CN102614214A - Composite povidone iodine tablet and preparation method thereof - Google Patents
Composite povidone iodine tablet and preparation method thereof Download PDFInfo
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- CN102614214A CN102614214A CN2012100622104A CN201210062210A CN102614214A CN 102614214 A CN102614214 A CN 102614214A CN 2012100622104 A CN2012100622104 A CN 2012100622104A CN 201210062210 A CN201210062210 A CN 201210062210A CN 102614214 A CN102614214 A CN 102614214A
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- povidone iodine
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Abstract
The invention belongs to the technical field of disinfectors and particularly relates to a composite povidone iodine tablet and a preparation method thereof. The composite povidone iodine tablet comprises the following components in parts by weight: 5 to 50 parts of povidone iodine, 5 to 30 parts of heat-releasing covering agent, 10 to 30 parts of effervescing agent, 15 to 40 parts of acidulant, 0 to 8 parts of synergistic agent and 5 to 25 parts of filler, wherein the heat-releasing covering agent is any one of or a mixture of anhydrous magnesium chloride and anhydrous calcium chloride; the effervescing agent is any one of or a mixture of sodium bicarbonate, sodium carbonate and magnesium bicarbonate; the acidulant is any one of or a mixture of citric acid, tartaric acid, sulfamic acid and sodium bisulfate; the synergistic agent is any one of or a mixture of sodium dodecyl sulfate, ethoxy modified polytrisiloxane powder and boric acid; and the filler is any one of or a mixture of sodium sulfate and sodium chloride. The composite povidone iodine tablet is stable, safe, corrosion-resistant, high in dissolution rate and reaction conversion rate and convenient to use.
Description
Technical field
The present invention relates to a kind of disinfectant technical field, relate in particular to a kind of compound povidone iodine tablet and preparation method thereof.
Background technology
Povidone iodine existing oneself become generally acknowledge in the world efficient, wide spectrum, nontoxic antibacterial, it has extremely strong sterilizing power and fungicidal spectrum widely.It is embraced etc. staphylococcus aureus, gonococcus, bacillus pyocyaneus, treponema pallidum, hepatitis B virus, HIV, trichomonas vaginitis, bud all has stronger killing action; In the in vitro tests that clinical common antibacterial is carried out, almost there is not a kind of antibacterial not to be killed.Povidone iodine is one of povidone iodine of developing the earliest, and it has many excellent characteristic, and user is acceptable strong, has kept the good bactericidal properties of iodine, at home and abroad is widely used in the hospital disinfection.This types of drugs is own is at present included by version Chinese Pharmacopoeia in 2005, is a kind of outstanding skin antiseptic, and povidone iodine also is very important veterinary drug, and consumption is very big at present.
Povidone iodine is that I and polyethylene adjoin the complex that pyrrolidone forms by hydrogen bond and other graviational interactions with the form of complexation.The betagen solution agent is the exterior-applied formulation that the most often uses at present, in actual clinical is used, has widely and uses, yet in the solution of external; Available iodine is degraded easily; Usually have wild effect, curative effect reduces then, and the effect duration of betagen solution is obviously shortened.And the betagen solution pH value is very unstable, and fall is very big, poor stability, and the shelf-life is short.
Summary of the invention
The present invention is directed to shortcoming of the prior art a kind of compound povidone iodine tablet and preparation method thereof is provided, it can make Acu-Dyne stability improve greatly, and the shelf-life prolongs, and content is accurate, and metering easily.
The present invention is achieved through following technical scheme:
A kind of compound povidone iodine tablet of the present invention, it comprises following material component by weight:
Povidone iodine 5～50, heat release covering 5～30, effervescent 10～30, acidulant 15～40, synergist 0～8, filler 5～25.
Said povidone iodine is pure article povidone iodine powder, is the host in the tablet, plays main effect.
Said heat release covering is a kind of or its mixture in anhydrous magnesium chloride, the anhydrous calcium chloride; Said heat release covering had both played the coating effect to povidone iodine powder and effervescent, made system more stable, and also heat release in course of dissolution has improved local water temperature, and the slow povidone iodine powder of dissolving is dissolved in the water very soon.
