CN104542630A - Antibacterial composition containing zinc thiazole and benziothiazolinone - Google Patents
Antibacterial composition containing zinc thiazole and benziothiazolinone Download PDFInfo
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- CN104542630A CN104542630A CN201410829510.XA CN201410829510A CN104542630A CN 104542630 A CN104542630 A CN 104542630A CN 201410829510 A CN201410829510 A CN 201410829510A CN 104542630 A CN104542630 A CN 104542630A
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- benziothiazolinone
- zinc thiazole
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- thiazole
- antibacterial composition
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Abstract
The invention discloses an antibacterial composition containing zinc thiazole and benziothiazolinone. The antibacterial composition comprises effective components of zinc thiazole and benziothiazolinone. The mass ratio of zinc thiazole to benziothiazolinone is (1-15):(15-1). The weight sum of zinc thiazole and benziothiazolinone accounts for 5-91% of the weight of the composition in percentage. According to practical application demands, the dosage form of the antibacterial composition provided by the invention refers to one of missible oil, micro-emulsion, suspending agents, wettable powder and water dispersible granules. The antibacterial composition can be used for preventing and treating fungous and bacterial diseases.
Description
Technical field
The bactericidal composition that the present invention relates to is with zinc thiazole and benziothiazolinone for active ingredient, for preventing and treating the crop pest such as cucumber downy mildew, cucumber bacterial angular leaf spot.
Background technology
The resistance problem of agricultural fungoid and bacterial disease is a global problem, is the emphasis problem that agricultural science and technology worker pays close attention to always.Along with the continuity year in year out of disease chemical control, the increase of Pesticide use amount and not scientifical use agricultural chemicals, germ resistance is day by day serious, and the germ kind producing resistance is on the increase.Meanwhile, the use agricultural chemicals of high strength, causes Practice for Pesticide Residue in Agricultural Products to exceed standard, environmental pollution and the increase of peasant's drug cost etc., is unfavorable for agricultural sustainable development.Therefore, the bactericide agricultural chemicals of efficient, the low toxicity of research and development, environmental protection has positive effect to agricultural sustainable development.
Zinc thiazole, structure forms sterilization by two groups, and one is thiazolyl group, outer to bacterium unrestraint power at plant corpus, but be efficient therapeutic agent in plant corpus, medicament is in the pitted vessel of plant, bacterium is subject to grievous injury, and its cell wall is thinning disintegrates then, causes the death of bacterium; Two is the cation (H on zinc ion and pathogen surface of cell membrane
+, K
+deng) exchange, cause the protein coagulating on germ cell membrane to kill germ.Part zinc ion penetrates in pathogen cell, is combined with some enzyme, and affect its activity, cause dysfunction, germ exhaustion is dead; Zinc thiazole has special efficacy to bacterial diseases such as cucumber bacterial angular leaf spot, citrus bacterial canker disease, bacterial leaf streak of rice.
Benziothiazolinone, English name: benziothiazolinone, benziothiazolinone is organic heterocyclic compounds, very strong inhibitory or killing effect is had to fungi, bacterium class disease, it can destroy germ nuclear structures, the metabolism of interference germ cell, makes its physiological function wad a quilt with cotton disorderly, finally cause death, benziothiazolinone is mainly used in control cucumber downy mildew, pear scab, apple scab, citrus anthracnose, anthracnose of grape etc. all has special efficacy to various bacteria, fungal disease.
The mixture of different pesticide species is the common methods of preventing and treating agriculture disease pest and weed.Being screened by formulation of pesticide, filter out rational formula, can effectively improve actual control efficiency, reduce dosage, reduce costs, delay the drug-fast generation of disease pest and weed, is the important means that agricultural synthesis is administered.The recipe determination of the present inventor to zinc thiazole and benziothiazolinone conducts in-depth research, and finds that zinc thiazole and benziothiazolinone are carried out mixture and had obvious synergistic effect in certain mixed ratio scope to fungus and bacterium, after further study, completes the present invention.
Composition and the application of zinc thiazole and benziothiazolinone there is no report at present.
Summary of the invention
The object of this invention is to provide a kind of efficient, low toxicity and the lasting period long, effectively can prevent and treat the bactericidal composition of cucumber downy mildew, cucumber bacterial angular leaf spot, citrus bacterial canker disease.
