CN104255757A - Compound bactericide - Google Patents
Compound bactericide Download PDFInfo
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- CN104255757A CN104255757A CN201410502677.5A CN201410502677A CN104255757A CN 104255757 A CN104255757 A CN 104255757A CN 201410502677 A CN201410502677 A CN 201410502677A CN 104255757 A CN104255757 A CN 104255757A
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- pyraclostrobin
- fluorobenzene ether
- acid amides
- tomato
- compound bactericide
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Abstract
The invention belongs to the technical field of pesticides and relates to a compound bactericide. The compound bactericide is characterized in that active ingredients comprise fluorobenzene ether amide and pyraclostrobin. The composition can be prepared into suspending agents, dispersible oil suspended agents, water dispersible granules and suspoemulsions, the synergistic effect is obvious, the use amount is reduced, the resistance to drugs is delayed, the lasting period is prolonged, and the compound bactericide is environmentally-friendly.
Description
Technical field
The invention belongs to technical field of pesticide, contain the composite bactericide with synergistic effect of pyraclostrobin and fluorobenzene ether acid amides specifically.
Background technology
Pyraclostrobin (Pyraclostrobin) is novel low toxicity, efficient, wide-spectrum bactericide.This composition is mitochondrial respiratory inhibitor. namely by stoping electro transfer in cytochrome synthesis, thus reach the object of sterilization.This composition has protection, treatment, blade infiltration conduction.Show there is good control efficiency to powdery mildew of cucumber, downy mildew and banana freckle, leaf spot through field control effectiveness test result.This composition shows cucumber, banana safety through field efficacy experiment, has no poisoning and occurs.
Fluorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, and have extraordinary effect to the common epidemic disease of cucumber, tomato, potato, downy mildew, active ingredient is novel, non-resistant.
Early blight of tomato (Tomato Early Blight) has generation in areas such as China northeast, North China, East China, southwest, no matter its main feature occurs in the scab on fruit, blade or stem, have and significantly take turns line, so also referred to as ring spot.All the time, some areas, owing to promoting the tomato variety of viral diseases and not anti-early blight, cause early blight seriously to occur.
Summary of the invention
The object of this invention is to provide a kind of there is synergistic effect and the bactericidal composition of safety and environmental protection for preventing and treating early blight of tomato, compared with existing pesticide control, realize improving drug effect, decreasing pollution, the object that reduces costs.Be specifically related to the composite bactericide of pyraclostrobin and fluorobenzene ether acid amides.
Utilize above-mentioned composite bactericide, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, comprise suspending agent, dispersible oil-suspending agent, water dispersible granules, suspension emulsion.
In above-mentioned composite bactericide, the weight ratio of pyraclostrobin and fluorobenzene ether acid amides is 1:60-60:1.
Above-mentioned composite bactericide has following characteristics: the 1. advanced environmental protection of formulation, and environmental pollution is little; 2. bactericidal action is strong, not easily develops immunity to drugs; 3. two kinds of compositions are composite, have synergistic effect; 4. active ingredient is advanced, non-resistant.
First applicant uses these two kinds of compositions to carry out indoor biometrics experiment, experimental technique and result as follows:
First, after analyzing the action character of two kinds of active ingredients, the raw object surveyed is decided to be sporulation by us, and this bacterium can cause the early blight of tomato.
The test method of indoor biometrics: adopt growth rate method to measure medicament to the inhibitory action of early blight of tomato pathogen mycelial growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the former medicine of 95% pyraclostrobin and the former medicine of 92% fluorobenzene ether acid amides with methyl alcohol to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking tomato early blight bacterium bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Above-mentioned raw survey experiment former medicine used and reagent are all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Indoor biometrics experimental data sees the following form:
Table 1 pyraclostrobin, fluorobenzene ether acid amides and different ratio thereof are to the measurement result of early blight of tomato co-toxicity coefficient
Analyze above-mentioned data, obviously can find out that the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of early blight of tomato is had to the synergistic effect of different proportion when pyraclostrobin and fluorobenzene ether acid amides are composite in varing proportions.Visible, pyraclostrobin and the composite of fluorobenzene ether acid amides become the favourable agents preventing and treating early blight of tomato.
Tested by indoor biometrics, determine pyraclostrobin and fluorobenzene ether acid amides two kinds of active ingredients are composite can good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 36.6% pyraclostrobin fluorobenzene ether acid amides water dispersible granules
Example two, 15.5% pyraclostrobin fluorobenzene ether acid amides dispersibles oil-suspending agent
Example three, 22% pyraclostrobin fluorobenzene ether acid amides suspension emulsion
Example four, 18% pyraclostrobin fluorobenzene ether amide suspending agents
Example five, 18% pyraclostrobin fluorobenzene ether amide suspending agents
Example six, 30% pyraclostrobin fluorobenzene ether amide suspending agents
Example seven, 22% pyraclostrobin fluorobenzene ether acid amides water dispersible granules
Example eight, 31% pyraclostrobin fluorobenzene ether amide suspending agents
Example nine, 30.5% pyraclostrobin fluorobenzene ether amide suspending agents
Select above example to carry out preventing and treating the field trial of early blight of tomato, determine to fill a prescription and prevent and treat the effect of early blight of tomato; Simultaneously by the Contrast on effect with pyraclostrobin and fluorobenzene ether acid amides single dose, verify composite after synergistic effect.Concrete test method is as follows:
The field control effectiveness test of early blight of tomato prevented and treated by 30% pyraclostrobin fluorobenzene ether amide suspending agents and other preparation, carries out comparative trial with 20% pyraclostrobin missible oil and 10% fluorobenzene ether amide suspending agents single dose simultaneously.Test site is Shaanxi Province Yang Ling area, and the time is on September 25th, 2013, and test each process three repetition, community randomized arrangement, each plot area is 30m
2, adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, and the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is: fixed 2 points of each community diagonal, and often some straight ahead determines 20 clumps, and after dispenser, fixed point investigation in the 7th day, 21 days, investigates each community disease and refer to, calculate preventive effect, and carry out the new multipole difference analysis of Deng Kenshi.
