CN107616960B - Biological sterilization hand sanitizer and production process thereof - Google Patents
Biological sterilization hand sanitizer and production process thereof Download PDFInfo
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Abstract
The invention discloses a biological sterilization hand sanitizer and a production process thereof, aiming at the disadvantages and the defects of the traditional extraction technology, a new extraction technology is used for preparing a plant extract, and the extraction process is improved from the aspects of free radical removal, bacteriostasis effect and the like; the biological sterilization hand sanitizer contains various biological components, is mild in property, and can be used for sensitive skin; can effectively kill germs and protect skin. The production process comprises the following steps: s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a sieve of 10-50 meshes to obtain eucalyptus leaf powder; soaking folium Eucalypti Globueli powder in water at 25-55 deg.C for 3-5 hr, filtering, concentrating, centrifuging, and collecting supernatant to obtain folium Eucalypti Globueli extractive solution; s2, taking 2-5 parts by weight of eucalyptus leaf extract, 1.5-2.5 parts by weight of cocamidopropyl betaine, 1.5-2.5 parts by weight of glycerol, 0.02-0.08 part by weight of biological bactericide, 0.03-0.09 part by weight of vitamin A, 2-4 parts by weight of sodium chloride and 90-100 parts by weight of water, and uniformly stirring and mixing to obtain the compound.
Description
Technical Field
The invention relates to the technical field of hand sanitizer, in particular to a biological sterilization hand sanitizer and a production process thereof.
Background
In life and work, both hands can not be contacted with objects with microorganisms and even pathogenic microorganisms, so that the hands are infected with bacteria. The measures for preventing infection are firstly to avoid contacting with polluted articles, and secondly to form good personal hygiene habits to wash hands and disinfect the hands on duty, thereby avoiding the probability of spreading due to hand contact. At present, the hand sanitizer is accepted by more and more consumers as a daily washing product and is introduced into thousands of households. However, the types of the current detergents are also of the eight families, and various detergents mainly prepared from sodium lauryl sulfate, ammonium fatty alcohol sulfate, sodium dodecyl polyoxyethylene sulfate, sodium chloride, essence, pigment, water and the like are produced at the same time.
Therefore, some manufacturers can put the hand sanitizer on the market at a proper time and receive good comment. However, in use, most of the hand sanitizer has various components, and most of the components are chemical product compositions. People can enjoy sanitation and convenience, and worry about the problem of residual components of the hand sanitizer, so that the use crowd is very limited, and the popularization and the use of the products are not facilitated.
Therefore, the biological sterilization hand sanitizer is provided, aims to provide convenience for hand hygiene and cleaning, and meanwhile adopts green and environment-friendly plant components to improve the acceptance of people on products and relieve the psychological conflict of people on the products with the synthetic components. Therefore, the hand sanitizer can be widely used, and the occurrence of sanitary events is reduced.
Chinese patent (application number: 201410502142.8) discloses a hand sanitizer, which is prepared from the following components in parts by weight: 9-11 parts of lauryl alcohol polyoxyethylene ether sodium sulfate, 7-9 parts of sodium lauroyl sarcosinate, 3-4 parts of nonylphenol polyoxyethylene ether, 0.8-1.5 parts of sodium chloride, 2-3 parts of isopropyl myristate, 11-13 parts of indocalamus leaves, 9-11 parts of galangal, 6-8 parts of chitosan, 3-5 parts of clove oil, 2-4 parts of litsea cubeba oil, 5-7 parts of sodium alginate, 4-6 parts of jojoba oil and 110-130 parts of deionized water. The hand sanitizer has an outstanding sterilization effect, can effectively keep skin moist, and can nourish skin to make skin smoother after long-term use.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a biological sterilization hand sanitizer and a production process thereof.
The technical scheme is as follows:
a production process of a biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a sieve of 10-50 meshes to obtain eucalyptus leaf powder; soaking folium Eucalypti Globueli powder in solvent at 25-55 deg.C for 3-5 hr, filtering, concentrating, centrifuging, and collecting supernatant to obtain folium Eucalypti Globueli extractive solution;
s2, taking 2-5 parts by weight of eucalyptus leaf extract, 1.5-2.5 parts by weight of cocamidopropyl betaine, 1.5-2.5 parts by weight of glycerol, 0.02-0.08 part by weight of biological bactericide, 0.03-0.09 part by weight of vitamin A, 2-4 parts by weight of sodium chloride and 90-100 parts by weight of water, and uniformly mixing at the rotation speed of 300 plus materials at 500 rpm for 20-40 minutes.
