CN115777723A - Instant chlorine dioxide effervescent tablet and preparation method thereof - Google Patents
Instant chlorine dioxide effervescent tablet and preparation method thereof Download PDFInfo
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- CN115777723A CN115777723A CN202310075739.8A CN202310075739A CN115777723A CN 115777723 A CN115777723 A CN 115777723A CN 202310075739 A CN202310075739 A CN 202310075739A CN 115777723 A CN115777723 A CN 115777723A
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Abstract
The invention discloses an instant chlorine dioxide effervescent tablet and a preparation method thereof, wherein the instant chlorine dioxide effervescent tablet comprises the following components in parts by weight: 10-40 parts of sodium chlorite, 3-8 parts of composite adhesive, 3-10 parts of effervescent disintegrant, 15-60 parts of acidifier, 5-20 parts of accelerant, 2-5 parts of water-soluble lubricant and the balance of water; the invention belongs to the technical field of effervescent tablets, and particularly relates to an instant chlorine dioxide effervescent tablet and a preparation method thereof; the invention adopts a new adhesive and effervescent tablet disintegrating agent, improves the adhesion degree of each material, plays the roles of wrapping all components and completely isolating and preventing reaction, accelerates the disintegration speed of the effervescent tablet, solves the problems of low tabletting success rate and low disintegration efficiency of the chlorine dioxide effervescent tablet on the market, effectively improves the tabletting success rate, the disintegration efficiency and the chlorine dioxide conversion rate of the chlorine dioxide effervescent tablet, and quickly and completely dissolves in water to generate chlorine dioxide.
Description
Technical Field
The invention belongs to the technical field of effervescent tablets, and particularly relates to an instant chlorine dioxide effervescent tablet and a preparation method thereof.
Background
Chlorine dioxide is an internationally recognized fourth-generation disinfectant, has greater advantages in disinfection effect and environmental protection performance compared with the current commonly used disinfectant, can kill bacterial propagules, fungi, spores, even viruses and pathogenic protozoa, has rapid action, no three-cause effect (carcinogenesis, teratogenesis and mutation), and no residue after the action; at present, dosage forms of the chlorine dioxide disinfectant mainly comprise liquid dosage forms and solid dosage forms, the solid dosage forms comprise binary packages and unitary packages, the volume of a chlorine dioxide liquid preparation product is large, the transportation is inconvenient, the binary packages of the solid dosage forms also have the problems of inconvenient use and the like, and the conventional method for preparing chlorine dioxide is a chlorine dioxide effervescent tablet.
The effervescent tablet is a tablet consisting of an acid agent and an alkaline agent capable of generating carbon dioxide, and when encountering water, the effervescent tablet generates a neutralization reaction to release carbon dioxide gas, so that the tablet is a solid preparation which can be quickly disintegrated and dissolved.
Disclosure of Invention
Aiming at the situation and overcoming the defects of the prior art, the invention provides an instant chlorine dioxide effervescent tablet and a preparation method thereof, wherein a novel composite adhesive and an effervescent disintegrant are adopted, and the addition of the composite adhesive weakens the hardness of the effervescent tablet, so that the effervescent tablet is not easy to crack in the tabletting process, and simultaneously, the instant chlorine dioxide effervescent tablet can play a role in completely isolating and preventing reaction and accelerating the disintegration of the effervescent tablet; the effervescent disintegrant is added, so that the effervescent tablet is disintegrated immediately when meeting water, the acid and the alkali are ionized under the action of the water and generate double decomposition reaction to generate a large amount of carbon dioxide, the effervescent tablet is rapidly disintegrated and melted, and the complete disintegration of the effervescent tablet improves the conversion rate of chlorine dioxide; the invention solves the problems of low tabletting success rate and low disintegration efficiency of the chlorine dioxide effervescent tablets in the market, effectively improves the tabletting success rate, the disintegration efficiency and the chlorine dioxide conversion rate of the chlorine dioxide effervescent tablets, and can be quickly and completely dissolved in water to generate chlorine dioxide.
