CN104138390A - Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof - Google Patents
Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a chlorine dioxide effervescent tablet for killing barbier bacteria and fungi. The chlorine dioxide effervescent tablet comprises the following components in percentage by weight: 3-15% of chlorite, 5-30% of drying agent, 3-25% of activating agent, 2-15% of solid acid, 4-15% of bonding agent, 0.5-3% of surfactant, 0.5-5% of effervescing agent, 1-12% of demolding agent and 1-25% of catalysts. The chlorine dioxide effervescent tablet has the technical effects that the tablet is gradually dissolved from outside to inside when being dissolved in water; relevant components can be dissolved and reacted at the same time; a carbon dioxide gas is generated in the dissolution process, so that the dissolution speed of the table is accelerated on one hand, and on the other hand a partial effervescence effect is achieved; due to the adopted cationic surfactant, the sterilization effect of the generated chlorine dioxide is further improved; active catalysts, including aluminum trichloride and sodium persulfate, are further introduced under the neutral condition, so that a generated chlorine dioxide sterilization solution is neutral, and the irritation and corrosion to a sterilized object are alleviated.
Description
Technical field
The present invention relates to a kind ofly soluble in waterly can produce effervescent tablet of chlorine dioxide and preparation method thereof.
Background technology
Beriberi (tinea pedis) is the foot dermatosis being caused by pathogenic fungus, has infectiousness.Tinea pedis is widely popular in the whole world, more general in tropical and subtropical zone area.Sickness rate in China's tinea pedis is very high, reaches more than 70%.Tinea pedis is also a kind of chronic infection, and fungi autoeciousness is growth and breeding in keratodermatitis, and needs of patients long-term prescription could be cured, and relapse rate is also high.More domestic medical institutions all adopt Chinese medicine and sterilization ointment to treat, be mainly the general control based on to beriberi conditions of patients, reach a kind of method of maintenance treatment, can not solve the object of beriberi patient non-relapse after healing.
Chlorine dioxide be internationally recognized the 4th generation disinfectant, the A1 level wide spectrum that World Health Organization (WHO) (WHO) and the World Food Programme (FAO) confirm, safety, efficient disinfectant, now be widely used in the sterilization of the numerous areas such as drinking water, food processing, environmental health, health care, and in clinical treatment for skin care liquid, cleaning agent and disinfectant, be directly used in human body both at home and abroad and start from dermatosis, obtained abroad multinomial patent: make the US.Pat.4035483 that has Bunyan (1997-7) of skin clean and the US.Pat.4737307 of Alliger; The US.Pat.4084747 that has Alliger (1978) for the treatment of skin injury and seat skin ulcer; The US.Pat.4956184 that has Krossr (1990-9) for the treatment of herpes, fungal infection.Domestic existing several patents for tinea pedis, collutory and product, antibacterial, the fungal infection such as halitosis, oral ulcer, tinea pedis, scabies, psoriasis, psoriasis, eczema, the dandruff, hemorrhoid, varicose ulcer, wound, acne, genital herpes, leg ulcer (US.Pat.902575) are treated to anti-intersection to these patents and concurrent infection is all obtained good result.Some chlorine dioxide products, are mostly liquid preparation and powdery product in the market, use procedure inconvenient operation, loaded down with trivial details, and chlorine dioxide in use need activation, caused chlorine dioxide bulk diffusion more, also affected result of use.Domestic existing patent discloses the solid compressed block that comprises tablet and other shapes, can produce chlorine dioxide, and produce aqueous solution of chlorine dioxide after the solid mixtures such as described tablet contact with water.Chinese patent CN200810054571.8 has proposed monobasic chlorine dioxide effervescent tablet and preparation method thereof, and effervescent tablet rear conversion rate of chlorine dioxide soluble in water related in this system is not high, the frangible shortcoming such as powder of tablet in product stock process.Chinese patent CN1590281A has proposed a kind of chlorine dioxide generation structure containing chlorite and solid hydrochlorate, wherein relates to the preparation of tablet.But this system does not relate to adding of catalyst, when tablet is in water in course of dissolution, material system is reacted and the speed that produces chlorine dioxide will reduce greatly.The precondition that the chlorite conversion ratio of explaining reaches more than 90% is that tablet dissolved just can be obtained in the water of 10-100 times of weight.Chinese patent CN1565192A discloses a kind of preparation method of monobasic tablet disinfection agent of chlorine dioxide, make monobasic powder, stabilizing agent, desiccant, forming agent and releasing agent that material comprises chlorine dioxide content 8---10%, monobasic chlorine dioxide powder accounts for the 20---50% of weight in material system, the tablet content of producing is low, is less than below 5%.
