standby；
2）It will be extracted 20 days with organic solvent ethanol or edible oil after the old rhizoma zingiberis of the vegetable drug of recipe quantity, fructus zanthoxyli pretreatment,
Filter to get filtrate II standby；
3）After the vegetable drug semen brassicae of recipe quantity, the pretreatment of hot pepper seed 20 will be extracted with organic solvent ethanol solution or edible oil
My god, filter to get filtrate III standby；
4）Stirred after I+filtrate of merging filtrate, II+filtrate III, be sequentially added into the menthol of recipe quantity, borneol again
Stirring dissolves it, and IV is filtered to get filtrate after standing 24 hours；
5）Precise filtrate IV, adds organic solvent ethanol or edible oil and is stirred to prescription total amount and produce recipe quantity
The external application of soft tissue of joint pain assistant massaging rehabilitation, which is pressed moxibustion and dispelled, aches essential oil stoste.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115969948A (en) * | 2021-10-15 | 2023-04-18 | 湖北万松堂大健康医药集团有限公司 | Dampness-clearing navel plaster formula and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115969948A (en) * | 2021-10-15 | 2023-04-18 | 湖北万松堂大健康医药集团有限公司 | Dampness-clearing navel plaster formula and preparation method thereof |
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Application publication date: 20171020 |