CN106267329B - A kind of plants essential oil gel dressing and its preparation method and application - Google Patents
A kind of plants essential oil gel dressing and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The present invention provides a kind of plants essential oil gel dressing and its preparation method and application, which includes plants essential oil and auxiliary material, and by weight, the plants essential oil includes: 1-5 parts of cinnamon oil, 1-5 parts of basil oil and 1-5 parts of turpentine oil.The present invention prepares the dressing for treating gynecological disease using carbomer as substrate using natural plants essential oil.Raw material sources are natural, at low cost, and the dressing good antimicrobial effect prepared, and processing technology is simple, at low cost, have no toxic side effect substantially, and the gel dressing of preparation has good therapeutic effect.
Description
Technical field
The present invention relates to a kind of plants essential oil gel dressings and its preparation method and application, belong to medical dressing technology neck
Domain.
Background technique
The development of antiseptic dressing is very fast, but there is also certain limitations at present, especially selects in antibacterial agent
On, drug resistance is generated since antibiotic is easy induction body, the development of antibacterial agent becomes hot spot in recent years.Chitosan etc.
Natural antimicrobial substance is primarily adapted for use in the lower situation of gradient of infection；Other antibacterial agents such as nano silver, sulfanilamide (SN) used at present is phonetic
Though the antibacterial abilities such as pyridine silver TiO2 are stronger, there is certain cytotoxicity, although using the sustained release measure such as polymer embedding
Its cytotoxicity can be reduced to a certain extent, but how to be further improved preparation method, enable antibacterial agent according to wound inflammation feelings
Condition carries out control release, and the less toxic broad-spectrum antiseptic reagent that research and development are novel, is all the direction of antiseptic dressing research effort from now on.
Vaginitis is the inflammation of connective tissue under vagina mucosa and mucous membrane, is Out-patient Clinic of Department of Gynecology common disease.Candida albicans vagina
Inflammation is also known as vulvovaginal candidiasis (VVC), and sick the main pathogenic fungi, research data show 5% woman to Candida albicans thus
Female at least suffered from this primary disease in life, and 45% women lives through 2 times or 2 times or more breaking-outs, at present on clinical treatment with
Based on the antifungals such as Miconazole, Fluconazole, clotrimazole.Due to the irrational use of antibiotic, analysis of clinic pathogenic microorganism is to existing anti-
The sensibility of fungi-medicine be decreased obviously than before, and the trend that its drug resistance makes further progress.It is anti-true with tradition
Bacterium drug is compared, and plant extract active constituent and its compound treatment vaginitis are with antifungic action is strong, curative effect is stable, toxicity is low
The advantages that being not easy drug resistance.
It now yet there are no the application report using plants essential oil compound in the gynecologies disease treatment such as vaginitis.
Summary of the invention
Present invention solves the technical problem that be, using three kinds of plants essential oils, i.e. cinnamon oil, basil oil and terebinthine
Antibacterial characteristics are applied the pharmaceutical preparation field in diseases such as women's gynecological disease, especially vaginitis.
The technical scheme is that providing a kind of plants essential oil gel dressing, including plants essential oil and auxiliary material, by weight
Part, the plants essential oil includes: 1-5 parts of cinnamon oil, 1-5 parts of basil oil and 1-5 parts of turpentine oil.
Further, the gel dressing further includes the peppermint leaf extract of 0.05-0.15 parts by weight.
Further, the gel dressing further includes the tea polyphenols of 0.01-0.03 parts by weight.
Further, the auxiliary material includes the carbomer of 1.5-2.5 parts by weight.
Further, the auxiliary material includes the glycerol of 1-3 parts by weight.
Further, the auxiliary material further include the polyethylene glycol of 0.1-0.3 parts by weight, 0.03-0.07 parts by weight 12
The polyvinylpyrrolidone of sodium alkyl benzene sulfonate and 0.03-0.07 parts by weight.
Further, the auxiliary material further includes triethanolamine and lactic acid.