Summary of the invention
The problem to be solved in the present invention is to provide a kind of effervescent tablet that produces chlorine dioxide that can dissolve rapidly after water-soluble, and this effervescent tablet dissolution velocity is fast, and stability, conversion rate of chlorine dioxide is high, sterilizing ability is strong.
For solving the problems of the technologies described above, the present invention is achieved by the following technical solutions;
For killing a chlorine dioxide effervescent tablet for beriberi antibacterial, fungus, it comprises following component by weight;
Described described chlorite is a kind of of chlorous alkali metal or alkali salt.
Described solid acid is citric acid or tartaric acid.
Described activator is a kind of of sodium dichloro cyanurate or sodium trichloro-isocyanurate.
Described catalyst is aluminum chloride or sodium peroxydisulfate.
Described desiccant is a kind of of calcium chloride, magnesium sulfate or sodium sulfate.
Described surfactant is cationic surfactant.
Described cationic surfactant is western pyrrole chloramines.
Described binding agent is a kind of of polyvinylpyrrolidone, copolyvidone (PVP/VA64) or low-substituted hydroxypropyl cellulose (L-HPC).
Described releasing agent is a kind of of microcrystalline Cellulose, boric acid, sodium chloride or micropowder silica gel.
Described effervescent is a kind of carbonate of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate or magnesium carbonate.
For killing the antibacterial of beriberi,, a manufacture method for the chlorine dioxide effervescent tablet of fungus, it comprises the following steps;
1), first described each component raw material is put into respectively to exsiccator, be warming up to 80～90 ℃ dry, until water content, reach 1% discharging when following, be respectively charged in damp proof plastic inner lining bag standby;
2), by chlorite, solid acid, activator, catalyst, binding agent, effervescent, releasing agent, surfactant, in pulverizer and concussion sieve, pulverize respectively, sieve; Sodium chlorite 20～60 orders, solid acid 20～60 orders, activator 80～100 orders, catalyst 30～40 orders, desiccant 80～100 orders, surfactant 100～200 orders, effervescent 30～60 orders, releasing agent 100～200 orders, binding agent 80-100 orders; The raw material of pulverizing, the granularity of sieving is qualified has been respectively charged in damp proof plastic inner lining bag standby;
3), in blender, add sodium chlorite, after adding again effervescent, surfactant and desiccant, releasing agent fully to mix, add again activator, catalyst, binding agent, after finally adding solid acid to mix, discharging is pressed into effervescent tablet on tablet machine, and tabletting operating environment relative humidity is controlled at below 40%;
4), use material or the container of high-barrier, lucifuge to pack effervescent tablet.
