CN103212112B - A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof - Google Patents
A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof Download PDFInfo
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- CN103212112B CN103212112B CN201310160713.XA CN201310160713A CN103212112B CN 103212112 B CN103212112 B CN 103212112B CN 201310160713 A CN201310160713 A CN 201310160713A CN 103212112 B CN103212112 B CN 103212112B
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- latex
- cinnamic aldehyde
- aldehyde
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- inflammation
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- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 title claims abstract description 74
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 230000001050 lubricating effect Effects 0.000 title claims abstract description 13
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims abstract description 56
- 229940117916 cinnamic aldehyde Drugs 0.000 claims abstract description 56
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims abstract description 55
- 239000004816 latex Substances 0.000 claims abstract description 31
- 229920000126 latex Polymers 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 16
- 239000000741 silica gel Substances 0.000 claims abstract description 16
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 238000000465 moulding Methods 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000006424 Flood reaction Methods 0.000 claims abstract description 3
- 238000009472 formulation Methods 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 230000003213 activating effect Effects 0.000 claims description 18
- 235000013372 meat Nutrition 0.000 claims description 12
- 229920001971 elastomer Polymers 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000013019 agitation Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 239000005058 Isophorone diisocyanate Substances 0.000 claims 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 238000005461 lubrication Methods 0.000 abstract description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- 238000005987 sulfurization reaction Methods 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 208000019206 urinary tract infection Diseases 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 235000019082 Osmanthus Nutrition 0.000 description 3
- 241000333181 Osmanthus Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000003708 urethra Anatomy 0.000 description 3
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 description 2
- 241000228197 Aspergillus flavus Species 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- JRJGKUTZNBZHNK-UHFFFAOYSA-N 3-phenylpropyl acetate Chemical compound CC(=O)OCCCC1=CC=CC=C1 JRJGKUTZNBZHNK-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000008718 Pyuria Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 208000013223 septicemia Diseases 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of preparation method containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter, specifically on latex or silicone catheter finished product, directly can apply cinnamic aldehyde, also can in the raw material pre-sulphiding procedure of conventional latex or silicon catheter, a certain amount of cinnamic aldehyde is added equably together with other conventional formulations and is distributed in latex or silica gel, moulding process floods into latex containing Natural cinnamyl aldehyde or silicone catheter routinely again, then obtains finished product by molding, drying process.Catheter prepared by the method has effect of anti-inflammation and the advantage of lubrication, not only can prevent the infection of various bacteria and the generation of complication, and frictional force is little, effectively can alleviate the misery of patient.
Description
Technical field
The present invention relates to a kind of catheter and preparation method thereof, particularly one contains Natural cinnamyl aldehyde anti-inflammation lubricant catheter and preparation method thereof, belongs to medical material preparing technical field.
Background technology
Medically, through per urethram inserting catheter to bladder, urine is drained.Urethral catheterization is divided into catheter retaining urethral catheterization and intermittent urethral catheterization two kinds.The former is retained in patient body by catheter always, just pulls out or regularly replace new pipe when the state of an illness is permitted.Latter every urethral catheterization in 4-6 hour once, is extracted by catheter after bladder empties.Its defect is: catheter is before insertion patient body, and need smear lubricant in front end, traditional softening agent easily causes difficult intubation, the mucous membrane of urethra of patient is broken, causes ecchymosis, even cause urine mineralization.In addition, urinary tract infection is common hospital infection, is only second to respiratory tract infection, accounts for 30.0% ~ 40.0% of hospital infection.And in the case of these urinary tract infection, have 75.0% ~ 80.0% to be caused by indwelling catheter, be referred to as catheter dependency urinary tract infection (Catheter-associated urinary tract infection, CAUTI).CAUTI, as a kind of benign disease, not easily causes the attention of people, but it adds the misery of patient virtually, extends the hospital stays, has increased the weight of the financial burden of family and society, even can cause bacteremia, septicemia, pyuria disease, increases case fatality rate.
