CN109846847B - Effervescent tablet for treating animal dermatosis and preparation method thereof - Google Patents
Effervescent tablet for treating animal dermatosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of veterinary drugs, and particularly discloses an effervescent tablet for treating animal skin diseases and a preparation method thereof. The effervescent tablet comprises the following components in percentage by weight: 1-30% of chlorine dioxide matrix, 1-45% of acidifying agent, 5-40% of effervescent agent, 1-25% of coagulant, 1-10% of surfactant, 0.1-10% of cooling agent, 1-20% of stabilizer and 1-25% of emollient. The components of the effervescent tablet for treating the animal skin diseases provided by the invention have a synergistic effect, so that the aim of treating various skin diseases such as animal skin inflammation or animal acute skin inflammation is fulfilled. The effervescent tablet for treating the animal skin diseases is convenient and simple to use, convenient to transport and safe to store, is prepared at present when being used, and has an obvious effect.
Description
Technical Field
The invention relates to the technical field of veterinary drugs, in particular to an effervescent tablet for treating animal skin diseases and a preparation method thereof.
Background
In recent years, with the rapid development of the livestock breeding industry, the animal breeding industry develops rapidly, and the animal skin diseases are increased gradually. The skin diseases that are clinically common in veterinary medicine are mainly classified as: bacterial infection, fungal infection, ectoparasitic infection, metabolic skin disease, skin immunological abnormality skin disease, etc. The main causes of the fungal infection are bacterial infection, fungal infection and ectoparasite infection, the mycosis has high contact infectivity, and once outbreak occurs, the mycosis is difficult to be cured radically. On one hand, if the dairy cow group has a skin disease, nutrient substances such as feed and the like of the dairy cow are influenced, and further, the milk yield and the milk quality are influenced. On the other hand, animal fur is an indispensable wealth, and can be used for keeping out cold and keeping warm and manufacturing articles for daily use such as leather clothing, leather shoes and the like, but if infectious skin diseases occur in fur-bearing animal farms, the skin of animals can be itchy, hair can fall off, and serious animals can even fester and scab, so that the use value of the fur-bearing animal husbandry is influenced to a great extent. Therefore, the health of the skin of the animal, the living environment and the living quality of human beings are greatly influenced, and meanwhile, the prevention and treatment of the skin disease can increase the breeding income and improve the economic benefit. Therefore, the prevention and treatment of animal skin diseases are of great importance to the cost saving and cost reduction of large-scale farms.
The current treatment methods for animal skin diseases are mainly divided into two types, namely antibiotic treatment and traditional Chinese medicine treatment. However, the treatment with antibiotics in large dose and for a long time can destroy the normal flora of intestinal tract and body surface, eliminate or weaken the antagonism to fungi, and increase the chance of fungal infection. Although the traditional Chinese medicine treatment method can solve the problems, the traditional Chinese medicine treatment process has the following steps: the traditional Chinese medicine components are not enough to achieve the treatment purpose due to too low concentration, and the blood concentration is difficult to control due to long-term use under the condition of too high concentration, so that various toxic and side effects are likely to occur; the process is too complex, the labor and the material are consumed, the treatment period is too long, and the like. Therefore, the development of a medicament for treating animal skin diseases, which has high efficiency, no drug resistance, low toxicity, skin moistening and convenient use, is a technical problem to be solved in the aspect of skin disease treatment.
Disclosure of Invention
Aiming at the problems that the existing antibiotic treatment is easy to generate drug resistance, the treatment period of the traditional Chinese medicine is long and the process is complex, the invention provides the effervescent tablet for treating the animal skin diseases.
And a preparation method of the effervescent tablet for treating the animal skin diseases.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
an effervescent tablet for treating animal skin diseases comprises the following components in percentage by weight: 1-30% of chlorine dioxide matrix, 1-45% of acidifying agent, 5-40% of effervescent agent, 1-25% of coagulant, 1-10% of surfactant, 0.1-10% of cooling agent, 1-20% of stabilizer and 1-25% of emollient.