The present invention has following technique effect: 1, a kind ofly for killing chlorine dioxide effervescent tablet ecto-entad when water dissolves of beriberi antibacterial, fungus, progressively dissolve, related component in tablet can be realized limit and dissolve just reaction, tablet produces a certain amount of carbon dioxide in course of dissolution, can accelerate the dissolution velocity of tablet on the one hand, produce on the other hand local effervescent effect; Cationic surfactant, in foot bath process, can make the chlorine dioxide antiseptic effect producing further strengthen, activating catalyst aluminum chloride, sodium peroxydisulfate under neutrallty condition have also been introduced, make the disinfection by chlorine dioxide solution producing reach neutral, reduced the zest of sterilization objects and corrosivity.So chlorine dioxide effervescent tablet of the present invention is still all having a clear superiority in aspect bactericidal effect aspect ease of use, safety.2, binding agent mainly plays the degree of adhesion increasing between raw material, makes the tablet hardness of extrusion high, is difficult for crispy slice.3, releasing agent refers to mobility in order to increase feed particles, reduces the tablet frictional force of tablet between die wall and material of adding when depanning, and the sodium chloride that preferred flow is good is releasing agent.When 4, effervescent dissolves in water and acid reaction produce carbon dioxide, produce local effervescent effect, in tablet surrounding, to dissolving the reactant, produce agitation effects, can also accelerate tablet dissolved process, further improve product stability.5, cationic surfactant is the western pyrrole chloramines of azonia surfactant, preferred western pyrrole chloramines in the present invention, and western pyrrole chloramines relies on and reduces surface tension, causes that cell membrane is disorderly, reaches lasting sterilization, antibacterial object.6, of the present invention described a kind of soluble in water and dissolved completely in 10 minutes for killing the chlorine dioxide effervescent tablet of beriberi antibacterial, fungus, soluble in waterly can discharge rapidly chlorine dioxide, and obtain clarification, approach neutral ClO 2 solution.7, of the present invention a kind of for killing the chlorine dioxide effervescent tablet of beriberi antibacterial, fungus, use pure aluminum foil bag or damp proof high-barrier plastic bag to pack product, in temperature, be greater than 54 degrees Celsius, relative humidity and be greater than under 75% environment and place 14 days, chlorine dioxide content rate of descent 6%.
Specific implementation method
Below in conjunction with embodiment, the present invention is described in further detail
The main quality index of product detects
1, chlorine dioxide content detects
(1) accurately take the weight of tablet, be dissolved in adding in 1000 ml waters.Water container is the brown volumetric flask of lucifuge.Now there is rapidly bubble and produce yellow chlorine dioxide, and in 15min, dissolve complete in tablet.Jolt after volumetric flask makes content evenly and sampling.
(2) in the iodine flask of 500ml, add 100ml distilled water, appropriate phosphate buffer, draw 10-50ml ClO 2 solution, add 10ml liquor kalii iodide again, mix, the pH value of measuring solution with acidity detector remains on 7 left and right (regulating pH value with phosphate buffer).With 0.01mol/L sodium thiosulfate, be titrated to when faint yellow, add 1ml starch solution, till continuing to drop to blueness and just disappearing, recording reading is A.
(3) in going out the solution of A value, above-mentioned titration adds again 2.5mol/L hydrochloric acid solution 2.5mL, and the 5min that opens in dark place.With 0.01mol/L sodium thiosulfate volumetric solution, drop to blue disappearance, recording reading is B.
(4) in 500ml iodine flask, add 100ml distilled water, appropriate phosphate buffer, drawing 50ml ClO 2 solution or diluent is added in iodine flask, then passing into High Purity Nitrogen air-blowing to yellow green disappears, about 20min left and right, add again 10ml liquor kalii iodide greatly, when extremely faint yellow with 0.01mol/L sodium thiosulfate volumetric solution, add 1mL starch solution, till continuing to drop to blueness and just disappearing, recording reading is C.
(5) in going out the solution of C value, above-mentioned titration adds again 2.5mol/L hydrochloric acid solution 2.5ml, and the 5min that opens in dark place.With 0.01mol/L sodium thiosulfate volumetric solution, be titrated to blue disappearance, recording reading is D.Repeat to survey twice, go twice meansigma methods to carry out following calculating.
(6) calculate
CLO2(mg÷L)＝(B-D)×c×16863÷V
Cl2(mg÷l)＝{A-(B-D)/4}×c×35450÷V
In formula; A, B, C, D are sodium thiosulfate volumetric solution consumption in above steps, ml; V is the sample volume of chlorine dioxide, mL; C is the concentration of sodium thiosulfate volumetric solution, moL/L.