The technical solution adopted in the present invention is: a kind of bactericidal composition containing zinc thiazole and benziothiazolinone, active ingredient is zinc thiazole and benziothiazolinone, the weight ratio of zinc thiazole and benziothiazolinone is 1:15 ~ 15:1, zinc thiazole and benziothiazolinone weight summation in the composition percentage by weight are 5% ~ 91%, and all the other are for agriculturally can use and acceptable insecticides adjuvant.
Further: the above-mentioned bactericidal composition containing zinc thiazole and benziothiazolinone according to well known to a person skilled in the art method, can adopt suitable insecticides adjuvant, is configured to the formulation that suspending agent, water dispersible granules, wetting powder etc. are applicable to agriculturally using.
The insecticides adjuvant used in bactericidal composition of the present invention comprises solvent, emulsifier, wetting agent, disintegrant, stabilizing agent, dispersant, thickener, penetrating agent, pH adjusting agent, defoamer, antifreezing agent, carrier etc., and to be of value to active ingredient stable and play the known substance of drug effect in the formulation, be all various compositions that are conventional in pesticidal preparations or permission use, concrete composition and consumption are determined by test according to recipe requirements.
Bactericidal composition of the present invention be applicable to control cucumber downy mildew, cucumber bacterial angular leaf spot, etc. crop pest.
The frequency of administration of bactericidal composition of the present invention and amount of application change with crops, insect, weather condition and have small variations, can by the object using suitable dosage reach effectively control.
Bactericidal composition provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention shows obvious synergistic effect in certain ratio range, and the control efficiency of composition is significantly improved than single dose, reduces the using dosage of agricultural chemicals, decreases the impact of agricultural chemicals on environment, reduces drug cost.
2, the active ingredient mechanism of action of bactericidal composition provided by the invention is different, and the application of composition can delay or overcome the drug-fast generation of germ, increases the service life, is conducive to the comprehensive regulation of disease.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
Preparation method embodiment 1:33% zinc thiazole benziothiazolinone wetting powder.
Mix entering in blender after above-mentioned material in proportion coarse crushing, more namely obtain 33% zinc thiazole benziothiazolinone wetting powder after air-flow crushing.
Preparation method embodiment 2:48% zinc thiazole benziothiazolinone water dispersion granule.
By above-mentioned formula, 48% zinc thiazole benziothiazolinone water dispersion granule is made and is obtained in dry pulverization process, granulation, drying, screening in proportion.
Preparation method embodiment 3:24% zinc thiazole benziothiazolinone suspending agent.
Above-mentioned material is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 24% zinc thiazole benziothiazolinone suspending agent of allotment after high shear mixing.
Assays Example 1: zinc thiazole and benziothiazolinone are to the joint toxicity measuring of bacterium of downy mildew of cucumber.
Test medicine adopts the former medicine of 95% zinc thiazole, the former medicine of 95% benziothiazolinone.
Survey standard method NY/T1156.2-2006 with reference to raw, adopt pastille medium therapy: the liquid 6mL getting each single dose and mixture series concentration, adds in the PDA medium of the 54mL being cooled to 45 DEG C, makes the pastille culture medium flat plate of required final concentration.Then produce 6mm diameter mycelia block from the cultivation bacterium of downy mildew of cucumber colony edge of 7 days, move on each serial pastille medium, mycelia faces down, and each process repeats for 4 times.Be disposed, the constant temperature biochemical cultivation case being placed in 25 ± 1 DEG C is cultivated.