The technical scheme adopted by the invention is as follows: the invention provides an instant chlorine dioxide effervescent tablet and a preparation method thereof, wherein the instant chlorine dioxide effervescent tablet comprises the following components in parts by weight: 10-40 parts of sodium chlorite, 3-8 parts of composite adhesive, 3-10 parts of effervescent disintegrant, 15-60 parts of acidifier, 5-20 parts of accelerant, 2-5 parts of water-soluble lubricant and the balance of water; the composite adhesive comprises the following components in parts by weight: 2-8 parts of bipyridyl ionic monomer, 3-6 parts of methacrylated gelatin, 3-8 parts of povidone, 2-4 parts of hydroxypropyl methylcellulose and 2-4 parts of copovidone.
Further, the preparation method of the bipyridyl ion monomer comprises the following steps: adding 2,2 '-bipyridyl-4, 4' -dicarboxylic acid and 1, 2-dibromoethane into a 50mL polytetrafluoroethylene lining autoclave, stirring for 15-30 minutes at room temperature, then placing into a constant-temperature oven with the temperature of 100-130 ℃ for reaction for 24-48 hours, after the reaction is finished, filtering, washing with ethyl acetate for 3 times, and placing into a vacuum oven with the temperature of 80 ℃ for drying for 12 hours to obtain the bipyridyl ionic monomer.
Preferably, the molar ratio of the 2,2 '-bipyridine-4, 4' -dicarboxylic acid to 1, 2-dibromoethane is 1.7-1.
Preferably, the effervescent disintegrant comprises the following components in parts by weight: 2-4 parts of sodium starch glycolate, 3-6 parts of citric acid, 4-6 parts of tartaric acid and 2-8 parts of sodium bicarbonate.
Further, the acidulant comprises one or more of citric acid, malic acid, tartaric acid and sorbic acid in combination.
Further, the accelerator is one of sodium dichloroisocyanurate and trichloroisocyanuric acid; the water-soluble lubricant comprises one or more of polyethylene glycol, polyoxyethylene lauryl alcohol ether, sodium acetate and sodium benzoate.
The invention also provides a preparation method of the instant chlorine dioxide effervescent tablet, which comprises the following steps:
(1) Adding the composite adhesive into water, and stirring at room temperature at 500-800 rpm for 15-30 minutes to obtain a material A;
(2) Sieving sodium chlorite and effervescent tablet disintegrating agent through a sieve of 50-80 meshes, putting into a container, stirring for 5 minutes, and uniformly mixing to form a material B for later use;
(3) Then stirring the acidifying agent, the accelerator, the water-soluble lubricant, the material A and the material B for 10-20 minutes, and uniformly mixing to obtain a mixture A;
(4) And (3) pressing the mixture A into tablets on a tablet press under the environment that the temperature is 22-28 ℃ and the relative humidity is 25% -55%.
The beneficial effects obtained by the invention are as follows:
(1) The invention uses a new composite adhesive, wherein, the addition of bipyridyl ion monomer and methacrylated gelatin improves the adhesive degree of each material, improves the success rate of tabletting in the tabletting process, and can wrap all components and completely isolate and prevent the reaction, and the appropriate amount of the composite adhesive can ensure that the chlorine dioxide effervescent tablet has moderate hardness and short disintegration time limit;
(2) According to the effervescent tablet, the sodium starch glycolate, the citric acid, the tartaric acid and the sodium bicarbonate are used as the effervescent disintegrant, and after the sodium starch glycolate, the citric acid, the tartaric acid and the sodium bicarbonate are mixed with water, the components react rapidly to generate a large amount of carbon dioxide, so that the effervescent tablet is rapidly disintegrated and melted, and the conversion rate of chlorine dioxide is improved due to the complete disintegration of the effervescent tablet;
(3) The promoter used in the invention has the function of promoting the generation of catalytic chlorine dioxide, and can obtain high-content and high-purity chlorine dioxide;
(4) The water-soluble lubricant used in the invention can smoothly discharge and discharge tablets in the tabletting process, can reduce the sticking and the friction force between granules and between tablets and film holes, and can increase the fluidity of the granules;
(5) The preparation process is simple, the preparation cost is low, the chlorine dioxide effervescent tablet is convenient to use, and chlorine dioxide solution with any concentration can be obtained only by dissolving the chlorine dioxide effervescent tablet in quantitative water.
