CN106857599A - A kind of bactericidal composition containing pyraclostrobin and folpet and its application - Google Patents
A kind of bactericidal composition containing pyraclostrobin and folpet and its application Download PDFInfo
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- CN106857599A CN106857599A CN201710284538.3A CN201710284538A CN106857599A CN 106857599 A CN106857599 A CN 106857599A CN 201710284538 A CN201710284538 A CN 201710284538A CN 106857599 A CN106857599 A CN 106857599A
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- CN
- China
- Prior art keywords
- pyraclostrobin
- folpet
- bactericidal composition
- apple
- leaf spot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 239000005869 Pyraclostrobin Substances 0.000 title claims abstract description 32
- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 239000005789 Folpet Substances 0.000 title claims abstract description 28
- HKIOYBQGHSTUDB-UHFFFAOYSA-N folpet Chemical compound C1=CC=C2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C2=C1 HKIOYBQGHSTUDB-UHFFFAOYSA-N 0.000 title claims abstract description 26
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 14
- 201000010099 disease Diseases 0.000 claims abstract description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 16
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 10
- 239000000575 pesticide Substances 0.000 claims abstract description 10
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 9
- 241000223600 Alternaria Species 0.000 claims abstract description 8
- 241001661269 Marssonina Species 0.000 claims abstract description 7
- 239000003905 agrochemical Substances 0.000 claims abstract description 6
- 244000299906 Cucumis sativus var. sativus Species 0.000 claims abstract 2
- 238000009472 formulation Methods 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000003641 microbiacidal effect Effects 0.000 claims description 8
- 229940124561 microbicide Drugs 0.000 claims description 8
- 239000002855 microbicide agent Substances 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 5
- 239000004562 water dispersible granule Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 9
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 239000012752 auxiliary agent Substances 0.000 abstract description 3
- 239000003899 bactericide agent Substances 0.000 abstract description 3
- 235000011430 Malus pumila Nutrition 0.000 description 13
- 235000015103 Malus silvestris Nutrition 0.000 description 13
- 239000003814 drug Substances 0.000 description 13
- 230000001988 toxicity Effects 0.000 description 12
- 231100000419 toxicity Toxicity 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 238000012360 testing method Methods 0.000 description 8
- 240000008067 Cucumis sativus Species 0.000 description 7
- 239000000306 component Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 241000233866 Fungi Species 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 231100000820 toxicity test Toxicity 0.000 description 4
- 102100025287 Cytochrome b Human genes 0.000 description 3
- 108010075028 Cytochromes b Proteins 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- -1 folpet compound Chemical class 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 240000008790 Musa x paradisiaca Species 0.000 description 2
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 2
- 241000233654 Oomycetes Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 230000002407 ATP formation Effects 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241001480649 Colletotrichum destructivum Species 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 102000019265 Cytochrome c1 Human genes 0.000 description 1
- 108010007528 Cytochromes c1 Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 241000233622 Phytophthora infestans Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 210000002726 cyst fluid Anatomy 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- XUZHLZDRCCUWEV-UHFFFAOYSA-N formaldehyde;methyl naphthalene-1-sulfonate Chemical compound O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 XUZHLZDRCCUWEV-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- BSDQITJYKQHXQR-UHFFFAOYSA-N methyl prop-2-eneperoxoate Chemical class COOC(=O)C=C BSDQITJYKQHXQR-UHFFFAOYSA-N 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of bactericidal composition comprising pyraclostrobin and folpet, two kinds of weight ratios of active ingredient are 1 30:1 30, the weight percentage of active ingredient is 5 90%, preferably 40 65% in bactericide, and remaining is the auxiliary agent and carrier of permission in agricultural chemicals.Composition of the invention has obvious synergistic effect, can reduce Pesticide use amount, and environmentally friendly safety can be used for the preventing and treating of various crop disease such as cucumber downy mildew, alternaria leaf spot of apple, apple marssonina leaf spot etc..
