CN106172453B - A kind of bactericidal composition and its application - Google Patents
A kind of bactericidal composition and its application Download PDFInfo
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- CN106172453B CN106172453B CN201510208577.6A CN201510208577A CN106172453B CN 106172453 B CN106172453 B CN 106172453B CN 201510208577 A CN201510208577 A CN 201510208577A CN 106172453 B CN106172453 B CN 106172453B
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- Prior art keywords
- zhongshengmycin
- fluxapyroxad
- bactericidal composition
- composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 13
- SXSGXWCSHSVPGB-UHFFFAOYSA-N fluxapyroxad Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1=CC(F)=C(F)C(F)=C1 SXSGXWCSHSVPGB-UHFFFAOYSA-N 0.000 claims abstract description 72
- 239000005788 Fluxapyroxad Substances 0.000 claims abstract description 70
- VMFXMTJCTSYHCF-HHQUSWFZSA-N [(2r,3r,4s,5r)-5-(hexylamino)-4-hydroxy-2-(hydroxymethyl)-6-[(7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl)amino]oxan-3-yl] carbamate Chemical compound CCCCCCN[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)OC1\N=C\1NC(C(=O)NCC2O)C2N/1 VMFXMTJCTSYHCF-HHQUSWFZSA-N 0.000 claims abstract description 67
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 9
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 241000918585 Pythium aphanidermatum Species 0.000 claims description 10
- 239000002552 dosage form Substances 0.000 claims description 7
- 239000000375 suspending agent Substances 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 239000003094 microcapsule Substances 0.000 claims description 4
- 235000013311 vegetables Nutrition 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000004530 micro-emulsion Substances 0.000 claims description 3
- 239000004562 water dispersible granule Substances 0.000 claims description 3
- 239000004563 wettable powder Substances 0.000 claims description 3
- 241001530056 Athelia rolfsii Species 0.000 claims description 2
- 241000221785 Erysiphales Species 0.000 claims description 2
- 206010039509 Scab Diseases 0.000 claims description 2
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- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
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- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 230000008859 change Effects 0.000 description 18
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- 239000003814 drug Substances 0.000 description 13
- 235000021332 kidney beans Nutrition 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
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- 241000894006 Bacteria Species 0.000 description 5
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- 239000006002 Pepper Substances 0.000 description 5
- 241000722363 Piper Species 0.000 description 5
- 235000016761 Piper aduncum Nutrition 0.000 description 5
- 235000017804 Piper guineense Nutrition 0.000 description 5
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- 241000589771 Ralstonia solanacearum Species 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
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- 239000008187 granular material Substances 0.000 description 5
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- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
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- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
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- 238000005516 engineering process Methods 0.000 description 3
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- 239000003337 fertilizer Substances 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
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- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940099112 cornstarch Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 230000004763 spore germination Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 208000031968 Cadaver Diseases 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 240000008384 Capsicum annuum var. annuum Species 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000726221 Gemma Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- -1 Zhongshengmycin compound Chemical class 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
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- 239000007884 disintegrant Substances 0.000 description 1
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- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229940084434 fungoid Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000005645 nematicide Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001228 polyisocyanate Polymers 0.000 description 1
- 239000005056 polyisocyanate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000003516 soil conditioner Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
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- 238000003892 spreading Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The invention discloses a kind of bactericidal composition, the active ingredient of the composition is made of fluxapyroxad and Zhongshengmycin, and the mass ratio of the two is 80：1~1：80.The multiple diseases that the present composition can be used on prevention crops, there is good control effect；Have the characteristics that wide sterilization spectrum, dosage are small, synergistic effect is apparent.
Description
Technical field
The present invention relates to a kind of composition pesticide more particularly to a kind of bactericidal composition containing fluxapyroxad and its
Application on corps diseases, belongs to technical field of pesticide.
Background technology
Fluxapyroxad finds and produces for BASF AG, common by companies such as BASF, Monsanto and Guangxi rural areas
Participate in the compound of exploitation.English name is fluxapyroxad, and No. CAS is 907204-31-3, chemical formula C18H12F5N3O,
Structural formula is as follows：
Fluxapyroxad efficiently, wide spectrum, holding effect, selectivity it is strong, there is excellent uptake and translocation, possess prevention and treatment
Effect.Belong to succinate dehydrogenase inhibitors series bactericidal agent, spore-germination, the elongation of gemma pipe, mycelial growth and spore can be inhibited
Son is formed, and can effectively prevent a variety of fungal diseases on cereal, soybean, fruit tree and vegetables, and under all test doses, to all
Crop is very safe.But fluxapyroxad it is current production and application cost it is higher, and action site is single, individually makes
Be easy to generate resistance.