2, chlorine dioxide chemical yield calculates;
Chemical yield=(the chlorite molal quantity in the chlorine dioxide molal quantity/tablet producing) X100%
Note; Technical grade sodium chlorite is used in the industry preparation of tablet, and content is more than or equal to 80%; The theoretical chemistry productive rate that sodium chlorite reacts generation chlorine dioxide under sour effect is 80%.
3, product stock Detection of Stability
Carry out 54 degrees Celsius of hot accelerated stability tests.In temperature, be greater than 54 degrees Celsius, relative humidity and be less than or equal under 75% environmental condition, packaged product is preserved 14 days, according to above-mentioned chlorine dioxide content detection method, detect effective ingredient (chlorine dioxide) content rate of descent.
Embodiment 1
The tablet of preparing 4 grammes per square metres with following formula.
| Material name (kilogram) | Proportioning raw materials |
| Sodium chlorite (80% content) | 10 |
| Sodium dichloro cyanurate | 5 |
| Magnesium sulfate | 3 |
| Sodium chloride | 32 |
| Aluminum chloride | 4.5 |
| PVP/VA64 | 3 |
| Citric acid | 39 |
| Sodium bicarbonate | 3 |
| Western pyrrole chloramines | 0.5 |
First above-mentioned each raw material components is put into respectively to exsiccator dry, be warming up to 90 ℃, until intermediate moisture, be controlled at 1% discharging when following, and after pulverizer and concussion sieve pulverize and sieve, be respectively charged in damp proof plastic inner lining bag bucket or airtight Plastic Drum standby.
First to the sodium chlorite that adds 10 kilograms in blender, add again the sodium bicarbonate of 3 kilograms, western pyrrole chloramines and the magnesium sulfate of 3 kilogram weights, the sodium chloride of 32 kilogram weights of 0.5 kilogram fully to mix after 10～20 minutes, add again the sodium dichloro cyanurate of 5 kilogram weights, add 4.5 kilogram weights of aluminum chlorides, add the PVP/VA64 of 3 kilogram weights, finally add the solid acid of 39 kilogram weights to mix discharging after 15～20 minutes, be incorporated with in the bucket or airtight Plastic Drum of plastic inner lining bag, obtain 100 kilograms of chlorine dioxide effervescent tablet combination raw materials.
Combination raw materials uses the drift of 25mm with the pressure tabletting of 60KN on tablet machine, is pressed into the tablet of 4 grams, uses pure aluminum foil bag or high-barrier anti-rot plastic bag packing.
4 grams of tablets are dropped in 2 liters of tap waters, and after 20 minutes, sampling detection aqueous solution of chlorine dioxide concentration is 27.25mg/L, and chlorine dioxide productive rate is 63%, and solution pH value is 7.0.
In temperature, be more than or equal to 54 degrees Celsius, relative humidity is greater than in 75% calorstat, and packaged titanium dioxide chlorine tablets are placed 14 days, and chlorine dioxide content rate of descent is 3.2%.
Embodiment 2
The tablet of preparing 1 grammes per square metre with following formula.
| Material name (kilogram) | Proportioning raw materials |
| Sodium chlorite (80% content) | 20 |
| Sodium dichloro cyanurate | 10 |
| Magnesium sulfate | 2 |
| Sodium chloride | 19 |
| Aluminum chloride | 3 |
| L－HPC | 2.5 |
| Citric acid | 39 |
| Sodium bicarbonate | 2 |
| Western pyrrole chloramines | 0.5 |
| Sodium peroxydisulfate | 2 |
First above-mentioned each raw material components is put into respectively to exsiccator dry, be warming up to 90 ℃, until intermediate moisture, be controlled at 1% discharging when following, and sieve and pulverize and sieve through pulverizer and concussion, be respectively charged in damp proof plastic inner lining bag bucket or airtight Plastic Drum standby.