Said effervescent is a kind of or its mixture in sodium bicarbonate, sodium carbonate, the magnesium bicarbonate.Said effervescent produces carbon dioxide in when dissolving with the acidulant reaction, produces local effervescent effect, around tablet, produces agitation effects, the raising reaction power to dissolving the reactant that.In addition also can quicken the course of dissolution of tablet.
Said acidulant is a kind of or its mixture in citric acid, tartaric acid, sulfamic acid, the sodium bisulfate.The water-soluble generation hydrion of said acidulant; Can produce carbon dioxide with the effervescent reaction on the one hand; Produce local effervescent effect, around tablet, produce agitation effects, improve reaction power dissolving the reactant that; The sour environment built of acidulant has Stabilization to povidone iodine on the other hand, can guarantee the action effect of povidone iodine.
Said synergist is that dodecyl sodium sulfate, ethyoxyl modification gather a kind of or its mixture in trisiloxanes powder, the boric acid.Said synergist has good penetration, wettability; When product when using as disinfectant, the adding of synergist is very important to the raising of product serviceability, it can reduce solution surface tension; Improve wettability and the permeability of solution, strengthen sterilizing ability body surface.
Said filler is a kind of or its mixture in sodium sulfate, the sodium chloride.Said filler can make sheeting process accomplish smoothly, has played the effect of binding agent.
Preferably, described a kind of compound povidone iodine tablet, it comprises following material component by weight:
Povidone iodine 10～40, heat release covering 10～25, effervescent 12～25, acidulant 20～30, synergist 1～4, filler 8～18.
Preferably, described a kind of compound povidone iodine tablet, it comprises following material component by weight:
Povidone iodine 25, anhydrous magnesium chloride 20, sodium bicarbonate 18, sodium bisulfate 25, dodecyl sodium sulfate 2, sodium sulfate 10.
The method for preparing of above-mentioned compound povidone iodine tablet, it may further comprise the steps:
A. povidone iodine, heat release covering, effervescent, the synergist with formula ratio is added in the blender, mixes 10～20 minutes, and the heat release covering coats processing to povidone iodine and effervescent.
B. add the acidulant and the filler of formula ratio in the blender in step a, mixed 10～20 minutes, obtain the povidone iodine mixed-powder.
C. the mixed-powder of getting step b is pressed into tablet on tablet machine, the production operation ambient humidity control of tablet is less than 35%R.H., and pressure is 2～10T/cm2.Tabletting can be pressed into different content proportioning or different quality, difform tablet according to different use occasions.Tablet quality can be from several tens grams that restrain at zero point.The shape of tablet can be pressed into the special-shaped tablets of circle, pole shape, ellipticity and other shape of different-diameter.
D. use Aluminum-plastic composite bag or plastic bottle or other effervescent tablet to be packed at a distance from material or container wet, lucifuge.
Preferably, the method for preparing of described a kind of compound povidone iodine tablet, used each material component is a powder, and the order number of said powder is 80～150, and its water content is less than 0.3%.
Compound povidone iodine tablet according to the invention has made the povidone iodine of solution-type into solid tablet, and Acu-Dyne stability is improved greatly, and the shelf-life prolongs, and content is accurate, and metering easily.
Compound povidone iodine tablet of the present invention is progressively dissolving from outside to inside when dissolving, and the related component in the tablet can be realized the constant speed course of dissolution, the reaction while dissolving; And tablet produces a certain amount of carbon dioxide in course of dissolution, can accelerate the dissolution velocity of tablet on the one hand; Produce local effervescent effect on the other hand; Produce agitation effects to dissolving the reactant that around the tablet, improve reaction power, make the course of dissolution of tablet promptly become the reaction conversion process of raw material; And the heat release in course of dissolution of heat release covering improved local temperature, and the povidone iodine powder can be dissolved fast.Obtain certain density betagen solution after the dissolving.
The present invention compared with prior art has following significant advantage:
(1) strengthened stability of formulation, long shelf-life.
(2) reduced the corrosivity of product, the application scenario of having widened product greatly.
(3) dissolution velocity is fast, and reaction conversion ratio is high, has reduced the reaction difficulty.
(4) content is accurate, and metering easily, and is easy to use.
(5) be convenient to transportation, storage safe.
