CN106172453A - A kind of bactericidal composition and application thereof - Google Patents
A kind of bactericidal composition and application thereof Download PDFInfo
- Publication number
- CN106172453A CN106172453A CN201510208577.6A CN201510208577A CN106172453A CN 106172453 A CN106172453 A CN 106172453A CN 201510208577 A CN201510208577 A CN 201510208577A CN 106172453 A CN106172453 A CN 106172453A
- Authority
- CN
- China
- Prior art keywords
- fluxapyroxad
- zhongshengmycin
- bactericidal composition
- agent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 15
- SXSGXWCSHSVPGB-UHFFFAOYSA-N fluxapyroxad Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1=CC(F)=C(F)C(F)=C1 SXSGXWCSHSVPGB-UHFFFAOYSA-N 0.000 claims abstract description 70
- 239000005788 Fluxapyroxad Substances 0.000 claims abstract description 69
- VMFXMTJCTSYHCF-HHQUSWFZSA-N [(2r,3r,4s,5r)-5-(hexylamino)-4-hydroxy-2-(hydroxymethyl)-6-[(7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl)amino]oxan-3-yl] carbamate Chemical compound CCCCCCN[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)OC1\N=C\1NC(C(=O)NCC2O)C2N/1 VMFXMTJCTSYHCF-HHQUSWFZSA-N 0.000 claims abstract description 66
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 9
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 241000918585 Pythium aphanidermatum Species 0.000 claims description 10
- 239000002552 dosage form Substances 0.000 claims description 7
- 239000000375 suspending agent Substances 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 235000013311 vegetables Nutrition 0.000 claims description 5
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 239000003094 microcapsule Substances 0.000 claims description 4
- 208000035143 Bacterial infection Diseases 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000004530 micro-emulsion Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000004563 wettable powder Substances 0.000 claims description 3
- 241001530056 Athelia rolfsii Species 0.000 claims description 2
- 241000193738 Bacillus anthracis Species 0.000 claims description 2
- 206010039509 Scab Diseases 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 11
- 230000002265 prevention Effects 0.000 abstract description 5
- 238000001228 spectrum Methods 0.000 abstract description 4
- 230000000855 fungicidal effect Effects 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 22
- 230000008569 process Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 244000046052 Phaseolus vulgaris Species 0.000 description 13
- 235000021332 kidney beans Nutrition 0.000 description 13
- 239000003814 drug Substances 0.000 description 11
- 230000008859 change Effects 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 239000000654 additive Substances 0.000 description 9
- 238000013329 compounding Methods 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- 235000002566 Capsicum Nutrition 0.000 description 6
- 239000006002 Pepper Substances 0.000 description 6
- 241000722363 Piper Species 0.000 description 6
- 235000016761 Piper aduncum Nutrition 0.000 description 6
- 235000017804 Piper guineense Nutrition 0.000 description 6
- 235000008184 Piper nigrum Nutrition 0.000 description 6
- 241000589771 Ralstonia solanacearum Species 0.000 description 6
- 241000813090 Rhizoctonia solani Species 0.000 description 6
- 239000000575 pesticide Substances 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical group O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- WHDHEVMINMZADQ-UHFFFAOYSA-N [F].N1C=CC=C1 Chemical class [F].N1C=CC=C1 WHDHEVMINMZADQ-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003337 fertilizer Substances 0.000 description 2
- 229940084434 fungoid Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001228 polyisocyanate Polymers 0.000 description 2
- 239000005056 polyisocyanate Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 230000004763 spore germination Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000004562 water dispersible granule Substances 0.000 description 2
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 208000031968 Cadaver Diseases 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- -1 Zhongshengmycin compound Chemical class 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- BIGPRXCJEDHCLP-UHFFFAOYSA-N ammonium bisulfate Chemical compound [NH4+].OS([O-])(=O)=O BIGPRXCJEDHCLP-UHFFFAOYSA-N 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 208000008025 hordeolum Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000005645 nematicide Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000447 pesticide residue Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000003516 soil conditioner Substances 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 230000009105 vegetative growth Effects 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Abstract
The invention discloses a kind of bactericidal composition, the active ingredient of said composition is made up of fluxapyroxad and Zhongshengmycin, and both mass ratioes are 80:1～1:80.The present composition can be used for preventing and treating the multiple diseases on crops, all has good prevention effect；Have that fungicidal spectrum is wide, dosage is little, the obvious feature of potentiation.