Antibacterials are the effective ways preventing and treating CAUTI in a short time of generally acknowledging both at home and abroad, are mainly divided into general application and locality to apply two kinds.But these antimicrobial drugs have drug resistance, for its healing brings trouble.People start to consider to use the catheter of different materials to lower bacteriological infection.At present, catheter conventional both at home and abroad has the silicone catheter etc. of native rubber catheters, latex catheter, silicone catheter and coating silver, and wherein native rubber catheters is eliminated very greatly substantially because of its toxicity.The price of latex catheter is the most cheap, but owing to can have stimulation and anaphylaxis, therefore does not conform to and be suitable for putting for a long time staying.The zest of silicone catheter is less is not easy blocking, compares and is applicable to long-term indwelling catheter person.The silicone catheter of coating silver can make the memebrane protein of the antibacterial be attached on its surface precipitate, thus stops microbial growth; In addition, the silver ion of high concentration also has effect of bacteria growing inhibiting.Therefore, it is more suitable for the patient of Preserving time catheter.
But the silicone catheter cost compare covering silver is high, there is larger difference in medical researchers.For this phenomenon, the present invention adopts cinnamic aldehyde as anti-inflammation material, with low cost, better effects if.The dry branch skin that Cortex Cinnamomi (cinnamon) is canella Cortex Cinnamomi (Cinnamonum cassia Pre1.) or dried bark, have another name called Cortex cinnamomi japonici (Ramulus Cinnamomi), great Gui, male osmanthus, purple osmanthus, beautiful osmanthus etc.It is flavorant, is again rare Chinese medicine.Cortex Cinnamomi, containing volatile oil (claiming Oleum Cinnamomi or Oleum Cinnamomi), except antibacterial main component cinnamic aldehyde (cinnamaldehyde), also contains a small amount of cinnamic acid, acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, phenylpropyl acetate, cinnamyl alcohol and coumarin etc.Zhang Wenjuan is studied 8 kinds of fungal infection such as its cinnamic aldehyde aspergillus flavus resistings, show that this aldehyde not only has the effect of the funguses such as obvious aspergillus flavus resisting, and after the effect of finite concentration cinnamic aldehyde, observe cell ultrastructure generation significant change (as organelle disappears, cell wall, endochylema etc. all solidify, degeneration etc.).At present medical science is mainly concentrated on pharmacologically to the research of Cortex Cinnamomi, Japan medical science expert studies discovery, cinnamic aldehyde has significant curative effect to fungus, show by carrying out STUDY ON ANTIFUNGAL EFFECT OF CINNAMYL ALDEHYDE research to 22 kinds of opportunistic fungus: cinnamic aldehyde is antifungal active substance, mainly by destroying fungal cell wall, make medicine infiltrate in fungal cell, destroy organelle and play bactericidal action.
The present invention, first by cinnamic aldehyde emulsifying, improves its dissolubility, strengthens drug effect and bioavailability, improves curing efficiency; Join the effect can playing anti-inflammation and lubrication in catheter; And China's Cortex Cinnamomi aboundresources output accounts for more than 80% of world's Cortex Cinnamomi output, and Guangdong, Guangxi two province Cortex Cinnamomi output account for more than 95% of China's Cortex Cinnamomi output, for resource exploitation and rationally effective utilization provide approach.Present invention process is simple, and uses cinnamic aldehyde more with low cost than using the catheter covering silver as the anti-inflammation material of catheter, is applicable to suitability for industrialized production.
Summary of the invention
The object of this invention is to provide one containing Natural cinnamyl aldehyde catheter and preparation method thereof, this catheter has effect of anti-inflammation, the prevention infection of various bacteria and the generation of complication; And there is lubricating function, alleviate the misery of patient.