Zhongshengmycin：New bio source bactericide, N- glycoside antibiotic, the compound can be from Chinese patents
It is found in 200310103250.X.Zhongshengmycin have tag, osmosis, the bacterium and fungi in soil can be killed, inhibit
The synthesis of microorganism albumen causes thalline dead；Fungus spore germination is hindered simultaneously directly to kill spore, causes hyphal cell
Interior plasm cohesion changes the form of Filamentous mycelia.
Invention content
The purpose of the present invention is to provide a kind of synergistic effect is apparent, prevention spectrum is wide, the rational composition of mixture and its should
With.
To reach goal of the invention, the technical solution adopted by the present invention is：
A kind of bactericidal composition, containing active ingredient fluxapyroxad and Zhongshengmycin in composition, fluxapyroxad with
The mass ratio of Zhongshengmycin is 80：1~1：80, preferred mass ratio is 20：1~1：20.
Disease of the present composition particularly suitable for preventing crops, the crops include cereal crops, beans
Crop, oil crops, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, root crop, flower
Grass crop, medicinal crop, crop, green manure pasture crop.
The disease includes：Gray mold, powdery mildew, anthracnose, rust, banded sclerotial blight, early blight, leaf mold, leaf spot,
Scab, droop, soft rot, bacterial angular leaf spot, bacterial wilt, root rot, damping-off, tar spot, shot hole etc. are a variety of true
Bacterium property and bacterial disease.
Insecticide-applying way may be used spraying, pouring root, leaching root, soak seed, gets rid of and apply, spread fertilizer over the fields, ditch spread, spreading manuer in holes, and prevent soil-borne disease
Preferred ditch spread during evil is spreaded manuer in holes, the soil treatments such as pouring root or leaching root, seed soaking, seed pelleting processing.
The present composition can be used in mixed way with other compounds with weeding, bactericidal property, can also be with desinsection
Agent, nematicide, protective agent, growth regulator, nutrient for plants or soil conditioner are used in mixed way.
The present composition compared with the existing technology, can at least generate following advantageous effect：
After 1. two kinds of active components compound in proportion in composition, there is notable synergistic and lasting effect；
2. field dosage can be greatly decreased, production and application cost is reduced, environmental pollution is effectively reduced and pesticide is residual
It stays, reduces the harm to beneficial organism；
3. expand fungicidal spectrum：Fluxapyroxad can only prevent fungus-caused disease, and Zhongshengmycin is excellent bacterium
Fungicide, general to antifungal effect, the two is used with can play the simultaneous work controlled to the fungoid on crops and bacterial disease
With, and significant effect；
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiment in the present invention
Appearance is described further, but the present invention is limited to absolutely not these examples.Specific embodiment is only used for explaining the present invention, is not used to limit
The fixed present invention.Any modifications, equivalent replacements and improvementsmade within the spirit and principles of the invention, etc., should be included in
Within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
The present invention can be prepared into the dosage form of suitable agricultural use by known method, and composition can be according to required prevention
The various factors such as crop, local environment condition, control method, cost accounting, by active ingredient and auxiliary agent and carrier (filler)
It is processed into any one acceptable dosage form in pesticides application together, preferred dosage form is granule, microcapsule suspending agent, micro emulsion
Agent, suspending agent, aqueous emulsion, wettable powder, water dispersible granules.Adjuvant used, carrier and processing technology use known component.
In above-mentioned various dosage forms, the gross mass percentage composition of active ingredient fluxapyroxad and Zhongshengmycin is 0.5%~85%, example
Such as, when the mass percentage of fluxapyroxad and Zhongshengmycin is respectively 30% and 3%, gross mass percentage composition is
33%.
