CN106668864A - External-use ointment for treatment of dermatopathy - Google Patents

External-use ointment for treatment of dermatopathy Download PDF

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CN106668864A
CN106668864A CN201610907215.0A CN201610907215A CN106668864A CN 106668864 A CN106668864 A CN 106668864A CN 201610907215 A CN201610907215 A CN 201610907215A CN 106668864 A CN106668864 A CN 106668864A
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parts
ointment
chloramphenicol
cream
vitamin
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毕明华
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

The invention relates to an external-use ointment for treatment of dermatopathy. The ointment is prepared by mixing and blending the following medicines (by weight): 6-9 parts of sulfamethoxazole, 5-8 parts of chloramphenicol, 5-8 parts of prednisone, 3-5 parts of borneol, 0-8 parts of sulfur flour, 5-8 parts of vitamin E, 4-8 parts of vitamin complex B, 6-10 parts of VC, 5-7 parts of B1, 0.01-0.04 part of triamcinolone acetonide, 10 parts of urea ointment, 30 parts of a Chinese herbal antibacterial paste, 8-10 parts of chlorpheniramine, 4-8 parts of chloramphenicol raw powder, 6-10 parts of metronidazole, 10 parts of B6 ointment, 0-15 parts of terbinafine hydrochloride emulsifiable paste and 0-10 parts of ketoconazole emulsifiable paste. The ointment of the invention is used for treatment of skin diseases such as dermatitis, eczema, acne, yellow fluid ulcers, manus and tinea pedis, psoriasis, etc., can be used for realizing antibiosis, anti-inflammation, itching-relieving and antiallergic functions and the function of boosting body immunity, reduces exudation and inflammatory response and promotes inflammatory resorption of wounds and growth of granulation tissues, and has a good comprehensive treatment effect.

