CN101697722A - Famoxadone-containing bactericidal composition - Google Patents
Famoxadone-containing bactericidal composition Download PDFInfo
- Publication number
- CN101697722A CN101697722A CN200910209736A CN200910209736A CN101697722A CN 101697722 A CN101697722 A CN 101697722A CN 200910209736 A CN200910209736 A CN 200910209736A CN 200910209736 A CN200910209736 A CN 200910209736A CN 101697722 A CN101697722 A CN 101697722A
- Authority
- CN
- China
- Prior art keywords
- composition
- bacterium ketone
- oxazole bacterium
- bactericidal composition
- dimethirimol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
The invention relates to a bactericidal composition. Effective components of the bactericidal composition are famoxadone (A) and a pyrimidine-type bactericide (B), wherein the pyrimidine-type bactericide is ethirimol, ethirimol sulfonic ester or dimethirimol; the mass ratio of A to B is between 80:1 and 1:80; and the weight percentage content of active components in the composition is 5 to 80 percent. The composition can be prepared into cream, suspending agents, wettable powder, water dispersible granules, micro-emulsions and other forms of agents. The bactericidal composition is applied in farmland, orchards and other places, and is used to prevent and control various plant diseases, particularly powdery mildew on grain, vegetables, fruit trees and other crops.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially the bactericidal composition of Han famoxadone and a kind of miazines bactericide belongs to the disinfectant use in agriculture field.
Background technology
Oxazole bacterium ketone (famoxadone) is a kind of wide-spectrum bactericide, is mainly used in important disease that control causes by sac fungi, basidiomycetes, oomycetes such as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight etc.
Oxazole bacterium ketone is the mitochondrial respiratory inhibitor, and the site is very single but it suppresses mitochondrial electronics transfer function, and germ produces the adaptive variation to medicament easily, the preventive effect of medicament is reduced even invalid.Existing abroad at present drug-fast relevant report uses single agent to have bigger risk for a long time.
With different pesticide active ingredient applied in any combination, there is the composition of synergistic effect not only can obviously improve actual preventive effect, reduce dosage and cost, also helping to avoid the generation and the suspension of pesticide resistance generation speed of germ resistance, is a kind of effective means that solves at present that cost is higher in the agricultural chemicals list agent application process, fungicidal spectrum is narrow and easily produce problems such as resistance.
In view of this, the sterilization synergistic composition of exploitation Han famoxadone has suitable necessity and huge actual application value.
Summary of the invention
The object of the present invention is to provide that a kind of new resistance risk is little, cost is low, good drug efficacy, long bactericidal composition of lasting period.
The inventor after an existing oxazole bacterium ketone and miazines bactericide are mixed in certain proportion unexpectedly, has significant synergistic effect to diseases such as powdery mildew, rust, glume blight by a large amount of indoor biometrics and field control effectiveness tests.
Described miazines bactericide comprises the phonetic phenol of second, bupirimate, dimethirimol etc.Its mechanism of action belongs to adenosine deaminase inhibitors.The miazines bactericide is a systemic fungicide, has protection and therapeutic action, can be absorbed rapidly by plant roots, stem, leaf, and run to each position in plant corpus.Be mainly used in the powdery mildew of control crop.
The phonetic phenol English name of second: ethirimol
Chemical name: 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine
Molecular formula: C
11H
19N
3O
Be mainly used in control cereal crop powdery mildew, also can prevent and treat the ground family crop powdery mildew.
Bupirimate English name: bupirimate
Chemical name: 5-butyl-2-ethylamino-6-methylpyrimidine-4-base dimethylamino sulphonic acid ester
Molecular formula: C
13H
24N
4O
3S
Prevent and treat various powdery mildews, as apple, grape, cucumber, strawberry, rose, beet powdery mildew.
Dimethirimol: English name: dimethirimol
Chemical name: 5-normal-butyl-2-dimethylamino-6-methylpyrimidine 4-alcohol
Molecular formula: C
11H
19N
3O
Be mainly used in the powdery mildew of control tobacco, tomato, ornamental plants
Above-mentioned miazines bactericide all is bactericide well known in the art, can obtain by various commercial channel.
