CN104957143B - Bactericidal composition containing fluxapyroxad and fludioxonil - Google Patents
Bactericidal composition containing fluxapyroxad and fludioxonil Download PDFInfo
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- CN104957143B CN104957143B CN201510349966.0A CN201510349966A CN104957143B CN 104957143 B CN104957143 B CN 104957143B CN 201510349966 A CN201510349966 A CN 201510349966A CN 104957143 B CN104957143 B CN 104957143B
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Abstract
The invention discloses a kind of bactericidal composition containing fluxapyroxad and fludioxonil, active ingredient is fluxapyroxad and fludioxonil, remaining is insecticides adjuvant, and the weight ratio of fluxapyroxad and fludioxonil is 1：5~5：1, weight percent is 1%~90% in the composition for fluxapyroxad and fludioxonil weight summation；According to practical application needs, bactericidal composition of the present invention can be prepared as one kind in aqueous emulsion, microemulsion, suspending agent, wettable powder, water dispersible granules, for preventing graw mold of tomato, mango anthracnose.The bactericidal composition provided is invented, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and popularization and application have huge economic benefit and social benefit.
Description
Technical field
The present invention relates to a kind of agricultural bactericidal compositions, are using fluxapyroxad and fludioxonil as active ingredient, for preventing
Control graw mold of tomato, mango anthracnose.
Background technology
The resistance problem of agricultural disease is a global problem, is always the emphasis class of agricultural science and technology worker concern
Topic.With the continuity year in year out of disease chemical prevention, the increase of Pesticide use amount and not scientifical use pesticide, germ
Resistance getting worse, the germ type for generating resistance are on the increase.Meanwhile the use pesticide of high intensity, lead to agricultural product pesticide
Exceeded, environmental pollution and the increase of peasant's drug cost etc. are remained, is unfavorable for agricultural sustainable development.Therefore, research and development efficiently,
Low toxicity, environmentally friendly bactericide agricultural chemicals have positive effect to agricultural sustainable development.
Fluxapyroxad, English name：Fluxapyroxad is acid amide fungicides, mainly by inhibiting mitochondria amber
Amber acid esters dehydrogenase hinders tricarboxylic acid cycle, lacks amino acid, sugar, energy is reduced, the division and growth of interference cell, tool
There are protection and therapeutic effect, the powdery mildew, gray mold to gourd, fruit and vegetable class crop are efficient, also have higher work to fruit tree anthracnose
Property.
Fludioxonil, English name：Fludioxonil is protective pyrroles's series bactericidal agent, mainly by inhibiting glucose
The related transfer of phosphorylated, and inhibit the growth of fungal mycelium, germ death is eventually led to, fludioxonil is as foliage fungicide
It uses, to graw mold of tomato special efficacy, also has higher preventive effect to fruit tree anthracnose.
The mixture of different pesticide species is the common methods for preventing agricultural pest.It is screened, filtered out by formulation of pesticide
Rational formula, can effectively improve practical control effect, reduce dosage, reduce cost, delay the generation of pest and disease damage drug resistance,
It is the important means that agricultural synthesis is administered.The present inventor deeply grinds the recipe determination of fluxapyroxad and fludioxonil
Study carefully, it is found that fluxapyroxad and fludioxonil carry out mixture and have apparent synergy to make to a variety of fungies in certain mixed ratio range
With after further study, completing the present invention.
The composition and application of fluxapyroxad and fludioxonil there is no report at present.
Invention content
The technical problem to be solved by the present invention is to provide it is a kind of efficiently, low toxicity and the lasting period it is long, can effectively prevent agriculture fungi
A kind of agricultural bactericidal composition containing fluxapyroxad and fludioxonil of venereal disease evil.
To solve the above problems, the technical solution adopted in the present invention is：It is a kind of containing fluxapyroxad and fludioxonil
Composition, active ingredient are fluxapyroxad and fludioxonil, remaining is the weight ratio of insecticides adjuvant, fluxapyroxad and fludioxonil
It is 1：5~5：1, weight percent is 1%~90% in the composition for fluxapyroxad and fludioxonil weight summation.
According to practical application needs, the present composition can be prepared as according to well known to a person skilled in the art methods
One kind in aqueous emulsion, microemulsion, suspending agent, wettable powder, water dispersible granules.
Also containing the auxiliary agent prepared needed for pesticidal preparations, auxiliary agent is solvent, emulsifier, is total to the agricultural bactericidal composition
Emulsifier, stabilizer, dispersant, thickener, pH adjusting agent, antifoaming agent, antifreezing agent, helps surface agent, transparency temperature model at wetting agent
The mixing of one or more of conditioning agent, filler etc. is enclosed, is known substance, is common various auxiliary agents in pesticidal preparations,
It can be varied from, be not particularly limited according to different situations.
The bactericidal composition of the present invention, for preventing graw mold of tomato, mango anthracnose.
The bactericidal composition of the present invention, generally use spray method use, and can also use and agriculturally apply as needed
Other use technology.
