CN202505597U - Negative pressure therapy wound paste containing metal ion germicide - Google Patents
Negative pressure therapy wound paste containing metal ion germicide Download PDFInfo
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- CN202505597U CN202505597U CN2011204934214U CN201120493421U CN202505597U CN 202505597 U CN202505597 U CN 202505597U CN 2011204934214 U CN2011204934214 U CN 2011204934214U CN 201120493421 U CN201120493421 U CN 201120493421U CN 202505597 U CN202505597 U CN 202505597U
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- negative pressure
- woven fabrics
- wound
- metal ion
- chitosan
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Abstract
The utility model relates to a wound paste. The wound paste contains metal ion germicide, is used for sealing a negative pressure therapy wound, and has antibiosis and tissue repair promoting functions. The wound paste comprises a sponge layer and a negative pressure suction tube inserted into the sponge layer, and further comprises a non-woven fabric combined with the sponge layer together. The negative pressure therapy wound paste containing the metal ion germicide guarantees effective implementation of negative pressure drainage, and provides a comprehensive treatment effect of the antibiosis and tissue healing promoting at the same time, so the treatment effect of diabetes mellitus ulceration wounds and other wounds which are chronic and refractory is improved.
Description
Technical field
This utility model belongs to field of medical products, relates to a kind of wound-surface plaster of treating wound surface, relates in particular to a kind of metal ion antibacterial and is used for having concurrently of closed negative pressure treatment wound surface wound-surface plaster antibiotic and promotion tissue repair function.
Background technology
(chitosan, CS) be is raw material with the chitin to chitosan, water-soluble poly-glucosamine that deacetylate obtains in concentrated base.It derives from natural material fully, draws materials conveniently, and is cheap.Aspect physicochemical property, chitosan has excellent biological compatibility, and is biodegradable to human non-toxic, but also has hemostasis, antibacterial activity and film property, thereby has been widely used in fields such as food, medicine, weaving, printing and dyeing, cosmetics and environmental protection.
The application of chitosan aspect medical science mainly contains: (1) promotes blood coagulation and wound healing.Chitosan has the effect that promotes blood coagulation, can be used as hemorrhage.It also can be used for the Wound filling material, has sterilization, promotes wound healing, absorbs Wound exudate, is difficult for effects such as syneresis.(2) as the sustained-release matrix of medicine.Chitosan can be generated natural metabolite by biological intravital lysozyme degraded, has characteristics nontoxic, that can be absorbed fully by organism, therefore has bigger superiority with it as medicinal slow release agent.(3) be used for artificial tissue and organ.The complex of chitosan and calcium phosphate can be used as the substitute of bone, is used for the repairing of bone and the filler of tooth; The composite of chitosan derivatives and polyester can be used as artificial blood vessel.Abewidra once released a kind of new material of repairing burn, ulcer and skin infection---" artificial skin "; This repair materials has the function of natural skin; Not only can make wound avoid the infection of antibacterial, but also can penetration air and moisture, wound healing promoted.(4) has immunoregulatory activity.Chitosan ability activating complement system mediates its biological effect, improves cytophagous function.Exist the receptor of bacterial polysaccharides on the macrophage surface; And chitosan is as the analog of bacterial polysaccharides; Can stimulate macrophage activation, promote its phagocytic function, strengthen its cooperative effect in other immunne response; Thereby realize the adjusting of body, mediated cell immunne response and HI to T cell, NK cell and B cell.(5) other medical usage: chitosan gel rubber can be used as the carrier of tooth antibiotics, has hemostasis, antiinflammatory and conglutinant function; Can reduce the cholesterol concentration in serum and the liver, be used for cholesterol-lowering agent; Chitosan can be strengthened the liver function, prevents because the liver that causes of excessive consumption of alcohol is still drank after a night, and has absorption and excretory effect to remaining in intravital heavy metal, toxin, pesticide, chemical pigment; Chitosan can be regulated intravital pH value to alkalescence, improves the utilization rate of insulin, helps preventing and treating diabetes; In addition, it also has the function of endocrine regulation system, impels insulin secretion normal, suppresses blood sugar increasing, blood fat reducing.
As a kind of natural antibacterial agent, chitosan has better antibacterial activity, can suppress the growth and breeding of part antibacterial, fungus and virus.Mechanism comprises: one, the polycation of chitosan is prone to and the electronegative group effect in fungal cell surface, thereby changes pathogen flowability of cell membranes and permeability; Two, disturb duplicating and transcribing of pathogenic microorganism DNA; Three, blocking-up pathogen metabolism.But its antibacterial efficacy is limited, and it is not satisfactory to continue antibacterial effect, thereby has limited its application in anti-biotic material.