Description

One kind treats dermopathic external-applied ointment
Technical field
The present invention relates to Chinese patent drug, specifically one kind treat dermopathic external-applied ointment.
Background technology
Eczema, neurodermatitis are the high dermis and epidermal inflammation caused by various internal and external factors, and the cause of disease is complicated, typically Think relevant with allergy, easy recurrent exerbation, clinically acute stage skin damaged have and ooze out tendency based on the sore rash of mound.It is internal because Element：Chronic infection focus, endocrine and metabolism change, blood circulation disorder, psychoneural factor, inherent cause；External factor： The generation of this disease can be by food（Such as fishes and shrimps, beef and mutton）, inhalation (inhalatio)（Such as pollen, dermatophagoides pteronyssinus, microorganism）, living environment（Such as Daylight, sweltering heat, drying etc.）, animal fur, various chemical substances etc. induce and increase.
The drug side-effect of the scytitises such as existing treatment eczema, neurodermatitis is larger, and effect is less obvious, holds Easily recurrence, flow process is more, high cost.
The content of the invention
In view of the deficiencies in the prior art, the present invention provides one kind and can realize antibacterial, anti-inflammatory, antipruritic, antiallergy and enhancing Body's immunity, reduction is oozed out and inflammatory reaction, promotes surface of a wound inflammatory to absorb and granulation tissue growth, reaches Synthetic curative effect The dermopathic external-applied ointment for the treatment of of fruit.
The technical solution used in the present invention is：
One kind treats dermopathic external-applied ointment, counts by weight, by agents hybrid modulation into cream：Radonil 6-9 parts； Chloramphenicol 5-8 parts；Prednisone 5-8 parts；Borneol 3-5 parts；Sofril 0-8 parts；Vitamin E 5-8 parts；The compound B 4-8 of vitamin Part；VC 6-10 parts；B1 5-7 parts；Triamcinolone acetonide 0.01-0.04 parts；10 parts of carbamide ointment；Antibacterial 30 parts of the cream of book on Chinese herbal medicine；Chlorpheniramine 8-10 parts；Chloramphenicol original powder 4-8 parts；Metronidazole 6-10 parts；10 parts of B6 ointment；Terbinafine hydrochloride emulsifiable paste 0-15 parts；Ketoconazole Emulsifiable paste 0-10 parts.
Further, by agents hybrid modulation into cream：Radonil 8g；Chloramphenicol 7g；Prednisone 5g；Borneol 4g；Sulphur Bloom 5g；Vitamin E 5g；The compound B 8g of vitamin；VC 8g；B1 6g；Triamcinolone acetonide 40mg；Carbamide ointment 10g；Book on Chinese herbal medicine is antibacterial Cream 30g；Chlorpheniramine 10g；Chloramphenicol original powder 5g；Metronidazole 8g；B6 ointment 10g；Terbinafine hydrochloride emulsifiable paste 15g；Ketoconazole breast Cream 10g.
According to the dermopathic external-applied ointment for the treatment of that above-mentioned technical proposal is provided, the pharmacological action of each medicine in its medicine composition It is described below：
Radonil：Treatment bacterial infection；
Chloramphenicol：Various severe infections caused by treatment sensitive bacterial；
Prednisone：With anti-inflammatory and anti-allergic effects, the hyperplasia of connective tissue, reduction capillary wall and cell membrane can be suppressed Permeability.Reduction is acute to ooze out, and alleviates inflammatory reaction；
Borneol：For the disease of various pruituses, there is calm anti-inflammatory；
Sofril：It is anti-dandruff, have it is antipruritic, kill bacterium, fungi, mould, acarid, parasite the effects such as, it can also be used to sore, carbuncle and painful swelling；
Vitamin E：Pachylosis can be controlled, is chapped, the treatment to chronic dermatosis reduces pigment deposition to reducing abnormal pigmentary deposit on the skin trace and anti-inflammatory Have certain effect；
Vitamin is combined B：There is certain curative effect to dermatitis and eczema, treat pachylosis；
VC：Melanin can be suppressed to produce, reduce melanin, for pigmentation spots after inflammation and desalination freckle, reduce skin effect Perception is effective to various quick dermatoses, such as dermatitis, eczema, drug rash；
Vitamin B1：Other medicines are coordinated to strengthen the curative effect of anti-inflammatory anti-itch；
Chlorpheniramine：Suitable for various allergic to dermatitis, eczema pruitus, neurodermatitis has obvious curative effects；
Metronidazole：Treatment multiple dermatosis, for anaerobic infection treatment, hinder bacterial metabolism, promote bacterial death；
Triamcinolone acetonide：There are inflammation-resisting itch-stopping, antiallergy and pressor effect, it is adaptable to dermatitis and eczema, neurodermatitis, ox-hide The chronic itch such as tinea, the treatment of anaphylaxis dermatosis；