Compared with the prior art, the effervescent tablet for treating the animal skin diseases has the following advantages:
(1) the acidifying agent reacts with chlorine dioxide parent bodies to quickly release chlorine dioxide, and reacts with the effervescent agents to generate carbon dioxide gas to achieve an effervescent effect, the medicinal bath liquid is formed by utilizing the powerful sterilization effect of the chlorine dioxide, a large amount of foam generated by the effervescent tablets is maintained for a long time through the surfactant, grease secretion or pus on the skin can be brought into the foam, the purpose of stabilizing the foam is achieved, meanwhile, the surface tension of the medicinal bath liquid is sharply reduced, the diffusion of the chlorine dioxide gas is facilitated, the chlorine dioxide gas is enabled to be brought into the foam along with secretion liquid, the reaction or sterilization is carried out on the foam, the medicinal bath liquid can conveniently enter deep skin wrinkles full of hair to play a role and directly reach focuses, the omnibearing sterilization effect is achieved, and the comprehensive cure is carried out.
(2) The coagulant of the invention promotes the formation of prothrombin, accelerates the coagulation, maintains the normal coagulation time and increases the elasticity of muscle tissues; emollients inhibit inflammatory responses, promote cell proliferation; the coagulant and the emollient are matched with the medicinal bath liquid in the sterilization process, the medicinal bath liquid is sterilized, the coagulant is assisted, and the emollient is used for repairing, so that the sterilization process and the repair of the treated skin are promoted.
(3) The freshener brings mild and long-lasting cool feeling to the skin, can cover slight chlorine smell generated after the tablet is dissolved, can keep comfortable feeling of animals in the treatment process, prevents the animals from rubbing the bath lotion, and provides good skin foundation for treating the skin diseases of the animals.
The effervescent tablet for treating the animal dermatosis provided by the invention is convenient and simple to use, convenient to transport and safe to store, is prepared at present when being used, and has an obvious effect.
Preferably, the effervescent tablet for treating the animal skin diseases comprises the following components in percentage by weight: 1-25% of chlorine dioxide matrix, 15-40% of acidifier, 10-30% of effervescent agent, 1-10% of coagulant, 1-5% of surfactant, 1-8% of freshener, 3-20% of stabilizer and 5-20% of emollient.
Preferably, the effervescent tablet for treating the animal skin diseases comprises the following components in percentage by weight: chlorine dioxide precursor 18%, acidifier 35%, effervescent agent 15%, coagulant 2%, surfactant 3%, algefacient 5%, stabilizer 12% and emollient 10%.
Preferably, the chlorine dioxide precursor, the acidifying agent, the effervescent agent, the blood coagulation agent, the cooling agent, the stabilizing agent and the emollient are all powder agents, and the total water content of the powder agents is less than 0.3 wt%.
Preferably, the chlorine dioxide precursor is potassium chlorite.
Preferably, the coagulant is vitamin K3.
Vitamin K3 promotes the formation of prothrombin, accelerates blood coagulation, maintains normal blood coagulation time, increases the elasticity of muscle tissue, remarkably increases intestinal peristalsis, and has the functions of promoting urination, strengthening the detoxification of liver and lowering blood pressure.
Preferably, the acidulant is mandelic acid.
The mandelic acid reacts with the chlorine dioxide matrix and the effervescent agent, and can shrink pores at the focus position, inhibit bacteria regeneration, whiten skin, promote metabolism and make animal fur smooth and water-like in the process of sterilizing the medicinal bath liquid generated by the effervescent agent.
Preferably, the effervescent agent is anhydrous potassium carbonate.
The medicinal bath liquid generated by the effervescent agent can also contain free potassium ions, and the potassium ions maintain the normal osmotic pressure and acid-base balance of body fluid, maintain the metabolism of cells and ensure the health of animals.
Preferably, the surfactant is polyoxyethylene lauryl ether, such as benzyl 35.
The surfactant benzyl 35 is a nonionic surfactant, has moderate viscosity and fluidity, is beneficial to uniform distribution of medicaments, is nonionic, and has performance not influenced by the pH of a system, the formed foam can be maintained for a long time due to the increase of the viscosity of the solution, and grease secretion or pus on the skin can be brought into the foam, so that the purpose of stabilizing the foam is achieved, meanwhile, the surface tension of the solution is sharply reduced, the diffusion of chlorine dioxide gas is facilitated, the chlorine dioxide gas enters the foam along with secretion liquid, the foam is subjected to reaction or sterilization, the foam is convenient to enter the deep part of skin folds filled with the hair to play a role, and the foam can be contacted with all corners to achieve the all-round sterilization effect.
