CN102715179A - Sterilization composition containing cyazofamid and pyraclostrobine and application thereof - Google Patents
Sterilization composition containing cyazofamid and pyraclostrobine and application thereof Download PDFInfo
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- CN102715179A CN102715179A CN2012102188853A CN201210218885A CN102715179A CN 102715179 A CN102715179 A CN 102715179A CN 2012102188853 A CN2012102188853 A CN 2012102188853A CN 201210218885 A CN201210218885 A CN 201210218885A CN 102715179 A CN102715179 A CN 102715179A
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- pyraclostrobin
- cyanogen frost
- frost azoles
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- azoles
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Abstract
The invention belongs to the technical field of pesticide, and specifically relates to a sterilization composition containing cyazofamid and pyraclostrobine, and application of the sterilization composition in the aspects of controlling fungal diseases of crops. The weight ratio of cyazofamid to pyraclostrobine in the composition is 50:1 to 1:50; and by compounding, the composition has synergistic action, is wide in application range, low in cost and good in effect, can be used for controlling downy mildew, epidemic disease and other diseases generated by phycomycetes and other fungi on grape, cucumber, tomato, potato and other crops, has excellent control effect and simultaneously has better action on delaying the pesticide resistance of pathogenic bacteria.
Description
Technical field
The invention belongs to technical field of pesticides, be specifically related to a kind of pyraclostrobin and cyanogen frost azoles that contains and carry out composite bactericidal composition, and the application aspect control farm crop fungus disease.
Background technology
Pyraclostrobin (Pyraclostrobin); Claim pyraclostrobin again, chemical name N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] oxygen methyl] phenyl]-N-methoxyl group methyl carbamate belongs to the methoxy acrylic bactericide that has the pyrazoles structure concurrently; The electronics transmission suppresses mitochondrial breathing between thin race pigment b and C1 through stoping; The interference cell energy is supplied with, and makes cell death, thus the performance bactericidal action.Pyraclostrobin has excellent protection, treatment, interior suction conduction and resistance of rainwater washing against performance, and the sterilization wide spectrum, and nearly all Mycophyta (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti) disease is all demonstrated good active; Simultaneously can be to making the positive physiological regulatory action of deposits yields.Not only toxicity is low for it, to non-target organism safety, and also friendly to user and Environmental security.
Cyanogen frost azoles (Cyazofamid) chemical name 4-chloro-2-cyanic acid-5-p-methylphenyl-imidazoles-1-N, N-dimethyl methyl acid amides belongs to the imidazoles bactericide.Cyanogen frost azoles is the mitochondrial respiratory inhibitor, is Qi inhibitor among the cytochrome b c1, is different from methoxy acrylate (being Qo inhibitor among the cytochrome b c1).All vegetative stages of oomycetes are all had effect, and the germ that metalaxyl is produced resistance or sensitivity all has activity, has certain interior suction and therapeutic activity; Lasting period is long, and resistance of rainwater washing against is to crop, the mankind, Environmental security; But long-term single use can make germ that it is developed immunity to drugs unavoidably.
Above-mentioned two kinds of medicaments cause drug effect obviously to descend because long-term use separately causes the drug-fast generation of germ easily; Thereby cause dosage to rise greatly, the sprinkling cycle shortens, and result of use is poor; Increased cost, the use of a large amount of agricultural chemicals makes that the germ resistance is more serious; Also environment is affected, the medicament residue of agricultural product also increases, and has influence on health and the normal existence of the mankind, animal etc.; Pyraclostrobin and cyanogen frost azoles are carried out composite use control corps diseases, do not appear in the newspapers as yet both at home and abroad.
Summary of the invention
The objective of the invention is to provide a kind of and carry out composite bactericidal composition and application thereof by pyraclostrobin and cyanogen frost azoles to the problems referred to above; Said composition plays synergistic effect through composite; Applied widely, cost is low, effective; Can be used to prevent and treat diseases such as downy mildew that fungies such as Phycomycetes produce, eqpidemic disease on various crop such as grape, cucumber, tomato, potato, have good control efficiency, simultaneously the pesticide resistance that delays pathogen is had better action.
Among the present invention, the cyanogen frost azoles of being mentioned, the weight of pyraclostrobin, the weight of active ingredient etc. all refer to the weight of rolling over after hundred, i.e. the weight of active principle.
The bactericidal composition that contains cyanogen frost azoles and pyraclostrobin of the present invention, its active ingredient consists of cyanogen frost azoles and pyraclostrobin, and the weight ratio of described pyraclostrobin and cyanogen frost azoles is pyraclostrobin: cyanogen frost azoles=50: 1～1: 50.
As preferably, the weight ratio of described pyraclostrobin and cyanogen frost azoles is pyraclostrobin: cyanogen frost azoles=10: 1～1: 10.