As an improved technical scheme, the production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a sieve of 10-50 meshes to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into water, and soaking for 3-5 hours at the temperature of 25-55 ℃, wherein the mass ratio of the eucalyptus leaf powder to the water is 1: (10-30); soaking, transferring into plastic bag, removing bubbles, sealing, and extracting under ultrahigh pressure; filtering, concentrating, centrifuging, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 2-5 parts by weight of eucalyptus leaf extract, 1.5-2.5 parts by weight of cocamidopropyl betaine, 1.5-2.5 parts by weight of glycerol, 0.02-0.08 part by weight of biological bactericide, 0.03-0.09 part by weight of vitamin A, 2-4 parts by weight of sodium chloride and 90-100 parts by weight of water, and uniformly mixing at the rotation speed of 300 plus materials at 500 rpm for 20-40 minutes.
As another improved technical scheme, the production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a sieve of 10-50 meshes to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into a nonylphenol polyoxyethylene ether aqueous solution, and soaking for 3-5 hours at the temperature of 25-55 ℃, wherein the mass ratio of the eucalyptus leaf powder to the nonylphenol polyoxyethylene ether aqueous solution is 1: (10-30); soaking, transferring into plastic bag, removing bubbles, sealing, and extracting under ultrahigh pressure; filtering, concentrating, centrifuging, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 2-5 parts by weight of eucalyptus leaf extract, 1.5-2.5 parts by weight of cocamidopropyl betaine, 1.5-2.5 parts by weight of glycerol, 0.02-0.08 part by weight of biological bactericide, 0.03-0.09 part by weight of vitamin A, 2-4 parts by weight of sodium chloride and 90-100 parts by weight of water, and uniformly mixing at the rotation speed of 300 plus materials at 500 rpm for 20-40 minutes.
The pressure of the ultrahigh pressure extraction is 180-220MPa, and the time is 2-5 minutes.
The filter cloth for filtering is 250 meshes and 350 meshes.
The rotation speed of the centrifugation is 4000-6000 rpm, and the time is 10-20 minutes.
The vacuum degree of the concentration is 0.04-0.08MPa, the temperature is 55-65 ℃, and the time is 3-7 hours.
The mass fraction of the nonylphenol polyoxyethylene ether in the nonylphenol polyoxyethylene ether aqueous solution is 2-5%.
The biological bactericide is propolis flavone and/or apple polyphenol. In one embodiment of the present invention, the biological bactericide consists of 75-85 wt% of propolis flavone and 15-25 wt% of apple polyphenol.
A biological antibacterial hand sanitizer is prepared by the production process.
The technical effects are as follows:
the production process disclosed by the invention is used for preparing the plant extract by using a new extraction technology aiming at the disadvantages and the defects of the traditional extraction technology, and is improved in the aspects of removing free radicals, inhibiting bacteria and the like; the biological sterilization hand sanitizer contains various biological components, is mild in property, and can be used for sensitive skin; can effectively kill germs and protect skin.
Detailed Description
And (3) testing the antibacterial performance:
the beef extract peptone agar culture medium for bacterial culture has the following specific formula: 3.0g of beef extract, 10g of peptone, 5.0g of sodium chloride, 20g of agar and 1000mL of water are heated to melt, and the pH value is adjusted to 7.4-7.6. Subpackaging, and sterilizing under high pressure and moist heat (121 deg.C, 20min) for use.
Strain: staphylococcus aureus (Staphylococcus aureus), Escherichia coli (Escherichia coli).
Transferring all tested strains to corresponding test tube slant culture medium, and repeating the inoculation of each strain. The bacteria are cultured in a biochemical incubator at 37 ℃ for 24h, and the mould is cultured at 28 ℃ for 48 h. 2 of each strain was used for the experiment, and the rest was refrigerated for further use.
Selecting each colony, inoculating to a plate, culturing bacteria for 24 hr, eluting with sterile normal saline, and making into 10-containing bacteria7CFU/mL of bacterial suspension. The preparation method comprises the following steps: respectively selecting a small amount of bacterial spores to be washed out in sterile normal saline, scattering glass beads and preparingAdjusting the concentration of the bacteria forming suspension to 107CFU/mL, spare.
