CN103213226A - Preparation method of antisepsis and anti-inflammation lubrication-type condom containing natural cinnamyl aldehyde - Google Patents
Preparation method of antisepsis and anti-inflammation lubrication-type condom containing natural cinnamyl aldehyde Download PDFInfo
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- CN103213226A CN103213226A CN2013101607534A CN201310160753A CN103213226A CN 103213226 A CN103213226 A CN 103213226A CN 2013101607534 A CN2013101607534 A CN 2013101607534A CN 201310160753 A CN201310160753 A CN 201310160753A CN 103213226 A CN103213226 A CN 103213226A
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Abstract
The invention relates to a preparation method of an antisepsis and anti-inflammation lubrication-type condom containing natural cinnamyl aldehyde. The preparation method of the antisepsis and anti-inflammation lubrication-type condom containing natural cinnamyl aldehyde particularly comprises the following steps of: coating cinnamyl aldehyde directly on a natural emulsion condom or butyronitrile emulsion condom finished product, or adding and dispersing a certain amount of cinnamyl aldehyde together with other conventional burdening uniformly into the natural emulsion or butyronitrile emulsion in raw material prevulcanization process of the natural emulsion condom or the butyronitrile emulsion condom; then steeping and forming a natural emulsion glove condom or a butyronitrile emulsion condom which comprises natural cinnamyl aldehyde by a conventional forming technology; and then performing edge curling, chloridizing, foam-washing, rinsing and drying, thereby obtaining a finished product. The condom prepared by the method has the function of antisepsis and anti-inflammation, lubricating and skin protection; and meanwhile cinnamyl aldehyde can emit fragrant flavor, and can eliminate peculiar smell secreted by human bodies, is simple in technology, is low in cost, also saves resources, and improves the production efficiency.
Description
Technical field
The present invention relates to the preparation method of sheath, particularly a kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricant sheath belongs to daily hygiene articles for use preparing technical field.
Background technology
Point out that according to the up-to-date report of the World Health Organization whole world had 2,500,000 people newly to infect AIDS virus in 2011, estimated at 1,700,000 people's death, infect number than global New Development before 10 years and reduced 700,000 that the death toll than 2005 has reduced 600,000." China's AIDS prevent and treat joint assessment report " pointed out, China's accumulative total is reported patients infected hiv and AIDS patient's 223501 examples in by the end of October, 2007 by, AIDS patient's 62838 examples wherein, dead report 22205 examples.Sheath prevents pregnancy as the form with non-medicine, and in addition, sheath also has the effect of the gonorrhoea of preventing, AIDS spread of sexually transmitted diseases such as (HIV), therefore also claims condom.Present sheath raw material is normally with natural rubber or polyurethane, they can only be used for contraception and shielding virus, can not play antibiotic effectively and effect anti-inflammatory, therefore the product of developing the quality high-quality is directly connected to the public's healthy and safety, more and more is subjected to the attention of relevant government department.
Along with security needs, beginning is added Chinese medicine as bactericide in sheath, a kind of traditional Chinese medicine bactericide sheath is disclosed as CN1348746A, be after Chinese medicine extract is added moisturizing agent and tackifier mixing, join inside and outside the sheath, the traditional Chinese medicinal components of its Chinese medicine bactericidal liquid is: kuh-seng, frutus cnidii, Lappula echinata grass, the fruit of summer cypress, Radix Angelicae Sinensis, golden cypress, pericarpium zanthoxyli, betel nut, schizonepeta, the root of langdu etc.The present invention adopts cinnamic acid as the anti-inflammation material, and is with low cost, better effects if.