B6 ointment：Suitable for the various skin diseases such as chapped skin, eczema, acne；
Carbamide ointment：Effect with anti-inflammatory, anti-bacterial, anti-itching, is suitable for rhagadia manus et pedis and chronic inflammation；
The antibacterial cream of book on Chinese herbal medicine：There is bacteriostasis to Escherichia coli, Candida albicans, staphylococcus aureus；
Terbinafine hydrochloride emulsifiable paste：It is fungi-medicine of new generation, with antimycotic effect, there is stronger sterilization to dermatophyte And bacteriostasis, treat shallow deep mycosis and its fungi in hypodermis infection；
Ketoconazole cream：Suitable for the skin disease of various fungal infections, be mainly used in skin superficial fungal infection, such as tinea of feet and hands, Ringworm of the body etc..
The present invention embodies above-mentioned each medicine reasonable compatibility to all kinds of dermopathic complex treatment functions, and therapeutic effect is good, Treatment cost is low.
Dermopathic curative effect is treated to illustrate the invention, and following clinical treatment data is now provided：
（1）Clinical data：Observation case totally 285, man 140, female 145, age 1-70 year, the course of disease -10 years 7 days, wherein The course of disease less than 15 days 200, -1 year 15 days 55, -10 years 1 year 30, be randomly divided into treatment group 145 and control group 140.
（2）Treatment method：
Treatment group with medicinal ointment therapy of the present invention, substantially just：Radonil 8g, chloramphenicol 7g, prednisone 5g, borneol 4g, sofril 3g, Vitamin E 5g, vitamin is combined B8g, VC8g, B1 6g, Triamcinolone acetonide 40mg, carbamide ointment 10g, herbal antibacterial cream（River Xi Bangrui bio tech ltd product, trade name：Busy bee）30g, chlorpheniramine 10g, chloramphenicol original powder 5g, metronidazole 8g, B6 ointment 10g, Terbinafine hydrochloride emulsifiable paste（Main Ingredients and Appearance 0.01g）15g, ketoconazole cream（Main Ingredients and Appearance 10mg）10g； Each medicine mixing will adjust equal above, be prepared into cream, and twice daily apply and put affected part on the skin, and take this ointment and massage absorption in right amount.
Control group uses clindamycin emulsifiable paste, twice daily.
（3）Criterion of therapeutical effect and treatment results：
Criterion of therapeutical effect is cured：Skin damaged disappears completely；Take a turn for the better：Skin damaged regression more than 50%；Do not heal：Skin damaged regression is less than 5%.
Treatment results：Treatment group and control group Clinical efficacy comparison：It is shown in Table 1.
3.3 bad reactions：Bad reaction table 1, Clinical efficacy comparison example are had no in therapeutic process
Group n Cure Take a turn for the better Do not heal Total effective rate（%）
Treatment group 145 140 4 1 99.31
Control group 140 116 6 18 87.14
It is described in synthesis, the present invention compared with prior art, with following features：Therapeutic domain is wide, and cure rate is high, treats skin The diseases such as inflammation, eczema, acne, impetigo, tinea of feet and hands, psoriasis, cure rate is up to 99%.
Specific embodiment
With reference to embodiments and model case the invention will be further described, purpose is only that and more fully understands this Bright content.Therefore, the cited case is not intended to limit protection scope of the present invention.
Embodiment 1, illness：Dermatitis.
Man, 3 weeks, name：Bi Jiaxuan, address：The Tangshan, Hebei Province Fengnan District willow circle town Xihe River, before the shin of right side, skin damaged It is just erythema, postemphasis in 3 days, sufferings substantially, are grabbed and may occur in which scratch, are formed a scab, and pachyderma, nothing is oozed out.Using ointment of the present invention： Radonil 7g, chloramphenicol 6g, prednisone 6g, borneol 3g, sofril 3g, vitamin E 6g, vitamin is combined B5g, VC7g, B1 6g, Triamcinolone acetonide 20mg, carbamide ointment 10g, herbal antibacterial cream（Jiangxi Bang Rui bio tech ltd product）30g, flutters you Quick 9g, chloramphenicol original powder 5g, metronidazole 7g, B6 ointment 10g；Medicine-feeding is adjusted and is prepared into cream, affected part is twice daily smeared, 7 days Quan Yu, has no adverse reaction.
Embodiment 2, illness：Acute eczema.