And (3) carrying out dry heat sterilization on a circular blank filter paper sheet with the diameter of 6mm at 160 ℃, and storing the blank filter paper sheet for later use under the aseptic condition. 0.1mL of each activated experimental bacterial suspension with the bacterial liquid concentration adjusted is sucked by a sterile pipettor and added into a culture dish poured with the culture medium, and the bacterial suspension is uniformly coated by a self-made glass coater sterilized by dry heat. And then, clamping the filter paper sheets by using sterile tweezers, putting the filter paper sheets into different bacteria-containing culture dishes, and sucking 10 mu L of biological sterilization hand sanitizer onto each filter paper sheet by using a sterile pipettor, wherein each bacterium is made into two dishes in parallel. The corresponding extraction solvent was then used as a negative control. Culturing the bacteria in a biochemical incubator at a constant temperature of 37 ℃ for 24h, measuring the diameter of a bacteriostatic circle by a cross method, and taking an average value.
Free radical scavenging test:
the biological sterilization hand sanitizer is prepared into a sample solution with the mass concentration of 0.5% by using water for experiment. 4.5mL of Tris-HCl buffer (0.05 mol/L, pH 8.2) was preheated in a water bath at 25 ℃ for 20 min. Then adding 1mL of sample solution and 0.4mL of 25mmol/L pyrogallol solution, mixing uniformly, reacting in a water bath at 25 ℃ for 5min, and adding 1.0mL of 8mol/L HCl to terminate the reaction. Absorbance values were measured at 299nm with Tris-HCl buffer as a reference. Blank replaced the sample with 1mL of water. The clearance (D) was calculated according to equation (2).
Superoxide anion radical scavenging rate (%) [1- (a2/a1) ] × 100% formula (2)
In the formula: a1 is the absorbance value of the blank; a2 is the absorbance value of the sample.
In the embodiment, the eucalyptus leaves are the eucalyptus leaves provided by the Chang Fu pharmaceutical sales company Limited in the Bozhou city, Sichuan of origin.
In the examples, the polyoxyethylene nonylphenol ether is polyoxyethylene nonylphenol ether having a model number of NP-10, which is provided by Wuhana white pharmaceutical chemical Co.
The cocamidopropyl betaine in the embodiment is cocamidopropyl betaine with CAB-35, which is provided by New materials of lion-mountain of south China sea in Foshan City.
The glycerol in the examples was provided as analytically pure glycerol from Jining Macromin chemical Co.
In the examples, vitamin A is vitamin A provided by Shaanxi Furan Natural products Co., Ltd, with the model number SF.
In the embodiment, the sodium chloride is medical-grade sodium chloride provided by Guansu actual Co, Heyunggang.
In the embodiment, the propolis flavone is 80 wt% propolis flavone provided by Xian Aino pharmaceutical science and technology Limited liability company.
In the examples, the apple polyphenol is 98 wt% of apple polyphenol provided by Shaanxi forest Freund Natural products Co.
In the embodiment, the adopted instrument for ultrahigh pressure extraction is an ultrahigh pressure extraction device with the model number of IDJ-300S provided by Shanghai Shuiyou ultrahigh pressure mechanical equipment company Limited.
Example 1
The production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a 30-mesh sieve to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into deionized water, and soaking for 4 hours at the temperature of 35 ℃, wherein the mass ratio of the eucalyptus leaf powder to the deionized water is 1: 20, obtaining a leaching solution; filtering the leaching solution by 300-mesh filter cloth to obtain filtrate; concentrating the filtrate at 60 deg.C under 0.06MPa for 5 hr to obtain concentrated solution; centrifuging the concentrated solution at a rotation speed of 5000 r/min for 15 min, removing the precipitate, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 3.5 parts by weight of eucalyptus leaf extract, 2 parts by weight of cocamidopropyl betaine, 2 parts by weight of glycerol, 0.06 part by weight of propolis flavone, 0.05 part by weight of vitamin A, 3 parts by weight of sodium chloride and 95 parts by weight of deionized water, and stirring for 30 minutes at the rotating speed of 400 revolutions per minute to uniformly mix to obtain the biological sterilization hand sanitizer.