Wherein, the weight percentage of active ingredient is 1%～90% in the said composition.
The said composition formulation comprises wetting powder, suspending agent, water dispersible granules, adds auxiliary agent and excipient, and the production technology of all knowing according to those skilled in the art can be made into required formulation.
This bactericidal composition is used to prevent and treat the fungal disease on the crop, be used to prevent and treat on grape, cucumber, tomato, the potato by fungus-caused downy mildew, eqpidemic disease disease, described fungi can be fungies such as Phycomycetes.
Beneficial effect of the present invention is: carry out pyraclostrobin and two kinds of bactericide of cyanogen frost azoles composite; Composite composition has obvious synergistic effect in certain proportion; The more single agent of control efficiency is significantly improved; Reduced dosage and drug cost, reduced harmful effect environment.And interracial structure differs bigger, and the application of complex composition helps delaying drug-fast generation of germ and development.This bactericidal composition can be used to prevent and treat diseases such as downy mildew that fungies such as Phycomycetes produce, eqpidemic disease on various crop such as grape, cucumber, tomato, potato, have good control efficiency.
Studied the indoor virulence of pyraclostrobin with the mycelial growth rate method with the composite mixture Phytophthora infestans of the different proportionings of cyanogen frost azoles; Experimental technique adopts the abundant method calculating co-toxicity coefficient of Sun Yun (CTC) to estimate and uses effect with; The CTC value has synergistic effect greater than 120 o'clock mixtures; Less than 80 o'clock be antagonism, have summation action in the time of between 80～120.
Concrete grammar is following:
Get the soup for preparing and place 100ml 50-60 ℃ of PDA sterilising medium; Shake up, pour in the sterilization culture dish of diameter 60mm, after the cooled and solidified; Moving respectively delivers a child grows unanimity, diameter is the bacterium cake of 4mm; As blank, all operations all carries out sterile working at superclean bench with the sterilising medium that adds the equivalent coordinative solvent, and 3 repetitions are established in every processing.Put into 27 ℃ of constant incubators and cultivate after 3-8 days, adopt the right-angled intersection method to measure colony diameter, calculate bacteriostasis rate, EC
50, relevant parameter such as CTC, the relevant calculation formula is following:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-handle pure amount of growth) * 100/ contrast] * 100%
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) * B the percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
The toxicity test table of table 1 pyraclostrobin and cyanogen frost azoles list mixture Phytophthora infestans
Visible by table 1; Pyraclostrobin and cyanogen frost azoles are composite; Phytophthora infestans has good indoor virulence, and the CTC value of nine proportionings shows that all above 120 these two bactericide have good synergistic effects under this proportioning; Can find out also simultaneously that in composition different its synergistic effects along with pyraclostrobin and the white azoles ratio of cyanogen also are different, mixed ratio synergy between 10: 1～1: 10 is particularly remarkable.
Embodiment
Below in conjunction with embodiment the present invention is described further, but the present invention is not limited thereto, the formulation preparation method among the embodiment is conventional method.
Embodiment 1:10% pyraclostrobin cyanogen frost azole suspending agent comprises following component by weight:
With whole mixing of materials, the back that stirs joins sand mill to material and carries out sand milling, makes material reach 2～5 μ m fineness, makes 10% pyraclostrobin cyanogen frost azole suspending agent.
Embodiment 2:22% pyraclostrobin cyanogen frost azoles water dispersible granules comprises following component by weight:
Above-mentioned mixed by prescription is even, become wetting powder through comminution by gas stream, add the granulation of a certain amount of water extrusion again, after dry screened, obtain 22% pyraclostrobin cyanogen frost azoles water dispersible granules.
Embodiment 3:51% pyraclostrobin cyanogen frost azoles wetting powder comprises following component by weight:
Said components is carried out comminution by gas stream, make 51% pyraclostrobin cyanogen frost azoles wetting powder.
Embodiment 4:76.5% pyraclostrobin cyanogen frost azoles wetting powder comprises following component by weight:
Said components is carried out comminution by gas stream, make 76.5% pyraclostrobin cyanogen frost azoles wetting powder.
Test Example: the test of pesticide effectiveness of the mixture control cucumber downy mildew of the different proportionings of pyraclostrobin and cyanogen frost azoles
4 kinds of mixtures that the embodiment of the invention is obtained carry out the test of pesticide effectiveness, adopt the greenhouse pot culture cucumber seedling, measure the control efficiency of single mixture of pyraclostrobin and cyanogen frost azoles to cucumber downy mildew.When cucumber grows to 3～4 leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out the foliar spray processing, inoculate pathogen after 24 hours, preserve moisture and cultivate 7d " Invest, Then Investigate " result, the result sees table 2.