The method have the advantages that：
1st, bactericidal composition provided by the invention shows apparent synergy or summation action in certain ratio range,
Composition is significantly improved to the control effect of germ than single dose, reduces the dosage of pesticide, reduces times for spraying,
Drug cost is reduced, reduces adverse effect of the pesticide to ecological environment.
2nd, bactericidal composition provided by the invention, the combination of two kinds of effective ingredients expand fungicidal spectrum, a drug
The defects of solving the problems, such as multiple diseases, compensating for when single dose uses and limitation.
3rd, bactericidal composition provided by the invention, two kinds of effective ingredient mechanism of action are not quite identical, can overcome long-term
Single use easily generates the shortcomings that resistance, extends the service life of medicament, has important meaning to the comprehensive treatment of germ resistance
Justice.
4th, bactericidal composition provided by the invention, drug effect play rapidly, and the lasting period is long, and use cost is low, easy to use, save
Shi Shengli, popularization and application have huge economic benefit and social benefit.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention more concise, present invention specific examples below
It illustrates, but the present invention is only limitted to absolutely not these embodiments.As described below is only the preferable embodiment of the present invention, is used only for
The description present invention, it is impossible to be interpreted as limiting the scope of the present invention.It should be pointed out that all in the spirit and principles in the present invention
Within all any modification, equivalent and improvement done etc., should all be included in the protection scope of the present invention.Therefore, this hair
The protection domain of bright patent should be determined by the appended claims.
Content described in embodiment is weight percentage.
(1) fluxapyroxad and the preparation method of fludioxonil composite pesticide preparation
Embodiment 1：The bactericidal composition is suspending agent, and each component percentage composition is respectively：
Concrete operation step is：First other auxiliary agents are mixed, shear-mixed is uniform in cutter, then add in effectively into
Point, 2-3h is ground in ball crusher, makes a diameter in 5mm hereinafter, can be prepared by bactericidal composition aqueous suspension formulations of the present invention.
Embodiment 2：The bactericidal composition is aqueous emulsion, and each component percentage composition is respectively：
Concrete operation step is：First active ingredient, solvent, emulsifier are mixed, dissolving becomes uniform oil phase.
Part water and other auxiliary agents are mixed again, dissolving becomes uniform water phase.Then high-speed stirred in a kettle is same
When oil phase added in into water phase, slowly add water to and reach phase inversion point, carry out high speed shear later, and add in remaining water, shearing is about
30min, you can bactericidal composition water and milk agent formulation of the present invention is made.
Embodiment 3：The bactericidal composition is microemulsion, and each component percentage composition is respectively：
Concrete operation step is：Active ingredient with solvent and cosolvent is completely dissolved, then adds other auxiliary agents, is mixed
It closes uniformly, water is eventually adding, after being sufficiently stirred, you can bactericidal composition microemulsion formulation of the present invention is made.
Embodiment 4：The bactericidal composition is wettable powder, and each component percentage composition is respectively：
Concrete operation step is：Active ingredient, other auxiliary agents and filler are mixed, are sufficiently stirred in stirred tank, is passed through
Airslide disintegrating mill is uniformly mixed after crushing, you can bactericidal composition wettable powder formulation of the present invention is made.
Embodiment 5：The bactericidal composition is water dispersible granules, and each component percentage composition is respectively：
Concrete operation step is：Active ingredient, other auxiliary agents and filler are uniformly mixed, with micro jet powder
It is broken, it is added in fluidized-bed granulation dryer after kneading after being granulated, drying, sieve, you can obtained Bactericidal composite of the present invention
Object water-dispersible grain agent formulation.
(2) indoor bioassay embodiment
Embodiment 6：Indoor joint toxicity measuring.
Standard method NY/T1156.2-2006 is surveyed with reference to raw, using pastille culture medium method：Take each single dose and mixture series dense
The liquid 6mL of degree is added in the PDA culture medium of 54mL for being cooled to 45 DEG C, and the pastille culture medium of final concentration is put down required for being made
Plate.Then 6mm diameter mycelia blocks are produced from the object bacteria colony edge of culture 7 days, moved in each serial pastille culture medium, mycelia
Down, each 4 repetitions of processing.It is disposed, is placed in 25 ± 1 DEG C of constant temperature biochemical cultivation case and cultivates.
Culture medium flat plate is taken out after 3 days, each processing colony diameter is measured with crossing method, calculates the mycelia life of each processing
Long inhibiting rate.It is independent variable x according to the logarithm of drug concentration (mg/L), using the probit value of corrected mortality as dependent variable y, point
Virulence regression equation is not established, the EC of single dose and each proportioning mixture is calculated using DPS softwares50And its mixture co-toxicity coefficient.Altogether
Malicious coefficient (CTC) >=120 shows as synergistic effect；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 ＜ co-toxicity coefficients
(CTC) ＜ 120 shows as summation action.Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100。
Theoretical toxicity index (TTI)=(percentage composition of A in toxicity index × mixture of A)+(the hundred of B in toxicity index × mixture of B
Divide content).Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
Table 1, fluxapyroxad and fludioxonil are to the indoor joint toxicity measuring result of graw mold of tomato germ
As can be seen from Table 1, fluxapyroxad and fludioxonil are respectively with 5:1、2:1、1:1、1:2、1:5 combinations are to tomato ash
Mildew germ CTC values are 124.92,136.89,130.56,134.29,131.47, illustrate fluxapyroxad and fludioxonil combination
There is synergistic effect to graw mold of tomato germ.