Drawings
FIG. 1 is a graph showing the effect of example 1, comparative example 2 and comparative example 3 on hardness and disintegration time;
FIG. 2 is a graph of the effect of effervescent tablet disintegrant on chlorine dioxide conversion;
FIG. 3 is an SEM photograph of comparative example 3 and example 1;
FIG. 4 is an SEM image before and after inactivation of E.coli.
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the examples of the present invention, unless otherwise specified, all the conventional commercially available materials or conventional processing techniques in the art are indicated.
The 2,2 '-bipyridine-4, 4' -dicarboxylic acid (96%) and 1, 2-dibromoethane (99%) used in the present invention were purchased from alatin; methacrylated gelatin (97%) was purchased from lexan reagent; sodium starch glycolate (99%) was purchased from yagi biotechnology limited, shanghai.
Example 1
The invention provides an instant chlorine dioxide effervescent tablet
The instant chlorine dioxide effervescent tablet comprises the following components in parts by weight: 30 parts of sodium chlorite, 5 parts of composite adhesive, 8 parts of effervescent disintegrant, 45 parts of acidifier, 15 parts of accelerant, 5 parts of water-soluble lubricant and the balance of water; the composite adhesive comprises the following components in parts by weight: 5 parts of bipyridine ionic monomer, 4 parts of methacrylated gelatin, 6 parts of povidone, 3 parts of hydroxypropyl methylcellulose and 3 parts of copovidone.
Further, the preparation method of the bipyridyl ion monomer comprises the following steps: 1.1g of 2,2 '-bipyridine-4, 4' -dicarboxylic acid and 1.7g of 1, 2-dibromoethane are added into a 50mL polytetrafluoroethylene-lined autoclave, stirred at room temperature for 20 minutes, placed into a constant-temperature oven at 120 ℃ for reaction for 36 hours, filtered after the reaction is finished, washed with ethyl acetate for 3 times, and placed into a vacuum oven at 80 ℃ for drying for 12 hours, so that the bipyridine ionic monomer is obtained.
Wherein the effervescent disintegrant comprises the following components in parts by weight: 3 parts of sodium starch glycolate, 5 parts of citric acid, 5 parts of tartaric acid and 5 parts of sodium bicarbonate.
Wherein the acidulant is citric acid; the accelerant is trichloroisocyanuric acid; the water-soluble lubricant is polyethylene glycol.
The invention also provides a preparation method of the instant chlorine dioxide effervescent tablet, which comprises the following steps:
(1) Adding 5 parts of the composite adhesive into water, and stirring at 600 revolutions per minute for 20 minutes at room temperature to obtain a material A;
(2) Sieving 30 parts of sodium chlorite and 8 parts of effervescent tablet disintegrating agent by a 60-mesh screen, putting into a container, stirring for 5 minutes, and uniformly mixing to form a material B for later use;
(3) Then, 45 parts of an acidifying agent, 15 parts of an accelerant, 5 parts of a water-soluble lubricant, the material A and the material B are stirred for 15 minutes and are uniformly mixed to obtain a mixture A;
(4) And pressing the mixture A on a tablet press to form the chlorine dioxide effervescent tablet in an environment with the temperature of 25 ℃ and the relative humidity of 40%.
Example 2
The invention provides an instant chlorine dioxide effervescent tablet
The instant chlorine dioxide effervescent tablet comprises the following components in parts by weight: 10 parts of sodium chlorite, 3 parts of composite adhesive, 3 parts of effervescent disintegrant, 15 parts of acidifier, 5 parts of accelerant, 2 parts of water-soluble lubricant and the balance of water; the composite adhesive comprises the following components in parts by weight: 2 parts of bipyridyl ionic monomer, 3 parts of methacrylated gelatin, 3 parts of povidone, 2 parts of hydroxypropyl methylcellulose and 2 parts of copovidone.
Further, the preparation method of the bipyridyl ion monomer comprises the following steps: adding 1.1g of 2,2 '-bipyridyl-4, 4' -dicarboxylic acid and 1.4g of 1, 2-dibromoethane into a 50mL polytetrafluoroethylene-lined autoclave, stirring for 15 minutes at room temperature, then placing the autoclave into a constant-temperature oven at 100 ℃ for reaction for 24 hours, filtering after the reaction is finished, washing the autoclave for 3 times by using ethyl acetate, and placing the autoclave into a vacuum oven at 80 ℃ for drying for 12 hours to obtain the bipyridyl ionic monomer.