In order to solve the problem, the technical solution adopted in the present invention is:
A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof, comprising:
(1) on latex or silicone catheter finished product, directly cinnamic aldehyde is applied;
(2) cinnamic aldehyde is added producing in the raw material that latex or silicone catheter use;
The cinnamic aldehyde that adds in the feed described in above-mentioned (2) refers in the raw material pre-sulphiding procedure of conventional latex or silicone catheter, by a certain amount of cinnamic aldehyde together with other conventional formulations Homogeneous phase mixing, add and be distributed in latex or silica gel, moulding process floods into latex containing Natural cinnamyl aldehyde or silicone catheter routinely again, then obtains finished product by molding, drying process;
The mass ratio of wherein said cinnamic aldehyde and latex/silica gel is preferably 0.5 ~ 1.5:100; Preferred mass ratio is 0.8:100 or 1.2:100;
In order to better implement the present invention, described cinnamic aldehyde need first be prepared into emulsified meat cinnamic aldehyde, concrete grammar is: in the three-necked bottle of 250mL, add 0.5g polyvinyl alcohol (PVA-1788) and 0.1g sodium alginate, 100mL distilled water, stir lower heating for dissolving 2 hours, be chilled to room temperature, add 3g Polyethylene Glycol-200 and be dissolved in 10ml aqueous solution, constant temperature stirring and emulsifying is after 10 minutes, 1.28g isophorone diisocyanate (IPDI) is dripped under ice bath, the mixture of 10.0g cinnamic aldehyde and 3g acetone, control mixing speed at about 1500rpm, drip after finishing and continue to stir 30 minutes under ice bath, Fine by Ultrasonic 15 minutes, obtain faint yellow emulsion product, obtain emulsified meat cinnamic aldehyde, can arbitrary proportion miscible.
The vulcanizing agent that described latex/silica gel and the mixture of cinnamic aldehyde and presulfurization adopt, the deal of activating agent are counted with mass parts:
100 parts, the mixture of latex/silica gel and cinnamic aldehyde
Vulcanizing agent 3 ~ 7 parts
Activating agent 5 ~ 10 parts;
Wherein, the vulcanizing agent that can further preferably make the mixture of described latex/silica gel and cinnamic aldehyde and presulfurization adopt, the deal of activating agent are counted with mass parts:
100 parts, the mixture of latex/silica gel and cinnamic aldehyde
Vulcanizing agent 5 parts
Activating agent 8 parts;
In another preferred embodiment, be 50 ~ 80 DEG C of ultrasonic agitation process in temperature during mixing, the time is 20 ~ 50 minutes.In another preferred embodiment, during sulfuration, temperature is 40 ~ 70 DEG C, and the time is 1 ~ 2 hour.
the invention has the beneficial effects as follows:
(1) the present invention by adding cinnamic aldehyde in latex or silica gel breast catheter or its raw material pre-sulphiding procedure, in catheter after making cinnamic aldehyde be distributed in molding equably, during use, cinnamic aldehyde in catheter can constantly be separated, play the function of anti-inflammation, to microorganisms such as the antibacterial contacted with it in patient's urethra, bladder, fungus, mycete, spores, there is killing action; And the microcirculation of periwound tissue can be improved, effectively activate and promote histiocytic growth, the healing of accelerated in wounds;
(2) cinnamic aldehyde adds in catheter, the elasticity that catheter has, tensile strength and the inherent character such as easy to use can better keep, and it has lubricant effect, reduces during use to the stimulation of urethra, not only alleviate the misery of patient, and make treatment, nursing reach better effect;
(3) this technique is simple, with low cost, is applicable to suitability for industrialized production.
detailed description of the invention:
Be described in further details the present invention below by embodiment, these embodiments are only used for the present invention is described, do not limit the scope of the invention.
Preparation emulsified meat cinnamic aldehyde, concrete grammar is: in the three-necked bottle of 250mL, add 0.5g polyvinyl alcohol (PVA-1788) and 0.1g sodium alginate, 100mL distilled water, stir lower heating for dissolving 2 hours, be chilled to room temperature, add 3g Polyethylene Glycol-200 and be dissolved in 10ml aqueous solution, constant temperature stirring and emulsifying is after 10 minutes, 1.28g isophorone diisocyanate (IPDI) is dripped under ice bath, the mixture of 10.0g cinnamic aldehyde and 3g acetone, control mixing speed at about 1500rpm, drip after finishing and continue to stir 30 minutes under ice bath, Fine by Ultrasonic 15 minutes, obtain faint yellow emulsion product, obtain emulsified meat cinnamic aldehyde, can arbitrary proportion miscible.