Man, 10 months, Dong Hangyu, address：The Tangshan, Hebei Province Fengnan District Dong Dai village, neck is dispersed in grain grain size papule, Mound sore rash, water sore, acute pruritus increase have new erosion face to ooze out for 5 days, purulence scab.Using ointment of the present invention：Radonil 6g, chlorine is mould Plain 5g, prednisone 5g, borneol 3g, sofril 0g vitamin E 5g vitamins are combined B4g, VC6g, B1 5g, Triamcinolone acetonide 10mg, carbamide ointment 10g, herbal antibacterial cream（Jiangxi Bang Rui bio tech ltd product）30g, chlorpheniramine 8g, chloramphenicol Former powder 4g, metronidazole 6g, B6 ointment 10g；Medicine-feeding is adjusted and is prepared into cream, twice daily smear affected part, 10 days entirely more, without bad Reaction.
Embodiment 3, illness：Chronic eczema.
Li Shengcai, man, 58 years old, address：Fengnan District willow circle, hand skin is plump, rough surface, March, feels obvious scabies Itch, in Chen Faxing, gently weigh sometimes sometimes, using ointment of the present invention：Radonil 9g；Chloramphenicol 8g, prednisone 8g, borneol 5g, sulphur Bloom 8g, vitamin E 8g, vitamin is combined B8g, VC10g, B1 7g, Triamcinolone acetonide 40mg, carbamide ointment 10g, and book on Chinese herbal medicine is antibacterial Cream（Jiangxi Bang Rui bio tech ltd product）30g, chlorpheniramine 10g, chloramphenicol original powder 8g, metronidazole 10g, B6 ointment 10g；Medicine-feeding is adjusted and is prepared into cream, twice daily smear affected part, entirely more, had no adverse reaction within 25 days.
Embodiment 4, illness：Eczema.
Li Yuxuan, female, 13 years old, there be the papule and mound sore rash being dispersed in Tangshan, Hebei Province Guye District, foot, and oozed out substantially, Conscious itch.Using ointment of the present invention：Radonil 8g, chloramphenicol 7g, prednisone 5g, borneol 4g, sofril 3g, vitamin E 5g, Vitamin is combined B8g, VC8g, B1 6g, Triamcinolone acetonide 40mg, carbamide ointment 10g, herbal antibacterial cream（The auspicious biotechnology of Jiangxi nation Co., Ltd's product）30g, chlorpheniramine 10g, chloramphenicol original powder 5g, metronidazole 8g, B6 ointment 10g；Medicine-feeding is adjusted and is prepared into Cream, twice daily smears affected part, entirely more, has no adverse reaction within 10 days.
Embodiment 5, illness：Acne.
Wang Jian, man, 20 years old, address：Tangshan Nan Bao development zones, there is the papilla being dispersed on facial inflamed papules, top, there is knot Section, tumour, when have itch, be in a bad way, ill 2 years Jing are treated without obvious curative effects, come to go to a doctor.Using ointment of the present invention：Newly The bright 9g of promise, chloramphenicol 8g, prednisone 8g, borneol 5g, sofril 8g, vitamin E 8g, vitamin is combined B8g, VC10g, B1 10g, Triamcinolone acetonide 20mg, carbamide ointment 10g, herbal antibacterial cream（Jiangxi Bang Rui bio tech ltd product）30g, flutters You are quick 10g, chloramphenicol original powder 8g, metronidazole 10g, B6 ointment 10g；Medicine-feeding is adjusted and is prepared into cream, it is secondary for one that this prepares ointment, Affected part is twice daily smeared, 6 pairs are complete more, have no adverse reaction.
Embodiment 6, illness：Psoriasis vulgaris.
Lv Baoshun, man, 64 years old, address：The Tangshan City Fengnan District Xinhe River village, Jing treatments in ill 7 years are again and again not apparent from Turn to come to go to a doctor, patient's four limbs trunk has erythema significantly not of uniform size, around there is inflammatory blush, slightly thickens, and surface is covered The lid multilayer silvery white scales of skin that peel off feels itch, and the scales of skin that peel off flies one after another in broken foam when scratching, and exposes red smooth basal plane, and peelling off film can See petechial hemorrhage.Using ointment of the present invention：Radonil 8g, chloramphenicol 7g, prednisone 5g, borneol 4g, sofril 3g, vitamin E5g, vitamin is combined B8g, VC8g, B1 6g, Triamcinolone acetonide 40mg, carbamide ointment 10g, herbal antibacterial cream（Jiangxi nation Auspicious bio tech ltd's product）30g, chlorpheniramine 10g, chloramphenicol original powder 5g, metronidazole 8g, B6 ointment 10g, hydrochloric acid is special Than naphthalene sweet smell emulsifiable paste 15g（Main Ingredients and Appearance 0.01g）, ketoconazole cream 10g（Main Ingredients and Appearance 10mg）；Medicine-feeding is adjusted and is prepared into cream, It is secondary for one that this prepares ointment, twice daily smears affected part, and 10 pairs are complete more, have no adverse reaction.
Above-described embodiment is only to explanation for example of the invention.Those skilled in the art can be right Described specific embodiment is made various modifications or supplements or substituted using similar mode, but without departing from this Bright spirit surmounts scope defined in appended claims.