Chinese cassia tree (
Cinnamomum cassiaPresl) be a kind of important Chinese herbal medicine, have that to mend fire supporing yang, eliminating cold to stop pain, the function of warming meridian is used for the treatment of impotence, frequent micturition, postpartum the retention of urine, cirrhotic ascites, asthma, Bronchopneumonia, aphtha, baby diarrhea, children's hernia, rheumatism etc.In the Chinese cassia tree except that containing some carbohydrate, also contain abundant cinnamon oil, its main component is a cinnamic acid, it is anticorrosion that cinnamic acid has a sterilizing, particularly fungi there is significant curative effect, Escherichia coli, hay bacillus and golden yellow staphylococcus, staphylococcus albus, Shigella shigae, typhoid fever and paratyphoid A bacillus, pneumococcus, aerobacteria, proteus, bacillus anthracis, Bacterium enteritidis, comma bacillus etc. there is inhibitory action, and remarkable to the gram-positive bacteria bactericidal effect, can be used for treating the multiple disease that causes because of bacterial infection.Its MIC (MIC) is 0.02-0.07ul/ml, and to the deep pathomycete, MIC is 0.1-0.3ul/ml.
At present Researches on Cinnamomum cassia Presl is mainly concentrated on the medical science pharmacology, Japan medical science the expert discover, cinnamic acid has significant curative effect to fungi, studies show that by 22 kinds of condition pathogenic funguses are carried out STUDY ON ANTIFUNGAL EFFECT OF CINNAMYL ALDEHYDE: cinnamic acid is antimycotic active material, mainly be by destroying fungal cell wall, medicine is infiltrated in the fungal cell, destroy organelle and play bactericidal action.
The present invention improves its solubility earlier with cinnamic acid emulsification, strengthens drug effect and bioavilability, has improved sulfuration efficient; Join the effect that to play anti-inflammation in the sheath; And China's Chinese cassia tree aboundresources output accounts for more than 80% of world's Chinese cassia tree output, and Guangdong, Guangxi two province's Chinese cassia tree output account for more than 95% of China's Chinese cassia tree output, for the exploitation and the rational and effective utilization of resource provides approach.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method who contains natural meat cinnamic aldehyde sheath, the sheath of preparation can play the function of anti-inflammation and lubricated skin care.
In order to address the above problem, the technical solution adopted in the present invention is:
A kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath comprises:
(1) on natural emulsion sheath or NBR latex sheath finished product, directly applies cinnamic acid through Over emulsfication;
(2) in producing natural emulsion sheath or the employed raw material of NBR latex sheath, add cinnamic acid through Over emulsfication.
The cinnamic acid that adds in raw material described in the said method (2) is meant in the raw material presulfurization operation of conventional natural emulsion sheath or NBR latex sheath, a certain amount of cinnamic acid is added equably together with other conventional batchings and be distributed in natural emulsion or the NBR latex, moulding process floods natural emulsion gloves sheath or the NBR latex sheath that becomes to contain the natural meat cinnamic aldehyde routinely again, then by crimping, chlorination, bubble wash, rinsing, drying process obtain finished product.
The mass ratio of wherein said cinnamic acid and rubber is preferably 0.5 ~ 1.5:100; Preferred mass ratio is 0.8:100 or 1.2:100.
For better implement the present invention, described cinnamic acid need be prepared into the emulsified meat cinnamic aldehyde earlier, concrete grammar is: add 0.5g polyvinyl alcohol (PVA-1788) and 0.1g sodium alginate in the three-necked bottle of 250mL, 100mL distilled water, heating for dissolving is 2 hours under stirring, be chilled to room temperature, add 3g polyethylene glycol-200 and be dissolved in the 10ml aqueous solution, after the constant temperature stirring and emulsifying 10 minutes, ice bath drips 1.28g IPDI (IPDI) down, 10.0g the mixture of cinnamic acid and 3g acetone, the control mixing speed is about 1500rpm, dripping complete back continues to stir 30 minutes under ice bath, ultrasonic refinement 15 minutes, obtain faint yellow emulsion product, promptly get the emulsified meat cinnamic aldehyde, can arbitrary proportion miscible.