The specific embodiment
Through specific embodiment the present invention is further described below:
A kind of compound povidone iodine tablet of the present invention, it comprises following material component by weight: povidone iodine 5～50, heat release covering 5～30, effervescent 10～30, acidulant 15～40, synergist 0～8, filler 5～25.
The method for preparing of the compound povidone iodine tablet of the present invention may further comprise the steps:
A. povidone iodine, heat release covering, effervescent, the synergist with formula ratio is added in the blender, mixes 10～20 minutes, with the heat release covering povidone iodine and effervescent coated processing.
B. in above-mentioned blender, add the acidulant and the filler of formula ratio, mixed 10～20 minutes, obtain the povidone iodine mixed-powder.
C. the mixture of getting step b is pressed into tablet on tablet machine, the production operation ambient humidity control of tablet is less than 35%R.H., and pressure is 2～10T/cm
2Tabletting can be pressed into different content proportioning or different quality, difform tablet according to different use occasions.Tablet quality can be from several tens grams that restrain at zero point; The shape of tablet can be pressed into the special-shaped tablets of circle, pole shape, ellipticity and other shape of different-diameter.
D. use Aluminum-plastic composite bag or plastic bottle or other effervescent tablet to be packed at a distance from material or container wet, lucifuge.
The order number of used each material component powder is 80～150, and water content is less than 0.3%.
Embodiment 1
Povidone iodine 25kg, anhydrous magnesium chloride 20kg, sodium bicarbonate 18kg, sodium bisulfate 25kg, dodecyl sodium sulfate 2kg, sodium sulfate 10kg.
Embodiment 2
Povidone iodine 10kg, anhydrous calcium chloride 25kg, sodium carbonate 12kg, citric acid 20kg, dodecyl sodium sulfate 1kg, sodium chloride 8kg.
Embodiment 3
Povidone iodine 40kg, anhydrous magnesium chloride 10kg, magnesium bicarbonate 25kg, tartaric acid 30kg, the ethyoxyl modification gathers trisiloxanes powder 4kg, sodium sulfate 18kg.
Embodiment 4
Povidone iodine 5kg, anhydrous calcium chloride 5kg, sodium carbonate 10kg, sodium bisulfate 15kg, dodecyl sodium sulfate 0.6kg, sodium chloride 5kg.
Embodiment 5
Povidone iodine 50kg, anhydrous magnesium chloride 30kg, sodium bicarbonate 30kg, sulfamic acid 39kg, boric acid 7kg, sodium sulfate 25kg.
Embodiment 6
Povidone iodine 30kg, anhydrous magnesium chloride 15kg, sodium bicarbonate 20kg, sulfamic acid 20kg, boric acid 5kg, sodium sulfate 15kg.
Embodiment 7
Povidone iodine 20kg, anhydrous calcium chloride 25kg, magnesium bicarbonate 25kg, tartaric acid 30kg, dodecyl sodium sulfate 4kg, sodium chloride 20kg.
Claims (5)
1. compound povidone iodine tablet is characterized in that it comprises following material component by weight:
Povidone iodine 5～50, heat release covering 5～30, effervescent 10～30, acidulant 15～40, synergist 0～8, filler 5～25;
Said heat release covering is a kind of or its mixture in anhydrous magnesium chloride, the anhydrous calcium chloride;
Said effervescent is a kind of or its mixture in sodium bicarbonate, sodium carbonate, the magnesium bicarbonate;
Said acidulant is a kind of or its mixture in citric acid, tartaric acid, sulfamic acid, the sodium bisulfate;
Said synergist is that dodecyl sodium sulfate, ethyoxyl modification gather a kind of or its mixture in trisiloxanes powder, the boric acid;
Said filler is a kind of or its mixture in sodium sulfate, the sodium chloride.
2. like claims 1 described a kind of compound povidone iodine tablet, it is characterized in that it comprises following material component by weight:
Povidone iodine 10～40, heat release covering 10～25, effervescent 12～25, acidulant 20～30, synergist 1～4, filler 8～18.
3. like claims 1 described a kind of compound povidone iodine tablet, it is characterized in that it comprises following material component by weight:
Povidone iodine 25, anhydrous magnesium chloride 20, sodium bicarbonate 18, sodium bisulfate 25, dodecyl sodium sulfate 2, sodium sulfate 10.