Example 2
The production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a 30-mesh sieve to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into deionized water, and soaking for 4 hours at the temperature of 35 ℃, wherein the mass ratio of the eucalyptus leaf powder to the deionized water is 1: 20; soaking, transferring into plastic bag, exhausting bubbles, sealing, placing in an ultrahigh pressure extraction device, increasing pressure to 200MPa at a speed of 50MPa/min, maintaining pressure for 3min, instantly relieving pressure, and performing ultrahigh pressure extraction to obtain ultrahigh pressure extractive solution; filtering the ultrahigh-pressure extracting solution by adopting 300-mesh filter cloth to obtain filtrate; concentrating the filtrate at 60 deg.C under 0.06MPa for 5 hr to obtain concentrated solution; centrifuging the concentrated solution at a rotation speed of 5000 r/min for 15 min, removing the precipitate, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 3.5 parts by weight of eucalyptus leaf extract, 2 parts by weight of cocamidopropyl betaine, 2 parts by weight of glycerol, 0.06 part by weight of propolis flavone, 0.05 part by weight of vitamin A, 3 parts by weight of sodium chloride and 95 parts by weight of deionized water, and stirring for 30 minutes at the rotating speed of 400 revolutions per minute to uniformly mix to obtain the biological sterilization hand sanitizer.
Example 3
The production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a 30-mesh sieve to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into a nonylphenol polyoxyethylene ether aqueous solution, and soaking for 4 hours at the temperature of 35 ℃, wherein the mass ratio of the eucalyptus leaf powder to the nonylphenol polyoxyethylene ether aqueous solution is 1: 20; soaking, transferring into plastic bag, exhausting bubbles, sealing, placing in an ultrahigh pressure extraction device, increasing pressure to 200MPa at a speed of 50MPa/min, maintaining pressure for 3min, instantly relieving pressure, and performing ultrahigh pressure extraction to obtain ultrahigh pressure extractive solution; filtering the ultrahigh-pressure extracting solution by adopting 300-mesh filter cloth to obtain filtrate; concentrating the filtrate at 60 deg.C under 0.06MPa for 5 hr to obtain concentrated solution; centrifuging the concentrated solution at a rotation speed of 5000 r/min for 15 min, removing the precipitate, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 3.5 parts by weight of eucalyptus leaf extract, 2 parts by weight of cocamidopropyl betaine, 2 parts by weight of glycerol, 0.06 part by weight of propolis flavone, 0.05 part by weight of vitamin A, 3 parts by weight of sodium chloride and 95 parts by weight of deionized water, and stirring for 30 minutes at the rotating speed of 400 revolutions per minute to uniformly mix to obtain the biological sterilization hand sanitizer.
The mass fraction of the nonylphenol polyoxyethylene ether in the nonylphenol polyoxyethylene ether aqueous solution is 3.5%. The preparation method comprises the following steps: adding nonylphenol polyoxyethylene ether into deionized water according to the proportion and uniformly mixing to obtain the finished product.
Comparative example 1
The production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a 30-mesh sieve to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into a nonylphenol polyoxyethylene ether aqueous solution, and soaking for 4 hours at the temperature of 35 ℃, wherein the mass ratio of the eucalyptus leaf powder to the nonylphenol polyoxyethylene ether aqueous solution is 1: 20, obtaining a leaching solution; filtering the leaching solution by 300-mesh filter cloth to obtain filtrate; concentrating the filtrate at 60 deg.C under 0.06MPa for 5 hr to obtain concentrated solution; centrifuging the concentrated solution at a rotation speed of 5000 r/min for 15 min, removing the precipitate, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 3.5 parts by weight of eucalyptus leaf extract, 2 parts by weight of cocamidopropyl betaine, 2 parts by weight of glycerol, 0.06 part by weight of propolis flavone, 0.05 part by weight of vitamin A, 3 parts by weight of sodium chloride and 95 parts by weight of deionized water, and stirring for 30 minutes at the rotating speed of 400 revolutions per minute to uniformly mix to obtain the biological sterilization hand sanitizer.
The mass fraction of the nonylphenol polyoxyethylene ether in the nonylphenol polyoxyethylene ether aqueous solution is 3.5%. The preparation method comprises the following steps: adding nonylphenol polyoxyethylene ether into deionized water according to the proportion and uniformly mixing to obtain the finished product.