Preferably, the cooling agent is L-menthyl lactate.
The L-menthyl lactate is an excellent freshener for perfectly replacing mint, does not have strong irritation and strong volatility of mint, can bring mild and long-term cool experience to skin, has slight mint smell, can cover slight chlorine smell generated after the tablet is dissolved, and enables animals to keep comfortable feeling in the treatment process.
Preferably, the stabilizer is anhydrous calcium chloride.
The anhydrous calcium chloride has the effect of drying materials, so that the system is more stable, and the quality guarantee period of the medicine is prolonged.
Preferably, the emollient is shikonin.
Alkannin has antibacterial, antiinflammatory, and antiviral effects, and can inhibit inflammatory reaction, promote cell proliferation and inhibit paralysis formation, so as to remove necrotic tissue and promote granulation, and can be used in combination with blood coagulation agent and bath lotion in sterilization process, and the bath lotion has sterilization effect, and the blood coagulation agent and emollient have adjuvant effect, and the emollient also has repairing effect, and can promote sterilization process and repair of skin after treatment.
Preferably, the effervescent tablet for treating the animal skin diseases further comprises a negative carrier, and the mass ratio of the addition amount of the negative carrier to the surfactant is 0.8-1.2: 0.8-1.2.
Preferably, the loading agent is light magnesium carbonate.
Further, the invention also provides a preparation method of the effervescent tablet for treating the animal skin diseases, which at least comprises the following steps:
step a, weighing the components according to the raw material ratio;
b, carrying out first mixing treatment on the chlorine dioxide matrix and the stabilizer to obtain a first mixture;
c, carrying out second mixing treatment on the surfactant and the loading agent to obtain a second mixture;
d, carrying out third mixing treatment on the second mixture, the coagulant, the freshener, the acidifier, the emollient and the effervescent agent to obtain a third mixture;
and e, carrying out fourth mixing treatment on the third mixture and the first mixture, and tabletting to obtain the effervescent tablet for treating the animal skin diseases.
Compared with the prior art, the preparation method of the effervescent tablet for treating the animal skin diseases is simple, the process is easy to control, and the effervescent tablet is suitable for industrial large-scale production and use.
Preferably, the tabletting is carried out under the conditions that the relative humidity is 20-40% and the tabletting pressure is 10-30KN, and the hardness of the effervescent tablet is 7-8.
Preferably, in the step b, the treatment time of the first mixed material is 10-20 min.
Mixing for 10min to uniformly distribute a layer of stabilizer film on the surface of the chlorine dioxide parent, wherein the film is stable and has poor permeability, and can effectively prevent the acidifying agent from contacting with the chlorine dioxide parent to obtain the coated chlorine dioxide parent.
Preferably, in the step c, the treatment time of the second mixed material is 8-20 min.
Preferably, in the step d, the processing time of the third mixed material is 10-20 min.
Preferably, in the step e, the treatment time of the fourth mixed material is 10-20 min.
Furthermore, the effervescent tablet for treating the animal skin diseases provided by the invention is used for treating various skin diseases such as animal skin diseases, skin inflammations or animal acute skin inflammations.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The embodiment of the invention provides an effervescent tablet for treating animal skin diseases, which comprises the following components in percentage by weight: the composite material comprises 18% of chlorine dioxide matrix, 35% of acidifier, 15% of effervescent agent, 2% of coagulant, 1.5% of surfactant, 5% of freshener, 12% of stabilizer, 10% of emollient and 1.5% of loading agent.
Wherein the chlorine dioxide parent substance is potassium chlorite; the coagulant is vitamin K3; the acidifying agent is mandelic acid; the effervescent agent is anhydrous potassium carbonate; the surfactant is polyoxyethylene lauryl ether; the refrigerant is L-menthyl lactate; the stabilizer is anhydrous calcium chloride; the emollient is alkannin; the carrier is light magnesium carbonate.