Embodiment 1
(1) standby latex 100 parts, emulsified meat cinnamic aldehyde 0.8 part, vulcanizing agent 5 parts, activating agent 8 parts;
(2) latex is mixed homogeneously with cinnamic aldehyde, then add vulcanizing agent and activating agent;
(3) be 80 DEG C of ultrasonic agitation process in temperature, the time is 20 minutes;
(4) be 70 DEG C of sulfurations 1 hour in temperature after;
(5) then finished product can be obtained by molding, drying process.
Embodiment 2
(1) standby rubber 100 parts, emulsified meat cinnamic aldehyde 1.2 parts, vulcanizing agent 4 parts, activating agent 10 parts;
(2) silica gel is mixed homogeneously with cinnamic aldehyde, then add vulcanizing agent and activating agent;
(3) be 70 DEG C of ultrasonic agitation process in temperature, the time is 25 minutes;
(4) be 60 DEG C of sulfurations 1.5 hours in temperature after;
(5) then finished product can be obtained by molding, drying process.
Embodiment 3
(1) standby latex 100 parts, emulsified meat cinnamic aldehyde 0.5 part, vulcanizing agent 3 parts, activating agent 5 parts;
(2) rubber is mixed homogeneously with cinnamic aldehyde, then add vulcanizing agent and activating agent;
(3) be 60 DEG C of ultrasonic agitation process in temperature, the time is 30 minutes;
(4) be 50 DEG C of sulfurations 2 hours in temperature after;
(5) then finished product can be obtained by molding, drying process.
Embodiment 4
(1) standby rubber 100 parts, emulsified meat cinnamic aldehyde 0.9 part, vulcanizing agent 6 parts, activating agent 9 parts;
(2) rubber is mixed homogeneously with cinnamic aldehyde, then add vulcanizing agent and activating agent;
(3) be 50 DEG C of ultrasonic agitation process in temperature, the time is 50 minutes;
(4) be 40 DEG C of sulfurations 2 hours in temperature after;
(5) then finished product can be obtained by molding, drying process.
Embodiment 5
(1) standby rubber 100 parts, emulsified meat cinnamic aldehyde 1.5 parts, vulcanizing agent 7 parts, activating agent 7 parts;
(2) rubber is mixed homogeneously with cinnamic aldehyde, then add vulcanizing agent and activating agent;
(3) be 65 DEG C of ultrasonic agitation process in temperature, the time is 20 minutes;
(4) be 50 DEG C of sulfurations 1.5 hours in temperature after;
(5) then finished product can be obtained by molding, drying process.
Claims (8)
1. containing a Natural cinnamyl aldehyde anti-inflammation lubricating type catheter, it is characterized in that: this catheter is direct coating cinnamic aldehyde or add cinnamic aldehyde producing in the raw material that latex or silicone catheter use on latex or silicone catheter finished product, described cinnamic aldehyde is emulsified meat cinnamic aldehyde, the preparation method of emulsified meat cinnamic aldehyde is: in the three-necked bottle of 250mL, add 0.5g PVAC polyvinylalcohol-1788 and 0.1g sodium alginate, 100mL distilled water, stir lower heating for dissolving 2 hours, be chilled to room temperature, add 3g Polyethylene Glycol-200 and be dissolved in 10ml aqueous solution, constant temperature stirring and emulsifying is after 10 minutes, 1.28g isophorone diisocyanate IPDI is dripped under ice bath, the mixture of 10.0g cinnamic aldehyde and 3g acetone, control mixing speed at 1500rpm, drip after finishing and continue to stir 30 minutes and Fine by Ultrasonic 15 minutes under ice bath, obtain faint yellow emulsion product, be emulsified meat cinnamic aldehyde.
2. one kind for the preparation of a kind of method containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter according to claim 1, it is characterized in that: its preparation method is directly coated with to be covered with cinnamic aldehyde or in the raw material pre-sulphiding procedure of conventional latex or silicone catheter on the latex prepared or silicone catheter finished product, a certain amount of cinnamic aldehyde is mixed equably together with other conventional formulations, add and be distributed in latex or silica gel, moulding process floods into latex containing Natural cinnamyl aldehyde or silicone catheter routinely again, then molding is passed through, drying process obtains finished product.