Various types of chronic wound treatments are thorny, are still one of clinical difficult problem that needs to be resolved hurrily at present.With the diabetic ulcer is example: along with the arrival of aging society, the sickness rate of diabetic ulcer increases year by year.Ulcer protracted course of disease, and easy concurrent infection involve deep tissue, can cause that far-end of limb is downright bad, and it is all higher with fatality rate to disable.Known oxidation stress damage is one of crucial paathogenic factor of diabetic ulcer.In tissue, accumulate the response to oxidative stress that is caused by hyperglycemia and terminal glycosylation dead end product (AGEs), but coup injury vascular endothelial cell and function thereof cause microcirculation disturbance, make the organization healing ability drop.
Metallothionein (Metal-lothionein MT) is one type of metal-binding protein that extensively is present in low-molecular-weight in the biological cell, is rich in cysteine, the sulfydryl in its molecule very easily with some electrophilicity material effect, particularly can with combined with radical.Recent study finds that MT is potential antioxidant, has the effect of removing interior free yl, anti-oxidation stress, and damage has protective effect to the diabetes tissue.Type 2 diabetes mellitus patient skeletal muscle and MT in serum level all reduce, and kinetic oxidative stress is lacked reaction, and vivo oxidation system of defense hypofunction is described.
(Vacuum-Assisted Closure is an advanced person's a Wound treating technology VAC) to closed negative pressure drainage,, is popularized rapidly in American-European countries subsequently in initiative in 1992 by German doctor Fleischmann.In recent years, increasing domestic hospital has introduced this technology, as the prefered method of the multiple acute and chronic wound surface of treatment.The deficiency that exists at present mainly is: employed negative pressure treatment dressing only contains medical sponge and drainage tube, lacks good wound surface cladding material, thereby on treatment mechanism, can only utilize the mechanical suction effect of negative pressure, acts on comparatively single; Limited to some with complicacy, the refractory wound surface effect of infection and self healing ability difference.
The utility model content
In order to solve the above-mentioned technical problem that exists in the background technology; This utility model provides a kind of negative pressure drainage that both guaranteed effectively to implement; Produce antibiotic and the Comprehensive Treatment effect that promotes organization healing simultaneously, thereby improve the negative pressure treatment wound-surface plaster of metal ion antibacterial of the therapeutic effect of, refractory wound surface chronic for diabetic ulcer etc.
The technical solution of this utility model is: this utility model provides a kind of negative pressure treatment wound-surface plaster of metal ion antibacterial; The vacuum suction pipe that comprises spongy layer and stretch into spongy layer, its special character is: the wound-surface plaster that said containing metal antibacterial is used to treat wound surface also comprises the non-woven fabrics of combining with spongy layer.
Above-mentioned non-woven fabrics is the chitosan non-woven fabrics.
Above-mentioned non-woven fabrics is a hydrophobicity chitosan non-woven fabrics.
Above-mentioned non-woven fabrics is the chitosan non-woven fabrics of hydrophobicity metal ion antibacterial.
Above-mentioned metal ion antibacterial agent is to contain zinc ion antibacterial, copper ions antibacterial or contain the silver-ion antibiotic agent.
Above-mentioned non-woven fabrics is one or more layers; Preferred 5～15 layers.
Above-mentioned spongy layer is a hydrophilic polyurethane sponge.
The utility model has the advantages that:
This utility model adopts the method for the laggard row metal ionic adsorption of propylene polymerization to prepare the chitosan non-woven fabrics of hydrophobicity metal ion antibacterial; And, form novel block negative pressure treatment wound-surface plaster with itself and hydrophilic polyurethane sponge and vacuum suction pipe Combined application.This wound-surface plaster is applicable to chronic, refractory wound surface such as treatment diabetic ulcer.Use this novel wound-surface plaster, can overcome existing negative pressure treatment dressing and not contain wound surface cladding material, the single deficiency of therapeutical effect.Can effectively implement on the basis of negative pressure drainage, bring into play antibiotic with alleviate the damage of histiocyte oxidative stress, promote the Comprehensive Treatment effect of organization healing, thereby raising is to the therapeutic effect of refractory wound surface.Specific as follows:
(1) novel wound-surface plaster has wound surface drain, antibiotic and promote the Comprehensive Treatment effect of organization healing concurrently; (2) the associating antimicrobial effect of wound-surface plaster performance chitosan and metal ion, it is low that has a broad antifungal spectrum, antibacterial efficacy strengthen, are difficult for generation drug resistance, persistent and toxicity; (3) wound-surface plaster continues to discharge Zn
2+Deng metal ion, but induced tissue cellular expression metallothionein alleviates the cellular oxidation stress damage, promotes wound repair; (4) the membranous type wound-surface plaster has certain intensity and pliability, can avoid directly the grow into micropore of sponge material of wound surface adhesion and new granulation tissue; (5) material good biocompatibility, to human non-toxic, harmless, environmentally friendly.