The preparation method of the effervescent tablet for treating the animal skin diseases comprises the following steps:
step a, weighing the components according to the raw material ratio;
b, adding the chlorine dioxide matrix and the stabilizer into a V-shaped mixer to perform first mixing treatment for 10min to obtain a first mixture;
step c, carrying out second mixing treatment on the surfactant and the loading agent for 10min according to the mass ratio of 1:1 to obtain a second mixture;
d, carrying out third mixing treatment on the second mixture, the coagulant, the freshener, the acidifier, the emollient and the effervescent agent for 20min to obtain a third mixture;
and e, carrying out fourth mixed material treatment on the third mixed material and the first mixed material for 10min, and carrying out tabletting under the conditions that the relative humidity is 30% and the tabletting pressure is 20KN to obtain the effervescent tablet with the hardness of 8 and used for treating the animal skin diseases.
Example 2
The embodiment of the invention provides an effervescent tablet for treating animal skin diseases, which comprises the following components in percentage by weight: 15% of chlorine dioxide matrix, 34% of acidifying agent, 25% of effervescent agent, 4% of coagulant, 1.5% of surfactant, 3% of cooling agent, 6% of stabilizing agent, 10% of emollient and 1.5% of loading agent.
Wherein the chlorine dioxide parent substance is potassium chlorite; the coagulant is vitamin K3; the acidifying agent is mandelic acid; the effervescent agent is anhydrous potassium carbonate; the surfactant is polyoxyethylene lauryl ether; the refrigerant is L-menthyl lactate; the stabilizer is anhydrous calcium chloride; the emollient is alkannin; the carrier is light magnesium carbonate.
The preparation method of the effervescent tablet for treating the animal skin diseases comprises the following steps:
step a, weighing the components according to the raw material ratio;
b, carrying out first mixed material treatment on the chlorine dioxide matrix and the stabilizer for 20min to obtain a first mixed material;
step c, carrying out second mixing treatment on the surfactant and the loading agent for 20min according to the mass ratio of 1:1 to obtain a second mixture;
d, carrying out third mixing treatment on the second mixture, the coagulant, the freshener, the acidifier, the emollient and the effervescent agent for 10min to obtain a third mixture;
and e, carrying out fourth mixed material treatment on the third mixed material and the first mixed material for 20min, and tabletting under the conditions that the relative humidity is 40% and the tabletting pressure is 20KN to obtain the effervescent tablet with the hardness of 7 and used for treating the animal skin diseases.
Comparative example 1
The present comparative example provides an effervescent tablet for treating skin diseases in animals, characterized in that: the paint comprises the following components in percentage by weight: the composite material comprises 18% of chlorine dioxide matrix, 35% of acidifier, 15% of effervescent agent, 2% of coagulant, 1.5% of surfactant, 5% of freshener, 12% of stabilizer, 10% of emollient and 1.5% of loading agent.
Wherein the chlorine dioxide parent substance is potassium chlorite; the coagulant is vitamin K3; the acidifier is potassium dihydrogen phosphate; the effervescent agent is anhydrous potassium carbonate; the surfactant is polyoxyethylene lauryl ether; the refrigerant is L-menthyl lactate; the stabilizer is anhydrous calcium chloride; the emollient is alkannin; the carrier is light magnesium carbonate.
The preparation method of the effervescent tablet for treating the animal skin disease of the comparative example is as described in example 1 and is not repeated.
Comparative example 2
The present comparative example provides an effervescent tablet for treating skin diseases in animals, characterized in that: the paint comprises the following components in percentage by weight: the composite material comprises 18% of chlorine dioxide matrix, 35% of acidifier, 15% of effervescent agent, 2% of coagulant, 1.5% of surfactant, 5% of freshener, 12% of stabilizer, 10% of emollient and 1.5% of loading agent.
Wherein the chlorine dioxide parent substance is potassium chlorite; the coagulant is vitamin K3; the acidifying agent is mandelic acid; the effervescent agent is zinc carbonate; the surfactant is polyoxyethylene lauryl ether; the refrigerant is L-menthyl lactate; the stabilizer is anhydrous calcium chloride; the emollient is alkannin; the carrier is light magnesium carbonate.