Wherein the effervescent disintegrant comprises the following components in parts by weight: 2 parts of sodium starch glycolate, 3 parts of citric acid, 4 parts of tartaric acid and 2 parts of sodium bicarbonate.
Wherein the acidulant is malic acid; the accelerant is trichloroisocyanuric acid; the water-soluble lubricant is polyoxyethylene lauryl alcohol ether.
In addition, the invention also provides a preparation method of the instant chlorine dioxide effervescent tablet, which is implemented by referring to the embodiment 1.
Example 3
The invention provides an instant chlorine dioxide effervescent tablet
The instant chlorine dioxide effervescent tablet comprises the following components in parts by weight: 35 parts of sodium chlorite, 6 parts of composite adhesive, 7 parts of effervescent disintegrant, 52 parts of acidifier, 13 parts of accelerant, 3 parts of water-soluble lubricant and the balance of water; the composite adhesive comprises the following components in parts by weight: 4 parts of bipyridyl ionic monomer, 5 parts of methacrylated gelatin, 6 parts of povidone, 3 parts of hydroxypropyl methylcellulose and 3 parts of copovidone.
Further, the preparation method of the bipyridyl ion monomer comprises the following steps: 1.1g of 2,2 '-bipyridine-4, 4' -dicarboxylic acid and 1.6g of 1, 2-dibromoethane are added into a 50mL polytetrafluoroethylene-lined autoclave, stirred at room temperature for 20 minutes, then placed into a constant-temperature oven at 120 ℃ for reaction for 30 hours, and after the reaction is finished, the mixture is filtered, washed with ethyl acetate for 3 times, and then placed into a vacuum oven at 80 ℃ for drying for 12 hours, so that the bipyridine ionic monomer is obtained.
Wherein the effervescent disintegrant comprises the following components in parts by weight: 3 parts of sodium starch glycolate, 4 parts of citric acid, 5 parts of tartaric acid and 7 parts of sodium bicarbonate.
Wherein the acidulant is sorbic acid; the accelerant is trichloroisocyanuric acid; the water-soluble lubricant is sodium acetate.
In addition, the invention also provides a preparation method of the instant chlorine dioxide effervescent tablet, which is implemented by referring to the embodiment 1.
Example 4
The invention provides an instant chlorine dioxide effervescent tablet
The instant chlorine dioxide effervescent tablet comprises the following components in parts by weight: 40 parts of sodium chlorite, 8 parts of composite adhesive, 10 parts of effervescent disintegrant, 60 parts of acidifier, 20 parts of accelerant, 5 parts of water-soluble lubricant and the balance of water; the composite adhesive comprises the following components in parts by weight: 8 parts of bipyridyl ionic monomer, 6 parts of methacrylated gelatin, 8 parts of povidone, 4 parts of hydroxypropyl methylcellulose and 4 parts of copovidone.
Further, the preparation method of the bipyridyl ionic monomer comprises the following steps: adding 1.1g of 2,2 '-bipyridyl-4, 4' -dicarboxylic acid and 1.9g of 1, 2-dibromoethane into a 50mL polytetrafluoroethylene-lined autoclave, stirring for 30 minutes at room temperature, then placing the mixture into a constant-temperature oven at 130 ℃ for reaction for 48 hours, filtering after the reaction is finished, washing the mixture for 3 times by using ethyl acetate, and placing the mixture into a vacuum oven at 80 ℃ for drying for 12 hours to obtain the bipyridyl ionic monomer.
Wherein the effervescent disintegrant comprises the following components in parts by weight: 4 parts of sodium starch glycolate, 6 parts of citric acid, 6 parts of tartaric acid and 8 parts of sodium bicarbonate.
Wherein the acidulant is tartaric acid; the accelerant is sodium dichloroisocyanurate; the water-soluble lubricant is sodium benzoate.
In addition, the invention also provides a preparation method of the instant chlorine dioxide effervescent tablet, which is implemented by referring to the embodiment 1.
Comparative example 1
This comparative example provides an instant chlorine dioxide effervescent, which differs from example 1 only in that the components in the composite binder do not contain bipyridyl ion monomer, and the remaining components, component content are the same as in example 1.