Example 4
The production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a 30-mesh sieve to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into a nonylphenol polyoxyethylene ether aqueous solution, and soaking for 4 hours at the temperature of 35 ℃, wherein the mass ratio of the eucalyptus leaf powder to the nonylphenol polyoxyethylene ether aqueous solution is 1: 20; soaking, transferring into plastic bag, exhausting bubbles, sealing, placing in an ultrahigh pressure extraction device, increasing pressure to 200MPa at a speed of 50MPa/min, maintaining pressure for 3min, instantly relieving pressure, and performing ultrahigh pressure extraction to obtain ultrahigh pressure extractive solution; filtering the ultrahigh-pressure extracting solution by adopting 300-mesh filter cloth to obtain filtrate; concentrating the filtrate at 60 deg.C under 0.06MPa for 5 hr to obtain concentrated solution; centrifuging the concentrated solution at a rotation speed of 5000 r/min for 15 min, removing the precipitate, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 3.5 parts by weight of eucalyptus leaf extract, 2 parts by weight of cocamidopropyl betaine, 2 parts by weight of glycerol, 0.06 part by weight of apple polyphenol, 0.05 part by weight of vitamin A, 3 parts by weight of sodium chloride and 95 parts by weight of deionized water, and stirring for 30 minutes at the rotating speed of 400 revolutions per minute to uniformly mix to obtain the biological sterilization hand sanitizer.
The mass fraction of the nonylphenol polyoxyethylene ether in the nonylphenol polyoxyethylene ether aqueous solution is 3.5%. The preparation method comprises the following steps: adding nonylphenol polyoxyethylene ether into deionized water according to the proportion and uniformly mixing to obtain the finished product.
Example 5
The production process of the biological sterilization hand sanitizer comprises the following steps:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a 30-mesh sieve to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into a nonylphenol polyoxyethylene ether aqueous solution, and soaking for 4 hours at the temperature of 35 ℃, wherein the mass ratio of the eucalyptus leaf powder to the nonylphenol polyoxyethylene ether aqueous solution is 1: 20; soaking, transferring into plastic bag, exhausting bubbles, sealing, placing in an ultrahigh pressure extraction device, increasing pressure to 200MPa at a speed of 50MPa/min, maintaining pressure for 3min, instantly relieving pressure, and performing ultrahigh pressure extraction to obtain ultrahigh pressure extractive solution; filtering the ultrahigh-pressure extracting solution by adopting 300-mesh filter cloth to obtain filtrate; concentrating the filtrate at 60 deg.C under 0.06MPa for 5 hr to obtain concentrated solution; centrifuging the concentrated solution at a rotation speed of 5000 r/min for 15 min, removing the precipitate, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 3.5 parts by weight of eucalyptus leaf extract, 2 parts by weight of cocamidopropyl betaine, 2 parts by weight of glycerol, 0.048 part by weight of propolis flavone, 0.012 part by weight of apple polyphenol, 0.05 part by weight of vitamin A, 3 parts by weight of sodium chloride and 95 parts by weight of deionized water, stirring at the rotating speed of 400 revolutions per minute for 30 minutes, and uniformly mixing to obtain the biological sterilization hand sanitizer. The performance test result of the biological sterilization hand sanitizer is as follows: the diameter of a bacteriostatic circle of staphylococcus aureus is 16mm, the diameter of a bacteriostatic circle of escherichia coli is 18mm, and the scavenging rate of superoxide anion free radicals is 95.3%.
The mass fraction of the nonylphenol polyoxyethylene ether in the nonylphenol polyoxyethylene ether aqueous solution is 3.5%. The preparation method comprises the following steps: adding nonylphenol polyoxyethylene ether into deionized water according to the proportion and uniformly mixing to obtain the finished product.
Test example 1
Performance tests were performed on the biocidal hand sanitizers prepared in examples 1-4 and comparative example 1. Specific results are shown in table 1.
Table 1: test result table
The performance of the hand sanitizer is greatly improved by adopting ultrahigh pressure extraction, which may be caused by that ultrahigh pressure difference is formed inside and outside solid tissue cells during ultrahigh pressure extraction, and an extraction solvent rapidly permeates into vascular bundles and glandular cells inside plants under the promotion of ultrahigh pressure; with the rapid increase of pressure, the cell volume is compressed, and if the deformation limit is exceeded, the cell is broken, the substance in the cell is dissolved by contacting with the solvent, and the effective component is dissolved in the extraction solvent. When the aqueous solution of the polyoxyethylene nonyl phenyl ether is used for soaking the eucalyptus leaf powder, the polyoxyethylene nonyl phenyl ether can swell the plant material and can be thoroughly diffused into the solid matrix, so that the mass transfer coefficient of the soluble component desorbed from the plant matrix into water is increased.
