CN103212112A - Antibacterial and inflammation preventing lubricating catheter containing natural cinnamyl aldehyde and preparation method thereof - Google Patents
Antibacterial and inflammation preventing lubricating catheter containing natural cinnamyl aldehyde and preparation method thereof Download PDFInfo
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- CN103212112A CN103212112A CN201310160713XA CN201310160713A CN103212112A CN 103212112 A CN103212112 A CN 103212112A CN 201310160713X A CN201310160713X A CN 201310160713XA CN 201310160713 A CN201310160713 A CN 201310160713A CN 103212112 A CN103212112 A CN 103212112A
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- cinnamic aldehyde
- latex
- catheter
- inflammation
- silica gel
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- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 title claims abstract description 73
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 230000001050 lubricating effect Effects 0.000 title claims abstract description 14
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 7
- 230000003405 preventing effect Effects 0.000 title abstract description 4
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 239000004816 latex Substances 0.000 claims abstract description 29
- 229920000126 latex Polymers 0.000 claims abstract description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000000741 silica gel Substances 0.000 claims abstract description 19
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 19
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 5
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 67
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 67
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims description 66
- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 235000013372 meat Nutrition 0.000 claims description 27
- 230000003213 activating effect Effects 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 229920001296 polysiloxane Polymers 0.000 claims description 14
- 238000000465 moulding Methods 0.000 claims description 10
- 229920001971 elastomer Polymers 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000013019 agitation Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 238000006424 Flood reaction Methods 0.000 claims description 2
- 239000005058 Isophorone diisocyanate Substances 0.000 claims 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000007598 dipping method Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000005461 lubrication Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 238000005987 sulfurization reaction Methods 0.000 description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 208000019206 urinary tract infection Diseases 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 235000019082 Osmanthus Nutrition 0.000 description 3
- 241000333181 Osmanthus Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000003708 urethra Anatomy 0.000 description 3
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 2
- 241000228197 Aspergillus flavus Species 0.000 description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 125000002871 cinnamic aldehydes group Chemical group 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- JRJGKUTZNBZHNK-UHFFFAOYSA-N 3-phenylpropyl acetate Chemical compound CC(=O)OCCCC1=CC=CC=C1 JRJGKUTZNBZHNK-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000008718 Pyuria Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Abstract
The invention relates to a preparation method of an antibacterial and inflammation preventing lubricating catheter containing natural cinnamyl aldehyde. Specifically, the preparation method comprises the steps of directly coating cinnamyl aldehyde to a latex or silica gel catheter, or uniformly adding and dispersing a certain amount of cinnamyl aldehyde and other conventional ingredients to latex or silica gel in a raw material prevulcanization step of the conventional latex or silica gel catheter, then dipping by a conventional forming process to obtain the latex or silica gel catheter containing natural cinnamyl aldehyde, and finally, forming and drying to obtain a product. The catheter prepared by the method has the advantages of antibacterial and inflammation preventing effect and lubrication, so that not only are infection of various bacteria and complications are prevented, but also the frictional force is small, therefore, pain of patients can be effectively alleviated.
Description
Technical field
The present invention relates to a kind of catheter and preparation method thereof, particularly a kind of natural meat cinnamic aldehyde anti-inflammation lubricant catheter and preparation method thereof that contains belongs to the medical material preparing technical field.
Background technology
Medically, through per urethram inserting catheter, drain urine to bladder.Urethral catheterization is divided into two kinds of catheter retaining urethral catheterization and intermittent urethral catheterization.The former catheter is retained in the patient body always, just pulls out or regularly replace new pipe when the state of an illness is permitted.The latter then every urethral catheterization in 4-6 hour once is about to catheter and extracts after the bladder emptying.Its defective is: catheter needs to smear lubricant at front end before inserting patient body, and traditional softening agent causes difficult intubation easily, and patient's mucous membrane of urethra is broken, and causes ecchymosis, even causes the urine mineralization.In addition, urinary tract infection is common hospital infection, is only second to respiratory tract infection, accounts for 30.0% ~ 40.0% of hospital infection.And in the case of these urinary tract infection, have 75.0% ~ 80.0%, caused by indwelling catheter, be referred to as catheter dependency urinary tract infection (Catheter-associated urinary tract infection, CAUTI).CAUTI is difficult for causing people's attention as a kind of benign disease, but it has increased patient's misery virtually, has prolonged the hospital stays, has increased the weight of the financial burden of family and society, even can cause bacteremia, septicemia, pyuria disease, increases case fatality rate.