First, preparation processing formulation Example
Embodiment 1：42% fluxapyroxad Zhongshengmycin suspending agent (fluxapyroxad：Zhongshengmycin=20：1)
It is made according to common process, wherein fluxapyroxad 40g, Zhongshengmycin 2g, sodium lignin sulfonate (dispersant) 4g,
Lauryl sodium sulfate (wetting agent) 2g, ethylene glycol (antifreeze) 4g, bentonite (thickener) 3g, organic silicone (antifoaming agent)
3g, deionized water are mended to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 5%~80%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 2：30% fluxapyroxad Zhongshengmycin water dispersible granules (fluxapyroxad：Zhongshengmycin=5：1)
It is made according to common process, wherein fluxapyroxad 25g, Zhongshengmycin 5g, Negel (dispersant) 5g,
Sodium lignin sulfonate (dispersant) 7g, lauryl sodium sulfate (wetting agent) 2g, ammonium sulfate (disintegrant) 5g, precipitated calcium carbonate
(filler) complements to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 5%~85%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 3：84% fluxapyroxad Zhongshengmycin wettable powder (fluxapyroxad：Zhongshengmycin=20：1)
It is made according to common process, wherein fluxapyroxad 80g, Zhongshengmycin 4g, lauryl sodium sulfate (wetting agent)
2g, sodium lignin sulfonate (dispersant) 3g, NNO (dispersant) 5g, kaolin complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 5%~85%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 4：6% fluxapyroxad Zhongshengmycin microemulsion (fluxapyroxad：Zhongshengmycin=1：5)
It is made according to common process, wherein fluxapyroxad 1g, Zhongshengmycin 5g, N-Methyl pyrrolidone (solvent) 10g,
Isopropanol (solvent) 5g, No. 500 (emulsifier) 5g of agriculture breast, No. 1601 (emulsifier) 5g of agriculture breast, deionized water complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 0.5%~50%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 5：10% fluxapyroxad Zhongshengmycin microcapsule suspending agent (fluxapyroxad：Zhongshengmycin=1：1)
It is made according to common process, wherein fluxapyroxad 5g, Zhongshengmycin 5g, cyclohexanone (solvent) 1g, polyisocyanic acid
Ester (curing agent) 0.4g, ethylene glycol (antifreezing agent) 0.4g, Arabic gum (thickener) 1g, deionized water complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 5%~60%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 6：10% fluxapyroxad Zhongshengmycin aqueous emulsion (fluxapyroxad：Zhongshengmycin=1：1)
It is made according to common process, wherein fluxapyroxad 5g, Zhongshengmycin 5g, calcium dodecyl benzene sulfonate (emulsifier)
2.1g, phenethyl phenol polyethenoxy ether (emulsifier) 1.5g, cyclohexanone (solvent) 10.1g, toluene (solvent) 10.2g, xanthans
(thickener) 0.5g, deionized water complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 1%~60%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 7：0.55% fluxapyroxad Zhongshengmycin granule (fluxapyroxad：Zhongshengmycin=10：1)
It is made according to common process, wherein fluxapyroxad 0.5g, Zhongshengmycin 0.05g, cornstarch (dispersing aid)
0.5g, polyethylene glycol (binding agent) 0.1g, polyvinyl alcohol (sustained release agent) 0.1g, kaolin (filler) complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 0.5%~85%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 8：5.5% fluxapyroxad Zhongshengmycin microcapsule suspending agent (fluxapyroxad：Zhongshengmycin=1：
10)
It is made according to common process, wherein fluxapyroxad 0.5g, Zhongshengmycin 5g, cyclohexanone (solvent) 1g, polyisocyanate cyanogen
Acid esters (curing agent) 0.4g, ethylene glycol (antifreezing agent) 0.4g, Arabic gum (thickener) 1g, deionized water complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 0.5%~60%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
Embodiment 9：2.1% fluxapyroxad Zhongshengmycin granule (fluxapyroxad：Zhongshengmycin=1：20)
It is made according to common process, wherein fluxapyroxad 0.1g, Zhongshengmycin 2g, cornstarch (dispersing aid)
0.5g, polyethylene glycol (binding agent) 0.1g, polyvinyl alcohol (sustained release agent) 0.1g, kaolin (filler) complement to 100g.
The weight ratio of fluxapyroxad and Zhongshengmycin can be 20 in the present embodiment：1~1：Change between 20, the two
Mass percentage can change between 0.5~85%, be also adjusted accordingly, formed new therewith using the proportioning of auxiliary agent
Embodiment.