The preparation method of the effervescent tablet for treating the animal skin disease of the comparative example is as described in example 1 and is not repeated.
Comparative example 3
The present comparative example provides an effervescent tablet for treating skin diseases in animals, characterized in that: the paint comprises the following components in percentage by weight: the composite material comprises 18% of chlorine dioxide matrix, 35% of acidifier, 15% of effervescent agent, 2% of coagulant, 1.5% of surfactant, 5% of freshener, 12% of stabilizer, 10% of emollient and 1.5% of loading agent.
Wherein the chlorine dioxide parent substance is potassium chlorite; the coagulant is vitamin K1; the acidifying agent is mandelic acid; the effervescent agent is anhydrous potassium carbonate; the surfactant is polyoxyethylene lauryl ether; the refrigerant is L-menthyl lactate; the stabilizer is anhydrous calcium chloride; the emollient is alkannin; the carrier is light magnesium carbonate.
The preparation method of the effervescent tablet for treating the animal skin disease of the comparative example is as described in example 1 and is not repeated.
Comparative example 4
The present comparative example provides an effervescent tablet for treating skin diseases in animals, characterized in that: the paint comprises the following components in percentage by weight: the composite material comprises 18% of chlorine dioxide matrix, 35% of acidifier, 15% of effervescent agent, 2% of coagulant, 1.5% of surfactant, 5% of freshener, 12% of stabilizer, 10% of emollient and 1.5% of loading agent.
Wherein the chlorine dioxide parent substance is potassium chlorite; the coagulant is vitamin K3; the acidifying agent is mandelic acid; the effervescent agent is anhydrous potassium carbonate; the surfactant is polyoxyethylene lauryl ether; the refrigerant is L-menthyl lactate; the stabilizer is anhydrous calcium chloride; the emollient is herba Taraxaci extract; the carrier is light magnesium carbonate.
The preparation method of the effervescent tablet for treating the animal skin disease of the comparative example is as described in example 1 and is not repeated.
Test example 1
The effervescent tablet for treating animal skin diseases has the following clinical effects:
and (3) experimental design: taking a cow as an example, 240 cows with acute dermatitis were divided into 8 groups of 30 cows. Wherein 1 group is a control group with diseases, and is fed with common feed, and the infected part is cleaned with 37-40 deg.C warm water without administration; the other 1 group is a commercial effervescent tablet treatment group, and is fed with common feed, the skin of the infected position is fully cleaned by warm water with the temperature of 37-40 ℃, and the commercial effervescent tablet is dissolved in the water for carrying out scrubbing treatment on the skin of the sick dairy cows; the other 6 groups were experimental groups, and were fed with ordinary feed, the affected area was thoroughly cleaned of skin with warm water at 37-40 ℃, and the effervescent tablets prepared in examples 1-2 and comparative examples 1-4 were dissolved by effervescence in water, and the skin of the affected cows was subjected to scrub treatment, and the skin condition of each group of cows was observed, and the results are shown in table 1.
Administration standard: the weight of the commercially available effervescent tablets and the effervescent tablets prepared in examples 1-2 and comparative examples 1-4 is 1.0g, each tablet is dissolved in 1000mL of water for effervescent dissolution, 2 tablets are taken each time, 1 time is taken each day, 3 times is taken as a treatment course, and 3 treatment courses are taken.
The judgment standard of the curative effect is as follows:
and (3) healing: all hairs are rich and soft, have no pruritus behavior, and have no pus and scab;
the method has the following advantages: part of the hair is rich and soft, part of the hair has pruritus behavior, and part of the hair has no pus and scabs;
and (4) invalidation: sparse and lumpy hair, persistent itching, pus discharge and scabbing.
Effective rate (number of healings + effective number)/total number of cases
TABLE 1
As can be seen from table 1, the effervescent tablets for treating animal skin diseases prepared in examples 1-2 of the present invention have an effective rate of up to 100%, wherein the cure rate for hair is up to 99%, the cure rate for skin itching is 100%, and the cure rate for pus and scab is up to 96.7%, and the clinical effects thereof are far higher than those of comparative examples 1-4, the commercially available effervescent tablet treatment groups and the diseased control groups.