On the basis of above-mentioned discovery, through composition is carried out symphyogenetic quantitative analysis, formed technical scheme of the present invention, that is: a kind of bactericidal composition, the mass ratio of Zu compound Zhong oxazole bacterium ketone (A) and miazines bactericide (B) is 80: 1～1: 80, and A is 20: 1～1: 20 with B quality optimization ratio.Active component gross mass percentage composition is 5～80% in the composition.
The present composition can be prepared into known method and be fit to any one formulation that agricultural is used, and formulation has missible oil, suspending agent, aqueous emulsion, wetting powder, water dispersible granules, microemulsion etc. preferably.These preparations can be prepared by method in common, for example, active substance is mixed with liquid flux and/or solid carrier, add surfactant such as emulsifier, dispersant, stabilizing agent, wetting agent simultaneously, can also add adhesive, defoamer, oxidant, dyestuff etc.
For water dispersible granules, one or more in spendable dispersant such as polycarboxylate, lignosulfonates, NNO4, the alkylnaphthalene sulfonate; In wetting agent such as polyoxyethylene nonylphenol ether, polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In disintegrant such as ammonium sulfate, urea, sucrose, the glucose one or more; In binding agent such as diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose one or more; In filler such as diatomite, calcium bicarbonate, kaolin, white carbon, talcum powder, the potter's clay one or more.
For suspending agent, one or more in spendable dispersant such as polycarboxylate, lignosulfonates such as sodium lignin sulfonate, the alkylnaphthalene sulfonate; Among emulsifier such as Nongru-700 # (common name alkyl phenol formaldehyde resin polyoxyethylene ether), nekal formaldehyde condensation products, agricultural newborn 2201#, this dish-60# (common name sorbitol anhydride monostearate), agricultural newborn 1601# (common name triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), the TERSPERSE 4894 (2500) one or more; In wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products phosphate, the withered powder of the bitter edible plant, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In thickener such as xanthans, polyvinyl alcohol, the bentonite one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Defoamer such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more.
For wetting powder, in spendable dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, the potter's clay one or more.
For missible oil, one or more in spendable solvent such as ethylene glycol, methyl alcohol, dimethylbenzene, acetone, chloroform, ethyl acetate, ether, N-Methyl pyrrolidone, the methyl iso-butyl ketone (MIBK); The newborn 500# of spendable emulsifier such as farming, agricultural newborn 600#, Nongru-700 #, agricultural newborn 2201#, agricultural newborn 1601#, polyoxyethylene fatty acid ester, polyoxyethylene groups ether, polyoxyethylene fatty acid ammonia, in one or more; In available stabilizing agent such as triphenyl phosphite, the epoxychloropropane one or more.
For aqueous emulsion, in spendable emulsifier such as polyoxyethylene nonylphenol ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl glycol ether sodium sulfonate, triphen ethyl-phenol polyoxyethylene ether phosphate, agricultural newborn 2201#, Nongru-700 # (common name alkyl phenol formaldehyde resin polyoxyethylene ether), agricultural newborn 1601# (common name triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), agricultural newborn 600#, agricultural newborn 400#, the sorbitan fatty acid polyoxyethylene groups ether one or more; In solvent such as dimethylbenzene, carrene, toluene, N-Methyl pyrrolidone, cyclohexanone, acetone, the castor oil one or more, one or more in stabilizing agent such as sodium hydrogen phosphate, this fat of tricresyl phosphite, epoxychloropropane, the aceticanhydride; In antifreezing agent such as methyl alcohol, ethylene glycol, propane diols, the glycerine one or more; In thickener such as xanthans, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more.