In a preferred embodiment, the deal of the mixture of described rubber and cinnamic acid and vulcanizing agent, activating agent is counted with mass parts:
100 parts in the mixture of rubber and cinnamic acid
3 ~ 7 parts of vulcanizing agents
5 ~ 10 parts of activating agents.
Wherein, the deal of the mixture of described rubber and cinnamic acid and vulcanizing agent, activating agent is counted with mass parts:
100 parts in the mixture of rubber and cinnamic acid
5 parts of vulcanizing agents
8 parts of activating agents.
In another preferred embodiment, be that 50 ~ 80 ℃ of ultrasonic agitation are handled in temperature during mixing, the time is 20 ~ 50 minutes.In another preferred embodiment, temperature is 40 ~ 70 ℃ during sulfuration, and the time is 1 ~ 2 hour
The invention has the beneficial effects as follows:
(1) the present invention is by adding the emulsified meat cinnamic aldehyde in the raw material presulfurization operation of conventional natural emulsion sheath or NBR latex sheath, make in the sheath after cinnamic acid is distributed in moulding equably, during wearing, cinnamic acid in the sheath can constantly be separated and act on skin, play the function of anti-inflammation and lubricated skin care, cinnamic acid can also give out the smell of delicate fragrance simultaneously, eliminates the peculiar smell of human secretory.
(2) technology of the present invention is simple, and is easy to operate, raw material with low cost, and improved rate of cure, and reducing the raw material consumption, the performance of product meets request of national standard.
The specific embodiment:
Below by embodiment the present invention is described in further details, these embodiment only are used for illustrating the present invention, do not limit the scope of the invention.
Cinnamic acid is prepared into the emulsified meat cinnamic aldehyde, concrete grammar is: add 0.5g polyvinyl alcohol (PVA-1788) and 0.1g sodium alginate in the three-necked bottle of 250mL, 100mL distilled water, heating for dissolving is 2 hours under stirring, be chilled to room temperature, add 3g polyethylene glycol-200 and be dissolved in the 10ml aqueous solution, after the constant temperature stirring and emulsifying 10 minutes, ice bath drips 1.28g IPDI (IPDI) down, 10.0g the mixture of cinnamic acid and 3g acetone, the control mixing speed is dripped complete back and is continued to stir 30 minutes under ice bath about 1500rpm, ultrasonic refinement 15 minutes obtains faint yellow emulsion product, promptly get the emulsified meat cinnamic aldehyde, can arbitrary proportion miscible.
Embodiment 1
(1) is equipped with 100 parts of rubber, 0.8 part of cinnamic acid, 5 parts of vulcanizing agents, 7 parts of activating agents;
(2) rubber and cinnamic acid are mixed, add vulcanizing agent and activating agent again;
(3) be that 50 ℃ of ultrasonic agitation are handled in temperature, the time is 50 minutes;
(4) back is 40 ℃ of sulfurations 2.0 hours in temperature;
(5) then by crimping, chlorination, bubble wash, rinsing, drying process can obtain finished product.
Embodiment 2
(1) is equipped with 100 parts of rubber, 1.2 parts of cinnamic acids, 6 parts of vulcanizing agents, 5 parts of activating agents;
(2) rubber and cinnamic acid are mixed, add vulcanizing agent and activating agent again;
(3) be that 60 ℃ of ultrasonic agitation are handled in temperature, the time is 35 minutes;
(4) back is 50 ℃ of sulfurations 1.5 hours in temperature;
(5) then by crimping, chlorination, bubble wash, rinsing, drying process can obtain finished product.
Embodiment 3
(1) is equipped with 100 parts of rubber, 0.5 part of cinnamic acid, 3 parts of vulcanizing agents, 8 parts of activating agents;
(2) rubber and cinnamic acid are mixed, add vulcanizing agent and activating agent again;
(3) be that 70 ℃ of ultrasonic agitation are handled in temperature, the time is 25 minutes;
(4) back is 60 ℃ of sulfurations 1.0 hours in temperature;
(5) then by crimping, chlorination, bubble wash, rinsing, drying process can obtain finished product.