Claims (8)
1. The production process of the biological sterilization hand sanitizer is characterized by comprising the following steps of:
s1, crushing the eucalyptus leaves, and sieving the crushed eucalyptus leaves with a sieve of 10-50 meshes to obtain eucalyptus leaf powder; adding the eucalyptus leaf powder into a nonylphenol polyoxyethylene ether aqueous solution, and soaking for 3-5 hours at the temperature of 25-55 ℃, wherein the mass ratio of the eucalyptus leaf powder to the nonylphenol polyoxyethylene ether aqueous solution is 1: (10-30); soaking, transferring into plastic bag, removing bubbles, sealing, and extracting under ultrahigh pressure; filtering, concentrating, centrifuging, and collecting supernatant to obtain folium Eucalypti Globueli extract;
s2, taking 2-5 parts by weight of eucalyptus leaf extract, 1.5-2.5 parts by weight of cocamidopropyl betaine, 1.5-2.5 parts by weight of glycerol, 0.02-0.08 part by weight of biological bactericide, 0.03-0.09 part by weight of vitamin A, 2-4 parts by weight of sodium chloride and 90-100 parts by weight of water, and uniformly mixing by stirring at the rotation speed of 300 plus 500 rpm for 20-40 minutes;
the biological bactericide is propolis flavone and/or apple polyphenol.
2. The process for producing the biological sterilization hand sanitizer according to claim 1, wherein: the pressure of the ultrahigh pressure extraction is 180-220MPa, and the time is 2-5 minutes.
3. The process for producing the biological sterilization hand sanitizer according to claim 1, wherein: the filter cloth for filtering is 250 meshes and 350 meshes.
4. The process for producing the biological sterilization hand sanitizer according to claim 1, wherein: the rotation speed of the centrifugation is 4000-6000 rpm, and the time is 10-20 minutes.
5. The process for producing the biological sterilization hand sanitizer according to claim 1, wherein: the vacuum degree of the concentration is 0.04-0.08MPa, the temperature is 55-65 ℃, and the time is 3-7 hours.
6. The process for producing the biological sterilization hand sanitizer according to claim 1, wherein: the biological bactericide consists of propolis flavone 75-85 wt% and apple polyphenol 15-25 wt%.
7. The process for producing the biological sterilization hand sanitizer according to claim 1, wherein: the mass fraction of the nonylphenol polyoxyethylene ether in the nonylphenol polyoxyethylene ether aqueous solution is 2-5%.
8. A biological sterilization hand sanitizer prepared by the production process of any one of claims 1 to 7.
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| CN1437925A (en) * | 2003-03-08 | 2003-08-27 | 梁栋 | Wash cosmetic of Folium Eucalypti Globuli aqueous extract |
| CN104644458A (en) * | 2014-06-10 | 2015-05-27 | 莫治玲 | Hand sanitizer |
| CN105686966A (en) * | 2016-01-15 | 2016-06-22 | 王芳 | Hand sanitizer for medical clinical laboratory |
| CN106551797A (en) * | 2016-11-14 | 2017-04-05 | 然久生物科技(上海)有限公司 | Hand cleanser and preparation method thereof |
| CN106916649A (en) * | 2015-12-25 | 2017-07-04 | 山东龙力生物科技股份有限公司 | A kind of washing product |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437925A (en) * | 2003-03-08 | 2003-08-27 | 梁栋 | Wash cosmetic of Folium Eucalypti Globuli aqueous extract |
| CN104644458A (en) * | 2014-06-10 | 2015-05-27 | 莫治玲 | Hand sanitizer |
| CN106916649A (en) * | 2015-12-25 | 2017-07-04 | 山东龙力生物科技股份有限公司 | A kind of washing product |
| CN105686966A (en) * | 2016-01-15 | 2016-06-22 | 王芳 | Hand sanitizer for medical clinical laboratory |
| CN106551797A (en) * | 2016-11-14 | 2017-04-05 | 然久生物科技(上海)有限公司 | Hand cleanser and preparation method thereof |
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