First to the sodium chlorite that adds 20 kilograms in blender, the sodium bicarbonate that adds again 2 kilograms, the western pyrrole chloramines of 0.5 kilogram and the magnesium sulfate of 2 kilogram weights, the sodium chloride of 19 kilogram weights fully mixed after 10～20 minutes, the sodium dichloro cyanurate that adds again 10 kilogram weights, add 3 kilogram weights of aluminum chlorides, the L-HPC that adds 2.5 kilogram weights, the sodium peroxydisulfate that adds 2 kilograms, finally add the solid acid of 39 kilogram weights to mix discharging after 15～20 minutes, be incorporated with in the bucket or airtight Plastic Drum of plastic inner lining bag, obtain 100 kilograms of chlorine dioxide effervescent tablet combination raw materials.
Combination raw materials uses the drift of 25mm with the pressure tabletting of 60KN on tablet machine, is pressed into the tablet of 4 grams, uses pure aluminum foil bag or high-barrier anti-rot plastic bag packing.
1 gram of tablet is dropped in 2 liters of tap waters, and after 20 minutes, sampling detection aqueous solution of chlorine dioxide concentration is 46.33mg/L, and chlorine dioxide productive rate is 74%, and solution pH value is 6.7.
In temperature, be more than or equal to 54 degrees Celsius, relative humidity is greater than in 75% calorstat, and packaged titanium dioxide chlorine tablets are placed 14 days, and chlorine dioxide content rate of descent is 4.3%.
Embodiment 3
The tablet of preparing 4 grammes per square metres with following formula;
| Material name (kilogram) | Proportioning raw materials |
| Sodium chlorite (80% content) | 6 |
| Sodium dichloro cyanurate | 3 |
| Magnesium sulfate | 3 |
| Sodium chloride | 32 |
| Aluminum chloride | 4 |
| Polyvinylpyrrolidone | 2.5 |
| Citric acid | 40 |
| Sodium bicarbonate | 5 |
| Western pyrrole chloramines | 0.5 |
| Sodium peroxydisulfate | 3 |
Described in formula material is pressed to enforcement 1 and implemented 2, preparation method is made, and obtains after tablet combination raw materials, at tablet machine, uses the drift of 20mm with 60KN pressure tabletting, is pressed into the tablet of 4 gram weight, and use pure aluminum foil bag or high-barrier anti-rot plastic bag are packed.
4 grams of tablets are dropped in 4 premium on currency, and after 20 minutes, the concentration of sampling detection aqueous solution of chlorine dioxide is 3.248mg/L, and chlorine dioxide chemical yield is 67.52%, and solution pH value is 6.2.
In temperature, be more than or equal to 54 degrees Celsius, relative humidity is greater than in 75% calorstat, and packaged titanium dioxide chlorine tablets are placed 14 days, and chlorine dioxide content rate of descent is 3.2%.
Embodiment 4 (comparative example)
The tablet of preparing 1 gram weight with following formula A, formula B
| Material name (kilogram) | Proportioning raw materials A | Proportioning raw materials B |
| Sodium chlorite (80% content) | 12 | 12 |
| Sodium dichloro cyanurate | 6 | 6 |
| Magnesium sulfate | 3 | 5 |
| Sodium chloride | 31 | 15 |
| Aluminum chloride | ? | 12 |
| PVP/VA64 | 2.5 | 2.5 |
| Citric acid | 40 | 30 |
| Sodium bicarbonate | 5 | 3 |
| Western pyrrole chloramines | 0.5 | 0.5 |
| Sodium peroxydisulfate | ? | 14 |
The raw material of formula A, formula B is implemented according to the technical process described in embodiment 1, embodiment 2, obtained on tablet machine, using the drift of diameter 12mm with 25KN pressure tabletting after combination raw materials, be pressed into the tablet of 1 gram of weight.Respectively tablet is dropped in 1 liter of tap water, after 15 minutes, sampling detects.In temperature, be greater than 54 degrees Celsius of relative humiditys and be greater than in 75% climatic chamber, packaged medicine is placed 14 days, detect chlorine dioxide content rate of descent.Result is as follows;
| Index | Formula A | Formula B |
| Chlorine dioxide concentration, mg/L | 4.7 | 6.6 |
| The pH value of solution | 5.5 | 7.0 |
| Chemical yield: % | 58 | 69 |
| Content rate of descent: % | 3.5 | 3.7 |
By add activating catalyst aluminum chloride, sodium peroxydisulfate in combination formula, than independent use citric acid, further improved chlorine dioxide productive rate, chlorine dioxide chemical yield has improved 11%.Make the pH value of the ClO 2 solution that finally obtains bring up to 7.0 by 5.5 simultaneously, reach neutral, reduced corrosivity, zest to sterilization objects.