For microemulsion, one or more among the newborn 500# of spendable emulsifier such as farming (lauryl sodium sulfate), Nongru-700 # (alkyl phenol formaldehyde resin polyoxyethylene ether), phenethyl phenol polyethenoxy base ether, phenethyl phenol polyethenoxy polyethenoxy ether, agricultural newborn 2201#, agricultural newborn 1601# (triphen ethyl-phenol polyoxyethylene poly-oxygen propylene aether), the agricultural newborn 600#; In solvent such as dimethylbenzene, DMF, toluene, cyclohexanone, the solvent naphtha one or more; In stabilizing agent such as triphenyl phosphite, epoxychloropropane, the aceticanhydride one or more.
The present composition can be the finished product preparation form to be provided, and promptly each material mixes in the composition; The composition of composition also can provide with single agent formulation, directly mixes in bucket (jar) before using.Concentrate of the present invention mixes the concentration that obtains required active substance usually with water.
Composition of the present invention can be used for preventing and treating the important disease that is caused by sac fungi, basidiomycetes etc., is particularly suitable for preventing and treating powdery mildew and rust.It is farmland, orchard etc. that composition of the present invention is used the place.
Composition of the present invention also can with other compound with weeding, desinsection or bactericidal property particularly protective fungicide mix use, also can mix use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner.
The present invention comprises that also a kind of scene kills the method for fungi, before or after crop and/or fruit are susceptible, uses composition of the present invention to the place of crop and/or fruit and growth or storage.Can use by common method, as cast, injection, spraying, dusting, distribution.Amount of application of the present invention is with weather condition or crop state variation.The duration of protective effect is usually relevant with the content of individualized compound in the composition, and is relevant with extraneous factor, weather for example, but by using suitable formulation can slow down climatic influences.
Composition of the present invention possesses following advantage: the one, and the composition synergistic effect is obvious, and drug effect significantly improves; The 2nd, the composition drug effect improves, and the field consumption descends, and has reduced production and use cost, reduces residue of pesticide and environmental pollution; The 3rd, composition is made up of the active ingredient of different mechanism of action, and action site increases, and helps overcoming and delays the drug-fast generation of germ.The 4th, enlarged fungicidal spectrum, can prevent and treat by microbial diseases of other cause of diseases such as oomycetes.
Embodiment
Below further specify the present invention with specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of being made within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Percentage composition is mass percent in all preparation proportionings.
The missible oil example
Press formula rate, add solvent, former medicine, emulsifier respectively, mix, use the hot bath heating for dissolving in case of necessity, promptly obtain transparence missible oil.
The phonetic phenol missible oil of embodiment 1:40.5% oxazole bacterium ketone second
Oxazole bacterium ketone 40%, the phonetic phenol 0.5% of second, methyl alcohol 10% (cosolvent), agricultural newborn 600#5% (emulsifier), farming breast 500
#5% (emulsifier), dimethylbenzene (solvent) complements to 100%.
Embodiment 2:40.5% oxazole bacterium ketone bupirimate missible oil
Oxazole bacterium ketone 0.5%, bupirimate 40%, methyl iso-butyl ketone (MIBK) (cosolvent) 9%, agricultural newborn 600# (emulsifier) 6%, farming breast 500
#(emulsifier) 4%, dimethylbenzene (solvent) complements to 100%.
The wetting powder example
Press formula rate, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultrafine crusher is pulverized, promptly obtain converted products.
The phonetic phenol wetting powder of embodiment 3:80% oxazole bacterium ketone second
Oxazole bacterium ketone 65%, the phonetic phenol 15% of second, lauryl sodium sulfate 2% (wetting agent), sodium lignin sulfonate 3% (dispersant), white carbon black 10% (filler), kaolin complements to 100%.
Embodiment 4:50% oxazole bacterium ketone dimethirimol wetting powder
Oxazole bacterium ketone 20%, dimethirimol 30%, lauryl sodium sulfate (wetting agent) 3%, sodium lignin sulfonate (dispersant) 3%, white carbon black (filler) 11%, bentonite complements to 100%.
The aqueous emulsion example
Press formula rate, former medicine, solvent, emulsifier are added with cosolvent be in the same place, make and be dissolved into even oil phase.Water, antifreeze etc. is mixed, become even water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the aqueous emulsion of favorable dispersibility.