The present invention further provides a kind of preparation method of plants essential oil gel dressing, comprising the following steps:
(1) by weight, by 1-5 parts of cinnamon oil, 1-5 parts of basil oil, 1-5 parts of turpentine oil, 1-3 parts sweet
Mixed liquor A is made with water in oil；Mixed liquor A is uniformly mixed, the polyethylene glycol of 0.1-0.3 parts of addition is stirred to not stratified
The tea polyphenols for adding 0.01-0.03 parts afterwards, obtain mixed liquid B；By 1.5-2.5 parts of carbomer dispersion Yu Shuizhong, mixed
Liquid C；
(2) mixed liquid B is mixed and is stirred continuously with mixed liquor C, add the detergent alkylate sulphur of 0.03-0.07 parts by weight
The polyvinylpyrrolidone of sour sodium and 0.03-0.07 parts by weight, stirring obtain mixed liquor D to not stratified；
(4) the peppermint leaf extract that 0.05-0.15 parts by weight are added in mixed liquor D, obtains mixed liquor E；
(5) pH of mixed liquor E is adjusted to 5-6 with triethanolamine, after mixing evenly with lactic acid tune pH to 4-4.5, is planted
Object essential oil gel dressing.
Further, the carbomer is Acritamer 940；The polyethylene glycol is PEG-400；The polyvinylpyrrolidine
Ketone is PVP-K30.
Above-mentioned gel dressing can be applied to preparation treatment medicine for gynecopathy, be especially applied to preparation treatment vaginitis medicine
On object.
Cinnamon oil has the special fragrance of cortex cinnamomi, has apparent fungistatic effect to bacterium, yeast and fungi, especially anti-true
Bacterium effect is very good.Cinnamon oil is conducive to the growth and breeding of beneficial bacterium lactic acid bacteria simultaneously, and then is conducive to the life of vagina lactic acid bacteria
It is long, acid vagina environment is maintained, improves microecology in vaginas balance, promotes the healing of vaginitis.Have simultaneously to a variety of dermatophytes
Apparent inhibiting effect.
Its main component of basil oil is eugenol, also containing linalool, ocimenum etc., has and inhibits bacterial growth, promotees
It is the main plant essence of Related Skin Diseases caused by many bacteriums for the treatment of and inflammation into pharmacological actions such as damaged skin normal healings
Oil.
Turpentine oil has the multiple efficacies such as anti-inflammatory analgetic, antibacterial desinsection, while mixing with cinnamon oil and basil oil, energy
It is obviously promoted the fungistatic effect of the two.
Lactic acid has very strong anti-corrosive fresh-keeping effect and hygroscopicity, has and adjusts pH value, antibacterial, holding film color and humidity etc.
Effect, while lactic acid also helps the growth of beneficial microbe lactic acid bacteria in induction woman vagina, and probiotics is caused to become advantage
Bacterial strain, to inhibit the growth and breeding for causing the harmful bacterias such as Candida albicans.
Tea polyphenols have very strong antioxidation, and oxidation resistance is the 4-6 of artificial synthesized antioxidant BHT, BHA
Times, 6-7 times of VE, 5-10 times of VC, and dosage is few, and the potential toxic side effect without synthetic；It can effectively prevent plants essential oil
Corruption, and peculiar smell can be eliminated.
Peppermint leaf extract plays the role of swelling and pain relieving, antiphlogistic antibacterial.Simultaneously refrigerant moisturizing specific to peppermint and it is fragrant
Pleasant smell come cover up and improve it is some there is peculiar smell, gel low ph conditions shouting pain caused by patient and not can also be eliminated
Suitable sense phenomenon.
Plants essential oil is applied in the gel dressing for the treatment of gynecological disease by the present invention, and it is antibacterial or kill to have widened gel dressing
The range of choice of fungus matter has obtained realizing plant extract component with fine antibacterial or bactericidal property gel dressing
High value added utilization while, provide the theory and method with reference value for the research of new type gel dressing.
The beneficial effects of the present invention are: natural plants essential oil is utilized, using carbomer as substrate, is prepared for treating woman
The dressing of section's disease.Raw material sources are natural, at low cost, and the dressing good antimicrobial effect prepared, and processing technology is simple, at low cost,
Substantially it has no toxic side effect, the gel dressing of preparation has good therapeutic effect.
Specific embodiment
Below with reference to embodiment, the invention will be further described.
Embodiment 1
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) Carbomer-940 2g 12h is impregnated with 50g water；
(2) it is stirred respectively with cinnamon oil (1g), basil oil (1g), turpentine oil (1g) and glycerol (2g) with 50g water
It is uniformly mixed, while adding 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.01g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.05g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 2
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is stirred respectively with cinnamon oil (5g), basil oil (5g), turpentine oil (5g) and glycerol (2g) with 50g water
It is uniformly mixed, while adding 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.03g.
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.0 to pH.