Description of drawings
Fig. 1 is the structural representation of the wound-surface plaster that provides of this utility model;
Wherein:
1-vacuum suction pipe; The 2-spongy layer; The 3-nonwoven layer.
The specific embodiment
The theoretical basis of this utility model is: the chitosan material good biocompatibility, to human non-toxic property, be applied to wound surface have antibiotic, preserve moisture and multiple function such as hemostasis.And metal ions such as zinc, copper, silver belong to the inorganic metal antibacterial, and has a broad antifungal spectrum all has good antibacterial performance to escherichia coli, bacillus pyocyaneus and staphylococcus aureus etc.; Safe, toxicity is little, to skin mucosa nonirritant, teratogenesis, not carcinogenic not; Drug resistance is little, and its unique sterilization mechanism makes antibacterial be difficult for producing drug resistance.Metal ion antibacterial agent with after the chitosan non-woven fabrics combines, is realized the associating of antibacterial mechanisms and the lasting release of metal ion, can keep the effective antibiotic concentration of wound surface, strengthened the antibacterial activity of wound-surface plaster.
In addition, zinc, copper are the trace element of needed by human, also are under the physiological condition and the bonded major metal element of metallothionein (MT), can the induced tissue organ in the genetic transcription of MT-I and MT-II, thereby increase the expression of MT.Contain the chitosan of zinc ion or copper ion can be on wound surface slowly, lasting zinc ion releasing or copper ion, thereby induced tissue cell MT expresses and increases, the effect of free radical, antioxidant stress injury is removed in performance, the protective tissue cell promotes wound repair.
Referring to Fig. 1; This utility model provides a kind of metal ion antibacterial to be used for the wound-surface plaster of closed negative pressure treatment wound surface; This wound-surface plaster is combined to form by the chitosan non-woven fabrics of hydrophobicity metal ion antibacterial 3 and hydrophilic polyurethane sponge 2 and the vacuum suction pipe 1 that stretches into spongy layer; Become realize eventually transudate absorb, antibiotic and promote the negative pressure treatment wound-surface plaster of tissue repair, the metal antibacterial agent can be zinc ion, copper ion or silver ion.
If contain the chitosan of metal ion antibacterial agent is the chitosan that contains zinc ion; Provide technical scheme to specify as follows to this utility model: hydrophobicity contains cadmia polysaccharide non-woven fabrics, and adopting the chitosan non-woven fabrics of intermediate molecular weight (30000～60000), deacetylation 50%～70% is raw material; Employing water is reaction medium, and 5% sodium peroxydisulfate is a reaction initiator, and 8% ferrous sulfate is a polymerization inhibitor, carries out glycerol polymerization behind the adding acrylic acid down at 40 ℃, and controlling reaction time made aggregate rate between 100%～300% between 1～1.5 hour; After polymerization, polymerizate is placed on the absorption of carrying out zinc in 1.5% solution of zinc sulfate through the water depth washing, make the zinc adsorbance reach 50～150mg/g.
Hydrophobicity contains cadmia polysaccharide non-woven fabrics and constitutes by 5～15 layers, and its thickness is about about 3～10mm.In use, owing to have ion exchange process between the contained zinc ion of sodium ion, potassium ion and dressing in blood and the wound exudate, the zinc burst size remains on 0.8～1.7 μ mol/cm in the time of can guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 12～18mm, and porosity is 50%～80%.
Embodiment 1:
Hydrophobicity contains cadmia polysaccharide non-woven fabrics, and adopting the chitosan non-woven fabrics of intermediate molecular weight (60000), deacetylation 50% is raw material, carries out the absorption of zinc ion behind the employing propylene polymerization (aggregate rate 300%), makes the zinc adsorbance reach 150mg/g; Hydrophobicity contains cadmia polysaccharide non-woven fabrics and constitutes by 5 layers, and its thickness is about about 3mm, and the zinc burst size remains on 1.7 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 12mm, and porosity is 50%.