3. one according to claim 1 contains Natural cinnamyl aldehyde anti-inflammation lubricating type catheter, it is characterized in that: the mass ratio of described cinnamic aldehyde and latex/silica gel is 0.5 ~ 1.5:100.
4. one according to claim 1 contains Natural cinnamyl aldehyde anti-inflammation lubricating type catheter, it is characterized in that: the mass ratio of described cinnamic aldehyde and latex/silica gel is 0.8:100 or 1.2:100.
5. a kind of preparation method containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter according to claim 2, is characterized in that: the deal of described latex/silica gel and the mixture of cinnamic aldehyde and presulfurization vulcanizing agent used, activating agent is counted with mass parts:
100 parts, the mixture of latex/silica gel and cinnamic aldehyde
Vulcanizing agent 3 ~ 7 parts
Activating agent 5 ~ 10 parts.
6. a kind of preparation method containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter according to claim 2, is characterized in that: the deal of described latex/silica gel and the mixture of cinnamic aldehyde and presulfurization vulcanizing agent used, activating agent is counted with mass parts:
100 parts, the mixture of rubber/silica gel and cinnamic aldehyde
Vulcanizing agent 5 parts
Activating agent 8 parts.
7. a kind of preparation method containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter according to claim 2, is characterized in that: be ultrasonic agitation process under temperature is 50 ~ 80 DEG C of conditions during mixing, the time is 20 ~ 50 minutes.
8. a kind of preparation method containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter according to claim 2, it is characterized in that: during presulfurization, temperature is 40 ~ 70 DEG C, the time is 1 ~ 2 hour.
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| CN201310160713.XA CN103212112B (en) | 2013-05-06 | 2013-05-06 | A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof |
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| CN201310160713.XA CN103212112B (en) | 2013-05-06 | 2013-05-06 | A kind of containing Natural cinnamyl aldehyde anti-inflammation lubricating type catheter and preparation method thereof |
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| CN103212112B true CN103212112B (en) | 2015-10-07 |
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| CN107185052A (en) * | 2017-05-31 | 2017-09-22 | 苏州蔻美新材料有限公司 | A kind of inhibiting bacteria and diminishing inflammation lubricates the preparation method of catheter |
| CN113491685B (en) * | 2021-09-09 | 2021-12-10 | 广东工业大学 | Composition for inhibiting macrophage activation and application thereof in preparation of anti-inflammatory product |
| CN115645629A (en) * | 2022-09-08 | 2023-01-31 | 沈阳贺麒医疗科技合伙企业(有限合伙) | Drug-loaded silica gel catheter and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159738A (en) * | 1995-06-07 | 1997-09-17 | 普罗嘉德公司 | Disinfection of a contaminated environment |
| CN1597009A (en) * | 2003-09-17 | 2005-03-23 | 邵贤斌 | Nanometer antibacterial urinary catheter |
| CN101361991A (en) * | 2008-09-19 | 2009-02-11 | 华东医院 | Slowly released type antibiotic medical catheter and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221425B1 (en) * | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
| FR2946255B1 (en) * | 2009-06-05 | 2013-05-24 | Natepharm | COMPOSITION COMPRISING TRANS-CINNAMALDEHYDE |
-
2013
- 2013-05-06 CN CN201310160713.XA patent/CN103212112B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159738A (en) * | 1995-06-07 | 1997-09-17 | 普罗嘉德公司 | Disinfection of a contaminated environment |
| CN1597009A (en) * | 2003-09-17 | 2005-03-23 | 邵贤斌 | Nanometer antibacterial urinary catheter |
| CN101361991A (en) * | 2008-09-19 | 2009-02-11 | 华东医院 | Slowly released type antibiotic medical catheter and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 何映平.预硫化.《天然橡胶加工学》.海口市:海南出版社,2007,第152-155页. * |
| 肉桂醛条件致病性真菌作用的研究;张文娟;《临床皮肤科杂志》;19951231(第4期);第220页左栏第2段至右栏末段 * |
| 肉桂醛的研究与应用;孙罗美等;《广东饲料》;20121231;第21卷(第12期);全文 * |
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| CN103212112A (en) | 2013-07-24 |
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