2nd, biological activity determination and field control effectiveness test example
Pesticide is made in the combination of active principles of different pesticides, be current exploitation and develops novel pesticide and prevention agriculturally
A kind of effective and quick way of resistance pest and disease damage.After the pestsides synthesis of different cultivars, three kinds of type of action are typically exhibited：
Summation action, synergistic effect and antagonism.But it is specially which kind of effect, it is unpredictable, it only could really by a large number of experiments
It is fixed.
Inventor has found that fluxapyroxad is combined to multiple diseases with Zhongshengmycin with bright by a large amount of screening test
Aobvious synergistic function.Present example provides above-mentioned bactericidal composition in prevention fresh kidney beans damping-off, pepper ralstonia solanacearum as a result,
Application, effect is not only the simple addition of two kinds of medicaments, is specifically illustrated with following bioassay example.
One) biological activity determination example
Fluxapyroxad compounds with Zhongshengmycin and the joint toxicity measuring of fresh kidney beans rhizoctonia solani is tested
For trying object：Fresh kidney beans rhizoctonia solani (Rhizoctonia solani).
Experiment is using mycelial growth rate method：To contain the aqua sterilisa of suitable dimethylbenzene and Tween-80 as control
(CK).4mL liquids is taken to be added in the conical flask equipped with the hot culture mediums of 36mL (PDA culture medium, 45-50 DEG C), after shaking up, rapidly
Diameter 90mm glass culture dish is poured into, each culture dish pours into band medicine culture medium 10mL, each 4 repetitions of processing, horizontal rest,
After cooling tablet.Bacteria cake is cut for examination colony edge from culture 3d with diameter 5mm card punch, mycelia will be carried with needle is chosen
Be connected on one side on the malicious culture medium of band, all operations carry out sterile working in superclean bench.24 ± 1 DEG C are placed on after processing
Camera bellows culture in constant temperature sterile culture case measures the colony diameter of each processing after 3d respectively using crossing method, calculates bacterium colony
Average value, the mycelial growth inhibition rate of diameter.
Mode of application judgement is using co-toxicity coefficient (CTC) method.The calculation formula of co-toxicity coefficient is as follows：
Survey toxicity index (ATI)=(standard agent LC50/ reagent agent LC50)×100
In theoretical toxicity index (TTI)=A medicaments ATI × mixture in percentage composition+B medicaments ATI × mixture of A B hundred
Divide content
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
When CTC≤80, then composition shows as antagonism, and as 80 ＜ CTC ＜ 120, then composition shows as being added and make
With when CTC >=120, then composition shows as synergistic effect.
Result of the test：Fluxapyroxad is shown in the joint toxicity measuring result of fresh kidney beans rhizoctonia solani after being compounded with Zhongshengmycin
Table 1.
1 fluxapyroxad of table and Zhongshengmycin compound the joint toxicity measuring result of the test to fresh kidney beans rhizoctonia solani
| Processing | EC50(μg/mL) | ATI | TTI | Co-toxicity coefficient CTC |
| Fluxapyroxad | 0.087 | 100.0 | / | / |
| Zhongshengmycin | 20.370 | 0.4 | / | / |
| Fluxapyroxad 80:Zhongshengmycin 1 | 0.072 | 120.8 | 98.8 | 122.34 |
| Fluxapyroxad 40:Zhongshengmycin 1 | 0.057 | 152.6 | 97.6 | 156.43 |
| Fluxapyroxad 20:Zhongshengmycin 1 | 0.042 | 206.7 | 95.3 | 216.94 |
| Fluxapyroxad 10:Zhongshengmycin 1 | 0.048 | 181.3 | 90.9 | 199.29 |
| Fluxapyroxad 5:Zhongshengmycin 1 | 0.054 | 161.1 | 83.4 | 193.17 |
| Fluxapyroxad 1:Zhongshengmycin 1 | 0.087 | 100.0 | 50.2 | 199.15 |
| Fluxapyroxad 1:Zhongshengmycin 5 | 0.271 | 32.1 | 17.0 | 188.59 |
| Fluxapyroxad 1:Zhongshengmycin 10 | 0.482 | 18.0 | 9.5 | 190.42 |
| Fluxapyroxad 1:Zhongshengmycin 20 | 0.867 | 10.0 | 5.2 | 194.14 |
| Fluxapyroxad 1:Zhongshengmycin 40 | 2.485 | 3.5 | 2.9 | 122.60 |
| Fluxapyroxad 1:Zhongshengmycin 80 | 3.689 | 2.4 | 1.7 | 142.38 |
1 co-toxicity of table test the result shows that, fluxapyroxad and Zhongshengmycin compounding 80：1~1：80 proportioning
In the range of 120 are all higher than to the co-toxicity coefficient CTC of fresh kidney beans rhizoctonia solani joint toxicity measuring, have synergistic effect.Especially exist
20：1~1：In 20 ratio range, CTC is all higher than 180, and synergistic effect is notable.