Embodiment 3
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is stirred respectively with cinnamon oil (3g), basil oil (3g), turpentine oil (3g) and glycerol (2g) with 50g water
It is uniformly mixed, while adding 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.02g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.1g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.4 to pH.
Embodiment 4
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is stirred respectively with cinnamon oil (3g), basil oil (3g), turpentine oil (3g) and glycerol (2g) with 50g water
It is uniformly mixed, while adding 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.01g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.05g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.3 to pH.
Embodiment 5
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is stirred respectively with cinnamon oil (3g), basil oil (3g), turpentine oil (3g) and glycerol (2g) with 50g water
It is uniformly mixed, while adding 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 6
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is uniformly mixed respectively with turpentine oil (3g) and glycerol (2g) with 50g water, while adding the poly- second two of 0.2g
Alcohol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 7
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is uniformly mixed respectively with cinnamon oil (3g) and glycerol (2g) with 50g water, while adding the poly- second two of 0.2g
Alcohol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 8
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is uniformly mixed respectively with basil oil (3g) and glycerol (2g) with 50g water, while it is poly- to add 0.2g
Ethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 9
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is uniformly mixed with cinnamon oil (3g), turpentine oil (3g) and glycerol (2g) with 50g water, is added simultaneously respectively
Add 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 10
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is uniformly mixed respectively with basil oil (3g), turpentine oil (3g) and glycerol (2g) with 50g water, together
Shi Tianjia 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Embodiment 11
The present embodiment provides a kind of plants essential oil gel dressings, the specific steps are as follows:
(1) 2g Carbomer-940 12h is impregnated with 50g water；
(2) it is uniformly mixed respectively with basil oil (3g), cinnamon oil (3g) and glycerol (2g) with 50g water, together
Shi Tianjia 0.2g polyethylene glycol 400, stirring to not stratified rear addition tea polyphenols 0.03g；
(3) solution in step (1) and step (2) is mixed, and be stirred continuously, while adding neopelex
0.05g, PVP (K30) 0.05g, stir evenly it is not stratified until；
(4) solution in step (3) is added into peppermint leaf extract 0.15g；
(5) its pH is adjusted to 5.5 or so with triethanolamine by the mixture in step (4), adds lactic acid after mixing evenly
It is 4.2 to pH.
Comparative example 1-5
Comparative test is done with five batches " fragrant pleasure is net " silver ion gel dressing product of commercial type
The different comparison of essential oil
The antibacterial data of table 1 the embodiment of the present invention 1-11 and comparative example 1-5 are as follows:
| Antibacterial circle diameter (mm) | Escherichia coli | Staphylococcus aureus | Candida albicans |
| Embodiment 1 | 19±1.35 | 23±1.64 | 20±1.21 |
| Embodiment 2 | 22±1.98 | 26±2.15 | 24±2.05 |
| Embodiment 3 | 20±1.64 | 24±1.98 | 21±1.36 |
| Embodiment 4 | 19±1.63 | 23±1.99 | 21±1.28 |
| Embodiment 5 | 18±1.75 | 22±1.87 | 23±2.10 |
| Embodiment 6 (pine) | 4.2±1.01 | 3.5±0.23 | 6.9±0.85 |
| Embodiment 7 (meat) | 10.3±1.22 | 11.5±1.13 | 12.1±1.05 |
| Embodiment 8 (fourth) | 9.8±1.11 | 10.2±1.87 | 8.9±0.65 |
| Embodiment 9 (meat+pine) | 17.2±1.32 | 18.3±1.21 | 20.6±1.32 |
| Embodiment 10 (pine+fourth) | 15.3±1.24 | 16.5±1.06 | 18.6±0.89 |
| Embodiment 11 (meat+fourth) | 15.1±1.10 | 16.0±1.02 | 18.5±1.24 |
| Comparative example 1 | 13.6±1.57 | 16.5±1.03 | 15.6±1.98 |
| Comparative example 2 | 13.2±1.27 | 17.0±1.33 | 16.1±1.45 |
| Comparative example 3 | 14.3±1.66 | 16.2±1.37 | 16.3±1.63 |
| Comparative example 4 | 15.2±1.22 | 14.3±1.31 | 13.4±1.09 |
| Comparative example 5 | 13.7±1.01 | 15.0±0.99 | 14.2±1.32 |
From the experimental data of table 1:
(1), by the data of the bacteriostatic test of the embodiment 1-5 carbomer gel dressing prepared it is found that three kinds of plants essential oils
The addition of component (cinnamon oil, basil oil, turpentine oil) and the control of concentration, are greatly improved its fungistatic effect, favorably
In its popularization and application；
(2), by the comparative example 1-5 antibacterial data prepared it is found that three kinds of plant essential oil components (cinnamon oils, clore basil
Oil, turpentine oil) additive effect outclass the antibacterial effect of the anion dressing sold in the market, functional components are all to plant
Material resource, it is highly-safe.