Comparative example 2
The comparative example provides an instant chlorine dioxide effervescent tablet which is different from the embodiment 1 only in that the component in the composite binder does not contain the methacrylated gelatin, and the rest components and the content of the components are the same as the embodiment 1.
Comparative example 3
The comparative example provides an instant chlorine dioxide effervescent tablet, which is different from the embodiment 1 only in that the components in the composite binder do not contain bipyridyl ion monomer and methacrylated gelatin, and the rest components and the content of the components are the same as the embodiment 1.
Comparative example 4
This comparative example provides an instant chlorine dioxide effervescent tablet which differs from example 1 only in that it does not contain an effervescent tablet disintegrant and the remaining components, component contents, are the same as in example 1.
Experimental example 1
The composite adhesive and the effervescent tablet disintegrating agent are used as factors for investigation, a plurality of instant chlorine dioxide effervescent tablets are prepared from example 1, example 2, example 3, example 4, comparative example 1, comparative example 2, comparative example 3 and comparative example 4, and the influence of the addition of the composite adhesive and the effervescent tablet disintegrating agent on the hardness, disintegration speed and chlorine dioxide conversion rate of the chlorine dioxide effervescent tablet is examined by using the hardness, disintegration time limit and chlorine dioxide conversion rate of the chlorine dioxide effervescent tablet as evaluation indexes.
As a result, as shown in fig. 1, fig. 2 and fig. 3, the hardness and disintegration time of example 1 were superior to those of other samples, the hardness and disintegration time of comparative example 1 containing no bipyridyl ion monomer were slightly superior to those of comparative example 2 containing no methacrylated gelatin, and the hardness of comparative example 3 containing no bipyridyl ion monomer and methacrylated gelatin was too large, and thus, cracks were easily generated during tabletting, and each material could not be completely encapsulated, and the function of completely blocking the reaction could not be fully exerted, resulting in delayed disintegration; compared with the comparative example 3 and the example 1 which do not contain the bipyridyl ion monomer and the methacrylated gelatin, the bipyridyl ion monomer and the methacrylated gelatin are added in the example 1, so that gaps among particles are effectively filled and leveled, and the surface structure is uniform; comparative example 4, which did not contain effervescent tablet disintegrant, had the lowest chlorine dioxide conversion.
Experimental example 2
At present, a water dispenser has a serious microbial pollution problem in use, according to a report issued by a national environmental monitoring department, a large amount of bacteria and fungi are bred even a biofilm is formed when the traditional water dispenser is not cleaned for more than 3 months, symptoms such as gastrointestinal discomfort, abdominal pain, diarrhea, urinary tract infection and the like can be caused slightly, and the serious water dispenser can become a root cause of epidemic outbreak of digestive tract infectious diseases. Therefore, the regular cleaning and disinfection of the water dispenser is particularly important for guaranteeing the sanitation and safety of drinking water. In order to test the disinfection effect of the instant chlorine dioxide effervescent tablet prepared by the scheme of the embodiment of the invention, the killing effect of the instant chlorine dioxide effervescent tablet prepared in the embodiment 1 on escherichia coli is tested.
The disinfection method of the water dispenser comprises the following steps: one instant chlorine dioxide disinfectant effervescent tablet prepared in example 1 was dissolved in 500mL of water, poured into a drinking machine through a water filling port of the drinking machine, and added with water to the upper edge of the water filling port (total volume about 2.5L). The disinfectant is completely discharged from the front water outlet and the rear blow-off pipe of the water dispenser, mixed evenly and poured into the water dispenser again for formal disinfection, and the disinfectant is completely discharged through the front and rear water outlets after acting for 2 minutes.
The water dispenser disinfection experiment: the prepared escherichia coli bacterial suspension is uniformly smeared on sampling positions of front and rear water outlets of different parts (contacting with the inner wall of the aperture, the diameter part of the central hole and the bottom of the central hole of the water injection barrel) of a water injection port of the water dispenser by using a cotton swab, and the test is carried out after the escherichia coli bacterial suspension is naturally dried. Sterilizing the water dispenser, wetting a sterile cotton swab in a test tube containing 5mL of neutralizer sampling liquid after the sterilization is finished, smearing and sampling a sterilization area, and reciprocating 8 times horizontally and vertically. And shearing a sampling end into a sampling liquid test tube in an aseptic operation mode after sampling, respectively sucking 1.0mL after fully shaking, inoculating a plate, pouring TSA agar, condensing, then placing in an incubator at 37 ℃ for culturing for 48 hours, and counting the number of viable bacteria. And 3 infected samples which are not soaked in the disinfectant are taken as a positive control group.