Embodiment 5:5% oxazole bacterium ketone ethirimol emulsion in water
Oxazole bacterium ketone 2.5%, the phonetic phenol 2.5% of second, dimethylbenzene (solvent) 10%, glycerine (cosolvent) 5%, calcium dodecyl benzene sulfonate (dispersant) 1%, polyoxyethylene aliphatic alcohol ether (emulsifier) 5%, water complements to 100%.
Embodiment 6:15% oxazole bacterium ketone bupirimate aqueous emulsion
Oxazole bacterium ketone 5%, bupirimate 10%, dimethylbenzene (solvent) 10%, glycerine (cosolvent) 5%, calcium dodecyl benzene sulfonate (dispersant) 2%, polyoxyethylene aliphatic alcohol ether (emulsifier) 5%, water complements to 100%.
The water dispersible granules example
Press formula rate, former medicine and powder carrier, moistening spreader-sticker and binding agent etc. are mixed pulverizing, after adding water again and mediating, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.And then drying, screening (pressing the screen cloth scope) promptly get granular product.
Embodiment 7:35% oxazole bacterium ketone dimethirimol water dispersible granules
Oxazole bacterium ketone 30%, dimethirimol 5%, Negel (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (wetting agent) 2%, ammonium sulfate (disintegrant) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 8:70% oxazole bacterium ketone ethirimol water dispersible granules
Oxazole bacterium ketone 50%, the phonetic phenol 20% of second, Negel (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (wetting agent) 2%, ammonium sulfate (disintegrant) 5%, precipitated calcium carbonate complements to 100%.
The suspending agent example
Press formula rate, the ratio of each component such as active component, dispersant, wetting agent and water in prescription mixed, after grinding or high speed shear, make suspending agent.
The phonetic phenol suspending agent of embodiment 9:20% oxazole bacterium ketone second
Oxazole bacterium ketone 10%, the phonetic phenol 10% of second, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, lauryl sodium sulfate (wetting agent) 3%, xanthans (thickener) 2%, bentonite (thickener) 1%, glycerine (antifreeze) 5%, water complements to 100%.
Embodiment 10:30% oxazole bacterium ketone dimethirimol suspending agent
Oxazole bacterium ketone 20%, dimethirimol 10%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, lauryl sodium sulfate (wetting agent) 3%, xanthans (thickener) 2%, bentonite (thickener) 1%, glycerine (antifreeze) 5%, water complements to 100%.
The microemulsion example
Press formula rate, active substance is dissolved in solvent and the cosolvent, add surfactant, mix and make oil phase; With water-soluble component and water mixed water, again oil phase is added aqueous phase or water is added in the oil phase, the limit edged stirs, and makes microemulsion.
Embodiment 11:11% oxazole bacterium ketone bupirimate microemulsion
Oxazole bacterium ketone 1%, bupirimate 10%, acetone (solvent) 10%, dimethylbenzene (solvent) 10%, farming breast 600
#(emulsifier) 5%, farming breast 601
#(emulsifier) 5%, water complements to 100%.
The phonetic phenol microemulsion of embodiment 12:21% oxazole bacterium ketone second
Oxazole bacterium ketone 20%, the phonetic phenol 1% of second, sorbierite (solvent) 10%, dimethylbenzene (solvent) 10%, farming breast 600
#(emulsifier) 5%, farming breast 601
#(emulsifier) 5%, water complements to 100%.
Embodiment 13:30% oxazole bacterium ketone dimethirimol microemulsion
Oxazole bacterium ketone 5%, dimethirimol 25%, sorbierite (solvent) 8%, dimethylbenzene (solvent) 12%, farming breast 600
#(emulsifier) 6%, farming breast 601
#(emulsifier) 7%, water complements to 100%.
Embodiment 14:25% oxazole bacterium ketone bupirimate microemulsion
Oxazole bacterium ketone 20%, bupirimate 5%, sorbierite (solvent) 8%, dimethylbenzene (solvent) 12%, farming breast 600
#(emulsifier) 6%, farming breast 601
#(emulsifier) 7%, water complements to 100%.