Antibacterials are the effective ways of preventing and treating CAUTI in a short time of generally acknowledging both at home and abroad, mainly are divided into general application and locality and use two kinds.But these antimicrobial drugs have drug resistance, for its healing has brought trouble.People begin to consider to use the catheter of different materials to lower bacterial infection.At present, catheter commonly used both at home and abroad has the silicone catheter of native rubber catheters, latex catheter, silicone catheter and lining silver etc., and wherein native rubber catheters is eliminated substantially because of its toxicity is very big.The price of latex catheter is the most cheap, but because stimulation and anaphylaxis can be arranged, is not suitable for putting for a long time staying so conform to.Less being not easy of the zest of silicone catheter stopped up, and relatively is applicable to secular indwelling catheter person.The silicone catheter of lining silver can make the memebrane protein precipitation that is attached on its lip-deep antibacterial, thereby stops microorganism to be grown; In addition, the silver ion of high concentration also has the effect of bacteria growing inhibiting.Therefore, it is more suitable for the patient in long-term indwelling catheter.
But there is bigger difference in the silicone catheter cost that covers silver than higher in the medical research personnel.At this phenomenon, the present invention adopts cinnamic aldehyde as the anti-inflammation material, and is with low cost, better effects if.Cortex Cinnamomi (cinnamon) is dry branch skin or the dried bark of canella Cortex Cinnamomi (Cinnamonum cassia Pre1.), has another name called Cortex cinnamomi japonici (Ramulus Cinnamomi), Da Gui, male osmanthus, purple osmanthus, beautiful osmanthus etc.It is a flavorant, is again rare Chinese medicine.Cortex Cinnamomi contains volatile oil (claiming Oleum Cinnamomi or Oleum Cinnamomi), except that antimicrobial main component cinnamic aldehyde (cinnamaldehyde), also contains a small amount of cinnamic acid, acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, phenylpropyl acetate, cinnamyl alcohol and coumarin etc.Zhang Wenjuan studies 8 kinds of fungal infection such as its cinnamic aldehyde aspergillus flavus resistings, show that this aldehyde not only has the effect of funguses such as obvious aspergillus flavus resisting, and after the effect of finite concentration cinnamic aldehyde, observe cell ultrastructure generation significant change (disappear, cell wall, endochylema etc. all solidify, degeneration etc.) as organelle.At present Researches on Cinnamomum cassia Presl is mainly concentrated on the medical science pharmacology, Japan medical science the expert discover, cinnamic aldehyde has significant curative effect to fungus, studies show that by 22 kinds of condition pathogenic funguses are carried out STUDY ON ANTIFUNGAL EFFECT OF CINNAMYL ALDEHYDE: cinnamic aldehyde is the antifungal active substance, mainly be by destroying fungal cell wall, medicine is infiltrated in the fungal cell, destroy organelle and play bactericidal action.
The present invention improves its dissolubility earlier with cinnamic aldehyde emulsifying, strengthens drug effect and bioavailability, has improved sulfuration efficient; Join and to play anti-inflammation and lubricated effect in the catheter; And China's Cortex Cinnamomi aboundresources output accounts for more than 80% of world's Cortex Cinnamomi output, and Guangdong, Guangxi two province's Cortex Cinnamomi output account for more than 95% of China's Cortex Cinnamomi output, for the exploitation and the rational and effective utilization of resource provides approach.Technology of the present invention is simple, and uses cinnamic aldehyde more with low cost than using the catheter that covers silver as the anti-inflammation material of catheter, is fit to suitability for industrialized production.
Summary of the invention
The purpose of this invention is to provide a kind of natural meat cinnamic aldehyde catheter and preparation method thereof that contains, this catheter has the effect of anti-inflammation, the infection of prevention various bacteria and the generation of complication; And have lubricating function, alleviate patient's misery.