TABLE 1 Disinfection of different parts of a water dispenser by an instant chlorine dioxide Disinfection effervescent tablet
Note: the log value range of the number of the positive control bacteria is 7.30-8.10.
As shown in figure 4, after the instant chlorine dioxide effervescent tablet provided by the invention is used for disinfecting a water dispenser, escherichia coli is inactivated, and after 2 minutes of action, the escherichia coli polluted at the inner wall, the bottom, the aperture, the front water outlet, the rear water outlet and the like of a water filling port of the water dispenser can be reduced to 0 cfu/mL, which indicates that the instant chlorine dioxide effervescent tablet provided by the invention has a good effect of killing the escherichia coli.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The present invention and its embodiments have been described above, and the description is not intended to be limiting, and the drawings are only one embodiment of the present invention, and the actual structure is not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (7)
1. The instant chlorine dioxide effervescent tablet is characterized by comprising the following components in parts by weight: 10-40 parts of sodium chlorite, 3-8 parts of composite adhesive, 3-10 parts of effervescent disintegrant, 15-60 parts of acidifier, 5-20 parts of accelerant, 2-5 parts of water-soluble lubricant and the balance of water; the composite adhesive comprises the following components in parts by weight: 2-8 parts of bipyridyl ionic monomer, 3-6 parts of methacrylated gelatin, 3-8 parts of povidone, 2-4 parts of hydroxypropyl methylcellulose and 2-4 parts of copovidone.
2. The instant effervescent chlorine dioxide tablet of claim 1, wherein: the preparation method of the bipyridyl ionic monomer comprises the following steps: adding 2,2 '-bipyridyl-4, 4' -dicarboxylic acid and 1, 2-dibromoethane into a 50mL polytetrafluoroethylene lining autoclave, stirring for 15-30 minutes at room temperature, then placing into a constant-temperature oven with the temperature of 100-130 ℃ for reaction for 24-48 hours, after the reaction is finished, filtering, washing with ethyl acetate for 3 times, and placing into a vacuum oven with the temperature of 80 ℃ for drying for 12 hours to obtain the bipyridyl ionic monomer.
3. An instant effervescent chlorine dioxide tablet according to claim 2, wherein: the molar ratio of the 2,2 '-bipyridine-4, 4' -dicarboxylic acid to 1, 2-dibromoethane is 1.7-1.
4. An instant effervescent chlorine dioxide tablet according to claim 3, wherein: the effervescent disintegrant comprises the following components in parts by weight: 2-4 parts of sodium starch glycolate, 3-6 parts of citric acid, 4-6 parts of tartaric acid and 2-8 parts of sodium bicarbonate.
5. The instant chlorine dioxide effervescent tablet of claim 4, wherein: the acidulant comprises one or more of citric acid, malic acid, tartaric acid and sorbic acid.
6. An instant effervescent chlorine dioxide tablet according to claim 5, wherein: the accelerant is one of sodium dichloroisocyanurate and trichloroisocyanuric acid; the water-soluble lubricant comprises one or a combination of polyethylene glycol, polyoxyethylene lauryl ether, sodium acetate and sodium benzoate.