Take out culture medium flat plate after 3 days, measure each process colony diameter by right-angled intersection method, calculate the mycelial growth inhibition rate of each process.Be independent variable x according to the logarithm value of drug concentration (mg/L), with the probit value of corrected mortality for dependent variable y, set up virulence regression equation formula respectively, adopt DPS software to calculate the EC of single dose and each proportioning mixture
50and mixture co-toxicity coefficient.Co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.Actual measurement toxicity index (ATI)=(standard agent EC
50/ reagent agent EC
50) × 100.Theoretical toxicity index (the TTI)=percentage composition of A (in the toxicity index × mixture of the A)+percentage composition of B (in the toxicity index × mixture of B).Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
Table 1, zinc thiazole and benziothiazolinone are to the indoor joint toxicity measuring result of bacterium of downy mildew of cucumber.
| Medicament title and proportioning | EC 50(mg/L) | ATI | TTI | CTC |
| Zinc thiazole | 124.82 | 100.00 | - | - |
| Benziothiazolinone | 5.14 | 2428.40 | - | - |
| Zinc thiazole: benziothiazolinone (15:1) | 33.59 | 371.60 | 245.53 | 151.35 |
| Zinc thiazole: benziothiazolinone (10:1) | 25.74 | 484.93 | 311.67 | 155.59 |
| Zinc thiazole: benziothiazolinone (5:1) | 17.35 | 719.42 | 488.07 | 147.40 |
| Zinc thiazole: benziothiazolinone (1:1) | 7.24 | 1724.03 | 1264.20 | 136.37 |
| Zinc thiazole: benziothiazolinone (1:5) | 4.28 | 2916.36 | 2040.34 | 142.93 |
| Zinc thiazole: benziothiazolinone (1:10) | 3.87 | 3225.32 | 2216.73 | 145.50 |
| Zinc thiazole: benziothiazolinone (1:15) | 3.59 | 3476.88 | 2282.88 | 152.30 |
As can be seen from Table 1, it is 151.35,155.59,147.40,136.37,142.93,145.50,152.30 that zinc thiazole and benziothiazolinone combine bacterium of downy mildew of cucumber CTC value with 15:1,10:1,5:1,1:1,1:5,1:10,1:15 respectively, illustrates that zinc thiazole and benziothiazolinone combination have synergistic effect.
Assays Example 2: the field trial of control cucumber bacterial angular leaf spot.
Test site is positioned at Lao Keng village, Ren Shan town, Huizhou Huidong County, and test period is in May, 2013, adopts spray-on process.Adopt 20% thiazole zincium suspension agent, 3% benziothiazolinone wetting powder medicament in contrast, 5 chemicals treatment are established in test altogether, each process repeats for 4 times, cucumber diseased plant number is investigated before dispenser, within after dispenser 3 days, 7 days, respectively investigate a control efficiency, record diseased plant number, calculate control efficiency, result of the test is as shown in table 2.
Table 2, control cucumber bacterial angular leaf spot result of the test.
As can be seen from Table 2, the effect of 33% zinc thiazole benziothiazolinone wetting powder, 48% zinc thiazole benziothiazolinone water dispersion granule, 24% zinc thiazole benziothiazolinone suspending agent control cucumber bacterial angular leaf spot is better than 20% thiazole zincium suspension agent and 3% benziothiazolinone wetting powder; Illustrate that zinc thiazole and benziothiazolinone composition improve control efficiency, reduce the using dosage of agricultural chemicals, decrease the impact of agricultural chemicals on environment, reduce drug cost.
Claims (5)
1. contain a bactericidal composition for zinc thiazole and benziothiazolinone, it is characterized in that: active ingredient is zinc thiazole and benziothiazolinone, surplus is insecticides adjuvant.
2. a kind of bactericidal composition containing zinc thiazole and benziothiazolinone according to claim 1, is characterized in that: the ratio of weight and number of zinc thiazole and benziothiazolinone is 1:15 ~ 15:1.
3. a kind of bactericidal composition containing zinc thiazole and benziothiazolinone according to claim 1, it is characterized in that, zinc thiazole and benziothiazolinone weight summation in the composition percentage by weight are 5% ~ 91%.
4. a kind of bactericidal composition containing zinc thiazole and benziothiazolinone according to claim 1, is characterized in that: the one being prepared into suspending agent, wetting powder, water dispersible granules when practical application.
5. a kind of bactericidal composition containing zinc thiazole and benziothiazolinone according to claim 1 is to prevent and treat the application in cucumber downy mildew, cucumber bacterial angular leaf spot.
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| CN108077280A (en) * | 2018-02-02 | 2018-05-29 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN110810427A (en) * | 2018-08-10 | 2020-02-21 | 江苏龙灯化学有限公司 | Application of bactericidal composition containing zinc thiazole and benziothiazolinone |
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