In order to address the above problem, the technical solution adopted in the present invention is:
A kind of natural meat cinnamic aldehyde anti-inflammation lubricating type catheter and preparation method thereof that contains comprises:
(1) on latex or silicone catheter finished product, directly applies cinnamic aldehyde;
(2) in producing latex or the employed raw material of silicone catheter, add cinnamic aldehyde;
The cinnamic aldehyde that adds in raw material described in above-mentioned (2) is meant in the raw material presulfurization operation of conventional latex or silicone catheter, with a certain amount of cinnamic aldehyde together with other routines uniform mixing of preparing burden, adding also is distributed in latex or the silica gel, moulding process floods latex or the silicone catheter that becomes to contain the natural meat cinnamic aldehyde routinely again, obtains finished product by molding, drying process then;
The mass ratio of wherein said cinnamic aldehyde and latex/silica gel is preferably 0.5 ~ 1.5:100; Preferred mass ratio is 0.8:100 or 1.2:100;
For better implement the present invention, described cinnamic aldehyde need be prepared into the emulsified meat cinnamic aldehyde earlier, concrete grammar is: add 0.5g polyvinyl alcohol (PVA-1788) and 0.1g sodium alginate in the three-necked bottle of 250mL, the 100mL distilled water, heating for dissolving is 2 hours under stirring, be chilled to room temperature, add 3g Polyethylene Glycol-200 and be dissolved in the 10ml aqueous solution, after the constant temperature stirring and emulsifying 10 minutes, ice bath drips 1.28g isophorone diisocyanate (IPDI) down, 10.0g the mixture of cinnamic aldehyde and 3g acetone, the control mixing speed is about 1500rpm, dripping complete back continues to stir 30 minutes under ice bath, ultrasonic refinement 15 minutes, obtain faint yellow emulsion product, promptly get the emulsified meat cinnamic aldehyde, can arbitrary proportion miscible.
The vulcanizing agent that the mixture of described latex/silica gel and cinnamic aldehyde and presulfurization are adopted, the deal of activating agent are counted with mass parts:
100 parts in the mixture of latex/silica gel and cinnamic aldehyde
3 ~ 7 parts of vulcanizing agents
5 ~ 10 parts of activating agents;
Wherein, the mixture of described latex/silica gel and cinnamic aldehyde and the vulcanizing agent that presulfurization is adopted, the deal of activating agent are counted with mass parts:
100 parts in the mixture of latex/silica gel and cinnamic aldehyde
5 parts of vulcanizing agents
8 parts of activating agents;
In another preferred embodiment, be that 50 ~ 80 ℃ of ultrasonic agitation are handled in temperature during mixing, the time is 20 ~ 50 minutes.In another preferred embodiment, temperature is 40 ~ 70 ℃ during sulfuration, and the time is 1 ~ 2 hour.
The invention has the beneficial effects as follows:
(1) the present invention is by adding cinnamic aldehyde in latex or silica gel breast catheter or its raw material presulfurization operation, make in the catheter after cinnamic aldehyde is distributed in molding equably, during use, cinnamic aldehyde in the catheter can constantly be separated, play the function of anti-inflammation, in patient's urethra, the bladder with it microorganisms such as the antibacterial, fungus, mycete, spore of contact have killing action; And can improve the microcirculation of wound surrounding tissue, activate effectively and promote histiocytic growth, the healing of accelerated in wounds;
(2) cinnamic aldehyde adds in the catheter, the elasticity that catheter had, tensile strength and inherent character such as easy to use can better keep, and it has lubricant effect, and the stimulation to urethra during use reduces, not only alleviate patient's misery, and make treatment, nursing reach better effect;
(3) this technology is simple, and is with low cost, is fit to suitability for industrialized production.
The specific embodiment:
Below by embodiment the present invention is described in further details, these embodiment only are used for illustrating the present invention, do not limit the scope of the invention.
Preparation emulsified meat cinnamic aldehyde, concrete grammar is: add 0.5g polyvinyl alcohol (PVA-1788) and 0.1g sodium alginate in the three-necked bottle of 250mL, the 100mL distilled water, heating for dissolving is 2 hours under stirring, be chilled to room temperature, add 3g Polyethylene Glycol-200 and be dissolved in the 10ml aqueous solution, after the constant temperature stirring and emulsifying 10 minutes, ice bath drips 1.28g isophorone diisocyanate (IPDI) down, 10.0g the mixture of cinnamic aldehyde and 3g acetone, the control mixing speed is dripped complete back and is continued to stir 30 minutes under ice bath about 1500rpm, ultrasonic refinement 15 minutes obtains faint yellow emulsion product, promptly get the emulsified meat cinnamic aldehyde, can arbitrary proportion miscible.