4. like the method for preparing of claims 1 to 3 described a kind of compound povidone iodine tablet, it is characterized in that it may further comprise the steps:
A. povidone iodine, heat release covering, effervescent, the synergist with formula ratio is added in the blender, mixes 10～20 minutes, and the heat release covering coats processing to povidone iodine and effervescent;
B. add the acidulant and the filler of formula ratio in the blender in step a, mixed 10～20 minutes, obtain the povidone iodine mixed-powder;
C. the mixed-powder of getting step b is pressed into tablet on tablet machine, the production operation ambient humidity control of tablet is less than 35%R.H., and pressure is 2～10T/cm
2
D. use Aluminum-plastic composite bag or plastic bottle or other effervescent tablet to be packed at a distance from material or container wet, lucifuge.
5. like the method for preparing of claims 4 described a kind of compound povidone iodine tablets, it is characterized in that:
Used each material component is a powder, and the order number of said powder is 80～150, and its water content is less than 0.3%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100622104A CN102614214A (en) | 2012-03-12 | 2012-03-12 | Composite povidone iodine tablet and preparation method thereof |
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| CN2012100622104A CN102614214A (en) | 2012-03-12 | 2012-03-12 | Composite povidone iodine tablet and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105084475A (en) * | 2015-07-30 | 2015-11-25 | 上海宇昂新材料科技有限公司 | Disinfection effervescent tablet with water quality purification effect and preparation method of disinfection effervescent tablet |
| CN109042728A (en) * | 2018-09-19 | 2018-12-21 | 青岛安特斯生物制药有限公司 | A kind of iodine class disinfectant and its preparation and application |
| CN110538161A (en) * | 2019-09-29 | 2019-12-06 | 石家庄卫科生物科技有限公司 | povidone iodine effervescent tablet for animal delivery room and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1729994A (en) * | 2005-07-25 | 2006-02-08 | 华中农业大学 | Povidone iodine effervescence tablet for treating milk cow colpitis, its preparation process and application |
| CN101181295A (en) * | 2007-11-22 | 2008-05-21 | 中国人民解放军海军医学研究所 | Pharmaceutical preparation of povidone iodine and preparation method thereof |
| CN102258018A (en) * | 2011-05-30 | 2011-11-30 | 河南黑马动物药业有限公司 | Disinfecting composite effervescent tablets and preparation method thereof |
-
2012
- 2012-03-12 CN CN2012100622104A patent/CN102614214A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1729994A (en) * | 2005-07-25 | 2006-02-08 | 华中农业大学 | Povidone iodine effervescence tablet for treating milk cow colpitis, its preparation process and application |
| CN101181295A (en) * | 2007-11-22 | 2008-05-21 | 中国人民解放军海军医学研究所 | Pharmaceutical preparation of povidone iodine and preparation method thereof |
| CN102258018A (en) * | 2011-05-30 | 2011-11-30 | 河南黑马动物药业有限公司 | Disinfecting composite effervescent tablets and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘玉明等: "聚维酮碘泡腾片的制备", 《中国新药杂志》, vol. 17, no. 5, 31 December 2008 (2008-12-31) * |
| 莫莉: "聚维酮碘阴道泡腾片和复方聚维酮碘凝胶的研制及应用研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》, no. 04, 15 April 2009 (2009-04-15), pages 050 - 89 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105084475A (en) * | 2015-07-30 | 2015-11-25 | 上海宇昂新材料科技有限公司 | Disinfection effervescent tablet with water quality purification effect and preparation method of disinfection effervescent tablet |
| CN109042728A (en) * | 2018-09-19 | 2018-12-21 | 青岛安特斯生物制药有限公司 | A kind of iodine class disinfectant and its preparation and application |
| CN109042728B (en) * | 2018-09-19 | 2021-01-01 | 青岛安特斯生物制药有限公司 | Iodine disinfectant and preparation and use method thereof |
| CN110538161A (en) * | 2019-09-29 | 2019-12-06 | 石家庄卫科生物科技有限公司 | povidone iodine effervescent tablet for animal delivery room and preparation method thereof |
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Application publication date: 20120801 |