Description
Technical field
The present invention relates to field of pesticide chemistry, it is specifically a kind of with pyraclostrobin and folpet as chief active into
The biological bactericide composition divided and its application.
Background technology
Pyraclostrobin, English name Pyraclostrobin is methoxy acrylate class broad-spectrum germicide, with guarantor
Shield, treatment and osmosis, its wide sterilization spectrum, have good prevention effect for various crop disease.It passes through to suppress disease
The mitochondrial respiratory of bacterium and work, the mechanism of action by with pathogen mitochondrial inner membrane outer wall on cytochrome b c1 be combined
The Qo centers site of cytochrome b combines in body, suppresses the electron transmission between cytochrome b and cytochrome C1, hinders ATP's
Synthesis, has cut off the energy circulation of fungi and antibacterial activity has been presented；Category new-type wide-spectrum bactericide, to fungi (sac fungus, load
Bacterium, Fungi Imperfecti, oomycetes) disease late blight, gray mold, powdery mildew, downy mildew, scab, leaf spot, sclerotiniose, anthracnose etc.
There is the antibacterial activity of brilliance, crop immunity can be significantly improved, promote plant growth, be mainly used in banana, apple, grape etc.
On fruit tree crop, to the disease effect is significant such as banana freckle, alternaria leaf spot of apple.But drug cost is high, single company all the year round
Continuous medication, has generated the obvious resistance to the action of a drug.Therefore, it is badly in need of pyraclostrobin and other efficient germicides are carried out into compounding opening
New composition and environmentally friendly formulation is sent, so as to delay its drug-fast development, while preferably environmental protection.
Folpet, English name folpet is organosulfureous fungicide, is protective fungicide, is mainly used in preventing and treating grain and oil
The multiple diseases such as crop, vegetables, fruit tree, flowers, have stimulation to growth and development of plants, can prevent and treat rice blast, rice banded sclerotial blight
Disease, wheat rust, head blight, oilseed rape downy mildew, leaf spot of peanut, the late blight of potato, tomato early blight, anthracnose of tobacco,
Apple anthracnose etc.；Can be used with the antifungal mixture of absorbability, delay drug-fast development.
Facts have proved that resistance problem easily occurs in the long-term use of chemical pesticide single dose, cause consumption to continue to increase, risk
Increase, be unfavorable for Environment Ecological Safe.The pesticide active ingredient of different types of structure is compounded, is to solve agricultural chemicals list at present
Cost and a kind of effective means the problems such as resistance in agent application process.Compound synergic is formulated well, can improve actual preventing and treating
Effect, reduces the usage amount of agricultural chemicals, contributes to the generation of delaying drug resistance, is the important means of scientific prevention and cure pest and disease damage.Exist at present
The relevant report for also being compounded without pyraclostrobin and folpet both at home and abroad.
The content of the invention
The present invention provides a kind of microbicide compositions with synergistic function.Said composition have bactericidal effect it is good,
The features such as reducing the usage amount and access times of chemical pesticide, be not likely to produce the resistance to the action of a drug.
Another object of the present invention is to provide above-mentioned microbicide compositions for preventing and treating the application of crop disease.
What the present invention was accomplished by the following way：
A kind of microbicide compositions containing pyraclostrobin and folpet, it is characterised in that contain pyraclostrobin and sterilizing
The weight ratio of pellet, pyraclostrobin and folpet is 1-30 ﹕ 1-30, weight is more excellent than further than preferred 1-15 ﹕ 1-15, weight
Elect 1-5 ﹕ 1-5 as.
Active component can be configured to various conventional formulations with various auxiliary combinations of the prior art, pyraclostrobin and go out
The red gross weight in the formulation of bacterium accounts for the 5%~90% of the whole quality of the pharmaceutical preparations, preferably 40%~65%.The bright composition pesticide of this law
Formulation be preferably missible oil, suspending agent, water dispersible granules, aqueous emulsion, wettable powder, microemulsion.