Embodiment 2:
Hydrophobicity contains cadmia polysaccharide non-woven fabrics, and adopting the chitosan non-woven fabrics of intermediate molecular weight (45000), deacetylation 60% is raw material, carries out the absorption of zinc ion behind the employing propylene polymerization (aggregate rate 200%), makes the zinc adsorbance reach 100mg/g; Hydrophobicity contains cadmia polysaccharide non-woven fabrics and constitutes by 10 layers, and its thickness is about about 7mm, and the zinc burst size remains on 1.2 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 15mm, and porosity is 60%.
Embodiment 3:
Hydrophobicity contains cadmia polysaccharide non-woven fabrics, and adopting the chitosan non-woven fabrics of intermediate molecular weight (30000), deacetylation 70% is raw material, carries out the absorption of zinc ion behind the employing propylene polymerization (aggregate rate 100%), makes the zinc adsorbance reach 50mg/g; Hydrophobicity contains cadmia polysaccharide non-woven fabrics and constitutes by 15 layers, and its thickness is about about 10mm, and the zinc burst size remains on 0.8 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 18mm, and porosity is 80%.
If contain the chitosan of metal ion antibacterial agent is the chitosan that contains copper ion; Provide technical scheme to specify as follows to this utility model: hydrophobicity cupric chitosan non-woven fabrics; Adopting the chitosan non-woven fabrics of intermediate molecular weight (30000～60000), deacetylation 50%～70% is raw material; Carry out the absorption of copper ion behind the employing propylene polymerization (aggregate rate 100%～300%), make the copper adsorbance reach 10～60mg/g; Hydrophobicity cupric chitosan non-woven fabrics constitutes by 5～15 layers, and its thickness is about about 3～10mm, and the copper burst size remains on 0.03～0.08 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 12～18mm, and porosity is 50%～80%.
Embodiment 1:
Adopting the chitosan non-woven fabrics of intermediate molecular weight (45000), deacetylation 60% is raw material, carries out the absorption of copper ion behind the employing propylene polymerization (aggregate rate 150%), makes the copper adsorbance reach 45mg/g; Hydrophobicity cupric chitosan non-woven fabrics constitutes by 10 layers, and its thickness is about about 7mm, and the copper burst size remains on 0.05 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 15mm, and porosity is 60%.
Embodiment 2:
Adopting the chitosan non-woven fabrics of intermediate molecular weight (30000), deacetylation 70% is raw material, carries out the absorption of copper ion behind the employing propylene polymerization (aggregate rate 100%), makes the copper adsorbance reach 30mg/g; Hydrophobicity cupric chitosan non-woven fabrics constitutes by 15 layers, and its thickness is about about 10mm, and the copper burst size remains on 0.03 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 18mm, and porosity is 80%.
Embodiment 3:
Adopting the chitosan non-woven fabrics of intermediate molecular weight (60000), deacetylation 50% is raw material, carries out the absorption of copper ion behind the employing propylene polymerization (aggregate rate 300%), makes the copper adsorbance reach 60mg/g; Hydrophobicity cupric chitosan non-woven fabrics constitutes by 5 layers, and its thickness is about about 3mm, and the copper burst size remains on 0.08 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 12mm, and porosity is 50%.
If contain the chitosan of metal ion antibacterial agent is the chitosan that contains silver ion; Provide technical scheme to specify as follows to this utility model: hydrophobicity argentiferous chitosan non-woven fabrics; Adopting the chitosan non-woven fabrics of intermediate molecular weight (30000～60000), deacetylation 50%～70% is raw material; Carry out the absorption of silver ion behind the employing propylene polymerization (aggregate rate 100%～300%), make silver adsorption reach 100～180mg/g; Hydrophobicity argentiferous chitosan non-woven fabrics constitutes by 5～15 layers, and its thickness is about about 3～10mm, and the silver burst size remains on 1.2～1.8 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 12～18mm, and porosity is 50%～80%.
Embodiment 1:
Hydrophobicity argentiferous chitosan non-woven fabrics, adopting the chitosan non-woven fabrics of intermediate molecular weight (60000), deacetylation 50% is raw material, carries out the absorption of silver ion behind the employing propylene polymerization (aggregate rate 300%), makes silver adsorption reach 180mg/g; Hydrophobicity argentiferous chitosan non-woven fabrics constitutes by 5 layers, and its thickness is about about 3mm, and the silver burst size remains on 1.8 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 12mm, and porosity is 50%.