Different pesticide active ingredients shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.But be specially which kind of effect, unpredictable, have only by a large amount of tests and just can know.Compound synergic is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation speed of germ widely, and be the important means of scientific prevention and cure disease.
The inventor is by a large amount of screening tests; an existing oxazole bacterium ketone and above-mentioned any one pyrimidines combination all have remarkable role in synergy to white powder germ, rest fungus etc., and are not only the simple addition (seeing biologicall test example 1,2 for details) of two kinds of medicaments.
Biologicall test embodiment 1: oxazole bacterium ketone and bupirimate, the composite Toxicity Determination of dimethirimol to the powdery mildew of cucumber bacterium
Subjects: powdery mildew of cucumber bacterium (picking up from the field)
Test method: with reference to " the agricultural industry criteria NY/T1156.4-2006 of the People's Republic of China (PRC) ".Choose potted plant two leaf period cucumber seedlings of growth potential unanimity, 5 basins are selected in each processing for use, number standby.Under 50PSI pressure, spray every basin 5mL with the Potter spray tower.Test medicine is referring to table 1, table 2, table 3, and each medicament is provided with 5 concentration gradients.Carrying out inoculum density behind the 24h is 3 * 10
5The powdery mildew of cucumber bacterium conidial suspension of individual spore/mL.With the cucumber seedling that sprays the equivalent clear water is blank.After the inoculation cucumber seedling being put into the greenhouse cultivates.Behind the 7d,, and calculate control efficiency according to the morbidity grade scale complete stool investigation disease index of powdery mildew of cucumber.
Powdery mildew of cucumber state of an illness grade scale:
0 grade: blade does not have scab;
1 grade: lesion area accounts for the area of whole blade below 5%;
3 grades: lesion area account for whole blade area 6%～10%;
5 grades: lesion area accounts for 11%～25% of whole blade area;
7 grades: lesion area accounts for 25%～50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
Calculate concentration EC in the inhibition with method of least squares
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100.
CTC≤80 are antagonism, and 80＜CTC＜120 are summation action, and CTC 〉=120 are synergistic effect.
When the proportioning of ， oxazole bacterium ketone and bupirimate is between 80: 1～1: 80 as can be known from Table 1, the powdery mildew of cucumber bacterium is had synergistic effect, in the time of especially between 20: 1～1: 20, co-toxicity coefficient is more than 190.
The composite results from pot experiment test of table 1 oxazole bacterium ketone and bupirimate to the powdery mildew of cucumber bacterium
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Oxazole bacterium ketone | ??11.35 | ??100 | ??/ | ??/ |
| Bupirimate | ??23.41 | ??48.48 | ??/ | ??/ |
| Oxazole bacterium ketone 80+ bupirimate 1 | ??8.95 | ??126.82 | ??99.36 | ??127.63 |
| Oxazole bacterium ketone 50+ bupirimate 1 | ??9.31 | ??121.91 | ??98.98 | ??123.16 |
| Oxazole bacterium ketone 20+ bupirimate 1 | ??5.87 | ??193.36 | ??97.55 | ??198.22 |
| Oxazole bacterium ketone 10+ bupirimate 1 | ??6.12 | ??185.46 | ??95.32 | ??194.57 |
| Oxazole bacterium ketone 1+ bupirimate 1 | ??7.03 | ??161.45 | ??74.24 | ??217.47 |
| Oxazole bacterium ketone 1+ bupirimate 10 | ??9.25 | ??122.70 | ??53.17 | ??230.78 |
| Oxazole bacterium ketone 1+ bupirimate 20 | ??9.49 | ??119.59 | ??50.94 | ??234.80 |
| Oxazole bacterium ketone 1+ bupirimate 50 | ??13.58 | ??83.58 | ??49.49 | ??168.87 |
| Oxazole bacterium ketone 1+ bupirimate 80 | ??15.69 | ??72.34 | ??49.12 | ??147.27 |
， oxazole bacterium ketone and dimethirimol are composite as can be known from Table 2, are between 80: 1～1: 80 the time in proportioning, and co-toxicity coefficient has synergistic effect all more than 120 to the powdery mildew of cucumber bacterium, and in the time of especially between 20: 1～1: 20, co-toxicity coefficient is more than 180.