Table 2, fluxapyroxad and fludioxonil are to the indoor joint toxicity measuring result of mango anthracnose germ
As can be seen from Table 2, fluxapyroxad and fludioxonil are respectively with 5:1、3:1、1:1、1:3、1:5 combinations are to mango charcoal
Subcutaneous ulcer disease germ CTC values are 126.40,124.12,124.98,139.97,127.62, illustrate fluxapyroxad and fludioxonil combination
There is synergistic effect to mango anthracnose germ.
Embodiment 7：Prevent graw mold of tomato field trial.
Test site is located at Huizhou Ma An towns, using spray-on process.Using 25% fluxapyroxad suspending agent,
50% fludioxonil wettable powder sets 7 chemicals treatments altogether as comparison medicament, experiment, 4 repetitions is each handled, before dispenser
The tomato disease number of sheets is investigated, 3 days after dispenser, respectively control effect of investigation, the sick number of sheets of record calculate control effect, experiment knot within 7 days
Fruit is as shown in table 3.
Table 3, fluxapyroxad and fludioxonil combination prevention graw mold of tomato result of the test
As can be seen from Table 3,30% fluxapyroxad fludioxonil suspending agent, 20% fluxapyroxad fludioxonil water and milk
Agent, 20% fluxapyroxad fludioxonil microemulsion, 40% fluxapyroxad fludioxonil wettable powder, 40% fluorine azoles bacterium acyl
The effect of amine fludioxonil water dispersible granules prevention graw mold of tomato illustrates fluxapyroxad and coughs up better than each control single dose processing
Bacterium nitrile compounding can improve control effect, reduce the dosage of pesticide, reduce influence of the pesticide to environment, reduce medication
Cost.
Embodiment 8：Biocontrol of mango anthracnose field trial.
Test site is located at Hainan Province Sanya Nan Bin farms, using spray-on process.Using 25% fluxapyroxad suspending agent,
50% fludioxonil wettable powder sets 7 chemicals treatments altogether as comparison medicament, experiment, 4 repetitions is each handled, before dispenser
The mango disease number of sheets is investigated, 3 days after dispenser, respectively control effect of investigation, the sick number of sheets of record calculate control effect, experiment knot within 7 days
Fruit is as shown in table 4.
Table 4, fluxapyroxad and fludioxonil combination biocontrol of mango anthracnose result of the test
As can be seen from Table 4,30% fluxapyroxad fludioxonil suspending agent, 20% fluxapyroxad fludioxonil water and milk
Agent, 20% fluxapyroxad fludioxonil microemulsion, 40% fluxapyroxad fludioxonil wettable powder, 40% fluorine azoles bacterium acyl
The effect of amine fludioxonil water dispersible granules biocontrol of mango anthracnose illustrates fluxapyroxad and coughs up better than each control single dose processing
Bacterium nitrile compounding can improve control effect, reduce the dosage of pesticide, reduce influence of the pesticide to environment, reduce medication
Cost.
Claims (1)
1. a kind of bactericidal composition containing fluxapyroxad and fludioxonil answering in prevention graw mold of tomato, mango anthracnose
It is fluxapyroxad and fludioxonil with, the bactericidal composition active ingredient, remaining is insecticides adjuvant, fluxapyroxad and is coughed up
The weight ratio of bacterium nitrile is 1：5~5：1, fluxapyroxad and fludioxonil weight summation in the composition weight percent for 1%~
90%。
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| CN117918367A (en) * | 2022-04-07 | 2024-04-26 | 青岛恒宁生物科技有限公司 | Pesticide composition containing bixafen and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103651337A (en) * | 2012-09-24 | 2014-03-26 | 宜德雅(北京)科技有限公司 | Sterilization and synergism suspension agent composition |
| US20150015717A1 (en) * | 2013-07-09 | 2015-01-15 | International Business Machines Corporation | Insight-driven augmented auto-coordination of multiple video streams for centralized processors |
| US20150157017A1 (en) * | 2013-12-06 | 2015-06-11 | Sumitomo Chemical Company, Limited | Method of controlling pests |
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| CN103651337A (en) * | 2012-09-24 | 2014-03-26 | 宜德雅(北京)科技有限公司 | Sterilization and synergism suspension agent composition |
| US20150015717A1 (en) * | 2013-07-09 | 2015-01-15 | International Business Machines Corporation | Insight-driven augmented auto-coordination of multiple video streams for centralized processors |
| US20150157017A1 (en) * | 2013-12-06 | 2015-06-11 | Sumitomo Chemical Company, Limited | Method of controlling pests |
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