Embodiment 5
The tablet of preparing respectively 2 gram weight with following formula.Wherein A is not containing western pyrrole chloramines, and B contains western pyrrole chloramines.
| Material name (kilogram) | A tablet formulation | B tablet formulation |
| Sodium chlorite (80% content) | 24 | 24 |
| Sodium dichloro cyanurate | 12 | 12 |
| Magnesium sulfate | 5 | 5 |
| Sodium chloride | 8.5 | 8.5 |
| Aluminum chloride | 7 | 7 |
| PVP/VA64 | 2.5 | 2.5 |
| Citric acid | 22 | 22 |
| Sodium bicarbonate | 5 | 4.5 |
| Western pyrrole chloramines | ? | 0.5 |
| Sodium peroxydisulfate | 14 | 14 |
According to the technical process described in embodiment 1, embodiment 2, process, obtain after combination raw materials, on tablet machine, use the drift of diameter 12mm with 25kN pressure tabletting.Respectively 2 grams of tablets are dropped in quantitative tap water, sampling detects chlorine dioxide concentration in solution, the two no significant difference.
Get respectively quantitative A, B tablet drops in quantitative tap water, obtains the chlorine dioxide disinfection liquid of concentration known, function test carries out disinfection.Result is as follows;
Escherichia coli suspension is quantitatively killed test;
Conclusion (of pressure testing);
It is 50mg/L that the chlorine dioxide disinfection liquid of A tablet formulation is killed colibacillary minimum effective dose
It is that 40mg/L staphylococcus aureus suspension is quantitatively killed test that the chlorine dioxide disinfection liquid of B tablet formulation is killed colibacillary minimal effective concentration
Conclusion (of pressure testing):
The minimum effective dose that the chlorine dioxide disinfection liquid of A tablet formulation is killed staphylococcus aureus is 50mg/L
The minimal effective concentration that the chlorine dioxide disinfection liquid of B tablet formulation is killed staphylococcus aureus is 40mg/L
Bacillus subtilis black variety gemma suspension is quantitatively killed test
Conclusion (of pressure testing);
The minimum effective dose that the chlorine dioxide disinfection liquid of A tablet formulation is killed bacillus subtilis black variety gemma is 300mg/L.
The minimum effective dose that the chlorine dioxide disinfection liquid of B tablet formulation is killed bacillus subtilis black variety gemma is 250mg/L.
Practical application test;
B tablet, has done bottle rinse test in medicated beer company limited of Jing Zhou Baolong with B tablet, and its result is as follows;
Pack respectively three beer bottles into 10mL containing bacterium solution, then each 40mL of disinfection by chlorine dioxide solution of the 2.0mg/L of preparation, 6.6mg/L, 15.5mg/L concentration is poured in beer bottle, after 15 minutes, carry out antibacterial culturing detection, cultivating testing result after 48h hour shows, when 6.6mg/L concentration, antibacterial all can be killed, during 2.0mg.L concentration, bactericidal effect is good.