The auxiliary agent includes emulsifying agent, dispersant, wetting agent, bleeding agent, preservative, antifreezing agent, defoamer, solvent, fills out
Material etc., can select usual auxiliaries of the prior art
Confirmed through applicant's many experiments, pyraclostrobin and folpet microbicide compositions have good bactericidal effect and hold
The effect phase, mainly prevent and treat by Ascomycetes, Basidiomycetes, Oomycete and the fungus-caused crop disease of Fungi Imperfecti, especially exist
The aspect excellent effects such as preventing and treating cucumber downy mildew, alternaria leaf spot of apple, apple marssonina leaf spot.
Microbicide compositions of the invention have beneficial effect following prominent compared with prior art：
1st, pyraclostrobin and the mutual mixture of folpet will not produce conflict, and substantially, preventive effect is higher than single dose, lasting period for synergistic effect
It is long.2nd, Pesticide use amount can be greatly reduced, reduces cost reduces residual quantity of the agricultural chemicals on crops, mitigates environmental pollution；
3rd, fungicidal spectrum is expanded, to the various crop disease such as big spot of cucumber downy mildew, alternaria leaf spot of apple, apple marssonina leaf spot, corn
Disease etc. has activity higher.
Specific embodiment
Biologicall test example one：Pyraclostrobin and folpet compound the toxicity test to alternaria leaf spot of apple germ
Subjects：Alternaria leaf spot of apple germ
After weighing a certain amount of pyraclostrobin and folpet original medicinal solvent dilution, Tween-80 and a certain amount of is added respectively
Aqua sterilisa is made into mother liquor.On the basis of mother liquor, by trial test result, dilution of more than 5 series for examination concentration is prepared, often
Individual concentration sets more than 4 and repeats.Respectively according to pyraclostrobin and folpet preset blending ratio, mother liquor is diluted to aqua sterilisa suitable
Work as series concentration.
Experiment uses mycelial growth rate method.Made with the sterile water solution containing appropriate dimethyl sulfoxide (DMSO) and Tween-80
Control (CK).2ml liquids are taken to be added in the conical flask equipped with the hot culture mediums of 38ml (PDA culture medium, 45-50 DEG C), after shaking up,
Rapid to pour into diameter 90mm glass culture dish, each culture dish pours into band medicine culture medium 13ml, each three repetitions for the treatment of, level
Stand, flat board is made after cooling.The bacteria cake one of diameter 0.4cm is accessed per ware.All operations carry out nothing in superclean bench
Bacterium operates.Culture in 26 ± 1 DEG C of constant temperature sterile culture case is placed on after treatment, is taken out after 3d.Surveyed respectively using crossing method
The colony diameter of each treatment is measured, the average value of colony diameter, mycelial growth is calculated and is suppressed virulence regression equation and EC50.Again according to grandson
Yun Peifa calculates co-toxicity coefficient (CTC).As CTC ＜ 80, then composition shows as antagonism, as 80 ＜ CTC ＜ 120, then group
Compound shows as summation action, and as CTC ＞ 120, then composition shows as synergistic effect.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture in the percentage composition+B medicament toxicity index × mixture of A
The percentage composition of B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
Toxicity test the results are shown in Table 1.
Result of the test shows that pyraclostrobin and folpet have synergistic effect to alternaria leaf spot of apple germ, proportioning
In 30-1：When between 1-30, co-toxicity coefficient is all more than 120；
Biologicall test example two：Pyraclostrobin and folpet compound the toxicity test to cucumber downy mildew
Subjects：Bacterium of downy mildew of cucumber
Experiment is determined using pot-culture method.The consistent two panels leaf period cucumber seedling of growth is chosen, each treatment is from 15 basins for examination melon
Seedling, numbers standby.Sprayed under 50PSI pressure with Potter spray towers, per basin 5mL.Each medicament sets 6 concentration gradients,
It is blank with the treatment for spraying equivalent clear water.The downy mildew leaf for picking up from field is taken, 10 DEG C or so of distillation is dipped with writing brush
The sporangium at the lower back side of washing, it is 3 × 10 to be made into concentration5The sporangia suspension of individual/mL.Connect in spraying after chemicals treatment 24h
Spore cyst fluid is planted, cucumber seedling is placed in growth cabinet (relative humidity 100%, 15~20 DEG C of temperature) culture, 24h after inoculation
15~24 DEG C of keeping temperature, the moisturizing of relative humidity 90% or so afterwards induces, and is investigated after 10d and records incidence, calculates the state of an illness and refers to
Number and prevention effect.Concentration EC in suppressing is calculated with least square method50, then calculate co-toxicity coefficient (CTC) according to the abundant methods of Sun Yun.When
CTC ＜ 80, then composition show as antagonism, as 80 ＜ CTC ＜ 120, then composition shows as summation action, as CTC ＞
120, then composition show as synergistic effect.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture in the percentage composition+B medicament toxicity index × mixture of A
The percentage composition of B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
Toxicity test the results are shown in Table 2.