Two) field control effectiveness test example
1st, to the field control effectiveness test of fresh kidney beans damping-off
It tests and is carried out in November, 2014 in one vegetable field of Hainan Province Sanya precipice cities and towns, which plants fresh kidney beans, beans year after year
The method serious, this experiment uses spray (granule is spread fertilizer over the fields) occurs for angle damping-off, and the fresh kidney beans growth of selection is basically identical
(7d after plantation), and 10d investigates damping-off incidence (not falling ill before medicine, do not investigate state of an illness radix) after medicine, per cell pair
5 points of samplings of linea angulata, every is investigated 5 plants, and record investigation total strain number, diseased plant number calculates preventive effect, and calculation formula is as follows：
Data can obtain from table 2, and various dosage form synergistic effects are apparent after fluxapyroxad is compounded with Zhongshengmycin；It applies
10d after medicine, each compound drug is to the control effect of fresh kidney beans damping-off also significantly better than control single dose.
2 fluxapyroxad of table compounds the field control effect to fresh kidney beans damping-off with Zhongshengmycin
2nd, to the field control effectiveness test of pepper ralstonia solanacearum
It tests and is carried out in December, 2014 in one green house of vegetables of Shouguang City of Shandong Province, with the side of pouring root (granule is spread fertilizer over the fields)
Method, the chili growth of selection is basically identical, is in vegetative growth phase, and the generation of former years bacterial wilt is heavier, and 60d investigation is peppery after medicine
Green pepper bacterial wilt incidence (is not fallen ill, do not investigate state of an illness radix) before medicine, and per the 5 points of samplings of cell diagonal, every is investigated 5 plants,
Record investigation total strain number, diseased plant number calculate preventive effect, and calculation formula is as follows：
Data can obtain from table 3, and various dosage form synergistic effects are apparent after fluxapyroxad is compounded with Zhongshengmycin；It applies
60d after medicine, each compound drug are also significantly better than single dose to the control effect of pepper ralstonia solanacearum.
3 fluxapyroxad of table compounds the field control effect to pepper ralstonia solanacearum with Zhongshengmycin
From fluxapyroxad and Zhongshengmycin compounding to fresh kidney beans damping-off, the field control effectiveness test result of pepper ralstonia solanacearum
It sees, each compound drug has damping-off and bacterial wilt good control effect, and preventive effect is significantly better than control single dose.Illustrate to compound
With synergistic effect, the lasting period extends, can reduce dosage and spraying times, drug resistance is delayed to generate, while can reduce anti-
Control cost.
The foregoing is merely a prefered embodiment of the invention, is not intended to limit the invention, it is all the present invention spirit and
All any modification, equivalent and improvement made within principle etc., should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of bactericidal composition, it is characterised in that：Contain active ingredient fluxapyroxad and Zhongshengmycin, the two in composition
Mass ratio be 80：1~1：80.
2. bactericidal composition according to claim 1, it is characterised in that：Active ingredient fluxapyroxad and Zhongshengmycin
Mass ratio is 20：1~1：20.
3. bactericidal composition according to claim 1 or 2, it is characterised in that：The dosage form that composition can be made has particle
Agent, microcapsule suspending agent, microemulsion, aqueous emulsion, suspending agent, wettable powder, water dispersible granules.
4. bactericidal composition according to claim 3, it is characterised in that：The gross mass percentage of active ingredient contains in composition
Measure is 0.5%~85%.
5. bactericidal composition according to claim 1 is used to prevent vegetables, fruit tree, the gray mold on flowers, powdery mildew, charcoal
Subcutaneous ulcer disease, rust, banded sclerotial blight, early blight, leaf mold, leaf spot, scab, droop, soft rot, bacterial angular leaf spot, blueness are withered
Disease, root rot, damping-off, tar spot, the purposes of shot hole.
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