Embodiment 2:
Hydrophobicity argentiferous chitosan non-woven fabrics, adopting the chitosan non-woven fabrics of intermediate molecular weight (45000), deacetylation 60% is raw material, carries out the absorption of silver ion behind the employing propylene polymerization (aggregate rate 200%), makes silver adsorption reach 140mg/g; Hydrophobicity argentiferous chitosan non-woven fabrics constitutes by 10 layers, and its thickness is about about 7mm, and the silver burst size remains on 1.5 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 15mm, and porosity is 60%.
Embodiment 3:
Hydrophobicity argentiferous chitosan non-woven fabrics, adopting the chitosan non-woven fabrics of intermediate molecular weight (30000), deacetylation 70% is raw material, carries out the absorption of silver ion behind the employing propylene polymerization (aggregate rate 100%), makes silver adsorption reach 100mg/g; Hydrophobicity contains cadmia polysaccharide non-woven fabrics and constitutes by 15 layers, and its thickness is about about 10mm, and the silver burst size remains on 1.2 μ mol/cm when guaranteeing to use
2Hydrophilic polyurethane is used to absorb the adsorbed wound fluid of chitosan non-woven fabrics, and its thickness is 18mm, and porosity is 80%.
The zoopery result shows: rabbit back diameter 5cm holostrome skin injury wound surface, and after common negative pressure (not containing novel wound-surface plaster) treatment, The average healing is 17.86 days; After adopting the novel wound-surface plaster treatment that contains zinc ion, copper ion and silver ion respectively, wound healing time was followed successively by 14.72 days, 15.49 days and 15.35 days, and all more common negative pressure treatment group significantly shortens.Explain that novel wound-surface plaster can effectively promote wound healing, shorten healing time.
Claims (7)
1. the negative pressure treatment wound-surface plaster of a metal ion antibacterial, the vacuum suction pipe that comprises spongy layer and stretch into spongy layer is characterized in that: the negative pressure treatment wound-surface plaster of said metal ion antibacterial also comprises the non-woven fabrics of combining with spongy layer.
2. the negative pressure treatment wound-surface plaster of metal ion antibacterial according to claim 1 is characterized in that: said non-woven fabrics is the chitosan non-woven fabrics.
3. the negative pressure treatment wound-surface plaster of metal ion antibacterial according to claim 2 is characterized in that: said non-woven fabrics is a hydrophobicity chitosan non-woven fabrics.
4. the negative pressure treatment wound-surface plaster of metal ion antibacterial according to claim 3 is characterized in that: said non-woven fabrics is the chitosan non-woven fabrics of hydrophobicity metal ion antibacterial.
5. the negative pressure treatment wound-surface plaster of metal ion antibacterial according to claim 4 is characterized in that: said metal ion antibacterial is to contain zinc ion antibacterial, copper ions antibacterial or contain the silver-ion antibiotic agent.
6. according to the negative pressure treatment wound-surface plaster of claim 1 or 2 or 3 or 4 or 5 described metal ion antibacterial, it is characterized in that: said non-woven fabrics is one or more layers; Preferred 5～15 layers.
7. the negative pressure treatment wound-surface plaster of metal ion antibacterial according to claim 6 is characterized in that: said spongy layer is a hydrophilic polyurethane sponge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204934214U CN202505597U (en) | 2011-12-01 | 2011-12-01 | Negative pressure therapy wound paste containing metal ion germicide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204934214U CN202505597U (en) | 2011-12-01 | 2011-12-01 | Negative pressure therapy wound paste containing metal ion germicide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202505597U true CN202505597U (en) | 2012-10-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011204934214U Expired - Fee Related CN202505597U (en) | 2011-12-01 | 2011-12-01 | Negative pressure therapy wound paste containing metal ion germicide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202505597U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430146A (en) * | 2011-12-01 | 2012-05-02 | 中国人民解放军第四军医大学 | Negative pressure treatment wound surface patch containing metal ion antibacterial agent and preparation method for patch |
| CN110101456A (en) * | 2019-04-26 | 2019-08-09 | 珠海高先手术用品科技有限公司 | Compound operation towel |
-
2011
- 2011-12-01 CN CN2011204934214U patent/CN202505597U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430146A (en) * | 2011-12-01 | 2012-05-02 | 中国人民解放军第四军医大学 | Negative pressure treatment wound surface patch containing metal ion antibacterial agent and preparation method for patch |
| CN110101456A (en) * | 2019-04-26 | 2019-08-09 | 珠海高先手术用品科技有限公司 | Compound operation towel |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121031 Termination date: 20171201 |