The control efficiency table of table 2 pair cucumber downy mildew
Can find out that from table 2 mixture preparation of pyraclostrobin and cyanogen frost azoles can effectively be prevented and treated cucumber downy mildew, and obviously is superior to the control efficiency of single agent.
Claims (6)
1. bactericidal composition that contains cyanogen frost azoles and pyraclostrobin, its active ingredient consists of cyanogen frost azoles and pyraclostrobin, and described pyraclostrobin is pyraclostrobin with the weight ratio of the white azoles of cyanogen: the white azoles of cyanogen=50: 1～1: 50.
2. bactericidal composition according to claim 1 is characterized in that, the weight ratio of described pyraclostrobin and cyanogen frost azoles is pyraclostrobin: cyanogen frost azoles=10: 1～1: 10.
3. bactericidal composition according to claim 1 and 2 is characterized in that, the weight percentage of described active ingredient is 1%～90%.
4. bactericidal composition according to claim 1 is characterized in that the said composition formulation comprises wetting powder, suspending agent, water dispersible granules.
5. bactericidal composition as claimed in claim 1 is used to prevent and treat the fungal disease on the crop.
6. bactericidal composition as claimed in claim 1, be used to prevent and treat on grape, cucumber, tomato, the potato by fungus-caused downy mildew, eqpidemic disease disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102188853A CN102715179A (en) | 2012-06-29 | 2012-06-29 | Sterilization composition containing cyazofamid and pyraclostrobine and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102188853A CN102715179A (en) | 2012-06-29 | 2012-06-29 | Sterilization composition containing cyazofamid and pyraclostrobine and application thereof |
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| CN102715179A true CN102715179A (en) | 2012-10-10 |
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| CN2012102188853A Pending CN102715179A (en) | 2012-06-29 | 2012-06-29 | Sterilization composition containing cyazofamid and pyraclostrobine and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719091A (en) * | 2013-12-09 | 2014-04-16 | 江阴苏利化学股份有限公司 | Sterilization composite containing cyazofamid and fludioxonil |
| CN104106583A (en) * | 2013-04-22 | 2014-10-22 | 陕西美邦农药有限公司 | High-efficiency sterilization composition containing tricyclopyricarb |
| CN112753706A (en) * | 2020-12-31 | 2021-05-07 | 河北威远生物化工有限公司 | Pyraclostrobin and cyazofamid suspending agent and preparation method thereof |
| US20220071212A1 (en) * | 2017-05-02 | 2022-03-10 | Corteva Agriscience Llc | Synergistic mixtures for fungal controls in cereals |
| CN114642210A (en) * | 2021-04-06 | 2022-06-21 | 山东统防生物科技有限公司 | Suspending agent containing methoxy carbamate and cyazofamid and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1484492A (en) * | 2001-01-16 | 2004-03-24 | �����ɷ� | Fungicidal mixture |
| CN101653118A (en) * | 2009-07-31 | 2010-02-24 | 深圳诺普信农化股份有限公司 | Compound synergistic bactericidal composition |
| CN102626098A (en) * | 2012-03-28 | 2012-08-08 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing pyraclostrobin |
-
2012
- 2012-06-29 CN CN2012102188853A patent/CN102715179A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1484492A (en) * | 2001-01-16 | 2004-03-24 | �����ɷ� | Fungicidal mixture |
| CN101653118A (en) * | 2009-07-31 | 2010-02-24 | 深圳诺普信农化股份有限公司 | Compound synergistic bactericidal composition |
| CN102626098A (en) * | 2012-03-28 | 2012-08-08 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing pyraclostrobin |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104106583A (en) * | 2013-04-22 | 2014-10-22 | 陕西美邦农药有限公司 | High-efficiency sterilization composition containing tricyclopyricarb |
| CN103719091A (en) * | 2013-12-09 | 2014-04-16 | 江阴苏利化学股份有限公司 | Sterilization composite containing cyazofamid and fludioxonil |
| US20220071212A1 (en) * | 2017-05-02 | 2022-03-10 | Corteva Agriscience Llc | Synergistic mixtures for fungal controls in cereals |
| CN112753706A (en) * | 2020-12-31 | 2021-05-07 | 河北威远生物化工有限公司 | Pyraclostrobin and cyazofamid suspending agent and preparation method thereof |
| CN114642210A (en) * | 2021-04-06 | 2022-06-21 | 山东统防生物科技有限公司 | Suspending agent containing methoxy carbamate and cyazofamid and application thereof |
| CN114642210B (en) * | 2021-04-06 | 2024-05-28 | 山东统防生物科技有限公司 | Suspending agent containing methoxy carbamate and cyazofamid and application thereof |
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Application publication date: 20121010 |