(3), by the data of the bacteriostatic test of the embodiment 5-11 carbomer gel dressing prepared it is found that cinnamon oil, cloves
The fungistatic effect of the single addition of basil, turpentine oil be lower than cinnamon oil+turpentine oil, basil oil+terebinthine fungistatic effect,
More below cinnamon oil+basil oil+terebinthine fungistatic effect.
(4), by the data of the bacteriostatic test of the embodiment 1-11 carbomer gel dressing prepared it is found that three kinds of essential oils can be with
Mutually collaboration, promotion is antibacterial, plays collaboration well and promotes antibacterial effect.
Claims (3)
1. a kind of preparation method of plants essential oil gel dressing, which comprises the following steps:
(1) by weight, by 1-5 parts of cinnamon oil, 1-5 parts of basil oil, 1-5 parts of turpentine oil, 1-3 parts of glycerol
Mixed liquor A is made with water；Mixed liquor A is uniformly mixed, 0.1-0.3 part of polyethylene glycol of addition, is stirred to after not stratified
The tea polyphenols of 0.01-0.03 parts of addition, obtain mixed liquid B；By 1.5-2.5 parts of carbomer dispersion Yu Shuizhong, mixed liquor is obtained
C；
(2) mixed liquid B is mixed and is stirred continuously with mixed liquor C, add the dodecyl benzene sulfonic acid of 0.03-0.07 parts by weight
The polyvinylpyrrolidone of sodium and 0.03-0.07 parts by weight, stirring obtain mixed liquor D to not stratified；
(4) the peppermint leaf extract that 0.05-0.15 parts by weight are added in mixed liquor D, obtains mixed liquor E；
(5) pH of mixed liquor E is adjusted to 5-6 with triethanolamine, after mixing evenly with lactic acid tune pH to 4-4.5, obtains plant essence
Oleogel dressing.
2. preparation method as described in claim 1, which is characterized in that the carbomer is Acritamer 940；The polyethylene glycol
For PEG-400；The polyvinylpyrrolidone is PVP-K30.
3. application of the gel dressing that preparation method of any of claims 1 or 2 obtains on preparation treatment medicine for gynecopathy.
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| CN114652773B (en) * | 2022-04-22 | 2023-05-12 | 湖南省中医药研究院 | Gynecological gel and preparation method and application thereof |
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| CN1602858A (en) * | 2003-09-30 | 2005-04-06 | 昆明紫健生物技术有限公司 | Arteannuin preparation for treating gynecopathy |
| CN1682813A (en) * | 2005-02-23 | 2005-10-19 | 黄德忠 | Chinese medicine solution agent for treating damp-heat disease and its preparing method |
| CN101181425A (en) * | 2007-11-19 | 2008-05-21 | 王雨良 | Chinese medicine externally used liniment |
| CN104208635A (en) * | 2014-09-16 | 2014-12-17 | 马昆阳 | Externally used traditional Chinese medicine composition for relieving pain and preparation method thereof |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN106176603A (en) * | 2016-08-15 | 2016-12-07 | 湖南仁馨生物技术有限公司 | A kind of plants essential oil micro emulsion gel and its preparation method and application |
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| CN1602858A (en) * | 2003-09-30 | 2005-04-06 | 昆明紫健生物技术有限公司 | Arteannuin preparation for treating gynecopathy |
| CN1682813A (en) * | 2005-02-23 | 2005-10-19 | 黄德忠 | Chinese medicine solution agent for treating damp-heat disease and its preparing method |
| CN101181425A (en) * | 2007-11-19 | 2008-05-21 | 王雨良 | Chinese medicine externally used liniment |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN104208635A (en) * | 2014-09-16 | 2014-12-17 | 马昆阳 | Externally used traditional Chinese medicine composition for relieving pain and preparation method thereof |
| CN106176603A (en) * | 2016-08-15 | 2016-12-07 | 湖南仁馨生物技术有限公司 | A kind of plants essential oil micro emulsion gel and its preparation method and application |
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