Embodiment 1
(1) is equipped with 100 parts of latexes, 0.8 part of emulsified meat cinnamic aldehyde, 5 parts of vulcanizing agents, 8 parts of activating agents;
(2) with latex and cinnamic aldehyde mix homogeneously, add vulcanizing agent and activating agent again;
(3) be that 80 ℃ of ultrasonic agitation are handled in temperature, the time is 20 minutes;
(4) back is 70 ℃ of sulfurations 1 hour in temperature;
(5) can obtain finished product by molding, drying process then.
Embodiment 2
(1) is equipped with 100 parts of rubber, 1.2 parts of emulsified meat cinnamic aldehydes, 4 parts of vulcanizing agents, 10 parts of activating agents;
(2) with silica gel and cinnamic aldehyde mix homogeneously, add vulcanizing agent and activating agent again;
(3) be that 70 ℃ of ultrasonic agitation are handled in temperature, the time is 25 minutes;
(4) back is 60 ℃ of sulfurations 1.5 hours in temperature;
(5) can obtain finished product by molding, drying process then.
Embodiment 3
(1) is equipped with 100 parts of latexes, 0.5 part of emulsified meat cinnamic aldehyde, 3 parts of vulcanizing agents, 5 parts of activating agents;
(2) with rubber and cinnamic aldehyde mix homogeneously, add vulcanizing agent and activating agent again;
(3) be that 60 ℃ of ultrasonic agitation are handled in temperature, the time is 30 minutes;
(4) back is 50 ℃ of sulfurations 2 hours in temperature;
(5) can obtain finished product by molding, drying process then.
Embodiment 4
(1) is equipped with 100 parts of rubber, 0.9 part of emulsified meat cinnamic aldehyde, 6 parts of vulcanizing agents, 9 parts of activating agents;
(2) with rubber and cinnamic aldehyde mix homogeneously, add vulcanizing agent and activating agent again;
(3) be that 50 ℃ of ultrasonic agitation are handled in temperature, the time is 50 minutes;
(4) back is 40 ℃ of sulfurations 2 hours in temperature;
(5) can obtain finished product by molding, drying process then.
Embodiment 5
(1) is equipped with 100 parts of rubber, 1.5 parts of emulsified meat cinnamic aldehydes, 7 parts of vulcanizing agents, 7 parts of activating agents;
(2) with rubber and cinnamic aldehyde mix homogeneously, add vulcanizing agent and activating agent again;
(3) be that 65 ℃ of ultrasonic agitation are handled in temperature, the time is 20 minutes;
(4) back is 50 ℃ of sulfurations 1.5 hours in temperature;
(5) can obtain finished product by molding, drying process then.
Claims (9)
1. one kind contains natural meat cinnamic aldehyde anti-inflammation lubricating type catheter, it is characterized in that: this catheter is directly to apply cinnamic aldehyde on latex or the silicone catheter finished product or add cinnamic aldehyde in production latex or the employed raw material of silicone catheter.
2. one kind is used to prepare the described a kind of method that contains natural meat cinnamic aldehyde anti-inflammation lubricating type catheter of claim 1, it is characterized in that: its preparation method is to be covered with in cinnamic aldehyde or the raw material presulfurization operation at conventional latex or silicone catheter directly being coated with on latex for preparing or the silicone catheter finished product, a certain amount of cinnamic aldehyde is mixed equably together with other conventional batching, adding also is distributed in latex or the silica gel, moulding process floods latex or the silicone catheter that becomes to contain the natural meat cinnamic aldehyde routinely again, then by molding, drying process obtains finished product.
3. a kind of natural meat cinnamic aldehyde anti-inflammation lubricating type catheter that contains according to claim 1, it is characterized in that: the mass ratio of described cinnamic aldehyde and latex/silica gel is 0.5 ~ 1.5:100.