7. A method for preparing instant effervescent chlorine dioxide tablet as claimed in claim 6, characterized in that it comprises the following steps:
(1) Adding the composite adhesive into water, and stirring at room temperature at 500-800 rpm for 15-30 minutes to obtain a material A;
(2) Sieving sodium chlorite and effervescent tablet disintegrating agent through a sieve of 50-80 meshes, putting into a container, stirring for 5 minutes, and uniformly mixing to form a material B for later use;
(3) Then stirring the acidifying agent, the accelerator, the water-soluble lubricant, the material A and the material B for 10-20 minutes, and uniformly mixing to obtain a mixture A;
(4) And pressing the mixture A into tablets on a tablet press under the environment that the temperature is 22-28 ℃ and the relative humidity is 25% -55%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116019125A (en) * | 2023-03-29 | 2023-04-28 | 山东华实药业有限公司 | Chlorine dioxide slow-release gel and preparation method thereof |
| CN116548467A (en) * | 2023-07-11 | 2023-08-08 | 山东华实药业有限公司 | Chlorine dioxide disinfectant and its production process and application |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245361B1 (en) * | 1995-08-15 | 2001-06-12 | S. C. Johnson Commercial Markets, Inc. | Tuberculocidal synergistic disinfectant compositions and methods of disinfecting |
| CN101228868A (en) * | 2008-02-27 | 2008-07-30 | 河北科技大学 | Unitary solid chlorine dioxide effervescent tablet and preparation method thereof |
| CN101703071A (en) * | 2009-11-13 | 2010-05-12 | 北京欧凯纳斯科技有限公司 | Disinfectant composition containing molecular-state chlorine dioxide and applications thereof |
| CN102246819A (en) * | 2011-05-19 | 2011-11-23 | 成都阳光生物科技有限责任公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
| CN102246752A (en) * | 2011-05-13 | 2011-11-23 | 石家庄国大工业有限公司 | Effervescent disinfection tablet and preparation method thereof |
| US20120015948A1 (en) * | 2009-03-31 | 2012-01-19 | Ulick Stafford | Tablet composition |
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| WO2021211411A1 (en) * | 2020-04-13 | 2021-10-21 | The University Of North Carolina At Chapel Hill | Disinfectant compositions and methods of making and using the same |
| CN115517266A (en) * | 2022-11-08 | 2022-12-27 | 安徽逸天科技有限公司 | Chlorine dioxide effervescent pellet |
-
2023
- 2023-02-07 CN CN202310075739.8A patent/CN115777723B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245361B1 (en) * | 1995-08-15 | 2001-06-12 | S. C. Johnson Commercial Markets, Inc. | Tuberculocidal synergistic disinfectant compositions and methods of disinfecting |
| CN101228868A (en) * | 2008-02-27 | 2008-07-30 | 河北科技大学 | Unitary solid chlorine dioxide effervescent tablet and preparation method thereof |
| US20120015948A1 (en) * | 2009-03-31 | 2012-01-19 | Ulick Stafford | Tablet composition |
| CN101703071A (en) * | 2009-11-13 | 2010-05-12 | 北京欧凯纳斯科技有限公司 | Disinfectant composition containing molecular-state chlorine dioxide and applications thereof |
| CN102246752A (en) * | 2011-05-13 | 2011-11-23 | 石家庄国大工业有限公司 | Effervescent disinfection tablet and preparation method thereof |
| CN102246819A (en) * | 2011-05-19 | 2011-11-23 | 成都阳光生物科技有限责任公司 | Instant chlorine dioxide effervescent tablet and preparation method thereof |
| CN104138390A (en) * | 2014-06-11 | 2014-11-12 | 龚佳郎 | Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof |
| WO2021211411A1 (en) * | 2020-04-13 | 2021-10-21 | The University Of North Carolina At Chapel Hill | Disinfectant compositions and methods of making and using the same |
| CN115517266A (en) * | 2022-11-08 | 2022-12-27 | 安徽逸天科技有限公司 | Chlorine dioxide effervescent pellet |
Non-Patent Citations (1)
| Title |
|---|
| 张林霞 等: "一元固体二氧化氯泡腾片的工艺研究" * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116019125A (en) * | 2023-03-29 | 2023-04-28 | 山东华实药业有限公司 | Chlorine dioxide slow-release gel and preparation method thereof |
| CN116019125B (en) * | 2023-03-29 | 2023-05-23 | 山东华实药业有限公司 | Chlorine dioxide slow-release gel and preparation method thereof |
| CN116548467A (en) * | 2023-07-11 | 2023-08-08 | 山东华实药业有限公司 | Chlorine dioxide disinfectant and its production process and application |
| CN116548467B (en) * | 2023-07-11 | 2023-09-19 | 山东华实药业有限公司 | Chlorine dioxide disinfectant and its production process and application |
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| CN115777723B (en) | 2023-04-07 |
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