The composite results from pot experiment test of table 2 oxazole bacterium ketone and dimethirimol to the powdery mildew of cucumber bacterium
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Oxazole bacterium ketone | ??10.57 | ??100 | ??/ | ??/ |
| Dimethirimol | ??14.29 | ??73.97 | ??/ | ??/ |
| Oxazole bacterium ketone 80+ dimethirimol 1 | ??8.07 | ??130.98 | ??99.68 | ??131.40 |
| Oxazole bacterium ketone 50+ dimethirimol 1 | ??8.59 | ??123.05 | ??99.49 | ??123.68 |
| Oxazole bacterium ketone 20+ dimethirimol 1 | ??5.48 | ??192.88 | ??98.76 | ??195.30 |
| Oxazole bacterium ketone 10+ dimethirimol 1 | ??5.79 | ??182.56 | ??97.63 | ??186.98 |
| Oxazole bacterium ketone 1+ dimethirimol 1 | ??6.56 | ??161.13 | ??86.98 | ??185.28 |
| Oxazole bacterium ketone 1+ dimethirimol 10 | ??7.05 | ??149.93 | ??76.33 | ??196.41 |
| Oxazole bacterium ketone 1+ dimethirimol 20 | ??7.67 | ??137.81 | ??75.21 | ??183.24 |
| Oxazole bacterium ketone 1+ dimethirimol 50 | ??8.95 | ??118.10 | ??74.48 | ??158.57 |
| Oxazole bacterium ketone 1+ dimethirimol 80 | ??11.32 | ??93.37 | ??74.29 | ??125.69 |
The proportioning that measurement result (table 3) shows ， oxazole bacterium ketone and the phonetic phenol of second has synergistic effect to the powdery mildew of cucumber bacterium between 80: 1～1: 80 the time, and in the time of especially between 20: 1～1: 20, co-toxicity coefficient is more than 180.
The composite Toxicity Determination result of table 3 oxazole bacterium ketone and the phonetic phenol of second to the powdery mildew of cucumber bacterium
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Oxazole bacterium ketone | ??12.31 | ??100 | ??/ | ??/ |
| The phonetic phenol of second | ??19.17 | ??64.21 | ??/ | ??/ |
| The phonetic phenol 1 of oxazole bacterium ketone 80+ second | ??8.95 | ??137.54 | ??99.56 | ??138.15 |
| The phonetic phenol 1 of oxazole bacterium ketone 50+ second | ??9.26 | ??132.94 | ??99.29 | ??133.87 |
| The phonetic phenol 1 of oxazole bacterium ketone 20+ second | ??6.47 | ??190.26 | ??98.29 | ??193.56 |
| The phonetic phenol 1 of oxazole bacterium ketone 10+ second | ??6.85 | ??179.71 | ??96.75 | ??185.75 |
| Handle | ??EC 50(μg/mL) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| The phonetic phenol 1 of oxazole bacterium ketone 1+ second | ??7.32 | ??168.17 | ??82.11 | ??204.82 |
| The phonetic phenol of oxazole bacterium ketone 1 second+10 | ??8.19 | ??150.31 | ??67.47 | ??222.78 |
| The phonetic phenol 20 of oxazole bacterium ketone 1+ second | ??9.78 | ??125.87 | ??65.92 | ??190.95 |
| The phonetic phenol 50 of oxazole bacterium ketone 1+ second | ??12.65 | ??97.31 | ??64.92 | ??149.90 |
| The phonetic phenol 80 of oxazole bacterium ketone 1+ second | ??14.37 | ??85.66 | ??64.66 | ??132.49 |
Field application examples 1: oxazole bacterium ketone and the composite field control effectiveness test of pyrimidines to powdery mildew of cucumber
Choose the powdery mildew of cucumber heavier plot of morbidity throughout the year, adopt spray-on process to put in order the strain spraying.Test medicine is pressed the dosage thin up of table 4, even spraying, and till being sprayed onto blade and dripping, 20 square metres of each sub-district areas are repeated in 4 sub-districts of every processing.Be treated to blank with clear water.Behind disease initial stage of origination investigation disease index, carry out dispenser first time, execute second, third time medicine after 7 days, 14 days, and behind first, second time medicine 7 days, the incidence of 10 days investigation powderys mildew of cucumber behind the medicine for the third time, calculating disease index and preventive effect.5 samplings are adopted in every sub-district, and all blades are investigated in every some investigation two strains, and the percentage that accounts for whole leaf area with lesion area comes the classification record.