Result of the test shows that pyraclostrobin and folpet have synergistic effect to cucumber downy mildew, match in 30-1：1-
When between 30, co-toxicity coefficient is all more than 120；Proportioning is in 5-1：When between 1-5, co-toxicity coefficient is all more than 150.
Two kinds of reactive compounds can be processed into any one formulation of permission, preferably missible oil, suspending agent, wettable powder, water
Dispersible granule, aqueous emulsion, microemulsion.The preparation that two kinds of active ingredient is processed into is illustrated with specific embodiment below, but should
The preparation that two kinds of active components can be processed is not limited only to set forth below.
Embodiment 1：50% suspending agent
Pyraclostrobin 25%, folpet 25%, methyl naphthalene sulfonate formaldehyde condensate 8%, xanthans 2%, bentonite 3%,
Agriculture breast 500# 5%, isopropanol 5%, water complement to 100%.By each components such as active component, dispersant, wetting agent and water by matching somebody with somebody
The ratio of side is well mixed, and 50% suspending agent is obtained after ground and/or high speed shear.
Embodiment 2：45% wettable powder
Pyraclostrobin 5%, folpet 40%, lauryl sodium sulfate 3%, sodium lignin sulfonate 6%, White Carbon black 8%, height
Ridge soil complements to 100%.Active component, various auxiliary agents and filler etc. are sufficiently mixed in the ratio of formula, through ultrafine crusher
After crushing, 45% wettable powder is obtained final product.
Embodiment 3：80% water dispersible granules
Pyraclostrobin 20%, folpet 60%, Negel 3%, sodium lignin sulfonate 4%, lauryl sodium sulfate
2%th, ammonium sulfate 5%, precipitated calcium carbonate complements to 100%.By active component, dispersant, wetting agent, disintegrant and filler by matching somebody with somebody
The ratio of side is well mixed, and through air-flow crushing into wettable powder, adds a certain amount of water mixing extruding and makes material, through drying
80% water-dispersible granules are obtained after screening.
Embodiment 4：39% microemulsion
Pyraclostrobin 30%, folpet 9%, 1-METHYLPYRROLIDONE 10%, isopropanol 15%, agriculture breast 500#5%, agriculture breast
1601# 5%, water complements to 100%.Active compound, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；By water solubility
Component and water are mixed to prepare water phase；Under high velocity agitation, it is oil phase is mixed with water, 39% microemulsion is obtained.
Field information embodiment one：
Subjects：Apple marssonina leaf spot
According to the Institute for the Control of Agrochemicals of the Ministry of Agriculture,PRC edit "《Pesticide field efficacy medicine test criterion（Two）》124th part：Design the application
The field control effectiveness test of preparation and Comparative formulation to apple marssonina leaf spot.
Experiment sets 7 treatment altogether, often processes 4 repetitions, and 28 cells are set altogether, per 4 strain trees of cell.Each cell is random
Arrangement.Spraying equipment uses the type high pressure power driven sprayer of workers and peasants 26, with whole branch blade in tree crown it is uniform medicine, drip for
Only.Its prevention effect was investigated using blade staging in 14 days after medicine.