The grade scale of disease index:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area, stem stalk there is scab.
Table 3 30% pyraclostrobin fluorobenzene ether amide suspending agents and different agents are to the preventive effect of early blight of tomato
As can be seen from above-mentioned data, pyraclostrobin and fluorobenzene ether acid amides complex preparation after medicine 7 days preventive effects all more than 70%, and pyraclostrobin single dose 7 days preventive effects after medicine are 39.84%, the preventive effect of fluorobenzene ether acid amides single dose is 42.89%, between complex preparation and single dose, preventive effect difference is extremely remarkable, has good synergistic effect after visible two kinds of active ingredients are composite.And after medicine 21 days, all complex preparations have all exceeded 72% to the preventive effect of early blight of tomato, and the lasting period of composite rear preparation extends, more lasting to the control efficiency of early blight of tomato.Complex preparation can well improve drug effect, extends the lasting period, alleviates the amount of labour of peasant, have very high practicality.
Claims (2)
1. a composite bactericide, is characterized in that: active component is made up of fluorobenzene ether acid amides and pyraclostrobin, and the weight ratio of described fluorobenzene ether acid amides and pyraclostrobin is 1:60 ~ 60:1.
2. composite bactericide according to claim 1, is characterized in that: make suspending agent by active component and auxiliary material, dispersible oil-suspending agent, water dispersible granules, suspension emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410502677.5A CN104255757A (en) | 2014-09-26 | 2014-09-26 | Compound bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410502677.5A CN104255757A (en) | 2014-09-26 | 2014-09-26 | Compound bactericide |
Publications (1)
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|---|---|
| CN104255757A true CN104255757A (en) | 2015-01-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201410502677.5A Pending CN104255757A (en) | 2014-09-26 | 2014-09-26 | Compound bactericide |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN107006479A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of bactericidal composition containing SYP-3375 Yu fluorobenzene ether amide |
| CN109418271A (en) * | 2017-09-04 | 2019-03-05 | 浙江省化工研究院有限公司 | A kind of bactericidal composition of fluorine-containing phenylate amide and methoxy acrylic bactericide |
| CN111280170A (en) * | 2018-12-07 | 2020-06-16 | 东莞市东阳光菌阳氢专利农药有限公司 | Bactericidal composition and application thereof |
| CN115211431A (en) * | 2021-04-20 | 2022-10-21 | 东莞市东阳光菌阳氢专利农药有限公司 | Application of bactericidal composition containing fluorobenzene ether amide |
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| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| EP2204094A1 (en) * | 2008-12-29 | 2010-07-07 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants Introduction |
| CN103081933A (en) * | 2012-12-26 | 2013-05-08 | 海利尔药业集团股份有限公司 | Bactericidal composition containing pyraclostrobin and fluxapyroxad |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
| CN103385247A (en) * | 2012-05-10 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fluxapyroxad and strobilurin |
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2014
- 2014-09-26 CN CN201410502677.5A patent/CN104255757A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| CN1205202C (en) * | 1996-07-24 | 2005-06-08 | 拜尔公司 | Carbanilides used as pesticides |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| EP2204094A1 (en) * | 2008-12-29 | 2010-07-07 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants Introduction |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
| CN103385247A (en) * | 2012-05-10 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fluxapyroxad and strobilurin |
| CN103081933A (en) * | 2012-12-26 | 2013-05-08 | 海利尔药业集团股份有限公司 | Bactericidal composition containing pyraclostrobin and fluxapyroxad |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886073A (en) * | 2015-05-21 | 2015-09-09 | 华中师范大学 | Fungicide composite, and preparation and application of fungicide composite |
| CN107006479A (en) * | 2016-01-28 | 2017-08-04 | 响水县智诚知识产权信息服务有限公司 | A kind of bactericidal composition containing SYP-3375 Yu fluorobenzene ether amide |
| CN109418271A (en) * | 2017-09-04 | 2019-03-05 | 浙江省化工研究院有限公司 | A kind of bactericidal composition of fluorine-containing phenylate amide and methoxy acrylic bactericide |
| CN111280170A (en) * | 2018-12-07 | 2020-06-16 | 东莞市东阳光菌阳氢专利农药有限公司 | Bactericidal composition and application thereof |
| CN115211431A (en) * | 2021-04-20 | 2022-10-21 | 东莞市东阳光菌阳氢专利农药有限公司 | Application of bactericidal composition containing fluorobenzene ether amide |
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Application publication date: 20150107 |