The clinical data comparison in table 1 shows that the components of the effervescent tablet for treating the animal skin diseases provided by the invention are synergistic with each other, so that the aim of treating various skin diseases such as animal skin inflammation or animal acute skin inflammation is fulfilled.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. An effervescent tablet for treating skin diseases in animals, characterized in that: the paint comprises the following components in percentage by weight: 1-30% of chlorine dioxide matrix, 1-45% of acidifying agent, 5-40% of effervescent agent, 1-25% of coagulant, 1-10% of surfactant, 0.1-10% of freshener, 1-20% of stabilizer and 1-25% of emollient, wherein the coagulant is vitamin K3, the emollient is alkannin, the chlorine dioxide matrix is potassium chlorite, the acidifying agent is mandelic acid, the effervescent agent is anhydrous potassium carbonate, the surfactant is polyoxyethylene lauryl ether, the freshener is L-menthyl lactate, and the stabilizer is anhydrous calcium chloride.
2. The effervescent tablet for treating a skin condition in an animal according to claim 1, wherein: the paint comprises the following components in percentage by weight: 1-25% of chlorine dioxide matrix, 15-40% of acidifier, 10-30% of effervescent agent, 1-10% of coagulant, 1-5% of surfactant, 1-8% of freshener, 3-20% of stabilizer and 5-20% of emollient.
3. The effervescent tablet for treating a skin condition in an animal according to claim 2, wherein: the paint comprises the following components in percentage by weight: chlorine dioxide precursor 18%, acidifier 35%, effervescent agent 15%, coagulant 2%, surfactant 3%, algefacient 5%, stabilizer 12% and emollient 10%.
4. The effervescent tablet for treating skin disorders in animals according to any one of claims 1 to 3, wherein: the chlorine dioxide matrix, the acidifier, the effervescing agent, the coagulant, the freshener, the stabilizer and the emollient are all powder, and the total water content of the powder is less than 0.3 wt%.
5. The effervescent tablet for treating skin disorders in animals according to any one of claims 1 to 3, wherein: the surfactant-containing emulsion also comprises a loading agent, and the mass ratio of the loading agent to the surfactant is 0.8-1.2: 0.8-1.2.
6. The effervescent tablet for treating a skin condition in an animal according to claim 5, wherein: the loading agent is light magnesium carbonate.
7. A preparation method of effervescent tablets for treating animal skin diseases is characterized by comprising the following steps: at least comprises the following steps:
a, weighing the components according to the raw material proportion of any one of claims 1 to 6;
b, carrying out first mixing treatment on the chlorine dioxide matrix and the stabilizer to obtain a first mixture;
c, carrying out second mixing treatment on the surfactant and the loading agent to obtain a second mixture;
d, carrying out third mixing treatment on the second mixture, the coagulant, the freshener, the acidifier, the emollient and the effervescent agent to obtain a third mixture;
and e, carrying out fourth mixing treatment on the third mixture and the first mixture, and tabletting to obtain the effervescent tablet for treating the animal skin diseases.
8. The process for preparing an effervescent tablet for the treatment of skin disorders in animals according to claim 7, wherein: tabletting under the conditions that the relative humidity is 20-40% and the tabletting pressure is 10-30KN, and the hardness of the effervescent tablet is 7-8;
in the step b, the first mixed material is treated for 10-20 min;
in the step c, the processing time of the second mixed material is 8-20 min;
in the step d, the processing time of the third mixed material is 10-20 min;
in the step e, the processing time of the fourth mixed material is 10-20 min.
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| EP2730280B1 (en) * | 2012-11-08 | 2018-05-09 | Symrise AG | A menthane carboxamide for the treatment of skin inflammation |
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| CN101600348A (en) * | 2006-12-04 | 2009-12-09 | S.K.药物公司 | The Synergistic antimicrobial preparations that comprises chlorite and hydrogen peroxide |
| CN101228868A (en) * | 2008-02-27 | 2008-07-30 | 河北科技大学 | Unitary solid chlorine dioxide effervescent tablet and preparation method thereof |
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| CN105663201A (en) * | 2016-01-19 | 2016-06-15 | 李娜 | Formula for erosion removal vaginal effervescent tablets and process for preparing same |
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