Description
Technical field
The present invention relates to a kind of composition pesticide, particularly relate to a kind of bactericidal composition containing fluxapyroxad
And the application on corps diseases, belong to technical field of pesticide.
Background technology
Fluxapyroxad is that BASF AG finds and produces, by BASF, Meng Shan all with the public affairs such as rural area, Guangxi
The common compound participating in exploitation of department.English name is fluxapyroxad, and No. CAS is 907204-31-3,
Chemical formula is C18H12F5N3O, structural formula is as follows:
Fluxapyroxad is efficient, wide spectrum, holding effect, selectivity are strong, has the Uptake and translocation of excellence, has
Preventive and therapeutic action.Belong to succinate dehydrogenase inhibitors series bactericidal agent, spore-germination, spore can be suppressed
Pipe elongation, mycelial growth and Sporulation, can effectively prevent and treat on corn, Semen sojae atricolor, fruit tree and vegetable multiple
Fungal disease, and under all test doses, the safest to all crops.But fluxapyroxad is current
Production and use cost the highest, and action site is single, is used alone and is easy to produce resistance.
Zhongshengmycin: new bio source bactericide, N-sugar tobramycin antibiotic, this compound can be special from China
Profit 200310103250.X finds.Zhongshengmycin have tag, osmosis, that can kill in soil is thin
Bacterium and fungus, the synthesis of suppression microorganism albumen, cause thalline dead；Hinder fungus spore germination energy
Directly kill spore, cause protoplasm cohesion in hyphal cell, change the form of thread mycelia.
Summary of the invention
It is an object of the invention to provide a kind of synergistic effect substantially, preventing and treating spectrum is wide, the rational compositions of mixture
And application.
For reaching goal of the invention, the technical solution used in the present invention is:
A kind of bactericidal composition, containing effective ingredient fluxapyroxad and Zhongshengmycin in compositions, fluorine azoles bacterium
The mass ratio of amide and Zhongshengmycin is 80:1～1:80, and preferred mass ratio is for 20:1～1:20.
The present composition be particularly suitable for prevent and treat crops disease, described crops include cereal crops,
Legume crop, oil crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit
Crop, root crop, flower crop, medicinal crop, crop, green manure pasture crop.
Described disease includes: gray mold, powdery mildew, anthrax, rust, banded sclerotial blight, early blight, leaf
Mildew, leaf spot, scab, droop, soft rot, bacterial angular leaf spot, bacterial wilt, root rot,
Multiple fungoid and the bacterial diseases such as damping-off, tar spot, shot hole.
Insecticide-applying way can use spraying, pouring root, leaching root, soak seed, gets rid of and execute, spread fertilizer over the fields, ditch spread, spread manuer in holes,
Preferred ditch spread when preventing and treating soil-borne disease, spread manuer in holes, at the soil treatment such as pouring root or leaching root, seed soaking, seed pelleting
Reason.
The present composition can have weeding with other, the compound of bactericidal property is used in mixed way, it is also possible to
Mix with insecticide, nematicide, protective agent, growth regulator, nutrient for plants or soil conditioner and make
With.