Embodiment 4
(1) is equipped with 100 parts of rubber, 1.5 parts of cinnamic acids, 7 parts of vulcanizing agents, 10 parts of activating agents;
(2) rubber and cinnamic acid are mixed, add vulcanizing agent and activating agent again;
(3) be that 80 ℃ of ultrasonic agitation are handled in temperature, the time is 20 minutes;
(4) back is 70 ℃ of sulfurations 0.8 hour in temperature;
(5) then by crimping, chlorination, bubble wash, rinsing, drying process can obtain finished product.
Embodiment 5
A certain amount of emulsified meat cinnamic aldehyde directly is coated on the sheath.
Claims (10)
1. preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath is characterized in that:
(1) on natural emulsion sheath or NBR latex sheath finished product, directly applies cinnamic acid through Over emulsfication;
(2) in producing natural emulsion sheath or the employed raw material of NBR latex sheath, add cinnamic acid through Over emulsfication.
2. one kind contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath with the preparation of the described method of claim 1.
3. a kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath according to claim 1, it is characterized in that: the cinnamic acid that adds in raw material described in the method (2) is meant in the raw material presulfurization operation of conventional natural emulsion sheath or NBR latex sheath, a certain amount of cinnamic acid is added equably together with other conventional batchings and be distributed in natural emulsion or the NBR latex, moulding process floods natural emulsion gloves sheath or the NBR latex sheath that becomes to contain the natural meat cinnamic aldehyde routinely again, passes through crimping then, chlorination, bubble is washed, rinsing, drying process obtains finished product.
4. a kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath according to claim 1, it is characterized in that: the mass ratio of described cinnamic acid and rubber is 0.5 ~ 1.5:100.
5. according to claim 1 or 4 described a kind of preparation methods that contain natural meat cinnamic aldehyde anti-inflammation lubricating type sheath, it is characterized in that: the mass ratio of described cinnamic acid and rubber is 0.8:100 or 1.2:100.
6. a kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath according to claim 1, it is characterized in that: the emulsification concrete grammar of described emulsified meat cinnamic aldehyde is: add 0.5g PVAC polyvinylalcohol-1788 and 0.1g sodium alginate in the three-necked bottle of 250mL, 100mL distilled water, heating for dissolving is 2 hours under stirring, be chilled to room temperature, add 3g polyethylene glycol-200 and be dissolved in the 10ml aqueous solution, after the constant temperature stirring and emulsifying 10 minutes, ice bath drips 1.28g IPDI (IPDI) down, 10.0g the mixture of cinnamic acid and 3g acetone, the control mixing speed is about 1500rpm, dripping complete back continues to stir 30 minutes under ice bath, ultrasonic refinement 15 minutes, obtain faint yellow emulsion product, promptly get the emulsified meat cinnamic aldehyde.
7. a kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath according to claim 3, it is characterized in that: the deal of the mixture of described rubber and cinnamic acid and vulcanizing agent, activating agent is counted with mass parts:
100 parts in the mixture of rubber and cinnamic acid
3 ~ 7 parts of vulcanizing agents
5 ~ 10 parts of activating agents.
8. a kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath according to claim 3, it is characterized in that: the deal of the mixture of (2) described rubber and cinnamic acid and vulcanizing agent, activating agent is counted with mass parts:
100 parts in the mixture of rubber and cinnamic acid
5 parts of vulcanizing agents
8 parts of activating agents.
9. according to claim 7 or 8 described a kind of preparation methods that contain natural meat cinnamic aldehyde anti-inflammation lubricating type sheath, it is characterized in that: be that ultrasonic agitation is handled under 50 ~ 80 ℃ of conditions in temperature during mixing, the time is 20 ~ 50 minutes.