Grade scale:
0 grade: no scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
The drug effect computational methods:
The results are shown in Table 4.
The field control effectiveness test result of table 4 composition for preventing and controlling powdery mildew of cucumber
As can be seen from Table 5, composition is not higher than under the situation of single agent at the consumption of active ingredient, and the preventive effect of powdery mildew of cucumber all obviously is better than single agent, shows that there is tangible synergy the two composite back to powdery mildew of cucumber.Composition has reduced the amount of application and the use cost of active ingredient when drug effect improves, reduced residue of pesticide and environmental pollution.
Claims (7)
1. bactericidal composition, it is characterized in that: active ingredient is oxazole bacterium ketone (A) and a kind of miazines bactericide (B).
2. bactericidal composition according to claim 1 is characterized in that: preferred 80: 1～1: 80 of the mass ratio of effective constituents A and B.
3. bactericidal composition according to claim 2 is characterized in that: preferred 20: 1～1: 20 of the mass ratio of effective constituents A and B.
4. according to each described bactericidal composition of claim 1-3, it is characterized in that: described miazines bactericide is selected from the phonetic phenol of second, bupirimate, dimethirimol.
5. according to each described bactericidal composition of claim 1-3, it is characterized in that: active component quality percentage composition is 5～80% in the composition.
6. bactericidal composition according to claim 1 is characterized in that: said composition can be mixed with missible oil, suspending agent, aqueous emulsion, wetting powder, water dispersible granules and microemulsion.
7. the described bactericidal composition of claim 1 is used to prevent and treat the disease on cereal, the fruit and vegetables.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910209736 CN101697722B (en) | 2009-10-29 | 2009-10-29 | Famoxadone-containing bactericidal composition |
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| CN 200910209736 CN101697722B (en) | 2009-10-29 | 2009-10-29 | Famoxadone-containing bactericidal composition |
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| CN101697722A true CN101697722A (en) | 2010-04-28 |
| CN101697722B CN101697722B (en) | 2013-04-17 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101983563A (en) * | 2010-11-28 | 2011-03-09 | 陕西美邦农药有限公司 | Bactericidal composite and applications thereof |
| CN105379731A (en) * | 2015-11-06 | 2016-03-09 | 南京华洲药业有限公司 | Sterilizing composition containing mepanioyrim and famoxadone and application thereof |
| CN105900991A (en) * | 2012-06-18 | 2016-08-31 | 陕西美邦农药有限公司 | Fenamidone containing antibacterial composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0418047D0 (en) * | 2004-08-12 | 2004-09-15 | Syngenta Participations Ag | Fungicidal compositions |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101983563A (en) * | 2010-11-28 | 2011-03-09 | 陕西美邦农药有限公司 | Bactericidal composite and applications thereof |
| CN105900991A (en) * | 2012-06-18 | 2016-08-31 | 陕西美邦农药有限公司 | Fenamidone containing antibacterial composition |
| CN105379731A (en) * | 2015-11-06 | 2016-03-09 | 南京华洲药业有限公司 | Sterilizing composition containing mepanioyrim and famoxadone and application thereof |
| CN105379731B (en) * | 2015-11-06 | 2017-12-05 | 南京华洲药业有限公司 | It is a kind of containing mepanipyrim He the bactericidal composition of famoxadone and its application |
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| CN101697722B (en) | 2013-04-17 |
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