The present composition compared with the existing technology, at least can produce following beneficial effect:
1., after two kinds of active components compound in proportion in compositions, there is notable synergistic and lasting effect；
2. field dosage can be greatly decreased, reduce and produce and use cost, effectively reduce environmental pollution and
Pesticide residues, reduce the harm to beneficial organism；
3. expanding fungicidal spectrum: fluxapyroxad can only prevent and treat fungus-caused disease, Zhongshengmycin is excellent
Antibacterial antibacterial, general to antifungal effect, the two is mixed to the fungoid on crops and bacterial disease
The double effect controlled can be played, and effect is notable；
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with embodiment to this
Summary of the invention is described further, but the present invention is limited to absolutely not these examples.Specific embodiment is only used for explaining
The present invention, is not intended to limit the present invention.All made within the spirit and principles in the present invention any amendment,
Equivalent and improvement etc., should be included within the scope of the present invention.Therefore, patent of the present invention
Protection domain should be as the criterion with claims.
The present invention can be prepared as being suitable for the dosage form of agricultural use by known method, and compositions can be according to institute
The various factors such as the crop that need to prevent and treat, local environment condition, prevention and controls, cost accounting, by effective ingredient
Any one dosage form acceptable in pesticides application it is processed into, preferably together with auxiliary agent and carrier (filler)
Dosage form is granule, microcapsule suspending agent, microemulsion, suspending agent, aqueous emulsion, wettable powder, water-dispersible
Granule.Adjuvant used, carrier and process technology use known component.In above-mentioned various dosage forms, effectively
The gross mass percentage composition of composition fluxapyroxad and Zhongshengmycin is 0.5%～85%, such as, when fluorine azoles bacterium
When the weight/mass percentage composition of amide and Zhongshengmycin is respectively 30% and 3%, gross mass percentage composition is 33%.
One, preparation processing formulation Example
Embodiment 1:42% fluxapyroxad Zhongshengmycin suspending agent (fluxapyroxad: Zhongshengmycin=20:1)
Make according to common process, wherein fluxapyroxad 40g, Zhongshengmycin 2g, sodium lignin sulfonate (point
Powder) 4g, sodium lauryl sulphate (wetting agent) 2g, ethylene glycol (antifreeze) 4g, bentonite (increases
Thick dose) 3g, organic silicone (defoamer) 3g, deionized water is mended to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 5%～80%, make the proportioning of used additives make the most therewith
Corresponding adjustment, forms new embodiment.
Embodiment 2:30% fluxapyroxad Zhongshengmycin water dispersible granules (fluxapyroxad: Zhongshengmycin=5:
1)
Make according to common process, wherein fluxapyroxad 25g, Zhongshengmycin 5g, Negel (point
Powder) 5g, sodium lignin sulfonate (dispersant) 7g, sodium lauryl sulphate (wetting agent) 2g, sulphuric acid
Ammonium (disintegrating agent) 5g, precipitated calcium carbonate (filler) complements to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 5%～85%, make the proportioning of used additives make the most therewith
Corresponding adjustment, forms new embodiment.
Embodiment 3:84% fluxapyroxad Zhongshengmycin wettable powder (fluxapyroxad: Zhongshengmycin=20:
1)
Make according to common process, wherein fluxapyroxad 80g, Zhongshengmycin 4g, sodium lauryl sulphate
(wetting agent) 2g, sodium lignin sulfonate (dispersant) 3g, NNO (dispersant) 5g, Kaolin complements to
100g。
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 5%～85%, make the proportioning of used additives make the most therewith
Corresponding adjustment, forms new embodiment.
Embodiment 4:6% fluxapyroxad Zhongshengmycin microemulsion (fluxapyroxad: Zhongshengmycin=1:5)
Making according to common process, wherein fluxapyroxad 1g, Zhongshengmycin 5g, N-Methyl pyrrolidone is (molten
Agent) 10g, isopropanol (solvent) 5g, agriculture No. 500 (emulsifying agent) 5g of breast, agriculture No. 1601 (emulsifyings of breast
Agent) 5g, deionized water complements to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 0.5%～50%, make the proportioning of used additives the most therewith
It is adjusted accordingly, forms new embodiment.