10. according to the mixture of claim 7 or 8 described rubber and cinnamic acid and vulcanizing agent, activating agent, it is characterized in that: temperature is 40 ~ 70 ℃ during sulfuration, and the time is 1 ~ 2 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310160753.4A CN103213226B (en) | 2013-05-06 | 2013-05-06 | A kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310160753.4A CN103213226B (en) | 2013-05-06 | 2013-05-06 | A kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath |
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| CN103213226A true CN103213226A (en) | 2013-07-24 |
| CN103213226B CN103213226B (en) | 2016-05-25 |
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| CN201310160753.4A Expired - Fee Related CN103213226B (en) | 2013-05-06 | 2013-05-06 | A kind of preparation method who contains natural meat cinnamic aldehyde anti-inflammation lubricating type sheath |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445903A (en) * | 2013-09-25 | 2013-12-18 | 桂林恒保健康用品有限公司 | Condom capable of treating chronic pelvic inflammation |
| CN103445905A (en) * | 2013-09-25 | 2013-12-18 | 桂林恒保健康用品有限公司 | Condom capable of treating gynecological inflammations |
| CN108366871A (en) * | 2015-12-21 | 2018-08-03 | 乐福思健康有限公司 | Coating sheath |
| CN112812385A (en) * | 2021-01-15 | 2021-05-18 | 威乐士医疗卫生用品（湖北）有限公司 | Preparation method of latex condom |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH07289575A (en) * | 1994-04-27 | 1995-11-07 | Okamoto Ind Inc | Rerfume-added condom and method for adding perfume to condom |
| CN1191130A (en) * | 1997-02-18 | 1998-08-26 | 雷学军 | Anti-AIDS virus, anti-Treponema pallidum, anti-gonococcus, anti-candida albicans and anti-trichomonas natural drug |
| CN1348746A (en) * | 2000-10-13 | 2002-05-15 | 郭晓勤 | Condom with Chinese medicine bactericide |
| CN101596131A (en) * | 2009-06-18 | 2009-12-09 | 周政明 | A kind of condom containing antibacterial and antiviral medicine and preparation method thereof |
| CN101974174A (en) * | 2010-10-22 | 2011-02-16 | 中国热带农业科学院农产品加工研究所 | Method for preparing sterilization and inflammation reducing condom containing natural aloe extract |
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2013
- 2013-05-06 CN CN201310160753.4A patent/CN103213226B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07289575A (en) * | 1994-04-27 | 1995-11-07 | Okamoto Ind Inc | Rerfume-added condom and method for adding perfume to condom |
| CN1191130A (en) * | 1997-02-18 | 1998-08-26 | 雷学军 | Anti-AIDS virus, anti-Treponema pallidum, anti-gonococcus, anti-candida albicans and anti-trichomonas natural drug |
| CN1348746A (en) * | 2000-10-13 | 2002-05-15 | 郭晓勤 | Condom with Chinese medicine bactericide |
| CN101596131A (en) * | 2009-06-18 | 2009-12-09 | 周政明 | A kind of condom containing antibacterial and antiviral medicine and preparation method thereof |
| CN101974174A (en) * | 2010-10-22 | 2011-02-16 | 中国热带农业科学院农产品加工研究所 | Method for preparing sterilization and inflammation reducing condom containing natural aloe extract |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445903A (en) * | 2013-09-25 | 2013-12-18 | 桂林恒保健康用品有限公司 | Condom capable of treating chronic pelvic inflammation |
| CN103445905A (en) * | 2013-09-25 | 2013-12-18 | 桂林恒保健康用品有限公司 | Condom capable of treating gynecological inflammations |
| CN103445903B (en) * | 2013-09-25 | 2015-05-13 | 桂林恒保健康用品有限公司 | Condom capable of treating chronic pelvic inflammation |
| CN108366871A (en) * | 2015-12-21 | 2018-08-03 | 乐福思健康有限公司 | Coating sheath |
| CN112812385A (en) * | 2021-01-15 | 2021-05-18 | 威乐士医疗卫生用品（湖北）有限公司 | Preparation method of latex condom |
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| CN103213226B (en) | 2016-05-25 |
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