4. a kind of natural meat cinnamic aldehyde anti-inflammation lubricating type catheter that contains according to claim 1, it is characterized in that: the mass ratio of described cinnamic aldehyde and latex/silica gel is 0.8:100 or 1.2:100.
5. a kind of natural meat cinnamic aldehyde anti-inflammation lubricating type catheter that contains according to claim 1, it is characterized in that: described cinnamic aldehyde is the emulsified meat cinnamic aldehyde, the preparation method of emulsified meat cinnamic aldehyde is: add 0.5g PVAC polyvinylalcohol-1788 and 0.1g sodium alginate in the three-necked bottle of 250mL, the 100mL distilled water, heating for dissolving is 2 hours under stirring, be chilled to room temperature, add 3g Polyethylene Glycol-200 and be dissolved in the 10ml aqueous solution, after the constant temperature stirring and emulsifying 10 minutes, ice bath drips 1.28g isophorone diisocyanate IPDI down, 10.0g the mixture of cinnamic aldehyde and 3g acetone, the control mixing speed is at 1500rpm, dripping complete back continues to stir 30 minutes under ice bath, ultrasonic refinement 15 minutes, obtain faint yellow emulsion product, be the emulsified meat cinnamic aldehyde.
6. a kind of preparation method that contains natural meat cinnamic aldehyde anti-inflammation lubricating type catheter according to claim 2 is characterized in that: the used vulcanizing agent of the mixture of described latex/silica gel and cinnamic aldehyde and presulfurization, the deal of activating agent are counted with mass parts:
100 parts in the mixture of latex/silica gel and cinnamic aldehyde
3 ~ 7 parts of vulcanizing agents
5 ~ 10 parts of activating agents.
7. a kind of preparation method that contains natural meat cinnamic aldehyde anti-inflammation lubricating type catheter according to claim 2 is characterized in that: the used vulcanizing agent of the mixture of described latex/silica gel and cinnamic aldehyde and presulfurization, the deal of activating agent are counted with mass parts:
100 parts in the mixture of rubber/silica gel and cinnamic aldehyde
5 parts of vulcanizing agents
8 parts of activating agents.
8. a kind of preparation method that contains natural meat cinnamic aldehyde anti-inflammation lubricating type catheter according to claim 2 is characterized in that: be to be that ultrasonic agitation is handled under 50 ~ 80 ℃ of conditions in temperature during mixing, the time is 20 ~ 50 minutes.
9. a kind of preparation method that contains natural meat cinnamic aldehyde anti-inflammation lubricating type catheter according to claim 2, it is characterized in that: temperature is 40 ~ 70 ℃ during presulfurization, the time is 1 ~ 2 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310160713.XA CN103212112B (en) | 2013-05-06 | 2013-05-06 | A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310160713.XA CN103212112B (en) | 2013-05-06 | 2013-05-06 | A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103212112A true CN103212112A (en) | 2013-07-24 |
| CN103212112B CN103212112B (en) | 2015-10-07 |
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| CN201310160713.XA Expired - Fee Related CN103212112B (en) | 2013-05-06 | 2013-05-06 | A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107185052A (en) * | 2017-05-31 | 2017-09-22 | 苏州蔻美新材料有限公司 | A kind of inhibiting bacteria and diminishing inflammation lubricates the preparation method of catheter |
| CN113491685A (en) * | 2021-09-09 | 2021-10-12 | 广东工业大学 | Composition for inhibiting macrophage activation and application thereof in preparation of anti-inflammatory product |
| CN115645629A (en) * | 2022-09-08 | 2023-01-31 | 沈阳贺麒医疗科技合伙企业(有限合伙) | Drug-loaded silica gel catheter and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107185052A (en) * | 2017-05-31 | 2017-09-22 | 苏州蔻美新材料有限公司 | A kind of inhibiting bacteria and diminishing inflammation lubricates the preparation method of catheter |
| CN113491685A (en) * | 2021-09-09 | 2021-10-12 | 广东工业大学 | Composition for inhibiting macrophage activation and application thereof in preparation of anti-inflammatory product |
| CN115645629A (en) * | 2022-09-08 | 2023-01-31 | 沈阳贺麒医疗科技合伙企业(有限合伙) | Drug-loaded silica gel catheter and preparation method thereof |
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| CN103212112B (en) | 2015-10-07 |
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