Embodiment 5:10% fluxapyroxad Zhongshengmycin microcapsule suspending agent (fluxapyroxad: Zhongshengmycin=1:
1)
Make according to common process, wherein fluxapyroxad 5g, Zhongshengmycin 5g, Ketohexamethylene (solvent) 1g,
Polyisocyanates (firming agent) 0.4g, ethylene glycol (antifreezing agent) 0.4g, arabic gum (thickening agent) 1g,
Deionized water complements to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 5%～60%, make the proportioning of used additives make the most therewith
Corresponding adjustment, forms new embodiment.
Embodiment 6:10% fluxapyroxad Zhongshengmycin aqueous emulsion (fluxapyroxad: Zhongshengmycin=1:1)
Make according to common process, wherein fluxapyroxad 5g, Zhongshengmycin 5g, calcium dodecyl benzene sulfonate
(emulsifying agent) 2.1g, phenethyl phenol polyethenoxy ether (emulsifying agent) 1.5g, Ketohexamethylene (solvent) 10.1g,
Toluene (solvent) 10.2g, xanthan gum (thickening agent) 0.5g, deionized water complements to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 1%～60%, make the proportioning of used additives make the most therewith
Corresponding adjustment, forms new embodiment.
Embodiment 7:0.55% fluxapyroxad Zhongshengmycin granule (fluxapyroxad: Zhongshengmycin=10:1)
Make according to common process, wherein fluxapyroxad 0.5g, Zhongshengmycin 0.05g, corn starch (point
Dissipate auxiliary agent) 0.5g, Polyethylene Glycol (binding agent) 0.1g, polyvinyl alcohol (slow releasing agent) 0.1g, Kaolin
(filler) complements to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 0.5%～85%, make the proportioning of used additives the most therewith
It is adjusted accordingly, forms new embodiment.
Embodiment 8:5.5% fluxapyroxad Zhongshengmycin microcapsule suspending agent (fluxapyroxad: Zhongshengmycin=1:
10)
Make according to common process, wherein fluxapyroxad 0.5g, Zhongshengmycin 5g, Ketohexamethylene (solvent)
1g, polyisocyanates (firming agent) 0.4g, ethylene glycol (antifreezing agent) 0.4g, arabic gum (thickening agent)
1g, deionized water complements to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 0.5%～60%, make the proportioning of used additives the most therewith
It is adjusted accordingly, forms new embodiment.
Embodiment 9:2.1% fluxapyroxad Zhongshengmycin granule (fluxapyroxad: Zhongshengmycin=1:20)
Make according to common process, wherein fluxapyroxad 0.1g, Zhongshengmycin 2g, corn starch (dispersion
Auxiliary agent) 0.5g, Polyethylene Glycol (binding agent) 0.1g, polyvinyl alcohol (slow releasing agent) 0.1g, Kaolin (is filled out
Material) complement to 100g.
In the present embodiment, the part by weight of fluxapyroxad and Zhongshengmycin can become between 20:1～1:20
Changing, both weight/mass percentage composition can change between 0.5～85%, make the proportioning of used additives make the most therewith
Corresponding adjustment, forms new embodiment.
Two, biological activity determination and field control effectiveness test example
The combination of active principles of different pesticide is made pesticide, is to develop at present and develop novel pesticide and preventing and treating
The agriculturally a kind of effective and quick way of resistance pest and disease damage.After the pestsides synthesis of different cultivars, usual table
Reveal three kinds of type of action: summation action, potentiation and antagonism.But it is specially which kind of effect, nothing
Method is predicted, only just be can determine that by lot of experiments.
Inventor, by substantial amounts of screening test, finds that fluxapyroxad combines multiple diseases with Zhongshengmycin
There is obvious synergistic function.Thus, present example provides above-mentioned bactericidal composition at preventing and treating fresh kidney beans
Damping-off, the application of pepper ralstonia solanacearum, effect is not only the simple addition of two kinds of medicaments, concrete with following
Bioassay example is illustrated.