A tablet, pack respectively three beer bottles into 10mL containing bacterium solution, then each 40mL of disinfection by chlorine dioxide solution of the 2.0mg/L of preparation, 6.6mg/L, 15.5mg/L concentration is poured in beer bottle, after 15 minutes, carry out antibacterial culturing detection, cultivating testing result after 48h hour shows, when 15.5mg/L concentration, antibacterial all can be killed, during 6.6mg.L concentration, bactericidal effect is good.
Result surface is bright, adds western pyrrole chloramines surfactant to compare with not adding surfactant product in chlorine dioxide effervescent tablet formula, under same experimental conditions, can obviously improve the disinfection efficacy of product.Can provide following partial interpretation; Western pyrrole chloramines can reduce the surface tension of formed aqueous solution of chlorine dioxide, improves the permeability of ClO 2 solution to body surface, has strengthened the disinfection efficacy of aqueous solution of chlorine dioxide.
Claims (12)
1. kill a chlorine dioxide effervescent tablet for beriberi antibacterial, fungus, it comprises following component by weight;
2. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described described chlorite is a kind of of chlorous alkali metal or alkali salt.
3. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described solid acid is citric acid or tartaric acid.
4. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described activator is a kind of of sodium dichloro cyanurate or sodium trichloro-isocyanurate.
5. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described catalyst is aluminum chloride or sodium peroxydisulfate.
6. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described desiccant is a kind of of calcium chloride, magnesium sulfate or sodium sulfate.
7. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described surfactant is cationic surfactant.
8. according to claim 7 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described cationic surfactant is western pyrrole chloramines.
9. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described binding agent is a kind of of polyvinylpyrrolidone, sodium carboxymethyl cellulose, copolyvidone or low-substituted hydroxypropyl cellulose.
10. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described releasing agent is a kind of of microcrystalline Cellulose, boric acid, sodium chloride or micropowder silica gel.
11. according to claim 1 chlorine dioxide effervescent tablet of killing beriberi antibacterial, fungus, it is characterized in that: described effervescent is a kind of carbonate of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate or magnesium carbonate.
12. 1 kinds for killing the antibacterial of beriberi, the preparation method of the chlorine dioxide effervescent tablet of fungus, it comprises the following steps;
1), first described each component raw material is put into respectively to exsiccator, be warming up to 80～90 ℃ dry, until water content, reach 1% discharging when following, be respectively charged in moisture tight container standby;
2), by chlorite, solid acid, activator, catalyst, binding agent, effervescent, releasing agent, surfactant, in pulverizer and concussion sieve, pulverize respectively, sieve; Sodium chlorite 20～60 orders, solid acid 20～60 orders, activator 80～100 orders, catalyst 30～40 orders, desiccant 80～100 orders, surfactant 100～200 orders, effervescent 30～60 orders, releasing agent 100～200 orders, binding agent 80-100 orders; The raw material of pulverizing, the granularity of sieving is qualified is respectively charged in moisture tight container standby;
3), in blender, add sodium chlorite, after adding again effervescent, surfactant and desiccant, releasing agent fully to mix, add again activator, catalyst, binding agent, after finally adding solid acid to mix, discharging is pressed into effervescent tablet on tablet machine, and tabletting operating environment relative humidity is controlled at below 40%;
4), with material or the container of high-barrier, lucifuge, effervescent tablet is packed.
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| CN110150315A (en) * | 2019-05-17 | 2019-08-23 | 四川蓝洁绿源环保科技有限公司 | A kind of solid high-pure chlorinedioxide releasing agent |
| CN111480657A (en) * | 2020-05-20 | 2020-08-04 | 陈冠荣 | Stable composite chlorine dioxide solid lozenge and preparation method thereof |
| CN111603425A (en) * | 2020-06-02 | 2020-09-01 | 意润健康产业（广州）有限公司 | Multifunctional effervescent tablet of skin disinfection cleaning solution and preparation method thereof |
| CN115777723A (en) * | 2023-02-07 | 2023-03-14 | 山东华实药业有限公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
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