Table of field test results is bright：It is good to the prevention effect of apple marssonina leaf spot disease that pyraclostrobin and folpet are applied in combination
In single dose, with synergistic effect.And produced without poisoning, performance safety.
Further narration has been done to the present invention above in conjunction with embodiment, but the present invention is not limited to above-mentioned implementation method,
In the ken that one skilled in the relevant art possesses, can also be made on the premise of present inventive concept is not departed from
Various change.
Claims (8)
1. a kind of microbicide compositions containing pyraclostrobin and folpet, it is characterised in that contain pyraclostrobin and sterilizing
The weight ratio of pellet, pyraclostrobin and folpet is 1-30 ﹕ 1-30.
2. described microbicide compositions are required according to right 1, it is characterised in that the weight ratio of pyraclostrobin and folpet is
1-15 ﹕ 1-15.
3. described microbicide compositions are required according to right 1, it is characterised in that the weight ratio of pyraclostrobin and folpet is
1-5 ﹕ 1-5.
4. the bactericidal composition according to any one of claim 1-3, it is characterised in that：Can be prepared into what is received on agricultural chemicals
Preparation, pyraclostrobin and folpet gross weight in the formulation account for the 5%~90% of the whole quality of the pharmaceutical preparations.
5. bactericidal composition according to claim 4, it is characterised in that：Pyraclostrobin and folpet in the formulation total
Weight accounts for the 40%~65% of the whole quality of the pharmaceutical preparations.
6. composition pesticide according to claim 4, it is characterised in that：The formulation of the composition pesticide is missible oil, suspends
Agent, water dispersible granules, aqueous emulsion, wettable powder, microemulsion.
7. the bactericidal composition according to any one of claim 1-6 is used for the purposes of controlling plant diseases.
8. the bactericidal composition according to any one of claim 7 is used for the purposes of controlling plant diseases, the disease bag
Include cucumber downy mildew, alternaria leaf spot of apple, apple marssonina leaf spot.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710284538.3A CN106857599A (en) | 2017-04-27 | 2017-04-27 | A kind of bactericidal composition containing pyraclostrobin and folpet and its application |
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| CN201710284538.3A CN106857599A (en) | 2017-04-27 | 2017-04-27 | A kind of bactericidal composition containing pyraclostrobin and folpet and its application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107242242A (en) * | 2017-08-02 | 2017-10-13 | 广东广康生化科技股份有限公司 | Bactericidal composition comprising folpet and prothioconazoles |
| CN108432759A (en) * | 2018-03-27 | 2018-08-24 | 南京农业大学 | A kind of composition for preventing plant disease caused by sickle-like bacteria |
| WO2023002475A1 (en) * | 2021-07-17 | 2023-01-26 | Adama Makhteshim Ltd. | Aqueous fungicide mixture formulation |
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| CN1216441A (en) * | 1996-04-26 | 1999-05-12 | 巴斯福股份公司 | fungicidal mixture |
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2017
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| CN1216441A (en) * | 1996-04-26 | 1999-05-12 | 巴斯福股份公司 | fungicidal mixture |
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| ANDREA LUBBE等: "Effects of fungicides on galanthamine and metabolite profiles in Narcissus bulbs", 《PLANT PHYSIOLOGY AND BIOCHEMISTRY》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107242242A (en) * | 2017-08-02 | 2017-10-13 | 广东广康生化科技股份有限公司 | Bactericidal composition comprising folpet and prothioconazoles |
| CN108432759A (en) * | 2018-03-27 | 2018-08-24 | 南京农业大学 | A kind of composition for preventing plant disease caused by sickle-like bacteria |
| CN108432759B (en) * | 2018-03-27 | 2021-09-14 | 南京农业大学 | Composition for preventing and treating plant diseases caused by fusarium |
| WO2023002475A1 (en) * | 2021-07-17 | 2023-01-26 | Adama Makhteshim Ltd. | Aqueous fungicide mixture formulation |
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Application publication date: 20170620 |