One) biological activity determination example
Fluxapyroxad joint toxicity measuring to fresh kidney beans rhizoctonia solani compounding with Zhongshengmycin is tested
For examination object: fresh kidney beans rhizoctonia solani (Rhizoctonia solani).
Test use mycelial growth rate method: using the aquesterilisa containing appropriate dimethylbenzene and tween 80 as
Comparison (CK).Take 4mL medicinal liquid to join equipped with the hot culture medium of 36mL (PDA culture medium, 45-50 DEG C)
Conical flask in, after shaking up, pour rapidly diameter 90mm glass culture dish into, band medicine poured into by each culture dish
Culture medium 10mL, each process 4 times repeats, horizontal rest, after cooling flat board.Use diameter 5mm
Card punch cuts bacterium cake from cultivate 3d for examination colony edge, with hordeolum, the one side with mycelia is received band poison
In culture medium, all operations all carries out sterile working at superclean bench.The perseverance of 24 ± 1 DEG C it is placed on after process
In temperature aseptic culture case, camera bellows is cultivated, and uses decussation method to measure the colony diameter of each process respectively after 3d,
Calculate the meansigma methods of colony diameter, mycelial growth inhibition rate.
Mode of application judges to use co-toxicity coefficient (CTC) method.The computing formula of co-toxicity coefficient is as follows:
Actual measurement toxicity index (ATI)=(standard agent LC50/ reagent agent LC50)×100
Percentage composition+B medicament the ATI of A in theoretical toxicity index (TTI)=A medicament ATI × mixture × mixed
The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI)] × 100
When CTC≤80, then compositions shows as antagonism, as 80 ＜ CTC ＜ 120, then and compositions performance
For summation action, when CTC >=120, then compositions shows as potentiation.
Result of the test: joint toxicity measuring to fresh kidney beans rhizoctonia solani after fluxapyroxad and Zhongshengmycin are compounding
The results are shown in Table 1.
Table 1 fluxapyroxad and the compounding joint toxicity measuring result of the test to fresh kidney beans rhizoctonia solani of Zhongshengmycin
| Process | EC50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| Fluxapyroxad | 0.087 | 100.0 | / | / |
| Zhongshengmycin | 20.370 | 0.4 | / | / |
| Fluxapyroxad 80: Zhongshengmycin 1 | 0.072 | 120.8 | 98.8 | 122.34 |
| Fluxapyroxad 40: Zhongshengmycin 1 | 0.057 | 152.6 | 97.6 | 156.43 |
| Fluxapyroxad 20: Zhongshengmycin 1 | 0.042 | 206.7 | 95.3 | 216.94 |
| Fluxapyroxad 10: Zhongshengmycin 1 | 0.048 | 181.3 | 90.9 | 199.29 |
| Fluxapyroxad 5: Zhongshengmycin 1 | 0.054 | 161.1 | 83.4 | 193.17 |
| Fluxapyroxad 1: Zhongshengmycin 1 | 0.087 | 100.0 | 50.2 | 199.15 |
| Fluxapyroxad 1: Zhongshengmycin 5 | 0.271 | 32.1 | 17.0 | 188.59 |
| Fluxapyroxad 1: Zhongshengmycin 10 | 0.482 | 18.0 | 9.5 | 190.42 |
| Fluxapyroxad 1: Zhongshengmycin 20 | 0.867 | 10.0 | 5.2 | 194.14 |
| Fluxapyroxad 1: Zhongshengmycin 40 | 2.485 | 3.5 | 2.9 | 122.60 |
| Fluxapyroxad 1: Zhongshengmycin 80 | 3.689 | 2.4 | 1.7 | 142.38 |
The result of table 1 co-toxicity test shows, fluxapyroxad and Zhongshengmycin compound at 80:1～1:
In the ratio range of 80, the co-toxicity coefficient CTC to fresh kidney beans rhizoctonia solani joint toxicity measuring is all higher than 120, tool
There is potentiation.Especially in the ratio range of 20:1～1:20, CTC is all higher than 180, and potentiation is made
With significantly.