Claims (2)

1. one kind treats dermopathic external-applied ointment, it is characterised in that count by weight, by agents hybrid modulation into Cream：Radonil 6-9 parts；Chloramphenicol 5-8 parts；Prednisone 5-8 parts；Borneol 3-5 parts；Sofril 0-8 parts；Vitamin E 5-8 parts；Dimension Raw element is combined B 4-8 parts；VC 6-10 parts；B1 5-7 parts；Triamcinolone acetonide 0.01-0.04 parts；10 parts of carbamide ointment；Book on Chinese herbal medicine is antibacterial 30 parts of cream；Chlorpheniramine 8-10 parts；Chloramphenicol original powder 4-8 parts；Metronidazole 6-10 parts；10 parts of B6 ointment；Terbinafine hydrochloride emulsifiable paste 0-15 parts；Ketoconazole cream 0-10 part.
2. one kind according to claim 1 treats dermopathic external-applied ointment, it is characterised in that adjusted by agents mixing Make cream：Radonil 8g；Chloramphenicol 7g；Prednisone 5g；Borneol 4g；Sofril 5g；Vitamin E 5g；The compound B 8g of vitamin；VC 8g；B1 6g；Triamcinolone acetonide 40mg；Carbamide ointment 10g；The antibacterial cream 30g of book on Chinese herbal medicine；Chlorpheniramine 10g；Chloramphenicol original powder 5g；Metronidazole 8g；B6 ointment 10g；Terbinafine hydrochloride emulsifiable paste 15g；Ketoconazole cream 10g.
CN201610907215.0A 2016-10-19 2016-10-19 External-use ointment for treatment of dermatopathy Pending CN106668864A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109010344A (en) * 2018-10-17 2018-12-18 昆明医科大学第二附属医院 A kind of preparation for treating impetigo
CN110638835A (en) * 2019-10-24 2020-01-03 李生林 External ointment for skin and preparation method thereof
CN110664642A (en) * 2019-10-24 2020-01-10 吉开平 Beautifying cream capable of diminishing inflammation, removing acnes and beautifying face as well as preparation method and application of beautifying cream
CN111096981A (en) * 2020-03-02 2020-05-05 乌力吉白尔 External-use medicine for treating various skin diseases and its preparing method
CN113456668A (en) * 2021-05-27 2021-10-01 齐万琴 External ointment for women and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679605A (en) * 2005-01-11 2005-10-12 倪明芝 Medicine for treating refractory ringworm

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679605A (en) * 2005-01-11 2005-10-12 倪明芝 Medicine for treating refractory ringworm

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109010344A (en) * 2018-10-17 2018-12-18 昆明医科大学第二附属医院 A kind of preparation for treating impetigo
CN110638835A (en) * 2019-10-24 2020-01-03 李生林 External ointment for skin and preparation method thereof
CN110664642A (en) * 2019-10-24 2020-01-10 吉开平 Beautifying cream capable of diminishing inflammation, removing acnes and beautifying face as well as preparation method and application of beautifying cream
CN111096981A (en) * 2020-03-02 2020-05-05 乌力吉白尔 External-use medicine for treating various skin diseases and its preparing method
CN113456668A (en) * 2021-05-27 2021-10-01 齐万琴 External ointment for women and preparation method thereof

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