Two) field control effectiveness test example
1, the field control effectiveness test to fresh kidney beans damping-off
Testing and carry out at cities and towns, precipice one, Sanya, Hainan Province vegetable field in November, 2014, this vegetable plot is planted year after year
Fresh kidney beans, fresh kidney beans damping-off occurs serious, and this test uses the method for spray (granule spreads fertilizer over the fields), choosing
The fresh kidney beans taken grow basically identical (7d after plantation), and 10d investigates damping-off incidence (medicine after medicine
Before do not fall ill, do not investigate state of an illness radix), every community diagonal 5 sampling, every some investigation 5 strains, record adjust
Looking into total strain number, diseased plant number, calculate preventive effect, computing formula is as follows:
From table 2, data can draw, various dosage form potentiations after fluxapyroxad is compounding with Zhongshengmycin
Substantially；10d after dispenser, each compound drug is also significantly better than comparison single dose to the prevention effect of fresh kidney beans damping-off.
Table 2 fluxapyroxad field control effect to fresh kidney beans damping-off compounding with Zhongshengmycin
2, the field control effectiveness test to pepper ralstonia solanacearum
Testing and carry out at Shouguang City of Shandong Province one green house of vegetables in December, 2014, by pouring root, (granule spreads
Execute) method, the chili growth chosen is basically identical, is in vegetative growth phase, and former years, bacterial wilt occurred
Heavier, 60d investigation pepper ralstonia solanacearum incidence (not falling ill before medicine, do not investigate state of an illness radix) after medicine,
Every community 5 samplings of diagonal, every some investigation 5 strains, the record total strain number of investigation, diseased plant number, calculate preventive effect,
Computing formula is as follows:
From table 3, data can draw, various dosage form potentiations after fluxapyroxad is compounding with Zhongshengmycin
Substantially；60d after dispenser, each compound drug is also significantly better than single dose to the prevention effect of pepper ralstonia solanacearum.
Table 3 fluxapyroxad field control effect to pepper ralstonia solanacearum compounding with Zhongshengmycin
Compounding to fresh kidney beans damping-off, the field control effectiveness test of pepper ralstonia solanacearum from fluxapyroxad and Zhongshengmycin
Result is seen, each compound drug all has good prevention effect to damping-off and bacterial wilt, and preventive effect is significantly better than right
According to single dose.Illustrating to compound and have potentiation, the lasting period extends, and can reduce dosage and spraying times,
Delay Drug resistance to produce, cost accounting can be reduced simultaneously.
These are only presently preferred embodiments of the present invention, not in order to limit the present invention, all the present invention's
Any amendment, equivalent and the improvement etc. made within spirit and principle, should be included in the guarantor of the present invention
Within the scope of protecting.
Claims (5)
1. a bactericidal composition, it is characterised in that: in compositions containing effective ingredient fluxapyroxad and in
Raw rhzomorph, both mass ratioes are 80:1～1:80.
Bactericidal composition the most according to claim 1, it is characterised in that: effective ingredient fluxapyroxad
It is 20:1～1:20 with the mass ratio of Zhongshengmycin.
Bactericidal composition the most according to claim 1 and 2, it is characterised in that: compositions can be made
Dosage form have granule, microcapsule suspending agent, microemulsion, aqueous emulsion, suspending agent, wettable powder, moisture
Shot agent.
Bactericidal composition the most according to claim 3, it is characterised in that: effective ingredient in compositions
Gross mass percentage composition is 0.5%～85%.
5. bactericidal composition described in claim 1 is for preventing and treating gray mold on vegetable, fruit tree, flowers, white
Powder disease, anthrax, rust, banded sclerotial blight, early blight, leaf mold, leaf spot, scab, droop,
Soft rot, bacterial angular leaf spot, bacterial wilt, root rot, damping-off, tar spot, shot hole etc. are multiple very
Bacterium property and the purposes of bacterial disease.
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